Stx5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Stx5 0.11 0.06 1.4e-14 0.13 0.13 0.13 0.13 6.4e-15 7.1e-15 6.0e-15 2.6e-15
2 Adipose alternative TSS XM_006230997.3 0.04 0.03 9.6e-04 0.01 0.01 0.01 0 4.1e-02 2.6e-02 6.4e-02 9.6e-02
3 Adipose mRNA stability Stx5 0.19 0.08 0.0e+00 0.08 0.13 0.14 0.13 1.5e-09 1.3e-14 8.7e-15 5.5e-14
4 Adipose isoform ratio NM_031704.2 0.03 0.02 3.1e-03 0 0 0 0 7.5e-02 9.1e-02 1.6e-01 2.6e-01
5 Adipose isoform ratio XM_006230997.3 0.03 0.02 1.4e-03 0.01 0.01 0.01 0 1.3e-02 4.2e-02 6.9e-02 7.8e-02
6 PL mRNA stability Stx5 0.07 0.04 1.9e-09 0.1 0.08 0.09 0.09 1.4e-10 3.9e-09 1.3e-09 3.0e-10
7 BLA mRNA stability Stx5 0.07 0.05 1.4e-03 0.06 0.06 0.05 0.06 4.8e-04 5.6e-04 1.1e-03 6.0e-04
8 Adipose gene expression Stx5 0.08 0.04 2.8e-08 0.06 0.05 0.05 0.05 2.0e-07 1.4e-06 2.3e-06 2.2e-06
9 Adipose alternative TSS NM_031704.2 0.04 0.03 2.0e-03 0.01 0.01 0 0 5.0e-02 6.7e-02 1.4e-01 1.8e-01
10 Brain mRNA stability Stx5 0.07 0.04 9.6e-06 0.03 0.05 0.04 0.04 8.8e-04 2.4e-05 1.5e-04 1.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.20.41.3-0.6-0.41.1-0.70.70.80.6-0.5-0.3-0.2
Area under the delay curve0.00.00.1-0.10.00.3-0.00.00.00.10.0-0.30.1
BMI with tail2.16.614.3-2.7-2.13.8-2.62.62.62.6-2.5-2.70.7
BMI without tail1.02.02.9-1.5-1.31.6-1.31.31.31.4-1.4-1.71.1
Body weight3.514.517.8-4.1-3.84.1-3.93.93.83.8-3.8-4.22.6
Weight adjusted by age1.61.82.6-1.5-1.21.6-1.41.41.61.4-1.4-1.30.3
Bone surface1.73.06.5-1.8-1.42.5-1.91.91.91.8-1.7-1.0-0.2
Bone volume0.81.33.8-1.1-0.71.9-1.21.21.21.1-1.0-0.3-0.7
Breakpoint value in progressive ratio session1.92.12.6-1.5-1.61.1-1.61.61.51.6-1.6-1.20.8
Number of licking bursts0.00.00.0-0.10.10.00.1-0.1-0.0-0.20.1-0.0-0.1
Context. condit. distance diff. score0.30.40.60.80.7-0.40.8-0.8-0.7-0.50.60.7-0.2
Locomotion velocity, session 10.10.10.50.2-0.1-0.20.1-0.10.00.1-0.1-0.20.7
Locomotion distance, session 10.40.60.8-0.7-0.70.8-0.60.60.70.9-0.9-0.80.8
Locomotion velocity, session 22.73.14.0-1.8-1.71.9-1.71.71.62.0-2.0-1.91.1
Locomotion distance, session 20.20.30.8-0.5-0.60.3-0.30.30.40.6-0.6-0.80.9
Locomotion velocity, session 30.30.31.3-0.5-0.21.2-0.30.30.30.5-0.5-0.70.1
Locomotion distance, session 30.10.10.3-0.2-0.20.2-0.20.20.00.1-0.1-0.60.6
Stereotopy head waving bouts, day 30.20.20.70.40.60.50.5-0.5-0.5-0.10.10.3-0.9
Stereotopy head waving duration, day 30.20.20.40.50.60.10.6-0.6-0.6-0.20.20.6-0.5
Locomotion velocity, session 70.10.10.30.20.30.30.3-0.3-0.3-0.00.10.1-0.6
Locomotion distance, session 70.10.10.20.40.3-0.10.5-0.5-0.4-0.30.4-0.10.1
Stereotopy head waving bouts, day 70.20.20.7-0.3-0.00.8-0.30.30.30.5-0.50.6-0.8
Stereotopy head waving duration, day 71.72.03.0-1.5-1.41.7-1.61.61.61.6-1.6-0.80.4
Locomotion velocity, session 80.10.20.70.3-0.0-0.70.3-0.3-0.30.00.0-0.00.8
