Hub : Genes

Stx5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Stx5	0.07	0.04	4.6e-07	0.05	0.04	0.04	0.04	3.0e-06	1.2e-05	1.0e-05	1.4e-05
2	Adipose	isoform ratio	NM_031704.2	0.03	0.02	3.8e-03	0	0	0	0	8.1e-02	7.5e-02	1.7e-01	2.2e-01
3	Adipose	alternative TSS	NM_031704.2	0.04	0.03	1.3e-03	0.01	0.01	0	0	4.1e-02	2.9e-02	8.3e-02	1.1e-01
4	PL	mRNA stability	Stx5	0.07	0.04	1.0e-09	0.1	0.09	0.1	0.1	1.7e-10	3.0e-10	7.2e-11	5.5e-11
5	Adipose	mRNA stability	Stx5	0.19	0.08	0.0e+00	0.08	0.13	0.13	0.12	6.1e-09	2.2e-14	2.0e-14	1.1e-13
6	Adipose	alternative TSS	XM_006230997.4	0.04	0.03	7.4e-04	0.01	0.01	0	0.01	1.0e-02	2.4e-02	8.7e-02	6.7e-02
7	Adipose	isoform ratio	XM_006230997.4	0.03	0.02	1.7e-03	0.01	0.01	0.01	0	2.7e-02	4.8e-02	6.6e-02	1.4e-01
8	Brain	mRNA stability	Stx5	0.08	0.04	1.2e-06	0.03	0.07	0.06	0.05	7.9e-04	8.0e-07	4.9e-06	1.3e-05
9	BLA	mRNA stability	Stx5	0.08	0.05	9.3e-04	0.06	0.06	0.05	0.06	3.3e-04	7.3e-04	1.1e-03	5.6e-04
10	NAcc	mRNA stability	Stx5	0.1	0.05	0.0e+00	0.14	0.12	0.12	0.13	2.6e-20	1.6e-17	3.6e-18	2.5e-19
11	OFC	mRNA stability	Stx5	0.18	0.12	8.3e-03	0.02	0.07	0.07	0.04	1.1e-01	8.4e-03	8.9e-03	3.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.4	0.7	1.7	0.6	0.5	0.5	-0.8	-1.3	-0.8	-0.8	-0.2	-0.7	-0.7	-1.2
Area under the delay curve	0.0	0.0	0.2	0.1	0.1	0.1	-0.1	-0.4	-0.1	-0.1	0.2	-0.2	-0.1	-0.5
BMI with tail	2.3	7.9	16.8	2.7	2.2	2.1	-2.7	-4.1	-2.8	-2.8	0.5	-2.8	-2.7	-4.1
BMI without tail	0.4	1.3	2.9	1.2	1.0	1.0	-1.0	-1.5	-1.0	-1.0	0.9	-1.2	-1.0	-1.7
Body weight	3.2	13.9	19.8	4.0	3.5	3.4	-3.8	-4.4	-3.8	-3.8	2.0	-3.8	-3.7	-4.5
Weight adjusted by age	0.7	1.1	1.5	1.1	0.9	0.9	-1.2	-1.2	-1.1	-1.1	0.2	-1.0	-1.0	-1.1
Bone surface	2.4	4.3	8.1	2.1	1.7	1.6	-2.1	-2.8	-2.2	-2.2	0.1	-2.1	-2.1	-2.5
Bone volume	1.1	1.9	4.9	1.3	0.9	0.8	-1.4	-2.2	-1.4	-1.4	-0.5	-1.3	-1.3	-1.8
Breakpoint value in progressive ratio session	2.1	2.5	3.3	1.6	1.8	1.8	-1.7	-1.2	-1.7	-1.7	1.2	-1.7	-1.7	-1.1
Number of licking bursts	0.0	0.0	0.0	0.2	0.0	0.0	-0.2	-0.2	0.0	0.0	0.0	0.1	0.1	-0.1
Context. condit. distance diff. score	0.3	0.4	0.8	-0.9	-0.7	-0.7	0.8	0.3	0.7	0.7	-0.3	0.5	0.5	0.2
Locomotion velocity, session 1	0.1	0.1	0.4	-0.3	0.0	0.0	0.2	0.2	0.1	0.1	0.7	-0.1	-0.1	-0.1
Locomotion distance, session 1	0.5	0.6	1.2	0.4	0.7	0.7	-0.5	-0.8	-0.6	-0.6	0.7	-0.9	-1.0	-1.1
Locomotion velocity, session 2	2.5	2.9	4.0	1.7	1.7	1.7	-1.7	-1.7	-1.6	-1.6	1.0	-2.0	-2.0	-1.8
Locomotion distance, session 2	0.2	0.2	0.6	0.3	0.5	0.5	-0.3	-0.2	-0.3	-0.3	0.8	-0.6	-0.6	-0.5
Locomotion velocity, session 3	0.3	0.4	1.6	0.4	0.3	0.2	-0.4	-1.2	-0.3	-0.3	0.0	-0.5	-0.5	-1.3
Locomotion distance, session 3	0.1	0.1	0.3	0.3	0.3	0.3	-0.2	-0.2	-0.2	-0.2	0.6	-0.1	-0.1	-0.3
Stereotopy head waving bouts, day 3	0.3	0.3	0.9	-0.6	-0.6	-0.7	0.6	-0.5	0.5	0.5	-0.9	0.2	0.2	-0.5
Stereotopy head waving duration, day 3	0.2	0.2	0.3	-0.6	-0.5	-0.5	0.5	-0.2	0.5	0.5	-0.6	0.1	0.1	-0.3
Locomotion velocity, session 7	0.1	0.1	0.2	-0.2	-0.2	-0.2	0.2	-0.4	0.2	0.2	-0.5	-0.1	-0.1	-0.4
Locomotion distance, session 7	0.1	0.1	0.2	-0.3	-0.3	-0.2	0.3	0.0	0.4	0.4	0.1	0.2	0.2	-0.2
Stereotopy head waving bouts, day 7	0.2	0.2	0.7	0.4	0.2	0.2	-0.4	-0.9	-0.4	-0.4	-0.6	-0.5	-0.5	-0.7
Stereotopy head waving duration, day 7	1.5	1.8	2.5	1.4	1.2	1.2	-1.4	-1.6	-1.4	-1.4	0.3	-1.4	-1.4	-1.5
Locomotion velocity, session 8	0.1	0.2	0.7	-0.4	-0.0	0.0	0.4	0.7	0.3	0.3	0.8	-0.0	0.0	0.3
Locomotion distance, session 8	0.3	0.4	0.8	-0.9	-0.8	-0.8	0.8	0.1	0.8	0.8	-0.7	0.5	0.5	-0.0
