Fkbp2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	intron excision ratio	chr1_213598266_213599054	0.1	0.06	2.0e-03	0.02	0.01	0.02	0.01	2.2e-02	5.0e-02	2.6e-02	1.1e-01
2	PL	intron excision ratio	chr1_213598302_213598436	0.05	0.04	1.6e-03	0.02	0.01	0.02	0.02	1.8e-03	1.3e-02	4.4e-03	6.7e-03
3	PL	mRNA stability	Fkbp2	0.04	0.03	6.5e-03	0.02	0	0	0.01	6.7e-03	8.7e-02	1.6e-01	5.7e-02
4	Liver	intron excision ratio	chr1_213597525_213597643	0.04	0.03	5.5e-03	-0	0	0	0	4.5e-01	1.9e-01	7.9e-02	1.7e-01
5	LHb	intron excision ratio	chr1_213597525_213597643	0.3	0.16	7.0e-03	0.11	0.1	0.1	0.1	1.7e-03	3.0e-03	1.9e-03	2.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.5	0.8	2.0	-0.9	0.8	-0.8	-0.3	1.4
Area under the delay curve	0.3	0.3	0.7	0.1	0.7	-0.5	-0.4	0.9
BMI with tail	1.9	6.4	17.1	-2.4	1.9	-1.9	-1.5	4.1
BMI without tail	0.4	1.2	3.2	-1.5	0.3	-0.6	0.1	1.8
Body weight	1.0	4.5	13.8	-3.7	0.1	-0.0	0.4	2.9
Weight adjusted by age	0.8	1.2	2.3	-1.5	-1.1	1.3	0.8	0.4
Bone surface	1.4	2.5	9.7	-3.1	0.1	0.3	0.4	1.6
Bone volume	0.7	1.2	3.1	-1.8	0.8	-0.4	-0.4	1.4
Breakpoint value in progressive ratio session	1.5	1.7	4.1	-2.0	-1.3	1.3	1.1	0.2
Number of licking bursts	0.2	0.3	0.4	-0.6	-0.4	0.6	0.6	0.1
Context. condit. distance diff. score	1.3	1.5	2.7	1.6	1.1	-1.4	-1.3	0.5
Locomotion velocity, session 1	0.1	0.2	0.6	-0.2	0.3	-0.2	0.0	0.8
Locomotion distance, session 1	0.8	1.0	3.3	-0.8	0.8	-0.5	-0.5	1.8
Locomotion velocity, session 2	1.0	1.2	3.5	-1.9	-0.4	0.6	0.2	1.4
Locomotion distance, session 2	0.3	0.5	1.1	-1.0	0.1	0.3	0.3	1.1
Locomotion velocity, session 3	3.3	3.8	6.0	0.5	2.2	-2.0	-1.9	2.5
Locomotion distance, session 3	0.4	0.4	0.9	0.2	0.5	-0.5	-0.7	1.0
Stereotopy head waving bouts, day 3	2.7	3.1	5.8	0.8	2.0	-2.4	-1.5	1.7
Stereotopy head waving duration, day 3	1.1	1.3	2.3	0.8	1.4	-1.5	-1.1	0.6
Locomotion velocity, session 7	1.7	1.8	2.5	0.7	1.6	-1.5	-1.5	1.4
Locomotion distance, session 7	0.3	0.4	0.7	0.2	0.6	-0.7	-0.4	0.9
Stereotopy head waving bouts, day 7	0.3	0.4	0.8	0.1	0.9	-0.5	-0.8	0.5
Stereotopy head waving duration, day 7	0.3	0.3	1.0	-1.0	0.1	0.3	-0.2	0.7
Locomotion velocity, session 8	0.4	0.5	1.1	-1.1	-0.6	0.3	0.9	0.4
Locomotion distance, session 8	1.1	1.7	2.7	0.5	1.6	-1.3	-1.2	1.4
Degree of sensitization distance	0.5	0.5	0.8	0.0	0.9	-0.9	-0.5	0.9
Degree of sensitization stereotypy	0.2	0.2	0.5	-0.7	0.3	0.3	-0.3	0.5
Conditioned locomotion	1.1	1.3	3.5	-1.4	-0.6	0.6	1.9	0.5
