Hub : Genes

Map2k7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Map2k7 0.05 0.03 9.3e-03 0.02 0.01 0 0.01 5.0e-03 4.6e-02 2.0e-01 3.4e-02
2 Adipose gene expression Map2k7 0.06 0.04 3.8e-04 0.02 0.04 0.03 0.01 1.2e-03 4.6e-05 2.6e-04 1.5e-02
3 Liver gene expression Map2k7 0.05 0.04 2.3e-04 0.04 0.03 0.04 0.03 1.6e-05 1.2e-04 5.1e-05 7.6e-04
4 NAcc gene expression Map2k7 0.04 0.02 7.4e-06 0.04 0.04 0.03 0.03 3.4e-06 2.5e-06 5.9e-06 5.9e-06
5 IL gene expression Map2k7 0.16 0.11 2.8e-03 0.05 0.08 0.07 0.06 2.4e-02 4.7e-03 1.1e-02 1.7e-02
6 Brain gene expression Map2k7 0.07 0.04 6.9e-08 0.08 0.09 0.09 0.06 5.5e-08 5.7e-09 2.3e-08 2.8e-06
7 PL mRNA stability Map2k7 0.05 0.04 8.0e-03 0.01 0.02 0.03 0.02 3.3e-02 4.7e-03 6.0e-04 1.0e-03
8 PL gene expression Map2k7 0.04 0.03 1.3e-04 0.03 0.04 0.03 0.02 1.7e-04 7.0e-05 1.5e-04 3.7e-03
9 pVTA gene expression Map2k7 0.07 0.04 5.8e-06 0.04 0.07 0.07 0.07 5.2e-04 2.9e-06 5.3e-06 5.3e-06
10 NAcc intron excision ratio chr12_7391168_7393782 0.02 0.01 3.4e-03 0.02 0.01 0.01 0.01 1.3e-03 1.5e-02 2.8e-02 1.8e-02
11 LHb gene expression Map2k7 0.1 0.07 7.9e-03 0.06 0.07 0.07 0.04 1.5e-02 8.9e-03 9.3e-03 5.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density2.95.111.1-2.5-3.3-2.5-2.7-2.5-2.6-0.9-2.1-2.0-0.8-1.3
Area under the delay curve0.40.52.11.50.6-0.2-0.4-0.4-0.50.7-0.4-0.6-0.8-0.9
BMI with tail1.44.88.1-2.3-2.8-2.3-2.7-2.4-2.7-1.8-1.9-2.0-1.0-1.5
BMI without tail1.95.713.7-3.7-3.7-2.6-2.6-2.3-2.5-2.0-1.7-1.7-0.3-0.8
Body weight5.222.559.4-7.6-7.7-5.4-5.0-4.5-4.8-3.7-3.2-2.90.2-1.1
Weight adjusted by age0.10.20.8-0.9-0.8-0.3-0.1-0.1-0.0-0.70.10.10.40.4
Bone surface3.05.512.2-2.9-3.5-2.5-2.7-2.5-2.7-1.3-2.1-2.0-0.6-1.3
Bone volume3.05.49.1-1.9-3.0-2.5-2.9-2.7-2.9-0.8-2.3-2.4-1.3-1.9
Breakpoint value in progressive ratio session1.21.51.9-0.4-1.2-1.2-1.4-1.4-1.31.0-1.3-1.3-1.2-1.2
Number of licking bursts4.26.810.8-1.31.12.42.72.72.9-2.02.83.13.23.3
Context. condit. distance diff. score5.66.711.0-1.9-3.3-3.1-3.1-3.0-3.00.3-2.8-2.6-1.8-2.1
Locomotion velocity, session 10.10.10.40.60.3-0.0-0.0-0.1-0.00.5-0.2-0.3-0.6-0.4
Locomotion distance, session 10.40.52.11.41.10.60.50.50.50.70.30.2-0.4-0.1
Locomotion velocity, session 20.60.70.90.50.91.00.90.90.9-0.30.90.90.60.8
Locomotion distance, session 20.60.81.71.01.10.61.00.91.11.30.60.80.20.6
Locomotion velocity, session 31.21.42.2-0.4-1.2-1.5-1.4-1.4-1.40.6-1.3-1.3-1.1-1.1
Locomotion distance, session 30.10.10.3-0.1-0.3-0.5-0.3-0.3-0.30.4-0.4-0.3-0.3-0.3
Stereotopy head waving bouts, day 30.60.83.0-1.7-1.6-1.0-0.7-0.6-0.6-0.4-0.4-0.30.30.2
Stereotopy head waving duration, day 30.00.00.10.20.20.20.10.20.1-0.10.20.10.10.1
Locomotion velocity, session 70.20.20.90.90.80.50.30.30.2-0.00.20.1-0.2-0.1
Locomotion distance, session 70.10.10.30.3-0.0-0.2-0.3-0.3-0.20.4-0.4-0.3-0.5-0.4
Stereotopy head waving bouts, day 70.10.11.00.50.3-0.10.10.00.11.0-0.1-0.1-0.4-0.2
Stereotopy head waving duration, day 70.30.30.91.00.80.40.50.50.50.80.40.3-0.20.1
