Hub : Genes

Stx5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Stx5 0.07 0.04 4.6e-07 0.05 0.04 0.04 0.04 3.0e-06 1.2e-05 1.0e-05 1.4e-05
2 Adipose isoform ratio NM_031704.2 0.03 0.02 3.8e-03 0 0 0 0 8.1e-02 7.5e-02 1.7e-01 2.3e-01
3 Adipose alternative TSS NM_031704.2 0.04 0.03 1.3e-03 0.01 0.01 0 0 4.1e-02 2.9e-02 8.3e-02 1.0e-01
4 PL mRNA stability Stx5 0.07 0.04 1.0e-09 0.1 0.09 0.1 0.1 1.7e-10 3.0e-10 7.1e-11 5.5e-11
5 Adipose mRNA stability Stx5 0.19 0.08 0.0e+00 0.08 0.13 0.13 0.12 6.1e-09 2.2e-14 2.0e-14 1.1e-13
6 Adipose alternative TSS XM_006230997.4 0.04 0.03 7.4e-04 0.01 0.01 0 0.01 1.0e-02 2.4e-02 8.7e-02 6.3e-02
7 Adipose isoform ratio XM_006230997.4 0.03 0.02 1.7e-03 0.01 0.01 0.01 0 2.7e-02 4.8e-02 6.6e-02 1.4e-01
8 Brain mRNA stability Stx5 0.08 0.04 1.2e-06 0.03 0.07 0.06 0.05 7.9e-04 8.0e-07 4.9e-06 1.4e-05
9 BLA mRNA stability Stx5 0.08 0.05 9.3e-04 0.06 0.06 0.05 0.06 3.3e-04 7.3e-04 1.0e-03 5.7e-04
10 NAcc mRNA stability Stx5 0.1 0.05 0.0e+00 0.14 0.12 0.12 0.13 2.6e-20 1.6e-17 3.6e-18 2.6e-19
11 OFC mRNA stability Stx5 0.18 0.12 8.3e-03 0.02 0.07 0.07 0.04 1.1e-01 8.4e-03 8.9e-03 3.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.40.71.7-0.60.50.5-0.81.30.80.8-0.20.70.7-1.2
Area under the delay curve0.00.00.2-0.10.10.1-0.10.40.10.10.20.20.1-0.5
BMI with tail2.37.916.7-2.72.22.1-2.74.12.82.80.52.82.7-4.1
BMI without tail0.31.32.9-1.21.01.0-1.01.51.01.00.91.21.0-1.7
Body weight3.213.919.8-4.03.53.4-3.84.43.83.82.03.83.7-4.5
Weight adjusted by age0.41.11.5-1.10.90.9-1.21.21.11.10.21.01.0-1.1
Bone surface2.24.38.1-2.11.71.6-2.12.82.22.20.12.12.1-2.5
Bone volume1.01.94.8-1.30.90.8-1.42.21.41.4-0.51.31.3-1.8
Breakpoint value in progressive ratio session1.42.53.3-1.61.81.8-1.71.21.71.71.21.71.7-1.1
Number of licking bursts0.00.00.0-0.20.00.0-0.20.2-0.0-0.00.0-0.1-0.1-0.1
Context. condit. distance diff. score0.30.40.80.9-0.7-0.70.8-0.4-0.7-0.7-0.3-0.5-0.50.2
Locomotion velocity, session 10.10.10.40.30.00.00.2-0.2-0.1-0.10.70.10.1-0.1
Locomotion distance, session 10.40.61.2-0.40.70.7-0.50.80.60.60.70.91.0-1.1
Locomotion velocity, session 22.42.94.0-1.71.71.7-1.71.71.61.61.02.02.0-1.8
Locomotion distance, session 20.20.20.6-0.30.50.5-0.30.20.30.30.80.60.6-0.5
Locomotion velocity, session 30.30.41.6-0.40.30.2-0.41.20.30.30.00.50.5-1.3
Locomotion distance, session 30.10.10.3-0.30.30.3-0.20.20.20.20.60.10.1-0.3
Stereotopy head waving bouts, day 30.30.30.90.6-0.6-0.70.60.5-0.5-0.5-0.9-0.2-0.2-0.5
Stereotopy head waving duration, day 30.10.20.30.6-0.5-0.50.50.2-0.5-0.5-0.6-0.1-0.1-0.3
Locomotion velocity, session 70.10.10.20.2-0.2-0.20.20.4-0.2-0.2-0.50.10.1-0.4
Locomotion distance, session 70.10.10.20.3-0.3-0.20.3-0.0-0.4-0.40.1-0.2-0.2-0.2
Stereotopy head waving bouts, day 70.20.20.7-0.40.20.2-0.40.80.40.4-0.60.50.5-0.7
Stereotopy head waving duration, day 71.41.82.5-1.41.21.2-1.41.61.41.40.31.41.4-1.5
Locomotion velocity, session 80.10.20.70.4-0.00.00.4-0.7-0.3-0.30.80.0-0.00.3
