Hub : Genes

Fkbp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	intron excision ratio	chr1_204169059_204169847	0.08	0.06	3.8e-03	0.02	0.03	0.01	0.01	2.8e-02	1.3e-02	7.2e-02	6.5e-02
2	PL	intron excision ratio	chr1_204169095_204169229	0.04	0.03	3.1e-03	0.01	0.02	0.02	0.01	1.4e-02	5.4e-03	5.2e-03	7.2e-03
3	Liver	intron excision ratio	chr1_204168318_204168436	0.04	0.03	5.0e-03	0	0	0.01	-0	2.6e-01	2.6e-01	1.5e-02	4.3e-01
4	LHb	intron excision ratio	chr1_204168318_204168436	0.35	0.17	3.3e-03	0.09	0.11	0.13	0.09	4.2e-03	1.3e-03	6.6e-04	3.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.8	1.3	2.0	-1.1	-0.4	-1.4	-1.3
Area under the delay curve	0.4	0.4	0.9	0.2	-0.5	-0.7	-1.0
BMI with tail	3.5	11.3	19.2	-3.1	-0.0	-4.0	-4.4
BMI without tail	1.2	2.5	3.9	-1.4	0.3	-2.0	-2.0
Body weight	3.1	13.0	21.1	-3.8	2.5	-4.6	-3.2
Weight adjusted by age	1.9	2.1	3.9	-2.0	1.4	-1.7	-0.3
Bone surface	4.0	7.0	13.2	-3.6	0.6	-3.5	-1.4
Bone volume	1.9	3.3	6.6	-2.6	-0.2	-2.3	-1.0
Breakpoint value in progressive ratio session	2.3	2.5	4.6	-2.2	1.5	-1.7	0.3
Number of licking bursts	0.2	0.2	0.5	-0.7	0.4	-0.3	-0.0
Context. condit. distance diff. score	1.0	1.2	2.1	1.5	-1.1	1.1	-0.6
Locomotion velocity, session 1	0.3	0.3	0.6	0.4	-0.4	0.4	-0.8
Locomotion distance, session 1	0.6	0.8	2.6	-0.3	-0.4	-0.5	-1.6
Locomotion velocity, session 2	1.6	1.8	2.6	-1.6	1.0	-1.5	-1.1
Locomotion distance, session 2	0.3	0.4	1.0	-0.2	-0.1	-0.6	-1.0
Locomotion velocity, session 3	2.1	2.5	6.6	0.6	-1.6	0.6	-2.6
Locomotion distance, session 3	0.2	0.2	0.6	0.3	-0.4	-0.2	-0.8
Stereotopy head waving bouts, day 3	2.2	2.6	4.7	1.0	-1.8	1.1	-2.2
Stereotopy head waving duration, day 3	1.1	1.3	2.0	0.9	-1.4	1.1	-1.0
Locomotion velocity, session 7	1.1	1.2	2.0	0.6	-1.3	0.7	-1.4
Locomotion distance, session 7	0.7	0.9	2.1	0.8	-0.6	0.5	-1.5
Stereotopy head waving bouts, day 7	0.2	0.2	0.7	-0.3	-0.8	0.0	0.1
Stereotopy head waving duration, day 7	0.9	1.1	2.6	-1.6	0.5	-1.2	-0.1
Locomotion velocity, session 8	0.1	0.1	0.3	-0.3	0.3	-0.6	-0.3
Locomotion distance, session 8	0.7	1.0	2.2	0.4	-1.5	0.2	-1.3
Degree of sensitization distance	0.8	0.8	2.0	0.3	-0.6	0.7	-1.4
Degree of sensitization stereotypy	0.7	0.8	1.9	-1.4	0.1	-1.1	0.3
Conditioned locomotion	0.6	0.6	1.0	-1.0	0.7	-0.9	-0.5
Cocaine response after cond. corrected	1.6	1.8	3.2	1.8	-1.1	1.4	-0.9
Cocaine response after cond. not corrected	1.0	1.1	2.2	1.5	-0.9	0.8	-0.7
Cocaine response before conditioning	1.3	1.6	3.1	-1.3	0.8	-1.8	0.8
Saline control response	2.7	3.5	5.2	-1.9	2.3	-2.2	-0.5
Bone: connectivity density	2.5	3.9	7.4	-2.2	0.6	-2.7	-1.7
Bone: cortical apparent density	0.5	0.7	1.7	-0.2	1.3	-0.2	1.0
