Adam10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Adam10	0.5	0.23	5.0e-13	0.14	0.14	0.15	0.14	6.4e-13	5.1e-13	8.0e-14	1.3e-12
2	BLA	mRNA stability	Adam10	0.12	0.09	3.0e-06	0.09	0.09	0.09	0.09	9.9e-06	2.4e-05	1.3e-05	1.1e-05
3	Adipose	mRNA stability	Adam10	0.1	0.07	3.6e-12	0.09	0.09	0.09	0.09	1.8e-10	1.7e-10	1.8e-10	1.9e-10
4	Brain	gene expression	Adam10	0.19	0.13	0.0e+00	0.21	0.22	0.22	0.22	1.5e-19	6.8e-20	6.9e-20	8.7e-20
5	NAcc	gene expression	Adam10	0.02	0.02	3.2e-03	0.02	0.01	0.01	0.01	4.3e-03	9.5e-03	9.4e-03	1.4e-02
6	PL	gene expression	Adam10	0.05	0.05	1.3e-04	0.04	0.03	0.03	0.03	5.8e-05	1.2e-04	1.0e-04	1.2e-04
7	OFC	mRNA stability	Adam10	0.17	0.15	4.7e-03	0.09	0.07	0.07	0.08	4.5e-03	8.9e-03	9.2e-03	7.2e-03
8	PL	mRNA stability	Adam10	0.21	0.14	1.4e-14	0.13	0.13	0.13	0.13	3.7e-14	1.5e-14	2.3e-14	2.1e-14
9	IL	gene expression	Adam10	0.35	0.24	1.1e-05	0.18	0.17	0.18	0.17	3.6e-05	7.5e-05	5.0e-05	6.5e-05
10	pVTA	gene expression	Adam10	0.1	0.12	6.9e-03	0.05	0.04	0.04	0.05	3.0e-03	8.1e-03	9.3e-03	3.4e-03
11	IL	mRNA stability	Adam10	0.25	0.2	2.8e-04	0.1	0.09	0.08	0.08	1.8e-03	3.6e-03	5.3e-03	5.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.5	0.8	1.1	0.3	1.0	0.9	0.9	-1.0	-0.9	1.1	-0.8	-0.9	-0.9	0.9
Area under the delay curve	0.1	0.1	1.0	1.0	-0.1	0.1	0.1	-0.1	-0.1	-0.3	-0.3	-0.1	-0.1	0.2
BMI with tail	4.6	14.9	19.9	-2.7	-4.2	-4.1	-4.1	3.7	3.8	-4.5	3.8	3.7	3.7	-4.0
BMI without tail	2.4	4.9	5.8	-2.2	-2.4	-2.4	-2.3	2.0	2.0	-2.4	2.3	1.9	1.9	-2.3
Body weight	4.2	17.6	19.8	-3.3	-4.2	-4.3	-4.4	4.1	4.2	-4.4	4.2	4.2	4.2	-4.5
Weight adjusted by age	6.2	7.0	9.5	-3.1	-2.7	-2.7	-2.7	2.6	2.6	-2.5	2.7	2.6	2.6	-2.4
Bone surface	0.1	0.1	0.5	-0.7	-0.1	-0.3	-0.3	0.2	0.2	-0.2	0.3	0.2	0.2	-0.3
Bone volume	0.0	0.0	0.2	-0.4	0.1	-0.0	-0.0	-0.1	-0.1	0.1	0.1	-0.1	-0.1	-0.0
Breakpoint value in progressive ratio session	0.5	0.6	0.8	-0.8	-0.9	-0.7	-0.7	0.7	0.8	-0.7	0.7	0.7	0.8	-0.8
Number of licking bursts	2.0	2.3	2.6	1.0	1.6	1.5	1.5	-1.6	-1.6	1.5	-1.5	-1.6	-1.6	1.6
Context. condit. distance diff. score	1.0	1.2	1.5	1.2	1.2	1.1	1.1	-0.9	-1.1	1.1	-1.1	-1.0	-1.0	1.1
Locomotion velocity, session 1	2.3	2.5	6.8	-2.6	-1.2	-1.3	-1.3	1.6	1.6	-0.7	1.7	1.5	1.5	-1.5
Locomotion distance, session 1	0.2	0.3	0.8	-0.6	0.8	0.5	0.5	-0.2	-0.3	0.9	-0.2	-0.3	-0.3	0.4
Locomotion velocity, session 2	0.4	0.4	1.4	-1.2	-0.2	-0.5	-0.5	0.8	0.6	-0.1	0.7	0.7	0.7	-0.5
Locomotion distance, session 2	0.3	0.5	2.4	-1.5	-0.3	-0.4	-0.4	0.7	0.6	-0.1	0.7	0.7	0.7	-0.4
Locomotion velocity, session 3	0.1	0.1	0.5	-0.7	0.2	0.1	0.1	0.1	0.2	0.5	0.2	0.0	0.0	-0.1
Locomotion distance, session 3	1.6	1.8	3.0	0.9	1.5	1.4	1.4	-1.2	-1.3	1.7	-1.2	-1.3	-1.3	1.2
Stereotopy head waving bouts, day 3	0.4	0.5	0.9	-0.3	-0.9	-0.8	-0.8	0.5	0.8	-0.9	0.6	0.6	0.6	-0.7
Stereotopy head waving duration, day 3	0.5	0.6	1.2	-0.2	-0.9	-0.9	-0.9	0.7	0.8	-1.1	0.7	0.7	0.7	-0.7
Locomotion velocity, session 7	1.4	1.5	2.8	0.4	1.1	1.4	1.4	-1.2	-1.2	1.7	-1.1	-1.3	-1.3	1.2
Locomotion distance, session 7	1.3	1.7	2.1	1.0	1.0	1.4	1.4	-1.2	-1.3	1.4	-1.3	-1.3	-1.3	1.4
Stereotopy head waving bouts, day 7	0.8	0.9	1.8	-0.0	-1.3	-1.1	-1.1	0.7	0.9	-1.4	0.7	0.9	0.9	-1.0
Stereotopy head waving duration, day 7	0.7	0.9	1.6	0.0	-1.3	-1.0	-1.1	0.7	0.9	-1.3	0.7	0.8	0.8	-0.9
Locomotion velocity, session 8	0.7	0.8	2.5	-1.6	-0.7	-0.6	-0.6	0.9	0.9	-0.2	1.0	0.9	0.9	-0.8
Locomotion distance, session 8	0.4	0.6	1.4	0.1	1.1	0.9	0.9	-0.5	-0.7	1.2	-0.7	-0.6	-0.6	0.9
Degree of sensitization distance	0.2	0.2	0.5	0.7	0.1	0.4	0.4	-0.5	-0.5	0.1	-0.5	-0.5	-0.5	0.6
