Hub : Genes

Doc2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	IL	gene expression	Doc2b	0.25	0.14	1.3e-04	0	0.08	0.04	0.08	3.2e-01	7.0e-03	4.0e-02	4.9e-03
2	NAcc	gene expression	Doc2b	0.43	0.12	0.0e+00	0.41	0.41	0.41	0.42	6.2e-68	5.6e-68	5.7e-68	2.1e-68
3	OFC	gene expression	Doc2b	0.41	0.24	6.6e-03	0.08	0.07	0.08	0.07	6.1e-03	7.6e-03	6.8e-03	9.9e-03
4	pVTA	gene expression	Doc2b	0.17	0.15	6.9e-05	0.05	0.03	0.06	0.01	3.3e-05	3.5e-03	1.9e-05	9.5e-02
5	PL	gene expression	Doc2b	0.25	0.12	0.0e+00	0.18	0.15	0.17	0.17	5.7e-19	2.0e-16	4.4e-18	1.4e-18
6	IC	gene expression	Doc2b	0.4	0.14	3.2e-11	0.24	0.14	0.26	0.01	1.4e-10	2.0e-06	3.0e-11	1.2e-01
7	Brain	mRNA stability	Doc2b	0.54	0.13	0.0e+00	0.38	0.38	0.38	0.35	5.9e-37	1.8e-37	8.2e-38	1.7e-33
8	Brain	intron excision ratio	chr10_61131293_61135052	0.15	0.1	9.2e-08	0.07	0.06	0.06	0.09	1.6e-07	2.1e-06	5.8e-06	2.5e-08
9	NAcc	mRNA stability	Doc2b	0.05	0.03	1.1e-04	0.03	0.03	0.03	0.03	7.6e-05	4.3e-05	4.0e-05	5.8e-05
10	Brain	gene expression	Doc2b	0.74	0.03	0.0e+00	0.5	0.52	0.54	0.34	7.7e-54	3.6e-56	6.0e-59	2.5e-32
11	BLA	mRNA stability	Doc2b	0.24	0.15	1.4e-06	0.12	0.08	0.08	0.1	5.7e-07	5.7e-05	3.4e-05	6.8e-06
12	Eye	intron excision ratio	chr10_61140951_61141521	0.22	0.15	4.7e-03	0.16	0.18	0.07	0.14	2.2e-03	9.9e-04	3.5e-02	3.1e-03
13	Adipose	gene expression	Doc2b	0.12	0.07	4.7e-09	0.05	0.07	0.08	0.07	1.4e-06	1.1e-08	4.9e-09	2.0e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bone: apparent density	4.6	7.9	9.7	3.1	3.0	3.0	2.9	2.9	2.9	-2.8	-2.8	-3.0	2.7	-2.7	-2.6	2.1
Area under the delay curve	1.5	1.8	2.5	-1.3	-1.3	-1.4	-1.2	-1.3	-1.3	1.5	1.6	1.0	-1.5	1.6	1.1	-0.9
BMI with tail	1.1	3.9	5.2	2.0	2.1	1.9	2.1	2.1	2.1	-2.2	-2.1	-2.0	1.9	-2.3	-1.6	1.1
BMI without tail	0.7	2.3	6.1	1.9	1.2	0.8	1.1	1.1	1.1	-1.2	-1.1	-1.9	0.8	-1.3	-2.4	2.5
Body weight	0.8	3.7	14.4	2.5	1.1	0.7	1.0	1.0	0.9	-0.9	-0.8	-2.6	0.3	-0.7	-3.7	3.8
Weight adjusted by age	0.4	0.7	0.9	0.7	0.9	0.9	1.0	0.9	0.9	-1.0	-1.0	-0.4	1.0	-0.9	-0.2	0.0
Bone surface	4.2	7.6	9.2	2.9	3.0	3.0	3.0	2.9	2.9	-2.9	-2.8	-2.8	2.6	-2.7	-2.2	1.6
Bone volume	4.3	7.6	9.2	3.0	3.0	3.0	3.0	3.0	3.0	-2.9	-2.8	-2.7	2.6	-2.7	-2.3	1.5
Breakpoint value in progressive ratio session	0.7	0.9	2.3	1.2	0.8	0.7	0.7	0.7	0.7	-0.7	-0.6	-1.1	0.5	-0.6	-1.5	1.5
Number of licking bursts	0.5	0.8	1.6	-0.8	-0.7	-0.8	-0.7	-0.7	-0.9	1.1	1.2	1.0	-1.2	1.3	0.5	-0.6
Context. condit. distance diff. score	1.3	1.6	2.1	1.4	1.2	1.3	1.2	1.2	1.3	-1.3	-1.3	-1.3	1.3	-1.3	-1.4	0.9
Locomotion velocity, session 1	2.7	2.9	4.7	2.1	1.6	1.5	1.5	1.6	1.5	-1.5	-1.4	-2.1	1.4	-1.3	-2.2	1.9
Locomotion distance, session 1	0.7	0.9	1.4	1.0	1.1	1.2	1.2	1.1	1.1	-0.8	-0.7	-1.1	0.8	-0.4	-0.6	0.3
Locomotion velocity, session 2	0.8	0.9	1.6	1.2	1.1	1.0	1.0	1.1	1.0	-0.9	-0.8	-1.3	0.8	-0.6	-0.8	0.6
Locomotion distance, session 2	1.8	2.5	3.4	1.7	1.8	1.8	1.8	1.8	1.8	-1.5	-1.5	-1.8	1.5	-1.1	-1.1	0.9
Locomotion velocity, session 3	5.9	6.7	8.7	-2.6	-2.7	-2.7	-2.6	-2.7	-2.7	2.9	2.9	2.3	-2.9	2.9	1.8	-1.3
Locomotion distance, session 3	0.1	0.1	0.3	-0.2	0.1	0.1	0.1	0.1	0.1	0.1	0.2	-0.2	-0.1	0.3	0.5	-0.5
Stereotopy head waving bouts, day 3	0.2	0.2	0.5	-0.1	-0.4	-0.6	-0.4	-0.3	-0.4	0.5	0.5	-0.1	-0.6	0.7	-0.5	0.7
Stereotopy head waving duration, day 3	0.3	0.4	1.2	-0.5	-0.3	-0.5	-0.4	-0.2	-0.5	0.6	0.8	0.6	-0.8	1.1	0.4	-0.6
Locomotion velocity, session 7	1.2	1.3	1.7	1.0	1.3	1.2	1.3	1.3	1.3	-1.3	-1.3	-1.1	1.3	-1.2	-0.5	0.3
Locomotion distance, session 7	1.9	2.4	3.4	1.4	1.6	1.6	1.7	1.6	1.7	-1.8	-1.8	-1.5	1.8	-1.8	-0.9	0.5
Stereotopy head waving bouts, day 7	0.7	0.7	1.4	1.2	1.0	0.9	0.9	1.0	0.8	-0.5	-0.3	-1.1	0.3	0.1	-1.2	1.0
Stereotopy head waving duration, day 7	1.0	1.2	2.0	1.4	1.3	1.2	1.3	1.4	1.2	-0.8	-0.6	-1.3	0.6	-0.2	-1.2	0.9
Locomotion velocity, session 8	0.5	0.6	1.0	0.9	0.9	1.0	1.0	0.9	0.9	-0.8	-0.8	-0.6	0.9	-0.7	-0.3	-0.1
