Atg2a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Atg2a	0.04	0.03	1.1e-04	0.02	0.02	0.01	0.02	1.9e-03	1.1e-03	2.6e-02	3.6e-03
2	Brain	gene expression	Atg2a	0.06	0.03	2.1e-06	0.07	0.06	0.06	0.06	8.0e-07	5.2e-06	3.2e-06	1.8e-06
3	pVTA	gene expression	Atg2a	0.03	0.02	9.9e-03	0.01	0.02	0	0.01	3.7e-02	5.0e-03	1.4e-01	7.4e-02
4	NAcc	gene expression	Atg2a	0.04	0.03	2.6e-08	0.06	0.05	0.04	0.05	6.2e-09	1.6e-08	7.8e-07	3.2e-08
5	RMTg	gene expression	Atg2a	0.17	0.11	4.1e-03	0.02	0.06	0.03	0.04	7.9e-02	1.1e-02	4.5e-02	3.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.4	0.8	1.7	-0.9	0.7	-0.7	0.6	-1.3
Area under the delay curve	0.1	0.1	0.7	-0.2	-0.0	-0.1	0.1	-0.8
BMI with tail	1.9	6.8	13.6	-2.5	2.3	-2.0	2.2	-3.7
BMI without tail	0.7	3.7	7.9	-1.8	1.4	-1.6	1.7	-2.8
Body weight	3.2	14.0	15.9	-3.8	3.7	-3.6	3.6	-4.0
Weight adjusted by age	0.6	1.8	2.4	-1.4	1.5	-1.4	1.4	-0.7
Bone surface	3.3	6.5	9.0	-2.8	3.0	-2.5	2.2	-2.2
Bone volume	0.9	1.7	2.8	-1.5	1.7	-1.2	0.9	-1.2
Breakpoint value in progressive ratio session	1.7	3.2	4.1	-2.0	1.9	-1.8	1.6	-1.4
Number of licking bursts	0.1	0.2	0.5	-0.5	0.7	-0.5	0.4	-0.3
Context. condit. distance diff. score	1.5	1.8	2.9	1.4	-1.7	1.4	-1.3	0.7
Locomotion velocity, session 1	0.1	0.1	0.2	-0.3	0.1	-0.4	0.4	-0.4
Locomotion distance, session 1	0.8	1.0	2.3	-0.9	0.7	-0.8	0.9	-1.5
Locomotion velocity, session 2	2.9	3.5	3.9	-1.9	1.8	-1.8	1.7	-2.0
Locomotion distance, session 2	1.0	1.5	2.7	-1.1	0.9	-1.0	1.2	-1.6
Locomotion velocity, session 3	0.2	0.2	0.3	0.4	-0.5	0.4	-0.2	-0.6
Locomotion distance, session 3	0.0	0.0	0.0	0.1	-0.2	0.1	-0.0	-0.1
Stereotopy head waving bouts, day 3	0.3	0.4	0.7	0.7	-0.8	0.7	-0.4	-0.5
Stereotopy head waving duration, day 3	0.5	0.6	0.8	0.9	-0.9	0.9	-0.7	0.2
Locomotion velocity, session 7	0.3	0.4	0.6	0.6	-0.7	0.8	-0.6	-0.4
Locomotion distance, session 7	0.2	0.2	0.8	-0.0	-0.2	-0.0	0.4	-0.9
Stereotopy head waving bouts, day 7	0.1	0.1	0.3	0.2	-0.1	0.4	-0.5	0.3
Stereotopy head waving duration, day 7	0.4	0.5	0.9	-0.8	1.0	-0.5	0.4	-0.5
Locomotion velocity, session 8	1.3	1.6	2.0	-1.3	1.0	-1.4	1.4	-1.2
Locomotion distance, session 8	0.2	0.2	0.4	0.4	-0.6	0.5	-0.5	-0.3
Degree of sensitization distance	0.1	0.1	0.6	-0.1	-0.1	-0.0	0.3	-0.8
Degree of sensitization stereotypy	0.1	0.2	0.5	-0.5	0.7	-0.2	0.1	-0.1
Conditioned locomotion	1.9	2.2	2.5	-1.5	1.6	-1.5	1.6	-1.2