Degree of sensitization stereotypy	0.5	0.6	1.0	-0.2	-1.0	-0.8	-0.8	0.7	0.7	-1.0	0.6	0.7	0.7	-0.8
Conditioned locomotion	0.1	0.1	0.1	0.1	0.2	0.3	0.3	-0.4	-0.3	0.3	-0.3	-0.3	-0.3	0.3
Cocaine response after cond. corrected	3.2	3.6	4.0	-1.7	-2.0	-2.0	-2.0	1.8	1.9	-2.0	1.9	1.9	1.9	-1.9
Cocaine response after cond. not corrected	1.8	2.0	2.2	-1.4	-1.4	-1.4	-1.4	1.4	1.4	-1.5	1.5	1.4	1.4	-1.4
Cocaine response before conditioning	1.1	1.3	1.7	1.1	1.3	1.2	1.2	-1.1	-1.1	1.1	-1.1	-1.1	-1.1	1.2
Saline control response	0.2	0.3	1.2	1.1	0.5	0.4	0.4	-0.6	-0.5	0.1	-0.6	-0.5	-0.5	0.5
Bone: connectivity density	0.9	1.5	2.2	0.6	1.5	1.2	1.3	-1.2	-1.1	1.4	-1.2	-1.2	-1.2	1.2
Bone: cortical apparent density	0.6	0.7	1.0	0.7	0.8	0.8	0.8	-1.0	-0.9	0.8	-0.9	-0.9	-0.9	0.8
Bone: cortical area	0.0	0.0	0.0	-0.1	0.2	0.0	0.0	0.1	0.0	0.1	-0.0	0.0	0.0	-0.1
Bone: cortical porosity	0.6	0.7	0.9	0.8	0.9	0.8	0.8	-1.0	-0.8	0.8	-0.8	-0.8	-0.8	0.7
Bone: cortical porosity	1.5	1.7	2.1	1.1	1.3	1.3	1.3	-1.4	-1.3	1.2	-1.3	-1.4	-1.4	1.2
Bone: cortical thickness	1.1	1.8	2.2	1.1	1.5	1.4	1.4	-1.4	-1.3	1.5	-1.4	-1.3	-1.3	1.3
Bone: cortical thickness	0.5	0.6	1.2	0.3	1.1	0.9	0.9	-0.7	-0.7	1.1	-0.7	-0.7	-0.7	0.8
Bone: cortical tissue density	0.5	0.7	1.0	0.8	0.8	0.8	0.8	-1.0	-0.8	0.8	-0.9	-0.9	-0.9	0.7
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	-0.3	0.3	0.1	0.0	0.1	0.1	0.2	0.1	0.1	0.1	-0.1
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.8	0.7	0.9	0.8	0.8	-0.6	-0.7	0.8	-0.7	-0.7	-0.7	0.8
Condit. Reinf. active responses	0.5	0.6	0.8	-0.9	-0.5	-0.7	-0.7	0.9	0.8	-0.6	0.9	0.9	0.9	-0.9
Condit. Reinf. inactive responses	1.4	1.7	2.1	-1.3	-1.2	-1.2	-1.3	1.4	1.2	-1.2	1.4	1.3	1.3	-1.4
Incentive salience index mean	0.1	0.1	0.4	-0.6	0.4	-0.0	-0.0	0.3	0.3	0.3	0.3	0.3	0.3	-0.2
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.5	0.5	0.1	0.1	0.2	0.1	0.6	0.1	0.1	0.1	-0.1
Condit. Reinf. active minus inactive responses	2.8	3.5	4.0	-2.0	-1.6	-1.9	-1.9	1.9	1.9	-1.6	2.0	1.8	1.8	-2.0
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.1	-0.9	-0.9	-1.0	-1.0	0.9	0.9	-1.0	1.0	0.9	0.9	-0.9
Condit. Reinf. active responses	1.5	2.1	3.5	-1.9	-1.0	-1.4	-1.4	1.5	1.5	-1.0	1.6	1.4	1.4	-1.6
Condit. Reinf. inactive responses	0.1	0.2	1.0	-1.0	0.5	0.0	0.1	0.1	0.2	0.5	0.3	0.2	0.2	-0.2
Condit. Reinf. lever presses	0.5	0.7	1.5	0.2	1.2	0.9	0.8	-0.7	-0.7	1.2	-0.7	-0.7	-0.7	0.7
Condit. Reinf. lever reinforcers received	0.9	1.2	2.2	-1.5	-0.7	-1.0	-1.0	1.1	1.2	-0.6	1.2	1.1	1.1	-1.2
Conditioned reinforcement - actives	0.3	0.3	2.3	1.5	-0.6	0.1	0.0	-0.2	-0.3	-0.7	-0.5	-0.3	-0.3	0.3
Conditioned reinforcement - inactives	0.0	0.0	0.3	0.6	-0.2	0.1	0.1	-0.0	-0.1	-0.2	-0.2	-0.1	-0.1	-0.0
Conditioned locomotion	0.5	0.6	0.9	0.9	0.6	0.7	0.7	-0.7	-0.8	0.4	-0.8	-0.8	-0.8	0.9
Patch foraging indifference point 0 sec	0.4	0.6	1.6	-1.3	-0.2	-0.7	-0.7	0.8	0.9	-0.2	0.8	0.9	0.9	-0.8
Patch foraging indifference point AUC	0.2	0.2	1.1	-1.0	-0.1	-0.2	-0.3	0.5	0.5	0.0	0.6	0.5	0.5	-0.5
Delay disc. indifference point, 0s delay	0.3	0.3	0.8	0.9	0.5	0.5	0.5	-0.5	-0.6	0.3	-0.6	-0.6	-0.6	0.5
Delay disc. indifference point, 16s delay	0.5	0.5	3.1	1.8	0.2	0.5	0.4	-0.6	-0.6	-0.2	-0.8	-0.6	-0.6	0.6
Delay disc. indifference point, 2s delay	0.1	0.1	0.8	0.9	0.0	0.3	0.2	-0.3	-0.3	0.0	-0.5	-0.3	-0.3	0.4
Delay disc. indifference point, 24s delay	0.4	0.4	1.6	1.3	0.7	0.5	0.5	-0.4	-0.5	0.3	-0.7	-0.4	-0.4	0.6
Delay disc. indifference point, 4s delay	0.3	0.3	1.5	1.2	0.1	0.4	0.3	-0.4	-0.4	-0.0	-0.6	-0.4	-0.4	0.5
