Doc2b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Doc2b 0.28 0.13 0.0e+00 0.17 0.15 0.16 0.17 2.1e-18 1.4e-16 1.9e-17 2.2e-18
2 NAcc gene expression Doc2b 0.49 0.17 0.0e+00 0.39 0.39 0.39 0.39 1.7e-48 1.3e-47 9.4e-48 1.9e-48
3 Brain mRNA stability Doc2b 0.65 0.18 0.0e+00 0.4 0.41 0.43 0.42 8.3e-40 4.9e-41 2.3e-43 8.4e-43
4 Brain intron excision ratio chr10_60633027_60636786 0.17 0.11 3.0e-08 0.08 0.09 0.08 0.06 5.8e-08 2.5e-08 5.4e-08 6.6e-06
5 NAcc mRNA stability Doc2b 0.04 0.03 1.8e-03 0.02 0.03 0.02 0.02 2.8e-03 4.8e-04 1.1e-03 2.1e-03
6 Brain gene expression Doc2b 0.66 0.11 0.0e+00 0.53 0.54 0.56 0.48 1.3e-57 4.7e-59 3.4e-62 8.1e-51
7 IL gene expression Doc2b 0.24 0.13 2.2e-04 0.03 0.07 0.05 0 7.4e-02 8.4e-03 2.4e-02 2.4e-01
8 BLA mRNA stability Doc2b 0.23 0.15 4.9e-06 0.11 0.09 0.06 0.1 1.6e-06 2.4e-05 2.5e-04 7.9e-06
9 Eye intron excision ratio chr10_60642685_60643255 0.25 0.16 2.6e-03 0.15 0.19 0.17 0.15 2.4e-03 6.5e-04 1.6e-03 2.8e-03
10 Adipose gene expression Doc2b 0.12 0.07 1.2e-08 0.05 0.07 0.07 0.06 4.2e-06 3.1e-08 5.8e-08 1.3e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density4.16.98.8-2.8-2.82.9-3.0-2.9-2.72.82.6-2.40.7
Area under the delay curve2.22.33.61.51.5-1.71.71.71.7-1.5-1.91.1-0.2
BMI with tail1.03.14.4-2.1-2.12.0-1.8-2.0-1.81.71.8-1.30.2
BMI without tail0.20.50.8-0.4-0.40.6-0.5-0.6-0.50.80.8-0.90.9
Body weight0.94.09.9-1.6-1.61.6-1.7-1.6-0.82.80.7-3.12.7
Weight adjusted by age0.80.91.5-1.1-1.11.2-1.0-1.0-1.00.91.0-0.60.1
Bone surface3.15.58.0-2.8-2.82.7-2.5-2.6-2.42.41.9-1.80.2
Bone volume3.56.08.5-2.9-2.92.8-2.7-2.7-2.52.52.1-1.90.2
Breakpoint value in progressive ratio session0.70.82.2-0.5-0.50.6-0.7-0.6-0.21.30.6-1.51.5
Number of licking bursts0.50.61.50.50.5-0.90.80.91.0-0.7-1.20.5-0.3
Context. condit. distance diff. score1.41.72.6-1.2-1.21.2-1.6-1.5-1.31.51.3-1.30.6
Locomotion velocity, session 12.93.14.9-1.6-1.61.7-1.9-1.8-1.42.21.6-2.21.5
Locomotion distance, session 10.50.71.3-1.1-1.11.0-0.8-0.9-0.70.80.3-0.6-0.1
Locomotion velocity, session 20.60.81.1-1.0-1.00.9-1.0-1.0-0.81.00.6-0.80.3
Locomotion distance, session 21.42.03.1-1.8-1.81.7-1.5-1.6-1.41.50.9-1.10.1
Locomotion velocity, session 35.26.18.12.72.7-2.72.92.72.7-2.4-2.81.8-0.1
Locomotion distance, session 30.10.10.2-0.1-0.10.10.2-0.1-0.1-0.3-0.10.5-0.5
Stereotopy head waving bouts, day 30.20.20.70.40.4-0.50.30.40.60.1-0.4-0.50.8
Stereotopy head waving duration, day 30.40.51.10.30.3-0.80.70.80.9-0.7-1.10.5-0.4
Locomotion velocity, session 71.21.31.9-1.3-1.31.3-1.1-1.3-1.40.91.2-0.5-0.2
Locomotion distance, session 72.02.53.7-1.7-1.71.8-1.7-1.8-1.91.41.8-0.9-0.1
Stereotopy head waving bouts, day 70.60.71.3-1.1-1.10.7-0.8-0.8-0.31.00.1-1.00.5
Stereotopy head waving duration, day 70.81.01.9-1.4-1.41.0-0.9-1.0-0.41.30.2-1.20.6
Locomotion velocity, session 80.40.50.9-0.9-0.90.7-0.8-0.8-0.80.60.6-0.3-0.2