Locomotion velocity, session 80.10.10.6-0.2-0.1-0.0-0.00.0-0.1-0.80.10.10.10.1
Locomotion distance, session 81.01.42.8-1.0-1.7-1.4-1.4-1.4-1.4-0.2-1.2-1.1-0.6-0.8
Degree of sensitization distance0.70.71.51.01.21.20.90.90.8-0.30.80.70.30.4
Degree of sensitization stereotypy0.20.20.80.70.4-0.1-0.1-0.1-0.10.9-0.2-0.3-0.6-0.5
Conditioned locomotion0.70.81.2-0.2-0.6-0.9-1.0-1.0-1.10.8-1.0-1.0-0.9-1.1
Cocaine response after cond. corrected0.50.63.50.30.61.00.20.40.1-1.90.70.30.60.2
Cocaine response after cond. not corrected0.50.61.10.3-0.2-0.1-0.9-0.8-1.1-1.1-0.5-0.9-0.7-1.0
Cocaine response before conditioning4.75.67.5-0.1-1.9-2.7-2.5-2.6-2.42.1-2.7-2.6-2.6-2.5
Saline control response1.01.37.4-2.7-1.7-1.00.1-0.00.50.9-0.10.40.81.1
Bone: connectivity density3.45.414.1-3.2-3.8-2.6-2.6-2.4-2.5-1.1-2.0-1.8-0.3-0.9
Bone: cortical apparent density0.20.31.01.00.80.90.30.40.2-0.70.40.20.1-0.0
Bone: cortical area1.72.64.6-1.8-2.1-1.9-1.9-1.8-1.9-0.2-1.6-1.5-0.8-1.1
Bone: cortical porosity0.10.10.2-0.4-0.0-0.10.40.30.50.30.20.30.20.4
Bone: cortical porosity0.20.21.30.10.0-0.40.1-0.00.21.1-0.2-0.2-0.5-0.1
Bone: cortical thickness0.91.53.1-1.5-1.8-1.3-1.5-1.3-1.5-0.6-1.1-1.0-0.4-0.7
Bone: cortical thickness0.60.72.2-1.5-1.4-1.1-0.8-0.8-0.70.3-0.7-0.6-0.1-0.2
Bone: cortical tissue density0.30.41.11.10.91.00.40.50.3-0.70.50.30.20.1
Condit. Reinf. active minus inactive responses0.30.31.21.10.50.0-0.3-0.3-0.40.4-0.4-0.6-0.8-0.8
Condit. Reinf. active-inactive response ratio0.40.40.90.70.0-0.2-0.6-0.6-0.7-0.0-0.6-0.8-0.9-1.0
Condit. Reinf. active responses0.60.72.01.00.0-0.6-0.5-0.6-0.51.4-0.8-0.8-1.2-1.0
Condit. Reinf. inactive responses0.60.74.50.90.2-0.6-0.1-0.3-0.02.1-0.5-0.4-0.9-0.5
Incentive salience index mean0.91.12.41.0-0.0-0.6-0.8-0.9-0.81.5-1.0-1.1-1.4-1.3
Condit. Reinf. lever presses1.31.84.80.8-0.4-1.1-1.1-1.2-1.12.2-1.4-1.4-1.7-1.5
Condit. Reinf. active minus inactive responses0.30.41.6-1.2-1.0-0.7-0.5-0.5-0.4-0.0-0.4-0.20.10.1
Condit. Reinf. active-inactive response ratio0.10.10.3-0.6-0.10.10.30.30.40.20.30.40.40.5
Condit. Reinf. active responses1.31.83.2-1.5-1.8-1.6-1.5-1.5-1.40.6-1.5-1.2-0.8-0.9
Condit. Reinf. inactive responses1.62.02.7-1.0-1.6-1.6-1.6-1.6-1.50.8-1.6-1.5-1.2-1.3
Condit. Reinf. lever presses1.92.73.7-0.3-1.5-1.9-1.8-1.8-1.81.1-1.8-1.8-1.7-1.7
Condit. Reinf. lever reinforcers received0.91.32.1-1.1-1.5-1.3-1.2-1.3-1.10.8-1.3-1.1-0.8-0.8
Conditioned reinforcement - actives0.81.47.6-2.7-2.0-1.2-0.8-0.7-0.6-0.5-0.4-0.10.80.4
Conditioned reinforcement - inactives0.50.81.7-1.0-0.00.60.80.80.9-0.40.81.01.31.2
Conditioned locomotion2.33.06.6-2.2-2.6-2.1-1.8-1.8-1.61.0-1.8-1.4-0.9-0.9
Patch foraging indifference point 0 sec0.00.10.5-0.7-0.3-0.2-0.2-0.2-0.2-0.1-0.2-0.20.1-0.1
Patch foraging indifference point AUC0.40.52.7-1.6-0.7-0.10.10.20.2-0.80.30.51.00.8
Delay disc. indifference point, 0s delay0.30.33.2-0.00.1-0.2-0.3-0.1-0.4-1.80.2-0.10.2-0.2
Delay disc. indifference point, 16s delay0.10.10.60.80.3-0.2-0.2-0.2-0.30.6-0.2-0.2-0.3-0.4