Locomotion distance, session 80.30.40.80.9-0.8-0.80.8-0.1-0.8-0.8-0.7-0.5-0.5-0.0
Degree of sensitization distance0.10.20.50.2-0.4-0.40.20.5-0.2-0.2-0.7-0.1-0.1-0.6
Degree of sensitization stereotypy0.91.01.7-1.10.80.8-1.11.31.01.0-0.21.11.1-1.1
Conditioned locomotion0.60.70.7-0.80.80.9-0.80.80.90.90.70.80.8-0.8
Cocaine response after cond. corrected0.40.61.31.2-0.7-0.71.1-1.0-0.7-0.70.2-0.7-0.70.6
Cocaine response after cond. not corrected0.30.40.80.9-0.6-0.60.8-0.8-0.6-0.6-0.0-0.5-0.50.5
Cocaine response before conditioning0.40.40.8-0.90.50.5-0.80.70.70.7-0.20.70.7-0.4
Saline control response2.83.94.7-2.22.12.1-2.01.51.91.92.02.12.0-1.7
Bone: connectivity density1.82.94.9-1.61.51.4-1.72.21.81.80.51.71.7-2.2
Bone: cortical apparent density0.20.40.6-0.40.80.8-0.5-0.10.70.70.80.80.7-0.1
Bone: cortical area0.91.42.4-1.41.01.0-1.31.51.21.20.11.21.3-1.3
Bone: cortical porosity0.10.10.40.20.10.10.1-0.6-0.1-0.10.1-0.0-0.00.6
Bone: cortical porosity0.10.10.2-0.00.30.3-0.1-0.40.10.10.50.20.20.3
Bone: cortical thickness3.25.47.4-2.52.72.7-2.41.22.32.32.72.42.4-1.5
Bone: cortical thickness0.50.62.3-0.60.91.0-0.6-0.00.70.71.50.70.7-0.2
Bone: cortical tissue density0.40.60.9-0.60.91.0-0.7-0.00.80.80.90.90.9-0.2
Condit. Reinf. active minus inactive responses1.11.21.4-1.01.11.1-1.21.11.21.20.71.21.2-1.1
Condit. Reinf. active-inactive response ratio0.50.50.7-0.50.80.8-0.70.30.80.80.80.70.7-0.5
Condit. Reinf. active responses0.91.22.1-1.00.90.8-1.11.41.11.1-0.11.21.2-1.3
Condit. Reinf. inactive responses0.20.31.6-0.1-0.3-0.4-0.00.8-0.1-0.1-1.3-0.00.0-0.5
Incentive salience index mean1.31.62.3-1.31.21.1-1.31.51.31.30.51.31.4-1.5
Condit. Reinf. lever presses0.91.32.6-1.30.90.9-1.21.61.11.10.21.21.2-1.5
Condit. Reinf. active minus inactive responses0.10.21.00.3-0.5-0.50.40.0-0.3-0.3-1.0-0.3-0.30.4
Condit. Reinf. active-inactive response ratio0.60.94.60.7-1.0-1.10.70.3-0.7-0.7-2.1-0.6-0.60.3
Condit. Reinf. active responses0.10.10.2-0.40.30.3-0.30.40.30.3-0.00.30.3-0.2
Condit. Reinf. inactive responses0.30.52.3-0.60.70.8-0.5-0.20.60.61.50.40.4-0.1
Condit. Reinf. lever presses1.01.42.5-1.41.00.9-1.31.61.31.30.11.11.1-1.3
Condit. Reinf. lever reinforcers received0.20.30.4-0.60.50.5-0.50.60.60.60.10.60.6-0.3
Conditioned reinforcement - actives0.10.52.80.7-0.7-0.80.5-0.1-0.6-0.6-1.7-0.4-0.40.4
Conditioned reinforcement - inactives0.20.53.40.4-0.6-0.70.10.7-0.2-0.2-1.9-0.1-0.1-0.4
Conditioned locomotion2.13.14.92.1-2.0-2.11.7-0.9-1.7-1.7-2.2-1.6-1.61.0
Patch foraging indifference point 0 sec0.30.81.0-0.90.90.9-0.91.00.90.90.61.00.9-1.0
Patch foraging indifference point AUC0.71.82.4-1.41.41.3-1.41.41.51.50.11.51.5-1.0
Delay disc. indifference point, 0s delay0.30.40.60.7-0.7-0.70.7-0.2-0.7-0.7-0.4-0.6-0.70.0
Delay disc. indifference point, 16s delay0.10.20.5-0.30.10.1-0.30.70.30.3-0.30.30.3-0.6
Delay disc. indifference point, 2s delay0.30.31.00.5-0.7-0.80.50.2-0.5-0.5-1.0-0.4-0.5-0.0