Cocaine response after cond. corrected	1.0	1.2	2.0	1.4	1.1	-1.4	-0.8	0.4
Cocaine response after cond. not corrected	0.9	1.0	1.8	1.2	1.0	-1.3	-0.8	0.4
Cocaine response before conditioning	0.4	0.5	0.9	-0.9	-0.8	0.9	0.5	-0.2
Saline control response	2.2	2.9	6.1	-2.5	-2.0	1.4	1.4	0.6
Bone: connectivity density	0.8	1.3	4.1	-2.0	0.0	0.1	0.2	1.5
Bone: cortical apparent density	0.7	1.0	1.9	-0.3	-1.4	1.1	0.9	-0.8
Bone: cortical area	0.4	0.6	1.5	-1.1	-0.2	0.3	-0.3	1.2
Bone: cortical porosity	0.2	0.2	0.4	-0.5	-0.5	0.3	0.6	-0.3
Bone: cortical porosity	0.4	0.4	0.8	-0.9	-0.6	0.4	0.8	0.0
Bone: cortical thickness	2.7	4.5	7.8	-2.3	-2.8	2.2	2.1	0.1
Bone: cortical thickness	0.6	0.7	1.3	-0.7	-1.1	0.6	1.1	-0.1
Bone: cortical tissue density	0.9	1.2	2.3	-0.5	-1.5	1.3	1.1	-0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.4	-0.3	0.2	0.0	-0.0
Condit. Reinf. active-inactive response ratio	0.4	0.4	0.9	-0.2	-0.7	0.6	0.5	-0.9
Condit. Reinf. active responses	0.2	0.2	0.4	-0.1	0.4	-0.3	-0.6	0.6
Condit. Reinf. inactive responses	1.0	1.3	1.8	0.4	1.3	-1.1	-1.2	1.4
Incentive salience index mean	0.2	0.2	0.6	-0.6	0.0	-0.2	-0.4	0.8
Condit. Reinf. lever presses	0.4	0.5	1.4	-0.7	0.4	-0.5	-0.5	1.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	0.3	0.7	-0.3	-0.0	-0.2
Condit. Reinf. active-inactive response ratio	1.4	1.7	4.4	0.9	2.1	-1.3	-1.2	-0.0
Condit. Reinf. active responses	0.1	0.1	0.2	-0.3	-0.1	0.3	0.4	0.0
Condit. Reinf. inactive responses	0.9	1.2	2.6	-0.8	-1.6	1.0	1.2	0.1
Condit. Reinf. lever presses	0.6	0.8	2.6	-1.6	-0.3	0.7	0.3	0.9
Condit. Reinf. lever reinforcers received	0.2	0.3	0.4	-0.6	-0.4	0.7	0.6	-0.0
Conditioned reinforcement - actives	0.0	0.1	0.2	-0.1	0.4	0.1	-0.5	-0.2
Conditioned reinforcement - inactives	2.3	3.4	9.2	2.0	1.5	-1.0	-3.0	0.6
Conditioned locomotion	3.5	4.6	11.0	3.3	2.0	-1.7	-2.3	-0.1
Patch foraging indifference point 0 sec	0.1	0.1	0.4	0.0	-0.1	0.0	-0.7	-0.0
Patch foraging indifference point AUC	1.1	1.6	3.1	-1.8	-1.3	1.6	0.9	0.0
Delay disc. indifference point, 0s delay	1.2	1.3	2.5	0.4	1.2	-1.6	-0.8	1.3
Delay disc. indifference point, 16s delay	0.8	0.8	1.8	0.9	0.8	-0.6	-1.3	0.7
Delay disc. indifference point, 2s delay	0.7	0.8	1.6	0.3	1.3	-0.8	-0.8	0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.2	-0.4	0.2	-0.1	0.4
Delay disc. indifference point, 4s delay	0.3	0.3	0.7	0.2	0.4	-0.7	-0.3	0.8
Delay disc. indifference point, 8s delay	0.1	0.1	0.1	0.0	0.3	-0.3	0.3	0.2
Indifference point function ln k	3.3	5.7	12.4	3.5	1.9	-2.8	-2.2	-0.2
