Hub : Genes

Unc13c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Unc13c 0.09 0.05 1.2e-04 0.08 0.05 0.04 -0 3.9e-04 3.7e-03 7.8e-03 3.4e-01
2 NAcc mRNA stability Unc13c 0.03 0.02 1.5e-06 0.04 0.04 0.04 0.04 2.1e-06 3.1e-06 8.9e-07 1.4e-06
3 PL gene expression Unc13c 0.03 0.02 1.1e-03 0.03 0.02 0.02 0.03 8.9e-04 2.1e-03 6.0e-03 6.3e-04
4 OFC isoform ratio NM_173146.2 0.18 0.11 3.8e-03 0.08 0.07 0.05 0.06 5.5e-03 7.9e-03 2.8e-02 1.2e-02
5 NAcc gene expression Unc13c 0.09 0.04 0.0e+00 0.16 0.15 0.13 0.16 9.8e-23 1.4e-22 4.7e-19 5.3e-23
6 BLA mRNA stability Unc13c 0.1 0.07 1.1e-03 0.1 0.06 0.08 0.08 6.1e-06 4.0e-04 3.8e-05 4.2e-05
7 OFC gene expression Unc13c 0.21 0.11 9.2e-04 0.1 0.12 0.13 0.13 1.9e-03 7.6e-04 5.6e-04 5.9e-04
8 Brain alternative polyA NM_173146.2 0.04 0.03 4.9e-04 0.03 0.03 0.03 0.03 1.7e-03 7.9e-04 8.0e-04 4.7e-04
9 Brain alternative polyA XM_063264996.1 0.04 0.03 5.1e-04 0.03 0.03 0.03 0.03 9.8e-04 6.6e-04 7.3e-04 5.2e-04
10 Brain gene expression Unc13c 0.18 0.07 8.3e-15 0.12 0.17 0.14 0.16 1.4e-11 5.8e-16 1.0e-12 3.2e-15
11 Brain mRNA stability Unc13c 0.15 0.07 3.3e-07 0.06 0.08 0.06 0.06 1.7e-06 1.1e-07 6.0e-06 2.1e-06
12 pVTA mRNA stability Unc13c 0.05 0.04 4.7e-03 0.02 0.01 -0 0.01 1.3e-02 2.6e-02 8.8e-01 6.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.30.61.7-0.9-0.71.3-0.60.7-1.1-0.80.8-0.8-0.3-0.5-0.0
Area under the delay curve0.10.20.60.30.10.20.2-0.40.20.60.6-0.6-0.8-0.6-0.4
BMI with tail3.612.726.54.75.0-4.35.2-4.93.24.5-0.50.5-1.80.40.3
BMI without tail0.63.48.71.72.3-1.12.9-2.40.52.01.7-1.7-2.4-1.1-0.9
Body weight1.77.614.63.53.8-3.23.6-3.82.63.71.3-1.3-1.40.7-1.0
Weight adjusted by age1.44.07.22.32.6-2.22.4-2.72.62.7-1.41.4-0.7-0.00.6
Bone surface0.30.62.40.00.40.20.6-0.60.20.8-0.70.7-1.1-1.31.5
Bone volume0.10.20.9-0.00.30.30.4-0.3-0.30.4-0.00.0-0.8-0.80.9
Breakpoint value in progressive ratio session0.10.20.60.10.4-0.40.7-0.60.40.50.3-0.3-0.8-0.70.3
Number of licking bursts0.51.43.5-1.9-1.61.7-1.81.1-0.4-0.4-0.60.6-0.2-1.30.7
Context. condit. distance diff. score0.20.20.7-0.0-0.40.5-0.50.50.0-0.40.0-0.00.90.80.2
Locomotion velocity, session 10.30.40.80.40.6-0.50.8-0.60.10.6-0.30.3-0.9-0.70.8
Locomotion distance, session 10.91.12.7-1.3-0.91.4-0.50.8-1.4-0.90.7-0.7-1.3-1.60.0
Locomotion velocity, session 20.40.42.1-0.2-0.00.30.5-0.2-0.10.00.4-0.4-1.4-1.40.6
Locomotion distance, session 21.01.46.2-0.50.30.60.9-0.5-0.30.11.1-1.1-2.5-2.40.2
Locomotion velocity, session 30.60.73.9-0.8-0.00.40.2-0.00.10.10.1-0.1-1.6-2.01.2
Locomotion distance, session 31.92.25.3-2.3-1.71.8-1.51.6-1.7-1.31.1-1.1-0.9-1.6-0.0
Stereotopy head waving bouts, day 31.41.73.21.71.1-1.40.7-0.81.10.5-1.81.81.51.70.4
Stereotopy head waving duration, day 31.92.34.72.01.2-1.40.9-1.01.20.3-2.22.21.72.10.8
Locomotion velocity, session 70.40.41.2-0.7-0.71.0-0.50.7-0.8-1.10.4-0.4-0.2-0.50.2
Locomotion distance, session 70.81.12.3-1.4-1.11.5-0.80.8-1.2-0.80.8-0.8-0.9-1.40.3
Stereotopy head waving bouts, day 70.80.92.70.70.8-0.80.9-0.70.70.3-1.41.4-0.4-0.51.6
Stereotopy head waving duration, day 71.21.54.50.81.0-0.71.1-0.91.00.3-1.81.8-0.7-0.92.1
