Hub : Genes

Rbm4b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr1_211478477_211483463	0.04	0.03	3.8e-03	0	0.01	0.01	0	2.7e-01	2.5e-02	7.8e-03	1.5e-01
2	Liver	intron excision ratio	chr1_211484133_211486827	0.04	0.03	3.8e-03	0	0.01	0.03	0.01	9.7e-02	1.3e-02	7.2e-04	7.1e-02
3	LHb	mRNA stability	Rbm4b	0.29	0.17	1.5e-03	0.1	0.16	0.07	0.11	2.5e-03	1.3e-04	1.0e-02	1.2e-03
4	LHb	gene expression	Rbm4b	0.38	0.18	1.1e-04	0.18	0.17	0.19	0.18	5.6e-05	8.8e-05	3.3e-05	3.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	2.9	5.0	7.3	1.8	-1.6	-2.7	-2.7
Area under the delay curve	0.8	0.9	1.5	0.8	-0.9	-0.9	-1.2
BMI with tail	4.5	15.6	19.4	3.7	-3.6	-4.4	-4.1
BMI without tail	2.2	6.6	7.8	2.3	-2.5	-2.7	-2.8
Body weight	2.4	10.5	13.3	3.5	-3.7	-2.8	-2.8
Weight adjusted by age	0.4	0.5	0.9	0.9	-1.0	-0.4	-0.4
Bone surface	5.2	9.5	11.0	3.2	-3.0	-3.3	-2.8
Bone volume	3.1	5.6	7.3	2.3	-2.1	-2.7	-2.3
Breakpoint value in progressive ratio session	1.5	1.7	2.1	1.4	-1.4	-1.2	-1.2
Number of licking bursts	0.3	0.5	0.8	0.9	-0.8	-0.6	-0.5
Context. condit. distance diff. score	1.2	1.5	2.7	-1.6	1.6	0.7	0.4
Locomotion velocity, session 1	0.5	0.5	1.2	0.3	-0.5	0.7	1.1
Locomotion distance, session 1	2.4	3.0	3.2	1.8	-1.8	-1.6	-1.8
Locomotion velocity, session 2	2.1	2.4	4.0	1.9	-2.0	-1.1	-0.8
Locomotion distance, session 2	2.0	2.7	3.9	1.8	-2.0	-1.3	-1.4
Locomotion velocity, session 3	0.3	0.3	0.4	0.6	-0.7	-0.6	-0.3
Locomotion distance, session 3	0.1	0.2	0.3	0.4	-0.5	-0.0	0.4
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	-0.1	0.0	-0.3	-0.2
Stereotopy head waving duration, day 3	0.2	0.2	0.3	-0.5	0.6	-0.3	-0.3
Locomotion velocity, session 7	0.2	0.2	0.7	-0.1	0.1	-0.8	-0.5
Locomotion distance, session 7	0.1	0.1	0.2	0.2	-0.3	-0.5	-0.5
Stereotopy head waving bouts, day 7	0.3	0.3	1.0	0.4	-0.2	-1.0	-0.3
Stereotopy head waving duration, day 7	1.2	1.5	2.9	1.1	-0.9	-1.7	-1.0
Locomotion velocity, session 8	0.5	0.6	1.3	1.0	-1.1	-0.1	-0.2
Locomotion distance, session 8	0.0	0.1	0.2	-0.2	0.2	-0.1	-0.4
Degree of sensitization distance	0.3	0.3	0.6	0.2	-0.3	-0.7	-0.8
Degree of sensitization stereotypy	0.4	0.4	1.0	0.6	-0.5	-1.0	-0.2
Conditioned locomotion	0.3	0.3	0.8	0.7	-0.9	-0.0	-0.1
Cocaine response after cond. corrected	0.8	0.9	1.4	-1.2	1.1	0.8	0.6
Cocaine response after cond. not corrected	0.3	0.4	0.6	-0.8	0.7	0.5	0.3
Cocaine response before conditioning	0.7	0.8	1.3	1.2	-1.0	-0.8	-0.6
Saline control response	2.7	3.5	5.1	2.2	-2.3	-1.4	-1.5
Bone: connectivity density	5.0	7.9	9.9	2.5	-2.4	-3.1	-3.1
Bone: cortical apparent density	0.1	0.1	0.3	-0.1	0.1	0.5	0.5
Bone: cortical area	0.1	0.1	0.3	0.5	-0.4	-0.0	-0.1
