Hub : Genes

Unc13c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Unc13c 0.09 0.05 1.2e-04 0.08 0.05 0.04 -0 3.9e-04 3.7e-03 8.6e-03 3.4e-01
2 NAcc mRNA stability Unc13c 0.03 0.02 1.5e-06 0.04 0.04 0.04 0.04 2.1e-06 3.1e-06 8.9e-07 1.4e-06
3 PL gene expression Unc13c 0.03 0.02 1.1e-03 0.03 0.02 0.02 0.03 8.9e-04 2.1e-03 6.0e-03 6.1e-04
4 OFC isoform ratio NM_173146.2 0.18 0.11 3.8e-03 0.08 0.07 0.05 0.06 5.5e-03 7.9e-03 3.0e-02 1.2e-02
5 NAcc gene expression Unc13c 0.09 0.04 0.0e+00 0.16 0.15 0.13 0.16 9.8e-23 1.4e-22 4.5e-19 5.3e-23
6 BLA mRNA stability Unc13c 0.1 0.07 1.1e-03 0.1 0.06 0.08 0.08 6.1e-06 4.0e-04 3.8e-05 4.1e-05
7 OFC gene expression Unc13c 0.21 0.11 9.2e-04 0.1 0.12 0.13 0.13 1.9e-03 7.6e-04 5.6e-04 5.7e-04
8 Brain alternative polyA NM_173146.2 0.04 0.03 4.9e-04 0.03 0.03 0.03 0.03 1.7e-03 7.9e-04 8.0e-04 5.2e-04
9 Brain alternative polyA XM_063264996.1 0.04 0.03 5.1e-04 0.03 0.03 0.03 0.03 9.8e-04 6.6e-04 7.3e-04 5.0e-04
10 Brain gene expression Unc13c 0.18 0.07 8.3e-15 0.12 0.17 0.14 0.17 1.4e-11 5.8e-16 1.1e-12 3.0e-15
11 Brain mRNA stability Unc13c 0.15 0.07 3.3e-07 0.06 0.08 0.06 0.06 1.7e-06 1.1e-07 6.0e-06 1.8e-06
12 pVTA mRNA stability Unc13c 0.05 0.04 4.7e-03 0.02 0.01 -0 0.01 1.3e-02 2.6e-02 8.8e-01 6.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.40.61.70.90.71.30.60.71.10.80.8-0.8-0.3-0.50.0
Area under the delay curve0.20.20.6-0.3-0.10.2-0.2-0.5-0.2-0.60.6-0.6-0.8-0.60.4
BMI with tail3.712.726.5-4.7-5.0-4.3-5.2-5.0-3.2-4.5-0.50.5-1.80.4-0.3
BMI without tail1.13.58.7-1.7-2.3-1.1-2.9-2.4-0.5-2.01.7-1.7-2.4-1.10.9
Body weight1.77.614.7-3.5-3.8-3.2-3.6-3.8-2.6-3.71.3-1.3-1.40.71.0
Weight adjusted by age2.74.07.2-2.3-2.6-2.2-2.4-2.7-2.6-2.7-1.41.4-0.7-0.0-0.6
Bone surface0.30.62.4-0.0-0.40.2-0.6-0.6-0.2-0.8-0.70.7-1.1-1.3-1.5
Bone volume0.10.20.90.0-0.30.3-0.4-0.30.3-0.4-0.00.0-0.8-0.8-0.9
Breakpoint value in progressive ratio session0.20.20.6-0.1-0.4-0.4-0.7-0.6-0.4-0.50.3-0.3-0.8-0.7-0.3
Number of licking bursts0.91.43.51.91.61.71.81.10.40.4-0.60.6-0.2-1.3-0.7
Context. condit. distance diff. score0.20.20.70.00.40.50.50.5-0.00.40.0-0.00.90.8-0.2
Locomotion velocity, session 10.30.40.8-0.4-0.6-0.5-0.8-0.6-0.1-0.6-0.30.3-0.9-0.7-0.8
Locomotion distance, session 10.91.12.71.30.91.40.50.81.40.90.7-0.7-1.3-1.6-0.0
Locomotion velocity, session 20.40.42.10.20.00.3-0.5-0.20.1-0.00.4-0.4-1.4-1.4-0.6
Locomotion distance, session 21.01.46.20.5-0.30.6-0.9-0.50.3-0.11.1-1.1-2.5-2.4-0.2
Locomotion velocity, session 30.60.73.90.80.00.4-0.2-0.0-0.1-0.10.1-0.1-1.6-2.0-1.2
Locomotion distance, session 32.02.25.32.31.71.81.51.61.71.31.1-1.1-0.9-1.60.0
Stereotopy head waving bouts, day 31.41.73.2-1.7-1.1-1.4-0.7-0.8-1.1-0.5-1.81.81.51.7-0.4
Stereotopy head waving duration, day 31.92.34.7-2.0-1.2-1.4-0.9-1.0-1.2-0.3-2.22.21.72.1-0.8
Locomotion velocity, session 70.40.41.20.70.71.00.50.70.81.10.4-0.4-0.2-0.5-0.2
Locomotion distance, session 70.81.12.31.41.11.50.80.81.20.80.8-0.8-0.9-1.4-0.3
Stereotopy head waving bouts, day 70.80.92.7-0.7-0.8-0.8-0.9-0.7-0.7-0.3-1.41.4-0.4-0.5-1.6
Stereotopy head waving duration, day 71.21.44.5-0.8-1.0-0.7-1.1-0.9-1.0-0.3-1.81.8-0.7-0.9-2.1