Delay disc. indifference point, 2s delay1.82.04.51.90.5-0.6-1.1-1.2-1.30.9-1.3-1.7-2.1-2.1
Delay disc. indifference point, 24s delay0.50.51.31.01.20.80.70.70.60.30.70.70.30.3
Delay disc. indifference point, 4s delay1.21.32.61.40.2-0.6-1.0-1.0-1.10.8-1.1-1.3-1.6-1.6
Delay disc. indifference point, 8s delay0.40.51.41.20.2-0.4-0.3-0.4-0.41.2-0.5-0.5-0.7-0.7
Indifference point function ln k0.10.21.3-0.3-0.3-0.50.20.10.41.2-0.00.1-0.10.3
Indifference point function log k0.10.21.3-0.3-0.3-0.50.20.10.41.2-0.00.1-0.10.3
Patch foraging total patch changes 0 sec0.00.10.5-0.7-0.4-0.2-0.2-0.2-0.20.2-0.3-0.20.1-0.1
Patch foraging total patch changes 12 sec0.20.21.0-1.0-0.6-0.4-0.4-0.4-0.4-0.7-0.3-0.20.2-0.1
Patch foraging total patch changes 18 sec0.30.40.9-1.0-0.00.70.40.40.4-0.90.40.60.80.7
Patch foraging total patch changes 24 sec0.30.51.2-0.8-0.6-0.8-0.5-0.6-0.41.1-0.8-0.5-0.5-0.5
Patch foraging total patch changes 6 sec0.20.31.2-1.1-0.8-0.5-0.5-0.5-0.4-0.3-0.5-0.3-0.0-0.2
Patch foraging time to switch 0 sec0.81.76.72.62.01.70.40.60.1-1.80.80.1-0.2-0.5
Patch foraging water rate 0 sec1.02.19.0-3.0-2.5-1.8-0.7-0.9-0.31.4-1.0-0.30.30.4
Patch foraging water rate 12 sec0.51.15.2-1.0-1.2-1.4-0.6-0.8-0.32.3-1.0-0.6-0.5-0.3
Patch foraging water rate 18 sec0.91.48.80.2-0.7-1.3-0.5-0.7-0.33.0-1.1-0.8-1.2-0.6
Patch foraging water rate 24 sec0.91.33.9-1.6-2.0-1.6-0.6-0.8-0.31.6-0.9-0.5-0.20.2
Patch foraging water rate 6 sec1.92.76.0-1.0-1.8-2.2-1.5-1.6-1.22.4-1.8-1.5-1.3-1.1
Seeking ratio, delayed vs. immediate footshock3.54.27.61.32.52.82.32.32.2-0.72.12.11.81.6
Distance traveled before self-admin0.40.51.51.10.5-0.1-0.2-0.3-0.31.2-0.5-0.6-1.0-0.8
Distance traveled after self-admin0.50.61.5-0.1-0.5-0.7-0.7-0.7-0.71.2-0.9-0.7-0.8-0.8
Extensor digitorum longus weight3.714.733.1-4.8-5.8-4.8-4.3-4.2-4.1-0.1-3.6-3.2-1.5-2.0
Bone: elastic displacement0.10.10.8-0.9-0.6-0.6-0.1-0.10.0-0.1-0.10.10.20.3
Bone: elastic work1.92.48.2-2.9-2.6-2.1-1.4-1.4-1.2-0.6-1.1-0.9-0.1-0.2
Bone: endosteal estimation0.40.85.3-2.3-1.3-0.9-0.2-0.20.0-0.2-0.10.20.70.6
Bone: endosteal perimeter1.32.75.4-2.1-2.3-2.2-1.7-1.8-1.50.6-1.7-1.5-0.9-1.0
Epididymis fat weight0.62.22.9-0.0-1.1-1.5-1.7-1.7-1.71.0-1.7-1.7-1.7-1.7
Delta time in closed arm before/after self-admin0.10.10.4-0.6-0.60.0-0.1-0.20.00.2-0.2-0.10.00.1
Delta time in open arm before/after self-admin1.01.05.72.41.30.50.0-0.0-0.10.7-0.2-0.5-1.1-1.0
Diff in mean of infusions in LGA sessions0.50.71.7-0.7-0.9-1.3-0.8-0.8-0.70.8-0.8-0.7-0.6-0.6
Delay discount exponential model param0.70.82.8-1.7-0.60.30.50.50.6-1.10.60.81.11.1
Extinction: sum of active levers before priming0.91.01.80.6-0.3-0.6-1.1-1.0-1.20.7-1.0-1.1-1.2-1.3
Active lever presses in extinction session 60.60.61.0-0.6-0.9-0.6-1.0-0.9-1.00.2-0.8-0.8-0.6-0.7
Bone: final force0.71.16.9-2.6-1.6-0.8-0.4-0.3-0.2-0.9-0.00.20.90.7
Bone: final moment0.61.05.7-2.4-1.3-0.6-0.1-0.1-0.0-0.90.10.31.00.8
Food consumed during 24 hour testing period0.50.61.3-0.40.10.60.90.91.0-0.20.81.01.01.2
