Hub : Genes

Rbm4b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Rbm4b	0.02	0.02	8.7e-03	0	0.01	0	0.01	1.6e-01	2.9e-02	2.0e-01	6.9e-02
2	Liver	intron excision ratio	chr1_202049074_202054060	0.04	0.03	6.2e-03	0	0.01	0.01	0	2.6e-01	4.3e-02	2.3e-02	2.0e-01
3	LHb	mRNA stability	Rbm4b	0.3	0.16	9.2e-04	0.09	0.16	0.11	0.12	3.3e-03	1.4e-04	1.4e-03	1.2e-03
4	LHb	gene expression	Rbm4b	0.35	0.17	2.6e-04	0.18	0.15	0.15	0.17	5.4e-05	1.7e-04	1.7e-04	9.4e-05
5	Liver	intron excision ratio	chr1_202054730_202057424	0.04	0.03	5.7e-03	0	0.01	0.02	0	1.3e-01	1.9e-02	2.0e-03	8.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	2.3	3.9	7.6	0.3	-1.5	-2.7	2.8	1.6
Area under the delay curve	0.8	0.9	1.5	0.8	-0.7	-0.8	1.2	1.0
BMI with tail	4.2	13.4	20.0	-1.2	-4.3	-4.3	4.5	2.9
BMI without tail	1.7	3.5	5.9	-0.7	-2.2	-2.2	2.4	1.3
Body weight	2.0	8.3	13.9	-3.5	-3.7	-2.8	2.5	0.9
Weight adjusted by age	1.0	1.2	3.7	-1.9	-1.2	-0.6	0.3	-0.5
Bone surface	4.0	7.1	11.4	-1.5	-3.0	-3.4	2.8	2.2
Bone volume	2.5	4.2	7.8	-0.5	-1.9	-2.8	2.4	1.8
Breakpoint value in progressive ratio session	1.2	1.4	3.8	-1.9	-1.3	-1.0	0.6	0.3
Number of licking bursts	0.1	0.1	0.2	-0.5	-0.3	-0.5	0.3	-0.0
Context. condit. distance diff. score	0.7	0.8	2.5	1.6	1.0	0.7	-0.3	-0.0
Locomotion velocity, session 1	0.2	0.2	0.4	-0.2	0.2	0.7	-0.5	-0.6
Locomotion distance, session 1	1.4	1.8	3.4	-0.1	-1.5	-1.6	1.8	0.9
Locomotion velocity, session 2	1.6	1.8	3.2	-1.6	-1.8	-1.3	1.2	0.5
Locomotion distance, session 2	1.3	1.8	3.2	-0.7	-1.8	-1.4	1.4	1.1
Locomotion velocity, session 3	0.4	0.4	0.8	0.5	-0.6	-0.6	0.6	0.9
Locomotion distance, session 3	0.0	0.0	0.0	0.1	-0.0	0.0	-0.1	0.0
Stereotopy head waving bouts, day 3	0.3	0.4	1.3	1.2	-0.1	-0.3	0.5	0.5
Stereotopy head waving duration, day 3	0.4	0.5	1.9	1.4	0.3	-0.2	0.3	0.6
Locomotion velocity, session 7	0.7	0.7	1.1	0.8	-0.5	-0.8	1.1	1.0
Locomotion distance, session 7	0.2	0.2	0.6	0.1	-0.6	-0.4	0.8	0.3
Stereotopy head waving bouts, day 7	0.4	0.5	1.0	0.8	-0.2	-0.7	0.5	1.0
Stereotopy head waving duration, day 7	1.8	2.1	3.5	-0.3	-1.6	-1.9	1.4	1.6
Locomotion velocity, session 8	0.4	0.5	1.5	-1.2	-0.8	-0.1	0.0	-0.2
Locomotion distance, session 8	0.1	0.2	0.5	0.7	0.0	-0.1	0.4	0.3
Degree of sensitization distance	0.6	0.6	1.2	0.2	-0.8	-0.7	1.1	0.7
Degree of sensitization stereotypy	0.5	0.6	1.2	-0.3	-0.8	-1.1	0.6	0.8
Conditioned locomotion	0.8	0.9	3.5	-1.9	-0.5	0.2	-0.4	-0.9
Cocaine response after cond. corrected	0.6	0.6	1.0	1.0	1.0	0.7	-0.4	-0.8