Locomotion distance, session 81.82.74.2-1.8-1.81.6-1.8-1.8-1.32.10.9-1.91.0
Degree of sensitization distance1.41.41.9-1.0-1.01.1-1.4-1.2-1.11.41.3-1.30.7
Degree of sensitization stereotypy1.01.11.9-1.2-1.20.9-1.0-1.0-0.51.40.4-1.40.9
Conditioned locomotion0.30.30.70.50.5-0.30.40.40.0-0.80.30.8-0.8
Cocaine response after cond. corrected0.20.20.60.20.20.2-0.4-0.2-0.20.50.6-0.70.8
Cocaine response after cond. not corrected0.40.51.1-0.1-0.10.5-0.7-0.5-0.40.90.8-1.01.0
Cocaine response before conditioning0.80.91.6-1.3-1.31.1-0.9-1.0-0.81.10.7-0.90.5
Saline control response0.40.51.2-1.1-1.10.9-0.7-0.8-0.60.70.4-0.4-0.3
Bone: connectivity density5.89.111.8-3.3-3.33.4-3.3-3.4-3.13.13.0-2.50.5
Bone: cortical apparent density0.20.31.40.10.1-0.30.10.2-0.1-0.7-0.01.0-1.2
Bone: cortical area1.72.53.31.71.7-1.71.81.71.4-1.8-1.41.6-0.5
Bone: cortical porosity0.10.10.2-0.3-0.30.3-0.3-0.3-0.30.40.4-0.40.3
Bone: cortical porosity0.00.00.10.00.00.00.10.10.10.00.1-0.10.2
Bone: cortical thickness5.38.811.33.43.4-3.33.33.33.1-2.9-3.02.3-0.1
Bone: cortical thickness1.21.32.01.41.4-1.31.31.31.3-0.8-1.00.30.7
Bone: cortical tissue density0.20.21.20.00.0-0.1-0.00.0-0.2-0.50.10.8-1.1
Condit. Reinf. active minus inactive responses0.20.20.40.50.5-0.60.60.50.6-0.2-0.4-0.00.5
Condit. Reinf. active-inactive response ratio2.52.74.11.91.9-1.91.81.82.0-1.0-1.70.31.3
Condit. Reinf. active responses0.40.51.2-0.7-0.70.8-0.7-0.7-0.80.51.1-0.40.0
Condit. Reinf. inactive responses4.45.38.8-2.6-2.62.7-2.4-2.4-2.81.33.0-0.4-1.5
Incentive salience index mean0.10.20.80.40.4-0.40.30.30.50.1-0.3-0.30.9
Condit. Reinf. lever presses0.40.62.3-0.3-0.30.4-0.5-0.6-0.31.00.5-1.21.5
Condit. Reinf. active minus inactive responses0.30.40.7-0.8-0.80.7-0.7-0.7-0.60.60.3-0.50.1
Condit. Reinf. active-inactive response ratio0.10.10.20.40.4-0.20.20.30.3-0.0-0.2-0.20.5
Condit. Reinf. active responses0.71.02.6-1.6-1.61.0-0.9-1.1-0.90.80.4-0.3-0.5
Condit. Reinf. inactive responses2.02.45.7-2.4-2.41.6-1.3-1.6-1.50.80.8-0.0-1.4
Condit. Reinf. lever presses0.40.51.8-0.1-0.1-0.30.60.40.3-0.9-0.81.2-1.3
Condit. Reinf. lever reinforcers received0.60.92.5-1.6-1.61.0-0.8-1.0-0.80.60.3-0.2-0.7
Conditioned reinforcement - actives2.72.74.0-1.8-1.82.0-1.8-1.9-2.01.31.7-0.7-0.5
Conditioned reinforcement - inactives0.80.91.5-1.0-1.00.9-1.0-1.1-1.20.61.2-0.2-0.5
Conditioned locomotion0.20.20.50.10.1-0.20.60.40.3-0.6-0.60.7-0.6
Patch foraging indifference point 0 sec0.20.30.5-0.6-0.60.7-0.4-0.5-0.60.40.7-0.2-0.0
Patch foraging indifference point AUC0.30.31.40.00.0-0.30.10.10.0-0.7-0.40.9-1.2
Delay disc. indifference point, 0s delay0.00.00.1-0.3-0.3-0.10.10.10.30.1-0.2-0.20.1
Delay disc. indifference point, 16s delay1.11.12.20.90.9-1.21.11.21.2-1.0-1.50.8-0.4
Delay disc. indifference point, 2s delay1.61.72.51.31.3-1.51.51.51.5-1.3-1.61.0-0.3