Bone: cortical porosity	0.9	1.0	1.7	0.8	-0.7	-1.0	-1.3
Bone: cortical porosity	0.9	1.0	1.7	0.8	-0.8	-1.0	-1.3
Bone: cortical thickness	0.5	0.8	1.2	1.0	-1.1	0.6	0.7
Bone: cortical thickness	0.5	0.6	0.7	0.6	-0.8	0.7	0.8
Bone: cortical tissue density	0.1	0.1	0.3	-0.0	-0.0	0.5	0.5
Condit. Reinf. active minus inactive responses	0.9	1.0	1.5	1.2	-1.2	-0.9	-0.6
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.6	0.8	-0.6	-0.6	-0.4
Condit. Reinf. active responses	0.5	0.6	0.8	0.9	-0.8	-0.6	-0.7
Condit. Reinf. inactive responses	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.3
Incentive salience index mean	0.9	1.1	1.2	1.1	-1.0	-1.0	-1.0
Condit. Reinf. lever presses	0.2	0.3	0.5	0.5	-0.4	-0.5	-0.7
Condit. Reinf. active minus inactive responses	0.3	0.3	0.7	0.4	-0.3	-0.8	-0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.2	0.4	-0.2	-0.0
Condit. Reinf. active responses	1.3	1.9	2.9	1.2	-1.1	-1.7	-1.4
Condit. Reinf. inactive responses	1.9	2.4	3.2	1.3	-1.4	-1.8	-1.7
Condit. Reinf. lever presses	1.8	2.5	3.2	1.8	-1.7	-1.7	-1.1
Condit. Reinf. lever reinforcers received	1.5	2.0	2.9	1.3	-1.2	-1.7	-1.4
Conditioned reinforcement - actives	0.1	0.2	0.3	-0.3	0.4	0.5	0.5
Conditioned reinforcement - inactives	0.9	1.4	2.1	-1.2	1.5	0.8	1.1
Conditioned locomotion	4.1	5.4	7.6	-2.6	2.8	2.0	1.7
Patch foraging indifference point 0 sec	0.1	0.2	0.4	0.3	-0.2	-0.4	-0.7
Patch foraging indifference point AUC	0.2	0.3	0.5	0.7	-0.7	-0.4	0.3
Delay disc. indifference point, 0s delay	0.4	0.5	1.5	0.0	-0.1	-0.6	-1.2
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.2	-0.1	-0.5	-0.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	0.1	-0.1	-0.4	-0.5
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.2	0.0	0.5	0.1
Delay disc. indifference point, 4s delay	0.5	0.6	1.6	0.3	-0.4	-0.6	-1.3
Delay disc. indifference point, 8s delay	0.4	0.5	0.9	0.5	-0.6	-0.6	-1.0
Indifference point function ln k	2.4	4.1	5.6	-2.4	2.2	2.1	1.2
Indifference point function log k	2.4	4.1	5.6	-2.4	2.2	2.1	1.2
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	0.2	-0.2	0.1	-0.2
Patch foraging total patch changes 12 sec	1.7	2.3	2.5	1.6	-1.6	-1.6	-1.2
Patch foraging total patch changes 18 sec	0.5	0.7	1.0	0.9	-0.9	-1.0	-0.6
Patch foraging total patch changes 24 sec	0.4	0.6	1.2	1.1	-1.1	-0.3	-0.2
Patch foraging total patch changes 6 sec	1.1	1.7	2.2	1.5	-1.5	-1.3	-0.8
Patch foraging time to switch 0 sec	3.0	6.1	7.9	2.2	-2.0	-2.8	-2.8
Patch foraging water rate 0 sec	4.1	8.6	10.4	-2.9	2.9	3.2	2.7
Patch foraging water rate 12 sec	5.4	11.3	13.8	-3.6	3.4	3.7	2.7
Patch foraging water rate 18 sec	1.7	2.6	3.4	-1.7	1.6	1.8	1.2
