Hub : Genes

Top6bl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Top6bl 0.16 0.1 2.1e-03 0.05 0.13 0.02 0.07 3.1e-02 6.8e-04 8.7e-02 1.0e-02
2 Liver gene expression Top6bl 0.03 0.02 2.4e-03 0 0.01 0 0 8.9e-02 5.2e-02 1.7e-01 1.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.71.12.1-0.41.5
Area under the delay curve0.90.91.2-0.81.1
BMI with tail0.20.80.91.00.8
BMI without tail0.10.20.30.50.3
Body weight1.98.011.63.4-2.1
Weight adjusted by age2.62.93.61.9-1.5
Bone surface0.50.91.81.40.1
Bone volume0.20.40.70.30.9
Breakpoint value in progressive ratio session2.52.73.61.9-1.3
Number of licking bursts0.10.10.20.4-0.2
Context. condit. distance diff. score1.51.82.4-1.51.1
Locomotion velocity, session 10.10.20.20.2-0.5
Locomotion distance, session 10.10.20.40.00.6
Locomotion velocity, session 21.41.62.41.5-0.9
Locomotion distance, session 20.10.20.30.6-0.0
Locomotion velocity, session 30.40.40.5-0.50.7
Locomotion distance, session 30.00.00.0-0.10.1
Stereotopy head waving bouts, day 31.21.41.4-1.21.2
Stereotopy head waving duration, day 31.61.92.0-1.41.4
Locomotion velocity, session 70.91.01.2-0.91.1
Locomotion distance, session 70.00.00.0-0.10.2
Stereotopy head waving bouts, day 70.91.11.3-0.91.2
Stereotopy head waving duration, day 70.10.20.30.20.5
Locomotion velocity, session 81.21.41.51.2-1.1
Locomotion distance, session 80.40.50.5-0.70.7
Degree of sensitization distance0.10.10.2-0.20.4
Degree of sensitization stereotypy0.10.10.10.20.3
Conditioned locomotion3.03.53.61.9-1.9
Cocaine response after cond. corrected0.60.60.9-1.00.6
Cocaine response after cond. not corrected0.70.81.0-1.00.8
Cocaine response before conditioning0.10.10.20.5-0.0
Saline control response1.82.43.61.9-1.1
Bone: connectivity density0.30.40.40.70.6
Bone: cortical apparent density0.40.50.50.7-0.7
Bone: cortical area1.11.71.81.3-1.2
Bone: cortical porosity0.20.20.4-0.20.6
Bone: cortical porosity0.00.10.10.30.1
Bone: cortical thickness6.210.210.33.2-3.2
Bone: cortical thickness3.03.53.91.7-2.0
Bone: cortical tissue density0.60.70.70.8-0.9
Condit. Reinf. active minus inactive responses0.00.00.00.20.2
Condit. Reinf. active-inactive response ratio0.00.00.1-0.00.2
Condit. Reinf. active responses0.00.00.00.20.0
Condit. Reinf. inactive responses0.00.00.0-0.10.2
Incentive salience index mean0.00.00.10.30.1
Condit. Reinf. lever presses0.20.20.30.6-0.4
Condit. Reinf. active minus inactive responses1.01.21.5-0.91.2
Condit. Reinf. active-inactive response ratio1.51.51.6-1.21.3
Condit. Reinf. active responses0.81.11.7-0.71.3
Condit. Reinf. inactive responses0.20.30.5-0.00.7
Condit. Reinf. lever presses0.70.91.61.3-0.4
Condit. Reinf. lever reinforcers received0.40.61.0-0.31.0
Conditioned reinforcement - actives0.00.00.1-0.30.0
Conditioned reinforcement - inactives4.14.76.1-2.51.8
Conditioned locomotion3.94.77.1-2.71.5
Patch foraging indifference point 0 sec0.20.30.4-0.50.6
Patch foraging indifference point AUC3.03.54.42.1-1.6
Delay disc. indifference point, 0s delay1.41.51.6-1.21.3
Delay disc. indifference point, 16s delay2.12.22.3-1.41.5
Delay disc. indifference point, 2s delay0.40.40.5-0.60.7
Delay disc. indifference point, 24s delay0.00.00.0-0.0-0.2
Delay disc. indifference point, 4s delay0.50.60.6-0.70.8
Delay disc. indifference point, 8s delay0.30.30.4-0.50.7
Indifference point function ln k4.76.69.5-3.11.9
Indifference point function log k4.76.69.5-3.11.9
Patch foraging total patch changes 0 sec0.00.00.0-0.10.1
Patch foraging total patch changes 12 sec2.53.34.82.2-1.3