Locomotion velocity, session 80.91.13.6-0.2-0.60.1-1.0-0.7-0.9-0.4-0.70.7-1.6-1.9-1.8
Locomotion distance, session 80.71.03.81.00.61.40.10.30.30.40.7-0.7-1.6-1.9-0.8
Degree of sensitization distance0.10.10.3-0.20.20.40.1-0.0-0.10.2-0.50.50.30.1-0.2
Degree of sensitization stereotypy0.50.62.0-0.4-0.6-0.6-0.7-0.5-0.6-0.3-0.90.9-0.7-0.8-1.4
Conditioned locomotion0.91.04.30.20.10.20.20.2-0.00.12.1-2.10.10.61.9
Cocaine response after cond. corrected4.04.87.7-2.8-2.3-2.2-2.0-2.4-2.4-2.3-2.42.40.51.1-2.3
Cocaine response after cond. not corrected3.54.16.7-2.6-2.0-2.2-1.6-2.1-2.3-2.3-2.32.31.01.7-1.5
Cocaine response before conditioning0.70.84.30.70.80.40.80.50.1-0.21.3-1.30.10.12.1
Saline control response0.20.31.0-0.10.1-0.10.30.30.10.2-1.01.00.80.5-0.5
Bone: connectivity density1.52.46.42.01.62.51.31.62.01.61.0-1.0-0.8-1.60.0
Bone: cortical apparent density1.31.73.11.01.41.21.61.71.71.8-0.60.61.71.1-0.1
Bone: cortical area0.81.25.6-0.60.1-0.60.60.30.30.1-1.21.22.32.4-0.0
Bone: cortical porosity1.31.54.30.71.00.71.11.00.40.51.9-1.90.81.02.1
Bone: cortical porosity1.41.54.20.71.00.81.01.00.50.61.9-1.90.81.02.0
Bone: cortical thickness2.23.610.00.81.81.12.12.22.32.2-0.60.63.22.70.6
Bone: cortical thickness0.70.93.9-0.00.50.00.90.70.20.4-0.40.42.02.00.7
Bone: cortical tissue density1.21.63.01.01.41.21.51.61.71.7-0.60.61.50.9-0.1
Condit. Reinf. active minus inactive responses1.41.64.71.10.40.8-0.10.20.20.32.2-2.2-2.0-1.80.5
Condit. Reinf. active-inactive response ratio0.20.20.8-0.20.1-0.40.10.1-0.70.10.2-0.20.70.90.1
Condit. Reinf. active responses2.22.89.61.20.31.0-0.50.00.60.22.3-2.3-3.1-3.1-0.1
Condit. Reinf. inactive responses2.42.913.51.30.31.3-0.50.11.30.21.6-1.6-3.3-3.7-0.4
Incentive salience index mean1.51.86.10.70.10.4-0.4-0.2-0.4-0.42.5-2.5-2.1-1.81.1
Condit. Reinf. lever presses1.21.75.70.3-0.10.2-0.4-0.4-0.5-0.92.4-2.4-1.7-1.41.8
Condit. Reinf. active minus inactive responses1.21.53.0-1.2-1.3-1.1-1.3-1.3-1.0-0.9-1.71.7-0.4-0.2-1.7
Condit. Reinf. active-inactive response ratio1.41.64.5-1.4-1.1-1.0-0.9-0.9-0.7-0.4-2.12.10.80.9-1.6
Condit. Reinf. active responses0.30.51.0-0.5-1.0-0.5-0.9-1.0-0.8-0.90.0-0.0-0.9-0.5-0.2
Condit. Reinf. inactive responses1.31.75.21.40.71.00.50.50.30.02.3-2.3-1.3-1.31.7
Condit. Reinf. lever presses0.50.72.70.40.80.31.30.7-0.70.3-0.70.71.61.30.1
Condit. Reinf. lever reinforcers received0.20.20.5-0.3-0.7-0.4-0.6-0.7-0.6-0.70.1-0.1-0.6-0.3-0.0
Conditioned reinforcement - actives0.30.41.0-1.0-0.8-0.6-0.9-0.7-1.0-0.7-0.20.20.20.50.0
Conditioned reinforcement - inactives0.10.20.5-0.2-0.1-0.6-0.10.0-0.7-0.40.0-0.00.60.7-0.1
Conditioned locomotion0.50.62.5-0.10.1-0.0-0.00.40.40.21.3-1.30.61.01.6
Patch foraging indifference point 0 sec0.40.82.5-0.3-0.6-0.4-0.6-0.5-0.8-0.7-1.41.4-0.4-0.6-1.6
Patch foraging indifference point AUC1.72.47.31.30.71.40.30.50.50.22.7-2.7-1.8-1.71.8
Delay disc. indifference point, 0s delay2.02.26.61.51.01.80.60.61.40.71.5-1.5-2.2-2.6-0.5
Delay disc. indifference point, 16s delay0.30.41.20.10.50.60.50.60.40.60.4-0.40.80.81.1