Degree of sensitization distance	0.1	0.2	0.5	-0.2	-0.4	-0.4	0.2	-0.6	0.2	0.2	-0.7	0.1	0.1	-0.6
Degree of sensitization stereotypy	0.9	1.0	1.7	1.1	0.8	0.8	-1.1	-1.3	-1.0	-1.0	-0.2	-1.1	-1.1	-1.1
Conditioned locomotion	0.6	0.7	0.7	0.8	0.8	0.9	-0.8	-0.8	-0.9	-0.9	0.7	-0.8	-0.8	-0.8
Cocaine response after cond. corrected	0.5	0.6	1.3	-1.2	-0.7	-0.7	1.1	1.0	0.7	0.7	0.2	0.7	0.7	0.6
Cocaine response after cond. not corrected	0.3	0.4	0.8	-0.9	-0.6	-0.6	0.8	0.8	0.6	0.6	-0.0	0.5	0.5	0.5
Cocaine response before conditioning	0.4	0.4	0.8	0.9	0.5	0.5	-0.8	-0.7	-0.7	-0.7	-0.2	-0.7	-0.7	-0.4
Saline control response	2.9	3.9	4.7	2.2	2.1	2.1	-2.0	-1.5	-1.9	-1.9	2.0	-2.1	-2.0	-1.7
Bone: connectivity density	1.9	2.9	4.9	1.6	1.5	1.4	-1.7	-2.2	-1.8	-1.8	0.5	-1.7	-1.7	-2.2
Bone: cortical apparent density	0.3	0.4	0.6	0.4	0.8	0.8	-0.5	0.1	-0.7	-0.7	0.8	-0.8	-0.7	-0.1
Bone: cortical area	0.9	1.4	2.4	1.4	1.0	1.0	-1.3	-1.5	-1.2	-1.2	0.1	-1.2	-1.3	-1.3
Bone: cortical porosity	0.1	0.1	0.4	-0.2	0.1	0.1	0.1	0.6	0.1	0.1	0.1	0.0	0.0	0.6
Bone: cortical porosity	0.1	0.1	0.2	0.0	0.3	0.3	-0.1	0.4	-0.1	-0.1	0.5	-0.2	-0.2	0.3
Bone: cortical thickness	3.2	5.4	7.4	2.5	2.7	2.7	-2.4	-1.2	-2.3	-2.3	2.7	-2.4	-2.4	-1.5
Bone: cortical thickness	0.5	0.6	2.3	0.6	0.9	1.0	-0.6	0.1	-0.7	-0.7	1.5	-0.7	-0.7	-0.2
Bone: cortical tissue density	0.4	0.6	0.9	0.6	0.9	1.0	-0.7	0.0	-0.8	-0.8	0.9	-0.9	-0.9	-0.2
Condit. Reinf. active minus inactive responses	1.1	1.2	1.4	1.0	1.1	1.1	-1.2	-1.1	-1.2	-1.2	0.7	-1.2	-1.2	-1.1
Condit. Reinf. active-inactive response ratio	0.5	0.5	0.7	0.5	0.8	0.8	-0.7	-0.3	-0.8	-0.8	0.8	-0.7	-0.7	-0.5
Condit. Reinf. active responses	0.9	1.2	2.1	1.0	0.9	0.8	-1.1	-1.4	-1.1	-1.1	-0.1	-1.2	-1.2	-1.3
Condit. Reinf. inactive responses	0.2	0.3	1.6	0.1	-0.3	-0.4	-0.0	-0.8	0.1	0.1	-1.3	0.0	-0.0	-0.5
Incentive salience index mean	1.3	1.6	2.3	1.3	1.2	1.1	-1.3	-1.5	-1.3	-1.3	0.5	-1.3	-1.4	-1.5
Condit. Reinf. lever presses	1.0	1.3	2.6	1.3	0.9	0.9	-1.2	-1.6	-1.1	-1.1	0.2	-1.2	-1.2	-1.5
Condit. Reinf. active minus inactive responses	0.1	0.2	1.0	-0.3	-0.5	-0.5	0.4	-0.0	0.3	0.3	-1.0	0.3	0.3	0.4
Condit. Reinf. active-inactive response ratio	0.8	0.9	4.6	-0.7	-1.0	-1.1	0.7	-0.3	0.7	0.7	-2.1	0.6	0.6	0.3
Condit. Reinf. active responses	0.1	0.1	0.2	0.4	0.3	0.3	-0.3	-0.4	-0.3	-0.3	-0.0	-0.3	-0.3	-0.2
Condit. Reinf. inactive responses	0.4	0.5	2.3	0.6	0.7	0.8	-0.5	0.2	-0.6	-0.6	1.5	-0.4	-0.4	-0.1
Condit. Reinf. lever presses	1.0	1.4	2.5	1.4	1.0	0.9	-1.3	-1.6	-1.3	-1.3	0.1	-1.1	-1.1	-1.3
Condit. Reinf. lever reinforcers received	0.2	0.3	0.4	0.6	0.5	0.5	-0.5	-0.6	-0.6	-0.6	0.1	-0.6	-0.6	-0.3
Conditioned reinforcement - actives	0.3	0.5	2.8	-0.7	-0.7	-0.8	0.5	0.1	0.6	0.6	-1.7	0.4	0.4	0.4
Conditioned reinforcement - inactives	0.3	0.5	3.4	-0.4	-0.6	-0.7	0.1	-0.7	0.2	0.2	-1.9	0.1	0.1	-0.4
Conditioned locomotion	2.4	3.1	4.9	-2.1	-2.0	-2.1	1.7	0.9	1.7	1.7	-2.2	1.6	1.6	1.0
Patch foraging indifference point 0 sec	0.4	0.8	1.0	0.9	0.9	0.9	-0.9	-1.0	-0.9	-0.9	0.6	-1.0	-0.9	-1.0
Patch foraging indifference point AUC	1.2	1.8	2.4	1.4	1.4	1.3	-1.4	-1.3	-1.5	-1.5	0.1	-1.5	-1.5	-1.0
Delay disc. indifference point, 0s delay	0.3	0.4	0.6	-0.7	-0.7	-0.7	0.7	0.2	0.7	0.7	-0.4	0.6	0.7	0.0
Delay disc. indifference point, 16s delay	0.1	0.2	0.5	0.3	0.1	0.1	-0.3	-0.7	-0.3	-0.3	-0.3	-0.3	-0.3	-0.6
Delay disc. indifference point, 2s delay	0.3	0.3	1.0	-0.5	-0.7	-0.8	0.5	-0.2	0.5	0.5	-1.0	0.4	0.5	-0.0
Delay disc. indifference point, 24s delay	0.1	0.1	0.5	0.3	0.4	0.4	-0.2	-0.2	-0.3	-0.3	0.7	-0.3	-0.3	-0.4