Locomotion distance, session 8	2.1	3.1	4.7	2.2	1.9	1.8	1.9	1.8	1.8	-1.6	-1.5	-2.2	1.5	-1.2	-1.9	1.4
Degree of sensitization distance	1.3	1.3	2.3	1.2	0.9	0.8	0.9	0.9	1.0	-1.2	-1.3	-1.0	1.2	-1.5	-1.3	1.2
Degree of sensitization stereotypy	1.0	1.1	2.1	1.4	1.2	1.1	1.1	1.2	1.0	-0.7	-0.6	-1.3	0.6	-0.3	-1.4	1.1
Conditioned locomotion	0.2	0.2	0.8	-0.7	-0.4	-0.3	-0.4	-0.4	-0.3	0.2	0.2	0.9	-0.1	-0.2	0.7	-0.6
Cocaine response after cond. corrected	0.1	0.1	0.6	0.2	-0.1	-0.1	-0.1	-0.2	-0.1	-0.0	-0.1	-0.3	0.1	-0.1	-0.7	0.8
Cocaine response after cond. not corrected	0.2	0.3	0.9	0.6	0.3	0.3	0.3	0.2	0.3	-0.3	-0.4	-0.6	0.3	-0.4	-1.0	0.9
Cocaine response before conditioning	1.0	1.2	1.7	1.3	1.3	1.2	1.3	1.3	1.2	-1.1	-1.0	-1.2	0.8	-1.0	-0.9	0.5
Saline control response	0.3	0.5	0.9	0.7	0.9	0.9	1.0	1.0	0.8	-0.6	-0.5	-0.4	0.5	-0.2	-0.2	-0.2
Bone: connectivity density	6.8	10.6	12.5	3.5	3.5	3.5	3.5	3.4	3.4	-3.3	-3.3	-3.5	3.1	-3.0	-2.7	2.2
Bone: cortical apparent density	0.2	0.3	1.4	-0.7	-0.3	-0.1	-0.3	-0.2	-0.2	0.3	0.3	0.8	-0.1	0.3	1.1	-1.2
Bone: cortical area	1.9	2.9	3.8	-1.9	-1.9	-1.9	-1.9	-1.9	-1.8	1.7	1.6	1.7	-1.6	1.5	1.5	-1.0
Bone: cortical porosity	0.1	0.1	0.2	0.5	0.3	0.3	0.3	0.3	0.3	-0.3	-0.2	-0.4	0.2	-0.2	-0.5	0.3
Bone: cortical porosity	0.0	0.0	0.0	-0.0	-0.1	-0.2	-0.2	-0.1	-0.2	0.1	0.2	0.2	-0.2	0.2	-0.1	-0.0
Bone: cortical thickness	6.6	10.9	13.2	-3.4	-3.6	-3.6	-3.6	-3.6	-3.6	3.6	3.6	2.9	-3.4	3.4	2.3	-1.5
Bone: cortical thickness	1.6	1.9	2.7	-1.2	-1.6	-1.6	-1.6	-1.7	-1.6	1.6	1.5	0.8	-1.5	1.5	0.4	-0.1
Bone: cortical tissue density	0.1	0.2	1.0	-0.5	-0.1	0.1	-0.1	-0.1	-0.1	0.2	0.2	0.6	0.0	0.2	0.9	-1.0
Condit. Reinf. active minus inactive responses	0.3	0.4	0.7	-0.5	-0.7	-0.8	-0.8	-0.6	-0.8	0.7	0.7	0.5	-0.8	0.5	0.0	0.3
Condit. Reinf. active-inactive response ratio	3.1	3.3	4.7	-1.6	-2.1	-2.1	-2.2	-2.0	-2.1	2.0	2.0	1.3	-2.2	1.8	0.3	0.4
Condit. Reinf. active responses	0.2	0.3	0.6	0.5	0.6	0.5	0.5	0.6	0.5	-0.7	-0.7	-0.3	0.6	-0.8	-0.4	0.4
Condit. Reinf. inactive responses	4.0	4.9	7.5	1.8	2.5	2.5	2.5	2.5	2.5	-2.6	-2.7	-1.2	2.7	-2.5	-0.4	-0.3
Incentive salience index mean	0.2	0.2	0.4	-0.2	-0.5	-0.6	-0.6	-0.4	-0.6	0.5	0.6	0.0	-0.6	0.5	-0.3	0.5
Condit. Reinf. lever presses	0.3	0.4	1.4	0.8	0.2	0.1	0.2	0.3	0.2	-0.2	-0.2	-1.0	0.2	-0.3	-1.2	1.2
Condit. Reinf. active minus inactive responses	0.4	0.6	1.1	0.8	0.8	0.8	0.8	0.8	0.8	-0.8	-0.7	-0.6	0.7	-1.0	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.1	-0.4	-0.4	-0.4	-0.4	-0.4	0.2	0.2	0.3	-0.3	-0.3	-0.2	0.4
Condit. Reinf. active responses	1.0	1.4	2.5	1.2	1.5	1.3	1.5	1.6	1.4	-1.3	-1.1	-0.9	1.0	-1.2	-0.3	0.0
Condit. Reinf. inactive responses	2.4	3.1	5.9	1.5	2.3	2.1	2.4	2.4	2.1	-1.8	-1.6	-1.2	1.7	-1.3	-0.0	-0.7
Condit. Reinf. lever presses	0.3	0.4	2.4	-0.4	0.2	0.1	0.2	0.2	0.1	-0.1	0.1	0.9	-0.1	-0.1	1.2	-1.6
Condit. Reinf. lever reinforcers received	0.9	1.2	2.4	1.1	1.4	1.2	1.5	1.6	1.3	-1.2	-1.0	-0.8	0.9	-1.0	-0.1	-0.1
Conditioned reinforcement - actives	1.6	2.7	3.7	1.6	1.8	1.9	1.8	1.8	1.8	-1.9	-1.8	-1.2	1.9	-1.9	-0.8	0.4
Conditioned reinforcement - inactives	0.3	0.4	0.6	0.6	0.7	0.7	0.7	0.7	0.7	-0.7	-0.7	-0.7	0.8	-0.7	-0.4	0.2
Conditioned locomotion	0.2	0.3	1.1	-0.6	-0.3	-0.2	-0.2	-0.2	-0.3	0.4	0.5	0.7	-0.4	0.3	1.0	-1.0
Patch foraging indifference point 0 sec	0.2	0.4	0.6	0.5	0.7	0.7	0.7	0.7	0.7	-0.7	-0.7	-0.5	0.7	-0.7	-0.2	-0.0
Patch foraging indifference point AUC	0.1	0.1	0.7	-0.4	-0.0	-0.1	-0.0	0.0	-0.0	0.1	0.0	0.2	0.1	0.2	0.8	-0.8
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	0.4	0.4	-0.1	0.4	0.5	0.3	-0.1	-0.0	-0.3	-0.1	0.0	-0.4	0.5
Delay disc. indifference point, 16s delay	1.5	1.6	2.6	-1.3	-1.2	-1.3	-1.1	-1.2	-1.2	1.4	1.5	1.0	-1.4	1.6	1.1	-1.0
Delay disc. indifference point, 2s delay	0.9	1.0	1.5	-1.0	-1.0	-0.9	-0.9	-1.0	-1.0	1.2	1.2	0.7	-1.2	1.1	0.9	-0.8
Delay disc. indifference point, 24s delay	0.3	0.3	0.5	-0.6	-0.6	-0.6	-0.5	-0.5	-0.5	0.6	0.7	0.5	-0.6	0.5	0.6	-0.5