Patch foraging water rate 24 sec	5.5	7.7	8.8	-3.0	2.8	2.9	2.4
Patch foraging water rate 6 sec	3.6	5.2	8.9	-2.1	1.9	3.0	1.9
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	3.0	0.9	-0.8	-1.1	-1.7
Distance traveled before self-admin	0.5	0.7	1.0	0.8	-0.7	-1.0	-0.6
Distance traveled after self-admin	0.2	0.3	0.4	0.6	-0.6	-0.4	0.5
Extensor digitorum longus weight	2.8	10.8	19.3	4.2	-4.4	-2.1	-1.5
Bone: elastic displacement	2.1	2.4	4.2	-1.2	1.0	2.0	1.8
Bone: elastic work	0.4	0.5	0.7	0.4	-0.6	0.8	0.9
Bone: endosteal estimation	0.3	0.6	1.3	-0.2	0.3	-0.9	-1.1
Bone: endosteal perimeter	0.3	0.6	1.6	0.2	0.1	-1.3	-0.9
Epididymis fat weight	2.1	7.1	12.3	-3.2	3.5	1.8	1.6
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.1	-0.3	0.1	-0.3
Delta time in open arm before/after self-admin	0.2	0.2	0.7	-0.0	0.2	-0.1	0.8
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	-0.0	0.1	-0.2	-0.2
Delay discount exponential model param	0.7	0.8	1.3	-0.8	0.9	0.8	1.1
Extinction: sum of active levers before priming	2.3	2.5	3.9	1.3	-1.2	-1.7	-2.0
Active lever presses in extinction session 6	0.9	0.9	1.7	1.3	-1.2	-0.7	0.0
Bone: final force	1.0	1.7	2.7	1.6	-1.6	-1.0	-0.7
Bone: final moment	1.1	1.7	2.7	1.6	-1.6	-1.0	-0.8
Food consumed during 24 hour testing period	0.3	0.5	0.8	-0.5	0.6	0.6	0.9
Glucose	0.2	0.3	0.7	-0.2	0.3	-0.8	-0.7
Heart weight	0.9	1.4	3.5	-0.1	0.1	-1.4	-1.9
Delay discount hyperbolic model param	0.7	0.8	1.3	-0.7	0.8	0.8	1.1
Intermittent access intake day 1-15 change	0.9	1.8	2.4	-1.4	1.5	1.1	1.2
Intermittent access intake escalation	0.9	1.8	2.1	-1.3	1.4	1.2	1.4
Intermittent access intake escalation 2	2.0	2.3	3.0	-1.4	1.5	1.3	1.7
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.8	-0.2	0.3	0.2	0.9
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.8	-0.3	0.5	-0.0	0.9
Intermitt. access escalation Index	0.9	1.3	2.4	-1.6	1.5	0.6	0.0
Intermittent access day 1 total infusions	0.7	1.1	2.1	-0.2	0.4	-1.5	-1.4
Intermittent access day 15 total infusions	1.1	1.6	3.3	-1.6	1.8	0.3	0.5
Intermittent access terminal intake (last 3 days)	0.7	0.9	2.0	-1.2	1.4	-0.2	0.4
Intermittent access total infusions	0.4	0.5	0.7	-0.5	0.7	-0.8	-0.6
Intermittent access day 1 locomotion	0.3	0.4	1.2	0.0	0.1	-1.1	-0.8
Intermittent access day 15 total locomotion	0.4	0.8	1.9	-1.1	1.4	-0.1	0.1
Intermittent access total locomotion	0.6	0.8	1.7	-1.0	1.3	-0.5	-0.3
Intermittent access standard deviation	0.6	1.2	1.6	-1.0	1.1	0.9	1.2
Left kidney weight	0.6	2.7	4.7	-2.2	2.2	1.1	0.3
Right kidney weight	0.6	2.6	4.0	-1.9	2.0	1.5	0.6
Cocaine induced anxiety	0.1	0.1	0.1	0.4	-0.3	-0.1	0.4
