Hub : Genes

Top6bl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Top6bl 0.03 0.02 2.6e-03 0 0.01 0 0 2.9e-01 6.7e-02 8.3e-02 1.7e-01
2 Adipose gene expression Top6bl 0.07 0.06 1.9e-04 0.02 0.03 0.03 0.02 5.0e-03 4.3e-04 1.2e-04 1.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.91.72.01.2-1.4
Area under the delay curve0.71.11.31.0-1.1
BMI with tail0.41.31.70.9-1.3
BMI without tail0.00.20.30.2-0.5
Body weight0.52.22.8-1.71.3
Weight adjusted by age0.72.02.1-1.51.4
Bone surface0.00.10.1-0.30.1
Bone volume0.20.40.40.5-0.7
Breakpoint value in progressive ratio session0.81.41.6-1.31.1
Number of licking bursts0.00.10.1-0.30.2
Context. condit. distance diff. score1.01.31.31.1-1.1
Locomotion velocity, session 10.30.30.3-0.50.5
Locomotion distance, session 10.30.40.50.5-0.7
Locomotion velocity, session 20.60.81.0-1.00.7
Locomotion distance, session 20.00.00.0-0.0-0.2
Locomotion velocity, session 30.70.80.90.8-0.9
Locomotion distance, session 30.00.00.00.1-0.1
Stereotopy head waving bouts, day 31.61.92.31.3-1.5
Stereotopy head waving duration, day 31.92.32.51.5-1.6
Locomotion velocity, session 70.91.01.11.0-1.0
Locomotion distance, session 70.00.10.10.2-0.3
Stereotopy head waving bouts, day 71.01.11.21.0-1.1
Stereotopy head waving duration, day 70.20.30.40.5-0.6
Locomotion velocity, session 80.91.11.2-1.11.0
Locomotion distance, session 80.40.60.60.8-0.8
Degree of sensitization distance0.20.20.30.4-0.5
Degree of sensitization stereotypy0.00.00.00.1-0.2
Conditioned locomotion2.32.72.8-1.71.6
Cocaine response after cond. corrected0.20.30.30.6-0.6
Cocaine response after cond. not corrected0.30.50.50.7-0.7
Cocaine response before conditioning0.00.00.1-0.20.2
Saline control response0.91.21.6-1.30.9
Bone: connectivity density0.10.20.20.3-0.5
Bone: cortical apparent density0.60.91.0-0.91.0
Bone: cortical area0.81.41.5-1.11.2
Bone: cortical porosity0.30.30.30.5-0.6
Bone: cortical porosity0.00.00.00.1-0.2
Bone: cortical thickness6.010.010.2-3.23.1
Bone: cortical thickness2.12.63.0-1.71.5
Bone: cortical tissue density0.71.21.3-1.01.1
Condit. Reinf. active minus inactive responses0.00.00.00.0-0.0
Condit. Reinf. active-inactive response ratio0.00.00.00.1-0.0
Condit. Reinf. active responses0.00.00.0-0.00.0
Condit. Reinf. inactive responses0.00.00.10.2-0.2
Incentive salience index mean0.00.00.00.0-0.1
Condit. Reinf. lever presses0.10.20.2-0.40.5
Condit. Reinf. active minus inactive responses0.81.31.31.2-1.1
Condit. Reinf. active-inactive response ratio1.11.71.81.4-1.2
Condit. Reinf. active responses1.11.51.61.2-1.3
Condit. Reinf. inactive responses0.20.40.50.5-0.7
Condit. Reinf. lever presses0.10.10.1-0.30.2
Condit. Reinf. lever reinforcers received0.71.01.10.9-1.0
Conditioned reinforcement - actives0.00.10.1-0.20.3
Conditioned reinforcement - inactives0.71.82.11.5-1.2
Conditioned locomotion2.53.74.32.1-1.8
Patch foraging indifference point 0 sec0.20.70.80.8-0.9
Patch foraging indifference point AUC1.22.92.9-1.71.7
Delay disc. indifference point, 0s delay1.92.22.61.3-1.6
Delay disc. indifference point, 16s delay1.11.61.81.4-1.2
Delay disc. indifference point, 2s delay0.70.80.80.9-0.9
Delay disc. indifference point, 24s delay0.00.00.1-0.20.1
Delay disc. indifference point, 4s delay0.70.80.90.8-1.0
Delay disc. indifference point, 8s delay0.40.60.80.6-0.9
Indifference point function ln k1.65.05.02.2-2.2
Indifference point function log k1.65.05.02.2-2.2
Patch foraging total patch changes 0 sec0.00.10.10.2-0.4