Delay disc. indifference point, 2s delay0.10.10.40.30.20.50.2-0.00.1-0.10.4-0.4-0.5-0.6-0.1
Delay disc. indifference point, 24s delay0.60.71.70.50.70.80.90.70.80.51.3-1.30.20.21.1
Delay disc. indifference point, 4s delay0.20.20.40.10.30.30.1-0.10.1-0.40.7-0.7-0.6-0.6-0.3
Delay disc. indifference point, 8s delay1.01.22.9-0.8-0.9-0.6-1.0-1.4-1.3-1.70.4-0.4-1.6-1.20.3
Indifference point function ln k1.83.15.8-2.1-1.6-2.2-1.1-1.3-1.5-1.1-2.42.41.21.4-2.1
Indifference point function log k1.83.15.8-2.1-1.6-2.2-1.1-1.3-1.5-1.1-2.42.41.21.4-2.1
Patch foraging total patch changes 0 sec0.40.71.9-0.3-0.6-0.4-0.6-0.5-0.8-0.7-1.41.4-0.2-0.4-1.4
Patch foraging total patch changes 12 sec0.71.01.81.30.81.20.81.00.40.51.4-1.4-0.5-0.91.0
Patch foraging total patch changes 18 sec0.20.20.80.70.60.90.60.70.20.3-0.20.20.4-0.1-0.0
Patch foraging total patch changes 24 sec0.71.24.71.20.51.30.30.21.30.10.6-0.6-1.8-2.2-0.8
Patch foraging total patch changes 6 sec0.81.36.01.00.20.9-0.30.10.80.30.5-0.5-2.1-2.5-1.1
Patch foraging time to switch 0 sec0.30.61.10.50.80.51.00.80.71.1-0.80.81.00.5-0.5
Patch foraging water rate 0 sec0.81.83.9-1.6-1.6-1.6-1.8-1.6-1.6-2.0-0.50.5-0.40.1-0.8
Patch foraging water rate 12 sec1.02.13.9-1.5-1.8-1.6-1.5-1.7-1.4-1.5-1.41.4-0.7-0.4-2.0
Patch foraging water rate 18 sec0.10.11.0-0.1-0.1-0.1-0.30.01.00.40.1-0.1-0.00.20.1
Patch foraging water rate 24 sec0.40.61.40.80.80.60.20.81.10.6-0.70.7-0.4-0.9-1.2
Patch foraging water rate 6 sec0.30.40.8-0.5-0.7-0.4-0.8-0.6-0.8-0.9-0.10.1-0.7-0.7-0.9
Seeking ratio, delayed vs. immediate footshock2.93.66.7-2.1-2.4-1.8-2.6-2.4-1.9-2.5-0.80.8-1.6-1.0-1.3
Distance traveled before self-admin0.70.91.9-0.6-0.9-1.2-0.8-1.2-1.4-1.0-0.40.4-1.0-0.9-1.3
Distance traveled after self-admin2.53.15.2-2.3-1.9-2.2-1.7-2.1-2.2-2.3-1.31.30.10.6-1.5
Extensor digitorum longus weight4.517.837.2-5.2-5.9-5.2-6.1-5.6-4.1-5.0-0.40.4-3.0-0.8-1.6
Bone: elastic displacement0.20.31.1-0.0-0.00.3-0.2-0.00.70.30.9-0.9-0.30.11.0
Bone: elastic work0.20.30.9-0.20.10.10.10.20.10.30.9-0.90.60.90.8
Bone: endosteal estimation2.86.212.3-2.8-3.0-3.0-2.9-3.2-3.5-3.5-1.21.2-1.1-0.2-1.2
Bone: endosteal perimeter1.83.87.3-2.2-2.6-2.4-2.4-2.6-2.7-2.7-0.40.4-1.0-0.1-0.4
Epididymis fat weight0.41.53.41.00.61.30.20.71.11.21.8-1.8-1.2-1.11.4
Delta time in closed arm before/after self-admin1.31.22.80.90.60.21.21.00.40.81.4-1.41.21.31.7
Delta time in open arm before/after self-admin1.71.76.40.41.00.60.70.90.80.9-2.22.20.7-0.2-2.5
Diff in mean of infusions in LGA sessions1.62.04.3-1.8-1.7-2.1-2.0-1.7-1.8-1.60.0-0.0-0.30.60.6
Delay discount exponential model param0.20.20.60.30.1-0.10.20.50.30.7-0.60.60.80.6-0.3
Extinction: sum of active levers before priming0.00.10.10.30.1-0.0-0.00.2-0.30.1-0.30.30.30.1-0.3
Active lever presses in extinction session 61.21.23.1-0.8-1.1-0.9-1.8-1.3-1.2-1.1-0.70.7-1.0-0.8-1.4
Bone: final force0.40.61.4-1.1-0.7-1.0-0.7-0.8-0.7-0.8-0.20.20.71.2-0.1
Bone: final moment0.40.63.0-1.1-0.5-0.9-0.4-0.5-0.5-0.4-0.20.21.21.70.1
Food consumed during 24 hour testing period2.33.25.8-1.8-1.4-2.0-0.9-1.6-2.4-2.2-2.32.31.21.4-1.0
Glucose0.40.61.3-0.8-1.0-0.6-1.0-0.8-0.5-0.4-0.90.9-0.5-0.4-1.2