Cocaine response after cond. not corrected	0.3	0.3	1.1	1.0	0.6	0.3	-0.1	-0.3
Cocaine response before conditioning	0.5	0.6	1.1	-0.5	-0.9	-0.9	0.5	1.0
Saline control response	2.1	2.8	4.8	-2.0	-2.2	-1.6	1.5	0.7
Bone: connectivity density	3.6	5.6	10.0	-0.8	-2.4	-3.2	3.0	1.6
Bone: cortical apparent density	0.2	0.3	0.8	-0.7	-0.2	0.1	-0.1	-0.9
Bone: cortical area	0.3	0.4	1.8	-1.3	-0.1	0.1	-0.4	-0.3
Bone: cortical porosity	0.7	0.7	1.2	0.2	-0.7	-1.0	1.1	0.9
Bone: cortical porosity	0.7	0.7	1.2	-0.4	-0.9	-1.1	1.1	0.7
Bone: cortical thickness	1.7	2.7	10.0	-3.2	-0.6	0.5	-0.8	-1.5
Bone: cortical thickness	1.0	1.1	2.8	-1.7	-0.2	0.8	-0.7	-1.3
Bone: cortical tissue density	0.3	0.3	0.9	-0.8	-0.2	0.1	-0.2	-0.9
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	-0.2	-0.9	-0.8	0.6	0.9
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.3	0.0	-0.4	-0.4	0.2	0.6
Condit. Reinf. active responses	0.2	0.3	0.5	-0.2	-0.7	-0.5	0.3	0.7
Condit. Reinf. inactive responses	0.0	0.1	0.2	0.1	-0.2	-0.2	0.1	0.4
Incentive salience index mean	0.6	0.7	1.2	-0.3	-1.1	-0.9	0.7	0.9
Condit. Reinf. lever presses	0.1	0.1	0.4	-0.6	-0.4	-0.3	-0.1	0.2
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	0.9	0.0	-0.7	0.6	0.8
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.4	1.2	0.7	-0.1	-0.0	0.7
Condit. Reinf. active responses	1.1	1.6	2.7	0.6	-0.9	-1.6	1.6	1.2
Condit. Reinf. inactive responses	1.9	2.3	4.3	-0.1	-1.6	-1.9	2.1	1.1
Condit. Reinf. lever presses	1.6	2.2	3.2	-1.4	-1.7	-1.8	1.4	1.1
Condit. Reinf. lever reinforcers received	1.1	1.6	2.9	0.2	-1.1	-1.7	1.6	1.2
Conditioned reinforcement - actives	0.3	0.3	0.8	0.3	0.9	0.6	-0.7	-0.2
Conditioned reinforcement - inactives	2.9	3.3	6.4	2.5	2.3	1.4	-1.5	-0.2
Conditioned locomotion	5.5	6.6	11.4	2.8	3.4	2.6	-2.4	-1.0
Patch foraging indifference point 0 sec	0.1	0.1	0.3	0.5	0.2	-0.3	0.3	0.0
Patch foraging indifference point AUC	1.4	1.6	4.6	-2.1	-1.5	-0.9	0.4	0.1
Delay disc. indifference point, 0s delay	0.5	0.5	1.4	1.2	-0.2	-0.4	1.0	0.2
Delay disc. indifference point, 16s delay	0.7	0.7	1.9	1.4	0.1	-0.4	0.5	1.1
Delay disc. indifference point, 2s delay	0.1	0.2	0.4	0.6	0.1	-0.1	0.2	0.6
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.0	0.1	0.4	-0.1	-0.4
Delay disc. indifference point, 4s delay	0.4	0.4	0.9	0.7	-0.4	-0.4	1.0	0.5
Delay disc. indifference point, 8s delay	0.3	0.4	0.9	0.5	-0.5	-0.5	1.0	0.4
Indifference point function ln k	3.9	5.5	10.3	3.2	3.0	2.3	-1.5	-0.8