Cocaine response after cond. corrected	0.6	0.9	1.8	1.1	-1.3	1.0	-0.7	0.3
Cocaine response after cond. not corrected	0.5	0.7	1.4	0.9	-1.2	0.8	-0.6	0.2
Cocaine response before conditioning	0.3	0.4	0.8	-0.8	0.9	-0.7	0.4	-0.2
Saline control response	4.8	6.7	7.2	-2.6	2.6	-2.7	2.7	-2.3
Bone: connectivity density	2.2	3.6	4.2	-2.0	1.9	-1.8	1.6	-2.0
Bone: cortical apparent density	0.0	0.1	0.1	-0.2	0.3	-0.2	0.3	0.1
Bone: cortical area	0.4	0.7	1.1	-1.0	1.1	-0.9	0.7	-0.5
Bone: cortical porosity	0.2	0.2	0.3	-0.4	0.5	-0.4	0.4	-0.5
Bone: cortical porosity	0.7	0.8	0.9	-0.9	0.9	-0.8	0.8	-0.9
Bone: cortical thickness	2.9	4.8	6.0	-2.3	2.2	-2.4	2.4	-1.5
Bone: cortical thickness	0.8	1.0	1.5	-0.9	0.7	-1.1	1.2	-0.9
Bone: cortical tissue density	0.1	0.2	0.2	-0.4	0.5	-0.4	0.5	0.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	-0.5	0.4	-0.4	0.4	-0.7
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.2	0.2	-0.1	0.1	-0.1
Condit. Reinf. active responses	0.0	0.0	0.2	-0.1	0.1	0.0	-0.1	-0.4
Condit. Reinf. inactive responses	0.1	0.2	0.4	0.4	-0.3	0.5	-0.6	-0.0
Incentive salience index mean	0.4	0.5	1.2	-0.7	0.5	-0.5	0.6	-1.1
Condit. Reinf. lever presses	0.3	0.4	0.7	-0.7	0.7	-0.6	0.4	-0.8
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	0.4	-0.3	0.6	-0.7	0.7
Condit. Reinf. active-inactive response ratio	0.9	1.5	2.3	1.1	-0.9	1.3	-1.5	1.1
Condit. Reinf. active responses	0.0	0.0	0.1	-0.2	0.3	-0.1	-0.0	0.0
Condit. Reinf. inactive responses	0.6	0.9	1.1	-1.0	0.8	-0.9	1.0	-1.1
Condit. Reinf. lever presses	1.0	1.5	2.9	-1.4	1.7	-1.2	1.0	-0.6
Condit. Reinf. lever reinforcers received	0.1	0.2	0.4	-0.5	0.7	-0.4	0.2	-0.1
Conditioned reinforcement - actives	0.1	0.5	2.0	0.4	0.1	0.4	-0.6	1.4
Conditioned reinforcement - inactives	2.3	6.2	8.2	2.4	-2.1	2.5	-2.6	2.9
Conditioned locomotion	8.8	13.0	14.4	3.7	-3.3	3.7	-3.6	3.8
Patch foraging indifference point 0 sec	0.0	0.0	0.1	0.2	-0.2	0.2	-0.2	0.0
Patch foraging indifference point AUC	0.9	2.1	3.3	-1.7	1.8	-1.6	1.2	-0.6
Delay disc. indifference point, 0s delay	0.2	0.2	0.7	0.1	-0.4	0.2	-0.2	-0.9
Delay disc. indifference point, 16s delay	0.6	0.8	1.1	0.9	-0.9	1.0	-1.0	0.6
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	0.2	-0.4	0.3	-0.4	-0.1
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	-0.0	-0.2	-0.2	0.2	-0.3
Delay disc. indifference point, 4s delay	0.2	0.2	1.0	-0.2	-0.2	-0.2	0.2	-1.0
Delay disc. indifference point, 8s delay	0.1	0.2	0.7	-0.2	0.0	-0.2	0.3	-0.8