Delay disc. indifference point, 24s delay0.10.10.5-0.30.40.4-0.20.20.30.30.70.30.3-0.4
Delay disc. indifference point, 4s delay0.30.30.8-0.40.50.5-0.40.50.40.40.90.50.4-0.8
Delay disc. indifference point, 8s delay0.20.40.60.7-0.5-0.50.7-0.8-0.7-0.70.2-0.7-0.70.5
Indifference point function ln k1.54.66.32.5-2.2-2.12.4-2.2-2.2-2.2-0.3-2.3-2.31.7
Indifference point function log k1.54.66.32.5-2.2-2.12.4-2.2-2.2-2.2-0.3-2.3-2.31.7
Patch foraging total patch changes 0 sec0.30.91.2-0.91.01.0-0.90.70.90.91.11.01.0-0.8
Patch foraging total patch changes 12 sec5.98.010.1-3.03.03.0-2.92.53.03.01.83.23.1-2.4
Patch foraging total patch changes 18 sec0.40.81.4-0.91.00.9-0.90.81.01.00.41.21.0-0.6
Patch foraging total patch changes 24 sec2.58.510.0-3.02.92.9-3.02.93.23.21.92.93.0-2.9
Patch foraging total patch changes 6 sec1.22.02.3-1.41.41.4-1.41.51.51.51.11.51.4-1.4
Patch foraging time to switch 0 sec0.20.61.8-0.60.30.3-0.61.30.50.5-0.80.80.8-1.1
Patch foraging water rate 0 sec0.20.71.30.9-0.7-0.60.7-1.2-0.7-0.70.2-1.0-0.91.1
Patch foraging water rate 12 sec0.73.04.71.7-1.5-1.41.7-2.2-1.7-1.70.3-2.1-2.01.8
Patch foraging water rate 18 sec0.30.71.50.7-0.7-0.60.7-0.9-0.8-0.80.8-1.2-1.00.5
Patch foraging water rate 24 sec1.21.82.61.5-1.2-1.21.4-1.6-1.4-1.4-0.0-1.5-1.31.4
Patch foraging water rate 6 sec1.42.13.41.4-1.2-1.11.4-1.8-1.5-1.50.5-1.7-1.61.5
Seeking ratio, delayed vs. immediate footshock0.00.10.2-0.30.20.1-0.40.30.20.20.10.20.2-0.3
Distance traveled before self-admin1.32.84.3-1.81.51.4-1.82.11.81.80.21.71.8-1.8
Distance traveled after self-admin0.30.50.9-0.70.90.9-0.90.50.90.90.50.60.7-0.4
Extensor digitorum longus weight6.325.328.9-5.45.15.1-5.44.95.25.23.55.05.0-5.2
Bone: elastic displacement0.40.51.50.7-0.4-0.30.6-1.2-0.6-0.60.6-0.7-0.71.0
Bone: elastic work1.01.33.3-1.01.31.3-1.10.51.11.11.81.11.1-0.8
Bone: endosteal estimation1.02.57.41.3-2.0-2.11.40.5-1.3-1.3-2.7-1.5-1.40.0
Bone: endosteal perimeter1.63.912.81.7-2.4-2.51.70.3-1.7-1.7-3.6-1.8-1.80.4
Epididymis fat weight0.52.58.21.1-2.0-2.01.30.2-1.3-1.3-2.9-1.5-1.60.4
Delta time in closed arm before/after self-admin1.11.13.7-0.81.11.2-0.80.40.80.81.90.91.0-1.0
Delta time in open arm before/after self-admin1.72.02.9-1.41.31.2-1.51.71.51.5-0.21.71.7-1.4
Diff in mean of infusions in LGA sessions1.62.93.9-1.61.92.0-1.71.21.71.71.71.81.9-1.3
Delay discount exponential model param0.00.10.20.1-0.1-0.10.1-0.4-0.1-0.1-0.2-0.2-0.10.5
Extinction: sum of active levers before priming2.74.24.8-2.12.12.0-2.22.12.22.21.12.02.2-2.1
Active lever presses in extinction session 62.92.94.0-1.71.71.7-1.81.81.81.80.52.02.0-1.6
Bone: final force1.62.74.3-1.71.41.4-1.72.11.61.60.41.71.8-2.0
Bone: final moment1.72.84.4-1.81.51.4-1.72.11.71.70.51.71.8-2.0
Food consumed during 24 hour testing period0.00.10.2-0.0-0.3-0.30.00.0-0.2-0.2-0.4-0.5-0.50.4
Glucose2.33.65.01.9-2.2-2.22.0-0.9-1.9-1.9-1.8-2.2-2.21.2
Heart weight0.20.30.60.5-0.7-0.70.60.1-0.5-0.5-0.2-0.8-0.8-0.3