Delay disc. indifference point, 4s delay	1.1	1.2	1.9	-0.9	-1.1	-1.2	-1.1	-1.1	-1.2	1.3	1.3	0.7	-1.4	1.3	0.5	-0.3
Delay disc. indifference point, 8s delay	0.9	1.0	1.4	-1.0	-1.1	-1.1	-1.0	-1.0	-1.1	1.1	1.1	0.7	-1.1	1.2	0.7	-0.7
Indifference point function ln k	0.5	0.9	1.3	1.1	1.0	1.0	1.0	1.0	1.0	-0.9	-0.9	-1.0	0.9	-0.8	-0.9	0.6
Indifference point function log k	0.5	0.9	1.3	1.1	1.0	1.0	1.0	1.0	1.0	-0.9	-0.9	-1.0	0.9	-0.8	-0.9	0.6
Patch foraging total patch changes 0 sec	0.3	0.5	0.8	0.6	0.8	0.9	0.8	0.8	0.8	-0.9	-0.9	-0.5	0.9	-0.9	-0.2	-0.1
Patch foraging total patch changes 12 sec	0.3	0.4	0.6	-0.7	-0.7	-0.8	-0.8	-0.7	-0.8	0.6	0.6	0.5	-0.6	0.6	0.5	-0.2
Patch foraging total patch changes 18 sec	0.7	1.0	2.3	-0.8	-0.9	-1.1	-1.0	-0.9	-1.1	1.2	1.3	0.6	-1.3	1.5	0.4	-0.2
Patch foraging total patch changes 24 sec	0.4	0.6	0.8	-0.9	-0.8	-0.7	-0.8	-0.8	-0.8	0.9	0.9	0.7	-0.8	0.9	0.8	-0.5
Patch foraging total patch changes 6 sec	0.1	0.2	1.3	-0.4	0.2	0.2	0.2	0.2	0.1	-0.2	-0.1	0.5	0.2	-0.1	0.8	-1.1
Patch foraging time to switch 0 sec	0.9	1.9	3.0	-0.9	-1.6	-1.7	-1.6	-1.5	-1.6	1.5	1.5	1.2	-1.7	1.3	-0.1	0.4
Patch foraging water rate 0 sec	0.3	0.6	1.1	0.3	0.9	1.0	1.0	0.9	0.9	-0.8	-0.8	-0.3	1.0	-0.7	0.5	-0.7
Patch foraging water rate 12 sec	0.0	0.0	0.0	0.1	0.1	0.2	0.1	0.1	0.1	0.1	0.2	-0.1	-0.1	0.2	-0.1	0.0
Patch foraging water rate 18 sec	2.3	3.5	5.4	2.0	2.2	2.3	2.2	2.1	2.1	-1.9	-1.8	-1.7	1.9	-1.5	-1.4	0.8
Patch foraging water rate 24 sec	0.2	0.2	0.5	0.3	0.6	0.6	0.7	0.7	0.6	-0.4	-0.3	-0.3	0.5	-0.1	0.2	-0.5
Patch foraging water rate 6 sec	0.2	0.3	1.0	-0.7	-0.3	-0.3	-0.3	-0.3	-0.3	0.4	0.5	0.5	-0.3	0.5	1.0	-0.8
Seeking ratio, delayed vs. immediate footshock	0.9	1.1	2.4	-1.2	-0.8	-0.9	-0.7	-0.7	-0.8	0.9	0.9	1.5	-0.9	1.0	1.5	-1.6
Distance traveled before self-admin	3.4	4.4	5.4	-2.3	-2.1	-2.0	-2.0	-2.1	-2.1	2.2	2.2	2.1	-2.1	2.3	2.1	-1.7
Distance traveled after self-admin	0.4	0.5	0.7	-0.8	-0.8	-0.8	-0.8	-0.7	-0.8	0.8	0.8	0.6	-0.8	0.8	0.6	-0.4
Extensor digitorum longus weight	5.7	22.4	29.0	4.8	5.4	5.2	5.4	5.4	5.3	-5.0	-4.8	-4.6	4.9	-4.3	-3.0	2.2
Bone: elastic displacement	0.5	0.6	1.6	-0.8	-0.5	-0.6	-0.5	-0.5	-0.5	0.7	0.8	0.7	-0.5	0.8	1.1	-1.3
Bone: elastic work	5.4	7.0	8.7	-2.8	-2.8	-2.8	-2.7	-2.8	-2.8	2.9	2.9	2.1	-2.7	2.9	2.1	-1.6
Bone: endosteal estimation	0.2	0.5	1.1	0.6	0.7	0.7	0.7	0.7	0.8	-0.9	-0.9	-0.4	0.7	-1.0	-0.2	0.1
Bone: endosteal perimeter	1.2	2.5	4.7	1.2	1.7	1.7	1.7	1.7	1.8	-2.0	-2.0	-0.8	1.9	-2.2	-0.3	0.1
Epididymis fat weight	6.9	23.7	34.9	5.9	4.9	4.8	4.8	4.8	4.7	-4.6	-4.5	-5.3	4.1	-4.3	-5.6	4.7
Delta time in closed arm before/after self-admin	0.5	0.4	1.2	-0.7	-0.4	-0.3	-0.4	-0.3	-0.4	0.5	0.6	0.9	-0.4	0.6	1.1	-1.1
Delta time in open arm before/after self-admin	0.7	0.7	1.7	1.1	0.8	0.8	0.8	0.8	0.8	-0.7	-0.7	-1.3	0.6	-0.6	-1.1	0.8
Diff in mean of infusions in LGA sessions	0.9	1.1	2.0	1.3	0.9	0.9	0.8	0.9	0.9	-1.0	-1.1	-1.0	1.0	-1.1	-1.4	1.4
Delay discount exponential model param	1.4	1.5	2.1	1.2	1.2	1.3	1.2	1.2	1.3	-1.4	-1.4	-0.9	1.4	-1.5	-1.0	0.8
Extinction: sum of active levers before priming	2.6	2.8	3.9	1.7	1.9	1.9	1.9	2.0	1.9	-1.8	-1.7	-1.6	1.8	-1.6	-1.0	0.5
Active lever presses in extinction session 6	2.4	2.4	2.9	1.6	1.7	1.6	1.7	1.7	1.7	-1.6	-1.6	-1.5	1.6	-1.5	-1.2	0.9
Bone: final force	1.1	1.8	2.7	-1.2	-1.6	-1.5	-1.5	-1.6	-1.5	1.5	1.4	0.7	-1.6	1.4	0.3	0.4
Bone: final moment	0.9	1.4	2.1	-1.1	-1.4	-1.3	-1.4	-1.4	-1.4	1.3	1.3	0.6	-1.4	1.3	0.4	0.2
Food consumed during 24 hour testing period	0.2	0.3	0.4	0.6	0.5	0.4	0.5	0.6	0.6	-0.6	-0.7	-0.6	0.6	-0.6	-0.5	0.4
Glucose	4.1	6.4	8.0	-2.8	-2.6	-2.6	-2.6	-2.6	-2.6	2.6	2.6	2.6	-2.5	2.6	2.4	-1.9
Heart weight	1.1	1.7	4.9	1.5	1.1	1.1	1.0	1.0	1.0	-1.0	-1.0	-1.8	0.8	-0.8	-1.9	2.2
Delay discount hyperbolic model param	1.6	1.8	2.6	1.3	1.4	1.4	1.3	1.4	1.4	-1.5	-1.6	-0.9	1.6	-1.6	-1.0	0.7