Locomotion velocity, session 80.91.13.60.20.60.11.0-0.70.90.4-0.70.7-1.6-1.91.8
Locomotion distance, session 80.71.03.8-1.0-0.61.4-0.10.3-0.3-0.40.7-0.7-1.6-1.90.8
Degree of sensitization distance0.10.10.30.2-0.20.4-0.1-0.00.1-0.2-0.50.50.30.10.2
Degree of sensitization stereotypy0.50.62.00.40.6-0.60.7-0.50.60.3-0.90.9-0.7-0.81.4
Conditioned locomotion0.91.04.3-0.2-0.10.2-0.20.20.0-0.12.1-2.10.10.6-1.9
Cocaine response after cond. corrected3.24.87.72.82.3-2.22.0-2.42.42.3-2.42.40.51.12.3
Cocaine response after cond. not corrected2.84.16.72.62.0-2.21.6-2.12.32.3-2.32.31.01.71.5
Cocaine response before conditioning0.70.84.3-0.7-0.80.4-0.80.5-0.10.21.3-1.30.10.1-2.1
Saline control response0.20.31.00.1-0.1-0.1-0.30.2-0.1-0.2-1.01.00.80.50.5
Bone: connectivity density1.52.46.4-2.0-1.62.5-1.31.6-2.0-1.61.0-1.0-0.8-1.6-0.0
Bone: cortical apparent density1.11.73.1-1.0-1.41.2-1.61.7-1.7-1.8-0.60.61.71.10.1
Bone: cortical area0.81.25.60.6-0.1-0.6-0.60.3-0.3-0.1-1.21.22.32.40.0
Bone: cortical porosity1.31.54.3-0.7-1.00.7-1.11.0-0.4-0.51.9-1.90.81.0-2.1
Bone: cortical porosity1.41.54.2-0.7-1.00.8-1.01.0-0.5-0.61.9-1.90.81.0-2.0
Bone: cortical thickness2.23.610.0-0.8-1.81.1-2.12.2-2.3-2.2-0.60.63.22.7-0.6
Bone: cortical thickness0.70.93.90.0-0.50.0-0.90.7-0.2-0.4-0.40.42.02.0-0.7
Bone: cortical tissue density1.01.63.0-1.0-1.41.2-1.51.6-1.7-1.7-0.60.61.50.90.1
Condit. Reinf. active minus inactive responses1.41.64.7-1.1-0.40.80.10.2-0.2-0.32.2-2.2-2.0-1.8-0.5
Condit. Reinf. active-inactive response ratio0.20.20.80.2-0.1-0.4-0.10.10.7-0.10.2-0.20.70.9-0.1
Condit. Reinf. active responses2.22.89.6-1.2-0.31.00.50.0-0.6-0.22.3-2.3-3.1-3.10.1
Condit. Reinf. inactive responses2.32.913.5-1.3-0.31.30.50.1-1.3-0.21.6-1.6-3.3-3.70.4
Incentive salience index mean1.41.86.1-0.7-0.10.40.4-0.20.40.42.5-2.5-2.1-1.8-1.1
Condit. Reinf. lever presses1.21.75.7-0.30.10.20.4-0.40.50.92.4-2.4-1.7-1.4-1.8
Condit. Reinf. active minus inactive responses1.01.53.01.21.3-1.11.3-1.31.00.9-1.71.7-0.4-0.21.7
Condit. Reinf. active-inactive response ratio1.01.64.51.41.1-1.00.9-0.90.70.4-2.12.10.80.91.6
Condit. Reinf. active responses0.30.50.90.51.0-0.50.9-1.00.80.90.0-0.0-0.9-0.50.2
Condit. Reinf. inactive responses1.21.75.2-1.4-0.71.0-0.50.5-0.3-0.02.3-2.3-1.3-1.3-1.7
Condit. Reinf. lever presses0.50.72.7-0.4-0.80.3-1.30.70.7-0.3-0.70.71.61.3-0.1
Condit. Reinf. lever reinforcers received0.20.20.50.30.7-0.40.6-0.70.60.70.1-0.1-0.6-0.30.0
Conditioned reinforcement - actives0.10.41.01.00.8-0.60.9-0.71.00.7-0.20.20.20.5-0.0
Conditioned reinforcement - inactives0.10.20.50.20.1-0.60.10.00.70.40.0-0.00.60.70.1
Conditioned locomotion0.40.62.50.1-0.1-0.00.00.4-0.4-0.21.3-1.30.61.0-1.6
Patch foraging indifference point 0 sec0.30.82.50.30.6-0.40.6-0.50.80.7-1.41.4-0.4-0.61.6
Patch foraging indifference point AUC1.02.47.3-1.3-0.71.4-0.30.5-0.5-0.22.7-2.7-1.8-1.7-1.8
Delay disc. indifference point, 0s delay1.92.26.6-1.5-1.01.8-0.60.6-1.4-0.71.5-1.5-2.2-2.60.5
Delay disc. indifference point, 16s delay0.30.41.2-0.1-0.50.6-0.50.6-0.4-0.60.4-0.40.80.8-1.1