Patch foraging total patch changes 18 sec0.10.20.30.6-0.1
Patch foraging total patch changes 24 sec2.32.83.41.8-1.5
Patch foraging total patch changes 6 sec0.40.51.01.0-0.3
Patch foraging time to switch 0 sec0.20.40.70.80.3
Patch foraging water rate 0 sec0.81.32.6-1.60.3
Patch foraging water rate 12 sec2.23.46.3-2.50.8
Patch foraging water rate 18 sec1.21.62.6-1.60.7
Patch foraging water rate 24 sec1.01.42.6-1.60.4
Patch foraging water rate 6 sec0.60.81.6-1.30.0
Seeking ratio, delayed vs. immediate footshock0.40.50.7-0.50.9
Distance traveled before self-admin0.10.10.20.5-0.3
Distance traveled after self-admin0.00.10.10.3-0.2
Extensor digitorum longus weight5.923.129.95.5-4.1
Bone: elastic displacement0.30.40.80.1-0.9
Bone: elastic work2.53.33.71.7-1.9
Bone: endosteal estimation2.45.25.6-2.22.4
Bone: endosteal perimeter3.87.98.8-2.63.0
Epididymis fat weight2.96.88.1-2.92.4
Delta time in closed arm before/after self-admin0.50.50.60.6-0.8
Delta time in open arm before/after self-admin0.00.00.00.1-0.1
Diff in mean of infusions in LGA sessions0.80.91.01.0-0.9
Delay discount exponential model param0.60.60.80.7-0.9
Extinction: sum of active levers before priming2.12.13.21.8-1.0
Active lever presses in extinction session 63.63.53.71.9-1.8
Bone: final force1.52.43.41.8-1.2
Bone: final moment1.32.02.91.7-1.1
Food consumed during 24 hour testing period0.10.10.20.3-0.4
Glucose4.06.06.3-2.42.5
Heart weight3.04.25.0-2.21.9
Delay discount hyperbolic model param0.50.50.70.6-0.8
Intermittent access intake day 1-15 change0.10.10.1-0.1-0.3
Intermittent access intake escalation0.00.00.1-0.30.0
Intermittent access intake escalation 20.20.20.30.1-0.5
Intermitt. access day 1 inactive lever presses1.92.02.4-1.51.3
Intermitt. access day 15 inactive lever presses1.41.51.9-1.41.1
Intermitt. access escalation Index5.14.55.1-2.32.0
Intermittent access day 1 total infusions10.211.912.5-3.33.5
Intermittent access day 15 total infusions7.78.79.8-3.12.8
Intermittent access terminal intake (last 3 days)6.47.07.4-2.72.6
Intermittent access total infusions7.17.98.2-2.72.9
Intermittent access day 1 locomotion7.57.88.7-2.63.0
Intermittent access day 15 total locomotion5.35.76.1-2.52.3
Intermittent access total locomotion10.512.012.4-3.43.5
Intermittent access standard deviation0.30.30.5-0.70.3
Left kidney weight0.20.50.9-0.90.3
Right kidney weight0.00.10.2-0.1-0.4
Cocaine induced anxiety0.10.10.10.2-0.3
Post-drug Anxiety2.22.52.51.6-1.5
Baseline Anxiety2.83.03.41.8-1.6
Tail length2.06.27.22.3-2.7
Length with tail3.412.313.13.6-3.4
Length without tail2.45.26.52.5-2.0
Times rat made contact with spout0.10.10.20.4-0.0
Lifetime Intake6.57.47.9-2.62.8
Liver weight, left0.00.00.0-0.2-0.1
Liver weight, right0.00.00.0-0.1-0.1
Locomotor activity0.20.40.7-0.90.0
Locomotor testing distance0.40.71.3-1.10.2
Locomotor testing rearing1.32.12.8-1.71.2
Locomotion in novel chamber3.64.55.8-2.41.8
Locomotion in novel chamber post-restriction2.12.53.3-1.81.3
Fecal boli incidents, locomotor time 10.00.00.00.1-0.1
Change in fecal boli incidents, locomotor task0.10.10.1-0.20.4
Time >=10cm from walls, locomotor time 13.33.44.2-1.62.0
Bouts of movement, locomotor time 10.91.01.31.2-0.8
Total resting periods, locomotor time 10.40.50.70.8-0.5
Rest time, locomotor task time 10.60.61.0-1.00.5
Distance moved, locomotor task time 10.10.20.3-0.10.6
Vertical activity count, locomotor time 10.60.60.8-0.90.6
Time >=10cm from walls, locomotor time 20.10.10.1-0.20.3