Delay disc. indifference point, 24s delay0.40.30.60.60.6-0.70.60.60.6-0.6-0.70.5-0.1
Delay disc. indifference point, 4s delay1.31.42.11.21.2-1.41.31.31.4-1.0-1.40.60.2
Delay disc. indifference point, 8s delay1.01.11.81.11.1-1.11.21.21.2-0.9-1.30.70.0
Indifference point function ln k0.70.91.2-1.0-1.01.1-1.0-1.1-1.01.01.0-0.80.4
Indifference point function log k0.70.91.2-1.0-1.01.1-1.0-1.1-1.01.01.0-0.80.4
Patch foraging total patch changes 0 sec0.20.30.6-0.7-0.70.8-0.4-0.6-0.70.30.7-0.1-0.2
Patch foraging total patch changes 12 sec0.60.71.10.90.9-1.01.00.90.9-0.9-0.90.7-0.1
Patch foraging total patch changes 18 sec1.01.32.51.01.0-1.41.31.31.5-1.0-1.60.60.1
Patch foraging total patch changes 24 sec0.91.11.61.01.0-1.11.21.11.0-1.2-1.31.1-0.5
Patch foraging total patch changes 6 sec0.20.31.1-0.1-0.1-0.00.40.2-0.1-0.60.10.9-1.0
Patch foraging time to switch 0 sec1.32.03.41.61.6-1.61.51.71.8-0.7-1.40.01.2
Patch foraging water rate 0 sec0.40.71.4-1.0-1.00.9-0.7-0.8-1.00.20.70.4-1.2
Patch foraging water rate 12 sec0.00.00.0-0.1-0.10.1-0.2-0.1-0.10.1-0.2-0.1-0.0
Patch foraging water rate 18 sec2.63.54.9-2.2-2.22.2-2.2-2.1-1.91.91.4-1.50.0
Patch foraging water rate 24 sec0.20.30.6-0.8-0.80.6-0.4-0.5-0.60.20.30.1-0.6
Patch foraging water rate 6 sec0.20.20.80.10.1-0.20.40.20.1-0.7-0.40.9-0.9
Seeking ratio, delayed vs. immediate footshock1.51.83.00.90.9-1.21.51.41.1-1.7-1.11.7-1.3
Distance traveled before self-admin2.12.22.91.51.5-1.61.71.61.5-1.6-1.71.4-0.6
Distance traveled after self-admin0.10.10.20.30.3-0.40.40.30.4-0.1-0.4-0.00.4
Extensor digitorum longus weight5.421.430.6-5.5-5.55.3-5.1-5.3-5.14.24.3-2.9-0.5
Bone: elastic displacement0.40.41.00.40.4-0.50.50.50.3-0.9-0.51.0-1.0
Bone: elastic work4.55.88.02.62.6-2.72.82.62.5-2.4-2.52.0-0.2
Bone: endosteal estimation0.10.10.3-0.5-0.50.4-0.3-0.4-0.40.20.10.0-0.4
Bone: endosteal perimeter0.81.72.6-1.6-1.61.5-1.3-1.4-1.60.71.4-0.1-1.1
Epididymis fat weight2.96.710.5-2.6-2.62.6-2.8-2.6-2.13.22.1-3.11.8
Delta time in closed arm before/after self-admin0.30.30.80.10.1-0.40.30.40.3-0.7-0.40.8-0.9
Delta time in open arm before/after self-admin0.60.61.2-0.7-0.70.7-0.6-0.7-0.41.10.5-1.11.0
Diff in mean of infusions in LGA sessions0.40.41.9-0.1-0.10.2-0.4-0.4-0.10.80.4-1.11.4
Delay discount exponential model param2.12.23.4-1.5-1.51.7-1.7-1.7-1.71.41.9-1.0-0.0
Extinction: sum of active levers before priming2.02.02.6-1.6-1.61.4-1.6-1.6-1.41.51.3-1.20.4
Active lever presses in extinction session 61.21.21.5-1.2-1.21.1-1.1-1.2-1.01.21.1-1.00.4
Bone: final force1.01.72.61.41.4-1.31.61.31.5-0.7-1.50.21.3
Bone: final moment0.91.42.21.31.3-1.21.51.21.4-0.7-1.40.31.0
Food consumed during 24 hour testing period0.30.40.6-0.6-0.60.6-0.6-0.7-0.70.60.8-0.50.3
Glucose3.55.36.42.42.4-2.52.52.52.3-2.5-2.52.2-0.9
Heart weight0.10.10.6-0.1-0.10.10.10.00.20.4-0.3-0.60.8