Heart weight0.50.83.00.3-0.10.8-0.5-0.30.6-0.11.1-1.1-1.7-1.5-0.4
Delay discount hyperbolic model param0.20.20.50.20.1-0.10.20.50.30.7-0.70.70.70.5-0.4
Intermittent access intake day 1-15 change0.30.51.3-0.3-0.4-0.1-0.3-0.9-1.0-1.0-0.10.1-1.1-1.0-0.7
Intermittent access intake escalation0.20.51.3-0.3-0.4-0.1-0.3-0.9-0.9-1.0-0.10.1-1.1-1.1-0.8
Intermittent access intake escalation 21.21.43.0-0.8-1.1-0.9-0.8-1.6-1.7-1.7-0.50.5-1.3-1.1-1.3
Intermitt. access day 1 inactive lever presses0.31.25.40.51.00.21.31.30.40.6-0.10.12.32.00.4
Intermitt. access day 15 inactive lever presses0.20.30.70.40.50.40.80.30.40.10.7-0.70.60.60.7
Intermitt. access escalation Index0.20.20.8-0.3-0.6-0.6-0.6-0.5-0.9-0.6-0.30.3-0.20.10.2
Intermittent access day 1 total infusions0.50.72.20.51.00.40.81.11.10.7-0.20.21.51.20.1
Intermittent access day 15 total infusions0.00.10.20.20.50.30.40.30.40.20.1-0.10.20.20.1
Intermittent access terminal intake (last 3 days)0.10.10.5-0.5-0.1-0.40.0-0.2-0.2-0.50.1-0.10.50.70.3
Intermittent access total infusions0.40.42.0-0.20.5-0.10.40.50.30.0-0.50.51.41.3-0.0
Intermittent access day 1 locomotion0.70.93.10.20.6-0.00.80.80.90.30.9-0.91.61.81.3
Intermittent access day 15 total locomotion0.30.52.7-0.40.0-0.40.20.10.1-0.30.3-0.31.31.60.8
Intermittent access total locomotion0.50.52.2-0.8-0.4-1.0-0.4-0.3-0.3-0.9-0.30.31.11.50.2
Intermittent access standard deviation0.10.20.9-0.5-0.2-0.40.1-0.4-0.6-0.90.2-0.20.20.30.4
Left kidney weight0.63.05.6-2.3-2.3-2.1-2.2-2.2-1.8-2.40.2-0.20.31.50.4
Right kidney weight0.52.14.9-1.6-2.1-1.5-2.2-2.0-1.5-2.00.3-0.3-1.0-0.0-0.1
Cocaine induced anxiety0.20.31.00.20.40.40.10.40.80.20.8-0.80.40.51.0
Post-drug Anxiety0.80.92.21.11.21.30.80.91.50.90.7-0.7-0.2-0.60.3
Baseline Anxiety0.70.82.91.00.80.90.50.40.60.9-0.50.5-1.1-1.7-1.0
Tail length0.93.46.22.21.72.41.51.42.21.32.5-2.5-1.0-1.31.3
Length with tail0.10.62.60.40.00.40.2-0.30.6-0.21.6-1.6-1.0-0.70.5
Length without tail1.54.79.5-2.8-2.8-3.0-2.0-3.0-2.9-3.1-0.50.5-0.30.9-0.7
Times rat made contact with spout0.40.41.00.50.90.51.00.60.60.1-0.50.51.00.7-0.5
Lifetime Intake0.30.31.6-0.10.40.00.20.60.40.1-0.50.51.31.1-0.1
Liver weight, left1.11.93.8-1.3-2.0-1.6-1.6-1.9-1.5-1.9-0.90.9-0.9-0.3-0.4
Liver weight, right0.81.53.0-1.6-1.6-1.4-1.7-1.6-1.1-1.6-0.60.6-0.60.1-0.1
Locomotor activity1.82.96.6-2.4-2.6-1.8-2.3-2.3-1.9-1.9-0.10.1-0.11.00.6
Locomotor testing distance0.91.74.1-2.0-2.0-1.2-1.8-1.6-1.3-1.0-0.60.60.31.0-0.1
Locomotor testing rearing0.20.41.3-1.1-1.1-0.5-1.1-0.6-0.2-0.30.2-0.20.00.4-0.5
Locomotion in novel chamber0.30.41.5-0.10.50.40.60.50.10.50.2-0.21.21.20.0
Locomotion in novel chamber post-restriction0.20.41.50.80.70.70.80.51.20.40.1-0.1-0.3-0.60.1
Fecal boli incidents, locomotor time 10.60.92.61.00.50.60.70.2-0.8-0.41.6-1.6-0.8-0.81.2
Change in fecal boli incidents, locomotor task3.63.511.0-1.8-1.2-1.7-1.3-1.0-1.1-0.9-3.33.31.11.0-2.4
Time >=10cm from walls, locomotor time 10.40.40.8-0.6-0.6-0.6-0.9-0.8-0.5-0.6-0.80.8-0.5-0.4-0.2
Bouts of movement, locomotor time 10.30.40.9-0.7-0.6-0.6-0.4-0.7-0.6-0.90.6-0.6-0.5-0.10.7