Delay disc. indifference point, 2s delay0.10.10.4-0.3-0.20.5-0.2-0.0-0.10.10.4-0.4-0.5-0.60.1
Delay disc. indifference point, 24s delay0.40.71.7-0.5-0.70.8-0.90.7-0.8-0.51.3-1.30.20.2-1.1
Delay disc. indifference point, 4s delay0.20.20.4-0.1-0.30.3-0.1-0.1-0.10.40.7-0.7-0.6-0.60.3
Delay disc. indifference point, 8s delay0.71.22.90.80.9-0.61.0-1.41.31.70.4-0.4-1.6-1.2-0.3
Indifference point function ln k1.03.15.82.11.6-2.21.1-1.31.51.1-2.42.41.21.42.1
Indifference point function log k1.03.15.82.11.6-2.21.1-1.31.51.1-2.42.41.21.42.1
Patch foraging total patch changes 0 sec0.20.71.90.30.6-0.40.6-0.50.80.7-1.41.4-0.2-0.41.4
Patch foraging total patch changes 12 sec0.71.01.8-1.3-0.81.2-0.81.0-0.4-0.51.4-1.4-0.5-0.9-1.0
Patch foraging total patch changes 18 sec0.10.20.8-0.7-0.60.9-0.60.7-0.2-0.3-0.20.20.4-0.10.0
Patch foraging total patch changes 24 sec0.41.24.7-1.2-0.51.3-0.30.2-1.3-0.10.6-0.6-1.8-2.20.8
Patch foraging total patch changes 6 sec0.71.36.0-1.0-0.20.90.30.1-0.8-0.30.5-0.5-2.1-2.51.1
Patch foraging time to switch 0 sec0.20.61.1-0.5-0.80.5-1.00.8-0.7-1.1-0.80.81.00.50.5
Patch foraging water rate 0 sec0.51.83.91.61.6-1.61.8-1.61.62.0-0.50.5-0.40.10.8
Patch foraging water rate 12 sec0.52.13.91.51.8-1.61.5-1.71.41.5-1.41.4-0.7-0.42.0
Patch foraging water rate 18 sec0.10.11.00.10.1-0.10.30.0-1.0-0.40.1-0.1-0.00.2-0.1
Patch foraging water rate 24 sec0.40.61.4-0.8-0.80.6-0.20.8-1.1-0.6-0.70.7-0.4-0.91.2
Patch foraging water rate 6 sec0.30.40.80.50.7-0.40.8-0.60.80.9-0.10.1-0.7-0.70.9
Seeking ratio, delayed vs. immediate footshock2.53.66.72.12.4-1.82.6-2.41.92.5-0.80.8-1.6-1.01.3
Distance traveled before self-admin0.40.91.90.60.9-1.20.8-1.21.41.0-0.40.4-1.0-0.91.3
Distance traveled after self-admin1.73.15.22.31.9-2.21.7-2.12.22.3-1.31.30.10.61.5
Extensor digitorum longus weight4.417.737.25.25.9-5.26.1-5.64.15.0-0.40.4-3.0-0.81.6
Bone: elastic displacement0.20.31.10.00.00.30.2-0.0-0.7-0.30.9-0.9-0.30.1-1.0
Bone: elastic work0.20.30.90.2-0.10.1-0.10.2-0.1-0.30.9-0.90.60.9-0.8
Bone: endosteal estimation2.56.212.32.83.0-3.02.9-3.23.53.5-1.21.2-1.1-0.21.2
Bone: endosteal perimeter1.63.87.32.22.6-2.42.4-2.62.72.7-0.40.4-1.0-0.10.4
Epididymis fat weight0.31.53.4-1.0-0.61.3-0.20.7-1.1-1.21.8-1.8-1.2-1.1-1.4
Delta time in closed arm before/after self-admin1.31.22.8-0.9-0.60.2-1.21.0-0.4-0.81.4-1.41.21.3-1.7
Delta time in open arm before/after self-admin1.51.76.4-0.4-1.00.6-0.70.9-0.8-0.9-2.22.20.7-0.22.5
Diff in mean of infusions in LGA sessions1.12.04.31.81.7-2.12.0-1.71.81.60.0-0.0-0.30.6-0.6
Delay discount exponential model param0.20.20.6-0.3-0.1-0.1-0.20.5-0.3-0.7-0.60.60.80.60.3
Extinction: sum of active levers before priming0.00.10.1-0.3-0.1-0.00.00.20.3-0.1-0.30.30.30.10.3
Active lever presses in extinction session 61.21.23.10.81.1-0.91.8-1.31.21.1-0.70.7-1.0-0.81.4
Bone: final force0.40.61.41.10.7-1.00.7-0.80.70.8-0.20.20.71.20.1
Bone: final moment0.40.63.01.10.5-0.90.4-0.50.50.4-0.20.21.21.7-0.1
Food consumed during 24 hour testing period1.63.25.81.81.4-2.00.9-1.62.42.2-2.32.31.21.41.0
Glucose0.40.61.30.81.0-0.61.0-0.80.50.4-0.90.9-0.5-0.41.2