Intermittent access intake day 1-15 change	0.1	0.3	1.3	-0.5	0.0	0.1	0.1	0.0	0.1	-0.2	-0.2	0.6	0.4	-0.2	1.1	-1.1
Intermittent access intake escalation	0.1	0.3	1.4	-0.5	0.1	0.2	0.1	0.1	0.1	-0.2	-0.3	0.6	0.4	-0.2	1.2	-1.2
Intermittent access intake escalation 2	0.3	0.4	1.7	-0.8	-0.2	-0.0	-0.1	-0.2	-0.1	0.0	-0.1	0.8	0.2	-0.1	1.3	-1.3
Intermitt. access day 1 inactive lever presses	0.5	1.8	4.6	-1.8	-1.2	-1.1	-1.1	-1.1	-1.1	1.0	0.9	1.6	-0.7	0.9	2.1	-1.9
Intermitt. access day 15 inactive lever presses	0.7	1.4	4.7	-1.4	-0.8	-0.8	-0.7	-0.7	-0.7	0.6	0.6	1.6	-0.4	0.6	2.1	-2.2
Intermitt. access escalation Index	0.4	0.6	4.1	0.5	-0.2	-0.4	-0.3	-0.3	-0.3	0.2	0.1	-0.5	-0.3	0.2	-1.5	2.0
Intermittent access day 1 total infusions	0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.0	0.0	-0.1	0.1	0.3	0.3	-0.2	0.1	0.1	-0.4
Intermittent access day 15 total infusions	0.3	0.4	0.5	0.2	0.6	0.7	0.7	0.7	0.7	-0.7	-0.7	0.1	0.7	-0.7	0.5	-0.7
Intermittent access terminal intake (last 3 days)	0.7	0.9	1.5	0.8	1.1	1.1	1.1	1.1	1.1	-1.1	-1.1	-0.5	1.2	-1.2	-0.2	-0.1
Intermittent access total infusions	0.1	0.2	0.4	0.1	0.4	0.4	0.4	0.4	0.4	-0.4	-0.3	0.1	0.4	-0.5	0.4	-0.6
Intermittent access day 1 locomotion	0.5	0.6	1.2	-0.6	-0.7	-0.7	-0.7	-0.7	-0.7	0.9	1.1	0.7	-1.0	0.9	0.5	-0.5
Intermittent access day 15 total locomotion	0.1	0.2	0.7	-0.6	-0.3	-0.5	-0.3	-0.3	-0.3	0.4	0.5	0.5	-0.4	0.6	0.8	-0.7
Intermittent access total locomotion	0.1	0.1	0.4	-0.3	-0.1	-0.2	-0.0	-0.0	-0.1	0.2	0.3	0.2	-0.2	0.3	0.6	-0.6
Intermittent access standard deviation	0.4	0.9	3.0	-0.2	0.7	0.9	0.8	0.8	0.8	-0.8	-0.8	0.2	1.1	-0.9	1.3	-1.7
Left kidney weight	2.1	9.8	14.8	-2.6	-3.4	-3.7	-3.4	-3.4	-3.5	3.6	3.6	2.0	-3.8	3.9	0.7	0.2
Right kidney weight	1.7	7.9	12.2	-2.0	-3.1	-3.2	-3.1	-3.1	-3.2	3.3	3.3	1.4	-3.5	3.5	0.1	0.8
Cocaine induced anxiety	0.0	0.1	0.4	-0.3	-0.1	-0.1	-0.1	-0.1	-0.1	0.2	0.3	-0.0	-0.2	0.1	0.5	-0.6
Post-drug Anxiety	0.3	0.3	1.1	0.7	0.3	0.3	0.3	0.2	0.3	-0.2	-0.0	-1.0	0.1	-0.2	-1.0	0.9
Baseline Anxiety	0.7	0.8	2.3	1.2	0.7	0.7	0.6	0.6	0.7	-0.6	-0.7	-1.1	0.6	-0.5	-1.5	1.5
Tail length	0.6	2.1	12.3	1.1	-0.4	-0.7	-0.6	-0.5	-0.6	0.7	0.7	-1.4	-1.1	1.0	-2.8	3.5
Length with tail	0.7	2.9	12.3	0.7	-0.9	-1.2	-1.1	-1.1	-1.2	1.4	1.4	-1.2	-1.7	1.7	-2.8	3.5
Length without tail	0.2	0.8	3.6	1.0	0.1	0.0	0.1	0.1	-0.0	0.2	0.3	-1.1	-0.4	0.6	-1.9	1.8
Times rat made contact with spout	1.8	2.0	3.0	-1.2	-1.6	-1.7	-1.6	-1.5	-1.6	1.6	1.6	0.9	-1.7	1.7	0.4	0.1
Lifetime Intake	0.1	0.2	0.4	0.1	0.3	0.4	0.4	0.4	0.4	-0.4	-0.3	0.2	0.4	-0.5	0.4	-0.7
Liver weight, left	1.9	3.2	14.8	2.2	0.6	0.4	0.4	0.5	0.5	-0.6	-0.6	-2.4	0.3	-0.7	-3.7	3.8
Liver weight, right	1.6	2.8	11.3	2.1	0.9	0.7	0.7	0.7	0.7	-0.8	-0.8	-2.2	0.5	-0.9	-3.3	3.4
Locomotor activity	0.0	0.1	0.1	0.3	0.3	0.3	0.3	0.3	0.3	-0.2	-0.2	-0.2	0.1	-0.1	-0.3	0.2
Locomotor testing distance	0.0	0.0	0.1	0.3	0.3	0.2	0.3	0.3	0.2	-0.1	-0.1	-0.1	0.1	0.2	-0.2	0.1
Locomotor testing rearing	0.3	0.6	1.3	0.8	1.0	1.1	1.1	1.0	0.9	-0.8	-0.8	-0.4	0.8	-0.5	-0.2	-0.3
Locomotion in novel chamber	1.2	1.5	7.8	-1.4	-0.3	-0.2	-0.2	-0.2	-0.3	0.3	0.3	1.6	-0.0	0.4	2.5	-2.8
Locomotion in novel chamber post-restriction	0.3	0.5	0.8	0.4	0.8	0.8	0.8	0.8	0.8	-0.8	-0.8	-0.6	0.9	-0.7	0.1	-0.4
Fecal boli incidents, locomotor time 1	0.0	0.0	0.2	-0.1	-0.1	0.1	-0.1	-0.1	-0.1	0.2	0.0	-0.4	-0.1	0.2	-0.3	0.3
Change in fecal boli incidents, locomotor task	0.5	0.5	0.8	-0.7	-0.8	-0.9	-0.9	-0.9	-0.8	0.6	0.7	0.9	-0.7	0.2	0.2	0.0
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.6	0.4	0.5	0.3	0.6	0.5	0.6	-0.7	-0.6	-0.7	0.7	-0.7	-0.0	-0.1
Bouts of movement, locomotor time 1	0.1	0.1	0.3	0.2	0.2	0.1	0.2	0.2	0.3	-0.4	-0.5	-0.4	0.4	-0.4	-0.1	-0.0
Total resting periods, locomotor time 1	0.2	0.2	0.6	0.2	0.3	0.2	0.3	0.3	0.4	-0.6	-0.7	-0.3	0.6	-0.7	-0.0	-0.2