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.4	-0.4	-0.2	-0.2	0.2	0.2	-0.4	0.0	0.2	0.2	-0.1
Indifference point function ln k	0.2	0.2	0.5	-0.2	-0.6	-0.6	-0.6	0.4	0.4	-0.7	0.3	0.5	0.5	-0.4
Indifference point function log k	0.2	0.2	0.5	-0.2	-0.6	-0.6	-0.6	0.4	0.4	-0.7	0.3	0.5	0.5	-0.4
Patch foraging total patch changes 0 sec	0.5	0.8	2.0	-1.4	-0.3	-0.8	-0.8	0.9	0.9	-0.3	0.9	1.0	1.0	-1.0
Patch foraging total patch changes 12 sec	0.1	0.1	0.3	-0.6	0.3	0.0	-0.0	0.2	0.2	0.3	0.3	0.2	0.2	-0.3
Patch foraging total patch changes 18 sec	0.2	0.3	0.6	-0.8	-0.4	-0.5	-0.5	0.6	0.5	-0.4	0.6	0.6	0.6	-0.6
Patch foraging total patch changes 24 sec	0.6	0.7	3.8	-1.9	0.0	-0.4	-0.4	0.7	0.8	0.2	0.9	0.7	0.7	-0.6
Patch foraging total patch changes 6 sec	0.7	1.0	2.4	-1.5	-0.5	-0.8	-0.8	1.0	1.1	-0.5	1.1	1.0	1.0	-1.0
Patch foraging time to switch 0 sec	1.7	2.6	4.2	2.0	1.2	1.5	1.5	-1.7	-1.7	1.1	-1.7	-1.7	-1.7	1.6
Patch foraging water rate 0 sec	2.7	4.3	6.1	-2.5	-1.7	-2.0	-2.0	2.1	2.2	-1.7	2.2	2.1	2.1	-2.0
Patch foraging water rate 12 sec	4.5	6.9	10.6	-3.3	-2.2	-2.6	-2.6	2.7	2.7	-2.0	2.8	2.7	2.7	-2.6
Patch foraging water rate 18 sec	0.5	0.7	1.7	-1.3	-0.3	-0.8	-0.8	0.8	0.9	-0.5	0.9	0.9	0.9	-0.7
Patch foraging water rate 24 sec	0.4	0.6	1.6	-1.3	-0.7	-0.7	-0.7	0.7	0.8	-0.4	0.8	0.7	0.7	-0.8
Patch foraging water rate 6 sec	1.3	2.0	2.4	-1.4	-1.0	-1.4	-1.4	1.6	1.5	-1.2	1.5	1.5	1.5	-1.3
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	1.4	-0.4	-1.2	-0.9	-0.9	0.9	0.9	-1.0	0.8	0.9	0.9	-0.8
Distance traveled before self-admin	0.8	0.9	6.1	2.5	-0.6	0.1	0.1	-0.6	-0.7	-0.9	-0.8	-0.6	-0.7	0.4
Distance traveled after self-admin	1.0	1.1	2.0	-0.1	-1.3	-1.1	-1.1	1.0	0.9	-1.4	0.8	1.0	0.9	-1.2
Extensor digitorum longus weight	7.7	30.1	33.9	-4.6	-5.8	-5.6	-5.6	5.4	5.4	-5.7	5.5	5.4	5.4	-5.7
Bone: elastic displacement	0.3	0.3	0.4	-0.6	-0.6	-0.6	-0.6	0.4	0.5	-0.6	0.6	0.5	0.5	-0.6
Bone: elastic work	0.0	0.0	0.1	-0.3	-0.1	-0.2	-0.2	-0.1	0.1	-0.0	0.1	0.0	0.0	-0.2
Bone: endosteal estimation	2.2	4.8	5.7	-1.9	-2.1	-2.2	-2.2	2.4	2.2	-2.2	2.2	2.2	2.2	-2.2
Bone: endosteal perimeter	3.5	7.3	8.6	-2.4	-2.6	-2.7	-2.7	2.9	2.7	-2.7	2.7	2.7	2.7	-2.7
Epididymis fat weight	0.0	0.0	0.1	-0.2	0.0	-0.2	-0.2	0.1	0.0	-0.1	0.3	0.1	0.1	-0.3
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.4	-0.3	0.3	0.3	-0.4	-0.4	0.2	-0.4	-0.4	-0.4	0.4
Delta time in open arm before/after self-admin	0.6	0.6	1.1	0.1	1.0	0.8	0.8	-0.7	-0.7	1.0	-0.6	-0.7	-0.7	0.6
Diff in mean of infusions in LGA sessions	0.9	1.0	1.5	-0.3	-1.2	-1.0	-1.0	1.1	1.1	-1.2	0.9	1.1	1.1	-0.9
Delay discount exponential model param	0.1	0.1	1.0	-1.0	0.2	0.0	0.1	-0.0	-0.0	0.5	0.2	-0.1	-0.1	-0.1
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.3	0.3	0.2	0.2	-0.0	-0.0	0.1	-0.2	-0.0	-0.0	0.3
Active lever presses in extinction session 6	0.2	0.2	1.5	1.2	-0.1	0.3	0.3	-0.4	-0.3	-0.2	-0.5	-0.4	-0.3	0.4
Bone: final force	0.6	0.9	1.6	-1.3	-0.8	-0.9	-0.9	1.0	1.0	-0.7	1.0	0.9	0.9	-1.1
Bone: final moment	0.2	0.3	0.8	-0.9	-0.4	-0.5	-0.5	0.7	0.6	-0.3	0.6	0.5	0.5	-0.7
Food consumed during 24 hour testing period	0.6	0.7	1.2	-0.0	-0.9	-0.9	-0.9	0.8	0.9	-1.1	0.7	0.8	0.8	-0.9
Glucose	0.7	1.1	2.3	-1.5	-0.6	-1.0	-0.9	1.1	1.1	-0.6	1.2	1.1	1.1	-1.0
Heart weight	0.3	0.4	0.8	-0.2	-0.8	-0.7	-0.7	0.5	0.4	-0.9	0.5	0.5	0.5	-0.7
Delay discount hyperbolic model param	0.1	0.1	1.2	-1.1	0.1	-0.1	-0.1	0.1	0.1	0.3	0.3	0.1	0.1	-0.2
Intermittent access intake day 1-15 change	1.3	1.3	1.5	1.2	1.0	1.1	1.1	-1.0	-1.2	0.9	-1.2	-1.2	-1.2	1.2