Delay disc. indifference point, 4s delay	0.3	0.3	0.8	0.4	0.5	0.5	-0.4	-0.5	-0.4	-0.4	0.9	-0.5	-0.4	-0.8
Delay disc. indifference point, 8s delay	0.3	0.4	0.6	-0.7	-0.5	-0.5	0.7	0.8	0.7	0.7	0.2	0.7	0.7	0.5
Indifference point function ln k	2.6	4.6	6.3	-2.5	-2.2	-2.1	2.4	2.2	2.2	2.2	-0.3	2.3	2.3	1.7
Indifference point function log k	2.6	4.6	6.3	-2.5	-2.2	-2.1	2.4	2.2	2.2	2.2	-0.3	2.3	2.3	1.7
Patch foraging total patch changes 0 sec	0.5	0.9	1.2	0.9	1.0	1.0	-0.9	-0.7	-0.9	-0.9	1.1	-1.0	-1.0	-0.8
Patch foraging total patch changes 12 sec	6.1	8.0	10.1	3.0	3.0	3.0	-2.9	-2.5	-3.0	-3.0	1.8	-3.2	-3.1	-2.4
Patch foraging total patch changes 18 sec	0.6	0.8	1.4	0.9	1.0	0.9	-0.9	-0.8	-1.0	-1.0	0.4	-1.2	-1.0	-0.6
Patch foraging total patch changes 24 sec	5.0	8.5	10.0	3.0	2.9	2.9	-3.0	-2.9	-3.2	-3.2	1.9	-2.9	-3.0	-2.9
Patch foraging total patch changes 6 sec	1.3	2.0	2.3	1.4	1.4	1.4	-1.4	-1.5	-1.5	-1.5	1.1	-1.5	-1.4	-1.4
Patch foraging time to switch 0 sec	0.3	0.6	1.8	0.6	0.3	0.3	-0.6	-1.3	-0.5	-0.5	-0.8	-0.8	-0.8	-1.1
Patch foraging water rate 0 sec	0.3	0.7	1.3	-0.9	-0.7	-0.6	0.7	1.2	0.7	0.7	0.2	1.0	0.9	1.1
Patch foraging water rate 12 sec	1.4	3.0	4.7	-1.7	-1.5	-1.4	1.7	2.2	1.7	1.7	0.3	2.1	2.0	1.8
Patch foraging water rate 18 sec	0.4	0.7	1.5	-0.7	-0.7	-0.6	0.7	0.9	0.8	0.8	0.8	1.2	1.0	0.5
Patch foraging water rate 24 sec	1.3	1.8	2.6	-1.5	-1.2	-1.2	1.4	1.6	1.4	1.4	-0.0	1.5	1.3	1.4
Patch foraging water rate 6 sec	1.4	2.1	3.4	-1.4	-1.2	-1.1	1.4	1.8	1.5	1.5	0.5	1.7	1.6	1.5
Seeking ratio, delayed vs. immediate footshock	0.0	0.1	0.2	0.3	0.2	0.1	-0.4	-0.3	-0.2	-0.2	0.1	-0.2	-0.2	-0.3
Distance traveled before self-admin	2.2	2.8	4.3	1.8	1.5	1.4	-1.8	-2.1	-1.8	-1.8	0.2	-1.7	-1.8	-1.8
Distance traveled after self-admin	0.4	0.5	0.8	0.7	0.9	0.9	-0.9	-0.5	-0.9	-0.9	0.5	-0.6	-0.7	-0.4
Extensor digitorum longus weight	6.4	25.2	28.9	5.4	5.1	5.1	-5.4	-4.9	-5.2	-5.2	3.5	-5.0	-5.0	-5.2
Bone: elastic displacement	0.4	0.5	1.6	-0.7	-0.4	-0.3	0.6	1.2	0.6	0.6	0.6	0.7	0.7	1.0
Bone: elastic work	1.0	1.3	3.3	1.0	1.3	1.3	-1.1	-0.5	-1.1	-1.1	1.8	-1.1	-1.1	-0.8
Bone: endosteal estimation	1.1	2.5	7.4	-1.3	-2.0	-2.1	1.4	-0.5	1.3	1.3	-2.7	1.5	1.4	0.0
Bone: endosteal perimeter	1.9	3.9	12.8	-1.7	-2.4	-2.5	1.7	-0.3	1.7	1.7	-3.6	1.8	1.8	0.4
Epididymis fat weight	0.7	2.5	8.2	-1.1	-2.0	-2.0	1.3	-0.2	1.3	1.3	-2.9	1.5	1.6	0.4
Delta time in closed arm before/after self-admin	1.1	1.1	3.7	0.8	1.1	1.2	-0.8	-0.4	-0.8	-0.8	1.9	-0.9	-1.0	-1.0
Delta time in open arm before/after self-admin	2.0	2.0	2.9	1.4	1.3	1.2	-1.5	-1.7	-1.5	-1.5	-0.2	-1.7	-1.7	-1.4
Diff in mean of infusions in LGA sessions	2.4	2.9	3.9	1.6	1.9	2.0	-1.7	-1.1	-1.7	-1.7	1.7	-1.8	-1.9	-1.3
Delay discount exponential model param	0.0	0.1	0.2	-0.1	-0.1	-0.1	0.1	0.4	0.1	0.1	-0.2	0.2	0.1	0.5
Extinction: sum of active levers before priming	3.8	4.2	4.8	2.1	2.1	2.0	-2.2	-2.1	-2.2	-2.2	1.1	-2.0	-2.2	-2.1
Active lever presses in extinction session 6	3.0	2.9	4.0	1.7	1.7	1.7	-1.8	-1.8	-1.8	-1.8	0.5	-2.0	-2.0	-1.6
Bone: final force	1.7	2.7	4.3	1.7	1.4	1.4	-1.7	-2.1	-1.6	-1.6	0.4	-1.7	-1.8	-2.0
Bone: final moment	1.7	2.8	4.4	1.8	1.5	1.4	-1.7	-2.1	-1.7	-1.7	0.5	-1.7	-1.8	-2.0
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.0	-0.3	-0.3	0.0	-0.0	0.2	0.2	-0.4	0.5	0.5	0.4
Glucose	2.3	3.6	5.0	-1.9	-2.2	-2.2	2.0	0.9	1.9	1.9	-1.8	2.2	2.2	1.2
Heart weight	0.2	0.3	0.6	-0.5	-0.7	-0.7	0.6	-0.1	0.5	0.5	-0.2	0.8	0.8	-0.3
Delay discount hyperbolic model param	0.0	0.0	0.2	-0.0	0.0	0.0	0.0	0.4	0.0	0.0	-0.0	0.1	0.0	0.4