Indifference point function log k	3.3	5.7	12.4	3.5	1.9	-2.8	-2.2	-0.2
Patch foraging total patch changes 0 sec	0.1	0.1	0.4	-0.1	-0.6	0.3	-0.4	-0.2
Patch foraging total patch changes 12 sec	2.4	3.1	6.4	-2.5	-1.9	1.9	0.8	1.1
Patch foraging total patch changes 18 sec	0.3	0.4	0.8	-0.9	-0.8	0.5	0.0	-0.5
Patch foraging total patch changes 24 sec	1.2	2.0	3.3	-1.8	-1.5	1.6	-0.2	1.4
Patch foraging total patch changes 6 sec	0.4	0.6	1.7	-1.3	-0.7	0.6	-0.1	0.8
Patch foraging time to switch 0 sec	0.6	1.3	3.0	-1.6	0.9	-0.2	0.3	1.7
Patch foraging water rate 0 sec	1.2	2.6	7.9	2.8	-0.2	-0.6	-1.7	-1.3
Patch foraging water rate 12 sec	2.2	4.6	14.2	3.8	0.6	-1.3	-2.2	-1.4
Patch foraging water rate 18 sec	1.2	1.9	4.2	2.1	0.5	-1.4	-1.8	0.0
Patch foraging water rate 24 sec	1.7	2.4	6.7	2.6	0.6	-1.3	-1.4	-1.0
Patch foraging water rate 6 sec	1.9	2.8	8.3	2.9	0.3	-1.2	-1.9	-0.9
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.6	0.5	0.3	-0.1	-0.8	0.7
Distance traveled before self-admin	0.5	0.6	1.9	-1.0	0.3	0.4	-0.4	1.4
Distance traveled after self-admin	0.6	0.7	1.8	-0.6	-0.9	1.3	0.6	-0.3
Extensor digitorum longus weight	3.0	11.9	34.8	-5.9	-2.5	2.4	2.4	2.7
Bone: elastic displacement	0.4	0.5	1.0	1.0	-0.6	0.0	0.6	-0.8
Bone: elastic work	0.8	1.1	2.0	-1.1	-1.4	0.6	1.1	0.9
Bone: endosteal estimation	2.9	6.3	10.8	1.2	3.3	-3.0	-2.6	1.8
Bone: endosteal perimeter	3.6	7.7	14.0	1.4	3.7	-3.1	-3.1	1.7
Epididymis fat weight	3.1	10.5	15.9	3.5	3.6	-3.3	-4.0	0.8
Delta time in closed arm before/after self-admin	0.3	0.3	0.8	-0.4	-0.5	-0.3	0.3	0.9
Delta time in open arm before/after self-admin	0.4	0.4	1.3	-0.5	-0.4	1.1	-0.4	0.1
Diff in mean of infusions in LGA sessions	0.4	0.4	0.9	-0.8	-0.9	0.5	0.4	0.6
Delay discount exponential model param	0.2	0.2	0.5	0.0	-0.5	0.3	0.2	-0.7
Extinction: sum of active levers before priming	0.9	1.0	3.1	-1.8	-0.4	0.8	0.5	1.0
Active lever presses in extinction session 6	1.5	1.5	4.0	-2.0	-0.7	1.3	0.7	0.8
Bone: final force	1.1	1.7	4.8	-2.2	-0.2	0.4	-0.1	1.9
Bone: final moment	1.1	1.7	4.5	-2.1	-0.2	0.3	-0.2	2.0
Food consumed during 24 hour testing period	0.3	0.4	0.9	-0.2	-0.6	1.0	-0.1	-0.9
Glucose	3.8	5.9	9.0	2.1	2.7	-2.6	-3.0	1.4
Heart weight	2.7	4.1	7.8	1.2	2.3	-2.8	-1.8	1.7
Delay discount hyperbolic model param	0.2	0.3	0.6	0.0	-0.7	0.4	0.3	-0.8
Intermittent access intake day 1-15 change	0.4	0.7	1.9	1.4	0.2	-0.4	-0.8	-1.0
Intermittent access intake escalation	0.3	0.7	1.5	1.2	0.2	-0.3	-0.7	-1.1