Intermittent access intake escalation	1.9	1.8	2.4	1.6	1.2	1.3	1.3	-1.4	-1.4	1.0	-1.4	-1.4	-1.4	1.5
Intermittent access intake escalation 2	0.2	0.2	1.2	1.1	0.0	0.2	0.2	-0.3	-0.4	-0.2	-0.5	-0.4	-0.4	0.5
Intermitt. access day 1 inactive lever presses	1.7	1.8	2.9	1.1	1.7	1.3	1.3	-1.4	-1.3	1.3	-1.3	-1.3	-1.3	1.2
Intermitt. access day 15 inactive lever presses	0.6	0.6	3.3	1.8	0.3	0.5	0.5	-0.7	-0.7	-0.0	-0.9	-0.7	-0.7	0.6
Intermitt. access escalation Index	1.1	1.0	1.4	-0.6	-1.0	-1.0	-1.0	1.0	1.0	-1.2	1.0	1.0	1.0	-1.1
Intermittent access day 1 total infusions	0.5	0.6	1.4	1.2	0.2	0.7	0.7	-0.7	-0.8	0.4	-0.9	-0.8	-0.8	0.7
Intermittent access day 15 total infusions	2.1	2.4	4.5	2.1	0.9	1.5	1.4	-1.5	-1.6	1.0	-1.7	-1.6	-1.6	1.6
Intermittent access terminal intake (last 3 days)	1.0	1.1	2.9	1.7	0.4	0.9	0.9	-1.1	-1.1	0.4	-1.2	-1.1	-1.1	1.0
Intermittent access total infusions	0.5	0.6	1.4	1.2	0.3	0.7	0.7	-0.7	-0.8	0.3	-0.8	-0.8	-0.8	0.8
Intermittent access day 1 locomotion	2.3	2.4	2.8	1.7	1.3	1.6	1.5	-1.5	-1.6	1.4	-1.6	-1.6	-1.6	1.6
Intermittent access day 15 total locomotion	2.0	2.2	3.2	1.2	1.2	1.5	1.5	-1.5	-1.6	1.3	-1.6	-1.6	-1.6	1.8
Intermittent access total locomotion	0.2	0.2	0.4	0.6	0.2	0.3	0.3	-0.4	-0.5	0.1	-0.5	-0.5	-0.5	0.6
Intermittent access standard deviation	2.0	2.1	3.7	1.9	1.0	1.4	1.4	-1.4	-1.6	1.0	-1.6	-1.6	-1.6	1.5
Left kidney weight	2.0	5.7	8.0	-1.4	-2.7	-2.5	-2.5	2.2	2.3	-2.8	2.2	2.3	2.3	-2.5
Right kidney weight	2.7	7.5	9.2	-2.0	-2.6	-2.7	-2.8	2.8	2.8	-2.8	2.7	2.8	2.8	-3.0
Cocaine induced anxiety	0.1	0.2	0.5	0.6	0.7	0.3	0.3	-0.4	-0.4	0.2	-0.4	-0.4	-0.4	0.2
Post-drug Anxiety	1.6	1.8	2.8	1.0	1.7	1.4	1.4	-1.3	-1.3	1.4	-1.3	-1.3	-1.3	1.2
Baseline Anxiety	0.3	0.3	0.4	0.3	0.5	0.6	0.6	-0.5	-0.5	0.7	-0.5	-0.5	-0.5	0.6
Tail length	0.2	0.5	1.8	-1.4	-0.7	-0.7	-0.7	0.5	0.5	-0.3	0.8	0.6	0.6	-0.6
Length with tail	1.1	4.0	4.7	-1.9	-1.8	-2.0	-2.0	2.0	2.1	-1.6	2.0	2.2	2.2	-2.1
Length without tail	2.1	4.6	5.8	-0.9	-2.1	-2.1	-2.2	2.3	2.4	-2.2	1.9	2.4	2.4	-2.2
Times rat made contact with spout	0.6	0.6	1.3	1.2	0.6	0.6	0.6	-0.9	-0.9	0.3	-0.9	-0.9	-0.9	0.8
Lifetime Intake	0.5	0.6	1.1	1.1	0.3	0.8	0.7	-0.7	-0.8	0.5	-0.9	-0.8	-0.8	0.8
Liver weight, left	1.0	1.6	2.8	-1.7	-0.7	-1.2	-1.2	1.2	1.3	-0.9	1.4	1.3	1.3	-1.3
Liver weight, right	2.6	4.4	6.5	-2.5	-1.6	-1.9	-1.9	2.2	2.2	-1.5	2.3	2.2	2.2	-2.2
Locomotor activity	5.5	8.7	10.4	-2.2	-3.2	-3.1	-3.1	2.9	3.0	-3.2	2.9	2.9	2.9	-2.9
Locomotor testing distance	2.7	4.5	5.5	-1.7	-2.2	-2.3	-2.3	2.1	2.1	-2.3	2.1	2.1	2.1	-2.0
Locomotor testing rearing	1.6	2.5	3.1	-1.5	-1.7	-1.7	-1.6	1.6	1.5	-1.6	1.5	1.6	1.6	-1.4
Locomotion in novel chamber	0.8	1.0	1.6	1.1	1.1	1.1	1.0	-0.9	-0.9	0.9	-1.1	-0.9	-0.9	1.3
Locomotion in novel chamber post-restriction	0.5	0.6	1.6	1.3	0.6	0.7	0.7	-0.7	-0.7	0.5	-0.9	-0.7	-0.7	0.6
Fecal boli incidents, locomotor time 1	0.1	0.1	1.0	1.0	0.2	0.2	0.1	-0.0	-0.0	-0.0	-0.3	0.1	0.0	0.1
Change in fecal boli incidents, locomotor task	0.3	0.3	1.6	-1.3	-0.4	-0.4	-0.4	0.3	0.4	-0.1	0.6	0.3	0.3	-0.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.0	-0.3	-0.4	-0.4	0.5	0.4	-0.5	0.2	0.4	0.4	-0.3
Bouts of movement, locomotor time 1	0.2	0.2	0.4	-0.5	-0.6	-0.4	-0.4	0.3	0.4	-0.2	0.4	0.3	0.3	-0.4
Total resting periods, locomotor time 1	0.1	0.2	0.4	-0.6	-0.6	-0.4	-0.4	0.3	0.3	-0.2	0.3	0.3	0.3	-0.3
Rest time, locomotor task time 1	0.0	0.0	0.2	-0.5	-0.2	-0.0	0.0	-0.1	-0.1	0.1	0.0	-0.1	-0.0	0.1