Indifference point function log k	3.9	5.5	10.3	3.2	3.0	2.3	-1.5	-0.8
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	0.1	0.3	0.2	-0.1	-0.4
Patch foraging total patch changes 12 sec	2.6	3.3	5.3	-2.3	-2.3	-1.8	1.6	0.4
Patch foraging total patch changes 18 sec	0.5	0.7	1.2	-0.6	-0.9	-1.1	1.1	0.0
Patch foraging total patch changes 24 sec	0.9	1.1	3.5	-1.9	-1.1	-0.6	0.5	-0.4
Patch foraging total patch changes 6 sec	1.1	1.6	2.8	-1.1	-1.7	-1.5	1.3	0.7
Patch foraging time to switch 0 sec	3.5	5.4	7.7	-1.0	-2.8	-2.6	2.3	2.5
Patch foraging water rate 0 sec	5.6	9.0	14.8	1.8	3.8	3.2	-3.0	-2.8
Patch foraging water rate 12 sec	7.5	11.4	18.4	2.7	4.3	3.8	-3.1	-2.7
Patch foraging water rate 18 sec	2.0	2.7	4.3	1.7	2.1	1.9	-1.4	-1.0
Patch foraging water rate 24 sec	5.1	7.1	11.0	1.8	3.3	2.8	-2.6	-2.6
Patch foraging water rate 6 sec	4.3	6.2	9.4	1.4	3.1	2.8	-2.3	-2.6
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.1	0.5	-0.6	-1.0	1.0	0.7
Distance traveled before self-admin	0.1	0.1	0.2	-0.5	-0.5	-0.3	0.2	0.2
Distance traveled after self-admin	0.1	0.1	0.2	-0.3	-0.5	-0.2	0.0	0.5
Extensor digitorum longus weight	3.0	11.7	31.2	-5.6	-4.1	-2.6	1.9	-0.1
Bone: elastic displacement	2.5	2.8	4.2	0.1	1.8	2.0	-1.7	-2.1
Bone: elastic work	0.9	1.2	2.7	-1.7	-0.1	0.8	-0.6	-1.5
Bone: endosteal estimation	0.8	1.8	4.6	2.1	0.0	-0.8	1.0	1.7
Bone: endosteal perimeter	1.5	3.2	6.8	2.6	-0.1	-1.1	1.2	2.6
Epididymis fat weight	1.3	3.0	8.4	2.9	2.3	0.8	-0.5	-0.7
Delta time in closed arm before/after self-admin	0.5	0.5	2.1	-0.6	-0.0	0.2	0.1	-1.5
Delta time in open arm before/after self-admin	0.1	0.1	0.3	-0.1	0.0	0.2	-0.4	0.5
Diff in mean of infusions in LGA sessions	0.3	0.4	0.9	-1.0	0.2	0.1	-0.3	-0.9
Delay discount exponential model param	0.6	0.7	1.2	-0.6	0.7	0.7	-1.1	-0.9
Extinction: sum of active levers before priming	2.5	2.5	3.5	-1.9	-1.8	-1.7	1.4	0.6
Active lever presses in extinction session 6	0.9	0.9	3.7	-1.9	-0.5	0.2	-0.7	-0.4
Bone: final force	1.1	1.8	3.6	-1.9	-1.7	-1.2	0.9	0.6
Bone: final moment	0.9	1.5	3.1	-1.8	-1.5	-1.1	0.9	0.5
Food consumed during 24 hour testing period	0.2	0.2	0.6	-0.3	0.4	0.5	-0.8	0.0
Glucose	1.2	1.8	5.5	2.3	0.2	-0.7	0.9	1.4
Heart weight	1.1	1.5	5.1	2.3	1.4	0.5	-0.1	-0.4
Delay discount hyperbolic model param	0.5	0.6	1.0	-0.6	0.6	0.7	-1.0	-0.8
Intermittent access intake day 1-15 change	1.0	1.0	1.7	0.2	1.2	1.2	-1.3	-0.8
Intermittent access intake escalation	0.5	0.5	0.8	0.3	0.9	0.8	-0.9	-0.5