Total resting periods, locomotor time 10.20.20.7-0.6-0.4-0.6-0.2-0.4-0.6-0.90.3-0.3-0.10.20.5
Rest time, locomotor task time 10.40.62.3-0.10.40.10.70.6-0.5-0.10.7-0.71.31.50.7
Distance moved, locomotor task time 10.60.93.50.70.31.0-0.20.11.40.9-0.40.4-1.5-1.9-0.5
Vertical activity count, locomotor time 10.20.62.20.50.20.6-0.30.11.50.7-0.20.2-1.2-1.4-0.2
Time >=10cm from walls, locomotor time 20.20.21.9-0.00.10.1-0.10.00.2-0.10.5-0.50.40.61.4
Bouts of movement, locomotor time 20.40.61.8-0.3-0.50.7-1.0-0.40.80.11.0-1.0-1.4-1.00.4
Total resting periods, locomotor time 20.20.41.1-0.4-0.50.5-1.0-0.40.70.00.5-0.5-1.0-0.80.2
Rest time, locomotor task time 20.70.93.60.10.70.40.71.20.31.0-0.60.61.91.60.4
Distance moved, locomotor task time 20.80.95.20.60.00.6-0.4-0.30.50.1-0.10.1-2.0-2.3-0.8
Vertical activity count, locomotor time 20.50.72.31.20.81.10.60.40.90.50.0-0.0-1.0-1.5-0.0
Light reinforcement 11.22.95.4-1.3-2.2-1.3-2.3-2.3-1.6-2.21.2-1.2-2.1-1.10.3
Light reinforcement 20.60.84.2-0.20.4-0.10.70.5-0.30.40.1-0.11.92.01.0
Bone: marrow area2.96.312.8-2.8-3.1-3.0-2.9-3.2-3.6-3.5-1.31.2-1.0-0.0-1.2
Bone: maximum diameter1.42.76.0-1.9-1.9-2.1-1.5-2.0-1.6-2.4-1.31.30.20.9-1.2
Bone: maximum force0.40.71.5-1.2-0.9-1.2-0.9-0.9-0.7-1.0-0.40.40.51.0-0.2
Bone: maximum moment0.40.72.3-1.2-0.6-1.0-0.6-0.6-0.5-0.7-0.40.41.01.50.1
Mean time between licks in bursts0.20.51.00.70.80.81.01.00.30.70.2-0.20.80.30.5
Mean num. licks in bursts0.81.24.2-1.7-1.2-1.5-1.2-0.8-0.1-0.50.2-0.21.12.00.3
Cd content in liver3.53.97.02.41.72.41.11.42.71.62.4-2.4-1.8-2.20.5
Co content in liver1.92.24.81.51.41.61.31.31.71.02.2-2.20.10.01.7
Cu content in liver0.30.40.8-0.6-0.5-0.7-0.3-0.6-0.2-0.90.7-0.70.30.80.6
Fe content in liver0.50.63.2-0.1-0.30.1-0.4-0.40.3-0.4-0.70.7-0.9-1.1-1.8
K content in liver0.10.10.2-0.1-0.2-0.2-0.1-0.30.4-0.50.2-0.2-0.20.1-0.1
Mg content in liver0.40.41.1-0.6-0.8-0.9-0.6-0.8-0.3-1.10.0-0.0-0.30.0-0.4
Mn content in liver1.41.67.8-0.50.2-0.40.80.6-0.60.30.0-0.12.42.81.7
Na content in liver2.42.64.9-1.7-2.2-1.6-2.1-2.2-1.8-2.20.2-0.2-1.6-0.7-0.5
Rb content in liver0.60.71.9-0.8-1.0-0.7-0.9-1.0-0.4-0.9-0.50.5-0.6-0.4-1.4
Se content in liver0.50.61.20.70.80.51.10.91.10.8-0.80.80.90.4-0.8
Sr content in liver1.21.11.91.41.11.31.01.00.51.11.1-1.1-0.5-0.91.0
Zn content in liver0.40.41.4-0.10.0-0.10.10.10.60.21.2-1.20.40.70.9
Bone: minimum diameter0.40.73.7-0.6-0.1-0.70.2-0.0-0.2-0.50.4-0.41.41.91.1
Time in familiar zone, hab. session 10.10.10.30.20.00.00.1-0.1-0.4-0.60.4-0.4-0.3-0.20.4
Time in novel zone, hab. session 10.30.30.80.10.30.10.40.60.30.9-0.60.60.80.5-0.4
Total zone transitions, hab. session 12.02.85.22.11.32.30.81.32.01.71.5-1.5-1.7-2.20.3
Total locomotion distance, hab. session 11.21.63.81.50.81.70.30.91.81.40.9-0.9-1.6-1.9-0.5
Locomotion velocity, hab. session 10.60.92.70.90.41.1-0.10.41.10.80.8-0.8-1.4-1.6-0.4
Time in familiar zone, hab. session 20.10.10.40.50.60.40.60.50.20.1-0.30.30.1-0.3-0.1
Time in novel zone, hab. session 20.60.61.2-1.0-0.7-0.9-0.5-0.6-0.8-0.4-0.80.80.81.1-0.3
Total zone transitions, hab. session 22.32.98.31.50.41.9-0.30.31.50.82.1-2.1-2.9-2.90.6