Intermittent access intake day 1-15 change	1.1	2.3	4.2	-1.4	-1.6	-1.7	1.5	1.2	1.4	1.4	-2.0	1.4	1.4	1.5
Intermittent access intake escalation	1.4	2.8	4.9	-1.6	-1.8	-1.8	1.6	1.3	1.6	1.6	-2.2	1.6	1.5	1.7
Intermittent access intake escalation 2	0.7	0.8	3.0	-0.7	-1.0	-1.0	0.8	0.4	0.8	0.8	-1.7	0.7	0.7	0.8
Intermitt. access day 1 inactive lever presses	0.4	1.6	1.9	-1.3	-1.3	-1.3	1.3	1.1	1.4	1.4	-1.4	1.0	1.1	1.3
Intermitt. access day 15 inactive lever presses	0.5	1.0	3.2	0.8	0.3	0.2	-0.9	-1.8	-0.8	-0.8	-1.3	-0.9	-0.9	-1.4
Intermitt. access escalation Index	0.6	0.8	1.2	-0.9	-0.8	-0.8	1.0	1.1	0.9	0.9	-0.1	1.0	1.0	1.0
Intermittent access day 1 total infusions	0.8	1.3	5.5	-0.9	-1.4	-1.5	0.7	-1.0	0.8	0.8	-2.3	0.7	0.5	-0.8
Intermittent access day 15 total infusions	3.6	5.4	13.3	-2.3	-2.8	-2.9	2.1	0.7	2.2	2.2	-3.7	2.2	2.0	1.2
Intermittent access terminal intake (last 3 days)	1.8	2.4	11.3	-1.3	-1.9	-2.0	1.1	-0.6	1.1	1.1	-3.4	1.1	0.9	-0.1
Intermittent access total infusions	1.8	2.2	8.4	-1.4	-1.8	-1.9	1.1	-0.4	1.2	1.2	-2.9	1.1	1.0	-0.1
Intermittent access day 1 locomotion	0.4	0.5	2.2	-0.5	-0.8	-0.8	0.4	-0.9	0.3	0.3	-1.5	0.1	0.1	-0.9
Intermittent access day 15 total locomotion	0.5	1.0	6.1	-0.7	-1.0	-1.1	0.4	-0.8	0.4	0.4	-2.5	0.3	0.2	-0.6
Intermittent access total locomotion	1.5	1.8	10.6	-0.8	-1.4	-1.5	0.5	-1.5	0.5	0.5	-3.2	0.3	0.2	-1.1
Intermittent access standard deviation	0.6	1.3	2.6	-1.2	-1.3	-1.3	1.1	0.7	1.1	1.1	-1.6	1.1	1.0	0.9
Left kidney weight	0.2	0.7	3.0	-0.6	-1.0	-1.1	0.6	-0.5	0.6	0.6	-1.7	0.7	0.7	-0.2
Right kidney weight	0.1	0.4	1.8	-0.3	-0.7	-0.8	0.4	-0.4	0.4	0.4	-1.3	0.5	0.6	-0.2
Cocaine induced anxiety	0.0	0.0	0.2	0.1	0.2	0.2	-0.2	-0.1	-0.1	-0.1	-0.3	-0.4	-0.2	-0.0
Post-drug Anxiety	0.3	0.3	0.6	0.6	0.6	0.6	-0.7	-0.5	-0.6	-0.6	0.2	-0.8	-0.5	-0.5
Baseline Anxiety	0.4	0.5	1.4	0.6	0.7	0.8	-0.7	-0.4	-0.6	-0.6	1.2	-0.5	-0.5	-0.6
Tail length	0.3	1.4	3.6	1.4	1.4	1.4	-1.1	-0.3	-1.0	-1.0	1.9	-1.0	-0.9	-0.5
Length with tail	1.4	6.0	8.2	2.9	2.7	2.7	-2.6	-1.9	-2.5	-2.5	2.4	-2.3	-2.4	-2.0
Length without tail	2.9	9.5	10.9	3.3	3.3	3.3	-3.3	-2.6	-3.2	-3.2	2.8	-2.9	-3.0	-2.8
Times rat made contact with spout	0.2	0.2	1.3	0.4	0.5	0.6	-0.4	0.2	-0.3	-0.3	1.2	-0.1	-0.1	0.1
Lifetime Intake	1.3	1.6	4.9	-1.3	-1.6	-1.6	1.0	-0.3	1.1	1.1	-2.2	1.0	0.9	-0.1
Liver weight, left	1.1	1.8	2.3	-1.3	-1.3	-1.3	1.4	1.4	1.3	1.3	-0.6	1.5	1.5	1.5
Liver weight, right	1.3	2.2	2.9	-1.5	-1.6	-1.6	1.6	1.2	1.6	1.6	-0.6	1.7	1.7	1.2
Locomotor activity	0.8	1.3	2.6	-1.1	-0.8	-0.7	1.1	1.6	1.1	1.1	0.8	1.3	1.3	1.3
Locomotor testing distance	0.8	1.4	2.6	-1.3	-0.9	-0.8	1.2	1.6	1.2	1.2	0.8	1.3	1.3	1.2
Locomotor testing rearing	0.7	1.5	2.3	-1.2	-1.1	-1.0	1.3	1.5	1.3	1.3	0.3	1.4	1.4	1.3
Locomotion in novel chamber	2.0	2.6	4.3	-1.7	-1.9	-1.9	1.5	0.8	1.6	1.6	-2.1	1.5	1.7	1.1
Locomotion in novel chamber post-restriction	1.9	3.0	3.5	-1.9	-1.9	-1.9	1.7	1.3	1.7	1.7	-1.9	1.7	1.8	1.6
Fecal boli incidents, locomotor time 1	0.3	0.4	2.0	-0.4	-0.7	-0.7	0.4	-0.0	0.4	0.4	-1.4	0.4	0.4	0.4
Change in fecal boli incidents, locomotor task	1.1	1.1	1.5	-1.2	-1.0	-1.0	1.1	1.2	1.2	1.2	0.0	1.1	1.2	0.9
Time >=10cm from walls, locomotor time 1	2.3	2.5	7.5	-1.4	-1.8	-1.9	1.3	0.3	1.5	1.5	-2.7	1.4	1.3	0.8
Bouts of movement, locomotor time 1	0.3	0.3	0.6	0.3	0.8	0.8	-0.5	0.6	-0.2	-0.2	0.8	-0.6	-0.5	0.6
Total resting periods, locomotor time 1	0.2	0.2	0.4	0.3	0.6	0.7	-0.5	0.4	-0.3	-0.3	0.5	-0.6	-0.5	0.4
Rest time, locomotor task time 1	1.5	1.9	2.6	-1.3	-1.4	-1.4	1.5	1.4	1.2	1.2	-1.1	1.5	1.5	1.6