Intermittent access intake escalation 2	0.9	0.9	1.8	-0.1	0.9	1.2	-1.3	-0.7
Intermitt. access day 1 inactive lever presses	0.9	1.0	2.5	1.6	0.9	0.6	-0.7	0.8
Intermitt. access day 15 inactive lever presses	0.7	0.8	1.9	1.4	0.8	0.5	-0.7	0.6
Intermitt. access escalation Index	1.5	1.3	5.1	2.3	1.2	0.2	0.3	0.0
Intermittent access day 1 total infusions	2.8	3.3	10.9	3.3	0.7	-1.0	1.2	1.6
Intermittent access day 15 total infusions	2.6	3.0	10.0	3.2	2.0	0.5	-0.5	0.4
Intermittent access terminal intake (last 3 days)	1.9	2.0	7.4	2.7	1.4	0.1	-0.1	0.8
Intermittent access total infusions	1.9	2.1	7.3	2.7	0.8	-0.7	0.8	1.2
Intermittent access day 1 locomotion	2.6	2.7	6.6	2.6	-0.2	-1.3	1.4	1.9
Intermittent access day 15 total locomotion	1.5	1.7	6.2	2.5	1.4	0.2	-0.2	0.5
Intermittent access total locomotion	2.7	3.1	11.2	3.3	0.8	-0.8	0.8	1.6
Intermittent access standard deviation	0.6	0.6	0.9	0.8	0.9	0.9	-0.9	-0.4
Left kidney weight	0.8	2.1	3.9	1.0	2.0	1.5	-1.5	-1.0
Right kidney weight	1.1	3.0	5.0	0.2	2.2	1.5	-2.0	-2.0
Cocaine induced anxiety	0.1	0.1	0.4	-0.2	0.3	0.3	-0.6	-0.3
Post-drug Anxiety	0.6	0.7	2.5	-1.6	-0.3	0.2	-0.7	-0.5
Baseline Anxiety	0.8	0.9	3.5	-1.9	-0.9	-0.2	0.2	-0.2
Tail length	0.9	2.8	4.9	-2.2	0.4	1.4	-1.4	-2.2
Length with tail	0.9	3.4	12.9	-3.6	-1.2	0.1	-0.5	-1.5
Length without tail	1.0	2.2	6.7	-2.6	-1.7	-1.0	0.6	-0.1
Times rat made contact with spout	0.7	0.8	1.3	-0.5	-1.1	-1.0	1.1	0.6
Lifetime Intake	1.8	2.1	6.7	2.6	0.7	-0.9	1.0	1.2
Liver weight, left	0.1	0.2	0.4	0.2	0.6	0.6	-0.5	-0.3
Liver weight, right	0.1	0.1	0.3	0.1	0.3	0.4	-0.2	-0.6
Locomotor activity	2.0	3.1	4.5	1.0	2.1	2.0	-1.4	-2.1
Locomotor testing distance	2.1	3.6	4.9	1.3	2.2	2.2	-1.4	-2.2
Locomotor testing rearing	0.7	1.0	2.9	1.7	1.2	0.8	-0.2	-0.5
Locomotion in novel chamber	2.4	3.0	6.2	2.5	2.2	1.4	-1.3	-0.1
Locomotion in novel chamber post-restriction	1.4	1.6	3.5	1.9	1.7	1.1	-0.6	0.1
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	-0.1	0.3	-0.0	-0.4	-0.2
Change in fecal boli incidents, locomotor task	0.4	0.4	0.9	0.2	-0.7	-0.5	0.9	0.3
Time >=10cm from walls, locomotor time 1	1.3	1.3	2.4	1.5	-0.3	-1.2	1.0	1.2
Bouts of movement, locomotor time 1	0.4	0.4	1.4	-1.2	-0.6	-0.6	0.2	-0.0
Total resting periods, locomotor time 1	0.3	0.4	0.8	-0.9	-0.6	-0.7	0.3	0.2
Rest time, locomotor task time 1	1.3	1.5	2.5	1.1	1.6	1.3	-1.4	-0.3
Distance moved, locomotor task time 1	1.0	1.0	1.7	-0.0	-1.1	-1.2	1.3	0.8