Locomotion distance, session 80.20.30.50.60.70.00.7-0.7-0.6-0.40.40.6-0.6
Degree of sensitization distance0.10.10.50.30.50.40.3-0.3-0.2-0.30.30.2-0.7
Degree of sensitization stereotypy0.80.91.6-1.0-0.81.3-1.01.01.01.2-1.2-0.1-0.3
Conditioned locomotion0.60.70.8-0.7-0.90.8-0.90.90.80.8-0.8-0.80.7
Cocaine response after cond. corrected0.60.71.11.10.8-1.00.9-0.9-1.0-0.70.80.50.2
Cocaine response after cond. not corrected0.40.50.90.90.7-0.80.7-0.7-0.8-0.60.60.40.0
Cocaine response before conditioning0.30.40.5-0.7-0.50.7-0.60.60.70.7-0.7-0.3-0.3
Saline control response2.53.34.1-1.9-1.91.4-1.81.81.71.7-1.9-2.01.9
Bone: connectivity density1.52.34.2-1.6-1.42.0-1.61.61.71.7-1.5-1.20.5
Bone: cortical apparent density0.50.61.0-0.8-1.00.1-0.80.80.91.0-0.9-0.60.9
Bone: cortical area0.81.22.4-1.2-0.91.6-1.21.21.11.1-1.2-0.9-0.0
Bone: cortical porosity0.00.10.30.30.1-0.50.2-0.2-0.2-0.10.10.2-0.0
Bone: cortical porosity0.10.10.2-0.1-0.3-0.3-0.20.20.10.2-0.2-0.10.4
Bone: cortical thickness3.25.26.6-2.4-2.61.3-2.22.22.22.3-2.4-2.52.5
Bone: cortical thickness0.70.82.4-0.7-1.00.1-0.70.70.70.8-0.8-1.21.6
Bone: cortical tissue density0.60.81.2-0.9-1.10.2-0.80.81.01.1-1.0-0.71.0
Condit. Reinf. active minus inactive responses1.01.11.4-1.1-1.11.0-1.11.11.21.2-1.2-0.90.6
Condit. Reinf. active-inactive response ratio0.40.50.6-0.6-0.80.3-0.70.70.80.7-0.7-0.40.8
Condit. Reinf. active responses0.91.12.1-1.0-0.81.4-1.01.01.11.2-1.2-0.7-0.1
Condit. Reinf. inactive responses0.20.21.5-0.00.30.80.0-0.00.0-0.0-0.00.2-1.2
Incentive salience index mean1.31.52.2-1.3-1.11.5-1.21.21.31.3-1.3-1.10.5
Condit. Reinf. lever presses0.70.92.0-1.0-0.81.4-0.90.91.01.0-1.0-0.90.2
Condit. Reinf. active minus inactive responses0.40.51.50.60.8-0.20.6-0.6-0.6-0.60.51.1-1.2
Condit. Reinf. active-inactive response ratio1.31.35.30.81.20.10.8-0.8-0.8-0.70.61.7-2.3
Condit. Reinf. active responses0.00.00.0-0.10.00.1-0.00.0-0.0-0.0-0.10.1-0.2
Condit. Reinf. inactive responses0.40.52.3-0.4-0.6-0.3-0.40.40.30.2-0.3-1.11.5
Condit. Reinf. lever presses0.81.11.9-1.2-0.91.4-1.21.21.11.0-1.1-0.70.1
Condit. Reinf. lever reinforcers received0.10.10.2-0.4-0.30.4-0.40.40.30.3-0.4-0.1-0.0
Conditioned reinforcement - actives2.32.34.11.61.7-1.21.4-1.4-1.4-1.31.31.9-2.0
Conditioned reinforcement - inactives1.11.34.01.01.3-0.31.0-1.0-0.9-0.90.81.3-2.0
Conditioned locomotion2.22.64.21.81.9-0.91.5-1.5-1.5-1.41.51.9-2.0
Patch foraging indifference point 0 sec0.50.81.0-1.0-0.91.0-0.90.90.90.9-1.0-0.70.6
Patch foraging indifference point AUC2.22.63.6-1.7-1.61.7-1.81.81.81.9-1.6-1.10.1
Delay disc. indifference point, 0s delay0.20.20.40.40.6-0.10.7-0.7-0.6-0.50.5-0.0-0.0
Delay disc. indifference point, 16s delay0.10.10.5-0.4-0.10.7-0.30.30.30.3-0.2-0.2-0.4
Delay disc. indifference point, 2s delay0.20.20.60.40.70.10.4-0.4-0.5-0.40.50.4-0.7