Indifference point function ln k	2.7	8.2	12.5	3.3	-3.5	3.0	-2.5	1.6
Indifference point function log k	2.7	8.2	12.5	3.3	-3.5	3.0	-2.5	1.6
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	0.0	-0.1	-0.0	0.1	-0.1
Patch foraging total patch changes 12 sec	4.1	5.5	6.5	-2.5	2.5	-2.4	2.3	-1.9
Patch foraging total patch changes 18 sec	0.3	0.6	0.9	-0.9	0.9	-0.8	0.5	-0.7
Patch foraging total patch changes 24 sec	0.7	2.4	3.1	-1.7	1.7	-1.8	1.5	-0.9
Patch foraging total patch changes 6 sec	1.0	1.7	1.9	-1.3	1.1	-1.3	1.3	-1.4
Patch foraging time to switch 0 sec	0.6	2.1	2.8	-1.5	1.6	-1.2	1.2	-1.7
Patch foraging water rate 0 sec	1.7	6.5	7.3	2.7	-2.7	2.3	-2.3	2.7
Patch foraging water rate 12 sec	2.7	10.8	14.5	3.6	-3.8	3.1	-2.9	3.0
Patch foraging water rate 18 sec	1.3	2.9	4.5	1.9	-2.1	1.6	-1.4	1.2
Patch foraging water rate 24 sec	3.3	4.7	6.1	2.4	-2.5	2.1	-1.9	2.0
Patch foraging water rate 6 sec	2.9	4.3	6.7	2.4	-2.6	1.9	-1.6	1.7
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	0.4	-0.2	0.5	-0.0	-0.2
Distance traveled before self-admin	0.2	0.4	0.9	-0.8	1.0	-0.5	0.4	-0.4
Distance traveled after self-admin	0.1	0.1	0.3	-0.4	0.5	-0.3	0.3	0.0
Extensor digitorum longus weight	8.0	31.8	35.3	-5.9	5.9	-5.7	5.5	-5.1
Bone: elastic displacement	0.4	0.5	1.1	0.8	-1.0	0.5	-0.4	0.7
Bone: elastic work	1.4	1.8	2.5	-1.3	1.0	-1.5	1.6	-1.3
Bone: endosteal estimation	0.6	1.4	2.1	1.2	-1.3	1.4	-1.4	0.2
Bone: endosteal perimeter	1.0	2.5	3.9	1.6	-1.4	1.8	-2.0	0.9
Epididymis fat weight	2.5	12.7	14.8	3.6	-3.4	3.7	-3.9	3.3
Delta time in closed arm before/after self-admin	1.0	0.9	1.9	-0.7	0.4	-0.9	1.1	-1.4
Delta time in open arm before/after self-admin	0.1	0.2	0.5	-0.2	0.4	-0.0	-0.3	0.7
Diff in mean of infusions in LGA sessions	0.4	0.7	0.9	-0.9	0.8	-1.0	0.8	-0.6
Delay discount exponential model param	0.1	0.2	0.6	0.3	-0.0	0.2	-0.2	0.8
Extinction: sum of active levers before priming	1.7	2.6	3.1	-1.7	1.6	-1.5	1.5	-1.7
Active lever presses in extinction session 6	2.5	2.5	3.8	-1.8	1.9	-1.7	1.4	-0.9
Bone: final force	2.2	3.6	4.4	-2.0	2.1	-1.9	1.8	-1.6
Bone: final moment	2.1	3.4	4.1	-2.0	2.0	-1.9	1.7	-1.6
Food consumed during 24 hour testing period	0.1	0.2	0.7	0.0	0.3	0.0	-0.1	0.9
Glucose	1.9	3.0	4.1	1.9	-2.0	2.0	-1.7	0.5
Heart weight	0.5	0.8	1.5	0.7	-1.2	0.8	-0.6	-1.1
Delay discount hyperbolic model param	0.1	0.1	0.6	0.2	-0.0	0.1	-0.1	0.8