Intermittent access intake escalation 2	0.5	0.6	1.3	1.1	0.4	-0.2	-1.1	-0.5
Intermitt. access day 1 inactive lever presses	0.1	0.3	1.0	0.4	-0.0	0.2	-0.3	-1.0
Intermitt. access day 15 inactive lever presses	2.2	4.5	11.4	1.6	2.2	-1.4	-3.4	1.3
Intermitt. access escalation Index	0.9	1.2	4.1	2.0	0.5	-1.0	-0.9	-0.3
Intermittent access day 1 total infusions	5.5	8.8	13.3	1.9	3.6	-3.5	-3.0	2.4
Intermittent access day 15 total infusions	4.7	7.0	9.5	2.8	3.1	-3.0	-2.9	0.7
Intermittent access terminal intake (last 3 days)	6.9	9.1	12.5	2.5	3.5	-3.3	-3.5	1.8
Intermittent access total infusions	7.1	8.3	11.9	2.2	3.4	-3.4	-3.1	1.9
Intermittent access day 1 locomotion	4.1	5.2	7.5	1.7	2.7	-2.6	-2.4	1.9
Intermittent access day 15 total locomotion	3.6	6.5	10.7	2.5	2.8	-2.6	-3.3	1.1
Intermittent access total locomotion	10.4	12.4	18.2	2.9	4.1	-3.7	-4.3	2.2
Intermittent access standard deviation	0.6	1.2	2.1	1.4	0.8	-0.9	-1.5	-0.0
Left kidney weight	0.7	3.2	5.6	1.6	2.4	-2.0	-1.8	0.6
Right kidney weight	0.4	1.6	2.7	1.2	1.6	-1.3	-1.5	0.4
Cocaine induced anxiety	0.1	0.1	0.3	-0.2	0.4	0.3	0.2	-0.5
Post-drug Anxiety	0.2	0.2	0.8	-0.9	0.0	0.5	0.4	0.0
Baseline Anxiety	0.4	0.5	1.1	-0.6	-1.1	0.5	0.4	0.7
Tail length	0.8	3.3	5.4	-1.4	-2.3	2.0	2.0	-1.0
Length with tail	1.1	4.8	9.6	-3.1	-2.2	2.0	2.3	-0.0
Length without tail	0.9	2.9	7.4	-2.7	-1.6	1.4	1.4	0.7
Times rat made contact with spout	1.2	1.3	2.1	-0.8	-1.4	1.0	1.5	-1.0
Lifetime Intake	5.0	6.1	9.8	1.9	2.9	-3.1	-2.4	1.7
Liver weight, left	0.7	1.1	2.0	1.3	1.1	-1.4	-0.8	-0.0
Liver weight, right	1.9	3.3	4.8	2.0	1.6	-2.2	-1.9	1.2
Locomotor activity	0.9	1.4	4.1	2.0	-0.2	-0.9	-0.5	-1.3
Locomotor testing distance	0.9	1.6	4.9	2.2	0.0	-1.2	-1.1	-0.9
Locomotor testing rearing	0.7	1.3	3.8	2.0	0.6	-1.1	-1.0	-0.4
Locomotion in novel chamber	3.6	4.5	7.0	2.6	2.2	-2.1	-2.5	0.3
Locomotion in novel chamber post-restriction	1.4	2.3	4.7	2.2	1.6	-1.3	-1.2	-1.0
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	-0.2	0.5	0.2	-0.5	-0.2
Change in fecal boli incidents, locomotor task	0.4	0.4	1.4	0.1	0.3	-1.2	0.4	0.4
Time >=10cm from walls, locomotor time 1	2.7	2.9	7.0	0.7	2.6	-1.9	-1.7	0.8
Bouts of movement, locomotor time 1	5.6	6.3	9.7	-1.4	-3.1	3.1	2.3	-2.4
Total resting periods, locomotor time 1	4.3	4.8	7.6	-1.1	-2.7	2.8	1.8	-2.2
Rest time, locomotor task time 1	0.7	0.9	2.2	1.4	0.5	-0.3	-0.2	-1.5
Distance moved, locomotor task time 1	0.5	0.7	2.3	-0.3	0.6	-0.5	-0.7	1.5