Rest time, locomotor task time 1	0.2	0.2	1.1	-0.6	-0.2	-0.4	-0.2	-0.2	-0.2	-0.1	-0.1	0.6	0.1	-0.4	0.8	-1.0
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.4	0.3	0.4	0.3	0.2	0.3	-0.2	-0.2	-0.4	0.3	-0.1	-0.2	0.2
Vertical activity count, locomotor time 1	0.4	0.9	1.3	1.0	1.1	1.1	1.1	1.0	1.0	-0.9	-0.8	-0.9	0.9	-0.8	-0.6	0.6
Time >=10cm from walls, locomotor time 2	0.4	0.6	1.0	-1.0	-0.9	-1.0	-0.9	-0.9	-0.8	0.7	0.7	0.8	-0.7	0.4	0.8	-0.5
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.2	-0.4	-0.0	-0.4	-0.4	-0.3	0.2	0.2	0.5	-0.2	0.2	0.1	-0.2
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.2	0.0	0.3	0.0	-0.0	0.0	-0.1	-0.2	0.2	0.1	-0.1	-0.2	0.0
Rest time, locomotor task time 2	0.2	0.3	0.7	0.5	0.6	0.4	0.5	0.5	0.6	-0.7	-0.7	-0.1	0.8	-0.8	-0.3	-0.1
Distance moved, locomotor task time 2	0.2	0.2	0.9	-0.3	-0.1	-0.3	-0.1	-0.1	-0.1	0.3	0.4	0.3	-0.4	0.4	0.8	-0.9
Vertical activity count, locomotor time 2	0.3	0.3	0.6	-0.6	-0.6	-0.7	-0.6	-0.5	-0.6	0.6	0.7	0.5	-0.8	0.6	0.4	-0.3
Light reinforcement 1	0.0	0.0	0.1	0.3	0.3	0.1	0.2	0.4	0.1	-0.1	0.0	0.2	-0.1	0.0	-0.1	-0.1
Light reinforcement 2	2.4	3.7	5.0	-1.8	-2.0	-2.1	-2.0	-1.9	-2.1	2.1	2.2	1.9	-2.2	2.1	1.1	-0.6
Bone: marrow area	0.2	0.5	1.0	0.6	0.7	0.7	0.7	0.7	0.7	-0.9	-0.9	-0.4	0.7	-1.0	-0.2	0.1
Bone: maximum diameter	0.2	0.3	0.9	-0.1	0.3	0.4	0.3	0.3	0.4	-0.6	-0.7	0.3	0.7	-0.9	0.7	-0.6
Bone: maximum force	1.2	2.1	3.1	-1.3	-1.7	-1.6	-1.7	-1.7	-1.7	1.7	1.6	0.9	-1.7	1.6	0.5	0.1
Bone: maximum moment	1.0	1.7	2.4	-1.3	-1.5	-1.4	-1.5	-1.5	-1.5	1.5	1.4	0.9	-1.5	1.4	0.6	-0.1
Mean time between licks in bursts	0.1	0.3	1.4	0.5	-0.1	-0.2	-0.1	-0.2	-0.2	0.4	0.4	-0.8	-0.4	0.7	-1.0	1.2
Mean num. licks in bursts	0.1	0.1	0.5	-0.1	-0.4	-0.4	-0.4	-0.4	-0.3	0.1	-0.1	-0.3	0.0	-0.2	-0.2	0.7
Cd content in liver	1.0	1.1	1.7	0.9	1.2	1.1	1.2	1.2	1.2	-1.2	-1.2	-0.5	1.3	-1.2	-0.2	-0.2
Co content in liver	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.3	-0.3	-0.3	0.3	0.4	0.2	-0.3	0.4	0.3	-0.3
Cu content in liver	0.8	0.9	1.4	-1.1	-1.1	-1.1	-1.1	-1.1	-1.0	0.9	0.8	1.2	-0.9	0.6	0.9	-0.6
Fe content in liver	0.1	0.2	0.8	0.4	-0.1	-0.2	-0.2	-0.1	-0.1	0.0	0.0	-0.2	-0.2	-0.2	-0.9	0.9
K content in liver	0.6	0.5	1.3	-0.2	-0.7	-0.7	-0.7	-0.7	-0.8	0.8	0.7	0.1	-0.9	0.9	-0.5	1.1
Mg content in liver	0.2	0.2	0.3	0.3	0.5	0.4	0.5	0.5	0.4	-0.5	-0.6	-0.1	0.4	-0.4	0.0	0.1
Mn content in liver	0.8	0.9	1.4	0.6	1.0	1.0	1.0	1.0	1.0	-1.1	-1.2	-0.5	1.2	-1.2	-0.0	-0.2
Na content in liver	3.2	3.4	4.5	-1.8	-2.0	-2.0	-2.0	-2.0	-2.1	2.0	2.0	1.5	-2.1	2.1	1.0	-0.7
Rb content in liver	4.4	5.1	7.2	2.1	2.4	2.4	2.4	2.4	2.5	-2.6	-2.7	-1.7	2.5	-2.6	-1.2	0.9
Se content in liver	0.6	0.7	1.1	-0.9	-0.9	-1.1	-0.9	-0.9	-0.9	0.9	0.9	0.7	-0.9	0.9	0.6	-0.4
Sr content in liver	1.9	1.6	2.5	1.1	1.3	1.4	1.3	1.3	1.4	-1.5	-1.5	-1.0	1.6	-1.6	-0.5	-0.0
Zn content in liver	0.1	0.2	0.6	0.5	0.2	0.1	0.1	0.1	0.2	-0.3	-0.3	-0.6	0.3	-0.3	-0.8	0.7
Bone: minimum diameter	0.8	1.5	2.3	-1.2	-1.5	-1.5	-1.5	-1.5	-1.4	1.3	1.2	1.2	-1.4	1.0	0.5	-0.1
Time in familiar zone, hab. session 1	1.7	1.6	3.2	0.8	1.4	1.8	1.5	1.4	1.5	-1.4	-1.4	-0.8	1.6	-1.2	0.1	-0.6
Time in novel zone, hab. session 1	1.6	1.6	3.4	-0.8	-1.3	-1.8	-1.4	-1.3	-1.4	1.4	1.4	0.8	-1.6	1.3	-0.0	0.4
Total zone transitions, hab. session 1	1.7	2.4	4.2	1.4	2.0	2.0	2.0	2.0	1.8	-1.6	-1.5	-1.0	1.4	-1.2	-0.3	-0.2
Total locomotion distance, hab. session 1	0.6	0.8	1.4	1.0	1.2	1.1	1.2	1.2	1.0	-0.8	-0.7	-0.9	0.7	-0.4	-0.6	0.3
Locomotion velocity, hab. session 1	0.7	1.0	1.8	1.0	1.3	1.3	1.3	1.2	1.1	-1.0	-0.9	-0.9	0.8	-0.7	-0.5	0.1
Time in familiar zone, hab. session 2	1.8	1.9	3.0	1.4	1.7	1.7	1.7	1.7	1.6	-1.3	-1.2	-1.4	1.3	-0.8	-0.8	0.2
Time in novel zone, hab. session 2	4.8	4.9	7.2	-2.2	-2.6	-2.7	-2.6	-2.6	-2.5	2.2	2.2	2.1	-2.3	1.7	1.4	-0.5
Total zone transitions, hab. session 2	0.8	1.1	1.8	1.3	1.3	1.2	1.3	1.4	1.1	-0.9	-0.8	-1.0	0.7	-0.5	-0.9	0.6