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.2	0.5	0.3	0.3	-0.3	-0.3	0.3	-0.2	-0.3	-0.3	0.2
Vertical activity count, locomotor time 1	0.3	0.3	0.9	0.9	0.6	0.4	0.4	-0.5	-0.5	0.2	-0.5	-0.5	-0.5	0.4
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.5	-0.7	0.2	-0.1	-0.1	0.4	0.3	0.2	0.3	0.3	0.3	-0.3
Bouts of movement, locomotor time 2	1.4	1.5	2.4	-0.4	-1.5	-1.4	-1.3	1.3	1.1	-1.6	1.1	1.1	1.1	-1.1
Total resting periods, locomotor time 2	1.5	1.6	2.8	-0.5	-1.7	-1.4	-1.4	1.3	1.1	-1.6	1.1	1.1	1.1	-1.1
Rest time, locomotor task time 2	0.2	0.2	0.4	0.6	0.1	0.4	0.4	-0.4	-0.5	0.4	-0.5	-0.4	-0.4	0.5
Distance moved, locomotor task time 2	0.1	0.1	0.4	-0.7	0.2	0.1	0.1	-0.1	0.1	0.4	0.1	0.0	0.0	-0.0
Vertical activity count, locomotor time 2	0.7	0.8	1.5	1.2	0.9	0.8	0.8	-0.9	-0.8	0.5	-1.0	-0.9	-0.8	0.9
Light reinforcement 1	2.9	5.3	6.3	-2.5	-1.9	-2.3	-2.3	2.3	2.4	-2.0	2.4	2.4	2.4	-2.3
Light reinforcement 2	0.1	0.2	0.6	-0.1	0.7	0.5	0.5	-0.4	-0.4	0.8	-0.2	-0.3	-0.3	0.2
Bone: marrow area	2.3	4.9	5.9	-1.9	-2.2	-2.2	-2.2	2.4	2.3	-2.2	2.2	2.3	2.3	-2.2
Bone: maximum diameter	2.2	4.0	4.5	-1.9	-1.9	-2.0	-2.0	2.1	2.0	-1.9	2.0	2.0	2.0	-2.0
Bone: maximum force	0.6	1.0	1.1	-1.1	-1.0	-1.0	-1.0	1.0	1.0	-0.9	1.0	0.9	0.9	-1.0
Bone: maximum moment	0.2	0.3	0.5	-0.7	-0.6	-0.6	-0.6	0.6	0.6	-0.5	0.6	0.5	0.5	-0.7
Mean time between licks in bursts	0.3	0.4	0.6	0.8	0.6	0.6	0.6	-0.7	-0.7	0.5	-0.7	-0.7	-0.7	0.7
Mean num. licks in bursts	0.8	0.9	1.4	-0.3	-1.1	-1.0	-1.0	1.0	1.0	-1.2	0.8	1.0	1.0	-1.0
Cd content in liver	0.1	0.1	0.3	0.5	0.3	0.3	0.3	-0.4	-0.3	0.2	-0.4	-0.4	-0.4	0.6
Co content in liver	0.0	0.0	0.1	-0.2	0.1	0.1	0.1	-0.1	-0.1	0.3	-0.1	-0.1	-0.1	0.1
Cu content in liver	0.4	0.5	0.7	-0.9	-0.6	-0.6	-0.6	0.7	0.7	-0.6	0.8	0.7	0.7	-0.8
Fe content in liver	0.4	0.5	0.6	0.5	0.8	0.7	0.7	-0.8	-0.7	0.7	-0.7	-0.8	-0.8	0.6
K content in liver	2.2	2.2	2.6	-1.5	-1.3	-1.5	-1.5	1.5	1.5	-1.3	1.5	1.5	1.5	-1.6
Mg content in liver	3.8	3.9	4.2	-1.9	-1.9	-2.0	-2.0	2.0	2.0	-1.9	2.0	2.0	2.0	-2.1
Mn content in liver	0.0	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.0	0.1	-0.2	0.0	-0.0	-0.0	-0.1
Na content in liver	3.0	3.2	5.0	-2.2	-1.4	-1.8	-1.8	1.7	1.7	-1.5	1.9	1.8	1.8	-2.0
Rb content in liver	1.5	1.8	2.6	-1.3	-1.6	-1.4	-1.4	1.3	1.3	-1.4	1.3	1.3	1.3	-1.2
Se content in liver	0.4	0.5	0.7	0.5	0.8	0.7	0.7	-0.7	-0.6	0.7	-0.6	-0.7	-0.7	0.7
Sr content in liver	0.0	0.0	0.0	-0.0	0.2	0.1	0.1	-0.1	-0.1	0.2	-0.0	-0.1	-0.1	0.0
Zn content in liver	0.3	0.3	0.4	0.6	0.7	0.6	0.6	-0.6	-0.5	0.6	-0.6	-0.5	-0.5	0.4
Bone: minimum diameter	0.0	0.0	0.3	0.5	0.2	0.1	0.1	0.1	-0.0	0.0	-0.2	-0.0	-0.0	0.1
Time in familiar zone, hab. session 1	0.1	0.1	0.9	-1.0	0.3	0.0	0.1	-0.4	-0.0	0.4	0.1	-0.1	-0.1	0.1
Time in novel zone, hab. session 1	0.1	0.1	1.2	1.1	-0.1	0.2	0.2	0.1	-0.2	-0.1	-0.3	-0.1	-0.1	0.1
Total zone transitions, hab. session 1	0.4	0.6	1.2	-0.4	1.0	0.7	0.8	-0.7	-0.7	1.1	-0.5	-0.7	-0.7	0.7
Total locomotion distance, hab. session 1	0.0	0.1	0.2	-0.4	0.4	0.2	0.2	-0.0	-0.1	0.3	0.0	-0.1	-0.1	0.2
Locomotion velocity, hab. session 1	0.0	0.0	0.2	-0.5	0.2	-0.1	-0.1	0.2	0.1	0.0	0.2	0.1	0.1	-0.0
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.2	0.1	0.1	0.1	-0.3	-0.1	0.2	-0.0	-0.1	-0.1	0.0
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.4	0.2	0.2	0.2	-0.1	-0.3	0.3	-0.3	-0.2	-0.2	0.3
Total zone transitions, hab. session 2	0.5	0.6	2.1	-1.4	-0.4	-0.6	-0.6	0.8	0.7	-0.3	0.9	0.7	0.7	-0.7
Total locomotion distance, hab. session 2	0.9	1.2	1.8	-1.3	-0.7	-1.0	-1.0	1.2	1.1	-1.0	1.2	1.2	1.2	-1.0