Vertical activity count, locomotor time 1	0.4	1.1	1.4	1.2	1.2	-1.1	-1.0	0.5
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.4	-0.4	0.1	0.7	0.2	-0.6
Bouts of movement, locomotor time 2	0.3	0.5	1.1	-0.7	-1.0	1.0	0.2	-0.1
Total resting periods, locomotor time 2	0.1	0.2	0.3	-0.4	-0.5	0.6	0.1	-0.3
Rest time, locomotor task time 2	1.8	2.2	4.5	1.7	1.6	-2.1	-1.0	-0.4
Distance moved, locomotor task time 2	1.4	1.7	3.0	-1.3	-1.3	1.7	1.3	-0.4
Vertical activity count, locomotor time 2	0.5	0.6	1.1	0.1	-1.0	0.8	1.0	-0.8
Light reinforcement 1	0.2	0.4	1.1	0.2	-0.7	0.6	0.1	-1.1
Light reinforcement 2	1.0	1.6	5.1	0.9	1.3	-0.4	-2.3	0.4
Bone: marrow area	2.9	6.3	11.0	1.3	3.3	-3.1	-2.5	1.8
Bone: maximum diameter	0.4	0.7	1.1	-0.6	1.0	-0.5	-0.9	0.9
Bone: maximum force	1.8	3.2	8.7	-2.5	0.7	-0.2	-0.7	2.9
Bone: maximum moment	1.8	3.2	9.2	-2.4	0.6	-0.3	-0.8	3.0
Mean time between licks in bursts	0.3	0.7	1.5	-0.5	-1.2	0.4	1.0	0.6
Mean num. licks in bursts	0.2	0.2	0.8	0.5	-0.4	-0.1	0.2	-0.9
Cd content in liver	0.9	1.0	1.6	1.2	1.3	-0.7	-1.1	-0.5
Co content in liver	1.4	1.7	4.1	1.2	-1.1	0.5	1.1	-2.0
Cu content in liver	0.2	0.2	0.9	0.1	-0.1	0.3	0.4	-0.9
Fe content in liver	0.1	0.1	0.2	-0.4	0.4	-0.1	-0.2	0.1
K content in liver	0.3	0.2	0.4	-0.6	0.1	-0.5	0.4	0.6
Mg content in liver	0.5	0.5	0.9	0.7	0.6	-0.9	-0.6	0.7
Mn content in liver	1.3	1.4	3.9	-2.0	-0.9	1.0	-0.1	1.3
Na content in liver	0.2	0.3	0.6	-0.8	-0.5	0.4	0.1	0.4
Rb content in liver	1.2	1.4	2.9	1.7	1.1	-1.4	-0.4	-0.5
Se content in liver	0.3	0.4	1.1	0.4	0.7	0.1	-1.1	-0.3
Sr content in liver	2.1	1.8	3.0	-1.7	-1.5	1.7	1.1	0.0
Zn content in liver	0.4	0.5	0.9	-0.7	-0.6	1.0	0.6	-0.0
Bone: minimum diameter	2.9	5.3	7.5	1.1	2.7	-2.5	-2.6	2.2
Time in familiar zone, hab. session 1	0.4	0.4	0.9	0.6	0.3	-0.9	-0.5	0.5
Time in novel zone, hab. session 1	0.0	0.0	0.1	0.4	0.1	0.0	0.0	-0.0
Total zone transitions, hab. session 1	0.3	0.4	1.0	-1.0	-0.2	0.7	0.6	0.0
Total locomotion distance, hab. session 1	0.7	1.0	2.0	0.6	1.4	-1.0	-1.0	0.8
Locomotion velocity, hab. session 1	0.1	0.2	0.6	0.1	0.8	-0.3	-0.4	0.4
Time in familiar zone, hab. session 2	0.4	0.4	1.0	0.1	-1.0	-0.0	1.0	-0.4
Time in novel zone, hab. session 2	0.5	0.5	1.0	-0.3	0.7	0.0	-1.0	0.9
Total zone transitions, hab. session 2	0.8	1.1	3.2	-1.4	0.3	-0.1	0.1	1.8
Total locomotion distance, hab. session 2	0.8	1.0	2.0	-0.0	1.1	-1.2	-0.7	1.4
Locomotion velocity, hab. session 2	0.9	1.3	1.9	0.2	1.3	-1.4	-0.9	1.3
Novel to familiar place preference ratio	0.3	0.4	1.4	-1.2	-0.1	0.7	0.0	0.2