Glucose0.40.62.91.71.50.60.50.50.30.20.40.2-0.3-0.3
Heart weight0.20.31.2-1.1-0.9-0.8-0.1-0.20.10.6-0.4-0.00.10.3
Delay discount hyperbolic model param0.70.82.5-1.6-0.50.30.60.60.7-1.00.70.91.21.2
Intermittent access intake day 1-15 change0.61.22.9-1.6-0.40.50.60.70.7-1.40.91.11.71.4
Intermittent access intake escalation0.71.33.2-1.6-0.30.50.70.80.8-1.41.11.21.81.5
Intermittent access intake escalation 20.91.01.6-0.40.61.20.91.00.9-1.11.11.21.31.1
Intermitt. access day 1 inactive lever presses0.20.91.9-0.60.40.51.01.01.0-0.61.01.21.41.2
Intermitt. access day 15 inactive lever presses0.10.31.60.60.50.50.10.30.0-1.30.50.10.30.0
Intermitt. access escalation Index0.50.71.80.4-0.4-0.7-0.6-0.7-0.51.3-0.9-0.8-1.1-0.8
Intermittent access day 1 total infusions0.30.52.80.60.2-0.4-0.1-0.3-0.11.7-0.5-0.4-0.8-0.5
Intermittent access day 15 total infusions0.10.10.4-0.5-0.2-0.30.10.00.10.6-0.10.20.20.2
Intermittent access terminal intake (last 3 days)0.00.10.1-0.10.10.40.20.20.20.20.20.30.20.2
Intermittent access total infusions0.20.20.60.3-0.1-0.2-0.3-0.4-0.30.8-0.5-0.4-0.6-0.5
Intermittent access day 1 locomotion1.62.04.90.9-0.3-1.3-1.1-1.2-1.02.2-1.5-1.5-2.0-1.6
Intermittent access day 15 total locomotion1.01.85.5-0.8-1.3-1.8-1.0-1.2-0.82.3-1.5-1.1-1.2-0.8
Intermittent access total locomotion1.51.84.90.4-0.6-1.3-1.0-1.2-1.02.2-1.5-1.3-1.7-1.3
Intermittent access standard deviation0.61.23.1-0.30.61.30.81.00.7-1.81.21.11.51.1
Left kidney weight3.014.245.9-6.8-6.5-4.3-3.5-3.2-3.2-2.6-2.2-1.80.8-0.1
Right kidney weight2.29.833.8-5.8-5.5-3.5-2.7-2.4-2.4-2.8-1.5-1.21.10.4
Cocaine induced anxiety1.01.42.30.4-0.6-0.9-1.3-1.3-1.40.9-1.3-1.4-1.4-1.5
Post-drug Anxiety1.51.66.62.61.20.5-0.8-0.7-1.00.1-0.6-1.2-1.6-1.8
Baseline Anxiety2.73.27.32.62.72.51.61.71.4-1.41.81.20.70.6
Tail length2.810.739.8-6.3-5.7-3.8-2.8-2.5-2.4-2.6-1.7-1.21.10.4
Length with tail4.921.578.6-8.9-8.1-5.1-4.0-3.6-3.6-3.6-2.4-1.71.80.5
Length without tail2.99.233.3-5.8-5.2-3.1-2.5-2.2-2.3-3.1-1.3-0.91.60.5
Times rat made contact with spout0.40.41.8-1.4-0.7-0.00.40.30.6-0.30.30.50.70.9
Lifetime Intake0.10.20.50.70.30.1-0.2-0.2-0.20.6-0.3-0.3-0.6-0.5
Liver weight, left1.52.48.0-2.8-1.50.20.40.60.6-2.40.91.12.11.9
Liver weight, right0.91.54.7-2.0-2.2-1.3-1.2-1.2-1.1-0.6-0.9-0.8-0.1-0.2
Locomotor activity0.91.44.9-1.8-2.2-1.6-1.0-1.1-0.80.3-1.0-0.7-0.3-0.1
Locomotor testing distance0.20.31.5-1.1-1.2-0.6-0.2-0.3-0.0-0.3-0.2-0.00.30.5
Locomotor testing rearing0.00.00.10.0-0.30.0-0.1-0.10.0-0.3-0.2-0.3-0.3-0.0
Locomotion in novel chamber0.50.73.2-1.8-0.9-0.60.30.20.50.90.00.50.90.9
Locomotion in novel chamber post-restriction0.71.12.8-1.7-1.6-1.7-0.5-0.7-0.31.5-0.9-0.40.30.1
Fecal boli incidents, locomotor time 10.91.43.9-1.9-2.0-1.6-1.0-1.1-0.80.8-1.0-0.7-0.1-0.2
Change in fecal boli incidents, locomotor task1.21.22.40.81.21.31.01.10.8-1.61.21.00.90.8
Time >=10cm from walls, locomotor time 11.11.22.81.20.1-0.6-0.9-1.0-1.10.5-1.0-1.3-1.7-1.5
Bouts of movement, locomotor time 10.40.51.8-1.3-1.4-1.0-0.5-0.5-0.4-0.1-0.4-0.10.40.3