Total locomotion distance, hab. session 22.12.86.51.30.31.8-0.20.41.30.72.5-2.5-2.5-2.40.8
Locomotion velocity, hab. session 21.92.67.11.30.31.6-0.20.41.20.72.7-2.7-2.2-2.11.1
Novel to familiar place preference ratio1.21.32.4-1.3-1.5-1.5-1.4-1.5-1.4-1.40.4-0.4-0.40.40.6
Novelty place preference1.51.62.9-1.5-1.7-1.7-1.5-1.7-1.7-1.70.2-0.2-0.30.60.6
Time in novel zone, NPP test1.92.03.8-1.8-1.8-1.9-1.6-1.8-1.9-1.8-0.50.50.00.90.1
Total zone transitions, NPP test0.91.34.11.10.51.6-0.10.31.20.71.1-1.1-1.9-2.0-0.1
Total locomotion distance, NPP test1.21.66.01.10.31.5-0.30.20.90.51.3-1.3-2.3-2.4-0.2
Locomotion velocity, NPP test1.82.68.01.60.61.90.00.61.20.91.8-1.8-2.6-2.80.1
Intraocular pressure0.20.30.90.60.50.60.40.80.80.9-0.30.3-0.0-0.3-0.1
Delta distance traveled before/after self-admin2.12.35.5-2.3-1.7-1.7-1.3-1.4-1.7-1.7-0.90.91.21.8-0.0
Delta ambulatory time before/after self-admin1.61.94.6-2.0-1.2-1.3-0.9-0.9-1.4-1.3-1.31.31.72.1-0.2
Parametrial fat weight2.35.511.02.92.72.72.62.63.32.52.0-2.00.1-0.51.6
Pavlov. Cond. lever latency1.51.95.3-0.7-0.0-0.50.40.3-0.00.6-2.32.32.32.1-1.3
Pavlov. Cond. magazine entry latency4.96.321.42.01.61.81.01.41.20.84.6-4.6-1.4-1.23.9
Pavlov. Cond. change in total contacts2.52.710.40.60.20.5-0.20.2-0.2-0.13.2-3.2-1.4-0.92.8
Pavlov. Cond. index score3.94.916.31.71.11.50.50.80.90.34.0-4.0-2.1-1.93.1
Pavlov. Cond. latency score3.44.313.91.61.01.50.50.80.90.33.7-3.7-2.1-1.92.8
Pavlov. Cond. lever contacts1.92.37.70.70.20.5-0.2-0.1-0.1-0.52.8-2.8-1.9-1.62.1
Pavlov. Cond. magazine entry number4.25.317.1-1.9-1.5-1.6-1.0-1.3-1.3-0.8-4.14.11.41.2-3.5
Pavlov. Cond. intertrial magazine entries1.21.56.50.4-0.10.4-0.5-0.30.80.1-1.21.2-1.5-2.0-2.6
Pavlov. Cond. lever-magazine prob. diff.3.84.716.21.50.91.40.30.60.70.04.0-4.0-2.3-2.03.1
Pavlov. Cond. response bias3.44.215.01.40.91.00.30.60.70.13.9-3.9-1.9-1.53.2
Pavlov. Cond. lever latency0.30.41.0-1.0-0.8-0.5-1.0-0.50.10.1-0.70.70.10.3-0.3
Pavlov. Cond. magazine entry latency3.84.69.92.62.92.23.12.81.92.61.0-1.01.50.71.3
Pavlov. Cond. change in total contacts0.91.53.51.71.71.21.91.51.51.10.7-0.70.4-0.00.4
Pavlov. Cond. index score1.31.74.71.91.91.42.21.60.91.20.7-0.70.6-0.00.7
Pavlov. Cond. latency score0.91.24.01.61.61.12.01.40.61.00.3-0.30.70.20.4
Pavlov. Cond. lever contacts0.20.31.00.90.70.51.00.4-0.2-0.20.6-0.6-0.0-0.20.4
Pavlov. Cond. magazine entry number2.63.27.6-2.3-2.6-2.0-2.7-2.3-1.7-2.1-0.40.3-1.1-0.2-0.4
Pavlov. Cond. intertrial magazine entries0.81.22.6-0.9-1.4-1.0-1.4-1.4-1.0-1.6-0.50.5-1.3-1.0-0.4
Pavlov. Cond. lever-magazine prob. diff.1.62.15.52.12.01.52.41.81.11.30.9-0.90.6-0.10.9
Pavlov. Cond. response bias1.62.14.12.01.91.52.01.61.11.21.6-1.60.2-0.31.0
Time in closed arm before self-admin0.10.10.2-0.1-0.00.5-0.1-0.30.1-0.10.2-0.2-0.5-0.40.5
Time in closed arm after self-admin0.91.03.30.80.40.70.50.60.61.01.5-1.50.20.31.8
Time in open arm before self-admin1.21.33.3-1.2-1.3-1.7-0.7-1.1-1.8-1.5-0.20.20.51.20.1
Time in open arm after self-admin1.31.43.8-1.0-0.4-1.2-0.5-0.4-1.1-0.9-1.91.91.00.9-1.7
Bone: periosteal estimation1.63.36.1-2.2-2.1-2.3-1.8-2.1-2.2-2.5-1.41.40.41.1-0.9