Novelty place preference	0.2	0.2	0.6	-0.8	0.1	0.5	-0.3	0.1
Time in novel zone, NPP test	0.1	0.1	0.4	-0.6	0.2	0.4	-0.4	0.2
Total zone transitions, NPP test	0.8	1.2	3.9	-2.0	-0.2	0.8	0.7	0.9
Total locomotion distance, NPP test	0.3	0.4	0.8	-0.3	0.9	-0.6	-0.3	0.9
Locomotion velocity, NPP test	0.1	0.1	0.3	-0.4	0.6	-0.2	0.0	0.4
Intraocular pressure	0.8	1.2	3.8	1.3	-0.3	0.5	-0.4	-2.0
Delta distance traveled before/after self-admin	0.6	0.7	1.2	0.5	-1.1	0.6	0.7	-1.1
Delta ambulatory time before/after self-admin	0.5	0.6	1.2	0.2	-0.8	0.7	0.8	-1.1
Parametrial fat weight	3.4	8.0	11.9	3.0	3.5	-2.8	-3.3	0.6
Pavlov. Cond. lever latency	0.3	0.3	1.3	0.5	0.2	0.1	0.3	-1.1
Pavlov. Cond. magazine entry latency	0.3	0.3	1.0	-0.6	0.2	-0.2	-0.4	1.0
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	-0.3	0.3	0.2	-0.7	0.6
Pavlov. Cond. index score	0.1	0.2	0.3	-0.5	-0.5	0.4	-0.0	0.5
Pavlov. Cond. latency score	0.1	0.1	0.5	-0.4	-0.3	0.1	-0.2	0.7
Pavlov. Cond. lever contacts	0.3	0.3	1.3	-0.2	0.0	-0.3	-0.4	1.2
Pavlov. Cond. magazine entry number	0.3	0.4	0.7	0.7	0.7	-0.9	-0.3	0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.6	0.9	-0.3	0.6	-0.2	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.5	-0.7	-0.5	0.4	-0.0	0.7
Pavlov. Cond. response bias	0.1	0.2	0.3	-0.5	-0.5	0.5	0.0	0.3
Pavlov. Cond. lever latency	0.3	0.4	0.8	0.9	0.1	-0.4	0.4	-0.9
Pavlov. Cond. magazine entry latency	2.0	2.5	6.3	-2.5	-1.3	1.6	1.0	0.9
Pavlov. Cond. change in total contacts	0.6	1.0	2.5	-1.6	-0.1	1.2	-0.1	1.1
Pavlov. Cond. index score	1.0	1.3	3.8	-2.0	-0.5	1.1	0.1	1.1
Pavlov. Cond. latency score	0.8	1.1	3.2	-1.8	-0.2	0.9	-0.1	1.1
Pavlov. Cond. lever contacts	0.2	0.3	0.9	-0.9	-0.3	0.5	-0.1	0.6
Pavlov. Cond. magazine entry number	3.3	4.0	10.4	3.2	1.5	-2.2	-0.9	-1.4
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.7	1.3	0.6	-0.8	0.0	-1.2
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.6	4.6	-2.1	-0.7	1.3	0.2	1.2
Pavlov. Cond. response bias	0.9	1.2	3.3	-1.8	-0.7	1.0	0.2	1.2
Time in closed arm before self-admin	0.5	0.6	1.2	0.6	1.0	-0.5	-1.1	0.4
Time in closed arm after self-admin	0.4	0.4	0.7	0.6	0.5	-0.9	-0.6	0.3
Time in open arm before self-admin	0.5	0.5	1.3	0.4	-0.8	-0.5	1.1	-0.4
Time in open arm after self-admin	0.5	0.6	1.2	-0.3	-1.1	0.9	0.7	-0.4
Bone: periosteal estimation	1.4	2.9	4.1	-0.0	2.0	-1.8	-1.9	1.9
Bone: periosteal perimeter	0.8	1.4	2.2	-0.4	1.4	-1.1	-1.3	1.5