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.4	0.3	0.3	0.3	0.3	0.2	-0.1	-0.1	-0.4	-0.0	0.1	-0.5	0.4
Locomotion velocity, hab. session 2	0.0	0.1	0.1	0.3	0.3	0.2	0.3	0.2	0.2	-0.1	-0.0	-0.3	-0.0	0.1	-0.4	0.3
Novel to familiar place preference ratio	0.2	0.2	0.5	-0.4	-0.0	0.0	0.0	-0.1	0.1	-0.4	-0.5	0.6	0.5	-0.7	0.7	-0.7
Novelty place preference	0.1	0.1	0.5	-0.2	-0.1	-0.1	0.0	-0.1	0.1	-0.3	-0.4	0.4	0.4	-0.7	0.4	-0.3
Time in novel zone, NPP test	0.1	0.1	0.7	0.0	0.2	0.2	0.2	0.1	0.3	-0.5	-0.6	0.1	0.5	-0.8	0.1	-0.1
Total zone transitions, NPP test	1.0	1.4	2.7	1.3	1.6	1.6	1.7	1.6	1.4	-1.0	-0.9	-1.1	0.9	-0.3	-0.5	0.1
Total locomotion distance, NPP test	0.2	0.3	0.7	0.4	0.8	0.8	0.8	0.8	0.6	-0.2	-0.2	-0.4	0.2	0.4	0.1	-0.5
Locomotion velocity, NPP test	0.1	0.2	1.1	-0.0	0.4	0.4	0.5	0.4	0.3	0.0	0.1	0.1	0.0	0.5	0.7	-1.1
Intraocular pressure	0.4	0.6	1.8	-0.1	0.7	0.7	0.7	0.7	0.7	-0.6	-0.5	0.7	0.7	-0.7	1.1	-1.3
Delta distance traveled before/after self-admin	2.2	2.3	3.0	1.7	1.4	1.3	1.4	1.4	1.4	-1.6	-1.5	-1.7	1.4	-1.6	-1.6	1.5
Delta ambulatory time before/after self-admin	1.8	2.2	2.7	1.6	1.4	1.3	1.3	1.4	1.4	-1.6	-1.6	-1.7	1.5	-1.6	-1.5	1.4
Parametrial fat weight	6.8	15.9	23.5	4.9	4.0	3.6	3.8	3.9	3.8	-3.8	-3.7	-4.4	3.3	-3.6	-4.8	4.0
Pavlov. Cond. lever latency	0.2	0.3	0.7	0.3	0.7	0.9	0.7	0.6	0.7	-0.5	-0.5	-0.3	0.7	-0.2	0.2	-0.4
Pavlov. Cond. magazine entry latency	0.2	0.3	1.3	0.4	-0.0	-0.1	-0.1	-0.0	0.1	-0.4	-0.5	-0.3	0.3	-0.9	-0.9	1.1
Pavlov. Cond. change in total contacts	0.9	0.9	1.5	-0.9	-1.0	-1.2	-1.1	-1.0	-1.1	1.0	1.0	1.0	-1.1	0.8	0.6	-0.4
Pavlov. Cond. index score	0.1	0.2	0.9	0.3	-0.1	-0.3	-0.2	-0.1	-0.1	-0.1	-0.2	-0.2	-0.1	-0.5	-0.8	1.0
Pavlov. Cond. latency score	0.2	0.2	1.2	0.2	-0.4	-0.6	-0.5	-0.4	-0.4	0.1	0.1	-0.2	-0.3	-0.3	-0.9	1.1
Pavlov. Cond. lever contacts	0.2	0.2	0.6	-0.2	-0.6	-0.8	-0.7	-0.6	-0.6	0.4	0.4	0.3	-0.6	0.1	-0.2	0.3
Pavlov. Cond. magazine entry number	0.1	0.2	0.7	-0.3	-0.1	-0.1	-0.0	-0.1	-0.2	0.5	0.5	0.1	-0.4	0.8	0.5	-0.6
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	0.3	0.8	0.9	0.9	0.9	0.7	-0.5	-0.5	0.1	0.5	-0.1	0.4	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.7	0.3	-0.1	-0.2	-0.2	-0.1	-0.1	-0.2	-0.2	-0.2	0.0	-0.6	-0.7	0.8
Pavlov. Cond. response bias	0.2	0.2	0.7	0.4	0.1	-0.0	-0.0	0.1	0.1	-0.4	-0.4	-0.2	0.3	-0.8	-0.7	0.8
Pavlov. Cond. lever latency	1.4	2.0	3.0	1.4	1.2	1.3	1.2	1.2	1.3	-1.4	-1.4	-1.7	1.4	-1.4	-1.6	1.6
Pavlov. Cond. magazine entry latency	1.8	2.2	3.4	-1.3	-1.6	-1.5	-1.5	-1.6	-1.6	1.7	1.8	1.3	-1.8	1.7	0.7	-0.3
Pavlov. Cond. change in total contacts	1.1	1.7	2.3	-1.3	-1.3	-1.3	-1.2	-1.3	-1.3	1.4	1.5	1.3	-1.5	1.4	1.2	-0.8
Pavlov. Cond. index score	2.1	2.9	3.8	-1.7	-1.6	-1.6	-1.5	-1.5	-1.6	1.7	1.8	2.0	-1.8	1.8	1.7	-1.5
Pavlov. Cond. latency score	2.4	3.2	4.2	-1.8	-1.6	-1.6	-1.6	-1.6	-1.7	1.8	1.9	2.1	-1.9	1.9	1.8	-1.6
Pavlov. Cond. lever contacts	0.9	1.3	1.9	-1.0	-1.1	-1.1	-1.0	-1.0	-1.1	1.2	1.3	1.4	-1.3	1.2	1.0	-1.0
Pavlov. Cond. magazine entry number	1.9	2.4	3.4	1.5	1.6	1.6	1.5	1.6	1.7	-1.8	-1.8	-1.3	1.8	-1.8	-0.9	0.4
Pavlov. Cond. intertrial magazine entries	2.3	3.4	4.5	1.9	2.1	2.0	2.0	2.1	2.0	-2.0	-1.9	-1.8	2.0	-1.8	-1.3	0.7
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.6	3.5	-1.7	-1.5	-1.5	-1.5	-1.5	-1.6	1.7	1.7	1.9	-1.7	1.7	1.6	-1.5
Pavlov. Cond. response bias	1.6	2.1	2.9	-1.4	-1.5	-1.5	-1.4	-1.5	-1.5	1.6	1.7	1.6	-1.7	1.5	1.1	-1.0
Time in closed arm before self-admin	1.2	1.5	3.5	1.5	1.0	0.9	1.0	0.9	1.0	-1.0	-1.1	-1.5	0.9	-1.0	-1.9	1.8
Time in closed arm after self-admin	0.5	0.5	0.6	-0.7	-0.8	-0.8	-0.8	-0.8	-0.8	0.8	0.7	0.7	-0.7	0.7	0.4	-0.2
Time in open arm before self-admin	3.8	4.1	6.4	-2.3	-2.0	-2.0	-2.0	-1.9	-2.0	1.9	2.0	2.5	-1.8	1.9	2.1	-1.9
Time in open arm after self-admin	0.5	0.6	1.3	-0.9	-0.6	-0.7	-0.6	-0.6	-0.6	0.6	0.6	0.8	-0.5	0.8	1.1	-1.1
Bone: periosteal estimation	0.2	0.5	0.8	-0.8	-0.9	-0.9	-0.9	-0.9	-0.8	0.6	0.6	0.7	-0.7	0.4	0.6	-0.3