Delay disc. indifference point, 24s delay0.20.20.7-0.3-0.40.2-0.40.40.20.2-0.2-0.60.8
Delay disc. indifference point, 4s delay0.30.41.0-0.5-0.50.4-0.40.40.40.5-0.5-0.91.0
Delay disc. indifference point, 8s delay0.30.30.50.60.5-0.70.6-0.6-0.7-0.60.70.20.3
Indifference point function ln k3.34.66.02.52.1-2.32.3-2.3-2.5-2.42.31.50.0
Indifference point function log k3.34.66.02.52.1-2.32.3-2.3-2.5-2.42.31.50.0
Patch foraging total patch changes 0 sec0.50.91.2-0.9-1.00.7-0.90.90.80.9-0.9-0.91.1
Patch foraging total patch changes 12 sec6.48.310.7-3.0-3.02.7-3.13.12.93.3-3.1-2.51.6
Patch foraging total patch changes 18 sec0.60.71.2-0.9-0.80.8-1.01.00.91.1-0.9-0.50.3
Patch foraging total patch changes 24 sec7.39.010.5-3.1-3.13.1-3.23.23.23.1-3.0-2.81.9
Patch foraging total patch changes 6 sec1.21.82.4-1.3-1.31.4-1.51.51.31.4-1.3-1.31.0
Patch foraging time to switch 0 sec0.40.61.9-0.7-0.41.4-0.70.70.70.9-0.9-0.3-0.7
Patch foraging water rate 0 sec0.40.61.20.80.6-1.10.7-0.7-0.7-1.00.90.60.3
Patch foraging water rate 12 sec1.62.44.31.61.3-2.11.6-1.6-1.6-2.01.80.70.6
Patch foraging water rate 18 sec0.70.91.81.00.7-1.10.9-0.9-0.9-1.41.10.10.9
Patch foraging water rate 24 sec1.21.72.51.41.2-1.61.3-1.3-1.4-1.61.40.90.1
Patch foraging water rate 6 sec1.11.62.91.31.0-1.71.4-1.4-1.4-1.61.40.40.6
Seeking ratio, delayed vs. immediate footshock0.00.00.1-0.3-0.10.2-0.10.10.40.00.0-0.30.2
Distance traveled before self-admin2.32.43.1-1.7-1.51.7-1.71.71.71.7-1.6-1.20.4
Distance traveled after self-admin0.30.30.6-0.7-0.60.5-0.70.70.70.4-0.3-0.40.1
Extensor digitorum longus weight6.425.329.8-5.5-5.15.1-5.25.25.25.1-5.0-5.13.4
Bone: elastic displacement0.50.61.90.80.4-1.40.8-0.8-0.6-0.80.80.20.6
Bone: elastic work1.01.33.1-1.0-1.20.4-1.01.01.01.0-1.0-1.51.8
Bone: endosteal estimation1.43.07.61.62.10.21.4-1.4-1.6-1.71.61.7-2.8
Bone: endosteal perimeter2.24.613.31.82.60.11.7-1.7-1.9-2.01.92.3-3.6
Epididymis fat weight0.40.81.40.71.20.00.9-0.9-1.1-1.11.00.4-1.2
Delta time in closed arm before/after self-admin1.71.64.6-1.1-1.40.8-1.01.01.01.1-1.0-1.72.1
Delta time in open arm before/after self-admin1.51.52.3-1.3-1.11.4-1.31.31.31.5-1.5-0.7-0.2
Diff in mean of infusions in LGA sessions1.71.92.8-1.4-1.70.7-1.41.41.41.5-1.5-1.31.4
Delay discount exponential model param0.00.00.10.1-0.0-0.30.1-0.1-0.0-0.1-0.00.2-0.2
Extinction: sum of active levers before priming3.93.84.7-2.1-2.01.9-2.22.22.12.0-2.0-1.81.1
Active lever presses in extinction session 62.52.53.6-1.6-1.71.4-1.61.61.81.9-1.8-1.20.6
Bone: final force1.93.15.1-1.9-1.62.3-1.91.91.91.8-1.9-1.50.5
Bone: final moment1.93.05.0-1.9-1.62.2-1.91.91.91.8-1.8-1.50.5
Food consumed during 24 hour testing period0.10.10.20.20.3-0.10.0-0.0-0.1-0.50.40.4-0.5
Glucose2.94.45.62.12.4-1.22.1-2.1-2.2-2.32.31.9-2.1
Heart weight0.81.21.71.21.2-0.91.2-1.2-1.2-1.31.30.7-0.4