Bone: post-yield work	3.7	5.4	9.1	-0.8	2.9	-2.2	-2.1	3.0
Progressive ratio test 1 active lever presses	0.5	0.6	1.3	0.6	1.2	-1.0	-0.4	0.5
Progressive ratio test 1 breakpoint	0.5	0.6	1.3	0.5	1.1	-0.9	-0.4	0.5
Progressive ratio test 1 inactive lever presses	0.3	0.4	1.3	0.3	-0.1	0.1	-1.1	0.8
Progressive ratio test 2 active lever presses	3.0	3.5	5.9	1.8	2.0	-1.8	-2.4	0.9
Progressive ratio test 2 breakpoint	3.0	3.5	6.0	1.8	2.0	-1.8	-2.4	1.0
Progressive ratio test 2 inactive lever presses	5.0	8.1	15.8	3.3	2.7	-2.5	-4.0	0.7
Incentive Sensitization - Responses	1.5	2.2	6.0	0.2	1.1	-0.9	-2.4	1.6
Incentive Sensitization - Breakpoint	1.9	2.4	6.8	0.4	1.2	-1.0	-2.6	1.6
Sum of active levers in priming session hrs 5-6	1.7	1.6	3.7	-1.1	-1.3	1.9	0.8	-0.8
Progressive ratio	0.9	1.5	4.3	-1.2	0.9	-0.4	-0.8	2.1
Food seeking constrained by brief footshock	0.0	0.0	0.1	-0.2	-0.2	0.1	0.1	0.2
Seeking ratio, punishment vs. effort	0.6	0.9	2.1	1.5	-0.7	-0.2	0.3	-1.3
Retroperitoneal fat weight	5.8	24.7	45.2	6.7	4.9	-5.4	-5.0	-0.2
Reaction time number correct	0.2	0.4	1.1	-0.6	-1.0	0.4	0.5	-0.1
Reaction time mean minus median	0.8	2.1	5.8	-2.4	-0.8	1.0	1.8	0.3
Reaction time mean minus median AUC	0.7	1.8	3.7	-1.7	-1.1	0.9	1.9	-0.2
Reaction time num false alarms	0.3	0.4	0.6	0.7	-0.8	-0.3	0.3	-0.7
Reaction time num false alarms AUC	0.3	0.5	1.5	0.1	-1.2	0.1	0.8	-0.6
Reaction time trials correct on left	0.2	0.4	1.1	-0.6	-1.0	0.4	0.5	-0.1
Reaction time trials on left	0.3	0.5	1.3	-0.7	-1.1	0.5	0.6	-0.2
Reaction time mean	0.1	0.1	0.5	-0.3	0.2	0.2	0.7	0.0
Reaction time mean AUC	0.1	0.1	0.5	-0.2	0.3	0.1	0.7	0.0
Median of all reaction times	0.1	0.1	0.4	0.3	0.6	-0.2	0.1	0.2
Reaction time omissions	1.4	2.1	4.9	-1.7	-1.3	1.0	2.2	-0.2
Reaction time false alarm rate	0.1	0.1	0.4	0.6	-0.2	-0.5	0.0	-0.2
Reaction time premature initiation rate	1.4	2.0	3.9	-2.0	-1.7	1.1	0.4	1.2
Reaction time premature initiations	2.1	3.7	7.3	-2.5	-2.7	1.8	1.1	0.7
Std. dev. reaction times	0.6	1.1	2.8	-1.3	-0.5	0.7	1.7	-0.4
Reaction time trials completed	0.3	0.5	1.3	-0.7	-1.1	0.5	0.6	-0.2
Reaction time trials AUC	0.1	0.3	0.9	-0.5	-1.0	0.2	0.3	-0.0
Run reversals in cocaine runway, females	0.7	0.7	2.3	-0.5	0.3	-0.8	-0.2	1.5
Run reversals in cocaine runway, males	0.1	0.1	0.4	0.6	0.0	-0.2	-0.0	-0.5
Latency to leave start box in cocaine runway	0.7	0.9	1.8	0.4	1.3	-0.9	-0.8	0.9
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	0.1	0.6	-0.1	-0.3	0.5