Heart weight0.50.83.0-0.30.10.80.5-0.3-0.60.11.1-1.1-1.7-1.50.4
Delay discount hyperbolic model param0.20.20.5-0.2-0.1-0.1-0.20.5-0.3-0.7-0.70.70.70.50.4
Intermittent access intake day 1-15 change0.10.51.30.30.4-0.10.3-0.91.01.0-0.10.1-1.1-1.00.7
Intermittent access intake escalation0.10.51.30.30.4-0.10.3-0.90.91.0-0.10.1-1.1-1.10.8
Intermittent access intake escalation 20.81.43.00.81.1-0.90.8-1.61.71.7-0.50.5-1.3-1.11.3
Intermitt. access day 1 inactive lever presses0.11.25.4-0.5-1.00.2-1.31.3-0.4-0.6-0.10.12.32.0-0.4
Intermitt. access day 15 inactive lever presses0.10.30.7-0.4-0.50.4-0.80.3-0.4-0.10.7-0.70.60.6-0.7
Intermitt. access escalation Index0.10.20.80.30.6-0.60.6-0.50.90.6-0.30.3-0.20.1-0.2
Intermittent access day 1 total infusions0.20.72.2-0.5-1.00.4-0.81.1-1.1-0.7-0.20.21.51.2-0.1
Intermittent access day 15 total infusions0.00.10.2-0.2-0.50.3-0.40.3-0.4-0.20.1-0.10.20.2-0.1
Intermittent access terminal intake (last 3 days)0.10.10.50.50.1-0.4-0.0-0.20.20.50.1-0.10.50.7-0.3
Intermittent access total infusions0.40.42.00.2-0.5-0.1-0.40.5-0.3-0.0-0.50.51.41.30.0
Intermittent access day 1 locomotion0.50.93.1-0.2-0.6-0.0-0.80.8-0.9-0.30.9-0.91.61.8-1.3
Intermittent access day 15 total locomotion0.10.52.70.4-0.0-0.4-0.20.1-0.10.30.3-0.31.31.6-0.8
Intermittent access total locomotion0.50.52.20.80.4-1.00.4-0.30.30.9-0.30.31.11.5-0.2
Intermittent access standard deviation0.00.20.90.50.2-0.4-0.1-0.40.60.90.2-0.20.20.3-0.4
Left kidney weight0.43.05.62.32.3-2.12.2-2.21.82.40.2-0.20.31.5-0.4
Right kidney weight0.32.14.91.62.1-1.52.2-2.01.52.00.3-0.3-1.0-0.00.1
Cocaine induced anxiety0.10.31.0-0.2-0.40.4-0.10.4-0.8-0.20.8-0.80.40.5-1.0
Post-drug Anxiety0.80.92.2-1.1-1.21.3-0.80.9-1.5-0.90.7-0.7-0.2-0.6-0.3
Baseline Anxiety0.50.82.9-1.0-0.80.9-0.50.4-0.6-0.9-0.50.5-1.1-1.71.0
Tail length0.63.46.2-2.2-1.72.4-1.51.4-2.2-1.32.5-2.5-1.0-1.3-1.3
Length with tail0.10.62.6-0.4-0.00.4-0.2-0.3-0.60.21.6-1.6-1.0-0.7-0.5
Length without tail0.94.79.52.82.8-3.02.0-3.02.93.1-0.50.5-0.30.90.7
Times rat made contact with spout0.40.41.0-0.5-0.90.5-1.00.6-0.6-0.1-0.50.51.00.70.5
Lifetime Intake0.30.31.60.1-0.40.0-0.20.6-0.4-0.1-0.50.51.31.10.1
Liver weight, left1.11.93.81.32.0-1.61.6-1.91.51.9-0.90.9-0.9-0.30.4
Liver weight, right0.81.53.01.61.6-1.41.7-1.61.11.6-0.60.6-0.60.10.1
Locomotor activity1.82.96.62.42.6-1.82.3-2.31.91.9-0.10.1-0.11.0-0.6
Locomotor testing distance0.71.74.12.02.0-1.21.8-1.61.31.0-0.60.60.31.00.1
Locomotor testing rearing0.10.41.31.11.1-0.51.1-0.60.20.30.2-0.20.00.40.5
Locomotion in novel chamber0.30.41.50.1-0.50.4-0.60.5-0.1-0.50.2-0.21.21.2-0.0
Locomotion in novel chamber post-restriction0.10.41.5-0.8-0.70.7-0.80.5-1.2-0.40.1-0.1-0.3-0.6-0.1
Fecal boli incidents, locomotor time 10.30.92.6-1.0-0.50.6-0.70.20.80.41.6-1.6-0.8-0.8-1.2
Change in fecal boli incidents, locomotor task3.33.511.01.81.2-1.71.3-1.01.10.9-3.33.31.11.02.4
Time >=10cm from walls, locomotor time 10.30.40.80.60.6-0.60.9-0.80.50.6-0.80.8-0.5-0.40.2
Bouts of movement, locomotor time 10.30.40.90.70.6-0.60.4-0.70.60.90.6-0.6-0.5-0.1-0.7
Total resting periods, locomotor time 10.20.20.70.60.4-0.60.2-0.40.60.90.3-0.3-0.10.2-0.5
