LOC102552566

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC102552566	0.6	0.12	0.0e+00	0.1	0.24	0.24	0.24	8.2e-11	4.4e-26	4.9e-26	5.2e-26
2	Adipose	alternative polyA	XR_001836079.2	0.18	0.09	6.9e-05	-0	0.02	0.02	0.01	7.7e-01	1.2e-03	2.7e-03	4.0e-02
3	Liver	gene expression	LOC102552566	0.17	0.09	4.6e-07	0.04	0.04	0.04	0.04	2.9e-05	1.2e-05	1.6e-05	5.2e-05
4	Brain	gene expression	LOC102552566	0.1	0.13	2.7e-05	0.05	0.04	0.04	0.04	3.6e-05	2.3e-04	2.2e-04	1.8e-04
5	PL	gene expression	LOC102552566	0.16	0.11	8.6e-03	0.02	0.01	0.01	0.01	4.5e-03	1.3e-02	7.3e-03	1.3e-02
6	RMTg	gene expression	LOC102552566	0.22	0.13	1.2e-04	0.1	0.09	0.09	0.08	1.5e-03	2.2e-03	1.7e-03	3.7e-03
7	Adipose	alternative polyA	XR_005494818.1	0.18	0.09	8.7e-05	-0	0.02	0.02	0	5.6e-01	2.2e-03	1.5e-03	7.4e-02
8	Adipose	mRNA stability	LOC102552566	0.22	0.1	9.2e-08	0.04	0.05	0.05	0.04	4.4e-05	2.9e-06	1.6e-06	1.8e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.1	0.1	0.6	-0.2	0.8	-0.3	0.3	0.3	0.4	-0.2	-0.3
Area under the delay curve	1.0	1.1	3.5	-1.5	1.9	-0.8	0.4	0.5	0.4	0.1	-1.2
BMI with tail	3.3	10.6	23.5	-1.2	4.1	-3.0	3.0	2.9	2.8	3.0	-4.9
BMI without tail	2.2	4.6	7.5	-1.6	2.2	-2.2	1.9	1.8	1.8	2.6	-2.7
Body weight	4.0	16.8	21.1	-3.5	4.0	-4.6	4.4	4.2	4.2	3.6	-4.2
Weight adjusted by age	1.1	1.3	2.4	1.5	-0.7	-0.8	1.3	1.2	1.2	1.2	-0.9
Bone surface	0.5	0.9	1.7	-0.5	0.9	-1.0	1.3	1.3	1.3	-0.3	-0.3
Bone volume	0.1	0.2	0.7	0.3	0.4	-0.2	0.5	0.5	0.6	-0.8	0.1
Breakpoint value in progressive ratio session	1.2	1.3	2.3	0.1	-1.4	-1.0	1.5	1.4	1.3	0.9	0.8
Number of licking bursts	0.0	0.0	0.1	-0.2	0.2	-0.1	0.1	0.0	0.0	-0.4	-0.0
Context. condit. distance diff. score	0.1	0.1	0.2	0.5	0.1	0.2	-0.3	-0.3	-0.4	0.1	-0.3
Locomotion velocity, session 1	0.4	0.4	1.7	0.1	0.4	-0.1	0.2	0.2	0.2	1.3	-1.0
Locomotion distance, session 1	1.3	1.6	3.6	-0.6	1.2	-1.1	1.1	1.1	1.0	1.9	-1.8
Locomotion velocity, session 2	2.4	2.8	3.9	-1.0	1.1	-1.9	2.0	2.0	2.0	1.5	-1.7
Locomotion distance, session 2	1.3	1.9	4.6	-1.1	1.1	-1.3	1.0	1.0	1.0	1.8	-2.1
Locomotion velocity, session 3	1.0	1.2	3.7	-0.3	1.9	-0.9	0.7	0.7	0.7	0.2	-1.8
Locomotion distance, session 3	0.2	0.2	0.9	-1.0	0.7	-0.3	0.1	0.1	0.2	-0.3	0.1
Stereotopy head waving bouts, day 3	1.7	2.0	7.0	-1.1	2.7	-0.9	0.4	0.4	0.4	0.9	-2.4
Stereotopy head waving duration, day 3	1.2	1.5	4.4	-1.1	2.0	-0.9	0.4	0.4	0.4	1.0	-2.1
Locomotion velocity, session 7	0.3	0.3	0.9	-0.8	1.0	-0.4	0.1	0.1	0.1	-0.5	-0.5
Locomotion distance, session 7	0.7	0.8	2.4	-1.4	1.5	-0.6	0.1	0.1	0.1	0.4	-1.3
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.5	0.1	-0.2	0.4	0.4	0.4	-0.1	-0.3
Stereotopy head waving duration, day 7	1.1	1.3	2.4	-0.7	0.5	-1.4	1.6	1.6	1.5	0.7	-0.7
Locomotion velocity, session 8	0.5	0.6	2.9	-1.7	0.5	-0.7	0.4	0.4	0.3	0.8	-0.3
Locomotion distance, session 8	0.3	0.4	1.6	-0.0	1.0	-0.2	-0.0	-0.0	-0.1	0.5	-1.3
Degree of sensitization distance	0.9	0.9	4.3	0.2	1.4	-0.4	0.1	0.1	0.1	0.9	-2.1