Delay discount hyperbolic model param0.00.00.10.10.0-0.30.1-0.1-0.0-0.10.00.3-0.1
Intermittent access intake day 1-15 change1.31.32.11.11.1-1.21.0-1.0-1.0-1.01.11.4-1.4
Intermittent access intake escalation0.80.81.40.80.9-0.90.7-0.7-0.8-0.70.81.1-1.2
Intermittent access intake escalation 20.10.10.60.10.1-0.1-0.00.00.00.1-0.10.4-0.7
Intermitt. access day 1 inactive lever presses2.12.22.81.41.7-1.01.7-1.7-1.5-1.31.31.6-1.6
Intermitt. access day 15 inactive lever presses0.30.31.5-0.30.21.0-0.10.10.20.3-0.1-0.1-1.2
Intermitt. access escalation Index0.20.20.40.40.4-0.40.5-0.5-0.4-0.60.60.00.3
Intermittent access day 1 total infusions1.01.23.81.01.50.40.9-0.9-0.9-0.70.71.0-2.0
Intermittent access day 15 total infusions3.54.08.22.02.4-1.01.8-1.8-1.8-1.71.72.2-2.9
Intermittent access terminal intake (last 3 days)1.11.25.90.81.30.40.6-0.6-0.7-0.50.41.2-2.4
Intermittent access total infusions1.21.35.01.01.50.10.9-0.9-0.9-0.70.71.2-2.2
Intermittent access day 1 locomotion0.30.31.10.40.80.80.3-0.3-0.3-0.10.10.3-1.1
Intermittent access day 15 total locomotion0.40.42.50.50.80.50.3-0.3-0.3-0.10.20.7-1.6
Intermittent access total locomotion0.70.85.20.41.01.30.2-0.2-0.20.1-0.00.7-2.3
Intermittent access standard deviation1.41.52.51.31.2-1.31.1-1.1-1.1-1.01.01.6-1.3
Left kidney weight0.00.10.5-0.30.10.7-0.10.10.00.0-0.1-0.0-0.7
Right kidney weight0.10.41.3-0.6-0.21.2-0.50.50.50.4-0.4-0.2-0.9
Cocaine induced anxiety0.30.30.6-0.5-0.40.7-0.70.70.50.6-0.6-0.3-0.2
Post-drug Anxiety0.60.60.8-0.8-0.70.9-0.90.90.90.9-0.9-0.6-0.2
Baseline Anxiety1.11.21.6-1.1-1.30.7-1.01.01.11.0-1.0-1.21.2
Tail length1.02.95.4-1.8-2.10.6-1.51.51.51.6-1.6-2.02.3
Length with tail2.38.310.2-3.1-3.12.4-2.92.92.82.8-2.8-3.22.5
Length without tail1.94.25.1-2.2-2.12.1-2.22.22.02.0-2.0-2.31.3
Times rat made contact with spout0.20.31.3-0.4-0.6-0.2-0.40.40.30.2-0.4-0.61.2
Lifetime Intake1.01.13.01.01.4-0.10.9-0.9-1.0-0.80.71.1-1.7
Liver weight, left0.30.40.80.70.6-0.80.5-0.5-0.8-0.80.90.4-0.0
Liver weight, right0.10.10.6-0.10.00.4-0.20.2-0.1-0.20.2-0.80.2
Locomotor activity0.81.22.71.10.7-1.71.1-1.1-1.1-1.31.20.50.9
Locomotor testing distance0.91.42.81.30.8-1.71.3-1.3-1.2-1.31.30.31.1
Locomotor testing rearing0.91.42.11.31.0-1.41.3-1.3-1.3-1.41.30.50.4
Locomotion in novel chamber2.42.96.61.62.0-0.81.6-1.6-1.4-1.61.51.9-2.6
Locomotion in novel chamber post-restriction2.83.44.01.91.9-1.72.0-2.0-1.9-1.81.71.9-1.6
Fecal boli incidents, locomotor time 10.50.52.50.40.70.10.3-0.3-0.3-0.40.41.1-1.6
Change in fecal boli incidents, locomotor task0.70.71.00.90.6-1.01.0-1.0-0.9-0.90.90.00.5
Time >=10cm from walls, locomotor time 12.92.96.91.61.9-0.61.6-1.6-1.4-1.41.52.0-2.6
Bouts of movement, locomotor time 10.20.20.5-0.2-0.7-0.5-0.20.20.40.6-0.6-0.10.6
Total resting periods, locomotor time 10.20.20.4-0.3-0.6-0.3-0.30.30.50.6-0.6-0.10.3