Rest time, locomotor task time 10.30.62.30.1-0.40.1-0.70.60.50.10.7-0.71.31.5-0.7
Distance moved, locomotor task time 10.30.93.5-0.7-0.31.00.20.1-1.4-0.9-0.40.4-1.5-1.90.5
Vertical activity count, locomotor time 10.10.62.2-0.5-0.20.60.30.1-1.5-0.7-0.20.2-1.2-1.40.2
Time >=10cm from walls, locomotor time 20.10.21.90.0-0.10.10.10.0-0.20.10.5-0.50.40.6-1.4
Bouts of movement, locomotor time 20.20.61.80.30.50.71.0-0.4-0.8-0.11.0-1.0-1.4-1.0-0.4
Total resting periods, locomotor time 20.10.41.10.40.50.51.0-0.4-0.7-0.00.5-0.5-1.0-0.8-0.2
Rest time, locomotor task time 20.50.93.6-0.1-0.70.4-0.71.2-0.3-1.0-0.60.61.91.6-0.4
Distance moved, locomotor task time 20.70.95.2-0.6-0.00.60.4-0.4-0.5-0.1-0.10.1-2.0-2.30.8
Vertical activity count, locomotor time 20.30.72.3-1.2-0.81.1-0.60.4-0.9-0.50.0-0.0-1.0-1.50.0
Light reinforcement 10.62.95.41.32.2-1.32.3-2.31.62.21.2-1.2-2.1-1.1-0.3
Light reinforcement 20.40.84.20.2-0.4-0.1-0.70.50.3-0.40.1-0.11.92.0-1.0
Bone: marrow area2.66.412.82.83.1-3.02.9-3.23.63.5-1.31.3-1.0-0.01.2
Bone: maximum diameter1.32.76.01.91.9-2.11.5-2.01.62.4-1.31.30.20.91.2
Bone: maximum force0.40.71.51.20.9-1.20.9-0.90.71.0-0.40.40.51.00.2
Bone: maximum moment0.40.72.31.20.6-1.00.6-0.60.50.7-0.40.41.01.5-0.1
Mean time between licks in bursts0.10.51.0-0.7-0.80.8-1.01.0-0.3-0.70.2-0.20.80.3-0.5
Mean num. licks in bursts0.41.24.21.71.2-1.51.2-0.80.10.50.2-0.21.12.0-0.3
Cd content in liver3.53.97.0-2.4-1.72.4-1.11.5-2.7-1.62.4-2.4-1.8-2.2-0.5
Co content in liver1.92.24.8-1.5-1.41.6-1.31.3-1.7-1.02.2-2.20.10.0-1.7
Cu content in liver0.30.40.80.60.5-0.70.3-0.60.20.90.7-0.70.30.8-0.6
Fe content in liver0.50.63.20.10.30.10.4-0.4-0.30.4-0.70.7-0.9-1.11.8
K content in liver0.10.10.20.10.2-0.20.1-0.3-0.40.50.2-0.2-0.20.10.1
Mg content in liver0.30.41.10.60.8-0.90.6-0.80.31.10.0-0.0-0.30.00.4
Mn content in liver1.41.67.80.5-0.2-0.4-0.80.60.6-0.30.0-0.02.42.8-1.7
Na content in liver2.32.64.91.72.2-1.62.1-2.21.82.20.2-0.2-1.6-0.70.5
Rb content in liver0.60.71.90.81.0-0.70.9-1.00.40.9-0.50.5-0.6-0.41.4
Se content in liver0.50.61.2-0.7-0.80.5-1.10.9-1.1-0.8-0.80.80.90.40.8
Sr content in liver1.21.11.9-1.4-1.11.3-1.01.0-0.5-1.11.1-1.1-0.5-0.9-1.0
Zn content in liver0.30.41.40.1-0.0-0.1-0.10.2-0.6-0.21.2-1.20.40.7-0.9
Bone: minimum diameter0.40.73.70.60.1-0.7-0.2-0.00.20.50.4-0.41.41.9-1.1
Time in familiar zone, hab. session 10.10.10.3-0.2-0.00.0-0.1-0.10.40.60.4-0.4-0.3-0.2-0.4
Time in novel zone, hab. session 10.20.30.8-0.1-0.30.1-0.40.6-0.3-0.9-0.60.60.80.50.4
Total zone transitions, hab. session 12.02.85.2-2.1-1.32.3-0.81.3-2.0-1.71.5-1.5-1.7-2.2-0.3
Total locomotion distance, hab. session 11.21.63.8-1.5-0.81.7-0.30.9-1.8-1.40.9-0.9-1.6-1.90.5
Locomotion velocity, hab. session 10.60.92.7-0.9-0.41.10.10.4-1.1-0.80.8-0.8-1.4-1.60.4
Time in familiar zone, hab. session 20.10.10.4-0.5-0.60.4-0.60.5-0.2-0.1-0.30.30.1-0.30.1
Time in novel zone, hab. session 20.50.61.21.00.7-0.90.5-0.60.80.4-0.80.80.81.10.3
Total zone transitions, hab. session 22.32.98.3-1.5-0.41.90.30.3-1.5-0.82.1-2.1-2.9-2.9-0.6