Degree of sensitization stereotypy	0.4	0.4	0.8	0.9	-0.7	-0.4	0.9	0.9	0.8	-0.1	0.3
Conditioned locomotion	0.9	1.0	1.5	-1.2	0.7	-1.2	1.1	1.0	1.0	0.7	-0.9
Cocaine response after cond. corrected	0.4	0.4	1.8	0.3	0.6	0.3	-0.5	-0.4	-0.4	0.8	-1.4
Cocaine response after cond. not corrected	0.6	0.6	2.2	1.5	-0.2	0.9	-0.8	-0.7	-0.7	0.1	-0.4
Cocaine response before conditioning	2.2	2.6	6.6	2.6	-2.2	1.3	-0.4	-0.3	-0.3	-1.4	2.4
Saline control response	1.6	2.1	3.3	-1.2	0.1	-1.6	1.8	1.7	1.7	1.6	-0.7
Bone: connectivity density	0.9	1.5	1.9	-0.9	1.3	-1.3	1.4	1.4	1.4	0.8	-1.2
Bone: cortical apparent density	0.3	0.4	0.6	0.0	-0.8	-0.5	0.7	0.7	0.7	0.5	0.7
Bone: cortical area	0.2	0.3	0.6	0.0	-0.2	-0.3	0.7	0.7	0.8	-0.1	0.5
Bone: cortical porosity	0.1	0.1	0.3	-0.5	-0.6	-0.2	0.1	0.1	0.0	0.1	0.1
Bone: cortical porosity	0.3	0.3	0.9	-0.9	-0.4	-0.7	0.5	0.5	0.4	0.5	-0.4
Bone: cortical thickness	1.9	3.0	4.8	-1.7	-0.5	-1.9	2.2	2.1	2.2	1.9	-0.2
Bone: cortical thickness	0.4	0.5	0.8	-0.8	-0.5	-0.6	0.7	0.7	0.7	0.9	0.5
Bone: cortical tissue density	0.4	0.5	0.7	-0.1	-0.8	-0.6	0.8	0.8	0.8	0.7	0.6
Condit. Reinf. active minus inactive responses	0.6	0.6	1.7	0.8	-0.3	-0.4	0.8	0.8	0.9	1.3	-0.6
Condit. Reinf. active-inactive response ratio	0.5	0.6	2.4	0.7	-0.9	-0.1	0.5	0.5	0.5	1.5	-0.4
Condit. Reinf. active responses	0.4	0.6	1.7	1.3	-0.1	-0.2	0.7	0.7	0.8	0.8	-0.6
Condit. Reinf. inactive responses	0.4	0.4	2.3	1.5	0.2	0.6	-0.3	-0.3	-0.3	-0.7	0.1
Incentive salience index mean	0.4	0.5	1.0	0.5	0.4	-0.5	0.9	0.9	1.0	0.9	-0.6
Condit. Reinf. lever presses	0.2	0.2	0.7	-0.0	0.8	-0.3	0.5	0.5	0.7	-0.2	-0.0
Condit. Reinf. active minus inactive responses	1.6	2.0	6.4	2.5	-1.6	1.5	-1.0	-0.9	-1.0	-1.1	1.1
Condit. Reinf. active-inactive response ratio	1.7	1.8	7.6	2.8	-0.9	1.2	-0.9	-0.9	-0.9	-1.5	0.4
Condit. Reinf. active responses	0.5	0.7	2.2	1.5	-1.1	0.8	-0.5	-0.4	-0.4	-0.7	0.8
Condit. Reinf. inactive responses	0.1	0.2	0.7	-0.6	-0.3	0.2	-0.2	-0.0	-0.0	0.2	0.8
Condit. Reinf. lever presses	0.4	0.6	2.4	1.6	-0.8	0.1	0.5	0.5	0.5	-0.8	0.4
Condit. Reinf. lever reinforcers received	0.6	0.8	3.0	1.7	-1.4	0.7	-0.2	-0.1	-0.1	-0.6	0.8
Conditioned reinforcement - actives	2.9	2.9	4.9	2.2	-1.6	2.0	-1.8	-1.5	-1.7	-0.9	1.7
Conditioned reinforcement - inactives	1.5	1.7	4.8	2.2	-0.5	1.4	-1.1	-1.2	-1.2	-1.4	0.6
Conditioned locomotion	1.4	1.6	2.6	1.6	0.2	1.4	-1.4	-1.4	-1.6	-1.3	0.2
Patch foraging indifference point 0 sec	0.5	0.9	1.5	-1.2	0.6	-1.1	1.0	1.2	0.9	0.7	-0.4
Patch foraging indifference point AUC	0.7	0.8	1.7	-0.1	-0.5	-0.9	1.2	1.3	1.3	0.6	-0.1
Delay disc. indifference point, 0s delay	1.5	1.7	7.0	-1.1	2.7	-0.7	0.2	0.2	-0.0	0.5	-2.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.3	0.4	-0.1	0.2	0.2	0.2	-0.5	-0.3
Delay disc. indifference point, 2s delay	0.4	0.4	2.3	-0.2	1.5	0.1	-0.3	-0.4	-0.4	-0.7	-0.6
Delay disc. indifference point, 24s delay	0.9	0.9	2.5	-1.6	1.4	-0.9	0.5	0.5	0.5	0.2	-1.1
Delay disc. indifference point, 4s delay	3.8	4.0	10.2	-3.2	3.0	-1.9	1.1	1.0	1.2	0.9	-2.1