Bone: periosteal perimeter	0.1	0.1	0.4	-0.4	-0.2	-0.2	-0.2	-0.2	-0.1	-0.0	-0.1	0.5	0.1	-0.3	0.6	-0.5
Bone: post-yield work	0.3	0.5	1.5	0.8	0.5	0.4	0.4	0.5	0.5	-0.6	-0.7	-0.7	0.4	-0.8	-1.1	1.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.5	-0.3	-0.1	0.0	-0.1	-0.0	-0.1	0.1	0.2	0.4	-0.1	-0.1	0.5	-0.7
Progressive ratio test 1 breakpoint	0.1	0.1	0.5	-0.3	-0.0	0.1	0.0	0.0	0.0	0.0	0.1	0.4	-0.0	-0.2	0.5	-0.7
Progressive ratio test 1 inactive lever presses	1.2	1.7	3.4	-1.6	-1.1	-1.1	-1.1	-1.1	-1.1	1.1	1.1	1.6	-0.9	1.1	1.9	-1.8
Progressive ratio test 2 active lever presses	0.7	0.8	1.4	0.5	0.9	1.0	1.0	1.0	1.0	-1.0	-1.1	-0.0	1.2	-1.0	0.3	-0.7
Progressive ratio test 2 breakpoint	0.7	0.8	1.5	0.5	1.0	1.1	1.0	1.0	1.0	-1.1	-1.1	-0.1	1.2	-1.1	0.3	-0.6
Progressive ratio test 2 inactive lever presses	0.2	0.3	1.4	-0.4	0.1	0.1	0.2	0.2	0.2	-0.2	-0.1	0.5	0.3	-0.2	1.1	-1.2
Incentive Sensitization - Responses	0.9	1.2	2.1	0.8	1.3	1.2	1.3	1.3	1.3	-1.3	-1.3	-0.4	1.4	-1.2	-0.1	-0.2
Incentive Sensitization - Breakpoint	0.9	1.1	2.0	0.8	1.2	1.1	1.2	1.2	1.2	-1.3	-1.3	-0.4	1.4	-1.1	-0.1	-0.1
Sum of active levers in priming session hrs 5-6	2.0	1.9	3.2	1.7	1.2	1.2	1.1	1.2	1.2	-1.3	-1.2	-1.6	1.1	-1.3	-1.8	1.8
Progressive ratio	0.1	0.2	0.9	-0.3	0.2	0.3	0.3	0.3	0.2	-0.3	-0.2	0.8	0.3	-0.4	0.8	-1.0
Food seeking constrained by brief footshock	0.0	0.0	0.1	-0.2	-0.1	-0.1	-0.1	-0.1	-0.1	0.1	0.1	0.2	-0.1	0.2	0.2	-0.3
Seeking ratio, punishment vs. effort	0.7	1.0	1.8	-0.7	-1.1	-1.2	-1.1	-1.1	-1.1	1.2	1.1	0.3	-1.2	1.4	-0.0	0.4
Retroperitoneal fat weight	0.1	0.5	1.4	1.1	0.8	0.5	0.8	0.7	0.6	-0.5	-0.5	-0.7	0.3	-0.2	-1.2	0.6
Reaction time number correct	0.0	0.1	0.2	0.4	0.3	0.3	0.3	0.4	0.2	-0.2	-0.1	-0.3	0.0	-0.1	-0.4	0.2
Reaction time mean minus median	0.0	0.1	0.3	-0.1	0.2	0.1	0.2	0.3	0.2	-0.3	-0.3	0.2	0.4	-0.4	0.5	-0.5
Reaction time mean minus median AUC	0.6	1.5	2.3	0.9	1.4	1.3	1.4	1.5	1.4	-1.4	-1.3	-0.9	1.4	-1.4	-0.2	-0.2
Reaction time num false alarms	0.4	0.5	1.2	0.1	0.8	0.9	0.9	0.9	0.8	-0.7	-0.7	0.3	0.6	-0.4	0.8	-1.1
Reaction time num false alarms AUC	0.3	0.5	1.1	0.0	0.7	0.8	0.8	0.8	0.7	-0.6	-0.6	0.3	0.6	-0.3	0.9	-1.1
Reaction time trials correct on left	0.0	0.1	0.2	0.4	0.3	0.3	0.3	0.4	0.2	-0.2	-0.1	-0.3	0.0	-0.1	-0.4	0.2
Reaction time trials on left	0.0	0.1	0.2	0.4	0.3	0.4	0.3	0.4	0.3	-0.2	-0.1	-0.3	0.1	-0.1	-0.3	0.1
Reaction time mean	0.0	0.0	0.1	-0.2	-0.2	-0.2	-0.2	-0.2	-0.1	-0.0	-0.0	0.3	0.0	-0.3	0.2	0.0
Reaction time mean AUC	0.1	0.1	0.4	-0.4	-0.3	-0.3	-0.3	-0.2	-0.2	0.1	0.1	0.6	-0.0	-0.2	0.6	-0.4
Median of all reaction times	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.5	-0.4	-0.4	0.2	0.2	0.5	-0.2	-0.0	0.2	0.1
Reaction time omissions	0.1	0.1	0.2	0.2	0.3	0.2	0.3	0.3	0.3	-0.3	-0.3	-0.5	0.3	-0.4	-0.1	0.2
Reaction time false alarm rate	0.3	0.4	0.8	-0.0	0.6	0.7	0.7	0.7	0.6	-0.6	-0.6	0.2	0.6	-0.4	0.8	-0.9
Reaction time premature initiation rate	0.6	0.9	1.2	0.9	1.0	1.0	1.0	1.1	1.0	-1.0	-1.0	-1.1	1.0	-0.8	-0.5	0.3
Reaction time premature initiations	0.6	1.0	1.6	1.1	1.2	1.2	1.2	1.3	1.2	-1.1	-1.0	-1.1	1.0	-0.8	-0.5	0.3
Std. dev. reaction times	0.1	0.2	0.5	-0.0	0.3	0.3	0.3	0.4	0.4	-0.5	-0.6	0.1	0.6	-0.7	0.5	-0.5
Reaction time trials completed	0.0	0.1	0.2	0.4	0.3	0.4	0.3	0.4	0.3	-0.2	-0.1	-0.3	0.1	-0.1	-0.3	0.1
Reaction time trials AUC	0.0	0.1	0.1	0.4	0.3	0.3	0.3	0.4	0.3	-0.2	-0.1	-0.3	0.1	-0.1	-0.3	0.1
Run reversals in cocaine runway, females	0.2	0.2	1.2	-0.1	0.3	0.4	0.4	0.3	0.4	-0.2	-0.1	0.5	0.3	0.0	0.7	-1.1
Run reversals in cocaine runway, males	0.8	0.8	1.3	0.5	1.0	1.0	1.0	1.0	1.0	-1.0	-1.1	-0.3	1.1	-1.0	-0.0	-0.2
Latency to leave start box in cocaine runway	0.2	0.2	0.3	-0.4	-0.5	-0.5	-0.5	-0.5	-0.5	0.4	0.4	0.4	-0.4	0.4	0.2	-0.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.0	-0.4	-0.4	-0.5	-0.4	-0.4	0.4	0.4	-0.1	-0.4	0.3	-0.3	0.3