Total locomotion distance, hab. session 22.12.86.4-1.3-0.31.80.20.4-1.3-0.72.5-2.5-2.5-2.4-0.8
Locomotion velocity, hab. session 21.92.67.0-1.3-0.31.60.20.4-1.2-0.72.7-2.7-2.2-2.1-1.1
Novel to familiar place preference ratio1.01.32.31.31.5-1.51.4-1.51.41.40.4-0.4-0.40.4-0.6
Novelty place preference1.31.62.91.51.7-1.71.5-1.71.71.70.2-0.2-0.30.6-0.6
Time in novel zone, NPP test1.62.03.81.81.8-1.91.6-1.81.91.8-0.50.50.00.9-0.1
Total zone transitions, NPP test0.91.34.1-1.1-0.51.60.10.3-1.2-0.71.1-1.1-1.9-2.00.1
Total locomotion distance, NPP test1.21.66.0-1.1-0.31.50.30.2-0.9-0.51.3-1.3-2.3-2.40.2
Locomotion velocity, NPP test1.82.68.0-1.6-0.61.9-0.00.6-1.2-0.91.8-1.8-2.6-2.8-0.1
Intraocular pressure0.20.30.9-0.6-0.50.6-0.40.8-0.8-0.9-0.30.3-0.0-0.30.1
Delta distance traveled before/after self-admin2.12.35.52.31.7-1.71.3-1.41.71.7-0.90.91.21.80.0
Delta ambulatory time before/after self-admin1.11.94.62.01.2-1.30.9-0.91.41.3-1.31.31.72.10.2
Parametrial fat weight2.35.511.0-2.9-2.72.7-2.62.6-3.3-2.52.0-2.00.1-0.5-1.6
Pavlov. Cond. lever latency1.51.95.30.70.0-0.5-0.40.30.0-0.6-2.32.32.32.11.3
Pavlov. Cond. magazine entry latency4.96.321.4-2.0-1.61.8-1.01.4-1.2-0.84.6-4.6-1.4-1.2-3.9
Pavlov. Cond. change in total contacts2.52.710.4-0.6-0.20.50.20.20.20.13.2-3.2-1.4-0.9-2.8
Pavlov. Cond. index score3.84.916.3-1.7-1.11.5-0.50.8-0.9-0.34.0-4.0-2.1-1.9-3.1
Pavlov. Cond. latency score3.34.313.9-1.6-1.01.5-0.50.8-0.9-0.33.7-3.7-2.1-1.9-2.8
Pavlov. Cond. lever contacts1.92.37.7-0.7-0.20.50.2-0.10.10.52.8-2.8-1.9-1.6-2.1
Pavlov. Cond. magazine entry number4.25.317.11.91.5-1.61.0-1.31.30.8-4.14.11.41.23.5
Pavlov. Cond. intertrial magazine entries1.21.56.5-0.40.10.40.5-0.3-0.8-0.1-1.21.2-1.5-2.02.6
Pavlov. Cond. lever-magazine prob. diff.3.84.716.2-1.5-0.91.4-0.30.6-0.7-0.04.0-4.0-2.3-2.0-3.1
Pavlov. Cond. response bias3.44.215.0-1.4-0.91.0-0.30.6-0.7-0.13.9-3.9-1.9-1.5-3.2
Pavlov. Cond. lever latency0.30.41.01.00.8-0.51.0-0.5-0.1-0.1-0.70.70.10.30.3
Pavlov. Cond. magazine entry latency3.24.69.9-2.6-2.92.2-3.12.8-1.9-2.61.0-1.01.50.7-1.3
Pavlov. Cond. change in total contacts0.61.53.5-1.7-1.71.2-1.91.5-1.5-1.10.7-0.70.4-0.0-0.4
Pavlov. Cond. index score1.11.74.7-1.9-1.91.4-2.21.6-0.9-1.20.7-0.70.6-0.0-0.7
Pavlov. Cond. latency score0.81.24.0-1.6-1.61.1-2.01.4-0.6-1.00.3-0.30.70.2-0.4
Pavlov. Cond. lever contacts0.20.31.0-0.9-0.70.5-1.00.40.20.20.6-0.6-0.0-0.2-0.4
Pavlov. Cond. magazine entry number2.43.27.62.32.6-2.02.7-2.31.72.1-0.40.3-1.1-0.20.4
Pavlov. Cond. intertrial magazine entries0.61.22.60.91.4-1.01.4-1.41.01.6-0.50.5-1.3-1.00.4
Pavlov. Cond. lever-magazine prob. diff.1.42.15.5-2.1-2.01.5-2.41.8-1.1-1.30.9-0.90.6-0.1-0.9
Pavlov. Cond. response bias1.52.14.1-2.0-1.91.5-2.01.6-1.1-1.21.6-1.60.2-0.3-1.0
Time in closed arm before self-admin0.10.10.20.10.00.50.1-0.3-0.10.10.2-0.2-0.5-0.4-0.5
Time in closed arm after self-admin0.91.03.3-0.8-0.40.7-0.50.6-0.6-1.01.5-1.50.20.3-1.8
Time in open arm before self-admin1.01.33.31.21.3-1.70.7-1.11.81.5-0.20.20.51.2-0.1
Time in open arm after self-admin1.31.43.81.00.4-1.20.5-0.41.10.9-1.91.91.00.91.7