Patch foraging total patch changes 12 sec1.21.62.0-1.41.1
Patch foraging total patch changes 18 sec0.00.00.0-0.20.2
Patch foraging total patch changes 24 sec0.62.02.2-1.51.4
Patch foraging total patch changes 6 sec0.10.20.3-0.50.3
Patch foraging time to switch 0 sec0.00.10.10.2-0.3
Patch foraging water rate 0 sec0.00.10.20.4-0.3
Patch foraging water rate 12 sec0.31.31.41.2-1.1
Patch foraging water rate 18 sec0.30.70.70.8-0.8
Patch foraging water rate 24 sec0.10.20.20.5-0.4
Patch foraging water rate 6 sec0.10.10.10.3-0.4
Seeking ratio, delayed vs. immediate footshock0.71.11.11.0-1.0
Distance traveled before self-admin0.00.10.20.2-0.4
Distance traveled after self-admin0.00.00.0-0.1-0.1
Extensor digitorum longus weight4.819.320.6-4.54.2
Bone: elastic displacement0.70.80.9-0.90.9
Bone: elastic work2.83.74.0-2.01.8
Bone: endosteal estimation2.35.75.72.4-2.4
Bone: endosteal perimeter3.48.48.83.0-2.8
Epididymis fat weight1.36.67.82.8-2.3
Delta time in closed arm before/after self-admin0.50.50.7-0.80.5
Delta time in open arm before/after self-admin0.10.10.1-0.20.4
Diff in mean of infusions in LGA sessions0.51.01.0-1.01.0
Delay discount exponential model param0.60.80.9-0.81.0
Extinction: sum of active levers before priming0.20.20.3-0.60.4
Active lever presses in extinction session 61.91.92.1-1.41.3
Bone: final force0.81.41.5-1.21.1
Bone: final moment0.71.21.3-1.11.0
Food consumed during 24 hour testing period0.10.20.2-0.40.5
Glucose4.97.87.92.8-2.8
Heart weight3.25.25.32.3-2.3
Delay discount hyperbolic model param0.70.91.0-0.81.0
Intermittent access intake day 1-15 change0.00.20.30.5-0.3
Intermittent access intake escalation0.00.10.10.3-0.1
Intermittent access intake escalation 20.00.10.10.3-0.1
Intermitt. access day 1 inactive lever presses0.00.00.00.20.1
Intermitt. access day 15 inactive lever presses0.31.51.81.4-1.1
Intermitt. access escalation Index1.13.53.81.9-1.8
Intermittent access day 1 total infusions2.88.48.93.0-2.8
Intermittent access day 15 total infusions2.15.15.92.4-2.1
Intermittent access terminal intake (last 3 days)3.25.66.52.5-2.2
Intermittent access total infusions5.26.16.62.6-2.4
Intermittent access day 1 locomotion2.74.95.42.3-2.1
Intermittent access day 15 total locomotion1.45.36.22.5-2.1
Intermittent access total locomotion8.710.411.63.4-3.1
Intermittent access standard deviation0.10.30.40.6-0.4
Left kidney weight0.32.12.21.5-1.4
Right kidney weight0.00.20.30.5-0.4
Cocaine induced anxiety0.00.00.0-0.10.1
Post-drug Anxiety0.30.30.4-0.60.5
Baseline Anxiety0.20.30.4-0.70.4
Tail length0.84.54.7-2.22.1
Length with tail2.310.010.5-3.23.1
Length without tail1.36.97.6-2.82.5
Times rat made contact with spout0.00.00.0-0.2-0.0
Lifetime Intake3.84.75.02.2-2.1
Liver weight, left0.00.00.00.1-0.1
Liver weight, right0.50.90.91.0-1.0
Locomotor activity0.00.10.10.2-0.3
Locomotor testing distance0.00.10.10.3-0.4
Locomotor testing rearing0.41.61.61.2-1.2
Locomotion in novel chamber3.04.04.42.1-1.9
Locomotion in novel chamber post-restriction0.82.52.71.6-1.5
Fecal boli incidents, locomotor time 10.00.10.2-0.10.4
Change in fecal boli incidents, locomotor task0.30.30.40.4-0.6
Time >=10cm from walls, locomotor time 12.83.54.02.0-1.8
Bouts of movement, locomotor time 11.11.41.7-1.01.3
Total resting periods, locomotor time 10.60.70.9-0.71.0
Rest time, locomotor task time 10.30.50.60.8-0.6
Distance moved, locomotor task time 10.10.40.60.5-0.7
Vertical activity count, locomotor time 10.00.30.30.6-0.6
Time >=10cm from walls, locomotor time 20.00.00.00.2-0.1