Bone: cortical area	0.8	1.1	2.4	-1.5	0.6	-1.2	-0.6
Bone: cortical porosity	0.0	0.0	0.1	-0.1	0.0	0.2	0.2
Bone: cortical porosity	0.2	0.2	0.3	-0.5	0.5	-0.4	0.3
Bone: cortical thickness	2.0	3.3	8.1	-1.5	2.8	-1.6	0.3
Bone: cortical thickness	0.4	0.4	1.3	0.1	1.2	-0.6	-0.3
Bone: cortical tissue density	0.6	0.8	2.0	-0.2	1.4	-0.2	1.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.3	0.5	0.5	-0.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.7	-0.0	0.6	0.5	0.8
Condit. Reinf. active responses	0.1	0.2	0.3	-0.3	-0.0	0.6	-0.5
Condit. Reinf. inactive responses	0.4	0.5	0.9	-0.1	-1.0	0.2	-1.0
Incentive salience index mean	0.2	0.3	0.8	-0.5	0.3	0.1	-0.9
Condit. Reinf. lever presses	0.4	0.6	1.0	-0.9	0.0	-0.7	-1.0
Condit. Reinf. active minus inactive responses	0.3	0.3	0.7	-0.2	-0.8	0.4	0.7
Condit. Reinf. active-inactive response ratio	1.1	1.1	3.8	-0.1	-1.9	0.7	0.4
Condit. Reinf. active responses	0.1	0.1	0.2	-0.4	0.0	-0.1	0.5
Condit. Reinf. inactive responses	0.5	0.6	1.8	-0.1	1.4	-0.7	0.0
Condit. Reinf. lever presses	2.0	2.8	5.4	-2.3	0.8	-2.2	-0.0
Condit. Reinf. lever reinforcers received	0.3	0.4	0.8	-0.9	0.4	-0.5	0.6
Conditioned reinforcement - actives	0.5	0.5	1.0	-0.2	-1.0	-0.2	1.0
Conditioned reinforcement - inactives	1.1	1.2	2.3	1.3	-1.5	0.7	0.5
Conditioned locomotion	3.8	4.5	7.4	2.5	-2.0	2.7	0.6
Patch foraging indifference point 0 sec	0.0	0.1	0.2	0.0	0.4	0.2	-0.2
Patch foraging indifference point AUC	2.8	3.2	6.9	-2.6	1.7	-1.7	-0.0
Delay disc. indifference point, 0s delay	1.1	1.2	2.5	0.8	-1.4	-0.1	-1.6
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	0.4	-0.5	-0.3	-0.6
Delay disc. indifference point, 2s delay	0.5	0.5	1.5	0.0	-1.2	-0.3	-0.7
Delay disc. indifference point, 24s delay	0.3	0.3	0.4	0.5	0.7	0.4	-0.5
Delay disc. indifference point, 4s delay	0.5	0.5	1.6	0.7	-0.2	-0.0	-1.3
Delay disc. indifference point, 8s delay	0.2	0.2	0.4	0.6	-0.5	-0.1	-0.5
Indifference point function ln k	6.2	8.6	17.8	4.2	-2.6	3.1	-0.3
Indifference point function log k	6.2	8.6	17.8	4.2	-2.6	3.1	-0.3
Patch foraging total patch changes 0 sec	0.1	0.2	0.5	0.2	0.7	0.3	-0.1
Patch foraging total patch changes 12 sec	4.0	5.2	7.6	-2.8	2.7	-2.3	-0.9
Patch foraging total patch changes 18 sec	0.8	1.0	1.8	-1.3	0.9	-1.2	0.3
Patch foraging total patch changes 24 sec	3.3	4.0	6.8	-2.1	2.6	-1.7	-1.3
Patch foraging total patch changes 6 sec	0.7	1.0	1.1	-1.0	1.0	-1.0	-1.0
Patch foraging time to switch 0 sec	1.7	2.7	4.5	-2.0	-0.1	-2.1	-1.4
Patch foraging water rate 0 sec	2.2	3.6	6.4	2.5	-0.5	2.4	1.3
Patch foraging water rate 12 sec	5.9	9.1	17.5	4.2	-1.4	4.1	0.7