Distance moved, locomotor task time 1	0.2	0.4	0.7	0.6	0.5	0.5	-0.6	-0.8	-0.6	-0.6	0.3	-0.6	-0.6	-0.9
Vertical activity count, locomotor time 1	0.2	0.5	0.7	-0.8	-0.7	-0.7	0.7	0.6	0.8	0.8	-0.5	0.7	0.7	0.5
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.9	-0.1	-0.3	-0.3	0.1	-0.0	0.1	0.1	-1.0	0.1	0.1	0.3
Bouts of movement, locomotor time 2	0.9	1.4	1.7	1.3	1.3	1.3	-1.3	-0.9	-1.3	-1.3	1.0	-1.2	-1.2	-0.9
Total resting periods, locomotor time 2	0.4	0.6	0.8	0.9	0.9	0.9	-0.9	-0.6	-0.9	-0.9	0.6	-0.8	-0.8	-0.6
Rest time, locomotor task time 2	3.0	3.8	4.4	-2.0	-2.1	-2.0	2.0	1.7	2.0	2.0	-1.5	2.1	2.1	1.8
Distance moved, locomotor task time 2	0.6	0.7	1.0	0.8	1.0	1.0	-0.8	-0.3	-0.9	-0.9	0.9	-0.9	-0.8	-0.4
Vertical activity count, locomotor time 2	0.2	0.2	1.2	-0.1	0.3	0.3	0.1	0.9	0.1	0.1	1.1	0.0	0.0	0.6
Light reinforcement 1	0.0	0.1	0.2	-0.1	-0.1	-0.1	0.1	0.4	0.1	0.1	0.1	0.2	0.3	0.5
Light reinforcement 2	0.4	0.5	4.1	-0.1	-0.7	-0.8	0.2	-0.6	0.3	0.3	-2.0	0.2	0.4	-0.1
Bone: marrow area	1.3	2.9	7.7	-1.5	-2.1	-2.2	1.6	-0.3	1.5	1.5	-2.8	1.7	1.6	0.2
Bone: maximum diameter	0.3	0.5	1.7	0.5	0.0	-0.0	-0.4	-1.3	-0.5	-0.5	-1.2	-0.5	-0.5	-0.9
Bone: maximum force	2.6	4.6	9.7	2.3	1.7	1.6	-2.2	-3.1	-2.2	-2.2	-0.0	-2.1	-2.2	-2.8
Bone: maximum moment	2.7	4.6	9.4	2.3	1.7	1.6	-2.2	-3.1	-2.2	-2.2	0.1	-2.1	-2.2	-2.8
Mean time between licks in bursts	0.3	0.6	3.4	0.6	0.8	0.9	-0.7	0.0	-0.6	-0.6	1.8	-0.4	-0.4	-0.5
Mean num. licks in bursts	0.1	0.1	0.4	-0.3	-0.0	0.0	0.3	0.6	0.1	0.1	0.5	0.1	0.1	0.5
Cd content in liver	0.9	1.0	2.1	-1.1	-1.1	-1.1	1.1	0.5	0.9	0.9	-1.5	0.8	0.8	0.7
Co content in liver	1.1	1.2	3.9	-1.1	-0.6	-0.5	1.0	2.0	1.0	1.0	0.8	0.9	0.9	1.6
Cu content in liver	0.0	0.0	0.2	-0.2	0.0	0.0	0.1	0.4	0.1	0.1	0.3	0.1	0.1	0.3
Fe content in liver	0.0	0.0	0.1	-0.3	-0.2	-0.2	0.3	0.1	0.1	0.1	-0.1	0.1	0.1	0.0
K content in liver	0.4	0.4	0.7	0.9	0.6	0.5	-0.7	-0.8	-0.5	-0.5	0.4	-0.6	-0.6	-0.9
Mg content in liver	0.0	0.0	0.2	0.1	0.0	0.0	-0.1	-0.3	-0.0	-0.0	0.3	-0.0	-0.0	-0.5
Mn content in liver	3.2	3.6	4.5	2.1	1.9	1.8	-2.1	-2.1	-2.0	-2.0	0.8	-1.9	-1.9	-1.9
Na content in liver	0.4	0.5	0.7	0.8	0.6	0.6	-0.7	-0.8	-0.7	-0.7	0.2	-0.7	-0.7	-0.8
Rb content in liver	2.6	3.1	3.9	-1.7	-1.7	-1.7	1.9	1.9	2.0	2.0	-0.6	1.9	1.9	1.7
Se content in liver	0.2	0.2	0.7	0.4	0.0	-0.0	-0.3	-0.8	-0.3	-0.3	-0.8	-0.3	-0.3	-0.5
Sr content in liver	4.3	3.7	4.2	2.0	2.0	2.0	-2.0	-1.7	-2.0	-2.0	1.3	-2.0	-2.0	-1.7
Zn content in liver	2.7	3.0	3.6	1.6	1.8	1.8	-1.7	-1.6	-1.8	-1.8	1.2	-1.9	-1.9	-1.8
Bone: minimum diameter	0.8	1.4	5.6	-0.8	-1.4	-1.5	0.8	-0.8	0.9	0.9	-2.4	1.0	1.0	-0.3
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.2	0.2	0.2	-0.3	-0.5	-0.4	-0.4	0.1	-0.2	-0.1	-0.4
Time in novel zone, hab. session 1	1.4	1.4	2.1	-1.2	-1.1	-1.0	1.2	1.4	1.3	1.3	-0.2	1.2	1.2	1.3
Total zone transitions, hab. session 1	0.2	0.3	0.4	0.5	0.6	0.6	-0.5	-0.3	-0.4	-0.4	0.6	-0.6	-0.6	-0.4
Total locomotion distance, hab. session 1	0.1	0.2	0.8	-0.4	-0.4	-0.5	0.3	-0.3	0.3	0.3	-0.9	0.1	0.0	-0.2
Locomotion velocity, hab. session 1	0.1	0.2	0.4	0.3	0.2	0.2	-0.3	-0.6	-0.2	-0.2	-0.4	-0.5	-0.5	-0.6
Time in familiar zone, hab. session 2	0.4	0.4	1.1	-0.3	-0.2	-0.2	0.3	1.1	0.3	0.3	0.8	0.8	0.8	1.0
Time in novel zone, hab. session 2	0.5	0.5	1.3	0.6	0.5	0.5	-0.6	-1.1	-0.6	-0.6	-0.1	-0.8	-0.9	-1.1
Total zone transitions, hab. session 2	1.3	1.7	2.3	1.2	1.3	1.3	-1.3	-1.3	-1.2	-1.2	1.1	-1.4	-1.4	-1.5
Total locomotion distance, hab. session 2	0.1	0.2	0.5	0.3	0.2	0.2	-0.3	-0.7	-0.2	-0.2	0.1	-0.5	-0.5	-0.7