Vertical activity count, locomotor time 1	0.5	0.6	0.9	0.9	1.0	0.5	-0.3	-0.8
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.2	0.1	-0.1	-0.1	0.2
Bouts of movement, locomotor time 2	0.3	0.4	0.6	-0.8	-0.7	-0.7	0.5	0.0
Total resting periods, locomotor time 2	0.3	0.3	0.5	-0.4	-0.7	-0.7	0.5	0.3
Rest time, locomotor task time 2	1.0	1.2	2.9	1.7	1.3	0.9	-0.7	-0.0
Distance moved, locomotor task time 2	0.4	0.5	1.5	-1.2	-0.7	-0.4	0.2	-0.2
Vertical activity count, locomotor time 2	1.4	1.5	3.2	-0.8	0.9	1.3	-1.1	-1.8
Light reinforcement 1	0.2	0.3	0.5	0.5	0.7	0.5	-0.3	-0.6
Light reinforcement 2	1.0	1.3	2.6	1.1	1.6	0.9	-1.3	-0.3
Bone: marrow area	0.8	1.8	4.8	2.2	0.1	-0.7	1.0	1.7
Bone: maximum diameter	0.0	0.1	0.2	-0.3	0.1	0.0	-0.4	0.3
Bone: maximum force	2.6	4.5	7.3	-1.6	-2.7	-2.4	2.0	1.7
Bone: maximum moment	2.2	3.9	6.1	-1.5	-2.5	-2.3	1.9	1.6
Mean time between licks in bursts	0.2	0.2	0.6	-0.8	-0.7	-0.0	0.2	-0.1
Mean num. licks in bursts	0.1	0.1	0.2	0.5	-0.2	-0.1	0.4	0.5
Cd content in liver	1.5	1.6	3.1	1.0	1.8	1.3	-1.3	-0.8
Co content in liver	1.6	1.8	3.9	0.5	1.3	2.0	-1.5	-1.0
Cu content in liver	0.4	0.5	0.7	-0.5	-0.9	-0.7	0.6	0.7
Fe content in liver	0.1	0.1	0.2	-0.5	0.1	0.2	-0.2	-0.3
K content in liver	2.7	2.7	4.4	-0.9	-2.1	-1.9	1.5	1.6
Mg content in liver	3.7	3.8	5.3	0.6	-1.9	-2.3	2.1	2.3
Mn content in liver	1.1	1.3	2.7	-1.6	-1.3	-1.3	0.5	0.0
Na content in liver	0.4	0.4	1.4	-1.2	0.0	0.3	-0.6	-0.4
Rb content in liver	1.1	1.3	3.4	1.8	-0.1	-0.7	1.1	1.3
Se content in liver	0.6	0.7	1.4	0.4	-0.5	-1.1	0.8	1.2
Sr content in liver	1.1	1.0	3.9	-2.0	-0.5	0.2	-0.6	-0.6
Zn content in liver	0.8	0.9	1.6	-1.1	-1.3	-0.9	0.6	0.7
Bone: minimum diameter	1.3	2.5	4.1	1.9	-0.5	-1.4	1.6	2.0
Time in familiar zone, hab. session 1	0.4	0.4	1.0	0.8	-0.2	-0.4	0.4	1.0
Time in novel zone, hab. session 1	0.5	0.5	0.9	0.0	0.6	1.0	-0.7	-0.8
Total zone transitions, hab. session 1	0.5	0.7	1.2	-0.9	-1.1	-0.8	0.8	0.3
Total locomotion distance, hab. session 1	0.1	0.2	0.6	0.8	0.4	0.1	0.2	0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.3	0.0	-0.2	0.4	-0.0
Time in familiar zone, hab. session 2	0.2	0.2	0.4	-0.4	0.0	0.6	-0.4	-0.6
Time in novel zone, hab. session 2	0.6	0.6	1.1	0.3	-0.5	-1.0	0.9	0.8
Total zone transitions, hab. session 2	4.3	5.6	9.7	-0.1	-2.6	-2.9	3.1	1.7
Total locomotion distance, hab. session 2	1.1	1.5	3.4	0.8	-0.9	-1.4	1.9	0.8
Locomotion velocity, hab. session 2	1.0	1.4	3.0	1.0	-0.7	-1.3	1.7	0.8