Intermittent access intake day 1-15 change	0.5	3.0	4.6	1.6	-1.4	1.6	-1.8	2.1
Intermittent access intake escalation	0.5	2.7	4.7	1.5	-1.2	1.5	-1.7	2.2
Intermittent access intake escalation 2	1.5	2.4	4.2	1.4	-1.1	1.5	-1.6	2.1
Intermitt. access day 1 inactive lever presses	0.0	0.3	0.4	0.5	-0.4	0.5	-0.5	0.6
Intermitt. access day 15 inactive lever presses	0.7	3.8	4.3	1.9	-1.6	2.1	-2.1	2.0
Intermitt. access escalation Index	1.0	3.2	4.2	1.9	-2.0	1.9	-1.8	1.1
Intermittent access day 1 total infusions	1.3	3.8	5.3	2.1	-1.8	2.3	-2.1	1.2
Intermittent access day 15 total infusions	4.1	10.1	11.5	3.2	-2.8	3.3	-3.4	3.2
Intermittent access terminal intake (last 3 days)	4.8	8.4	9.9	2.9	-2.5	3.1	-3.1	2.8
Intermittent access total infusions	4.9	5.8	7.2	2.5	-2.2	2.7	-2.6	2.0
Intermittent access day 1 locomotion	1.5	2.8	3.8	1.8	-1.6	1.9	-1.8	1.1
Intermittent access day 15 total locomotion	2.3	8.8	10.4	2.9	-2.5	3.1	-3.2	3.0
Intermittent access total locomotion	9.4	11.3	13.6	3.4	-2.9	3.7	-3.7	3.1
Intermittent access standard deviation	0.5	2.7	3.5	1.6	-1.4	1.6	-1.7	1.9
Left kidney weight	0.4	2.8	3.9	1.6	-1.8	1.8	-2.0	1.1
Right kidney weight	0.2	1.6	1.8	1.3	-1.2	1.3	-1.4	1.3
Cocaine induced anxiety	0.0	0.0	0.1	-0.1	0.1	0.0	-0.1	0.3
Post-drug Anxiety	0.5	0.6	0.8	-0.8	0.9	-0.8	0.7	-0.4
Baseline Anxiety	0.5	0.8	0.9	-0.8	0.7	-0.9	1.0	-0.9
Tail length	0.4	2.2	3.1	-1.6	1.4	-1.7	1.7	-1.0
Length with tail	2.2	9.7	11.3	-3.2	3.1	-3.4	3.3	-2.5
Length without tail	1.5	7.8	9.1	-2.8	2.8	-3.0	3.0	-2.2
Times rat made contact with spout	0.7	0.8	1.1	-0.9	0.8	-0.9	1.0	-1.0
Lifetime Intake	3.1	3.9	4.9	2.1	-1.8	2.2	-2.1	1.5
Liver weight, left	0.5	0.8	1.4	1.1	-1.2	0.9	-0.8	0.5
Liver weight, right	1.2	2.1	4.0	1.6	-2.0	1.4	-1.2	0.5
Locomotor activity	1.3	2.1	3.3	1.7	-1.8	1.3	-1.1	1.2
Locomotor testing distance	1.0	2.4	4.3	1.8	-2.1	1.4	-1.1	1.1
Locomotor testing rearing	0.6	2.1	3.8	1.7	-1.9	1.4	-1.1	1.0
Locomotion in novel chamber	5.7	7.6	8.5	2.9	-2.6	2.9	-2.8	2.6
Locomotion in novel chamber post-restriction	1.8	5.4	6.1	2.4	-2.1	2.4	-2.5	2.2
Fecal boli incidents, locomotor time 1	0.1	0.2	0.6	0.1	0.0	0.3	-0.8	0.7
Change in fecal boli incidents, locomotor task	0.3	0.3	0.9	-0.1	-0.0	-0.2	0.6	-0.9
Time >=10cm from walls, locomotor time 1	0.9	1.2	2.1	1.0	-0.8	1.3	-1.4	0.7
Bouts of movement, locomotor time 1	1.1	1.4	3.3	-1.2	1.8	-1.1	1.0	-0.2
Total resting periods, locomotor time 1	0.6	0.7	2.1	-0.8	1.4	-0.7	0.6	0.1