Delay discount hyperbolic model param0.00.00.20.00.00.00.0-0.4-0.0-0.0-0.0-0.1-0.00.4
Intermittent access intake day 1-15 change0.42.34.21.4-1.6-1.71.5-1.2-1.4-1.4-2.0-1.4-1.41.5
Intermittent access intake escalation0.52.84.91.6-1.8-1.81.6-1.3-1.6-1.6-2.2-1.6-1.51.7
Intermittent access intake escalation 20.50.83.00.7-1.0-1.00.8-0.4-0.8-0.8-1.7-0.7-0.70.8
Intermitt. access day 1 inactive lever presses0.11.61.91.3-1.3-1.31.3-1.1-1.4-1.4-1.4-1.0-1.11.3
Intermitt. access day 15 inactive lever presses0.21.03.2-0.80.30.2-0.91.80.80.8-1.30.90.9-1.4
Intermitt. access escalation Index0.30.81.20.9-0.8-0.81.0-1.1-0.9-0.9-0.1-1.0-1.01.0
Intermittent access day 1 total infusions0.41.35.50.9-1.4-1.50.71.0-0.8-0.8-2.3-0.7-0.5-0.8
Intermittent access day 15 total infusions2.25.413.32.3-2.8-2.92.1-0.7-2.2-2.2-3.7-2.2-2.01.2
Intermittent access terminal intake (last 3 days)1.42.411.31.3-1.9-2.01.10.6-1.1-1.1-3.4-1.1-0.9-0.1
Intermittent access total infusions1.82.18.41.4-1.8-1.91.10.4-1.2-1.2-2.9-1.1-1.0-0.1
Intermittent access day 1 locomotion0.30.52.20.5-0.8-0.80.40.9-0.3-0.3-1.5-0.1-0.1-0.9
Intermittent access day 15 total locomotion0.31.06.10.7-1.0-1.10.40.8-0.4-0.4-2.5-0.3-0.2-0.6
Intermittent access total locomotion1.51.810.60.8-1.4-1.50.51.4-0.5-0.5-3.2-0.3-0.2-1.1
Intermittent access standard deviation0.31.32.61.2-1.3-1.31.1-0.7-1.1-1.1-1.6-1.1-1.00.9
Left kidney weight0.10.73.00.6-1.0-1.10.60.5-0.6-0.6-1.7-0.7-0.7-0.2
Right kidney weight0.10.41.80.3-0.7-0.80.40.4-0.4-0.4-1.3-0.5-0.6-0.2
Cocaine induced anxiety0.00.00.2-0.10.20.2-0.20.10.10.1-0.30.40.2-0.0
Post-drug Anxiety0.30.30.6-0.60.60.6-0.70.50.60.60.20.80.5-0.5
Baseline Anxiety0.30.51.4-0.60.70.8-0.70.40.60.61.20.50.5-0.6
Tail length0.31.43.6-1.41.41.4-1.10.31.01.01.91.00.9-0.5
Length with tail1.36.08.2-2.92.72.7-2.61.92.52.52.42.32.4-2.0
Length without tail1.89.510.9-3.33.33.3-3.32.63.23.22.82.93.0-2.8
Times rat made contact with spout0.20.21.3-0.40.50.6-0.4-0.20.30.31.20.10.10.1
Lifetime Intake1.31.64.91.3-1.6-1.61.00.2-1.1-1.1-2.2-1.0-0.9-0.1
Liver weight, left1.01.82.31.3-1.3-1.31.4-1.4-1.3-1.3-0.6-1.5-1.51.5
Liver weight, right1.32.22.91.5-1.6-1.61.6-1.2-1.6-1.6-0.6-1.7-1.71.2
Locomotor activity0.81.32.61.1-0.8-0.71.1-1.6-1.1-1.10.8-1.3-1.31.3
Locomotor testing distance0.61.42.61.3-0.9-0.81.2-1.6-1.2-1.20.8-1.3-1.31.2
Locomotor testing rearing0.41.52.31.2-1.1-1.01.3-1.5-1.3-1.30.3-1.4-1.41.3
Locomotion in novel chamber1.92.64.31.7-1.9-1.91.5-0.9-1.6-1.6-2.1-1.5-1.71.1
Locomotion in novel chamber post-restriction1.03.03.51.9-1.9-1.91.7-1.4-1.7-1.7-1.9-1.7-1.81.6
Fecal boli incidents, locomotor time 10.10.42.00.4-0.7-0.70.40.0-0.4-0.4-1.4-0.4-0.40.4
Change in fecal boli incidents, locomotor task1.11.11.51.2-1.0-1.01.1-1.2-1.2-1.20.0-1.1-1.20.9
Time >=10cm from walls, locomotor time 12.02.57.51.4-1.8-1.91.3-0.3-1.5-1.5-2.7-1.4-1.30.8
Bouts of movement, locomotor time 10.30.30.6-0.30.80.8-0.5-0.60.20.20.80.60.50.6
Total resting periods, locomotor time 10.20.20.4-0.30.60.7-0.5-0.40.30.30.50.60.50.4