Rest time, locomotor task time 11.31.42.01.11.1-1.31.0-1.0-1.3-1.31.41.2-0.7
Distance moved, locomotor task time 10.20.20.4-0.4-0.40.7-0.40.40.50.6-0.6-0.40.2
Vertical activity count, locomotor time 10.70.71.00.90.9-0.71.0-1.0-0.8-0.80.80.7-0.6
Time >=10cm from walls, locomotor time 20.20.20.90.40.4-0.20.2-0.2-0.2-0.20.20.8-1.0
Bouts of movement, locomotor time 21.51.61.8-1.3-1.40.9-1.31.31.21.2-1.3-1.31.1
Total resting periods, locomotor time 20.70.81.0-1.0-0.90.7-1.01.00.90.8-0.8-0.90.7
Rest time, locomotor task time 23.33.75.21.92.1-1.71.9-1.9-2.1-2.12.31.9-1.4
Distance moved, locomotor task time 20.50.51.0-0.6-0.90.3-0.70.70.80.9-1.0-0.50.8
Vertical activity count, locomotor time 20.20.21.30.2-0.3-0.90.3-0.3-0.1-0.10.1-0.21.1
Light reinforcement 10.10.10.40.30.3-0.70.3-0.3-0.4-0.30.30.20.1
Light reinforcement 20.50.74.30.30.80.40.5-0.5-0.4-0.30.41.0-2.1
Bone: marrow area1.53.37.81.72.20.11.6-1.6-1.7-1.81.81.8-2.8
Bone: maximum diameter0.20.41.7-0.40.01.3-0.50.50.30.4-0.60.1-1.2
Bone: maximum force2.54.39.9-2.2-1.63.1-2.22.22.22.1-2.1-1.6-0.1
Bone: maximum moment2.34.09.1-2.1-1.63.0-2.12.12.12.0-2.0-1.70.0
Mean time between licks in bursts1.01.44.7-0.8-1.20.2-1.01.00.90.6-0.7-1.82.2
Mean num. licks in bursts0.10.10.30.2-0.1-0.50.0-0.0-0.2-0.10.1-0.00.6
Cd content in liver1.31.53.11.31.3-0.80.9-0.9-1.1-1.11.11.8-1.3
Co content in liver1.92.26.51.51.0-2.61.4-1.4-1.5-1.51.50.80.8
Cu content in liver0.20.31.2-0.4-0.60.0-0.50.50.40.4-0.4-0.41.1
Fe content in liver0.10.10.30.10.20.10.1-0.1-0.10.1-0.10.5-0.5
K content in liver1.01.02.5-1.1-0.81.6-0.90.91.00.9-1.0-1.0-0.0
Mg content in liver0.30.31.6-0.6-0.31.3-0.40.40.50.5-0.5-0.4-0.3
Mn content in liver2.02.23.0-1.7-1.51.7-1.61.61.71.5-1.5-1.00.5
Na content in liver0.60.61.3-0.9-0.61.1-0.70.70.70.9-0.9-0.5-0.2
Rb content in liver1.51.82.41.41.4-1.11.5-1.5-1.5-1.51.51.1-0.6
Se content in liver0.40.41.4-0.6-0.11.1-0.50.50.50.4-0.50.4-1.2
Sr content in liver5.75.26.3-2.5-2.42.0-2.42.42.42.4-2.5-2.21.4
Zn content in liver4.14.65.8-2.2-2.12.3-2.22.22.22.4-2.4-1.90.9
Bone: minimum diameter0.81.55.40.91.50.70.9-0.9-1.0-1.21.01.1-2.3
Time in familiar zone, hab. session 10.10.10.2-0.2-0.20.5-0.40.40.40.2-0.2-0.50.2
Time in novel zone, hab. session 11.41.42.21.21.1-1.51.3-1.3-1.3-1.21.30.9-0.2
Total zone transitions, hab. session 10.20.30.4-0.6-0.60.4-0.50.50.50.6-0.7-0.50.5
Total locomotion distance, hab. session 10.10.20.80.30.40.30.3-0.3-0.3-0.10.10.4-0.9
Locomotion velocity, hab. session 10.10.10.4-0.3-0.20.6-0.20.20.30.5-0.5-0.2-0.4
Time in familiar zone, hab. session 20.40.41.20.50.2-1.10.4-0.4-0.4-0.80.8-0.30.8
Time in novel zone, hab. session 20.50.51.3-0.7-0.51.2-0.60.60.60.8-0.8-0.2-0.2
Total zone transitions, hab. session 21.51.92.6-1.4-1.31.4-1.31.31.31.4-1.4-1.61.3
Total locomotion distance, hab. session 20.10.20.5-0.3-0.30.7-0.20.20.20.4-0.4-0.70.2