Bone: periosteal estimation1.43.36.12.22.1-2.31.8-2.12.22.5-1.41.40.41.10.9
Bone: periosteal perimeter1.22.34.11.91.8-2.01.5-1.71.71.9-1.21.20.51.20.8
Bone: post-yield work0.40.71.80.30.7-0.10.6-0.91.11.3-0.50.5-1.0-1.10.8
Progressive ratio test 1 active lever presses0.20.31.00.1-0.30.30.00.5-0.3-0.3-0.70.71.00.9-0.1
Progressive ratio test 1 breakpoint0.20.31.10.1-0.30.2-0.10.6-0.2-0.2-0.70.71.00.9-0.2
Progressive ratio test 1 inactive lever presses0.41.03.2-0.7-1.20.6-1.01.4-0.7-0.6-0.60.61.81.20.5
Progressive ratio test 2 active lever presses0.50.71.81.21.0-1.01.3-0.80.90.7-0.60.60.00.40.1
Progressive ratio test 2 breakpoint0.40.51.51.10.9-0.81.2-0.60.80.6-0.60.6-0.00.30.1
Progressive ratio test 2 inactive lever presses0.10.42.30.2-0.3-0.1-0.40.40.1-0.1-0.50.51.51.40.1
Incentive Sensitization - Responses0.61.53.71.41.6-1.51.9-1.51.61.3-0.10.1-1.0-0.3-0.4
Incentive Sensitization - Breakpoint0.61.33.31.21.5-1.31.8-1.31.31.10.1-0.1-1.2-0.5-0.5
Sum of active levers in priming session hrs 5-60.80.82.80.90.7-0.80.6-0.70.90.6-1.21.20.10.01.7
Progressive ratio0.31.03.7-0.00.10.00.2-0.10.40.41.9-1.9-0.7-0.2-1.9
Food seeking constrained by brief footshock1.01.34.40.30.40.30.7-0.80.51.0-1.61.6-1.2-1.42.1
Seeking ratio, punishment vs. effort1.22.69.41.11.3-0.91.4-1.30.51.0-2.42.4-0.6-0.73.1
Retroperitoneal fat weight1.14.710.0-2.7-2.32.9-2.12.2-3.2-2.42.0-1.9-0.5-1.0-1.1
Reaction time number correct0.20.71.50.61.0-0.51.2-0.80.70.3-0.60.6-1.0-0.91.2
Reaction time mean minus median0.10.41.0-0.4-0.60.4-0.50.7-1.0-0.60.2-0.20.60.6-1.0
Reaction time mean minus median AUC0.10.71.5-0.7-1.10.7-1.01.1-1.2-1.0-0.10.10.90.7-0.6
Reaction time num false alarms0.30.61.8-0.7-0.61.0-0.50.7-1.4-1.3-0.20.20.2-0.20.7
Reaction time num false alarms AUC0.20.40.9-0.5-0.40.8-0.30.5-0.9-0.9-0.60.60.1-0.20.9
Reaction time trials correct on left0.20.71.50.61.0-0.51.2-0.80.70.3-0.60.6-1.0-0.91.2
Reaction time trials on left0.20.71.60.51.0-0.51.2-0.80.70.2-0.70.7-1.0-0.91.3
Reaction time mean0.81.83.2-1.1-1.71.1-1.81.6-1.8-1.50.3-0.31.61.3-1.0
Reaction time mean AUC0.51.22.8-1.0-1.40.9-1.41.3-1.7-1.20.2-0.21.21.0-0.7
Median of all reaction times1.52.44.2-1.4-2.01.3-2.01.9-1.9-1.70.4-0.41.81.4-1.0
Reaction time omissions0.10.21.0-0.6-0.20.3-0.20.4-0.8-1.0-0.30.3-0.2-0.5-0.1
Reaction time false alarm rate0.50.81.9-0.9-1.01.1-1.01.0-1.4-1.2-0.10.10.70.20.2
Reaction time premature initiation rate0.20.21.00.60.5-0.20.8-0.3-1.00.10.4-0.40.00.4-0.3
Reaction time premature initiations0.10.41.71.01.0-0.61.3-0.7-0.50.20.1-0.1-0.40.00.3
Std. dev. reaction times0.41.43.5-1.2-1.51.0-1.51.5-1.9-1.40.4-0.41.00.7-0.9
Reaction time trials completed0.20.71.60.51.0-0.51.2-0.80.70.2-0.70.7-1.0-0.91.3
Reaction time trials AUC0.20.71.90.51.0-0.51.1-0.80.60.2-0.70.7-1.0-1.01.4
Run reversals in cocaine runway, females0.30.31.1-0.2-0.60.2-0.40.80.0-0.4-0.80.81.00.8-0.2
Run reversals in cocaine runway, males0.91.04.0-0.30.3-0.00.7-0.60.20.6-0.20.2-1.9-2.01.5
Latency to leave start box in cocaine runway1.11.53.01.61.7-1.71.5-1.51.41.3-0.30.3-0.6-0.10.8
Latency to leave start box in cocaine runway, F0.40.51.00.81.0-0.80.8-0.90.60.7-0.20.2-0.8-0.61.0