Rest time, locomotor task time 11.21.92.61.3-1.4-1.41.5-1.4-1.2-1.2-1.1-1.5-1.51.6
Distance moved, locomotor task time 10.10.40.7-0.60.50.5-0.60.80.60.60.30.60.6-0.9
Vertical activity count, locomotor time 10.10.50.70.8-0.7-0.70.7-0.6-0.8-0.8-0.5-0.7-0.70.5
Time >=10cm from walls, locomotor time 20.00.10.90.1-0.3-0.30.10.0-0.1-0.1-1.0-0.1-0.10.3
Bouts of movement, locomotor time 20.41.41.7-1.31.31.3-1.30.91.31.31.01.21.2-0.9
Total resting periods, locomotor time 20.20.60.8-0.90.90.9-0.90.70.90.90.60.80.8-0.6
Rest time, locomotor task time 22.33.84.42.0-2.1-2.02.0-1.7-2.0-2.0-1.5-2.1-2.11.8
Distance moved, locomotor task time 20.50.71.0-0.81.01.0-0.80.30.90.90.90.90.8-0.4
Vertical activity count, locomotor time 20.10.21.20.10.30.30.1-0.8-0.1-0.11.1-0.0-0.00.6
Light reinforcement 10.00.10.20.1-0.1-0.10.1-0.4-0.1-0.10.1-0.2-0.30.5
Light reinforcement 20.20.54.10.1-0.7-0.80.20.6-0.3-0.3-2.0-0.2-0.4-0.1
Bone: marrow area1.22.97.71.5-2.1-2.21.60.3-1.5-1.5-2.8-1.7-1.60.2
Bone: maximum diameter0.20.51.7-0.50.0-0.0-0.41.30.50.5-1.20.50.5-0.9
Bone: maximum force2.34.69.7-2.31.71.6-2.23.12.22.2-0.02.12.2-2.8
Bone: maximum moment2.54.69.4-2.31.71.6-2.23.12.22.20.12.12.2-2.8
Mean time between licks in bursts0.10.63.4-0.60.80.9-0.7-0.00.60.61.80.40.4-0.5
Mean num. licks in bursts0.00.10.40.3-0.00.00.3-0.6-0.1-0.10.5-0.1-0.10.5
Cd content in liver0.91.02.11.1-1.1-1.11.1-0.5-0.9-0.9-1.5-0.8-0.80.7
Co content in liver1.11.23.91.1-0.6-0.51.0-2.0-1.0-1.00.8-0.9-0.91.6
Cu content in liver0.00.00.20.20.00.00.1-0.4-0.1-0.10.3-0.1-0.10.3
Fe content in liver0.00.00.10.3-0.2-0.20.3-0.1-0.1-0.1-0.1-0.1-0.10.0
K content in liver0.40.40.7-0.90.60.5-0.70.80.50.50.40.60.6-0.9
Mg content in liver0.00.00.2-0.10.00.0-0.10.30.00.00.30.00.0-0.5
Mn content in liver3.23.64.5-2.11.91.8-2.12.12.02.00.81.91.9-1.9
Na content in liver0.40.50.7-0.80.60.6-0.70.80.70.70.20.70.7-0.8
Rb content in liver2.63.13.91.7-1.7-1.71.9-1.9-2.0-2.0-0.6-1.9-1.91.7
Se content in liver0.20.20.7-0.40.0-0.0-0.30.80.30.3-0.80.30.3-0.5
Sr content in liver4.33.74.2-2.02.02.0-2.01.72.02.01.32.02.0-1.7
Zn content in liver2.63.03.6-1.61.81.8-1.71.61.81.81.21.91.9-1.8
Bone: minimum diameter0.71.45.60.8-1.4-1.50.80.8-0.9-0.9-2.4-1.0-1.0-0.3
Time in familiar zone, hab. session 10.10.10.2-0.20.20.2-0.30.50.40.40.10.20.1-0.4
Time in novel zone, hab. session 11.21.42.11.2-1.1-1.01.2-1.4-1.3-1.3-0.2-1.2-1.21.3
Total zone transitions, hab. session 10.20.30.4-0.50.60.6-0.50.30.40.40.60.60.6-0.4
Total locomotion distance, hab. session 10.10.20.80.4-0.4-0.50.30.3-0.3-0.3-0.9-0.1-0.0-0.2
Locomotion velocity, hab. session 10.10.20.4-0.30.20.2-0.30.60.20.2-0.40.50.5-0.6
Time in familiar zone, hab. session 20.30.41.10.3-0.2-0.20.3-1.0-0.3-0.30.8-0.8-0.81.0
Time in novel zone, hab. session 20.50.51.3-0.60.50.5-0.61.10.60.6-0.10.80.9-1.1
Total zone transitions, hab. session 21.31.72.3-1.21.31.3-1.31.31.21.21.11.41.4-1.5
Total locomotion distance, hab. session 20.10.20.5-0.30.20.2-0.30.60.20.20.10.50.5-0.7