Delay discount hyperbolic model param2.02.23.3-1.4-1.41.7-1.7-1.6-1.71.41.8-1.10.1
Intermittent access intake day 1-15 change0.70.73.1-0.5-0.50.6-0.3-0.4-0.9-0.50.71.1-1.8
Intermittent access intake escalation0.70.73.00.20.2-0.20.50.4-0.1-1.1-0.11.5-1.7
Intermittent access intake escalation 21.11.13.00.70.7-0.70.80.80.4-1.4-0.51.7-1.7
Intermitt. access day 1 inactive lever presses2.52.73.91.71.7-1.71.91.81.5-2.0-1.41.8-0.8
Intermitt. access day 15 inactive lever presses0.50.61.20.60.6-0.70.60.70.5-1.0-0.51.1-1.1
Intermitt. access escalation Index2.01.88.50.30.30.2-0.5-0.20.41.6-0.1-2.42.9
Intermittent access day 1 total infusions0.50.61.0-1.0-1.00.8-0.8-0.8-0.70.70.7-0.5-0.0
Intermittent access day 15 total infusions0.91.12.0-1.2-1.21.1-0.8-1.0-1.30.21.10.5-1.4
Intermittent access terminal intake (last 3 days)1.71.82.5-1.6-1.61.5-1.5-1.5-1.61.01.5-0.6-0.5
Intermittent access total infusions0.50.60.9-0.9-0.90.9-0.7-0.8-0.90.30.80.2-0.9
Intermittent access day 1 locomotion0.40.50.90.60.6-0.70.90.70.8-0.6-1.00.40.2
Intermittent access day 15 total locomotion0.30.30.90.10.1-0.40.50.40.2-0.8-0.51.0-1.0
Intermittent access total locomotion0.10.10.20.10.1-0.10.30.20.1-0.4-0.50.5-0.3
Intermittent access standard deviation1.31.47.4-0.4-0.40.4-0.1-0.3-0.9-1.10.61.9-2.7
Left kidney weight3.710.416.13.53.5-3.63.63.64.0-2.2-4.01.01.6
Right kidney weight3.08.513.33.23.2-3.23.23.33.6-1.8-3.60.61.8
Cocaine induced anxiety0.30.31.7-0.4-0.40.1-0.3-0.3-0.5-0.30.30.7-1.3
Post-drug Anxiety0.20.20.4-0.6-0.60.4-0.6-0.5-0.50.20.40.0-0.6
Baseline Anxiety0.10.10.40.20.2-0.00.00.10.20.2-0.0-0.40.6
Tail length1.23.517.01.11.1-0.90.40.71.71.5-1.4-2.74.1
Length with tail0.62.210.70.30.3-0.2-0.20.10.91.7-1.0-2.63.3
Length without tail0.71.63.9-1.2-1.21.1-1.2-1.0-0.61.80.3-2.01.5
Times rat made contact with spout1.51.72.41.51.5-1.41.51.41.6-0.9-1.40.40.9
Lifetime Intake0.60.71.0-0.9-0.90.9-0.7-0.8-1.00.20.90.3-1.0
Liver weight, left0.60.94.70.80.8-0.50.20.40.70.7-0.3-1.32.2
Liver weight, right0.40.63.10.10.1-0.0-0.3-0.20.10.90.2-1.41.8
Locomotor activity0.00.00.1-0.3-0.30.0-0.1-0.10.10.2-0.3-0.30.1
Locomotor testing distance0.00.00.0-0.2-0.20.1-0.0-0.00.10.1-0.2-0.2-0.0
Locomotor testing rearing0.30.40.9-1.0-1.00.7-0.6-0.6-0.60.40.6-0.1-0.7
Locomotion in novel chamber1.82.28.00.50.5-0.71.10.80.1-2.1-0.52.7-2.8
Locomotion in novel chamber post-restriction0.20.20.3-0.5-0.50.4-0.3-0.5-0.60.10.50.2-0.6
Fecal boli incidents, locomotor time 10.10.10.2-0.1-0.10.1-0.2-0.2-0.10.4-0.3-0.40.4
Change in fecal boli incidents, locomotor task0.40.40.80.90.9-0.80.70.70.7-0.5-0.30.20.5
Time >=10cm from walls, locomotor time 10.20.20.6-0.5-0.50.6-0.3-0.6-0.80.10.70.2-0.2
Bouts of movement, locomotor time 10.20.20.8-0.4-0.40.4-0.5-0.5-0.60.30.9-0.2-0.0
Total resting periods, locomotor time 10.30.41.2-0.5-0.50.5-0.6-0.6-0.80.31.1-0.1-0.2