Rest time, locomotor task time 1	1.3	2.1	2.5	1.5	-1.1	1.4	-1.5	1.6
Distance moved, locomotor task time 1	0.1	0.3	0.9	-0.5	0.1	-0.4	0.5	-0.9
Vertical activity count, locomotor time 1	0.1	1.0	1.4	1.1	-1.2	1.0	-0.9	0.7
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.3	-0.0	0.3	0.2	-0.3	0.5
Bouts of movement, locomotor time 2	0.1	0.5	0.7	-0.7	0.9	-0.6	0.8	-0.4
Total resting periods, locomotor time 2	0.0	0.2	0.3	-0.4	0.6	-0.3	0.4	-0.2
Rest time, locomotor task time 2	1.6	2.7	3.2	1.8	-1.5	1.8	-1.7	1.3
Distance moved, locomotor task time 2	1.1	1.4	1.8	-1.3	1.2	-1.3	1.3	-0.8
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.0	-0.1	-0.3	0.3	0.2
Light reinforcement 1	0.0	0.1	0.2	0.3	-0.4	0.2	-0.3	0.5
Light reinforcement 2	1.0	2.2	3.4	1.4	-1.0	1.5	-1.7	1.8
Bone: marrow area	0.6	1.5	2.1	1.2	-1.4	1.4	-1.5	0.1
Bone: maximum diameter	0.0	0.1	0.3	-0.3	0.5	-0.2	-0.1	0.3
Bone: maximum force	2.4	4.7	6.1	-2.3	2.5	-2.0	1.9	-2.0
Bone: maximum moment	2.3	4.3	5.5	-2.2	2.3	-2.0	1.8	-2.0
Mean time between licks in bursts	0.2	1.1	1.8	-0.9	0.6	-1.1	1.4	-1.2
Mean num. licks in bursts	0.0	0.1	0.3	0.3	-0.5	0.2	-0.1	0.0
Cd content in liver	2.1	2.3	3.1	1.4	-1.2	1.5	-1.8	1.7
Co content in liver	0.7	0.9	1.5	1.0	-1.2	0.7	-0.6	0.9
Cu content in liver	0.0	0.0	0.1	0.1	-0.2	0.2	-0.2	-0.1
Fe content in liver	0.1	0.2	0.3	-0.4	0.3	-0.5	0.5	-0.3
K content in liver	0.9	0.9	2.0	-0.9	0.6	-0.9	0.8	-1.4
Mg content in liver	0.2	0.2	0.4	0.4	-0.6	0.3	-0.3	-0.4
Mn content in liver	2.6	2.9	4.5	-1.8	2.1	-1.7	1.6	-1.0
Na content in liver	0.3	0.4	0.6	-0.7	0.6	-0.8	0.6	-0.2
Rb content in liver	1.4	1.6	2.6	1.5	-1.6	1.4	-1.1	0.6
Se content in liver	0.5	0.5	0.9	0.6	-0.5	0.7	-0.8	1.0
Sr content in liver	2.4	2.1	2.9	-1.6	1.7	-1.6	1.4	-0.6
Zn content in liver	0.4	0.4	0.6	-0.7	0.5	-0.7	0.6	-0.8
Bone: minimum diameter	0.7	1.3	1.9	1.1	-1.2	1.3	-1.4	0.1
Time in familiar zone, hab. session 1	0.2	0.3	0.4	0.5	-0.6	0.6	-0.6	0.1
Time in novel zone, hab. session 1	0.0	0.0	0.1	0.2	-0.3	-0.0	0.1	0.2
Total zone transitions, hab. session 1	0.5	0.7	0.9	-0.9	0.9	-0.8	0.8	-0.8
Total locomotion distance, hab. session 1	0.2	0.3	0.5	0.6	-0.6	0.7	-0.6	0.0
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.1	-0.1	0.2	-0.1	-0.3
Time in familiar zone, hab. session 2	0.2	0.2	0.3	-0.3	-0.2	-0.5	0.6	-0.6
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.1	0.3	0.1	-0.1	0.0