Novel to familiar place preference ratio	0.8	0.9	1.5	-0.5	-0.9	-1.2	0.8	1.0
Novelty place preference	0.6	0.6	1.1	-0.1	-0.7	-1.1	0.7	1.1
Time in novel zone, NPP test	0.6	0.6	1.1	-0.0	-0.6	-1.0	0.7	1.0
Total zone transitions, NPP test	1.5	2.2	3.4	-1.1	-1.8	-1.7	1.6	0.7
Total locomotion distance, NPP test	0.2	0.2	0.6	0.1	-0.4	-0.6	0.8	0.1
Locomotion velocity, NPP test	0.1	0.2	0.5	0.0	-0.3	-0.5	0.7	0.1
Intraocular pressure	1.8	2.5	4.3	0.5	2.1	1.4	-1.6	-1.7
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.0	0.2	0.2	-0.2	-0.2
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	-0.1	-0.0	0.2	-0.1	-0.3
Parametrial fat weight	1.0	1.9	7.1	2.7	1.4	0.1	0.3	0.4
Pavlov. Cond. lever latency	0.1	0.2	0.4	0.3	0.6	0.5	-0.1	-0.5
Pavlov. Cond. magazine entry latency	0.6	0.8	1.7	0.4	-0.7	-1.3	1.0	0.8
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	0.3	-0.1	-0.6	0.1	0.7
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.3	0.1
Pavlov. Cond. latency score	0.0	0.0	0.1	0.1	-0.2	-0.3	-0.1	0.3
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.3	-0.1	0.1	0.5	0.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.6	0.2	0.8	0.7	-0.8	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.2	-0.3	-0.4	-0.1	0.2
Pavlov. Cond. response bias	0.0	0.1	0.2	-0.2	0.1	-0.1	-0.4	-0.2
Pavlov. Cond. lever latency	0.3	0.4	0.6	0.7	0.6	0.7	-0.5	-0.6
Pavlov. Cond. magazine entry latency	3.3	3.8	6.2	-1.7	-2.5	-2.1	1.8	1.5
Pavlov. Cond. change in total contacts	1.6	2.2	3.5	-1.0	-1.5	-1.9	1.3	1.6
Pavlov. Cond. index score	1.9	2.4	3.3	-1.4	-1.8	-1.7	1.3	1.5
Pavlov. Cond. latency score	1.5	1.9	2.6	-1.3	-1.6	-1.5	1.0	1.4
Pavlov. Cond. lever contacts	0.2	0.2	0.7	-0.8	-0.3	-0.3	0.1	0.4
Pavlov. Cond. magazine entry number	4.7	5.7	9.1	2.3	3.0	2.6	-2.1	-1.7
Pavlov. Cond. intertrial magazine entries	0.8	1.1	1.9	1.2	1.4	0.9	-0.8	-0.7
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.8	4.0	-1.6	-2.0	-1.8	1.4	1.5
Pavlov. Cond. response bias	1.1	1.5	2.0	-1.3	-1.4	-1.3	1.0	1.0
Time in closed arm before self-admin	0.2	0.2	0.6	0.3	-0.2	-0.4	0.2	0.8
Time in closed arm after self-admin	0.1	0.1	0.5	0.0	0.2	-0.1	0.1	-0.7
Time in open arm before self-admin	0.1	0.2	0.4	0.4	0.3	0.4	0.1	-0.6
Time in open arm after self-admin	0.2	0.3	0.6	0.1	0.5	0.8	-0.6	0.0
Bone: periosteal estimation	0.1	0.2	0.6	0.4	-0.1	-0.3	0.2	0.8
Bone: periosteal perimeter	0.4	0.6	1.6	0.2	-0.6	-0.9	0.7	1.3
Bone: post-yield work	6.7	9.1	13.7	1.2	-2.5	-3.7	3.3	3.7