Rest time, locomotor task time 10.20.20.8-0.3-0.30.2-0.4-0.3-0.6-0.20.70.5-0.9
Distance moved, locomotor task time 10.00.10.1-0.2-0.20.3-0.2-0.3-0.30.10.30.0-0.1
Vertical activity count, locomotor time 10.60.60.9-1.0-1.01.0-0.7-0.9-0.80.70.8-0.4-0.1
Time >=10cm from walls, locomotor time 20.90.91.81.01.0-1.01.41.00.9-1.1-0.71.00.1
Bouts of movement, locomotor time 20.20.20.30.50.5-0.50.40.50.5-0.4-0.40.20.0
Total resting periods, locomotor time 20.00.00.00.20.2-0.2-0.00.10.10.0-0.0-0.10.1
Rest time, locomotor task time 20.40.40.8-0.6-0.60.7-0.9-0.7-0.80.50.8-0.3-0.3
Distance moved, locomotor task time 20.30.30.9-0.1-0.1-0.40.50.40.3-0.7-0.20.9-1.0
Vertical activity count, locomotor time 20.50.50.80.60.6-0.80.90.90.8-0.8-0.60.6-0.2
Light reinforcement 10.00.10.2-0.4-0.4-0.00.10.10.20.0-0.1-0.0-0.2
Light reinforcement 22.83.75.51.91.9-2.22.32.32.3-1.7-2.21.10.2
Bone: marrow area0.10.10.3-0.5-0.50.4-0.3-0.4-0.40.20.10.0-0.4
Bone: maximum diameter0.20.41.3-0.4-0.40.5-0.2-0.4-0.8-0.40.80.9-1.2
Bone: maximum force1.11.92.81.51.5-1.41.71.51.6-0.9-1.70.50.9
Bone: maximum moment0.91.52.61.31.3-1.31.51.31.4-1.0-1.60.60.6
Mean time between licks in bursts0.30.51.40.30.3-0.40.10.30.80.5-1.0-0.91.2
Mean num. licks in bursts0.20.21.00.60.6-0.10.30.10.00.10.4-0.31.0
Cd content in liver1.11.22.2-1.2-1.21.1-1.5-1.2-1.11.10.8-0.9-0.2
Co content in liver0.20.30.60.40.4-0.60.60.60.6-0.5-0.80.4-0.1
Cu content in liver0.91.11.71.31.3-1.21.21.21.1-0.8-0.90.50.5
Fe content in liver0.20.31.40.30.3-0.20.00.20.40.5-0.1-0.91.2
K content in liver1.31.32.81.01.0-1.11.01.01.5-0.1-1.5-0.61.7
Mg content in liver0.10.10.10.00.0-0.20.30.10.1-0.3-0.40.4-0.2
Mn content in liver0.20.30.5-0.7-0.70.5-0.6-0.7-0.60.50.3-0.3-0.1
Na content in liver3.63.85.22.12.1-2.22.22.22.3-1.7-2.21.10.3
Rb content in liver1.51.82.8-1.6-1.61.5-1.4-1.5-1.70.91.6-0.4-0.6
Se content in liver1.01.21.81.31.3-1.31.21.31.2-1.0-1.10.70.1
Sr content in liver1.00.91.2-1.0-1.01.0-1.0-1.1-1.10.91.1-0.70.1
Zn content in liver0.70.81.4-0.9-0.91.0-0.9-1.0-1.20.51.1-0.1-0.6
Bone: minimum diameter0.91.72.51.51.5-1.41.31.51.5-1.0-1.60.50.4
Time in familiar zone, hab. session 11.61.52.8-1.4-1.41.4-1.2-1.4-1.70.51.30.2-1.3
Time in novel zone, hab. session 11.51.52.71.31.3-1.41.21.31.7-0.5-1.4-0.11.1
Total zone transitions, hab. session 11.42.04.3-2.1-2.11.7-1.4-1.5-1.31.00.6-0.3-1.1
Total locomotion distance, hab. session 10.50.71.4-1.2-1.20.9-0.9-0.8-0.50.80.0-0.6-0.3
Locomotion velocity, hab. session 10.60.81.6-1.3-1.31.0-1.0-1.0-0.80.80.3-0.5-0.5
Time in familiar zone, hab. session 21.92.03.0-1.7-1.71.6-1.6-1.6-1.51.21.1-0.8-0.5
Time in novel zone, hab. session 24.84.86.82.62.6-2.52.62.52.4-2.0-1.91.30.6
Total zone transitions, hab. session 20.70.91.9-1.4-1.41.1-0.9-1.0-0.61.10.2-0.90.1
Total locomotion distance, hab. session 20.10.10.2-0.3-0.30.2-0.2-0.20.10.4-0.3-0.50.3