Total zone transitions, hab. session 2	1.7	2.2	4.0	-1.4	1.3	-1.2	1.4	-2.0
Total locomotion distance, hab. session 2	0.2	0.3	1.3	-0.2	-0.0	-0.0	0.2	-1.1
Locomotion velocity, hab. session 2	0.1	0.2	0.7	0.1	-0.2	0.3	-0.1	-0.8
Novel to familiar place preference ratio	0.4	0.5	1.3	-0.8	1.2	-0.6	0.3	-0.1
Novelty place preference	0.1	0.2	0.6	-0.5	0.7	-0.2	-0.0	0.1
Time in novel zone, NPP test	0.1	0.1	0.4	-0.4	0.6	-0.2	-0.0	0.1
Total zone transitions, NPP test	2.2	3.3	3.7	-1.9	1.9	-1.7	1.7	-1.8
Total locomotion distance, NPP test	0.1	0.2	0.7	-0.3	0.2	-0.2	0.3	-0.9
Locomotion velocity, NPP test	0.1	0.2	0.5	-0.3	0.3	-0.2	0.3	-0.7
Intraocular pressure	1.8	2.9	5.5	1.5	-1.3	1.5	-1.8	2.3
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.3	-0.4	0.0	0.1	0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	0.0	-0.2	-0.2	0.4	-0.1
Parametrial fat weight	3.5	8.3	9.8	3.0	-3.0	3.1	-3.1	2.1
Pavlov. Cond. lever latency	0.3	0.4	0.7	0.6	-0.6	0.5	-0.6	0.8
Pavlov. Cond. magazine entry latency	0.2	0.3	0.6	-0.6	0.6	-0.4	0.4	-0.7
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.1	0.4	0.2	-0.2	0.1
Pavlov. Cond. index score	0.2	0.2	0.4	-0.5	0.6	-0.4	0.4	-0.3
Pavlov. Cond. latency score	0.1	0.2	0.3	-0.4	0.5	-0.3	0.3	-0.5
Pavlov. Cond. lever contacts	0.2	0.2	0.5	-0.4	0.3	-0.3	0.4	-0.7
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	0.5	-0.7	0.4	-0.3	0.0
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.7	1.0	-0.9	1.0	-1.1	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	-0.7	0.8	-0.5	0.5	-0.5
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.4	0.6	-0.3	0.3	-0.1
Pavlov. Cond. lever latency	0.3	0.4	1.0	0.7	-1.0	0.6	-0.4	0.1
Pavlov. Cond. magazine entry latency	3.4	4.8	5.9	-2.4	2.4	-2.2	2.0	-1.9
Pavlov. Cond. change in total contacts	0.4	1.1	2.7	-1.2	1.6	-0.9	0.6	-0.3
Pavlov. Cond. index score	1.4	2.2	3.8	-1.7	2.0	-1.4	1.2	-1.0
Pavlov. Cond. latency score	1.1	1.7	3.1	-1.5	1.8	-1.3	1.0	-0.9
Pavlov. Cond. lever contacts	0.3	0.4	1.0	-0.7	1.0	-0.6	0.4	-0.1
Pavlov. Cond. magazine entry number	5.5	7.1	10.2	2.9	-3.2	2.7	-2.4	1.9
Pavlov. Cond. intertrial magazine entries	0.7	1.6	1.8	1.3	-1.4	1.2	-1.3	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.8	4.6	-1.9	2.1	-1.6	1.4	-1.1
Pavlov. Cond. response bias	1.5	2.1	3.5	-1.6	1.9	-1.4	1.2	-0.9
Time in closed arm before self-admin	0.4	0.7	1.0	0.8	-0.6	0.9	-1.0	0.9