Post-drug Anxiety	0.2	0.2	0.4	0.6	-0.5	-0.3	0.2
Baseline Anxiety	0.0	0.0	0.1	-0.1	-0.0	0.2	0.0
Tail length	0.1	0.4	0.9	0.3	-0.6	0.9	0.5
Length with tail	0.3	1.3	3.1	1.5	-1.8	0.2	-0.0
Length without tail	0.5	1.5	3.6	1.6	-1.9	-0.0	0.1
Times rat made contact with spout	0.9	1.1	1.3	1.0	-1.1	-0.9	-1.1
Lifetime Intake	0.4	0.5	0.8	-0.5	0.6	-0.9	-0.9
Liver weight, left	1.1	1.8	2.2	-1.5	1.3	1.4	1.1
Liver weight, right	0.7	1.3	1.8	-1.3	1.1	1.2	0.7
Locomotor activity	1.2	1.9	3.6	-1.2	0.9	1.9	1.3
Locomotor testing distance	1.3	2.3	4.5	-1.2	0.9	2.1	1.5
Locomotor testing rearing	0.3	0.6	0.9	-0.8	0.7	0.9	0.8
Locomotion in novel chamber	2.0	2.5	3.9	-1.9	2.0	1.3	1.1
Locomotion in novel chamber post-restriction	1.1	1.8	2.8	-1.6	1.7	0.9	1.0
Fecal boli incidents, locomotor time 1	0.4	0.5	1.7	-0.4	0.5	0.2	1.3
Change in fecal boli incidents, locomotor task	0.9	0.8	2.4	0.6	-0.7	-0.5	-1.5
Time >=10cm from walls, locomotor time 1	0.7	0.7	1.6	0.5	-0.3	-1.2	-1.0
Bouts of movement, locomotor time 1	0.4	0.4	0.7	0.9	-0.8	-0.5	-0.2
Total resting periods, locomotor time 1	0.3	0.4	0.6	0.8	-0.7	-0.5	-0.2
Rest time, locomotor task time 1	1.0	1.2	1.8	-0.9	0.9	1.2	1.3
Distance moved, locomotor task time 1	1.0	1.5	2.2	0.9	-0.9	-1.4	-1.5
Vertical activity count, locomotor time 1	0.2	0.4	0.8	-0.9	0.9	0.3	-0.1
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.2	-0.1	-0.1	0.1
Bouts of movement, locomotor time 2	0.2	0.3	0.5	0.6	-0.6	-0.7	-0.1
Total resting periods, locomotor time 2	0.1	0.2	0.5	0.4	-0.4	-0.7	-0.0
Rest time, locomotor task time 2	1.0	1.3	1.6	-1.3	1.2	0.9	1.1
Distance moved, locomotor task time 2	0.6	0.7	0.9	0.9	-0.9	-0.4	-0.9
Vertical activity count, locomotor time 2	0.5	0.7	1.7	-0.8	0.7	1.3	0.5
Light reinforcement 1	0.0	0.1	0.1	-0.2	0.1	0.3	-0.3
Light reinforcement 2	0.4	0.7	1.0	-0.8	1.0	0.7	0.8
Bone: marrow area	0.3	0.6	1.3	-0.2	0.4	-0.9	-1.2
Bone: maximum diameter	0.0	0.0	0.0	0.1	0.1	-0.1	-0.0
Bone: maximum force	2.9	5.2	7.4	2.7	-2.5	-2.2	-1.5
Bone: maximum moment	2.9	5.0	7.0	2.6	-2.5	-2.1	-1.6
Mean time between licks in bursts	0.1	0.2	0.4	0.5	-0.7	0.0	-0.4
Mean num. licks in bursts	0.1	0.1	0.2	-0.5	0.3	0.0	-0.2
Cd content in liver	0.5	0.5	1.2	-0.9	1.1	0.3	0.1
Co content in liver	3.1	3.5	5.6	-1.5	1.1	2.4	2.3
Cu content in liver	0.2	0.3	0.5	0.4	-0.4	-0.6	-0.7
Fe content in liver	0.1	0.1	0.4	-0.0	-0.1	0.4	0.6
K content in liver	1.1	1.0	1.3	1.1	-1.2	-0.9	-0.8
Mg content in liver	0.1	0.1	0.2	0.3	-0.4	-0.4	-0.0
Mn content in liver	1.4	1.6	2.8	1.7	-1.5	-1.2	-0.1
Na content in liver	0.3	0.3	0.7	0.0	0.0	0.8	0.7
Rb content in liver	0.1	0.1	0.2	-0.4	0.2	-0.1	0.3