Locomotion velocity, hab. session 2	0.5	0.6	1.2	-1.1	-0.4	-0.7	-0.7	0.9	0.8	-0.7	0.9	0.9	0.9	-0.7
Novel to familiar place preference ratio	0.9	0.9	1.4	-0.6	-1.1	-1.0	-1.0	1.2	0.9	-0.9	0.9	1.0	1.0	-0.9
Novelty place preference	1.0	1.0	1.4	-0.7	-1.1	-1.0	-1.0	1.2	1.0	-0.9	0.9	1.0	1.0	-1.0
Time in novel zone, NPP test	1.2	1.2	1.7	-0.8	-1.3	-1.1	-1.1	1.3	1.1	-1.0	1.0	1.1	1.1	-1.1
Total zone transitions, NPP test	0.4	0.5	2.3	-1.5	-0.2	-0.6	-0.6	0.7	0.7	-0.2	0.9	0.7	0.7	-0.6
Total locomotion distance, NPP test	0.8	1.1	2.3	-1.5	-0.6	-1.0	-1.0	1.1	1.0	-0.7	1.2	1.1	1.1	-1.0
Locomotion velocity, NPP test	0.3	0.5	1.5	-1.2	-0.2	-0.6	-0.6	0.7	0.6	-0.4	0.8	0.7	0.7	-0.6
Intraocular pressure	0.1	0.1	0.3	0.2	-0.6	-0.1	-0.1	0.1	0.1	-0.6	0.0	0.0	0.0	0.2
Delta distance traveled before/after self-admin	2.1	2.2	5.6	-2.4	-0.8	-1.3	-1.2	1.6	1.6	-0.7	1.6	1.6	1.6	-1.4
Delta ambulatory time before/after self-admin	1.1	1.2	3.9	-2.0	-0.4	-0.8	-0.8	1.1	1.1	-0.2	1.2	1.1	1.1	-1.1
Parametrial fat weight	0.1	0.1	0.5	-0.7	-0.3	-0.3	-0.3	0.4	0.3	-0.2	0.5	0.3	0.3	-0.3
Pavlov. Cond. lever latency	0.1	0.2	0.8	0.9	-0.2	0.3	0.4	-0.3	-0.3	-0.2	-0.5	-0.4	-0.4	0.5
Pavlov. Cond. magazine entry latency	0.5	0.7	1.6	0.1	1.1	0.9	0.9	-0.8	-0.7	1.3	-0.6	-0.7	-0.7	0.7
Pavlov. Cond. change in total contacts	0.0	0.0	0.2	0.0	0.4	0.0	-0.0	0.1	-0.0	0.3	-0.0	-0.0	-0.0	-0.1
Pavlov. Cond. index score	0.4	0.6	1.4	0.0	1.1	0.8	0.7	-0.7	-0.6	1.2	-0.6	-0.7	-0.7	0.5
Pavlov. Cond. latency score	0.2	0.2	0.9	-0.3	0.9	0.4	0.4	-0.4	-0.3	0.9	-0.2	-0.3	-0.3	0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.6	0.5	0.0	0.0	0.0	0.0	0.5	0.2	-0.0	-0.0	-0.2
Pavlov. Cond. magazine entry number	0.9	1.1	1.9	-0.7	-1.3	-1.1	-1.1	1.0	1.0	-1.4	1.0	1.0	1.0	-0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.5	-0.7	-0.3	-0.4	-0.4	0.5	0.4	-0.3	0.5	0.4	0.4	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.1	-0.2	0.9	0.6	0.6	-0.5	-0.5	1.1	-0.4	-0.5	-0.5	0.3
Pavlov. Cond. response bias	0.4	0.4	1.1	0.1	1.0	0.7	0.7	-0.5	-0.6	1.0	-0.5	-0.6	-0.6	0.5
Pavlov. Cond. lever latency	0.5	0.6	1.5	0.1	-1.2	-0.8	-0.8	0.7	0.7	-1.2	0.6	0.7	0.7	-0.6
Pavlov. Cond. magazine entry latency	3.0	3.4	5.0	1.3	2.2	1.9	1.9	-1.8	-1.8	2.1	-1.7	-1.8	-1.8	1.7
Pavlov. Cond. change in total contacts	0.3	0.4	0.9	0.4	0.9	0.7	0.7	-0.6	-0.6	0.8	-0.6	-0.6	-0.6	0.5
Pavlov. Cond. index score	0.8	1.0	2.0	0.3	1.4	1.0	1.0	-0.9	-0.9	1.3	-0.8	-0.9	-0.9	0.8
Pavlov. Cond. latency score	0.5	0.6	1.4	0.1	1.2	0.8	0.8	-0.7	-0.7	1.1	-0.6	-0.7	-0.7	0.6
Pavlov. Cond. lever contacts	0.1	0.2	0.6	-0.3	0.8	0.4	0.4	-0.3	-0.3	0.8	-0.3	-0.3	-0.3	0.3
Pavlov. Cond. magazine entry number	2.6	3.1	4.5	-1.1	-2.1	-1.9	-1.9	1.8	1.8	-2.0	1.6	1.7	1.7	-1.7
Pavlov. Cond. intertrial magazine entries	0.6	0.8	0.9	-0.8	-1.0	-0.9	-0.9	0.9	0.9	-0.8	0.9	0.9	0.9	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	2.1	0.3	1.4	1.1	1.1	-1.0	-1.0	1.4	-0.9	-1.0	-1.0	0.9
Pavlov. Cond. response bias	0.9	1.2	2.0	0.4	1.4	1.1	1.1	-1.1	-1.0	1.4	-0.9	-1.1	-1.1	1.0
Time in closed arm before self-admin	0.2	0.3	1.1	1.0	0.3	0.4	0.3	-0.3	-0.4	0.1	-0.6	-0.3	-0.4	0.8
Time in closed arm after self-admin	0.3	0.3	1.5	1.2	-0.2	0.3	0.4	-0.4	-0.5	-0.0	-0.7	-0.4	-0.5	0.8
Time in open arm before self-admin	0.7	0.8	1.8	-0.3	-0.9	-0.9	-0.9	0.8	0.8	-1.1	0.9	0.8	0.8	-1.3
Time in open arm after self-admin	0.1	0.1	0.4	-0.6	0.3	-0.0	-0.1	0.1	0.1	0.1	0.3	0.1	0.1	-0.6
Bone: periosteal estimation	1.4	2.8	3.5	-1.5	-1.5	-1.7	-1.7	1.9	1.7	-1.6	1.7	1.7	1.7	-1.7