Time in closed arm after self-admin	0.2	0.2	0.5	0.6	-0.7	0.5	-0.3	-0.0
Time in open arm before self-admin	0.3	0.3	1.0	-0.1	-0.3	-0.4	0.7	-1.0
Time in open arm after self-admin	0.2	0.2	0.3	-0.5	0.4	-0.5	0.5	-0.4
Bone: periosteal estimation	0.0	0.1	0.2	0.1	-0.1	0.3	-0.5	-0.1
Bone: periosteal perimeter	0.0	0.1	0.1	-0.2	0.4	-0.1	-0.1	-0.3
Bone: post-yield work	0.3	0.5	1.5	-0.5	0.8	0.1	-0.1	-1.2
Progressive ratio test 1 active lever presses	0.4	0.7	0.9	0.8	-0.6	0.9	-0.9	1.0
Progressive ratio test 1 breakpoint	0.4	0.6	1.0	0.7	-0.5	0.8	-0.8	1.0
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.6	0.5	-0.3	0.5	-0.6	0.8
Progressive ratio test 2 active lever presses	3.3	4.7	5.4	2.1	-1.8	2.3	-2.3	2.3
Progressive ratio test 2 breakpoint	3.7	4.7	5.5	2.1	-1.8	2.2	-2.3	2.3
Progressive ratio test 2 inactive lever presses	4.4	13.9	15.3	3.8	-3.3	3.9	-3.9	3.7
Incentive Sensitization - Responses	0.0	0.1	0.2	0.3	-0.1	0.4	-0.4	0.3
Incentive Sensitization - Breakpoint	0.1	0.3	0.4	0.5	-0.4	0.6	-0.7	0.5
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.5	-0.6	0.9	-0.5	0.1	1.2
Progressive ratio	0.5	1.6	2.6	-1.2	1.4	-0.9	1.0	-1.6
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.3	0.2	-0.4	0.4	-0.5
Seeking ratio, punishment vs. effort	0.6	1.3	2.4	1.2	-1.6	0.9	-0.9	1.0
Retroperitoneal fat weight	8.4	37.6	44.6	6.6	-6.7	6.4	-6.1	4.6
Reaction time number correct	0.1	0.3	0.5	-0.6	0.6	-0.7	0.6	-0.2
Reaction time mean minus median	0.5	3.5	6.0	-2.1	2.5	-1.8	1.7	-1.1
Reaction time mean minus median AUC	0.3	1.9	3.3	-1.5	1.8	-1.3	1.3	-0.6
Reaction time num false alarms	0.1	0.2	0.6	0.4	-0.8	0.2	0.2	-0.4
Reaction time num false alarms AUC	0.1	0.3	0.8	-0.2	-0.1	-0.4	0.8	-0.9
Reaction time trials correct on left	0.1	0.3	0.5	-0.6	0.6	-0.7	0.6	-0.2
Reaction time trials on left	0.1	0.4	0.7	-0.7	0.7	-0.8	0.7	-0.2
Reaction time mean	0.0	0.1	0.2	-0.0	0.4	0.1	-0.1	0.5
Reaction time mean AUC	0.0	0.1	0.2	0.1	0.3	0.3	-0.3	0.5
Median of all reaction times	0.2	0.4	0.6	0.6	-0.3	0.7	-0.7	0.8
Reaction time omissions	1.3	2.0	3.4	-1.4	1.8	-1.3	1.5	-0.8
Reaction time false alarm rate	0.1	0.2	0.5	0.4	-0.7	0.2	0.1	-0.5
Reaction time premature initiation rate	3.7	5.7	7.5	-2.3	2.1	-2.5	2.7	-2.3
Reaction time premature initiations	2.5	7.7	10.1	-2.8	2.6	-3.0	3.2	-2.3
Std. dev. reaction times	0.3	0.8	1.9	-1.0	1.4	-0.8	0.8	-0.3
Reaction time trials completed	0.1	0.4	0.7	-0.7	0.7	-0.8	0.7	-0.2