Locomotion velocity, hab. session 20.00.10.2-0.2-0.20.1-0.2-0.10.10.3-0.3-0.40.3
Novel to familiar place preference ratio0.20.20.60.10.10.20.2-0.0-0.4-0.50.60.7-0.8
Novelty place preference0.10.10.40.10.10.20.1-0.0-0.3-0.30.60.4-0.3
Time in novel zone, NPP test0.10.10.6-0.1-0.10.4-0.2-0.3-0.40.00.70.1-0.2
Total zone transitions, NPP test0.71.02.5-1.6-1.61.1-1.0-1.0-0.70.9-0.3-0.5-0.6
Total locomotion distance, NPP test0.20.30.8-0.8-0.80.3-0.3-0.4-0.10.1-0.70.2-0.9
Locomotion velocity, NPP test0.20.31.6-0.4-0.40.0-0.0-0.10.1-0.4-0.80.7-1.3
Intraocular pressure0.50.73.7-0.8-0.80.5-0.5-0.5-0.8-0.40.31.0-1.9
Delta distance traveled before/after self-admin1.51.72.6-1.1-1.11.1-1.3-1.3-1.01.61.3-1.61.3
Delta ambulatory time before/after self-admin1.21.42.1-1.0-1.01.0-1.2-1.2-1.01.41.2-1.41.1
Parametrial fat weight6.512.621.9-3.3-3.33.4-3.6-3.4-2.54.62.8-4.73.3
Pavlov. Cond. lever latency0.30.40.9-0.6-0.60.7-0.6-0.5-0.70.10.50.2-0.9
Pavlov. Cond. magazine entry latency0.40.51.4-0.2-0.20.5-0.5-0.5-0.50.91.0-1.01.2
Pavlov. Cond. change in total contacts0.60.61.00.90.9-1.00.80.90.8-0.7-0.70.60.1
Pavlov. Cond. index score0.20.31.80.10.10.0-0.1-0.10.00.60.3-0.91.3
Pavlov. Cond. latency score0.30.42.60.30.3-0.20.10.10.30.60.1-0.91.6
Pavlov. Cond. lever contacts0.20.30.80.50.5-0.50.40.40.50.0-0.4-0.30.9
Pavlov. Cond. magazine entry number0.20.20.50.10.1-0.30.40.30.3-0.5-0.70.6-0.6
Pavlov. Cond. intertrial magazine entries0.40.51.6-1.0-1.00.6-0.4-0.4-0.5-0.0-0.10.4-1.2
Pavlov. Cond. lever-magazine prob. diff.0.20.31.2-0.1-0.10.1-0.3-0.3-0.20.60.5-0.81.1
Pavlov. Cond. response bias0.20.20.7-0.1-0.10.2-0.3-0.3-0.20.50.5-0.70.8
Pavlov. Cond. lever latency1.41.92.6-1.1-1.11.4-1.5-1.5-1.41.61.6-1.50.9
Pavlov. Cond. magazine entry latency1.92.24.31.41.4-1.51.71.71.9-1.1-2.10.60.4
Pavlov. Cond. change in total contacts1.21.72.81.11.1-1.41.61.41.4-1.3-1.71.0-0.2
Pavlov. Cond. index score2.12.74.51.41.4-1.71.91.81.8-1.7-2.11.5-0.8
Pavlov. Cond. latency score2.53.15.21.41.4-1.82.01.91.9-1.9-2.31.7-0.9
Pavlov. Cond. lever contacts1.11.52.51.11.1-1.31.41.41.4-1.2-1.61.0-0.3
Pavlov. Cond. magazine entry number1.92.33.7-1.5-1.51.6-1.8-1.7-1.81.31.9-0.9-0.2
Pavlov. Cond. intertrial magazine entries2.63.34.4-2.0-2.02.0-2.1-2.0-2.01.72.1-1.3-0.1
Pavlov. Cond. lever-magazine prob. diff.1.92.43.91.31.3-1.61.81.71.6-1.6-2.01.5-0.7
Pavlov. Cond. response bias1.62.23.31.41.4-1.61.71.71.7-1.4-1.81.0-0.2
Time in closed arm before self-admin1.82.14.1-1.1-1.11.3-1.4-1.3-1.01.91.2-2.01.6
Time in closed arm after self-admin0.00.00.10.30.3-0.30.10.30.2-0.2-0.20.1-0.0
Time in open arm before self-admin5.35.78.02.42.4-2.62.62.52.2-2.8-2.32.6-1.3
Time in open arm after self-admin1.01.11.71.01.0-1.21.31.00.9-1.3-1.11.3-0.5
Bone: periosteal estimation0.30.60.90.80.8-0.80.90.90.7-0.9-0.90.8-0.3