Bouts of movement, locomotor time 20.10.30.4-0.40.6
Total resting periods, locomotor time 20.00.00.1-0.10.3
Rest time, locomotor task time 20.81.31.51.2-1.1
Distance moved, locomotor task time 20.70.91.1-1.10.8
Vertical activity count, locomotor time 20.71.51.7-1.31.2
Light reinforcement 10.00.10.10.2-0.3
Light reinforcement 20.20.40.60.8-0.5
Bone: marrow area2.56.06.02.5-2.4
Bone: maximum diameter0.00.00.1-0.00.3
Bone: maximum force0.20.40.4-0.60.6
Bone: maximum moment0.20.30.3-0.60.5
Mean time between licks in bursts0.10.30.4-0.60.5
Mean num. licks in bursts0.10.20.30.4-0.5
Cd content in liver1.21.31.31.2-1.1
Co content in liver0.20.30.3-0.60.5
Cu content in liver0.30.30.40.5-0.6
Fe content in liver0.40.50.6-0.80.7
K content in liver0.00.00.0-0.1-0.1
Mg content in liver0.80.90.90.9-1.0
Mn content in liver1.82.12.2-1.41.5
Na content in liver1.01.21.2-1.01.1
Rb content in liver2.32.62.81.6-1.7
Se content in liver0.30.30.40.6-0.5
Sr content in liver3.53.13.2-1.71.8
Zn content in liver0.10.10.1-0.30.2
Bone: minimum diameter3.36.36.42.5-2.5
Time in familiar zone, hab. session 10.70.80.80.9-0.9
Time in novel zone, hab. session 10.10.10.2-0.40.4
Total zone transitions, hab. session 10.10.20.2-0.50.4
Total locomotion distance, hab. session 10.40.60.70.7-0.8
Locomotion velocity, hab. session 10.10.20.20.3-0.4
Time in familiar zone, hab. session 20.40.50.5-0.70.7
Time in novel zone, hab. session 20.60.60.70.7-0.8
Total zone transitions, hab. session 21.21.62.01.1-1.4
Total locomotion distance, hab. session 21.72.32.61.4-1.6
Locomotion velocity, hab. session 22.02.73.01.5-1.7
Novel to familiar place preference ratio0.00.00.0-0.00.1
Novelty place preference0.00.10.10.3-0.2
Time in novel zone, NPP test0.10.10.10.3-0.3
Total zone transitions, NPP test0.10.10.1-0.40.1
Total locomotion distance, NPP test0.30.40.60.4-0.7
Locomotion velocity, NPP test0.20.20.30.3-0.6
Intraocular pressure0.00.10.10.00.3
Delta distance traveled before/after self-admin0.10.10.1-0.40.3
Delta ambulatory time before/after self-admin0.10.20.2-0.50.3
Parametrial fat weight2.76.46.92.6-2.5
Pavlov. Cond. lever latency0.00.00.00.2-0.1
Pavlov. Cond. magazine entry latency0.40.50.50.7-0.7
Pavlov. Cond. change in total contacts0.10.10.20.4-0.3
Pavlov. Cond. index score0.00.00.0-0.10.1
Pavlov. Cond. latency score0.00.00.00.1-0.2
Pavlov. Cond. lever contacts0.00.00.00.1-0.2
Pavlov. Cond. magazine entry number0.10.10.10.3-0.4
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.00.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.10.1
Pavlov. Cond. response bias0.10.10.1-0.30.3
Pavlov. Cond. lever latency0.30.40.40.6-0.7
Pavlov. Cond. magazine entry latency0.50.70.8-0.90.8
Pavlov. Cond. change in total contacts0.00.00.0-0.20.2
Pavlov. Cond. index score0.30.50.5-0.70.7
Pavlov. Cond. latency score0.30.50.6-0.70.8
Pavlov. Cond. lever contacts0.20.30.3-0.50.5
Pavlov. Cond. magazine entry number1.21.61.81.3-1.2
Pavlov. Cond. intertrial magazine entries0.20.50.70.8-0.6
Pavlov. Cond. lever-magazine prob. diff.0.40.60.7-0.80.8
Pavlov. Cond. response bias0.20.30.4-0.60.5
Time in closed arm before self-admin0.71.11.41.2-0.9
Time in closed arm after self-admin0.10.10.10.3-0.3
Time in open arm before self-admin0.10.10.2-0.50.2
Time in open arm after self-admin0.20.20.2-0.50.4
Bone: periosteal estimation0.20.40.40.7-0.6
Bone: periosteal perimeter0.20.50.50.7-0.6
Bone: post-yield work3.56.06.32.5-2.4
Progressive ratio test 1 active lever presses0.20.30.30.6-0.5