Se content in liver	0.1	0.1	0.2	-0.2	0.4	-0.3	-0.0
Sr content in liver	0.1	0.1	0.2	0.4	-0.4	0.1	0.0
Zn content in liver	0.1	0.2	0.4	0.2	-0.2	-0.3	-0.6
Bone: minimum diameter	0.7	1.2	2.5	0.5	-0.3	-1.6	-1.4
Time in familiar zone, hab. session 1	0.2	0.2	0.2	0.5	-0.4	-0.5	-0.2
Time in novel zone, hab. session 1	0.6	0.6	0.9	-0.9	0.8	0.9	0.5
Total zone transitions, hab. session 1	0.9	1.3	1.7	1.3	-1.3	-0.9	-1.0
Total locomotion distance, hab. session 1	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.2
Locomotion velocity, hab. session 1	0.1	0.1	0.1	0.2	-0.2	-0.2	-0.4
Time in familiar zone, hab. session 2	0.3	0.3	0.7	-0.1	-0.2	0.6	0.9
Time in novel zone, hab. session 2	0.7	0.7	1.5	0.5	-0.3	-0.9	-1.2
Total zone transitions, hab. session 2	6.2	7.9	8.9	2.7	-2.7	-3.0	-2.9
Total locomotion distance, hab. session 2	1.6	2.1	2.5	1.3	-1.4	-1.6	-1.6
Locomotion velocity, hab. session 2	1.3	1.8	2.3	1.1	-1.1	-1.5	-1.5
Novel to familiar place preference ratio	0.5	0.5	1.1	0.7	-0.4	-1.0	-0.6
Novelty place preference	0.3	0.3	0.9	0.4	-0.1	-0.9	-0.6
Time in novel zone, NPP test	0.3	0.3	0.8	0.4	-0.1	-0.9	-0.6
Total zone transitions, NPP test	2.9	4.3	5.6	2.3	-2.4	-1.7	-1.8
Total locomotion distance, NPP test	0.6	0.8	1.0	0.9	-1.0	-0.6	-0.9
Locomotion velocity, NPP test	0.5	0.7	1.0	0.9	-1.0	-0.6	-0.9
Intraocular pressure	2.1	2.9	3.6	-1.7	1.8	1.4	1.9
Delta distance traveled before/after self-admin	0.4	0.4	0.8	-0.5	0.4	0.7	0.9
Delta ambulatory time before/after self-admin	0.2	0.3	0.6	-0.3	0.2	0.6	0.8
Parametrial fat weight	1.6	3.6	6.8	-2.5	2.6	0.8	0.9
Pavlov. Cond. lever latency	0.1	0.2	0.2	-0.4	0.5	0.4	0.1
Pavlov. Cond. magazine entry latency	1.0	1.3	1.6	1.1	-1.0	-1.3	-1.2
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	0.4	-0.1	-0.7	-0.5
Pavlov. Cond. index score	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.1	0.4	-0.3	-0.4	-0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.1	0.3	-0.3	-0.4	-0.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	-0.5	0.4	0.2	-0.0
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.0	-1.0	1.0	0.7	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	0.6	-0.5	-0.5	-0.5
Pavlov. Cond. response bias	0.1	0.1	0.2	0.4	-0.3	-0.1	-0.1
Pavlov. Cond. lever latency	0.1	0.1	0.3	-0.5	0.5	0.3	-0.1
Pavlov. Cond. magazine entry latency	4.8	5.8	7.8	2.8	-2.7	-2.3	-1.7
Pavlov. Cond. change in total contacts	1.3	2.2	2.8	1.7	-1.5	-1.7	-1.0
Pavlov. Cond. index score	2.0	2.7	3.9	2.0	-1.8	-1.6	-1.1
Pavlov. Cond. latency score	1.7	2.2	3.3	1.8	-1.7	-1.4	-0.9
Pavlov. Cond. lever contacts	0.2	0.2	0.4	0.6	-0.5	-0.5	-0.1
Pavlov. Cond. magazine entry number	5.9	7.3	10.0	-3.2	3.1	2.5	1.9