Patch foraging water rate 18 sec	2.7	3.6	7.4	2.7	-1.1	2.4	-0.1
Patch foraging water rate 24 sec	2.2	3.1	7.1	2.7	-1.3	1.7	0.9
Patch foraging water rate 6 sec	2.9	4.2	10.1	3.2	-0.8	2.4	0.2
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.7	0.5	0.2	0.8	-0.3
Distance traveled before self-admin	0.7	0.7	1.9	-1.4	0.7	-0.7	-0.2
Distance traveled after self-admin	0.4	0.4	0.5	-0.7	0.7	-0.6	0.5
Extensor digitorum longus weight	4.6	18.1	27.9	-5.3	3.9	-4.7	-2.6
Bone: elastic displacement	1.5	1.7	3.9	2.0	0.1	1.6	0.6
Bone: elastic work	0.5	0.7	2.2	0.1	1.5	-0.5	-0.5
Bone: endosteal estimation	1.6	3.5	9.0	0.3	-3.0	0.5	-2.1
Bone: endosteal perimeter	1.8	3.7	12.0	0.0	-3.5	0.5	-1.6
Epididymis fat weight	0.9	2.2	4.3	1.6	-2.1	0.6	-1.2
Delta time in closed arm before/after self-admin	1.4	1.4	2.8	1.1	0.8	1.0	-1.7
Delta time in open arm before/after self-admin	1.1	1.0	1.8	-1.3	0.8	-1.0	0.8
Diff in mean of infusions in LGA sessions	0.8	0.9	2.6	-0.7	1.6	-0.5	0.4
Delay discount exponential model param	0.3	0.3	0.7	-0.1	0.4	0.7	0.8
Extinction: sum of active levers before priming	3.1	3.1	5.5	-2.3	1.5	-2.0	-0.7
Active lever presses in extinction session 6	2.9	2.8	4.8	-2.2	1.7	-1.8	0.5
Bone: final force	2.3	3.7	6.3	-2.5	1.0	-2.3	-1.5
Bone: final moment	2.1	3.3	5.7	-2.4	1.0	-2.2	-1.4
Food consumed during 24 hour testing period	0.3	0.4	0.7	-0.7	0.6	-0.1	0.8
Glucose	1.8	2.7	7.7	1.4	-2.8	0.6	-0.8
Heart weight	2.3	3.2	6.2	2.5	-1.8	1.7	-0.7
Delay discount hyperbolic model param	0.3	0.3	0.8	-0.1	0.5	0.6	0.9
Intermittent access intake day 1-15 change	0.6	0.6	2.3	0.0	-0.1	0.2	1.5
Intermittent access intake escalation	0.4	0.4	1.6	0.0	-0.1	0.1	1.3
Intermittent access intake escalation 2	0.4	0.4	1.2	-0.4	0.5	0.2	1.1
Intermitt. access day 1 inactive lever presses	1.2	1.3	2.5	1.2	-1.6	1.0	0.4
Intermitt. access day 15 inactive lever presses	0.6	0.7	1.4	0.7	-1.2	0.8	-0.4
Intermitt. access escalation Index	1.9	1.6	3.8	1.9	-0.8	1.1	-1.0
Intermittent access day 1 total infusions	3.9	4.5	11.3	1.8	-3.4	1.0	-1.6
Intermittent access day 15 total infusions	3.3	3.7	9.6	1.9	-3.1	1.2	0.1
Intermittent access terminal intake (last 3 days)	2.1	2.3	7.6	1.0	-2.8	0.4	-0.6
Intermittent access total infusions	2.4	2.7	8.3	1.3	-2.9	0.7	-0.7
Intermittent access day 1 locomotion	3.6	3.8	7.0	1.7	-2.6	0.8	-2.1
Intermittent access day 15 total locomotion	1.2	1.3	3.5	1.2	-1.9	0.5	-0.4
Intermittent access total locomotion	3.0	3.4	9.4	1.3	-3.1	0.6	-1.5
Intermittent access standard deviation	0.7	0.7	1.5	0.6	-0.6	0.8	1.2
Left kidney weight	0.1	0.3	0.7	0.6	-0.8	-0.2	-0.2
Right kidney weight	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.2