Bone: periosteal perimeter1.32.34.1-1.9-1.8-2.0-1.5-1.7-1.7-1.9-1.21.20.51.2-0.8
Bone: post-yield work0.50.71.8-0.3-0.7-0.1-0.6-0.9-1.1-1.3-0.50.5-1.0-1.1-0.8
Progressive ratio test 1 active lever presses0.20.31.0-0.10.30.3-0.00.50.30.3-0.70.71.00.90.1
Progressive ratio test 1 breakpoint0.20.31.1-0.10.30.20.10.60.20.2-0.70.71.00.90.2
Progressive ratio test 1 inactive lever presses0.71.03.20.71.20.61.01.40.70.6-0.60.61.81.2-0.5
Progressive ratio test 2 active lever presses0.60.71.8-1.2-1.0-1.0-1.3-0.8-0.9-0.7-0.60.60.00.4-0.1
Progressive ratio test 2 breakpoint0.50.51.5-1.1-0.9-0.8-1.2-0.6-0.8-0.6-0.60.6-0.00.3-0.1
Progressive ratio test 2 inactive lever presses0.30.42.3-0.20.3-0.10.40.4-0.10.1-0.50.51.51.4-0.1
Incentive Sensitization - Responses1.11.53.7-1.4-1.6-1.5-1.9-1.5-1.6-1.3-0.10.1-1.0-0.30.4
Incentive Sensitization - Breakpoint1.01.33.3-1.2-1.5-1.3-1.8-1.3-1.3-1.10.1-0.1-1.2-0.50.5
Sum of active levers in priming session hrs 5-60.90.82.8-0.9-0.7-0.8-0.6-0.7-0.9-0.6-1.21.20.10.0-1.7
Progressive ratio0.61.03.70.0-0.10.0-0.2-0.1-0.4-0.41.9-1.9-0.7-0.21.9
Food seeking constrained by brief footshock1.11.34.4-0.3-0.40.3-0.7-0.8-0.5-1.0-1.61.6-1.2-1.4-2.1
Seeking ratio, punishment vs. effort1.82.69.4-1.1-1.3-0.9-1.4-1.3-0.5-1.0-2.42.4-0.6-0.7-3.1
Retroperitoneal fat weight1.14.710.02.72.32.92.12.23.22.42.0-1.9-0.5-1.01.1
Reaction time number correct0.40.71.5-0.6-1.0-0.5-1.2-0.8-0.7-0.3-0.60.6-1.0-0.9-1.2
Reaction time mean minus median0.20.41.00.40.60.40.50.61.00.60.2-0.20.60.61.0
Reaction time mean minus median AUC0.30.71.50.71.10.71.01.11.21.0-0.10.10.90.70.6
Reaction time num false alarms0.40.61.80.70.61.10.50.71.41.3-0.20.20.2-0.2-0.7
Reaction time num false alarms AUC0.30.40.90.50.40.80.30.50.90.9-0.60.60.1-0.2-0.9
Reaction time trials correct on left0.40.71.5-0.6-1.0-0.5-1.2-0.8-0.7-0.3-0.60.6-1.0-0.9-1.2
Reaction time trials on left0.40.71.6-0.5-1.0-0.5-1.2-0.8-0.7-0.2-0.70.7-1.0-0.9-1.3
Reaction time mean1.21.83.21.11.71.11.81.61.81.50.3-0.31.61.31.0
Reaction time mean AUC0.81.22.81.01.40.91.41.31.71.20.2-0.21.21.00.7
Median of all reaction times1.72.44.21.42.01.32.01.91.91.70.4-0.41.81.41.0
Reaction time omissions0.20.21.00.60.20.30.20.40.81.0-0.30.3-0.2-0.50.1
Reaction time false alarm rate0.50.81.90.91.01.11.01.01.41.2-0.10.10.70.2-0.2
Reaction time premature initiation rate0.20.21.0-0.6-0.5-0.2-0.8-0.31.0-0.10.4-0.40.00.40.3
Reaction time premature initiations0.20.41.7-1.0-1.0-0.6-1.3-0.70.5-0.20.1-0.1-0.40.0-0.3
Std. dev. reaction times0.81.43.51.21.51.01.51.51.91.40.4-0.41.00.70.9
Reaction time trials completed0.40.71.6-0.5-1.0-0.5-1.2-0.8-0.7-0.2-0.70.7-1.0-0.9-1.3
Reaction time trials AUC0.40.71.9-0.5-1.0-0.5-1.1-0.8-0.6-0.2-0.70.7-1.0-1.0-1.4
Run reversals in cocaine runway, females0.30.31.10.20.60.20.40.8-0.00.4-0.80.81.00.80.2
Run reversals in cocaine runway, males0.91.04.00.3-0.3-0.0-0.7-0.6-0.2-0.6-0.20.2-1.9-2.0-1.5
Latency to leave start box in cocaine runway1.31.53.0-1.6-1.7-1.7-1.5-1.5-1.4-1.3-0.30.3-0.6-0.1-0.8
Latency to leave start box in cocaine runway, F0.50.51.0-0.8-1.0-0.8-0.8-0.9-0.6-0.7-0.20.2-0.8-0.6-1.0