Pavlov. Cond. intertrial magazine entries	0.5	0.8	1.2	-1.1	1.1	0.8	0.5
Pavlov. Cond. lever-magazine prob. diff.	2.5	3.3	4.7	2.2	-2.0	-1.8	-1.2
Pavlov. Cond. response bias	1.6	2.1	2.9	1.7	-1.6	-1.5	-0.9
Time in closed arm before self-admin	0.1	0.1	0.2	0.4	-0.2	-0.4	-0.0
Time in closed arm after self-admin	0.0	0.0	0.0	0.1	-0.2	0.0	0.1
Time in open arm before self-admin	0.2	0.2	0.6	-0.5	0.2	0.8	-0.3
Time in open arm after self-admin	0.1	0.1	0.2	-0.3	0.2	0.2	0.5
Bone: periosteal estimation	0.1	0.1	0.3	0.1	0.0	-0.5	-0.5
Bone: periosteal perimeter	0.4	0.7	1.1	0.9	-0.6	-1.0	-0.7
Bone: post-yield work	6.6	9.7	15.6	2.3	-1.8	-3.9	-3.8
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	-0.1	0.2	-0.5	-0.5
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.1	0.1	-0.5	-0.5
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	-0.0	0.1	-0.3	-0.1
Progressive ratio test 2 active lever presses	0.3	0.3	0.8	-0.7	0.9	-0.2	0.0
Progressive ratio test 2 breakpoint	0.3	0.3	0.8	-0.7	0.9	-0.1	0.1
Progressive ratio test 2 inactive lever presses	1.4	2.2	4.7	-1.9	2.2	0.5	0.5
Incentive Sensitization - Responses	0.4	0.6	1.1	0.7	-0.5	-1.0	-0.8
Incentive Sensitization - Breakpoint	0.3	0.4	0.8	0.5	-0.4	-0.9	-0.6
Sum of active levers in priming session hrs 5-6	1.0	0.9	2.2	-0.2	0.4	1.2	1.5
Progressive ratio	3.3	5.2	8.0	1.7	-1.7	-2.7	-2.8
Food seeking constrained by brief footshock	0.1	0.2	0.3	0.5	-0.6	-0.1	-0.2
Seeking ratio, punishment vs. effort	2.2	3.1	5.1	-1.4	1.3	2.3	2.0
Retroperitoneal fat weight	3.9	16.7	27.4	-5.1	5.2	2.9	2.3
Reaction time number correct	0.1	0.3	0.6	-0.0	-0.0	0.7	0.7
Reaction time mean minus median	1.0	2.6	4.0	2.0	-1.8	-1.4	-1.1
Reaction time mean minus median AUC	0.3	0.8	1.6	1.3	-1.1	-0.4	-0.3
Reaction time num false alarms	0.6	0.9	1.7	-0.7	0.4	1.3	1.1
Reaction time num false alarms AUC	0.2	0.3	0.7	0.1	-0.3	0.8	0.7
Reaction time trials correct on left	0.1	0.3	0.6	-0.0	-0.0	0.7	0.7
Reaction time trials on left	0.1	0.3	0.6	-0.0	-0.1	0.8	0.7
Reaction time mean	0.1	0.1	0.2	0.4	-0.3	-0.4	-0.5
Reaction time mean AUC	0.1	0.2	0.3	0.4	-0.2	-0.4	-0.6
Median of all reaction times	0.0	0.0	0.1	0.0	0.1	-0.2	-0.3
Reaction time omissions	0.6	0.8	1.4	1.2	-1.1	-0.7	-0.2
Reaction time false alarm rate	0.1	0.2	0.4	-0.2	-0.0	0.6	0.5
Reaction time premature initiation rate	1.2	1.6	3.3	1.6	-1.8	-0.5	-0.7
Reaction time premature initiations	0.9	1.5	3.4	1.6	-1.9	-0.0	-0.2
Std. dev. reaction times	0.5	0.9	1.4	1.2	-1.0	-0.8	-0.7
Reaction time trials completed	0.1	0.3	0.6	-0.0	-0.1	0.8	0.7
Reaction time trials AUC	0.1	0.3	0.6	-0.0	-0.1	0.8	0.7