Delay disc. indifference point, 8s delay	1.2	1.2	4.7	-2.2	1.8	-0.8	0.0	0.1	0.0	-0.1	-1.1
Indifference point function ln k	1.5	2.1	4.2	0.9	1.0	1.5	-1.9	-2.0	-1.9	-0.9	-0.7
Indifference point function log k	1.5	2.1	4.2	0.9	1.0	1.5	-1.9	-2.0	-1.9	-0.9	-0.7
Patch foraging total patch changes 0 sec	0.7	1.1	2.4	-1.5	0.6	-1.2	1.1	1.2	1.0	0.8	-0.3
Patch foraging total patch changes 12 sec	4.8	6.2	10.5	-2.3	0.2	-3.0	3.1	3.2	3.0	2.2	-1.0
Patch foraging total patch changes 18 sec	0.3	0.4	0.7	-0.8	-0.1	-0.7	0.8	0.9	0.8	0.6	0.0
Patch foraging total patch changes 24 sec	6.1	7.5	11.0	-2.5	1.6	-3.3	3.1	3.3	3.1	2.0	-2.4
Patch foraging total patch changes 6 sec	1.1	1.6	2.9	-1.7	1.0	-1.5	1.4	1.5	1.3	0.8	-0.5
Patch foraging time to switch 0 sec	0.2	0.3	0.5	0.3	0.6	-0.5	0.5	0.7	0.7	-0.5	-0.3
Patch foraging water rate 0 sec	0.5	0.7	1.1	0.5	-0.9	1.0	-0.8	-1.0	-1.0	-0.1	1.0
Patch foraging water rate 12 sec	0.6	1.0	2.3	0.3	0.1	1.1	-1.3	-1.5	-1.5	-0.0	-0.1
Patch foraging water rate 18 sec	0.4	0.5	1.2	-1.0	1.1	0.2	-0.6	-0.7	-0.7	0.5	-0.3
Patch foraging water rate 24 sec	0.6	0.8	1.9	0.2	-0.3	1.1	-1.2	-1.4	-1.2	-0.2	0.7
Patch foraging water rate 6 sec	0.3	0.5	1.1	-0.6	0.3	0.6	-0.9	-1.1	-0.9	0.3	0.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.9	-0.2	0.7	-0.3	0.0	0.2	0.1	-0.2	-1.0
Distance traveled before self-admin	0.7	0.7	1.4	0.7	-0.8	-0.6	1.2	1.1	1.1	0.2	0.5
Distance traveled after self-admin	0.3	0.3	0.9	1.0	-0.7	0.1	0.2	0.2	0.1	-0.5	0.6
Extensor digitorum longus weight	4.6	18.0	26.3	-2.5	2.2	-4.9	5.1	5.1	5.1	3.7	-4.0
Bone: elastic displacement	0.3	0.3	0.8	-0.4	-0.5	0.4	-0.6	-0.6	-0.6	0.9	0.3
Bone: elastic work	1.2	1.6	3.9	-1.8	0.2	-1.2	1.1	1.1	1.1	2.0	-0.6
Bone: endosteal estimation	1.1	2.5	5.2	1.5	1.2	1.6	-1.7	-1.7	-1.7	-2.3	0.1
Bone: endosteal perimeter	2.4	4.9	11.1	2.6	0.6	2.4	-2.2	-2.2	-2.2	-3.3	0.8
Epididymis fat weight	0.4	0.8	2.7	0.2	1.7	0.4	-0.7	-0.9	-0.8	-1.1	-0.7
Delta time in closed arm before/after self-admin	6.8	6.6	10.8	-3.0	2.1	-2.7	2.1	1.9	1.8	3.3	-3.1
Delta time in open arm before/after self-admin	1.0	1.0	2.5	1.3	-1.6	-0.1	0.8	0.9	0.9	-0.1	1.2
Diff in mean of infusions in LGA sessions	1.3	1.4	2.1	-0.9	-0.9	-1.2	1.4	1.5	1.5	1.0	0.8
Delay discount exponential model param	1.0	1.1	3.7	1.6	-1.9	0.9	-0.4	-0.5	-0.4	-0.1	1.1
Extinction: sum of active levers before priming	1.7	1.7	3.4	-0.5	-0.3	-1.5	1.8	1.8	1.7	1.1	-0.6
Active lever presses in extinction session 6	1.3	1.3	3.6	0.8	-1.9	-0.5	1.2	1.1	1.2	0.3	1.3
Bone: final force	0.7	1.2	2.5	-0.4	0.4	-1.1	1.5	1.5	1.6	1.0	-0.5
Bone: final moment	0.7	1.1	2.3	-0.4	0.4	-1.1	1.4	1.4	1.5	1.0	-0.5
Food consumed during 24 hour testing period	0.6	0.8	1.6	1.0	-1.0	1.0	-0.7	-0.7	-0.7	-0.4	1.3
Glucose	1.5	2.2	4.0	0.4	1.4	1.6	-2.0	-2.0	-2.0	-1.0	-0.3
Heart weight	0.9	1.3	4.0	-1.5	2.0	-0.2	-0.7	-0.4	-0.6	0.3	-1.7
Delay discount hyperbolic model param	1.2	1.3	4.3	1.7	-2.1	0.9	-0.5	-0.5	-0.4	-0.1	1.3
Intermittent access intake day 1-15 change	3.0	3.0	5.0	1.9	-2.0	1.8	-1.4	-1.3	-1.5	-1.4	2.2