Total resting periods, locomotor time 10.50.62.1-1.3-1.4-1.0-0.6-0.6-0.5-0.0-0.5-0.30.20.1
Rest time, locomotor task time 10.91.23.4-1.1-1.9-1.4-1.2-1.2-1.1-0.4-0.9-0.9-0.2-0.4
Distance moved, locomotor task time 10.20.31.00.61.00.80.60.60.60.60.40.4-0.00.1
Vertical activity count, locomotor time 10.00.10.1-0.20.20.40.30.30.30.30.10.40.40.3
Time >=10cm from walls, locomotor time 21.52.33.6-0.3-1.3-1.7-1.8-1.7-1.9-0.3-1.5-1.8-1.5-1.7
Bouts of movement, locomotor time 21.11.83.3-0.8-1.8-1.8-1.5-1.5-1.40.9-1.4-1.3-0.9-0.9
Total resting periods, locomotor time 20.81.42.9-0.7-1.7-1.7-1.3-1.3-1.30.5-1.2-1.1-0.7-0.8
Rest time, locomotor task time 20.50.71.20.6-0.6-0.9-0.8-0.8-0.70.7-0.9-1.0-1.1-0.9
Distance moved, locomotor task time 21.82.23.2-0.61.01.51.61.61.6-1.21.61.71.81.7
Vertical activity count, locomotor time 21.21.64.2-2.1-0.30.40.80.90.9-1.01.01.42.01.7
Light reinforcement 10.30.72.41.50.90.0-0.3-0.3-0.41.1-0.5-0.6-1.0-1.0
Light reinforcement 20.50.81.30.81.11.01.01.01.0-0.10.91.00.70.7
Bone: marrow area0.40.85.1-2.3-1.3-0.9-0.1-0.10.1-0.2-0.10.20.70.7
Bone: maximum diameter1.02.04.2-1.9-2.1-1.8-1.5-1.5-1.5-0.1-1.2-1.2-0.5-0.7
Bone: maximum force0.81.46.6-2.6-2.0-1.4-0.9-0.9-0.8-0.6-0.7-0.40.30.1
Bone: maximum moment0.61.15.6-2.4-1.8-1.3-0.7-0.6-0.5-0.5-0.5-0.20.40.3
Mean time between licks in bursts0.20.41.21.11.00.20.40.30.41.00.0-0.0-0.6-0.3
Mean num. licks in bursts1.82.73.80.2-1.2-1.8-1.8-1.8-1.71.3-1.8-2.0-1.9-1.9
Cd content in liver0.40.54.2-0.30.0-0.50.30.10.42.1-0.20.1-0.20.1
Co content in liver2.42.74.6-0.90.81.41.91.82.1-0.41.72.01.92.1
Cu content in liver0.10.10.8-0.3-0.2-0.2-0.1-0.2-0.10.9-0.3-0.2-0.3-0.2
Fe content in liver5.66.88.7-0.9-2.5-2.9-2.9-2.9-2.82.3-3.0-2.8-2.6-2.6
K content in liver0.40.40.80.5-0.2-0.5-0.7-0.7-0.70.4-0.7-0.7-0.9-0.9
Mg content in liver0.10.10.2-0.3-0.10.10.30.30.3-0.10.30.40.40.4
Mn content in liver1.71.82.70.81.31.61.51.51.5-0.81.51.51.31.4
Na content in liver0.30.31.2-1.1-0.9-0.5-0.6-0.5-0.5-0.5-0.3-0.30.2-0.1
Rb content in liver1.21.44.32.11.20.3-0.3-0.4-0.51.7-0.7-0.9-1.8-1.5
Se content in liver5.97.011.2-0.3-2.1-2.5-3.2-3.1-3.30.4-2.9-3.1-2.7-3.1
Sr content in liver1.81.52.8-0.50.51.11.21.21.2-1.51.41.41.71.5
Zn content in liver0.80.95.2-2.3-1.5-0.8-0.4-0.3-0.3-0.3-0.20.10.70.6
Bone: minimum diameter0.10.20.5-0.70.20.20.40.40.5-0.40.30.30.30.4
Time in familiar zone, hab. session 10.70.61.30.50.81.00.80.80.7-1.20.90.60.60.6
Time in novel zone, hab. session 10.20.20.5-0.7-0.6-0.5-0.5-0.5-0.50.3-0.4-0.3-0.1-0.2
Total zone transitions, hab. session 10.40.62.31.40.90.30.10.00.01.5-0.3-0.2-0.8-0.6
Total locomotion distance, hab. session 11.01.42.61.40.2-0.5-1.0-1.0-1.21.4-1.1-1.2-1.6-1.6
Locomotion velocity, hab. session 11.11.53.81.90.7-0.3-0.7-0.8-0.91.8-1.0-1.1-1.6-1.6
Time in familiar zone, hab. session 20.10.10.50.40.20.2-0.1-0.1-0.2-0.70.0-0.2-0.1-0.2
Time in novel zone, hab. session 20.10.10.60.10.2-0.00.10.10.20.8-0.10.0-0.2-0.0
Total zone transitions, hab. session 20.60.71.3-0.60.30.60.90.91.0-0.60.91.11.11.1