Bouts of movement, locomotor time 20.30.30.50.7-0.4
Total resting periods, locomotor time 20.10.10.20.4-0.1
Rest time, locomotor task time 21.82.02.7-1.61.2
Distance moved, locomotor task time 21.01.21.51.2-0.9
Vertical activity count, locomotor time 21.11.21.70.8-1.3
Light reinforcement 10.10.10.2-0.50.2
Light reinforcement 20.50.71.0-1.00.6
Bone: marrow area2.55.45.7-2.22.4
Bone: maximum diameter0.00.10.10.3-0.2
Bone: maximum force0.71.12.21.5-0.3
Bone: maximum moment0.61.01.81.4-0.3
Mean time between licks in bursts0.40.50.50.7-0.7
Mean num. licks in bursts0.20.20.2-0.50.5
Cd content in liver0.50.50.9-1.00.4
Co content in liver0.20.20.2-0.4-0.4
Cu content in liver0.10.10.20.4-0.1
Fe content in liver0.20.20.20.5-0.5
K content in liver0.30.30.60.80.1
Mg content in liver1.41.52.4-0.71.6
Mn content in liver1.51.72.51.6-0.9
Na content in liver1.31.41.41.2-1.2
Rb content in liver3.13.84.0-1.92.0
Se content in liver0.40.50.8-0.40.9
Sr content in liver4.23.84.02.0-1.9
Zn content in liver0.70.71.11.0-0.6
Bone: minimum diameter2.75.05.9-2.02.4
Time in familiar zone, hab. session 10.80.70.8-0.80.9
Time in novel zone, hab. session 10.10.10.20.1-0.5
Total zone transitions, hab. session 10.30.50.70.9-0.5
Total locomotion distance, hab. session 10.40.50.6-0.80.7
Locomotion velocity, hab. session 10.10.10.1-0.30.3
Time in familiar zone, hab. session 20.30.40.50.4-0.7
Time in novel zone, hab. session 20.40.40.6-0.40.8
Total zone transitions, hab. session 20.50.71.4-0.01.2
Total locomotion distance, hab. session 21.01.31.9-0.91.4
Locomotion velocity, hab. session 21.31.72.3-1.11.5
Novel to familiar place preference ratio0.10.10.20.50.1
Novelty place preference0.10.10.20.10.4
Time in novel zone, NPP test0.10.10.2-0.00.4
Total zone transitions, NPP test0.40.61.11.0-0.3
Total locomotion distance, NPP test0.10.10.2-0.20.4
Locomotion velocity, NPP test0.00.00.1-0.10.3
Intraocular pressure0.10.10.2-0.5-0.1
Delta distance traveled before/after self-admin0.00.00.00.0-0.1
Delta ambulatory time before/after self-admin0.00.00.10.1-0.2
Parametrial fat weight3.36.57.1-2.72.4
Pavlov. Cond. lever latency0.00.00.1-0.30.1
Pavlov. Cond. magazine entry latency0.40.60.9-0.51.0
Pavlov. Cond. change in total contacts0.20.20.3-0.30.6
Pavlov. Cond. index score0.00.00.00.00.1
Pavlov. Cond. latency score0.00.00.1-0.10.2
Pavlov. Cond. lever contacts0.00.00.0-0.00.1
Pavlov. Cond. magazine entry number0.10.10.1-0.30.2
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.2-0.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.2-0.0
Pavlov. Cond. response bias0.00.00.00.2-0.1
Pavlov. Cond. lever latency0.20.20.4-0.60.3
Pavlov. Cond. magazine entry latency1.21.42.41.6-0.6
Pavlov. Cond. change in total contacts0.30.40.90.9-0.0
Pavlov. Cond. index score0.81.01.81.3-0.5
Pavlov. Cond. latency score0.70.91.51.2-0.5
Pavlov. Cond. lever contacts0.40.50.70.8-0.6
Pavlov. Cond. magazine entry number2.42.94.8-2.21.0
Pavlov. Cond. intertrial magazine entries0.70.91.3-1.10.7
Pavlov. Cond. lever-magazine prob. diff.1.01.32.21.5-0.6
Pavlov. Cond. response bias0.70.91.61.2-0.6
Time in closed arm before self-admin0.10.20.2-0.30.5
Time in closed arm after self-admin0.00.00.0-0.00.0
Time in open arm before self-admin0.10.10.1-0.30.1
Time in open arm after self-admin0.00.00.1-0.1-0.2
Bone: periosteal estimation0.10.20.3-0.40.5
Bone: periosteal perimeter0.10.20.4-0.20.6
Bone: post-yield work3.75.08.1-1.42.8
Progressive ratio test 1 active lever presses2.62.83.1-1.81.6