Intermittent access intake escalation	2.3	2.2	3.6	1.9	-1.9	1.5	-1.1	-1.1	-1.2	-1.2	1.8
Intermittent access intake escalation 2	1.2	1.1	3.3	1.3	-1.8	0.8	-0.3	-0.4	-0.3	-0.8	1.6
Intermitt. access day 1 inactive lever presses	1.8	1.9	4.9	2.2	0.4	1.3	-1.1	-1.5	-1.4	-1.7	-0.5
Intermitt. access day 15 inactive lever presses	0.7	0.7	2.8	1.7	0.9	0.3	0.1	-0.1	-0.2	-1.1	-0.9
Intermitt. access escalation Index	1.1	1.0	3.3	-1.2	1.8	-0.3	-0.2	-0.1	-0.2	0.2	-1.7
Intermittent access day 1 total infusions	1.3	1.5	4.2	1.1	2.0	0.5	-0.7	-0.6	-0.7	-0.8	-2.0
Intermittent access day 15 total infusions	3.0	3.4	6.1	2.5	-0.2	2.2	-2.0	-2.0	-2.0	-2.0	0.5
Intermittent access terminal intake (last 3 days)	1.2	1.3	4.7	2.2	-0.1	1.3	-1.0	-0.9	-0.9	-1.2	0.1
Intermittent access total infusions	1.1	1.2	3.5	1.9	0.5	1.2	-1.0	-0.9	-1.0	-1.3	-0.4
Intermittent access day 1 locomotion	1.5	1.6	6.6	0.2	2.6	-0.4	0.1	0.1	0.1	-0.1	-2.4
Intermittent access day 15 total locomotion	0.7	0.8	4.0	2.0	0.5	0.5	-0.1	-0.3	-0.4	-1.0	-0.8
Intermittent access total locomotion	1.2	1.4	3.9	2.0	1.7	0.5	-0.2	-0.2	-0.3	-1.3	-1.5
Intermittent access standard deviation	2.5	2.7	5.5	2.2	-2.3	1.6	-1.2	-1.3	-1.3	-0.5	1.8
Left kidney weight	0.3	1.0	3.8	-1.1	1.9	-0.8	0.5	0.4	0.4	-0.4	-1.2
Right kidney weight	0.2	0.6	2.1	-0.6	1.4	-0.7	0.5	0.4	0.5	-0.2	-1.1
Cocaine induced anxiety	0.2	0.2	0.4	0.6	-0.5	-0.1	0.4	0.4	0.4	0.6	0.1
Post-drug Anxiety	0.3	0.3	0.9	0.9	-0.6	-0.2	0.6	0.6	0.6	0.5	0.2
Baseline Anxiety	0.7	0.7	1.2	-0.6	0.4	-1.1	1.1	1.1	1.1	0.6	-0.4
Tail length	1.2	3.7	8.0	-2.8	0.5	-2.3	2.1	1.9	1.9	2.0	-0.6
Length with tail	2.0	7.1	11.0	-3.0	1.8	-3.3	3.1	3.0	3.0	1.8	-1.6
Length without tail	1.2	2.6	3.8	-1.5	1.5	-1.9	1.9	1.9	2.0	0.6	-1.2
Times rat made contact with spout	0.3	0.3	0.9	-0.8	-0.4	-0.5	0.5	0.4	0.5	1.0	-0.1
Lifetime Intake	0.7	0.8	1.9	1.4	0.9	0.8	-0.8	-0.8	-0.8	-0.7	-0.9
Liver weight, left	0.2	0.4	0.7	-0.6	0.3	0.5	-0.6	-0.8	-0.8	-0.2	0.6
Liver weight, right	0.2	0.3	1.1	-0.3	1.0	0.1	-0.1	-0.2	-0.1	0.7	-0.7
Locomotor activity	0.5	0.7	3.2	-1.8	1.1	-0.0	-0.4	-0.6	-0.6	0.8	-0.2
Locomotor testing distance	0.5	0.9	2.5	-1.6	1.5	-0.0	-0.4	-0.6	-0.6	1.0	-0.8
Locomotor testing rearing	0.4	0.6	1.3	0.3	-0.1	1.0	-1.1	-1.0	-1.1	0.1	0.4
Locomotion in novel chamber	3.0	3.7	6.1	2.5	-0.6	2.2	-1.9	-1.9	-1.9	-2.2	1.4
Locomotion in novel chamber post-restriction	0.9	1.0	2.0	0.3	-0.7	1.2	-1.4	-1.4	-1.4	-0.5	0.7
Fecal boli incidents, locomotor time 1	2.5	2.7	8.6	2.9	-2.0	1.6	-1.0	-0.9	-0.9	-1.3	1.4
Change in fecal boli incidents, locomotor task	2.5	2.3	8.3	-2.5	2.9	-0.6	-0.1	-0.4	-0.2	1.0	-1.6
Time >=10cm from walls, locomotor time 1	4.0	4.1	10.3	3.2	-1.1	2.2	-1.7	-1.8	-1.8	-2.5	0.9
Bouts of movement, locomotor time 1	1.5	1.7	8.5	0.9	-2.9	0.1	0.3	0.3	0.3	0.1	1.9
Total resting periods, locomotor time 1	1.5	1.6	6.9	1.1	-2.6	0.2	0.3	0.2	0.2	-0.4	2.1
Rest time, locomotor task time 1	1.0	1.1	2.0	0.8	-0.8	1.1	-0.8	-1.3	-1.3	-1.4	0.8