Locomotion velocity, hab. session 20.10.10.4-0.10.0-0.0-0.10.60.00.0-0.30.30.4-0.7
Novel to familiar place preference ratio1.62.13.1-1.61.41.4-1.51.81.41.40.31.51.6-1.6
Novelty place preference1.01.32.1-1.31.01.0-1.21.41.11.10.11.11.2-1.3
Time in novel zone, NPP test1.11.42.1-1.31.11.1-1.21.51.11.10.21.21.2-1.3
Total zone transitions, NPP test1.01.52.1-1.11.31.3-1.11.01.11.11.11.41.5-1.3
Total locomotion distance, NPP test0.10.10.30.00.20.2-0.00.2-0.0-0.00.30.50.5-0.4
Locomotion velocity, NPP test0.00.00.20.10.10.10.10.0-0.1-0.10.20.40.4-0.2
Intraocular pressure0.10.10.50.3-0.3-0.20.3-0.6-0.3-0.3-0.2-0.4-0.40.7
Delta distance traveled before/after self-admin0.60.61.70.8-0.3-0.30.6-1.3-0.6-0.60.8-0.9-0.91.0
Delta ambulatory time before/after self-admin0.61.02.41.0-0.6-0.50.9-1.5-0.9-0.90.7-1.1-1.11.3
Parametrial fat weight1.73.910.51.7-2.4-2.51.9-0.2-1.7-1.7-3.2-1.9-1.90.8
Pavlov. Cond. lever latency1.01.22.11.2-0.9-0.91.1-1.4-1.1-1.1-0.2-1.1-1.11.4
Pavlov. Cond. magazine entry latency1.11.53.1-1.30.90.8-1.31.81.31.3-0.41.21.2-1.5
Pavlov. Cond. change in total contacts0.50.61.5-0.70.30.3-0.71.20.70.7-0.90.70.7-0.8
Pavlov. Cond. index score0.81.01.6-1.10.80.8-1.11.31.11.1-0.11.01.0-1.1
Pavlov. Cond. latency score0.60.81.4-1.00.70.7-1.01.21.01.0-0.00.90.9-1.1
Pavlov. Cond. lever contacts0.50.61.3-0.80.60.5-0.81.10.80.80.00.70.8-1.1
Pavlov. Cond. magazine entry number0.91.11.41.1-0.9-0.91.2-1.2-1.2-1.2-0.0-1.1-1.10.9
Pavlov. Cond. intertrial magazine entries0.00.00.2-0.10.20.2-0.2-0.00.10.1-0.20.40.40.2
Pavlov. Cond. lever-magazine prob. diff.0.81.01.9-1.10.80.8-1.11.41.11.1-0.21.01.0-1.1
Pavlov. Cond. response bias1.01.32.0-1.30.90.9-1.21.41.21.2-0.11.21.2-1.2
Pavlov. Cond. lever latency0.60.81.61.0-0.7-0.71.0-1.3-1.1-1.1-0.1-0.8-0.81.0
Pavlov. Cond. magazine entry latency4.66.57.8-2.72.62.6-2.72.42.72.71.42.82.8-2.3
Pavlov. Cond. change in total contacts0.92.33.9-1.61.31.2-1.62.01.81.8-0.11.51.5-1.5
Pavlov. Cond. index score2.53.95.4-2.11.81.7-2.12.32.22.20.52.02.1-2.0
Pavlov. Cond. latency score2.23.55.3-2.01.71.6-2.02.32.12.10.32.02.0-1.9
Pavlov. Cond. lever contacts0.50.71.2-0.90.70.7-0.91.11.01.00.10.70.8-0.8
Pavlov. Cond. magazine entry number7.69.911.83.3-3.2-3.13.3-3.1-3.4-3.4-1.6-3.4-3.42.9
Pavlov. Cond. intertrial magazine entries1.12.32.81.6-1.5-1.51.7-1.5-1.5-1.5-1.2-1.5-1.51.6
Pavlov. Cond. lever-magazine prob. diff.2.94.55.8-2.22.01.9-2.32.42.42.40.62.22.2-2.1
Pavlov. Cond. response bias2.23.03.9-1.91.61.6-1.91.92.02.00.71.71.7-1.7
Time in closed arm before self-admin0.10.21.4-0.0-0.5-0.50.10.4-0.1-0.1-1.2-0.3-0.3-0.1
Time in closed arm after self-admin0.80.91.50.8-1.0-1.01.0-0.9-1.0-1.0-0.4-1.1-1.20.8
Time in open arm before self-admin1.11.33.11.2-0.6-0.51.1-1.8-1.1-1.11.3-1.1-1.11.1
Time in open arm after self-admin0.50.61.3-0.40.91.0-0.70.20.70.71.20.90.9-0.5
Bone: periosteal estimation0.30.63.2-0.1-0.5-0.6-0.01.40.00.0-1.8-0.1-0.0-0.9