Locomotion velocity, hab. session 2	0.1	0.1	0.4	0.1	0.0	-0.0	-0.1	-0.6	-0.0	-0.0	-0.3	-0.3	-0.4	-0.7
Novel to familiar place preference ratio	2.0	2.1	3.1	1.6	1.4	1.4	-1.5	-1.8	-1.4	-1.4	0.3	-1.5	-1.6	-1.6
Novelty place preference	1.2	1.3	2.1	1.3	1.0	1.0	-1.2	-1.4	-1.1	-1.1	0.1	-1.1	-1.2	-1.3
Time in novel zone, NPP test	1.3	1.4	2.1	1.3	1.1	1.1	-1.2	-1.5	-1.1	-1.1	0.2	-1.2	-1.2	-1.3
Total zone transitions, NPP test	1.0	1.5	2.1	1.1	1.3	1.3	-1.1	-1.0	-1.1	-1.1	1.1	-1.4	-1.5	-1.3
Total locomotion distance, NPP test	0.1	0.1	0.3	-0.0	0.2	0.2	-0.0	-0.2	0.0	0.0	0.3	-0.5	-0.5	-0.4
Locomotion velocity, NPP test	0.0	0.0	0.2	-0.1	0.1	0.1	0.1	-0.0	0.1	0.1	0.2	-0.4	-0.4	-0.2
Intraocular pressure	0.1	0.1	0.5	-0.3	-0.3	-0.2	0.3	0.6	0.3	0.3	-0.2	0.4	0.4	0.7
Delta distance traveled before/after self-admin	0.6	0.6	1.7	-0.8	-0.3	-0.3	0.6	1.3	0.6	0.6	0.8	0.9	0.9	1.0
Delta ambulatory time before/after self-admin	0.8	1.0	2.4	-1.0	-0.6	-0.5	0.9	1.5	0.9	0.9	0.7	1.1	1.1	1.3
Parametrial fat weight	1.7	3.9	10.5	-1.7	-2.4	-2.5	1.9	0.2	1.7	1.7	-3.2	1.9	1.9	0.8
Pavlov. Cond. lever latency	1.0	1.2	2.1	-1.2	-0.9	-0.9	1.1	1.4	1.1	1.1	-0.2	1.1	1.1	1.4
Pavlov. Cond. magazine entry latency	1.1	1.5	3.1	1.3	0.9	0.8	-1.3	-1.8	-1.3	-1.3	-0.4	-1.2	-1.2	-1.5
Pavlov. Cond. change in total contacts	0.5	0.6	1.6	0.7	0.3	0.3	-0.7	-1.2	-0.7	-0.7	-0.9	-0.7	-0.7	-0.8
Pavlov. Cond. index score	0.8	1.0	1.6	1.1	0.8	0.8	-1.1	-1.3	-1.1	-1.1	-0.1	-1.0	-1.0	-1.1
Pavlov. Cond. latency score	0.6	0.8	1.4	1.0	0.7	0.7	-1.0	-1.2	-1.0	-1.0	-0.0	-0.9	-0.9	-1.1
Pavlov. Cond. lever contacts	0.5	0.6	1.3	0.8	0.6	0.5	-0.8	-1.1	-0.8	-0.8	0.0	-0.7	-0.8	-1.1
Pavlov. Cond. magazine entry number	0.9	1.1	1.4	-1.1	-0.9	-0.9	1.2	1.2	1.2	1.2	-0.0	1.1	1.1	0.9
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.2	0.1	0.2	0.2	-0.2	0.0	-0.1	-0.1	-0.2	-0.4	-0.4	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.9	1.1	0.8	0.8	-1.1	-1.4	-1.1	-1.1	-0.2	-1.0	-1.0	-1.1
Pavlov. Cond. response bias	1.0	1.3	2.0	1.3	0.9	0.9	-1.2	-1.4	-1.2	-1.2	-0.1	-1.2	-1.2	-1.2
Pavlov. Cond. lever latency	0.6	0.8	1.6	-1.0	-0.7	-0.7	1.0	1.3	1.1	1.1	-0.1	0.8	0.8	1.0
Pavlov. Cond. magazine entry latency	5.4	6.5	7.8	2.7	2.6	2.6	-2.7	-2.4	-2.7	-2.7	1.4	-2.8	-2.8	-2.3
Pavlov. Cond. change in total contacts	1.4	2.3	3.9	1.6	1.3	1.2	-1.6	-2.0	-1.8	-1.8	-0.1	-1.5	-1.5	-1.5
Pavlov. Cond. index score	2.9	3.9	5.4	2.1	1.8	1.7	-2.1	-2.3	-2.2	-2.2	0.5	-2.0	-2.1	-2.0
Pavlov. Cond. latency score	2.7	3.5	5.3	2.0	1.7	1.6	-2.0	-2.3	-2.1	-2.1	0.3	-2.0	-2.0	-1.9
Pavlov. Cond. lever contacts	0.5	0.7	1.2	0.9	0.7	0.7	-0.9	-1.1	-1.0	-1.0	0.1	-0.7	-0.8	-0.8
Pavlov. Cond. magazine entry number	8.0	9.9	11.8	-3.3	-3.2	-3.1	3.3	3.1	3.4	3.4	-1.6	3.4	3.4	2.9
Pavlov. Cond. intertrial magazine entries	1.5	2.3	2.8	-1.6	-1.5	-1.5	1.7	1.5	1.5	1.5	-1.2	1.5	1.5	1.6
Pavlov. Cond. lever-magazine prob. diff.	3.3	4.5	5.7	2.2	2.0	1.9	-2.3	-2.4	-2.4	-2.4	0.6	-2.2	-2.2	-2.1
Pavlov. Cond. response bias	2.2	3.0	3.9	1.9	1.6	1.6	-1.9	-1.9	-2.0	-2.0	0.7	-1.7	-1.7	-1.7
Time in closed arm before self-admin	0.2	0.2	1.4	0.0	-0.5	-0.5	0.1	-0.4	0.1	0.1	-1.2	0.3	0.3	-0.1
Time in closed arm after self-admin	0.9	0.9	1.5	-0.8	-1.0	-1.0	1.0	0.9	1.0	1.0	-0.4	1.1	1.2	0.8
Time in open arm before self-admin	1.2	1.3	3.1	-1.2	-0.6	-0.5	1.1	1.8	1.1	1.1	1.3	1.1	1.1	1.1
Time in open arm after self-admin	0.5	0.6	1.3	0.4	0.9	1.0	-0.7	-0.2	-0.7	-0.7	1.2	-0.9	-0.9	-0.5
Bone: periosteal estimation	0.3	0.6	3.2	0.1	-0.5	-0.6	-0.0	-1.4	-0.0	-0.0	-1.8	0.1	0.0	-0.9
Bone: periosteal perimeter	0.2	0.4	2.2	0.1	-0.4	-0.5	-0.1	-1.1	-0.1	-0.1	-1.5	0.0	-0.0	-0.6