Distance moved, locomotor task time 1	0.2	0.3	0.6	0.1	0.6	-0.4	0.2	0.5	0.4	0.7	-0.8
Vertical activity count, locomotor time 1	0.3	0.3	1.1	-0.1	0.2	0.6	-1.0	-0.8	-0.8	-0.0	0.1
Time >=10cm from walls, locomotor time 2	1.8	1.9	3.4	1.7	-1.7	1.3	-1.1	-0.8	-0.7	-1.5	1.8
Bouts of movement, locomotor time 2	1.3	1.4	2.7	1.1	-1.4	-0.6	1.4	1.2	1.1	1.6	-0.5
Total resting periods, locomotor time 2	1.0	1.1	2.1	1.4	-1.4	-0.3	1.1	0.8	0.7	1.4	-0.5
Rest time, locomotor task time 2	1.5	1.7	3.1	1.3	-0.5	1.5	-1.4	-1.8	-1.8	-0.9	-0.5
Distance moved, locomotor task time 2	0.3	0.3	1.2	-0.3	-0.7	-0.3	0.3	0.7	0.5	0.0	1.1
Vertical activity count, locomotor time 2	0.5	0.5	3.2	-1.8	-0.2	-0.3	-0.2	0.0	0.1	0.6	0.6
Light reinforcement 1	0.4	0.8	2.1	0.8	-0.8	0.9	-0.8	-0.6	-0.6	-0.8	1.4
Light reinforcement 2	1.5	2.0	4.8	1.6	-0.6	1.3	-1.0	-0.9	-0.9	-2.2	2.0
Bone: marrow area	1.2	2.6	5.5	1.4	1.3	1.6	-1.8	-1.8	-1.8	-2.3	0.1
Bone: maximum diameter	0.1	0.3	1.2	0.8	0.0	0.2	0.1	0.1	0.2	-1.1	0.5
Bone: maximum force	0.9	1.6	3.0	-0.2	1.1	-1.3	1.7	1.7	1.7	0.5	-0.9
Bone: maximum moment	0.9	1.5	2.8	-0.2	1.1	-1.2	1.6	1.6	1.7	0.5	-0.9
Mean time between licks in bursts	1.8	2.5	4.9	-1.6	1.1	-1.5	1.3	1.1	1.2	2.2	-2.2
Mean num. licks in bursts	0.1	0.2	0.9	-0.1	-0.7	0.1	-0.1	-0.1	-0.1	0.9	0.2
Cd content in liver	1.0	1.1	2.1	1.0	-0.6	1.4	-1.2	-1.2	-1.2	-0.7	0.9
Co content in liver	1.4	1.7	2.9	0.6	-1.7	1.4	-1.5	-1.5	-1.5	-0.2	1.2
Cu content in liver	1.0	1.3	2.8	-1.7	0.9	-1.2	0.7	0.8	0.8	1.2	-1.3
Fe content in liver	0.0	0.0	0.1	0.3	-0.0	-0.0	-0.0	0.1	0.1	0.2	-0.4
K content in liver	0.6	0.6	1.3	-0.2	1.2	-0.8	0.8	0.9	0.8	-0.3	-0.7
Mg content in liver	0.5	0.5	2.1	-0.0	1.4	-0.4	0.4	0.5	0.5	0.2	-1.1
Mn content in liver	1.0	1.2	2.0	-1.0	0.5	-1.4	1.4	1.4	1.4	-0.1	-0.6
Na content in liver	0.1	0.1	0.2	0.5	-0.2	-0.1	0.5	0.4	0.5	0.2	-0.1
Rb content in liver	0.7	0.9	1.7	0.5	0.6	1.1	-1.3	-1.3	-1.3	-0.7	-0.1
Se content in liver	0.2	0.3	0.9	0.5	-0.1	-0.4	0.5	0.5	0.4	-1.0	-0.5
Sr content in liver	5.3	4.8	6.8	-1.2	0.2	-2.4	2.6	2.6	2.5	2.6	-2.3
Zn content in liver	2.5	2.8	5.0	-0.1	0.2	-1.7	2.1	2.1	2.1	2.2	-1.1
Bone: minimum diameter	1.0	1.8	4.3	1.6	0.9	1.4	-1.3	-1.3	-1.3	-2.1	0.1
Time in familiar zone, hab. session 1	0.2	0.2	0.8	0.9	-0.5	0.3	-0.1	-0.1	-0.1	-0.4	0.1
Time in novel zone, hab. session 1	0.7	0.7	1.3	0.3	-0.4	1.0	-1.1	-1.1	-1.1	-0.2	0.5
Total zone transitions, hab. session 1	0.5	0.7	1.5	-1.1	0.2	-0.9	0.8	0.8	0.8	1.2	-0.5
Total locomotion distance, hab. session 1	0.1	0.2	0.4	0.7	0.6	0.1	-0.0	-0.0	-0.0	0.4	-0.6
Locomotion velocity, hab. session 1	0.3	0.5	1.0	-0.0	0.7	-0.6	0.6	0.6	0.6	1.0	-0.9
Time in familiar zone, hab. session 2	1.0	1.0	1.5	0.7	-1.2	1.1	-1.0	-1.0	-1.0	-0.9	1.2
Time in novel zone, hab. session 2	1.3	1.3	1.9	-0.8	1.3	-1.1	1.0	1.0	1.0	1.4	-1.2
Total zone transitions, hab. session 2	1.4	1.8	3.8	-1.2	1.0	-1.2	1.3	1.3	1.3	1.9	-1.2
Total locomotion distance, hab. session 2	0.3	0.4	1.2	-0.0	0.8	-0.3	0.4	0.4	0.4	1.0	-1.1
Locomotion velocity, hab. session 2	0.2	0.3	1.0	0.1	0.9	-0.2	0.2	0.2	0.3	0.7	-1.0