Bone: periosteal perimeter0.20.42.2-0.1-0.4-0.5-0.11.10.10.1-1.5-0.00.0-0.6
Bone: post-yield work0.71.16.30.2-0.9-1.00.21.70.00.0-2.5-0.2-0.2-1.1
Progressive ratio test 1 active lever presses0.30.61.61.0-0.9-0.90.7-0.2-0.8-0.8-1.3-0.6-0.50.2
Progressive ratio test 1 breakpoint0.40.61.71.0-0.9-0.90.7-0.2-0.8-0.8-1.3-0.6-0.50.2
Progressive ratio test 1 inactive lever presses0.20.61.3-0.70.60.6-0.81.10.70.7-0.10.90.9-1.1
Progressive ratio test 2 active lever presses1.11.56.01.3-1.5-1.51.0-0.0-1.0-1.0-2.4-0.9-0.80.2
Progressive ratio test 2 breakpoint1.11.45.91.2-1.4-1.50.90.1-0.9-0.9-2.4-0.8-0.70.2
Progressive ratio test 2 inactive lever presses0.41.26.20.9-1.3-1.40.80.4-0.8-0.8-2.5-0.7-0.6-0.0
Incentive Sensitization - Responses0.30.92.5-0.70.40.3-0.81.60.90.9-1.00.80.8-1.4
Incentive Sensitization - Breakpoint0.30.72.2-0.60.20.1-0.71.50.80.8-1.10.70.7-1.2
Sum of active levers in priming session hrs 5-60.90.91.4-1.01.00.9-1.10.81.11.1-0.31.11.2-0.4
Progressive ratio0.10.21.2-0.1-0.4-0.4-0.20.90.00.0-1.1-0.1-0.1-0.6
Food seeking constrained by brief footshock0.00.00.10.2-0.2-0.20.1-0.2-0.3-0.30.1-0.3-0.20.1
Seeking ratio, punishment vs. effort0.10.21.40.20.20.20.3-0.8-0.2-0.21.2-0.1-0.10.4
Retroperitoneal fat weight3.515.620.13.9-4.5-4.54.2-2.7-4.2-4.2-3.7-4.1-4.22.9
Reaction time number correct0.20.71.8-1.00.91.0-1.00.50.90.91.30.50.6-0.5
Reaction time mean minus median0.10.50.9-0.80.70.6-0.80.70.90.9-0.50.80.7-0.3
Reaction time mean minus median AUC0.00.20.3-0.40.50.5-0.5-0.10.50.50.00.30.30.3
Reaction time num false alarms0.30.61.90.9-0.2-0.10.8-1.4-0.5-0.51.3-0.4-0.40.9
Reaction time num false alarms AUC0.20.53.30.30.40.50.3-1.10.10.11.80.00.10.5
Reaction time trials correct on left0.20.71.8-1.00.91.0-1.00.50.90.91.30.50.6-0.5
Reaction time trials on left0.20.81.9-1.01.01.0-1.00.50.90.91.40.50.6-0.5
Reaction time mean0.00.10.60.2-0.1-0.20.1-0.10.10.1-0.80.10.00.4
Reaction time mean AUC0.10.10.90.3-0.3-0.40.2-0.2-0.1-0.1-0.9-0.1-0.20.5
Median of all reaction times0.00.10.40.2-0.2-0.20.1-0.00.10.1-0.70.10.10.2
Reaction time omissions0.30.40.7-0.60.80.8-0.60.00.80.80.60.80.7-0.1
Reaction time false alarm rate0.30.41.30.9-0.3-0.20.8-1.1-0.5-0.50.7-0.3-0.30.7
Reaction time premature initiation rate3.85.96.8-2.62.52.5-2.42.12.52.52.52.32.2-2.5
Reaction time premature initiations2.67.810.8-3.03.03.0-2.82.12.92.93.32.52.5-2.5
Std. dev. reaction times0.00.10.50.3-0.1-0.10.1-0.40.10.1-0.6-0.0-0.10.7
Reaction time trials completed0.20.81.9-1.01.01.0-1.00.50.90.91.40.50.6-0.5
Reaction time trials AUC0.20.61.7-0.90.90.9-0.90.40.80.81.30.40.5-0.5
Run reversals in cocaine runway, females0.40.51.2-0.50.50.5-0.50.80.50.50.90.60.6-1.1
Run reversals in cocaine runway, males0.50.50.90.7-0.6-0.60.7-0.9-0.8-0.8-0.1-0.7-0.70.9
Latency to leave start box in cocaine runway0.40.51.20.6-0.9-1.00.7-0.0-0.6-0.6-1.1-0.7-0.70.1
Latency to leave start box in cocaine runway, F0.00.00.2-0.20.00.0-0.10.40.20.2-0.10.20.2-0.4