Bone: post-yield work	0.8	1.1	6.3	-0.2	-0.9	-1.0	0.2	-1.8	-0.0	-0.0	-2.5	0.2	0.2	-1.1
Progressive ratio test 1 active lever presses	0.5	0.6	1.6	-1.0	-0.9	-0.9	0.7	0.2	0.8	0.8	-1.3	0.6	0.5	0.2
Progressive ratio test 1 breakpoint	0.5	0.6	1.7	-1.0	-0.9	-0.9	0.7	0.2	0.8	0.8	-1.3	0.6	0.5	0.2
Progressive ratio test 1 inactive lever presses	0.4	0.6	1.3	0.7	0.6	0.6	-0.8	-1.1	-0.7	-0.7	-0.1	-0.9	-0.9	-1.1
Progressive ratio test 2 active lever presses	1.3	1.5	6.0	-1.3	-1.5	-1.5	1.0	-0.0	1.0	1.0	-2.4	0.9	0.8	0.2
Progressive ratio test 2 breakpoint	1.2	1.4	5.9	-1.2	-1.4	-1.5	0.9	-0.1	0.9	0.9	-2.4	0.8	0.7	0.2
Progressive ratio test 2 inactive lever presses	0.8	1.2	6.2	-0.9	-1.3	-1.4	0.8	-0.4	0.8	0.8	-2.5	0.7	0.6	-0.0
Incentive Sensitization - Responses	0.6	0.9	2.5	0.7	0.4	0.3	-0.8	-1.6	-0.9	-0.9	-1.0	-0.8	-0.8	-1.4
Incentive Sensitization - Breakpoint	0.6	0.7	2.3	0.6	0.2	0.1	-0.7	-1.5	-0.8	-0.8	-1.1	-0.7	-0.7	-1.2
Sum of active levers in priming session hrs 5-6	1.0	0.9	1.4	1.0	1.0	0.9	-1.1	-0.8	-1.1	-1.1	-0.3	-1.1	-1.2	-0.4
Progressive ratio	0.2	0.2	1.2	0.1	-0.4	-0.4	-0.2	-0.9	-0.0	-0.0	-1.1	0.1	0.1	-0.6
Food seeking constrained by brief footshock	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.1	0.2	0.3	0.3	0.1	0.3	0.2	0.1
Seeking ratio, punishment vs. effort	0.2	0.2	1.4	-0.2	0.2	0.2	0.3	0.8	0.2	0.2	1.2	0.1	0.1	0.4
Retroperitoneal fat weight	3.7	15.6	20.1	-3.9	-4.5	-4.5	4.2	2.7	4.2	4.2	-3.7	4.1	4.2	2.9
Reaction time number correct	0.4	0.7	1.8	1.0	0.9	1.0	-1.0	-0.5	-0.9	-0.9	1.3	-0.5	-0.6	-0.5
Reaction time mean minus median	0.2	0.5	0.9	0.8	0.7	0.6	-0.8	-0.7	-0.9	-0.9	-0.5	-0.8	-0.7	-0.3
Reaction time mean minus median AUC	0.1	0.2	0.3	0.4	0.5	0.5	-0.5	0.1	-0.5	-0.5	0.0	-0.3	-0.3	0.3
Reaction time num false alarms	0.4	0.6	1.9	-0.9	-0.2	-0.1	0.8	1.4	0.5	0.5	1.3	0.4	0.4	0.9
Reaction time num false alarms AUC	0.3	0.5	3.3	-0.3	0.4	0.5	0.3	1.1	-0.1	-0.1	1.8	-0.0	-0.1	0.5
Reaction time trials correct on left	0.4	0.7	1.8	1.0	0.9	1.0	-1.0	-0.5	-0.9	-0.9	1.3	-0.5	-0.6	-0.5
Reaction time trials on left	0.4	0.8	1.9	1.0	1.0	1.0	-1.0	-0.4	-0.9	-0.9	1.4	-0.5	-0.6	-0.5
Reaction time mean	0.1	0.1	0.6	-0.2	-0.1	-0.2	0.1	0.1	-0.1	-0.1	-0.8	-0.1	-0.0	0.4
Reaction time mean AUC	0.1	0.1	0.9	-0.3	-0.3	-0.4	0.2	0.2	0.1	0.1	-0.9	0.1	0.2	0.5
Median of all reaction times	0.0	0.1	0.4	-0.2	-0.2	-0.2	0.1	0.0	-0.1	-0.1	-0.7	-0.1	-0.1	0.2
Reaction time omissions	0.3	0.4	0.7	0.6	0.8	0.8	-0.6	-0.0	-0.8	-0.8	0.6	-0.8	-0.7	-0.1
Reaction time false alarm rate	0.3	0.4	1.3	-0.9	-0.3	-0.2	0.8	1.1	0.5	0.5	0.7	0.3	0.3	0.7
Reaction time premature initiation rate	4.3	5.9	6.8	2.6	2.5	2.5	-2.4	-2.1	-2.5	-2.5	2.5	-2.3	-2.2	-2.5
Reaction time premature initiations	4.4	7.8	10.8	3.0	3.0	3.0	-2.8	-2.0	-2.9	-2.9	3.3	-2.5	-2.5	-2.5
Std. dev. reaction times	0.1	0.1	0.5	-0.3	-0.1	-0.1	0.1	0.4	-0.1	-0.1	-0.6	0.0	0.1	0.7
Reaction time trials completed	0.4	0.8	1.9	1.0	1.0	1.0	-1.0	-0.4	-0.9	-0.9	1.4	-0.5	-0.6	-0.5
Reaction time trials AUC	0.3	0.6	1.7	0.9	0.9	0.9	-0.9	-0.4	-0.8	-0.8	1.3	-0.4	-0.5	-0.5
Run reversals in cocaine runway, females	0.5	0.5	1.2	0.5	0.5	0.5	-0.5	-0.8	-0.5	-0.5	0.9	-0.6	-0.6	-1.1
Run reversals in cocaine runway, males	0.5	0.5	0.9	-0.7	-0.6	-0.6	0.7	0.9	0.8	0.8	-0.1	0.7	0.7	0.9
Latency to leave start box in cocaine runway	0.4	0.5	1.2	-0.6	-0.9	-1.0	0.7	-0.0	0.6	0.6	-1.1	0.7	0.7	0.1
Latency to leave start box in cocaine runway, F	0.0	0.0	0.2	0.2	0.0	0.0	-0.1	-0.4	-0.2	-0.2	-0.1	-0.2	-0.2	-0.4