Run reversals in cocaine runway, females	1.5	1.5	1.8	1.2	-1.2	-1.1	-1.3
Run reversals in cocaine runway, males	2.9	2.9	5.8	-1.0	0.9	2.0	2.4
Latency to leave start box in cocaine runway	0.5	0.5	1.2	0.7	-0.5	-1.1	-0.4
Latency to leave start box in cocaine runway, F	0.3	0.3	0.7	0.4	-0.4	-0.8	-0.5
Latency to leave start box in cocaine runway, M	0.3	0.3	0.5	0.7	-0.6	-0.5	0.1
Std. dev. time between licks in bursts	0.3	0.3	1.1	-0.4	0.1	1.0	0.4
Total sessions with >9 infusions	1.2	1.4	3.1	0.6	-0.6	-1.4	-1.8
Short access day 1 total inactive lever presses	0.9	1.2	2.2	-1.5	1.5	0.6	0.4
Short access day 10 total inactive lever presses	0.1	0.3	1.0	-0.2	0.2	0.3	1.0
Short access day 1 total infusions	0.3	0.4	0.5	-0.7	0.7	-0.6	-0.6
Short access day 10 total infusions	2.3	3.0	5.4	0.8	-0.7	-2.3	-2.3
Short access total infusions	1.0	1.3	3.0	0.3	-0.2	-1.4	-1.7
Short access day 1 locomotion	0.1	0.1	0.4	-0.1	0.1	-0.7	-0.3
Short access day 10 total locomotion	0.1	0.3	0.7	0.2	0.0	-0.8	-0.6
Short access total locomotion	0.2	0.2	0.6	-0.0	0.1	-0.8	-0.6
One hour access (0.3 mA shock)	1.2	1.4	2.5	-1.4	1.6	0.6	0.7
Compulsive drug intake	0.4	0.5	1.1	0.6	-1.0	0.6	0.4
One hour access (shock baseline)	1.3	2.0	4.3	-1.7	2.1	0.4	0.7
Social response proportion	1.3	1.4	2.1	1.5	-1.3	-1.1	-0.9
Social responses	0.2	0.2	0.4	0.6	-0.6	-0.2	-0.1
Social time	0.1	0.1	0.2	0.4	-0.4	0.0	-0.4
Soleus weight	2.8	8.1	11.2	-3.3	3.3	2.6	1.9
Bone: stiffness	2.5	4.1	5.4	2.1	-1.9	-2.3	-1.7
Tibialis anterior weight	2.1	7.1	14.9	3.6	-3.9	-0.8	-0.3
Time to tail flick, vehicle, before self-admin	0.6	0.6	0.9	0.9	-0.9	-0.8	-0.5
Time to tail flick, vehicle, after self-admin	1.9	2.6	4.3	1.2	-1.2	-1.7	-2.1
Time to tail flick, test, before self-admin	0.4	0.4	1.0	0.0	-0.0	-0.8	-1.0
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.1	0.0	-0.1	0.2
Delta time to tail flick, vehicle, before/after SA	1.2	1.1	1.5	1.0	-0.9	-1.1	-1.2
Delta time to tail flick, test, before/after SA	1.0	1.1	2.3	-0.4	0.4	1.3	1.5
Tibia length	0.0	0.0	0.1	0.2	-0.1	0.2	-0.3
Ambulatory time before self-admin	0.5	0.8	1.4	1.0	-0.8	-1.2	-0.5
Ambulatory time after self-admin	0.1	0.1	0.4	0.3	-0.2	-0.7	0.2
Bone: tissue strength	0.2	0.2	0.3	0.3	-0.2	-0.5	-0.6
Total heroin consumption	1.4	1.6	2.0	1.4	-1.4	-1.1	-1.1
Bone: trabecular number	2.9	4.8	7.1	1.7	-1.5	-2.7	-2.6
Bone: trabecular spacing	0.5	0.7	1.2	-0.8	0.6	1.1	0.8
Bone: trabecular thickness	0.7	0.9	1.8	0.2	-0.1	-1.3	-1.3
Bone: trabecular tissue density	3.7	5.4	6.3	-2.4	2.5	2.3	2.1
Water consumed over 24 hours	0.7	0.9	1.2	1.1	-1.1	-0.7	-0.7
Number of responses in last shaping day	0.2	0.2	0.7	-0.2	0.1	0.3	0.8