Progressive ratio test 1 active lever presses	0.9	0.9	3.2	1.8	1.2	0.3	-0.1	0.3
Progressive ratio test 1 breakpoint	0.8	0.8	2.6	1.6	1.1	0.4	-0.3	0.2
Progressive ratio test 1 inactive lever presses	0.4	0.4	1.6	1.3	0.3	-0.1	0.1	0.4
Progressive ratio test 2 active lever presses	1.2	1.3	4.9	2.2	1.1	0.3	-0.2	0.6
Progressive ratio test 2 breakpoint	1.7	1.9	5.4	2.3	1.7	0.9	-0.8	0.2
Progressive ratio test 2 inactive lever presses	2.8	3.3	12.5	3.5	1.7	0.5	-0.4	0.7
Incentive Sensitization - Responses	0.2	0.2	0.5	0.7	0.1	-0.3	0.2	0.6
Incentive Sensitization - Breakpoint	0.2	0.2	0.7	0.8	0.2	-0.1	0.0	0.5
Sum of active levers in priming session hrs 5-6	2.0	2.0	3.2	-1.8	0.7	0.9	-1.6	-1.7
Progressive ratio	3.5	4.1	7.0	-0.5	-1.9	-2.6	2.6	1.6
Food seeking constrained by brief footshock	0.2	0.2	0.5	-0.7	-0.5	-0.0	0.1	-0.5
Seeking ratio, punishment vs. effort	2.4	3.0	5.1	0.5	1.6	2.3	-2.0	-1.6
Retroperitoneal fat weight	2.2	7.3	21.0	4.6	3.5	1.5	-0.9	-0.4
Reaction time number correct	0.6	0.9	2.3	-1.0	0.4	0.6	-0.8	-1.5
Reaction time mean minus median	1.3	1.7	3.5	-1.9	-1.4	-1.4	1.0	0.1
Reaction time mean minus median AUC	0.7	0.9	3.1	-1.8	-0.5	-0.4	0.1	-0.9
Reaction time num false alarms	0.7	1.0	1.8	-0.2	0.9	1.3	-0.8	-1.4
Reaction time num false alarms AUC	0.5	0.6	1.5	-0.8	0.2	0.8	-0.5	-1.2
Reaction time trials correct on left	0.6	0.9	2.3	-1.0	0.4	0.6	-0.8	-1.5
Reaction time trials on left	0.7	1.1	2.6	-1.1	0.4	0.7	-0.9	-1.6
Reaction time mean	0.0	0.0	0.0	-0.0	0.1	-0.2	0.1	-0.0
Reaction time mean AUC	0.0	0.0	0.1	0.1	0.1	-0.3	0.2	0.2
Median of all reaction times	0.0	0.1	0.2	0.5	0.2	-0.1	0.1	0.2
Reaction time omissions	0.6	0.8	2.7	-1.7	-0.8	-0.5	0.3	-0.8
Reaction time false alarm rate	0.1	0.2	0.5	-0.1	0.3	0.7	-0.3	-0.5
Reaction time premature initiation rate	0.9	1.2	3.7	-1.9	-1.2	-0.3	0.4	-0.7
Reaction time premature initiations	1.5	2.1	7.3	-2.7	-1.1	-0.0	-0.0	-1.4
Std. dev. reaction times	0.3	0.4	1.0	-1.0	-0.5	-0.7	0.4	-0.1
Reaction time trials completed	0.7	1.1	2.6	-1.1	0.4	0.7	-0.9	-1.6
Reaction time trials AUC	0.6	0.8	2.2	-0.9	0.4	0.6	-0.8	-1.5
Run reversals in cocaine runway, females	1.5	1.5	3.2	-0.3	-1.4	-1.4	1.8	0.4
Run reversals in cocaine runway, males	2.7	2.6	4.2	-0.6	1.2	2.0	-2.1	-1.7
Latency to leave start box in cocaine runway	1.0	1.1	2.3	0.5	-0.8	-1.0	1.0	1.5
Latency to leave start box in cocaine runway, F	0.5	0.6	1.1	0.3	-0.6	-0.8	0.9	1.0
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.0	-0.3	-0.2	0.1	0.5