Novel to familiar place preference ratio	2.8	2.9	4.4	-2.1	1.5	-2.1	1.8	1.8	1.8	1.3	-1.1
Novelty place preference	1.9	1.9	3.3	-1.8	1.3	-1.7	1.4	1.4	1.4	0.9	-0.9
Time in novel zone, NPP test	2.0	2.1	3.2	-1.6	1.3	-1.8	1.5	1.5	1.5	1.1	-1.2
Total zone transitions, NPP test	1.5	2.2	3.9	-1.6	0.6	-1.5	1.5	1.5	1.5	2.0	-1.2
Total locomotion distance, NPP test	0.7	0.9	1.5	-1.2	1.1	-0.8	0.6	0.6	0.6	1.2	-1.2
Locomotion velocity, NPP test	0.5	0.7	2.2	-1.5	0.9	-0.7	0.5	0.5	0.5	0.9	-0.7
Intraocular pressure	0.3	0.4	1.7	0.8	-1.3	0.5	-0.4	-0.4	-0.4	-0.2	0.5
Delta distance traveled before/after self-admin	0.3	0.3	0.7	-0.2	0.2	0.5	-0.8	-0.7	-0.8	0.1	-0.3
Delta ambulatory time before/after self-admin	0.3	0.3	0.9	-0.5	0.3	0.5	-0.8	-0.8	-0.9	0.1	-0.2
Parametrial fat weight	1.5	2.9	8.3	1.5	0.8	1.6	-1.7	-1.8	-1.8	-2.9	0.4
Pavlov. Cond. lever latency	0.4	0.5	0.9	0.5	-0.9	0.7	-0.9	-0.9	-1.0	-0.4	0.2
Pavlov. Cond. magazine entry latency	0.3	0.4	1.4	1.2	-0.3	-0.1	0.7	0.7	0.7	-0.6	0.2
Pavlov. Cond. change in total contacts	0.4	0.4	1.8	1.3	-0.8	0.4	0.1	0.1	0.1	-0.6	0.8
Pavlov. Cond. index score	0.2	0.2	0.6	0.8	-0.5	0.1	0.4	0.4	0.4	-0.4	0.6
Pavlov. Cond. latency score	0.1	0.1	0.2	0.5	-0.1	0.1	0.3	0.3	0.4	-0.4	0.5
Pavlov. Cond. lever contacts	0.0	0.1	0.1	-0.0	0.4	-0.0	0.2	0.2	0.2	-0.2	0.3
Pavlov. Cond. magazine entry number	0.6	0.7	2.0	-1.4	1.4	-0.2	-0.4	-0.4	-0.5	0.7	-1.0
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.6	-0.4	-0.6	0.0	0.1	0.1	0.2	0.5	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	0.7	-0.5	-0.1	0.6	0.6	0.6	-0.2	0.5
Pavlov. Cond. response bias	0.3	0.4	1.3	1.1	-0.8	0.1	0.5	0.5	0.5	-0.5	0.7
Pavlov. Cond. lever latency	0.5	0.7	4.3	-2.1	0.5	-0.2	-0.3	-0.3	-0.2	0.8	0.1
Pavlov. Cond. magazine entry latency	1.9	2.2	4.4	2.1	-1.6	-0.9	1.8	1.8	1.8	0.5	-0.0
Pavlov. Cond. change in total contacts	1.9	2.6	12.4	3.5	-2.2	0.7	0.5	0.4	0.4	-0.9	1.3
Pavlov. Cond. index score	1.6	2.1	9.5	3.1	-1.7	-0.1	1.1	1.1	1.1	-0.5	0.4
Pavlov. Cond. latency score	1.5	1.8	8.8	3.0	-1.5	-0.1	1.0	1.1	1.1	-0.6	0.3
Pavlov. Cond. lever contacts	1.0	1.4	7.5	2.7	-1.7	0.6	0.1	0.1	0.1	-0.6	0.5
Pavlov. Cond. magazine entry number	2.8	3.4	6.0	-2.1	1.5	1.4	-2.4	-2.4	-2.4	-0.9	0.3
Pavlov. Cond. intertrial magazine entries	0.8	1.0	2.2	-0.4	0.1	1.1	-1.5	-1.3	-1.4	-1.0	0.5
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.3	10.0	3.2	-1.9	-0.1	1.2	1.2	1.2	-0.4	0.5
Pavlov. Cond. response bias	1.1	1.4	6.6	2.6	-1.6	-0.0	0.9	0.9	0.9	-0.2	0.2
Time in closed arm before self-admin	0.9	1.0	2.3	1.4	-0.7	0.8	-0.4	-0.3	-0.5	-1.5	1.4
Time in closed arm after self-admin	0.2	0.3	0.6	-0.6	0.8	-0.1	-0.4	-0.3	-0.5	0.2	-0.8
Time in open arm before self-admin	1.6	1.8	6.5	-2.5	1.5	-0.5	-0.3	-0.4	-0.3	1.5	-1.6
Time in open arm after self-admin	0.2	0.3	0.9	-0.6	-0.9	-0.1	0.2	0.1	0.3	0.5	0.6
Bone: periosteal estimation	0.3	0.7	2.6	1.0	0.6	0.7	-0.5	-0.5	-0.5	-1.6	0.4
Bone: periosteal perimeter	0.3	0.5	1.6	1.3	-0.0	0.8	-0.4	-0.4	-0.4	-1.1	0.5