Bone: periosteal perimeter0.10.20.70.10.10.00.20.1-0.2-0.60.20.8-0.9
Bone: post-yield work0.20.30.7-0.4-0.40.4-0.4-0.4-0.20.7-0.1-0.80.8
Progressive ratio test 1 active lever presses0.30.30.6-0.6-0.60.7-0.6-0.6-0.60.50.8-0.30.0
Progressive ratio test 1 breakpoint0.80.81.3-1.0-1.01.1-0.9-1.0-0.90.91.1-0.70.2
Progressive ratio test 1 inactive lever presses0.40.51.20.60.6-0.60.70.50.3-0.9-0.51.1-0.7
Progressive ratio test 2 active lever presses0.40.50.9-0.8-0.80.7-0.6-0.7-0.90.20.90.2-0.7
Progressive ratio test 2 breakpoint0.40.50.8-0.7-0.70.8-0.6-0.7-0.90.20.90.3-0.8
Progressive ratio test 2 inactive lever presses0.30.31.4-0.3-0.30.3-0.1-0.3-0.6-0.40.40.9-1.2
Incentive Sensitization - Responses0.20.20.3-0.5-0.50.3-0.3-0.4-0.50.00.50.2-0.6
Incentive Sensitization - Breakpoint0.10.10.3-0.3-0.30.2-0.2-0.3-0.4-0.00.40.2-0.5
Sum of active levers in priming session hrs 5-61.61.62.8-1.0-1.01.0-1.2-1.2-0.91.61.2-1.71.5
Progressive ratio0.50.51.0-0.9-0.90.8-0.4-0.6-0.80.00.80.5-1.0
Food seeking constrained by brief footshock0.10.10.20.30.3-0.30.30.40.3-0.4-0.50.3-0.2
Seeking ratio, punishment vs. effort0.91.11.81.31.3-1.20.81.11.3-0.5-1.3-0.00.7
Retroperitoneal fat weight0.00.10.80.10.1-0.40.20.30.50.0-0.9-0.20.1
Reaction time number correct0.00.10.1-0.3-0.30.1-0.1-0.1-0.00.30.3-0.30.4
Reaction time mean minus median0.10.21.0-0.3-0.30.0-0.2-0.1-0.4-0.30.30.6-1.0
Reaction time mean minus median AUC1.11.52.3-1.5-1.51.2-1.4-1.3-1.40.71.3-0.1-1.1
Reaction time num false alarms0.50.73.0-0.9-0.90.8-0.4-0.5-0.8-0.30.50.8-1.7
Reaction time num false alarms AUC0.50.72.8-0.8-0.80.7-0.3-0.5-0.7-0.40.40.9-1.7
Reaction time trials correct on left0.00.10.1-0.3-0.30.1-0.1-0.1-0.00.30.3-0.30.4
Reaction time trials on left0.00.10.2-0.3-0.30.1-0.1-0.2-0.00.30.4-0.30.3
Reaction time mean0.00.10.10.30.3-0.20.00.2-0.0-0.30.10.3-0.4
Reaction time mean AUC0.20.20.60.40.4-0.30.20.30.0-0.60.00.7-0.8
Median of all reaction times0.10.20.40.60.6-0.50.30.50.3-0.5-0.30.4-0.2
Reaction time omissions0.00.00.00.10.1-0.00.10.0-0.1-0.10.20.1-0.0
Reaction time false alarm rate0.40.62.4-0.7-0.70.7-0.4-0.5-0.8-0.30.30.8-1.6
Reaction time premature initiation rate0.60.71.2-0.9-0.91.0-1.0-1.0-1.10.80.7-0.5-0.1
Reaction time premature initiations0.60.91.3-1.1-1.11.0-1.0-1.1-1.10.90.9-0.6-0.1
Std. dev. reaction times0.20.21.0-0.3-0.30.2-0.3-0.3-0.6-0.30.60.6-1.0
Reaction time trials completed0.00.10.2-0.3-0.30.1-0.1-0.2-0.00.30.4-0.30.3
Reaction time trials AUC0.00.10.2-0.3-0.30.2-0.1-0.2-0.10.20.4-0.30.3
Run reversals in cocaine runway, females0.30.31.6-0.1-0.1-0.20.20.20.0-0.6-0.50.9-1.3
Run reversals in cocaine runway, males0.50.51.1-0.7-0.70.8-0.7-0.6-0.80.10.70.2-1.0
Latency to leave start box in cocaine runway0.20.20.40.50.5-0.40.60.60.6-0.3-0.60.10.3
Latency to leave start box in cocaine runway, F0.30.30.50.50.5-0.50.60.60.7-0.2-0.7-0.10.6