Locomotion velocity, hab. session 20.10.10.4-0.2-0.00.7-0.10.10.00.3-0.3-0.4-0.2
Novel to familiar place preference ratio1.92.03.1-1.6-1.31.8-1.51.51.51.5-1.5-1.00.2
Novelty place preference1.11.12.0-1.3-1.01.4-1.21.21.21.1-1.1-0.70.0
Time in novel zone, NPP test1.21.22.1-1.3-1.01.5-1.21.21.21.1-1.1-0.80.1
Total zone transitions, NPP test1.11.62.2-1.3-1.31.1-1.21.21.31.5-1.5-1.21.2
Total locomotion distance, NPP test0.10.10.2-0.1-0.20.3-0.00.00.00.5-0.5-0.40.4
Locomotion velocity, NPP test0.00.00.1-0.0-0.10.10.1-0.1-0.10.4-0.4-0.20.3
Intraocular pressure0.10.10.50.20.3-0.60.3-0.3-0.2-0.30.40.7-0.3
Delta distance traveled before/after self-admin0.60.61.20.80.6-1.10.7-0.7-0.8-1.01.10.40.2
Delta ambulatory time before/after self-admin1.01.12.01.00.8-1.41.0-1.0-1.1-1.31.30.60.2
Parametrial fat weight1.53.05.21.72.1-0.71.7-1.7-1.6-1.71.71.7-2.3
Pavlov. Cond. lever latency1.11.42.81.21.0-1.71.2-1.2-1.3-1.31.31.0-0.1
Pavlov. Cond. magazine entry latency1.01.33.0-1.1-0.91.7-1.21.21.31.2-1.2-0.8-0.3
Pavlov. Cond. change in total contacts0.50.51.3-0.4-0.21.2-0.60.60.70.7-0.70.2-1.0
Pavlov. Cond. index score0.60.71.4-0.8-0.71.2-1.01.01.01.0-1.0-0.5-0.2
Pavlov. Cond. latency score0.50.61.2-0.7-0.61.1-0.90.90.80.9-0.9-0.5-0.1
Pavlov. Cond. lever contacts0.30.30.8-0.5-0.40.9-0.60.60.50.5-0.5-0.6-0.1
Pavlov. Cond. magazine entry number0.70.81.20.80.8-1.01.0-1.0-1.0-1.11.10.30.2
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.1-0.1-0.1-0.00.00.20.3-0.30.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.80.91.7-0.9-0.81.3-1.11.11.11.1-1.1-0.6-0.2
Pavlov. Cond. response bias0.70.91.6-0.9-0.71.2-1.01.01.11.0-1.0-0.6-0.2
Pavlov. Cond. lever latency0.50.61.40.80.5-1.20.9-0.9-0.8-0.70.80.50.0
Pavlov. Cond. magazine entry latency4.65.36.7-2.4-2.32.1-2.42.42.42.5-2.6-2.11.4
Pavlov. Cond. change in total contacts1.52.03.3-1.5-1.11.8-1.71.71.51.5-1.5-0.8-0.2
Pavlov. Cond. index score2.63.44.7-1.9-1.72.2-2.12.12.02.0-2.0-1.40.4
Pavlov. Cond. latency score2.43.04.5-1.8-1.52.1-1.91.91.91.9-1.9-1.30.2
Pavlov. Cond. lever contacts0.40.50.8-0.7-0.60.8-0.90.90.80.7-0.8-0.40.1
Pavlov. Cond. magazine entry number7.38.910.93.13.0-3.03.3-3.3-3.2-3.33.32.6-1.5
Pavlov. Cond. intertrial magazine entries1.82.32.61.51.5-1.51.6-1.6-1.6-1.51.51.6-1.2
Pavlov. Cond. lever-magazine prob. diff.3.03.94.9-2.0-1.82.2-2.22.22.12.1-2.2-1.50.6
Pavlov. Cond. response bias1.62.23.0-1.6-1.41.6-1.71.71.61.5-1.6-1.20.6
Time in closed arm before self-admin0.10.11.00.00.30.30.0-0.0-0.1-0.10.10.4-1.0
Time in closed arm after self-admin0.50.50.80.70.7-0.70.8-0.8-0.8-0.90.90.4-0.0
Time in open arm before self-admin1.01.12.51.00.6-1.61.1-1.1-1.0-1.11.10.21.2
Time in open arm after self-admin0.10.10.5-0.1-0.4-0.4-0.20.20.10.3-0.3-0.30.7
Bone: periosteal estimation0.30.63.40.10.71.30.0-0.0-0.2-0.20.10.5-1.9