Total locomotion distance, hab. session 20.10.10.20.30.40.20.30.30.30.50.20.20.00.1
Locomotion velocity, hab. session 20.10.20.30.30.60.40.50.50.50.40.30.50.30.3
Novel to familiar place preference ratio0.70.81.10.10.60.81.01.01.1-0.71.01.00.81.0
Novelty place preference0.80.91.40.40.91.01.11.11.2-0.51.01.00.71.0
Time in novel zone, NPP test0.60.71.00.20.70.81.00.91.0-0.70.90.90.70.9
Total zone transitions, NPP test0.00.00.2-0.4-0.3-0.1-0.1-0.1-0.10.4-0.2-0.1-0.1-0.0
Total locomotion distance, NPP test1.52.03.00.3-0.8-1.3-1.5-1.5-1.51.4-1.6-1.6-1.7-1.7
Locomotion velocity, NPP test1.41.93.40.1-0.9-1.4-1.4-1.5-1.31.8-1.6-1.5-1.6-1.5
Intraocular pressure2.02.95.4-1.7-2.3-2.1-1.9-1.9-1.71.1-1.8-1.6-0.9-1.1
Delta distance traveled before/after self-admin0.40.41.0-0.9-0.20.30.40.40.4-0.60.50.71.00.8
Delta ambulatory time before/after self-admin0.30.40.60.00.50.80.70.70.7-0.40.60.70.70.7
Parametrial fat weight0.10.31.4-0.0-0.1-0.2-0.6-0.4-0.8-1.2-0.1-0.5-0.3-0.6
Pavlov. Cond. lever latency0.81.13.2-1.8-1.00.00.30.40.4-1.70.60.71.41.2
Pavlov. Cond. magazine entry latency0.20.30.8-0.4-0.9-0.8-0.6-0.6-0.50.4-0.6-0.5-0.3-0.3
Pavlov. Cond. change in total contacts0.50.51.81.30.4-0.1-0.5-0.5-0.60.4-0.5-0.7-0.9-1.0
Pavlov. Cond. index score0.50.71.10.6-0.2-0.7-0.8-0.8-0.81.0-0.9-0.9-1.0-1.0
Pavlov. Cond. latency score0.60.71.40.8-0.0-0.6-0.7-0.7-0.71.2-0.8-0.9-1.1-1.1
Pavlov. Cond. lever contacts0.70.92.81.70.90.0-0.3-0.3-0.41.4-0.6-0.7-1.3-1.1
Pavlov. Cond. magazine entry number0.81.11.70.21.11.31.11.11.0-1.11.21.11.00.9
Pavlov. Cond. intertrial magazine entries0.40.51.11.11.00.60.90.70.90.80.50.5-0.00.3
Pavlov. Cond. lever-magazine prob. diff.0.50.61.00.7-0.2-0.7-0.7-0.8-0.80.9-0.8-0.9-1.0-1.0
Pavlov. Cond. response bias0.70.91.30.1-0.8-1.0-1.0-1.0-0.91.1-1.1-1.0-1.0-1.0
Pavlov. Cond. lever latency1.11.52.2-0.50.61.21.21.31.2-1.51.41.41.51.4
Pavlov. Cond. magazine entry latency1.01.33.61.90.5-0.4-0.6-0.7-0.71.5-0.9-1.0-1.5-1.4
Pavlov. Cond. change in total contacts0.40.62.60.4-0.3-0.8-0.6-0.7-0.51.6-0.8-0.7-0.9-0.8
Pavlov. Cond. index score1.01.33.91.20.1-0.8-0.8-0.9-0.82.0-1.1-1.1-1.5-1.4
Pavlov. Cond. latency score1.01.43.51.20.0-0.8-0.8-0.9-0.91.9-1.1-1.2-1.5-1.4
Pavlov. Cond. lever contacts1.62.23.30.7-0.6-1.4-1.4-1.5-1.41.7-1.6-1.7-1.8-1.7
Pavlov. Cond. magazine entry number0.70.93.1-1.8-0.70.10.30.30.3-1.70.60.61.11.0
Pavlov. Cond. intertrial magazine entries0.20.42.2-1.5-0.8-0.10.10.10.3-0.40.10.30.60.7
Pavlov. Cond. lever-magazine prob. diff.0.91.24.31.30.2-0.7-0.7-0.8-0.72.1-1.0-1.0-1.4-1.3
Pavlov. Cond. response bias2.12.95.61.2-0.4-1.5-1.5-1.6-1.52.4-1.8-1.8-2.2-2.0
Time in closed arm before self-admin0.81.03.6-1.9-0.5-0.40.50.60.6-0.40.71.11.51.4
Time in closed arm after self-admin0.90.94.5-2.1-1.0-0.40.50.40.70.20.30.91.11.3
Time in open arm before self-admin0.10.20.3-0.1-0.4-0.4-0.4-0.4-0.30.5-0.5-0.4-0.4-0.4
Time in open arm after self-admin0.70.72.91.70.60.2-0.5-0.5-0.60.3-0.5-0.9-1.1-1.2