Latency to leave start box in cocaine runway, M	2.3	2.1	2.8	-1.5	-1.7	-1.7	1.5	0.9	1.5	1.5	-1.5	1.5	1.5	1.0
Std. dev. time between licks in bursts	0.2	0.2	1.0	-0.2	-0.1	-0.0	0.2	0.8	0.3	0.3	1.0	0.5	0.5	0.4
Total sessions with >9 infusions	0.8	1.0	1.5	-1.2	-1.2	-1.2	1.0	0.5	1.0	1.0	-1.2	1.0	0.9	0.5
Short access day 1 total inactive lever presses	0.1	0.1	0.3	-0.5	-0.4	-0.4	0.2	-0.4	0.1	0.1	-0.6	0.1	0.2	-0.4
Short access day 10 total inactive lever presses	0.3	0.6	0.9	-0.9	-0.7	-0.7	0.9	1.0	0.8	0.8	-0.2	0.7	0.8	0.9
Short access day 1 total infusions	1.3	1.7	2.5	-1.5	-1.6	-1.6	1.3	0.6	1.3	1.3	-1.4	1.3	1.2	0.7
Short access day 10 total infusions	0.6	0.7	2.9	-0.7	-1.1	-1.1	0.6	-0.6	0.6	0.6	-1.7	0.5	0.5	-0.6
Short access total infusions	0.7	0.9	1.6	-1.1	-1.2	-1.3	0.9	0.0	1.0	1.0	-1.2	0.9	0.8	-0.0
Short access day 1 locomotion	0.4	0.4	1.4	-0.8	-0.8	-0.9	0.6	-0.1	0.6	0.6	-1.2	0.5	0.5	-0.0
Short access day 10 total locomotion	0.2	0.4	1.7	-0.1	-0.3	-0.4	-0.0	-1.1	-0.1	-0.1	-1.3	-0.2	-0.2	-1.0
Short access total locomotion	0.4	0.4	2.2	-0.6	-0.7	-0.8	0.4	-0.6	0.4	0.4	-1.5	0.2	0.2	-0.5
One hour access (0.3 mA shock)	1.4	1.7	5.4	-1.3	-1.6	-1.7	1.2	-0.0	1.1	1.1	-2.3	0.9	1.0	0.2
Compulsive drug intake	1.2	1.4	5.7	1.1	1.4	1.5	-0.9	-0.0	-1.1	-1.1	2.4	-0.7	-0.8	-0.2
One hour access (shock baseline)	3.2	5.0	13.2	-2.3	-2.6	-2.7	2.1	0.7	2.2	2.2	-3.6	1.8	1.8	1.0
Social response proportion	0.0	0.0	0.2	0.5	0.2	0.2	-0.3	-0.1	-0.1	-0.1	0.4	-0.1	-0.0	-0.1
Social responses	0.1	0.2	0.9	0.4	0.4	0.5	-0.3	0.3	-0.2	-0.2	1.0	-0.1	-0.1	0.3
Social time	0.1	0.2	0.7	0.0	0.2	0.2	0.1	0.7	0.1	0.1	0.8	0.2	0.2	0.6
Soleus weight	2.9	8.5	10.0	-3.1	-3.0	-3.0	3.1	2.7	3.2	3.2	-1.8	3.0	3.0	2.8
Bone: stiffness	0.7	1.2	2.7	1.2	0.7	0.7	-1.1	-1.6	-1.0	-1.0	-0.5	-1.0	-1.1	-1.3
Tibialis anterior weight	9.0	30.6	34.4	5.9	5.8	5.8	-5.9	-5.0	-5.8	-5.8	3.8	-5.8	-5.8	-5.2
Time to tail flick, vehicle, before self-admin	0.3	0.3	1.0	0.3	0.0	-0.0	-0.4	-1.0	-0.4	-0.4	-0.7	-0.4	-0.4	-0.9
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.8	0.5	0.4	0.4	-0.5	-0.8	-0.5	-0.5	0.3	-0.5	-0.5	-0.9
Time to tail flick, test, before self-admin	0.3	0.3	1.5	0.3	0.2	0.2	-0.5	-1.0	-0.5	-0.5	0.1	-0.3	-0.3	-1.2
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.3	0.1	0.1	-0.3	-0.3	-0.2	-0.2	-0.4	-0.2	-0.1	-0.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.7	0.5	0.5	0.6	-0.4	-0.2	-0.3	-0.3	0.8	-0.4	-0.5	-0.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.6	0.2	0.2	0.2	-0.1	0.5	-0.1	-0.1	-0.1	-0.2	-0.2	0.8
Tibia length	1.4	3.9	6.5	2.1	1.7	1.6	-2.1	-2.5	-2.0	-2.0	-0.4	-2.3	-2.2	-2.1
Ambulatory time before self-admin	1.6	2.4	3.8	1.6	1.3	1.3	-1.7	-1.9	-1.6	-1.6	-0.1	-1.6	-1.7	-1.6
Ambulatory time after self-admin	0.2	0.2	0.4	0.4	0.4	0.3	-0.6	-0.6	-0.5	-0.5	-0.2	-0.3	-0.3	-0.4
Bone: tissue strength	0.3	0.3	0.6	-0.3	-0.5	-0.5	0.5	0.6	0.6	0.6	0.0	0.8	0.7	0.6
Total heroin consumption	5.9	6.9	9.0	2.7	3.0	3.0	-2.7	-1.8	-2.7	-2.7	2.3	-2.8	-2.9	-1.9
Bone: trabecular number	1.1	1.8	4.0	1.3	1.0	1.0	-1.3	-2.0	-1.4	-1.4	0.1	-1.3	-1.2	-1.9
Bone: trabecular spacing	0.7	0.9	2.5	-0.7	-0.5	-0.5	0.8	1.6	0.9	0.9	0.6	0.8	0.8	1.4
Bone: trabecular thickness	0.2	0.2	1.0	-0.4	-0.5	-0.5	0.3	-0.1	0.3	0.3	-1.0	0.4	0.4	0.2
Bone: trabecular tissue density	5.1	7.6	10.2	-3.0	-2.6	-2.6	3.0	3.2	2.9	2.9	-1.5	2.6	2.6	3.1
Water consumed over 24 hours	0.6	0.8	1.7	1.1	1.0	1.0	-1.0	-0.4	-0.9	-0.9	1.3	-0.6	-0.6	-0.5
Number of responses in last shaping day	0.2	0.2	0.8	0.3	0.5	0.5	-0.3	-0.1	-0.3	-0.3	0.9	-0.4	-0.4	-0.3