Std. dev. time between licks in bursts	0.6	0.7	1.3	-0.3	0.5	1.2	-0.8	-1.1
Total sessions with >9 infusions	0.7	0.8	2.6	1.6	0.5	-0.4	0.7	0.6
Short access day 1 total inactive lever presses	1.5	1.6	5.6	2.4	1.5	0.6	-0.3	0.3
Short access day 10 total inactive lever presses	1.2	1.3	2.9	1.7	1.2	1.1	-1.0	0.1
Short access day 1 total infusions	1.8	1.9	6.1	2.5	0.6	-0.8	1.1	1.2
Short access day 10 total infusions	3.2	3.5	5.2	2.0	-0.6	-2.2	2.3	1.8
Short access total infusions	1.4	1.6	3.0	1.7	-0.1	-1.2	1.5	1.1
Short access day 1 locomotion	1.7	1.8	4.1	2.0	-0.1	-1.1	1.2	1.5
Short access day 10 total locomotion	1.4	1.6	3.2	1.8	-0.4	-1.2	1.3	1.3
Short access total locomotion	1.6	1.6	2.7	1.7	-0.5	-1.2	1.3	1.5
One hour access (0.3 mA shock)	3.3	3.9	11.4	3.4	2.4	1.1	-1.0	0.2
Compulsive drug intake	1.1	1.1	4.1	-2.0	-1.1	-0.1	0.2	-0.5
One hour access (shock baseline)	3.3	3.8	11.2	3.3	2.5	0.9	-1.0	0.3
Social response proportion	1.4	1.5	2.4	-0.6	-1.6	-1.2	1.0	1.5
Social responses	0.2	0.3	0.6	-0.7	-0.8	-0.3	0.2	0.6
Social time	0.2	0.3	0.6	-0.8	-0.7	-0.1	0.1	0.4
Soleus weight	2.3	6.9	11.9	3.2	3.5	2.6	-2.1	-0.7
Bone: stiffness	2.8	4.4	6.6	-1.1	-2.6	-2.4	2.0	2.0
Tibialis anterior weight	3.6	12.5	46.6	-6.8	-3.6	-1.3	0.3	-1.0
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.0	-0.4	-1.0	-1.0	0.9	0.1
Time to tail flick, vehicle, after self-admin	1.5	1.6	2.8	-1.0	-1.7	-1.4	1.5	0.4
Time to tail flick, test, before self-admin	1.4	1.3	2.2	1.1	-0.9	-0.9	1.4	1.5
Time to tail flick, test, after self-admin	0.1	0.1	0.4	-0.2	0.1	0.1	-0.3	-0.7
Delta time to tail flick, vehicle, before/after SA	1.0	1.0	1.8	-0.5	-1.3	-0.9	0.9	1.1
Delta time to tail flick, test, before/after SA	2.5	2.3	4.5	-1.6	0.8	1.0	-1.6	-2.1
Tibia length	0.4	1.1	3.6	-1.9	0.1	0.3	-1.1	-0.6
Ambulatory time before self-admin	0.2	0.2	0.4	-0.4	-0.6	-0.5	0.1	0.4
Ambulatory time after self-admin	0.4	0.4	0.9	0.7	-0.3	-0.6	0.4	1.0
Bone: tissue strength	0.2	0.2	0.3	0.1	-0.3	-0.6	0.4	0.6
Total heroin consumption	1.8	2.1	6.4	-2.5	-1.4	-1.1	0.9	-0.2
Bone: trabecular number	2.0	3.2	6.5	0.0	-1.4	-2.6	2.3	1.4
Bone: trabecular spacing	0.4	0.5	1.0	0.3	0.5	1.0	-0.9	-0.6
Bone: trabecular thickness	1.0	1.1	2.2	1.2	0.0	-1.2	1.5	0.8
Bone: trabecular tissue density	2.6	3.7	5.8	1.9	2.4	2.1	-2.0	-0.7
Water consumed over 24 hours	0.4	0.5	0.8	-0.9	-0.9	-0.8	0.7	0.1
Number of responses in last shaping day	0.5	0.5	0.8	0.9	0.7	0.8	-0.7	0.1