Latency to leave start box in cocaine runway, M	0.6	0.5	1.2	0.1	1.1	-1.1	-0.4	0.4
Std. dev. time between licks in bursts	0.2	0.2	0.7	0.2	-0.8	-0.3	0.5	0.5
Total sessions with >9 infusions	0.6	0.7	1.8	0.1	1.3	-1.3	-0.0	0.5
Short access day 1 total inactive lever presses	2.2	2.9	3.8	2.0	1.8	-1.9	-1.9	0.4
Short access day 10 total inactive lever presses	0.1	0.3	0.8	0.9	0.1	-0.3	-0.1	-0.8
Short access day 1 total infusions	1.9	2.5	5.0	1.5	1.9	-2.2	-1.2	0.5
Short access day 10 total infusions	3.3	4.2	7.4	0.8	2.7	-2.7	-1.7	1.7
Short access total infusions	2.4	3.1	6.5	0.8	2.3	-2.5	-1.1	1.4
Short access day 1 locomotion	1.6	2.0	3.1	1.5	1.3	-1.8	-1.5	0.7
Short access day 10 total locomotion	1.4	2.7	4.0	1.2	1.8	-1.5	-2.0	1.5
Short access total locomotion	2.4	2.9	3.9	1.4	2.0	-1.9	-1.8	1.3
One hour access (0.3 mA shock)	6.1	7.0	12.4	3.0	2.4	-2.6	-3.5	1.2
Compulsive drug intake	2.9	3.4	7.4	-1.5	-2.7	2.1	1.6	-0.6
One hour access (shock baseline)	5.1	7.8	10.3	3.2	3.1	-2.9	-3.2	0.7
Social response proportion	0.4	0.4	1.0	-1.0	-0.4	0.6	0.7	0.0
Social responses	0.6	0.8	1.4	-0.6	-1.2	0.8	0.9	-0.8
Social time	0.4	0.6	1.3	-0.7	-0.8	0.5	1.1	-0.3
Soleus weight	1.8	5.2	13.8	3.7	1.9	-2.2	-1.8	-0.7
Bone: stiffness	0.7	1.2	4.7	-2.2	0.3	0.3	0.1	1.1
Tibialis anterior weight	4.8	16.1	40.4	-6.4	-3.6	3.8	3.4	1.4
Time to tail flick, vehicle, before self-admin	1.5	1.6	3.3	-0.6	1.2	-0.7	-1.6	1.8
Time to tail flick, vehicle, after self-admin	0.8	1.1	3.8	-0.8	0.6	-0.8	-0.0	2.0
Time to tail flick, test, before self-admin	3.6	3.7	4.6	1.6	1.9	-2.1	-2.2	1.9
Time to tail flick, test, after self-admin	0.1	0.1	0.4	-0.2	-0.1	0.3	0.2	-0.7
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	1.1	-0.5	-0.4	-0.1	1.1	0.3
Delta time to tail flick, test, before/after SA	4.8	5.0	7.8	-1.5	-2.3	2.8	2.2	-2.2
Tibia length	0.4	1.1	2.9	-1.7	-0.4	1.4	0.0	0.5
Ambulatory time before self-admin	0.2	0.4	0.8	-0.8	0.4	0.2	-0.4	0.9
Ambulatory time after self-admin	0.1	0.2	0.4	0.4	0.3	0.5	-0.6	-0.1
Bone: tissue strength	0.0	0.0	0.1	0.1	-0.0	0.1	0.1	0.3
Total heroin consumption	3.9	4.6	6.8	-2.6	-2.2	2.4	2.2	-0.5
Bone: trabecular number	0.6	1.0	2.6	-1.1	0.7	-0.3	-0.7	1.6
Bone: trabecular spacing	0.4	0.5	1.2	0.8	-0.7	-0.0	0.7	-1.1
Bone: trabecular thickness	0.5	0.6	1.4	0.7	1.2	-0.9	-0.6	0.4
Bone: trabecular tissue density	1.7	2.5	6.8	2.6	0.7	-1.0	-0.5	-1.9
Water consumed over 24 hours	1.5	2.1	3.4	-1.3	-1.8	1.7	1.3	-0.8
Number of responses in last shaping day	0.2	0.3	0.8	0.1	-0.9	0.4	0.6	-0.1