Bone: periosteal perimeter	2.1	3.5	4.3	-1.6	-1.7	-1.9	-1.9	2.1	1.9	-1.8	1.9	1.9	1.9	-1.9
Bone: post-yield work	0.1	0.1	0.2	-0.0	-0.4	-0.4	-0.4	0.4	0.3	-0.4	0.2	0.3	0.3	-0.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	0.1	-0.5	-0.3	-0.3	0.3	0.3	-0.6	0.2	0.3	0.3	-0.2
Progressive ratio test 1 breakpoint	0.0	0.0	0.2	0.5	-0.1	0.1	0.1	-0.1	-0.1	-0.2	-0.2	-0.1	-0.1	0.3
Progressive ratio test 1 inactive lever presses	0.7	0.8	1.2	0.7	1.1	1.0	1.0	-0.8	-0.9	0.9	-0.8	-0.9	-0.9	0.8
Progressive ratio test 2 active lever presses	0.1	0.1	0.5	0.2	-0.7	-0.3	-0.3	0.2	0.2	-0.6	0.1	0.2	0.2	-0.1
Progressive ratio test 2 breakpoint	0.3	0.3	0.9	-0.2	-1.0	-0.5	-0.5	0.5	0.4	-0.7	0.4	0.4	0.4	-0.4
Progressive ratio test 2 inactive lever presses	0.8	1.0	2.4	1.5	0.8	0.9	0.9	-0.9	-1.0	0.7	-1.1	-1.0	-1.0	0.9
Incentive Sensitization - Responses	0.2	0.2	0.6	-0.1	-0.8	-0.5	-0.5	0.4	0.4	-0.6	0.3	0.4	0.4	-0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	-0.0	-0.6	-0.3	-0.3	0.2	0.2	-0.4	0.1	0.2	0.2	-0.2
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.0	-0.2	-0.1	-0.1	0.2	0.3	-0.0	0.1	0.2	0.3	-0.1
Progressive ratio	1.5	1.8	5.5	2.4	0.7	1.1	1.1	-1.4	-1.4	0.3	-1.5	-1.4	-1.4	1.2
Food seeking constrained by brief footshock	0.6	0.7	0.9	-0.9	-0.9	-0.8	-0.8	0.8	0.8	-0.9	0.9	0.8	0.8	-0.9
Seeking ratio, punishment vs. effort	5.0	6.1	12.1	-3.5	-1.9	-2.3	-2.3	2.5	2.5	-1.5	2.7	2.5	2.5	-2.5
Retroperitoneal fat weight	0.1	0.2	0.6	-0.8	-0.2	-0.5	-0.5	0.5	0.4	-0.3	0.6	0.4	0.4	-0.6
Reaction time number correct	1.6	2.4	3.2	-1.5	-1.8	-1.6	-1.5	1.6	1.6	-1.7	1.4	1.5	1.5	-1.2
Reaction time mean minus median	0.1	0.1	0.5	-0.4	0.4	0.3	0.3	-0.3	-0.2	0.7	-0.0	-0.3	-0.3	-0.2
Reaction time mean minus median AUC	0.4	0.5	1.7	-0.2	0.9	0.8	0.8	-0.7	-0.6	1.3	-0.5	-0.6	-0.6	0.3
Reaction time num false alarms	0.5	0.6	1.2	0.7	1.1	0.9	0.9	-0.7	-0.8	0.8	-0.8	-0.7	-0.7	0.7
Reaction time num false alarms AUC	0.1	0.1	0.6	0.2	0.8	0.4	0.4	-0.2	-0.3	0.5	-0.3	-0.2	-0.2	0.3
Reaction time trials correct on left	1.6	2.4	3.2	-1.5	-1.8	-1.6	-1.5	1.6	1.6	-1.7	1.4	1.5	1.5	-1.2
Reaction time trials on left	1.8	2.6	3.4	-1.6	-1.8	-1.6	-1.6	1.6	1.6	-1.7	1.5	1.6	1.6	-1.2
Reaction time mean	2.1	2.9	4.6	0.6	1.8	1.8	1.8	-1.9	-1.7	2.1	-1.5	-1.7	-1.7	1.5
Reaction time mean AUC	1.5	2.0	3.3	0.5	1.6	1.5	1.5	-1.6	-1.4	1.8	-1.2	-1.4	-1.4	1.2
Median of all reaction times	3.2	4.4	6.0	1.1	2.2	2.2	2.2	-2.3	-2.1	2.4	-1.9	-2.1	-2.1	2.0
Reaction time omissions	0.3	0.4	0.7	-0.7	-0.9	-0.7	-0.7	0.5	0.5	-0.6	0.7	0.5	0.5	-0.8
Reaction time false alarm rate	1.2	1.7	3.1	1.1	1.8	1.3	1.3	-1.2	-1.2	1.4	-1.2	-1.2	-1.2	1.0
Reaction time premature initiation rate	1.8	2.4	3.1	-1.6	-1.8	-1.6	-1.6	1.4	1.5	-1.5	1.6	1.5	1.5	-1.5
Reaction time premature initiations	3.2	4.5	5.7	-2.2	-2.4	-2.1	-2.1	2.0	2.1	-2.1	2.1	2.1	2.1	-1.9
Std. dev. reaction times	0.6	0.9	2.0	0.1	1.1	1.0	1.0	-1.1	-1.0	1.4	-0.7	-1.0	-1.0	0.6
Reaction time trials completed	1.8	2.6	3.4	-1.6	-1.8	-1.6	-1.6	1.6	1.6	-1.7	1.5	1.6	1.6	-1.2
Reaction time trials AUC	1.4	2.1	3.0	-1.4	-1.7	-1.5	-1.4	1.4	1.5	-1.6	1.3	1.4	1.4	-1.0
Run reversals in cocaine runway, females	0.0	0.0	0.1	-0.1	-0.2	-0.1	-0.1	0.2	0.2	-0.3	0.2	0.2	0.2	0.1
Run reversals in cocaine runway, males	0.1	0.1	0.3	-0.5	-0.1	-0.2	-0.2	0.2	0.2	-0.0	0.3	0.2	0.2	-0.1
Latency to leave start box in cocaine runway	1.6	1.8	2.7	-0.5	-1.4	-1.4	-1.5	1.3	1.3	-1.7	1.2	1.3	1.3	-1.4
Latency to leave start box in cocaine runway, F	0.2	0.2	0.5	0.1	-0.2	-0.5	-0.5	0.3	0.3	-0.7	0.4	0.3	0.3	-0.6