Bone: periosteal perimeter0.20.42.30.00.50.9-0.00.0-0.2-0.10.00.3-1.5
Bone: post-yield work0.91.37.40.51.21.40.2-0.2-0.3-0.40.51.1-2.7
Progressive ratio test 1 active lever presses2.12.23.11.71.6-1.21.5-1.5-1.5-1.31.11.8-1.6
Progressive ratio test 1 breakpoint2.42.53.51.81.7-1.41.6-1.6-1.6-1.41.21.9-1.6
Progressive ratio test 1 inactive lever presses0.00.00.1-0.1-0.10.3-0.00.00.10.3-0.4-0.30.2
Progressive ratio test 2 active lever presses1.92.14.81.51.7-0.71.3-1.3-1.3-1.11.01.7-2.2
Progressive ratio test 2 breakpoint2.93.35.61.92.1-1.21.7-1.7-1.7-1.51.52.1-2.4
Progressive ratio test 2 inactive lever presses0.91.14.10.81.30.10.9-0.9-0.9-0.50.51.1-2.0
Incentive Sensitization - Responses0.20.20.8-0.20.00.8-0.30.30.30.4-0.3-0.0-0.9
Incentive Sensitization - Breakpoint0.20.21.1-0.10.20.7-0.20.20.20.3-0.20.1-1.0
Sum of active levers in priming session hrs 5-61.01.01.5-1.1-1.00.9-1.11.11.11.2-1.2-0.3-0.4
Progressive ratio0.10.10.4-0.30.20.6-0.20.20.3-0.10.0-0.1-0.6
Food seeking constrained by brief footshock0.10.20.30.20.2-0.50.5-0.5-0.2-0.50.5-0.20.5
Seeking ratio, punishment vs. effort0.20.31.10.4-0.1-0.80.4-0.4-0.5-0.20.2-0.11.0
Retroperitoneal fat weight2.47.910.32.93.2-1.82.9-2.9-3.0-3.13.12.5-2.5
Reaction time number correct0.70.91.9-1.0-1.00.6-0.90.90.90.6-0.6-1.31.4
Reaction time mean minus median0.30.40.7-0.6-0.50.6-0.80.80.70.7-0.60.1-0.8
Reaction time mean minus median AUC0.10.10.2-0.3-0.4-0.1-0.50.50.40.3-0.20.1-0.2
Reaction time num false alarms0.40.51.70.60.1-1.20.5-0.5-0.6-0.50.4-0.11.3
Reaction time num false alarms AUC0.40.53.40.0-0.5-0.9-0.10.1-0.10.0-0.1-0.61.8
Reaction time trials correct on left0.70.91.9-1.0-1.00.6-0.90.90.90.6-0.6-1.31.4
Reaction time trials on left0.71.02.1-1.0-1.10.6-1.01.00.90.6-0.6-1.31.4
Reaction time mean0.10.20.80.30.2-0.2-0.00.0-0.10.10.00.8-0.9
Reaction time mean AUC0.20.21.00.40.4-0.30.1-0.1-0.2-0.10.20.9-1.0
Median of all reaction times0.10.10.40.10.00.1-0.20.20.10.3-0.20.5-0.6
Reaction time omissions0.10.10.3-0.1-0.5-0.4-0.40.40.30.4-0.20.00.6
Reaction time false alarm rate0.20.31.10.70.2-1.10.5-0.5-0.6-0.40.30.20.7
Reaction time premature initiation rate4.25.79.2-2.4-2.52.0-2.32.32.22.2-2.3-3.02.6
Reaction time premature initiations5.68.012.8-2.9-3.02.0-2.72.72.62.5-2.5-3.63.3
Std. dev. reaction times0.10.20.80.30.2-0.60.0-0.0-0.2-0.10.20.9-0.8
Reaction time trials completed0.71.02.1-1.0-1.10.6-1.01.00.90.6-0.6-1.31.4
Reaction time trials AUC0.50.81.8-0.9-0.90.5-0.80.80.80.5-0.5-1.31.3
Run reversals in cocaine runway, females1.00.91.8-0.8-0.81.0-0.80.80.80.8-0.8-1.41.3
Run reversals in cocaine runway, males0.60.60.90.80.7-1.00.8-0.8-0.8-0.80.80.6-0.2
Latency to leave start box in cocaine runway0.30.40.90.60.80.10.4-0.4-0.6-0.60.60.7-1.0
Latency to leave start box in cocaine runway, F0.00.00.2-0.10.00.4-0.20.20.10.1-0.10.1-0.3