Bone: post-yield work	1.3	1.8	5.8	1.9	1.0	1.2	-0.9	-0.8	-0.9	-2.4	0.6
Progressive ratio test 1 active lever presses	1.1	1.2	1.6	1.2	-0.3	1.2	-1.2	-1.2	-1.2	-1.3	0.7
Progressive ratio test 1 breakpoint	1.3	1.4	1.8	1.2	-0.5	1.3	-1.3	-1.3	-1.3	-1.3	0.9
Progressive ratio test 1 inactive lever presses	0.7	0.7	2.2	0.1	1.3	-0.8	0.7	0.6	0.5	0.3	-1.5
Progressive ratio test 2 active lever presses	1.5	1.6	3.1	1.7	-0.0	1.4	-1.3	-1.2	-1.3	-1.5	0.5
Progressive ratio test 2 breakpoint	2.2	2.4	3.6	1.9	-0.3	1.8	-1.7	-1.5	-1.7	-1.9	0.9
Progressive ratio test 2 inactive lever presses	0.8	1.0	3.4	1.8	0.5	0.9	-0.7	-0.7	-0.7	-1.3	-0.4
Incentive Sensitization - Responses	0.1	0.1	0.3	0.4	0.3	0.1	-0.1	0.3	0.1	-0.5	0.1
Incentive Sensitization - Breakpoint	0.2	0.2	0.5	0.6	0.5	0.2	-0.1	0.1	-0.1	-0.7	-0.0
Sum of active levers in priming session hrs 5-6	1.3	1.3	5.3	1.4	-2.3	0.2	0.5	0.5	0.5	-0.4	1.5
Progressive ratio	0.3	0.4	1.7	1.3	-0.4	0.5	-0.3	-0.3	-0.3	-0.7	-0.1
Food seeking constrained by brief footshock	0.1	0.2	0.6	-0.6	0.4	-0.0	-0.1	-0.1	-0.2	0.8	-0.5
Seeking ratio, punishment vs. effort	0.9	1.1	3.9	-2.0	1.1	-0.8	0.4	0.4	0.4	1.4	-1.0
Retroperitoneal fat weight	1.3	4.2	6.7	-0.2	2.5	1.6	-2.3	-2.5	-2.5	-2.6	-0.7
Reaction time number correct	0.3	0.4	1.3	-0.8	0.0	-0.6	0.7	0.6	0.6	1.1	-0.1
Reaction time mean minus median	0.6	0.7	2.7	1.2	-1.6	0.2	0.4	0.3	0.3	-0.6	1.0
Reaction time mean minus median AUC	0.6	0.8	4.1	0.9	-2.0	0.3	0.2	0.1	0.1	-0.1	1.2
Reaction time num false alarms	0.6	0.8	4.4	-2.1	0.6	-0.5	-0.1	-0.1	0.0	0.8	-0.6
Reaction time num false alarms AUC	1.5	2.0	10.0	-3.2	0.9	-1.4	0.6	0.6	0.7	1.3	-0.8
Reaction time trials correct on left	0.3	0.4	1.3	-0.8	0.0	-0.6	0.7	0.6	0.6	1.1	-0.1
Reaction time trials on left	0.3	0.5	1.4	-0.8	-0.0	-0.6	0.7	0.7	0.6	1.2	-0.1
Reaction time mean	1.6	2.2	7.6	2.8	-2.2	1.2	-0.4	-0.5	-0.5	-1.1	1.3
Reaction time mean AUC	2.2	3.0	9.8	3.1	-2.4	1.5	-0.7	-0.8	-0.8	-1.4	1.5
Median of all reaction times	1.0	1.4	6.0	2.5	-1.7	0.9	-0.1	-0.3	-0.3	-0.9	0.9
Reaction time omissions	0.2	0.3	0.9	-0.6	-0.9	-0.3	0.4	0.3	0.3	-0.2	0.6
Reaction time false alarm rate	0.6	0.8	4.3	-2.1	0.9	-0.7	0.0	0.0	0.1	0.3	-0.7
Reaction time premature initiation rate	3.1	4.1	5.9	-1.8	1.9	-2.4	2.4	2.3	2.4	0.8	-1.7
Reaction time premature initiations	3.6	5.0	7.4	-2.2	1.5	-2.7	2.7	2.6	2.7	1.6	-1.5
Std. dev. reaction times	1.1	1.6	5.4	1.6	-2.3	0.9	-0.4	-0.5	-0.5	-0.9	1.6
Reaction time trials completed	0.3	0.5	1.4	-0.8	-0.0	-0.6	0.7	0.7	0.6	1.2	-0.1
Reaction time trials AUC	0.3	0.4	1.3	-0.8	0.1	-0.5	0.6	0.6	0.5	1.2	-0.2
Run reversals in cocaine runway, females	2.6	2.5	6.1	-1.9	2.5	-1.5	0.9	1.0	1.2	0.8	-2.0
Run reversals in cocaine runway, males	0.5	0.5	1.4	-1.2	0.3	0.4	-0.6	-0.6	-0.6	-0.5	0.9
Latency to leave start box in cocaine runway	0.6	0.6	1.8	0.0	1.3	0.4	-0.6	-0.6	-0.5	-1.3	-0.3
Latency to leave start box in cocaine runway, F	0.2	0.2	0.7	-0.1	0.8	-0.1	0.1	0.1	0.1	-0.7	-0.5