Latency to leave start box in cocaine runway, M2.32.25.01.92.0-2.22.0-1.81.81.7-0.40.4-0.20.5-0.1
Std. dev. time between licks in bursts0.30.51.7-0.30.20.40.0-0.30.70.60.8-0.8-1.2-1.3-0.2
Total sessions with >9 infusions0.10.20.50.3-0.0-0.00.00.30.00.1-0.60.60.70.60.2
Short access day 1 total inactive lever presses0.40.94.40.2-0.2-0.6-0.70.40.40.00.3-0.32.02.1-0.9
Short access day 10 total inactive lever presses0.10.51.8-0.7-0.8-0.0-1.30.50.10.20.9-0.90.70.7-0.8
Short access day 1 total infusions0.10.30.90.80.5-0.50.4-0.20.50.6-0.10.10.80.9-0.2
Short access day 10 total infusions0.81.33.3-0.4-1.20.7-0.81.5-1.5-1.2-0.80.81.81.40.2
Short access total infusions0.40.61.7-0.2-0.70.5-0.60.9-0.8-0.6-0.80.81.30.80.5
Short access day 1 locomotion0.20.41.00.60.5-0.30.4-0.20.20.51.0-1.00.20.6-0.9
Short access day 10 total locomotion0.10.62.40.50.1-0.7-0.40.10.60.6-0.50.51.51.6-0.1
Short access total locomotion0.40.62.90.2-0.2-0.3-0.60.50.10.10.0-0.01.61.7-1.0
One hour access (0.3 mA shock)0.40.40.80.80.6-0.90.6-0.50.80.7-0.70.70.50.70.4
Compulsive drug intake0.91.44.70.30.4-0.90.1-0.11.20.3-2.22.21.31.01.5
One hour access (shock baseline)0.10.20.80.0-0.30.2-0.10.2-0.50.10.9-0.90.00.2-0.6
Social response proportion1.21.55.71.61.1-1.40.9-0.50.90.2-0.60.61.82.4-1.1
Social responses0.20.32.20.30.10.10.30.20.5-0.10.2-0.20.60.7-1.5
Social time0.30.51.30.90.8-1.10.5-0.60.70.6-0.70.70.30.5-0.2
Soleus weight10.430.856.96.67.5-6.27.4-7.56.57.3-1.11.1-3.9-1.32.2
Bone: stiffness0.61.13.01.11.2-1.11.2-1.10.70.9-1.11.1-0.4-0.21.7
Tibialis anterior weight10.034.560.07.47.7-7.17.5-7.46.86.6-3.63.6-2.4-0.24.0
Time to tail flick, vehicle, before self-admin1.11.44.1-1.6-1.21.5-0.31.2-2.0-1.3-0.20.2-0.6-1.21.2
Time to tail flick, vehicle, after self-admin0.40.92.01.10.8-0.80.5-0.80.70.6-1.41.41.01.10.7
Time to tail flick, test, before self-admin2.02.35.5-1.7-1.21.7-0.81.2-1.4-1.42.3-2.3-0.8-0.7-1.9
Time to tail flick, test, after self-admin1.51.63.4-1.8-1.61.8-1.51.5-0.8-1.00.9-0.9-0.5-1.1-1.0
Delta time to tail flick, vehicle, before/after SA1.11.13.21.51.1-1.20.4-1.51.81.4-0.80.80.00.30.3
Delta time to tail flick, test, before/after SA0.70.92.80.70.2-0.8-0.3-0.31.20.8-1.71.71.00.80.4
Tibia length0.61.65.51.30.6-1.40.1-0.81.41.70.2-0.21.62.3-1.2
Ambulatory time before self-admin0.10.41.3-0.10.3-0.50.2-0.60.80.50.5-0.5-1.1-1.10.6
Ambulatory time after self-admin1.62.54.52.11.7-2.01.6-1.72.12.0-1.11.10.61.11.2
Bone: tissue strength0.60.61.5-0.1-0.70.3-0.70.8-1.0-1.0-0.70.71.20.90.8
Total heroin consumption0.91.12.00.51.1-0.61.4-1.20.91.2-0.80.8-1.1-1.01.4
Bone: trabecular number1.01.94.6-1.7-1.32.1-1.11.2-1.5-1.21.5-1.5-0.9-1.4-0.3
Bone: trabecular spacing0.10.21.0-0.3-0.40.1-0.30.4-1.0-0.70.2-0.20.20.2-0.5
Bone: trabecular thickness0.30.42.00.0-0.40.2-0.60.6-0.4-0.4-0.20.21.41.4-0.4
Bone: trabecular tissue density3.15.512.63.32.8-3.52.3-2.42.02.0-1.91.91.32.50.4
Water consumed over 24 hours0.10.30.6-0.3-0.60.2-0.80.20.10.5-0.70.70.70.40.3
Number of responses in last shaping day0.20.31.00.50.1-0.20.0-0.00.61.00.3-0.30.60.9-0.6