Latency to leave start box in cocaine runway, M3.23.13.81.91.9-1.41.7-1.7-1.9-1.91.81.7-1.4
Std. dev. time between licks in bursts0.30.31.10.40.1-0.80.3-0.3-0.4-0.60.5-0.51.0
Total sessions with >9 infusions1.61.72.71.51.6-0.81.3-1.3-1.3-1.31.31.2-1.3
Short access day 1 total inactive lever presses0.80.91.41.11.2-0.41.0-1.0-0.9-1.00.80.9-1.0
Short access day 10 total inactive lever presses2.32.63.31.61.6-1.71.8-1.8-1.7-1.71.81.4-0.4
Short access day 1 total infusions0.80.81.41.01.2-0.41.0-1.0-1.0-1.00.80.7-0.9
Short access day 10 total infusions0.40.41.60.50.90.50.4-0.4-0.4-0.30.30.5-1.3
Short access total infusions0.40.40.90.70.90.00.7-0.7-0.7-0.50.50.5-0.8
Short access day 1 locomotion0.10.10.7-0.10.20.9-0.20.20.20.2-0.2-0.2-0.4
Short access day 10 total locomotion0.10.10.5-0.00.20.7-0.00.00.10.2-0.1-0.1-0.6
Short access total locomotion0.20.21.2-0.3-0.01.1-0.30.30.40.5-0.5-0.4-0.3
One hour access (0.3 mA shock)4.04.76.92.22.5-1.32.2-2.2-2.2-2.01.92.3-2.6
Compulsive drug intake1.81.87.6-1.2-1.60.1-0.90.91.00.8-0.7-1.72.8
One hour access (shock baseline)5.76.613.42.62.9-1.52.4-2.4-2.4-2.12.03.0-3.7
Social response proportion0.10.20.4-0.5-0.40.4-0.30.30.20.3-0.3-0.60.5
Social responses0.10.20.9-0.3-0.5-0.3-0.20.20.10.2-0.1-0.61.0
Social time0.10.10.7-0.0-0.2-0.60.1-0.1-0.2-0.20.2-0.40.8
Soleus weight2.67.59.02.92.9-2.53.0-3.0-3.0-2.82.82.5-1.7
Bone: stiffness0.81.23.1-1.2-0.71.8-1.21.21.11.0-1.1-0.6-0.5
Tibialis anterior weight9.733.138.5-6.2-6.05.5-6.06.06.06.1-6.1-5.53.7
Time to tail flick, vehicle, before self-admin0.60.62.0-0.7-0.31.4-0.70.70.60.8-0.8-0.5-0.5
Time to tail flick, vehicle, after self-admin0.40.40.8-0.6-0.60.7-0.60.60.60.6-0.6-0.90.8
Time to tail flick, test, before self-admin0.30.31.1-0.5-0.31.0-0.60.60.40.3-0.3-0.80.4
Time to tail flick, test, after self-admin0.10.10.10.20.3-0.30.3-0.3-0.4-0.30.30.3-0.1
Delta time to tail flick, vehicle, before/after SA0.10.10.5-0.0-0.2-0.20.0-0.00.00.00.0-0.30.7
Delta time to tail flick, test, before/after SA0.10.10.60.2-0.1-0.70.2-0.2-0.10.00.00.4-0.0
Tibia length1.33.87.0-2.1-1.62.6-2.02.02.02.3-2.3-0.9-0.6
Ambulatory time before self-admin1.91.92.7-1.5-1.31.5-1.41.41.61.6-1.6-1.00.0
Ambulatory time after self-admin0.20.30.6-0.5-0.30.8-0.70.70.60.3-0.3-0.2-0.5
Bone: tissue strength0.20.20.50.30.5-0.50.5-0.5-0.4-0.60.70.3-0.1
Total heroin consumption3.74.45.8-2.2-2.41.4-2.22.22.22.2-2.2-1.91.9
Bone: trabecular number0.61.02.7-1.0-0.71.7-1.11.11.21.0-0.9-0.4-0.2
Bone: trabecular spacing0.40.51.60.60.3-1.30.6-0.6-0.7-0.60.6-0.00.8
Bone: trabecular thickness0.30.41.50.60.7-0.10.4-0.4-0.3-0.60.60.8-1.2
Bone: trabecular tissue density4.46.18.32.62.4-2.92.6-2.6-2.6-2.32.42.7-1.4
Water consumed over 24 hours0.50.61.2-0.9-0.90.3-0.80.80.80.5-0.6-0.91.1
Number of responses in last shaping day0.10.10.40.1-0.1-0.2-0.10.1-0.1-0.0-0.0-0.10.7