Latency to leave start box in cocaine runway, M	0.0	0.0	0.2	-0.3	-0.1	-0.1	-0.1	-0.1	-0.1	0.1	0.1	0.5	-0.1	0.1	0.3	-0.1
Std. dev. time between licks in bursts	0.3	0.4	0.7	0.7	0.6	0.8	0.6	0.6	0.7	-0.6	-0.6	-0.4	0.6	-0.7	-0.3	-0.0
Total sessions with >9 infusions	0.2	0.2	0.8	0.0	0.4	0.4	0.4	0.4	0.4	-0.4	-0.4	0.2	0.5	-0.4	0.5	-0.9
Short access day 1 total inactive lever presses	0.1	0.1	0.2	0.1	0.2	0.3	0.3	0.2	0.3	-0.3	-0.5	-0.1	0.5	-0.3	-0.2	0.0
Short access day 10 total inactive lever presses	0.4	0.9	1.6	-1.2	-0.9	-0.9	-0.9	-0.9	-0.9	0.8	0.7	1.0	-0.6	0.9	1.2	-1.0
Short access day 1 total infusions	0.3	0.5	2.5	-0.7	-0.2	-0.2	-0.2	-0.2	-0.2	0.1	0.1	1.0	0.0	0.1	1.3	-1.6
Short access day 10 total infusions	0.2	0.2	1.1	-0.2	0.2	0.1	0.2	0.3	0.2	-0.2	-0.1	0.7	0.2	-0.2	0.7	-1.1
Short access total infusions	0.3	0.4	2.1	-0.6	-0.2	-0.2	-0.2	-0.2	-0.2	0.2	0.2	0.9	-0.1	0.1	1.1	-1.5
Short access day 1 locomotion	1.2	1.5	3.2	-1.5	-1.1	-0.8	-1.0	-1.0	-1.0	1.0	1.0	1.5	-0.9	0.9	1.7	-1.8
Short access day 10 total locomotion	0.5	1.0	2.2	-1.2	-0.8	-0.8	-0.8	-0.7	-0.8	0.8	0.9	1.1	-0.7	0.9	1.5	-1.3
Short access total locomotion	1.6	1.9	4.3	-1.7	-1.1	-1.0	-1.1	-1.0	-1.1	1.1	1.2	1.7	-1.0	1.1	2.1	-2.0
One hour access (0.3 mA shock)	1.1	1.3	2.0	0.9	1.2	1.4	1.2	1.3	1.3	-1.3	-1.2	-0.6	1.3	-1.4	-0.3	-0.1
Compulsive drug intake	0.4	0.4	1.7	0.8	0.4	0.4	0.3	0.3	0.3	-0.4	-0.4	-0.8	0.3	-0.3	-1.2	1.3
One hour access (shock baseline)	0.1	0.1	0.5	-0.1	0.2	0.3	0.3	0.3	0.3	-0.3	-0.2	0.2	0.3	-0.4	0.5	-0.7
Social response proportion	1.3	1.4	5.8	1.4	0.7	0.7	0.6	0.6	0.6	-0.8	-0.8	-1.5	0.6	-0.9	-2.0	2.4
Social responses	1.3	1.7	3.8	1.6	1.2	1.1	1.0	1.2	1.1	-1.2	-1.1	-1.5	0.9	-1.2	-1.7	1.9
Social time	2.3	3.2	4.4	2.1	1.7	1.6	1.5	1.7	1.6	-1.8	-1.8	-1.7	1.5	-1.9	-2.0	2.0
Soleus weight	2.7	8.0	15.4	3.4	2.6	2.5	2.5	2.5	2.5	-2.3	-2.2	-3.6	2.0	-1.9	-3.9	3.8
Bone: stiffness	0.5	0.7	3.4	0.9	0.4	0.4	0.4	0.4	0.4	-0.5	-0.5	-1.2	0.3	-0.5	-1.5	1.8
Tibialis anterior weight	9.6	32.7	39.1	6.0	6.3	6.1	6.3	6.2	6.2	-6.0	-5.9	-5.6	5.8	-5.7	-4.2	2.9
Time to tail flick, vehicle, before self-admin	7.0	7.3	9.0	3.0	2.8	2.8	2.8	2.8	2.8	-2.8	-2.8	-2.6	2.6	-2.7	-2.4	1.9
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.6	0.8	0.7	0.7	0.7	0.7	0.7	-0.7	-0.7	-0.3	0.6	-0.8	-0.6	0.4
Time to tail flick, test, before self-admin	0.7	0.7	1.2	1.0	0.7	0.7	0.7	0.7	0.7	-0.7	-0.7	-1.1	0.7	-0.7	-1.1	1.1
Time to tail flick, test, after self-admin	0.2	0.2	0.3	-0.3	-0.5	-0.6	-0.6	-0.5	-0.5	0.4	0.4	0.4	-0.5	0.3	-0.0	0.1
Delta time to tail flick, vehicle, before/after SA	1.1	1.0	1.7	-1.2	-0.9	-0.9	-0.9	-0.9	-0.9	0.9	0.9	1.3	-0.8	0.8	1.3	-1.2
Delta time to tail flick, test, before/after SA	0.3	0.3	1.0	-0.6	-0.3	-0.4	-0.3	-0.3	-0.3	0.2	0.2	0.8	-0.2	0.2	0.9	-1.0
Tibia length	0.5	1.3	2.1	-0.4	-1.3	-1.3	-1.3	-1.4	-1.3	1.1	1.1	0.3	-1.3	0.8	-0.8	1.4
Ambulatory time before self-admin	4.1	6.1	7.3	-2.6	-2.6	-2.5	-2.5	-2.6	-2.6	2.7	2.7	2.3	-2.7	2.7	1.9	-1.5
Ambulatory time after self-admin	0.5	0.6	0.9	-0.5	-0.9	-1.0	-1.0	-0.9	-0.9	0.9	0.8	0.3	-1.0	0.8	-0.1	0.4
Bone: tissue strength	2.7	2.8	3.4	-1.8	-1.8	-1.7	-1.8	-1.7	-1.8	1.8	1.8	1.6	-1.8	1.8	1.2	-0.5
Total heroin consumption	4.1	4.8	6.5	2.5	2.1	2.1	2.1	2.1	2.1	-2.1	-2.0	-2.4	1.9	-2.2	-2.4	2.2
Bone: trabecular number	5.1	8.4	10.5	3.2	3.1	3.2	3.1	3.0	3.0	-2.9	-2.9	-3.1	2.7	-2.7	-2.6	1.9
Bone: trabecular spacing	0.6	0.8	1.3	-1.1	-0.9	-1.0	-0.9	-0.8	-0.9	0.9	0.8	1.0	-0.8	0.7	1.1	-0.8
Bone: trabecular thickness	0.5	0.6	0.8	0.8	0.8	0.9	0.8	0.7	0.8	-0.8	-0.8	-0.8	0.6	-0.6	-0.8	0.6
Bone: trabecular tissue density	2.3	3.4	3.9	-2.0	-1.9	-1.8	-1.9	-1.9	-1.9	1.9	1.9	2.0	-1.8	1.9	1.7	-1.3
Water consumed over 24 hours	0.7	1.0	1.6	-0.7	-1.1	-1.2	-1.2	-1.1	-1.1	1.1	1.2	0.5	-1.3	1.1	-0.1	0.4
Number of responses in last shaping day	1.2	1.4	3.8	-1.4	-0.9	-0.8	-0.9	-0.8	-0.9	0.8	0.8	1.5	-0.7	0.7	1.8	-2.0