Bone: periosteal estimation0.81.76.9-2.6-2.1-1.7-1.1-1.1-1.0-0.3-0.9-0.70.1-0.1
Bone: periosteal perimeter2.44.16.6-1.5-2.3-2.6-2.2-2.2-2.11.3-2.2-2.1-1.7-1.7
Bone: post-yield work1.11.62.3-0.7-1.4-1.5-1.4-1.5-1.40.8-1.5-1.4-1.1-1.2
Progressive ratio test 1 active lever presses0.20.31.8-1.3-0.9-0.4-0.3-0.2-0.2-0.3-0.10.10.50.3
Progressive ratio test 1 breakpoint0.20.31.8-1.3-0.8-0.4-0.2-0.2-0.2-0.3-0.10.10.50.3
Progressive ratio test 1 inactive lever presses0.50.72.2-1.5-0.4-0.10.60.60.8-0.00.60.91.21.2
Progressive ratio test 2 active lever presses0.40.52.4-1.5-0.6-0.10.30.30.4-0.10.40.71.10.9
Progressive ratio test 2 breakpoint0.40.52.1-1.5-0.5-0.10.30.30.4-0.10.40.71.00.9
Progressive ratio test 2 inactive lever presses0.81.27.2-2.7-1.9-1.1-0.2-0.30.00.0-0.20.20.90.9
Incentive Sensitization - Responses0.20.30.4-0.00.40.60.60.60.5-0.20.60.60.60.5
Incentive Sensitization - Breakpoint0.20.20.30.10.50.60.50.50.5-0.10.50.60.50.5
Sum of active levers in priming session hrs 5-60.70.61.70.1-0.3-0.5-1.1-0.9-1.3-0.5-0.7-0.9-0.6-1.1
Progressive ratio1.21.92.80.61.61.61.71.61.6-0.31.51.41.01.2
Food seeking constrained by brief footshock0.60.71.50.81.21.21.00.90.9-0.10.80.70.50.5
Seeking ratio, punishment vs. effort0.40.51.3-0.8-1.1-0.8-0.9-0.8-0.9-0.2-0.7-0.6-0.2-0.4
Retroperitoneal fat weight0.72.95.61.2-0.4-1.1-2.0-1.8-2.2-0.2-1.6-2.1-2.1-2.4
Reaction time number correct0.20.42.1-1.4-0.7-0.30.10.10.20.50.10.40.60.7
Reaction time mean minus median1.84.56.30.0-1.7-2.3-2.2-2.3-2.11.5-2.4-2.5-2.5-2.3
Reaction time mean minus median AUC0.71.83.50.7-0.7-1.4-1.0-1.2-0.91.9-1.5-1.4-1.9-1.4
Reaction time num false alarms0.50.81.7-0.0-0.6-0.9-0.7-0.8-0.61.1-1.0-1.0-1.3-0.9
Reaction time num false alarms AUC0.91.52.5-0.3-0.9-1.3-1.1-1.3-1.01.2-1.4-1.4-1.6-1.2
Reaction time trials correct on left0.20.42.1-1.4-0.7-0.30.10.10.20.50.10.40.60.7
Reaction time trials on left0.20.31.9-1.4-0.7-0.30.10.10.20.50.10.40.50.7
Reaction time mean0.71.17.82.81.50.60.20.20.10.4-0.0-0.4-1.1-0.8
Reaction time mean AUC0.81.27.92.81.40.50.10.0-0.00.6-0.2-0.5-1.3-1.0
Median of all reaction times1.52.211.43.42.41.61.11.00.9-0.10.90.5-0.4-0.2
Reaction time omissions0.60.92.01.40.0-0.7-0.6-0.7-0.51.2-0.9-1.0-1.4-1.1
Reaction time false alarm rate1.21.73.30.4-0.7-1.2-1.2-1.3-1.21.0-1.5-1.6-1.8-1.6
Reaction time premature initiation rate0.10.20.50.4-0.1-0.2-0.4-0.4-0.40.5-0.5-0.5-0.7-0.5
Reaction time premature initiations0.10.10.4-0.2-0.3-0.3-0.3-0.3-0.20.7-0.4-0.2-0.4-0.2
Std. dev. reaction times1.01.94.01.1-0.4-1.1-1.2-1.3-1.21.1-1.5-1.7-2.0-1.7
Reaction time trials completed0.20.31.9-1.4-0.7-0.30.10.10.20.50.10.40.50.7
Reaction time trials AUC0.10.31.5-1.2-0.7-0.40.0-0.00.10.7-0.10.20.30.5
Run reversals in cocaine runway, females0.30.31.11.10.5-0.0-0.3-0.3-0.40.3-0.3-0.4-0.6-0.7
Run reversals in cocaine runway, males0.40.41.2-0.30.20.20.80.71.01.10.40.70.40.8
Latency to leave start box in cocaine runway0.40.40.90.80.70.60.50.60.4-1.00.70.60.50.4
Latency to leave start box in cocaine runway, F1.11.34.20.30.71.10.81.00.7-2.01.31.21.41.1