Progressive ratio test 1 breakpoint2.02.12.5-1.61.3
Progressive ratio test 1 inactive lever presses1.41.61.6-1.31.2
Progressive ratio test 2 active lever presses4.14.44.9-2.22.0
Progressive ratio test 2 breakpoint3.84.35.2-2.31.8
Progressive ratio test 2 inactive lever presses9.611.112.4-3.53.1
Incentive Sensitization - Responses0.70.70.8-0.70.9
Incentive Sensitization - Breakpoint0.80.80.8-0.90.9
Sum of active levers in priming session hrs 5-63.83.74.01.8-2.0
Progressive ratio0.30.30.40.40.7
Food seeking constrained by brief footshock0.40.50.50.7-0.7
Seeking ratio, punishment vs. effort0.20.20.3-0.4-0.5
Retroperitoneal fat weight5.016.620.2-4.53.6
Reaction time number correct0.91.31.41.0-1.2
Reaction time mean minus median1.72.23.21.8-1.1
Reaction time mean minus median AUC2.02.63.11.8-1.5
Reaction time num false alarms0.20.30.60.2-0.8
Reaction time num false alarms AUC0.81.11.40.9-1.2
Reaction time trials correct on left0.91.31.41.0-1.2
Reaction time trials on left1.11.61.81.2-1.3
Reaction time mean0.00.00.00.00.1
Reaction time mean AUC0.00.00.1-0.10.2
Median of all reaction times0.20.20.2-0.40.5
Reaction time omissions1.62.22.71.6-1.3
Reaction time false alarm rate0.10.10.20.1-0.5
Reaction time premature initiation rate2.43.23.71.9-1.7
Reaction time premature initiations4.96.97.32.7-2.5
Std. dev. reaction times0.50.60.91.0-0.6
Reaction time trials completed1.11.61.81.2-1.3
Reaction time trials AUC0.81.11.30.9-1.1
Run reversals in cocaine runway, females0.10.10.10.20.3
Run reversals in cocaine runway, males1.31.22.00.7-1.4
Latency to leave start box in cocaine runway0.60.60.9-0.61.0
Latency to leave start box in cocaine runway, F0.20.30.4-0.30.6
Latency to leave start box in cocaine runway, M0.00.00.0-0.10.2
Std. dev. time between licks in bursts0.30.40.70.4-0.8
Total sessions with >9 infusions2.52.72.8-1.61.7
Short access day 1 total inactive lever presses4.24.75.5-2.32.0
Short access day 10 total inactive lever presses1.82.02.7-1.71.1
Short access day 1 total infusions6.36.77.1-2.52.7
Short access day 10 total infusions5.76.38.1-2.12.8
Short access total infusions3.53.94.6-1.82.1
Short access day 1 locomotion4.65.05.6-2.12.4
Short access day 10 total locomotion3.64.14.7-1.92.2
Short access total locomotion3.53.64.3-1.72.1
One hour access (0.3 mA shock)7.89.110.9-3.32.7
Compulsive drug intake3.94.04.22.0-1.9
One hour access (shock baseline)8.09.310.9-3.32.8
Social response proportion0.10.10.30.50.0
Social responses0.30.40.40.7-0.5
Social time0.40.50.60.8-0.7
Soleus weight2.26.49.5-3.11.8
Bone: stiffness0.30.51.01.00.1
Tibialis anterior weight11.539.545.96.8-5.8
Time to tail flick, vehicle, before self-admin0.10.10.10.30.1
Time to tail flick, vehicle, after self-admin0.40.50.80.9-0.3
Time to tail flick, test, before self-admin1.61.51.8-1.11.4
Time to tail flick, test, after self-admin0.00.00.00.2-0.2
Delta time to tail flick, vehicle, before/after SA0.10.10.20.5-0.1
Delta time to tail flick, test, before/after SA3.73.43.91.7-2.0
Tibia length1.23.53.71.9-1.8
Ambulatory time before self-admin0.10.10.10.3-0.1
Ambulatory time after self-admin0.70.70.9-0.71.0
Bone: tissue strength0.10.10.2-0.20.4
Total heroin consumption4.04.76.12.5-1.8
Bone: trabecular number0.40.71.3-0.11.2
Bone: trabecular spacing0.00.00.0-0.2-0.2
Bone: trabecular thickness1.82.12.6-1.21.6
Bone: trabecular tissue density1.52.13.3-1.80.9
Water consumed over 24 hours0.40.40.70.8-0.5
Number of responses in last shaping day0.50.50.7-0.90.4