Progressive ratio test 1 breakpoint0.10.20.30.5-0.5
Progressive ratio test 1 inactive lever presses0.00.10.10.3-0.3
Progressive ratio test 2 active lever presses1.92.72.91.7-1.6
Progressive ratio test 2 breakpoint1.92.42.61.6-1.5
Progressive ratio test 2 inactive lever presses2.68.39.33.1-2.7
Incentive Sensitization - Responses0.20.60.60.8-0.8
Incentive Sensitization - Breakpoint0.30.80.80.9-0.9
Sum of active levers in priming session hrs 5-64.64.34.6-2.02.1
Progressive ratio0.41.21.41.0-1.2
Food seeking constrained by brief footshock0.10.10.2-0.40.3
Seeking ratio, punishment vs. effort0.10.30.3-0.50.6
Retroperitoneal fat weight5.323.725.85.1-4.6
Reaction time number correct0.31.01.1-1.00.9
Reaction time mean minus median0.32.12.3-1.41.5
Reaction time mean minus median AUC0.42.83.1-1.61.8
Reaction time num false alarms0.20.30.4-0.60.4
Reaction time num false alarms AUC0.40.91.1-1.10.8
Reaction time trials correct on left0.31.01.1-1.00.9
Reaction time trials on left0.41.31.4-1.21.1
Reaction time mean0.00.00.00.00.1
Reaction time mean AUC0.00.00.00.20.0
Median of all reaction times0.20.30.30.6-0.5
Reaction time omissions1.32.12.1-1.51.5
Reaction time false alarm rate0.10.10.1-0.40.2
Reaction time premature initiation rate1.62.42.9-1.71.4
Reaction time premature initiations1.85.46.2-2.52.2
Std. dev. reaction times0.20.70.8-0.70.9
Reaction time trials completed0.41.31.4-1.21.1
Reaction time trials AUC0.20.81.0-1.00.8
Run reversals in cocaine runway, females0.00.00.10.1-0.3
Run reversals in cocaine runway, males1.41.61.6-1.21.3
Latency to leave start box in cocaine runway0.71.01.11.0-1.0
Latency to leave start box in cocaine runway, F0.50.60.60.8-0.8
Latency to leave start box in cocaine runway, M0.00.00.00.2-0.1
Std. dev. time between licks in bursts0.20.50.7-0.80.5
Total sessions with >9 infusions0.60.80.80.9-0.9
Short access day 1 total inactive lever presses1.02.12.21.5-1.4
Short access day 10 total inactive lever presses0.00.00.10.2-0.1
Short access day 1 total infusions1.63.23.51.9-1.7
Short access day 10 total infusions2.74.54.52.1-2.1
Short access total infusions1.62.32.31.5-1.5
Short access day 1 locomotion1.32.12.51.6-1.3
Short access day 10 total locomotion0.62.52.81.7-1.5
Short access total locomotion1.92.83.11.8-1.6
One hour access (0.3 mA shock)3.94.65.32.3-2.0
Compulsive drug intake2.53.84.5-2.11.7
One hour access (shock baseline)2.66.98.22.9-2.4
Social response proportion0.00.00.0-0.10.1
Social responses0.20.30.3-0.60.5
Social time0.40.60.6-0.80.7
Soleus weight1.23.63.71.9-1.9
Bone: stiffness0.00.00.0-0.00.1
Tibialis anterior weight9.934.135.4-5.95.7
Time to tail flick, vehicle, before self-admin0.10.10.10.2-0.3
Time to tail flick, vehicle, after self-admin0.20.30.40.5-0.6
Time to tail flick, test, before self-admin3.23.63.71.9-1.9
Time to tail flick, test, after self-admin0.00.00.1-0.10.2
Delta time to tail flick, vehicle, before/after SA0.00.00.00.1-0.2
Delta time to tail flick, test, before/after SA4.96.06.6-2.32.6
Tibia length1.33.54.0-1.82.0
Ambulatory time before self-admin0.10.20.20.4-0.5
Ambulatory time after self-admin0.81.31.41.1-1.2
Bone: tissue strength0.10.10.20.4-0.4
Total heroin consumption2.12.53.0-1.71.4
Bone: trabecular number0.50.91.00.9-1.0
Bone: trabecular spacing0.00.00.0-0.1-0.0
Bone: trabecular thickness1.72.42.41.6-1.6
Bone: trabecular tissue density0.40.70.91.0-0.6
Water consumed over 24 hours0.20.30.5-0.70.5
Number of responses in last shaping day0.00.10.1-0.30.2