Cocaine induced anxiety	0.2	0.2	0.4	-0.7	-0.5	-0.4	0.1
Post-drug Anxiety	1.0	1.1	2.8	-1.7	0.3	-1.1	0.2
Baseline Anxiety	1.5	1.5	3.5	-1.1	1.9	-1.1	-0.4
Tail length	0.8	2.4	6.8	-0.9	2.6	-1.2	0.7
Length with tail	1.6	5.7	9.8	-2.4	3.1	-2.6	-0.8
Length without tail	1.4	3.2	3.8	-1.9	1.8	-1.9	-1.4
Times rat made contact with spout	0.3	0.4	1.3	-0.2	1.1	-0.1	0.4
Lifetime Intake	2.4	2.7	7.3	1.5	-2.7	0.6	-0.8
Liver weight, left	0.2	0.4	1.2	0.3	-1.1	0.4	0.1
Liver weight, right	0.6	1.1	3.3	0.5	-0.8	0.1	-1.8
Locomotor activity	1.4	2.3	6.1	2.5	-0.4	1.7	0.5
Locomotor testing distance	2.1	3.5	9.6	3.1	-0.5	2.1	-0.1
Locomotor testing rearing	1.8	2.7	6.3	2.5	-0.9	1.9	-0.1
Locomotion in novel chamber	1.4	1.7	4.6	1.3	-2.1	0.7	0.2
Locomotion in novel chamber post-restriction	1.9	2.2	3.9	1.6	-2.0	1.2	1.0
Fecal boli incidents, locomotor time 1	0.8	0.9	1.5	-1.2	-0.5	-1.2	0.5
Change in fecal boli incidents, locomotor task	0.9	0.8	1.4	1.2	-0.7	0.7	-0.9
Time >=10cm from walls, locomotor time 1	1.6	1.6	6.4	-0.2	-2.5	0.1	-0.1
Bouts of movement, locomotor time 1	3.1	3.4	6.7	-1.2	2.6	-0.9	2.2
Total resting periods, locomotor time 1	2.6	2.9	5.4	-1.2	2.3	-1.1	1.9
Rest time, locomotor task time 1	1.2	1.3	1.8	1.2	-0.6	1.3	1.2
Distance moved, locomotor task time 1	0.3	0.4	0.9	-0.4	-0.3	-0.5	-1.0
Vertical activity count, locomotor time 1	1.1	1.2	1.9	1.1	-1.4	1.2	-0.3
Time >=10cm from walls, locomotor time 2	0.5	0.5	1.4	-0.7	-0.1	0.4	1.2
Bouts of movement, locomotor time 2	0.6	0.7	2.0	-0.7	1.4	-0.5	0.0
Total resting periods, locomotor time 2	0.3	0.3	0.9	-0.5	0.9	-0.4	0.1
Rest time, locomotor task time 2	2.1	2.4	4.5	1.7	-2.1	1.5	0.3
Distance moved, locomotor task time 2	0.8	0.9	1.9	-1.1	1.4	-0.6	0.6
Vertical activity count, locomotor time 2	0.6	0.7	0.9	0.7	0.8	1.0	0.8
Light reinforcement 1	0.3	0.5	0.8	0.4	0.4	0.9	0.8
Light reinforcement 2	0.5	0.6	1.3	-0.1	-1.1	1.1	0.1
Bone: marrow area	1.7	3.6	9.3	0.5	-3.0	0.6	-2.1
Bone: maximum diameter	0.6	1.1	2.6	-1.6	-0.6	-1.1	-0.6
Bone: maximum force	3.4	5.8	9.5	-3.1	0.4	-2.8	-2.4
Bone: maximum moment	2.9	5.0	8.1	-2.8	0.4	-2.6	-2.3
Mean time between licks in bursts	0.5	0.7	1.7	0.3	1.3	-0.4	-0.8
Mean num. licks in bursts	0.3	0.3	0.6	0.8	0.1	0.5	0.5
Cd content in liver	0.6	0.7	1.4	0.2	-1.2	0.7	0.9
Co content in liver	2.3	2.7	4.6	2.1	0.2	1.9	1.5
Cu content in liver	0.1	0.1	0.3	-0.5	0.4	-0.2	0.2
Fe content in liver	0.3	0.4	0.8	-0.9	-0.4	-0.8	-0.0
K content in liver	1.6	1.6	2.9	-1.2	0.1	-1.4	-1.7
Mg content in liver	0.8	0.8	2.8	-0.3	-0.5	0.0	-1.7
Mn content in liver	2.0	2.2	5.1	-2.3	1.1	-1.6	-0.3
Na content in liver	0.7	0.7	1.7	-1.3	0.6	-0.7	-0.5