Latency to leave start box in cocaine runway, M0.30.30.80.60.2-0.4-0.2-0.3-0.10.9-0.4-0.4-0.8-0.5
Std. dev. time between licks in bursts0.60.91.8-0.8-1.0-1.3-0.8-0.9-0.61.3-1.0-0.8-0.8-0.6
Total sessions with >9 infusions0.30.30.70.60.90.80.60.60.5-0.40.60.50.20.3
Short access day 1 total inactive lever presses0.10.20.3-0.30.00.50.40.40.5-0.60.50.40.50.5
Short access day 10 total inactive lever presses0.51.25.5-1.6-0.60.40.20.40.2-2.30.80.71.51.1
Short access day 1 total infusions0.40.51.81.31.20.90.60.60.5-0.30.60.3-0.1-0.0
Short access day 10 total infusions0.50.61.40.8-0.0-0.3-0.7-0.7-0.80.7-0.8-0.9-1.2-1.1
Short access total infusions0.40.52.11.51.11.00.30.30.1-0.30.40.1-0.3-0.3
Short access day 1 locomotion0.30.41.40.60.0-0.4-0.3-0.4-0.31.2-0.6-0.7-1.0-0.7
Short access day 10 total locomotion0.00.00.1-0.0-0.2-0.20.0-0.10.10.4-0.1-0.1-0.40.0
Short access total locomotion0.40.41.41.20.4-0.0-0.3-0.3-0.30.8-0.4-0.6-1.1-0.8
One hour access (0.3 mA shock)0.70.83.5-1.9-0.9-0.30.50.30.70.70.20.71.01.2
Compulsive drug intake0.91.13.01.61.70.81.21.11.10.60.90.80.30.4
One hour access (shock baseline)0.81.34.4-2.1-2.0-1.2-0.9-1.0-0.70.8-1.0-0.6-0.2-0.1
Social response proportion1.01.16.1-2.5-1.7-0.8-0.4-0.3-0.3-0.9-0.10.21.10.7
Social responses1.51.94.7-2.1-2.2-1.8-1.3-1.4-1.20.6-1.3-1.0-0.5-0.5
Social time1.01.43.41.81.91.51.31.21.30.80.90.80.00.4
Soleus weight1.85.49.7-2.4-3.1-2.9-2.7-2.6-2.60.8-2.4-2.2-1.2-1.6
Bone: stiffness0.40.71.8-1.4-1.2-1.1-0.7-0.8-0.60.6-0.8-0.6-0.2-0.3
Tibialis anterior weight4.013.632.7-4.7-5.7-4.5-4.2-4.0-4.0-0.8-3.3-3.0-1.2-1.8
Time to tail flick, vehicle, before self-admin0.30.31.81.41.10.60.10.2-0.1-0.30.30.1-0.2-0.4
Time to tail flick, vehicle, after self-admin0.00.00.00.10.10.20.10.00.00.2-0.00.1-0.0-0.0
Time to tail flick, test, before self-admin1.01.02.9-1.7-0.6-0.00.50.60.5-1.40.80.91.51.3
Time to tail flick, test, after self-admin0.20.20.80.90.90.40.20.30.0-0.60.40.20.0-0.1
Delta time to tail flick, vehicle, before/after SA0.10.10.6-0.2-0.3-0.3-0.2-0.3-0.10.8-0.4-0.3-0.3-0.2
Delta time to tail flick, test, before/after SA0.50.62.71.60.90.3-0.1-0.2-0.30.7-0.3-0.5-1.0-0.9
Tibia length1.43.912.3-3.5-1.80.10.30.50.4-3.41.11.32.82.1
Ambulatory time before self-admin1.11.73.00.5-0.5-1.1-1.2-1.3-1.21.7-1.4-1.5-1.7-1.5
Ambulatory time after self-admin0.70.91.40.2-0.5-0.8-0.9-1.0-0.91.2-1.1-1.0-1.1-1.1
Bone: tissue strength0.40.41.40.00.30.50.60.60.6-1.20.70.70.80.7
Total heroin consumption2.02.45.02.00.4-0.3-1.1-1.2-1.22.2-1.5-1.6-2.2-2.0
Bone: trabecular number2.13.48.1-2.1-2.8-1.9-2.2-2.0-2.1-1.2-1.6-1.6-0.4-1.0
Bone: trabecular spacing1.31.75.22.22.31.31.31.21.31.20.80.7-0.30.1
Bone: trabecular thickness4.96.111.2-2.2-3.3-3.0-3.0-2.8-2.90.1-2.5-2.4-1.3-1.8
Bone: trabecular tissue density0.81.21.60.3-0.7-1.2-1.2-1.2-1.20.8-1.2-1.2-1.3-1.2
Water consumed over 24 hours1.52.04.7-2.2-0.80.51.11.01.3-1.11.11.42.02.0
Number of responses in last shaping day0.10.10.40.70.40.40.10.10.10.30.1-0.1-0.4-0.2