Latency to leave start box in cocaine runway, M0.00.00.10.10.10.00.10.10.10.10.0-0.20.4
Std. dev. time between licks in bursts0.20.30.5-0.7-0.70.6-0.5-0.6-0.50.50.3-0.3-0.1
Total sessions with >9 infusions0.10.10.3-0.4-0.40.5-0.2-0.4-0.40.20.6-0.1-0.0
Short access day 1 total inactive lever presses0.20.30.4-0.4-0.40.6-0.5-0.5-0.60.50.6-0.50.4
Short access day 10 total inactive lever presses0.30.30.70.80.8-0.70.60.50.5-0.4-0.30.20.5
Short access day 1 total infusions0.50.52.4-0.3-0.30.30.0-0.2-0.6-0.70.31.2-1.5
Short access day 10 total infusions0.91.01.5-1.2-1.21.1-0.9-1.0-1.20.51.1-0.1-0.8
Short access total infusions0.60.61.7-0.8-0.80.8-0.6-0.7-1.0-0.10.80.6-1.3
Short access day 1 locomotion0.20.30.90.10.1-0.10.50.2-0.0-0.7-0.01.0-0.9
Short access day 10 total locomotion0.50.60.90.70.7-0.70.90.70.5-1.0-0.81.0-0.4
Short access total locomotion0.30.31.00.20.2-0.20.50.30.0-0.8-0.21.0-0.8
One hour access (0.3 mA shock)1.61.92.9-1.6-1.61.6-1.3-1.4-1.60.71.7-0.0-1.1
Compulsive drug intake0.30.31.20.30.3-0.20.20.30.50.2-0.6-0.61.1
One hour access (shock baseline)1.01.22.4-1.2-1.21.2-1.0-1.0-1.30.41.50.2-1.2
Social response proportion1.61.85.1-0.6-0.60.8-1.0-1.0-0.61.81.0-2.12.3
Social responses1.21.52.9-1.1-1.11.1-1.1-1.1-0.71.60.9-1.71.4
Social time2.63.55.0-1.8-1.81.9-1.9-1.9-1.52.21.9-2.21.3
Soleus weight2.98.415.2-2.8-2.82.7-3.0-2.8-2.03.81.9-3.92.7
Bone: stiffness0.50.92.4-0.6-0.60.7-0.6-0.7-0.41.30.5-1.51.5
Tibialis anterior weight8.529.139.6-6.3-6.36.1-5.8-6.1-5.75.45.1-4.00.5
Time to tail flick, vehicle, before self-admin6.06.17.7-2.6-2.62.6-2.7-2.7-2.42.82.6-2.41.1
Time to tail flick, vehicle, after self-admin1.11.21.9-1.4-1.41.1-1.0-1.1-1.20.51.3-0.1-0.9
Time to tail flick, test, before self-admin0.50.50.8-0.8-0.80.9-0.8-0.8-0.70.70.5-0.50.1
Time to tail flick, test, after self-admin0.20.20.4-0.1-0.10.3-0.4-0.3-0.20.50.3-0.70.7
Delta time to tail flick, vehicle, before/after SA0.80.82.40.40.4-0.60.70.60.3-1.3-0.51.5-1.5
Delta time to tail flick, test, before/after SA0.10.10.2-0.2-0.20.2-0.3-0.3-0.40.10.50.1-0.2
Tibia length0.72.15.21.61.6-1.41.21.31.7-0.1-1.4-0.82.3
Ambulatory time before self-admin2.82.94.01.91.9-1.91.91.91.9-1.6-2.01.2-0.1
Ambulatory time after self-admin0.50.52.60.50.5-0.50.30.40.70.4-0.4-1.01.6
Bone: tissue strength2.72.63.71.71.7-1.81.91.81.8-1.5-1.91.10.2
Total heroin consumption3.23.85.6-1.8-1.81.9-1.9-2.0-1.62.42.0-2.31.7
Bone: trabecular number4.36.88.9-2.9-2.92.9-3.0-2.9-2.72.72.5-2.20.4
Bone: trabecular spacing0.70.91.51.01.0-1.01.21.00.8-1.1-0.71.0-0.3
Bone: trabecular thickness0.30.40.5-0.6-0.60.7-0.7-0.7-0.60.70.5-0.50.1
Bone: trabecular tissue density2.23.14.11.91.9-2.01.81.91.7-1.9-1.61.7-0.7
Water consumed over 24 hours0.50.61.60.70.7-0.70.60.70.9-0.0-0.7-0.51.3
Number of responses in last shaping day1.01.02.10.80.8-0.91.10.90.6-1.3-0.91.4-0.9