Latency to leave start box in cocaine runway, M2.42.25.0-1.9-2.0-2.2-2.0-1.8-1.8-1.7-0.40.4-0.20.50.1
Std. dev. time between licks in bursts0.40.51.70.3-0.20.4-0.0-0.3-0.7-0.60.8-0.8-1.2-1.30.2
Total sessions with >9 infusions0.10.20.5-0.30.0-0.0-0.00.3-0.0-0.1-0.60.60.70.6-0.2
Short access day 1 total inactive lever presses0.70.94.4-0.20.2-0.60.70.4-0.4-0.00.3-0.32.02.10.9
Short access day 10 total inactive lever presses0.20.51.80.70.8-0.01.30.5-0.1-0.20.9-0.90.70.70.8
Short access day 1 total infusions0.20.30.9-0.8-0.5-0.5-0.4-0.2-0.5-0.6-0.10.10.80.90.2
Short access day 10 total infusions1.01.33.30.41.20.70.81.51.51.2-0.80.81.81.4-0.2
Short access total infusions0.50.61.70.20.70.50.60.90.80.6-0.80.81.30.8-0.5
Short access day 1 locomotion0.30.41.0-0.6-0.5-0.3-0.4-0.2-0.2-0.51.0-1.00.20.60.9
Short access day 10 total locomotion0.30.62.4-0.5-0.1-0.70.40.1-0.6-0.6-0.50.51.51.60.1
Short access total locomotion0.50.62.9-0.20.2-0.30.60.5-0.1-0.10.0-0.01.61.71.0
One hour access (0.3 mA shock)0.40.40.8-0.8-0.6-0.9-0.6-0.4-0.8-0.7-0.70.70.50.7-0.4
Compulsive drug intake1.21.44.7-0.3-0.4-0.9-0.1-0.1-1.2-0.3-2.22.21.31.0-1.5
One hour access (shock baseline)0.10.20.8-0.00.30.20.10.20.5-0.10.9-0.90.00.20.6
Social response proportion1.41.55.7-1.6-1.1-1.4-0.9-0.5-0.9-0.2-0.60.61.82.41.1
Social responses0.20.32.2-0.3-0.10.1-0.30.2-0.50.10.2-0.20.60.71.5
Social time0.40.51.3-0.9-0.8-1.1-0.5-0.6-0.7-0.6-0.70.70.30.50.2
Soleus weight10.430.856.9-6.6-7.5-6.2-7.4-7.5-6.5-7.3-1.11.1-3.9-1.3-2.2
Bone: stiffness0.71.13.0-1.1-1.2-1.1-1.2-1.1-0.7-0.9-1.11.1-0.4-0.2-1.7
Tibialis anterior weight10.234.560.0-7.4-7.7-7.1-7.5-7.4-6.8-6.6-3.63.6-2.4-0.2-4.0
Time to tail flick, vehicle, before self-admin1.31.44.11.61.21.50.31.22.01.3-0.20.2-0.6-1.2-1.2
Time to tail flick, vehicle, after self-admin0.70.92.0-1.1-0.8-0.8-0.5-0.8-0.7-0.6-1.41.41.01.1-0.7
Time to tail flick, test, before self-admin2.32.35.51.71.21.70.81.21.41.42.3-2.3-0.8-0.71.9
Time to tail flick, test, after self-admin1.51.63.41.81.61.81.51.50.81.00.9-0.9-0.5-1.11.0
Delta time to tail flick, vehicle, before/after SA1.21.13.2-1.5-1.1-1.2-0.4-1.5-1.8-1.4-0.80.80.00.3-0.3
Delta time to tail flick, test, before/after SA0.90.92.8-0.7-0.2-0.80.3-0.3-1.2-0.8-1.71.71.00.8-0.4
Tibia length0.61.65.5-1.3-0.6-1.4-0.1-0.8-1.4-1.70.2-0.21.62.31.2
Ambulatory time before self-admin0.30.41.30.1-0.3-0.5-0.2-0.6-0.8-0.50.5-0.5-1.1-1.1-0.6
Ambulatory time after self-admin2.22.54.5-2.1-1.7-2.0-1.6-1.7-2.1-2.0-1.11.10.61.1-1.2
Bone: tissue strength0.60.61.50.10.70.30.70.81.01.0-0.70.71.20.9-0.8
Total heroin consumption0.91.12.0-0.5-1.1-0.6-1.4-1.2-0.9-1.2-0.90.8-1.1-1.0-1.4
Bone: trabecular number1.21.94.61.71.32.11.11.21.51.21.5-1.5-0.9-1.40.3
Bone: trabecular spacing0.20.21.00.30.40.10.30.41.00.70.2-0.20.20.20.5
Bone: trabecular thickness0.40.42.0-0.00.40.20.60.60.40.4-0.20.21.41.40.4
Bone: trabecular tissue density3.75.512.6-3.3-2.8-3.6-2.3-2.4-2.0-2.0-1.91.91.32.5-0.4
Water consumed over 24 hours0.20.30.60.30.60.20.80.2-0.1-0.5-0.70.70.70.4-0.3
Number of responses in last shaping day0.30.31.0-0.5-0.1-0.2-0.0-0.0-0.6-1.00.3-0.30.60.90.6