Rb content in liver	1.5	1.8	2.8	1.5	-1.7	1.4	-0.4
Se content in liver	0.6	0.7	1.7	-1.3	-0.3	-0.9	0.5
Sr content in liver	3.5	3.2	5.6	-2.0	2.4	-1.8	0.2
Zn content in liver	1.4	1.5	2.1	-1.4	1.4	-1.2	-0.9
Bone: minimum diameter	1.3	2.4	5.5	0.2	-2.3	0.5	-2.0
Time in familiar zone, hab. session 1	0.2	0.2	0.3	0.4	-0.1	0.5	-0.5
Time in novel zone, hab. session 1	0.4	0.4	0.9	1.0	-0.6	0.4	0.0
Total zone transitions, hab. session 1	0.1	0.2	0.7	-0.8	0.3	-0.1	-0.1
Total locomotion distance, hab. session 1	0.6	0.9	1.8	0.5	-1.3	1.0	-0.8
Locomotion velocity, hab. session 1	0.2	0.3	0.5	0.1	-0.7	0.6	-0.5
Time in familiar zone, hab. session 2	0.3	0.3	0.7	0.8	0.6	-0.1	0.1
Time in novel zone, hab. session 2	0.2	0.2	0.5	-0.7	-0.3	-0.0	-0.6
Total zone transitions, hab. session 2	0.9	1.1	2.6	-1.0	0.1	-0.9	-1.6
Total locomotion distance, hab. session 2	0.7	0.9	2.5	0.3	-0.9	0.3	-1.6
Locomotion velocity, hab. session 2	0.7	0.9	2.0	0.3	-1.2	0.3	-1.4
Novel to familiar place preference ratio	1.9	2.0	4.3	-2.1	0.6	-1.8	-0.1
Novelty place preference	1.1	1.1	2.7	-1.7	0.4	-1.3	0.1
Time in novel zone, NPP test	0.9	0.9	2.1	-1.5	0.3	-1.1	-0.2
Total zone transitions, NPP test	1.1	1.6	2.9	-1.7	0.7	-1.5	-0.8
Total locomotion distance, NPP test	0.3	0.4	1.2	0.1	-0.7	0.2	-1.1
Locomotion velocity, NPP test	0.1	0.2	0.4	-0.0	-0.5	0.1	-0.6
Intraocular pressure	0.8	1.2	4.6	0.1	0.1	0.1	2.1
Delta distance traveled before/after self-admin	0.1	0.2	0.5	0.7	-0.0	0.1	0.3
Delta ambulatory time before/after self-admin	0.2	0.3	0.7	0.8	-0.2	0.5	0.3
Parametrial fat weight	1.5	2.9	8.0	1.3	-2.8	0.1	-1.4
Pavlov. Cond. lever latency	0.5	0.6	1.4	0.9	-0.5	0.5	1.2
Pavlov. Cond. magazine entry latency	0.6	0.7	1.4	-1.0	0.3	-0.6	-1.2
Pavlov. Cond. change in total contacts	0.3	0.3	1.0	-1.0	-0.1	-0.3	-0.0
Pavlov. Cond. index score	0.3	0.3	0.7	-0.9	0.6	-0.5	-0.2
Pavlov. Cond. latency score	0.2	0.2	0.4	-0.6	0.4	-0.3	-0.5
Pavlov. Cond. lever contacts	0.1	0.2	0.6	-0.2	0.1	-0.1	-0.8
Pavlov. Cond. magazine entry number	0.5	0.6	1.3	1.2	-0.8	0.6	-0.4
Pavlov. Cond. intertrial magazine entries	0.6	0.8	2.4	0.5	0.2	0.6	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.2	-1.1	0.7	-0.7	-0.3
Pavlov. Cond. response bias	0.2	0.3	0.6	-0.8	0.7	-0.2	-0.2
Pavlov. Cond. lever latency	0.9	1.2	2.3	1.4	-0.3	1.5	0.5
Pavlov. Cond. magazine entry latency	3.2	3.7	6.2	-2.3	1.8	-2.5	-0.4
Pavlov. Cond. change in total contacts	2.1	2.9	6.8	-2.6	0.8	-2.1	0.1
Pavlov. Cond. index score	2.7	3.4	6.3	-2.5	1.1	-2.4	-0.4
Pavlov. Cond. latency score	2.3	2.8	5.3	-2.3	0.9	-2.2	-0.5
Pavlov. Cond. lever contacts	0.8	1.1	2.1	-1.4	0.6	-1.4	0.3