Latency to leave start box in cocaine runway, M2.22.12.81.5-1.7-1.71.5-0.9-1.5-1.5-1.5-1.5-1.51.0
Std. dev. time between licks in bursts0.10.21.00.2-0.1-0.00.2-0.8-0.3-0.31.0-0.5-0.50.4
Total sessions with >9 infusions0.81.01.51.2-1.2-1.21.0-0.5-1.0-1.0-1.2-1.0-0.90.5
Short access day 1 total inactive lever presses0.10.10.30.5-0.4-0.40.20.3-0.1-0.1-0.6-0.1-0.2-0.4
Short access day 10 total inactive lever presses0.10.60.90.9-0.7-0.70.9-1.0-0.8-0.8-0.2-0.7-0.80.9
Short access day 1 total infusions0.81.72.51.5-1.6-1.61.3-0.6-1.3-1.3-1.4-1.3-1.20.7
Short access day 10 total infusions0.40.72.90.7-1.1-1.10.60.6-0.6-0.6-1.7-0.5-0.5-0.6
Short access total infusions0.60.91.61.1-1.2-1.30.9-0.0-1.0-1.0-1.2-0.9-0.8-0.0
Short access day 1 locomotion0.30.41.40.8-0.8-0.90.60.1-0.6-0.6-1.2-0.5-0.5-0.0
Short access day 10 total locomotion0.10.41.70.1-0.3-0.4-0.01.10.10.1-1.30.20.2-1.0
Short access total locomotion0.30.42.20.6-0.7-0.80.40.6-0.4-0.4-1.5-0.2-0.2-0.5
One hour access (0.3 mA shock)1.41.75.41.3-1.6-1.71.20.0-1.1-1.1-2.3-0.9-1.00.2
Compulsive drug intake0.91.45.7-1.11.41.5-0.90.01.11.12.40.70.8-0.2
One hour access (shock baseline)1.95.013.22.3-2.6-2.72.1-0.7-2.2-2.2-3.6-1.8-1.81.0
Social response proportion0.00.00.2-0.50.20.2-0.30.10.10.10.40.10.0-0.1
Social responses0.10.20.9-0.40.40.5-0.3-0.30.20.21.00.10.10.3
Social time0.10.20.7-0.00.20.20.1-0.7-0.1-0.10.8-0.2-0.20.6
Soleus weight2.98.510.03.1-3.0-3.03.1-2.7-3.2-3.2-1.8-3.0-3.02.8
Bone: stiffness0.61.22.7-1.20.70.7-1.11.61.01.0-0.51.01.1-1.3
Tibialis anterior weight8.930.734.4-5.95.85.8-5.95.15.85.83.85.85.8-5.2
Time to tail flick, vehicle, before self-admin0.20.31.0-0.30.0-0.0-0.41.00.40.4-0.70.40.4-0.9
Time to tail flick, vehicle, after self-admin0.10.30.8-0.50.40.4-0.50.80.50.50.30.50.5-0.9
Time to tail flick, test, before self-admin0.30.31.5-0.30.20.2-0.51.00.50.50.10.30.3-1.2
Time to tail flick, test, after self-admin0.00.00.1-0.30.10.1-0.30.30.20.2-0.40.20.1-0.1
Delta time to tail flick, vehicle, before/after SA0.20.20.7-0.50.50.6-0.40.20.30.30.80.40.5-0.4
Delta time to tail flick, test, before/after SA0.10.10.6-0.20.20.2-0.1-0.50.10.1-0.10.20.20.8
Tibia length1.43.96.5-2.11.71.6-2.12.52.02.0-0.42.32.2-2.1
Ambulatory time before self-admin0.82.43.8-1.61.31.3-1.71.91.61.6-0.11.61.7-1.6
Ambulatory time after self-admin0.10.20.4-0.40.40.3-0.60.60.50.5-0.20.30.3-0.4
Bone: tissue strength0.30.30.60.3-0.5-0.50.5-0.6-0.6-0.60.0-0.8-0.70.6
Total heroin consumption5.86.99.0-2.73.03.0-2.71.82.72.72.32.82.9-1.9
Bone: trabecular number1.01.84.0-1.31.01.0-1.32.01.41.40.11.31.2-1.9
Bone: trabecular spacing0.60.92.50.7-0.5-0.50.8-1.6-0.9-0.90.6-0.8-0.81.4
Bone: trabecular thickness0.20.21.00.4-0.5-0.50.30.1-0.3-0.3-1.0-0.4-0.40.2
Bone: trabecular tissue density4.37.610.33.0-2.6-2.63.0-3.2-2.9-2.9-1.5-2.6-2.63.1
Water consumed over 24 hours0.40.81.7-1.11.01.0-1.00.40.90.91.30.60.6-0.5
Number of responses in last shaping day0.10.20.8-0.30.50.5-0.30.10.30.30.90.40.4-0.3