Latency to leave start box in cocaine runway, M	2.4	2.3	4.0	0.5	0.2	1.6	-1.9	-1.8	-1.8	-2.0	1.4
Std. dev. time between licks in bursts	0.3	0.3	0.8	-0.8	0.9	-0.1	-0.1	-0.3	-0.3	0.6	-0.6
Total sessions with >9 infusions	0.8	0.9	1.5	1.0	1.1	0.7	-0.9	-1.0	-1.1	-0.5	-1.2
Short access day 1 total inactive lever presses	0.5	0.6	1.2	0.3	1.1	0.5	-0.8	-0.8	-0.7	-0.6	-1.0
Short access day 10 total inactive lever presses	0.9	1.0	2.4	0.1	0.6	0.9	-1.3	-1.6	-1.4	-0.2	-0.7
Short access day 1 total infusions	0.4	0.4	0.8	0.3	0.8	0.5	-0.7	-0.7	-0.7	0.2	-0.9
Short access day 10 total infusions	1.1	1.2	4.6	0.9	2.1	0.1	-0.3	-0.2	-0.3	-0.3	-2.1
Short access total infusions	0.6	0.7	2.8	0.4	1.6	0.0	-0.3	-0.3	-0.3	0.3	-1.7
Short access day 1 locomotion	0.6	0.7	1.9	-0.3	1.3	-0.7	0.6	0.5	0.3	0.8	-1.4
Short access day 10 total locomotion	0.7	0.8	2.9	0.8	1.6	-0.2	0.1	0.3	0.1	-0.2	-1.7
Short access total locomotion	1.2	1.3	4.2	0.4	1.9	-0.8	0.8	0.6	0.6	0.3	-2.0
One hour access (0.3 mA shock)	2.9	3.4	5.1	2.2	-0.1	2.1	-2.3	-2.1	-2.1	-1.9	0.3
Compulsive drug intake	2.0	2.0	5.7	-2.4	0.3	-1.6	1.1	1.1	1.3	1.9	-0.5
One hour access (shock baseline)	5.3	6.2	9.5	3.1	-1.1	2.9	-2.6	-2.6	-2.5	-2.9	1.5
Social response proportion	0.3	0.4	1.7	-1.3	0.7	-0.4	0.2	0.5	0.2	-0.0	0.5
Social responses	0.3	0.4	1.7	-1.3	-0.3	-0.3	0.2	0.3	0.1	0.3	1.0
Social time	0.4	0.5	1.9	-1.3	-0.4	-0.4	0.1	0.3	0.1	1.4	0.3
Soleus weight	2.1	6.1	9.0	1.8	-1.0	3.0	-3.0	-3.0	-2.9	-2.1	2.3
Bone: stiffness	0.1	0.2	0.4	0.5	-0.2	-0.2	0.6	0.6	0.6	-0.4	0.6
Tibialis anterior weight	7.7	26.3	38.2	-3.9	1.8	-5.9	6.2	6.1	6.2	5.0	-4.2
Time to tail flick, vehicle, before self-admin	0.6	0.7	1.7	-0.2	1.3	-0.7	0.7	0.8	0.8	0.1	-1.2
Time to tail flick, vehicle, after self-admin	1.1	1.2	2.7	-0.6	1.3	-1.1	1.0	0.9	0.8	1.1	-1.7
Time to tail flick, test, before self-admin	2.6	2.6	7.1	-2.2	2.7	-1.3	0.6	0.7	0.9	0.6	-2.2
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.4	-0.2	0.2	-0.4	-0.3	-0.3	-0.2	0.5
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.4	-0.4	0.1	-0.3	0.3	0.1	0.1	0.6	-0.2
Delta time to tail flick, test, before/after SA	2.0	1.8	6.7	1.4	-2.6	0.8	-0.3	-0.4	-0.4	-0.2	2.2
Tibia length	0.5	1.4	3.2	0.2	0.1	-1.2	1.8	1.7	1.8	0.3	0.2
Ambulatory time before self-admin	1.1	1.1	2.4	1.3	-1.5	-0.1	0.9	0.9	0.9	-0.3	1.5
Ambulatory time after self-admin	0.6	0.6	3.0	1.7	-0.4	0.5	0.0	0.1	-0.2	-1.1	0.6
Bone: tissue strength	0.5	0.5	0.8	0.5	-0.4	0.9	-0.8	-0.8	-0.8	-0.7	0.7
Total heroin consumption	2.5	2.9	4.5	-1.4	-1.1	-1.9	2.1	2.1	2.1	1.9	0.0
Bone: trabecular number	0.3	0.5	0.8	-0.2	0.9	-0.7	0.8	0.8	0.8	0.1	-0.8
Bone: trabecular spacing	0.5	0.6	1.7	0.7	-1.3	0.8	-0.6	-0.6	-0.6	0.7	0.7
Bone: trabecular thickness	0.7	0.9	2.1	1.0	-0.4	1.0	-0.9	-0.9	-0.9	-1.4	0.7
Bone: trabecular tissue density	2.6	3.7	5.3	1.1	-1.1	2.2	-2.3	-2.3	-2.3	-1.8	1.8
Water consumed over 24 hours	0.2	0.3	0.4	-0.7	-0.3	-0.6	0.5	0.6	0.6	0.3	0.3
Number of responses in last shaping day	0.4	0.5	1.2	-0.8	0.4	-0.7	0.5	0.4	0.3	1.1	-0.8