Pavlov. Cond. magazine entry number	5.1	6.3	11.0	3.3	-2.2	3.0	0.5
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.7	1.1	-1.1	1.3	0.9
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.8	6.9	-2.6	1.3	-2.5	-0.3
Pavlov. Cond. response bias	2.1	2.8	5.0	-2.2	1.2	-2.2	0.0
Time in closed arm before self-admin	0.4	0.5	0.8	-0.9	-0.5	-0.9	0.2
Time in closed arm after self-admin	0.6	0.7	1.1	0.8	-0.6	1.1	-0.7
Time in open arm before self-admin	1.5	1.6	4.3	2.1	0.2	1.4	-0.3
Time in open arm after self-admin	0.5	0.6	1.4	0.4	0.9	0.1	1.2
Bone: periosteal estimation	0.8	1.6	2.8	-0.9	-1.5	-0.6	-1.7
Bone: periosteal perimeter	0.5	0.9	1.2	-1.1	-1.0	-0.6	-1.0
Bone: post-yield work	2.7	3.6	5.5	-1.9	-2.3	-1.4	-1.9
Progressive ratio test 1 active lever presses	1.8	1.9	3.6	1.5	-1.9	1.1	0.6
Progressive ratio test 1 breakpoint	1.6	1.7	3.2	1.4	-1.8	1.0	0.7
Progressive ratio test 1 inactive lever presses	0.4	0.5	1.4	1.2	-0.3	0.4	-0.5
Progressive ratio test 2 active lever presses	1.7	1.9	4.9	1.3	-2.2	0.9	0.2
Progressive ratio test 2 breakpoint	2.5	2.8	5.0	1.8	-2.2	1.6	0.6
Progressive ratio test 2 inactive lever presses	2.4	2.8	5.7	1.9	-2.4	1.3	0.0
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.0	-0.5	-0.1	-0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	0.1	-0.6	0.1	-0.3
Sum of active levers in priming session hrs 5-6	2.6	2.5	4.7	-2.2	1.5	-1.1	1.4
Progressive ratio	1.5	1.8	3.4	-1.8	0.2	-1.7	-1.0
Food seeking constrained by brief footshock	0.0	0.1	0.1	0.3	0.2	-0.2	-0.3
Seeking ratio, punishment vs. effort	1.6	2.0	5.0	2.2	-0.2	1.6	0.4
Retroperitoneal fat weight	2.8	9.0	17.6	3.5	-4.2	2.4	-0.6
Reaction time number correct	0.3	0.4	1.4	-0.4	1.2	-0.4	-0.0
Reaction time mean minus median	2.4	3.2	7.1	-2.7	0.9	-2.1	0.5
Reaction time mean minus median AUC	1.4	1.8	3.2	-1.8	1.0	-1.5	0.9
Reaction time num false alarms	0.9	1.2	3.3	1.8	0.3	1.3	0.0
Reaction time num false alarms AUC	0.5	0.7	1.3	1.2	0.9	0.7	-0.1
Reaction time trials correct on left	0.3	0.4	1.4	-0.4	1.2	-0.4	-0.0
Reaction time trials on left	0.4	0.5	1.6	-0.5	1.3	-0.4	0.0
Reaction time mean	0.2	0.3	0.7	-0.7	-0.3	-0.0	0.9
Reaction time mean AUC	0.3	0.3	0.7	-0.7	-0.4	-0.0	0.9
Median of all reaction times	0.1	0.2	0.3	-0.2	-0.5	0.3	0.5
Reaction time omissions	0.7	1.0	1.7	-0.9	1.0	-1.3	0.6
Reaction time false alarm rate	0.6	0.8	2.2	1.5	-0.1	1.0	-0.2
Reaction time premature initiation rate	1.6	2.2	4.8	-0.8	2.2	-0.5	-1.7
Reaction time premature initiations	2.4	3.3	9.5	-1.3	3.1	-0.8	-1.2
Std. dev. reaction times	0.7	1.0	2.0	-1.4	0.3	-0.7	1.1
Reaction time trials completed	0.4	0.5	1.6	-0.5	1.3	-0.4	0.0
Reaction time trials AUC	0.2	0.3	1.1	-0.3	1.0	-0.2	-0.1