Latency to leave start box in cocaine runway, M	3.2	3.1	4.7	-0.9	-2.2	-1.8	-1.8	1.8	1.8	-2.1	1.6	1.8	1.8	-1.6
Std. dev. time between licks in bursts	0.5	0.6	1.6	-1.2	-0.4	-0.7	-0.7	0.8	0.8	-0.4	0.9	0.8	0.8	-0.8
Total sessions with >9 infusions	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1	-0.0	-0.1	0.1	-0.0	-0.1	-0.1	-0.0
Short access day 1 total inactive lever presses	0.0	0.1	0.1	0.1	0.3	0.3	0.3	-0.2	-0.2	0.2	-0.2	-0.2	-0.2	0.2
Short access day 10 total inactive lever presses	1.2	1.4	2.8	1.7	1.3	1.1	1.1	-1.1	-1.1	0.7	-1.2	-1.1	-1.1	1.2
Short access day 1 total infusions	0.4	0.4	0.9	1.0	0.1	0.6	0.6	-0.7	-0.7	0.3	-0.7	-0.7	-0.7	0.6
Short access day 10 total infusions	0.3	0.3	0.4	0.5	0.1	0.6	0.6	-0.6	-0.6	0.5	-0.6	-0.6	-0.6	0.4
Short access total infusions	0.7	0.7	0.9	0.8	0.5	0.9	0.9	-0.9	-0.9	0.8	-0.9	-0.9	-0.9	0.8
Short access day 1 locomotion	0.1	0.1	0.1	0.4	0.1	0.2	0.2	-0.2	-0.3	-0.1	-0.2	-0.3	-0.3	0.1
Short access day 10 total locomotion	0.0	0.0	0.1	-0.4	-0.1	-0.1	-0.1	0.0	0.1	-0.0	0.1	0.1	0.1	-0.2
Short access total locomotion	0.8	0.9	1.0	0.8	0.9	1.0	1.0	-1.0	-1.0	0.9	-0.9	-1.0	-1.0	0.7
One hour access (0.3 mA shock)	0.1	0.1	0.4	0.5	-0.6	-0.2	-0.2	0.1	0.1	-0.5	-0.0	0.1	0.1	0.0
Compulsive drug intake	0.7	0.7	1.7	-1.3	-0.8	-0.8	-0.8	0.8	0.8	-0.5	0.9	0.8	0.8	-0.8
One hour access (shock baseline)	0.8	0.9	2.8	1.7	0.5	0.8	0.8	-0.9	-0.9	0.3	-1.0	-0.9	-0.9	1.0
Social response proportion	0.4	0.4	1.3	1.1	0.6	0.5	0.4	-0.7	-0.7	0.3	-0.6	-0.7	-0.7	0.4
Social responses	0.1	0.2	0.3	-0.5	-0.0	-0.3	-0.3	0.4	0.4	0.1	0.5	0.4	0.4	-0.5
Social time	0.0	0.1	0.5	0.7	-0.3	-0.0	-0.0	-0.1	-0.0	-0.1	-0.2	0.0	0.0	-0.0
Soleus weight	16.4	47.9	50.4	-6.4	-7.0	-7.1	-7.0	6.9	6.9	-6.8	7.0	6.9	6.9	-7.1
Bone: stiffness	1.2	1.9	2.5	-1.0	-1.4	-1.4	-1.4	1.6	1.4	-1.4	1.3	1.4	1.4	-1.4
Tibialis anterior weight	12.3	42.1	44.8	-5.4	-6.7	-6.6	-6.6	6.5	6.6	-6.7	6.4	6.6	6.6	-6.7
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.5	-0.7	0.4	0.1	0.1	0.0	0.1	0.6	0.1	0.0	0.1	0.2
Time to tail flick, vehicle, after self-admin	0.4	0.5	2.2	1.5	0.1	0.5	0.5	-0.5	-0.6	0.0	-0.8	-0.5	-0.6	0.7
Time to tail flick, test, before self-admin	0.8	0.8	1.0	0.6	0.9	0.9	0.9	-0.9	-0.9	1.0	-0.8	-0.9	-0.9	0.8
Time to tail flick, test, after self-admin	3.5	3.6	9.3	3.1	1.3	1.6	1.6	-2.1	-2.1	0.7	-2.0	-2.1	-2.1	1.5
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	2.4	1.6	0.2	0.6	0.6	-0.7	-0.8	0.0	-0.9	-0.7	-0.8	0.5
Delta time to tail flick, test, before/after SA	0.2	0.2	1.2	1.1	0.1	0.1	0.1	-0.4	-0.4	-0.4	-0.4	-0.4	-0.4	0.1
Tibia length	0.1	0.3	0.4	0.7	0.6	0.5	0.4	-0.4	-0.6	0.5	-0.5	-0.5	-0.5	0.6
Ambulatory time before self-admin	0.6	0.6	3.4	1.8	-0.1	0.4	0.4	-0.7	-0.7	-0.3	-0.8	-0.7	-0.7	0.5
Ambulatory time after self-admin	0.5	0.6	0.9	-0.5	-0.8	-0.8	-0.7	0.8	0.7	-0.8	0.7	0.8	0.7	-0.9
Bone: tissue strength	1.7	1.7	2.1	1.3	1.2	1.3	1.3	-1.4	-1.3	1.3	-1.3	-1.3	-1.3	1.2
Total heroin consumption	1.6	1.9	3.7	-0.6	-1.9	-1.5	-1.4	1.1	1.3	-1.8	1.2	1.3	1.3	-1.4
Bone: trabecular number	1.4	2.2	3.0	0.6	1.7	1.5	1.5	-1.5	-1.5	1.7	-1.4	-1.5	-1.5	1.5
Bone: trabecular spacing	0.0	0.0	0.0	0.2	-0.2	-0.1	-0.1	0.1	0.1	-0.2	0.1	0.1	0.1	-0.1
Bone: trabecular thickness	0.3	0.3	0.4	0.3	0.5	0.5	0.5	-0.6	-0.6	0.5	-0.5	-0.6	-0.6	0.6
Bone: trabecular tissue density	5.7	8.0	9.4	-3.1	-2.8	-2.9	-2.8	2.7	2.9	-2.6	2.9	2.8	2.8	-2.8
Water consumed over 24 hours	0.5	0.6	1.2	1.1	0.9	0.8	0.7	-0.8	-0.8	0.5	-0.8	-0.8	-0.8	0.7
Number of responses in last shaping day	0.1	0.1	0.3	0.5	0.2	0.3	0.3	-0.3	-0.3	0.1	-0.3	-0.3	-0.3	0.4