Run reversals in cocaine runway, females	1.6	1.5	5.7	0.3	0.2	-0.5	-2.4
Run reversals in cocaine runway, males	0.2	0.2	0.3	0.5	-0.4	0.4	0.4
Latency to leave start box in cocaine runway	0.5	0.6	1.4	0.0	-1.2	0.7	-0.7
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.3	-0.2	0.4	-0.1
Latency to leave start box in cocaine runway, M	0.8	0.8	2.7	0.4	-1.6	0.4	-0.4
Std. dev. time between licks in bursts	0.5	0.6	1.7	1.3	0.3	0.5	-0.5
Total sessions with >9 infusions	2.2	2.4	5.4	1.6	-2.3	0.9	-0.9
Short access day 1 total inactive lever presses	2.7	3.0	5.0	2.2	-2.0	1.8	-0.3
Short access day 10 total inactive lever presses	3.3	3.7	6.7	2.6	-1.4	2.5	0.0
Short access day 1 total infusions	2.2	2.4	4.8	1.8	-2.2	1.0	-0.8
Short access day 10 total infusions	2.1	2.3	5.8	1.0	-2.4	0.3	-1.5
Short access total infusions	1.7	1.9	4.3	1.3	-2.1	0.5	-1.2
Short access day 1 locomotion	1.7	1.9	3.1	1.4	-1.5	0.3	-1.8
Short access day 10 total locomotion	1.1	1.2	1.8	1.0	-1.3	0.5	-1.3
Short access total locomotion	1.6	1.6	3.4	1.1	-1.3	0.6	-1.8
One hour access (0.3 mA shock)	4.0	4.7	8.9	2.5	-3.0	1.9	0.2
Compulsive drug intake	1.7	1.7	6.7	-0.4	2.6	-0.5	0.0
One hour access (shock baseline)	3.7	4.2	11.8	1.7	-3.4	1.1	1.0
Social response proportion	1.0	1.1	2.3	-1.2	0.7	-1.5	0.0
Social responses	0.6	0.8	1.4	-0.4	1.2	-0.9	0.8
Social time	0.1	0.2	0.4	-0.3	0.6	-0.2	0.4
Soleus weight	2.5	7.4	12.4	3.5	-2.8	2.9	0.8
Bone: stiffness	2.1	3.4	7.4	-2.7	0.3	-2.2	-1.0
Tibialis anterior weight	6.9	23.5	37.0	-6.1	5.1	-5.3	-1.4
Time to tail flick, vehicle, before self-admin	1.4	1.5	3.0	-1.2	-0.5	-1.0	-1.7
Time to tail flick, vehicle, after self-admin	2.0	2.2	4.0	-1.0	0.4	-2.0	-1.9
Time to tail flick, test, before self-admin	1.9	1.9	4.5	1.0	-1.1	1.0	-2.1
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.2	0.1	-0.3	0.3
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.7	-0.2	0.4	-0.8	-0.3
Delta time to tail flick, test, before/after SA	2.6	2.3	4.4	-1.2	1.6	-0.9	2.1
Tibia length	1.6	4.4	9.6	-3.1	1.1	-2.6	0.3
Ambulatory time before self-admin	1.2	1.2	2.3	-1.5	0.6	-1.5	0.2
Ambulatory time after self-admin	0.1	0.1	0.2	-0.4	-0.3	0.1	0.1
Bone: tissue strength	0.2	0.2	0.6	-0.3	-0.1	-0.4	0.8
Total heroin consumption	3.5	4.1	6.1	-2.5	2.3	-2.1	0.5
Bone: trabecular number	1.1	1.8	3.0	-1.6	-0.1	-1.7	-1.2
Bone: trabecular spacing	0.8	1.0	1.8	1.3	0.3	1.2	0.8
Bone: trabecular thickness	0.4	0.5	1.4	0.4	-1.2	0.7	-0.1
Bone: trabecular tissue density	2.5	3.5	4.2	2.1	-1.6	2.0	1.8
Water consumed over 24 hours	0.9	1.0	3.2	-0.7	1.8	-0.3	0.5
Number of responses in last shaping day	0.8	0.9	2.1	1.4	0.1	1.2	-0.1