Reaction time trials AUC	0.1	0.3	0.4	-0.5	0.5	-0.7	0.6	-0.2
Run reversals in cocaine runway, females	1.1	1.3	4.0	-0.8	0.4	-0.8	1.0	-2.0
Run reversals in cocaine runway, males	0.4	0.4	0.9	0.6	-0.6	0.4	-0.5	1.0
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.3	-0.4	0.4	-0.4	-0.2
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.1	-0.2	0.2	-0.2	-0.2
Latency to leave start box in cocaine runway, M	0.0	0.0	0.2	-0.0	-0.1	0.0	-0.0	-0.4
Std. dev. time between licks in bursts	0.1	0.2	0.6	-0.2	-0.1	-0.4	0.8	-0.6
Total sessions with >9 infusions	0.0	0.0	0.1	0.2	-0.0	0.3	-0.2	-0.3
Short access day 1 total inactive lever presses	1.5	3.0	3.7	1.9	-1.8	1.9	-1.7	1.2
Short access day 10 total inactive lever presses	0.1	0.5	0.8	0.8	-0.9	0.7	-0.6	0.3
Short access day 1 total infusions	0.9	1.8	2.6	1.5	-1.4	1.6	-1.4	0.7
Short access day 10 total infusions	0.4	0.7	1.3	0.9	-0.7	1.1	-1.0	0.0
Short access total infusions	0.4	0.5	0.9	0.8	-0.7	0.9	-0.8	-0.0
Short access day 1 locomotion	1.2	2.0	2.5	1.5	-1.5	1.6	-1.5	0.9
Short access day 10 total locomotion	0.4	1.7	2.2	1.3	-1.2	1.5	-1.5	1.0
Short access total locomotion	1.4	2.2	2.9	1.5	-1.4	1.7	-1.6	1.1
One hour access (0.3 mA shock)	7.8	9.2	10.0	3.2	-3.0	3.1	-3.1	2.7
Compulsive drug intake	2.6	3.9	4.8	-1.9	1.5	-2.2	2.2	-2.0
One hour access (shock baseline)	4.9	12.9	14.4	3.7	-3.2	3.8	-3.8	3.5
Social response proportion	0.4	0.5	0.9	-0.8	0.9	-0.7	0.7	-0.4
Social responses	0.2	0.3	0.4	-0.6	0.6	-0.6	0.7	-0.2
Social time	0.4	0.6	0.7	-0.7	0.8	-0.8	0.9	-0.4
Soleus weight	4.0	11.7	14.3	3.6	-3.8	3.5	-3.4	2.7
Bone: stiffness	1.5	2.8	4.3	-1.8	2.1	-1.5	1.4	-1.4
Tibialis anterior weight	9.7	33.4	40.6	-6.2	6.4	-6.1	5.7	-4.2
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.3	-0.5	0.5	-0.4	0.3	-0.6
Time to tail flick, vehicle, after self-admin	0.9	1.7	4.3	-1.2	0.8	-1.1	1.0	-2.1
Time to tail flick, test, before self-admin	1.3	1.5	2.3	1.4	-1.5	1.4	-1.2	0.1
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.2	0.2	-0.1	-0.0	0.3
Delta time to tail flick, vehicle, before/after SA	0.8	0.9	1.8	-0.9	0.6	-0.8	0.8	-1.4
Delta time to tail flick, test, before/after SA	1.0	1.3	2.2	-1.2	1.5	-1.3	1.0	0.6
Tibia length	0.4	1.1	2.7	-1.2	1.6	-1.0	0.5	0.3
Ambulatory time before self-admin	0.1	0.2	0.5	-0.5	0.7	-0.2	0.0	-0.0
Ambulatory time after self-admin	0.3	0.4	0.6	0.6	-0.4	0.7	-0.8	0.7
Bone: tissue strength	0.0	0.0	0.0	0.1	0.0	0.2	-0.1	0.2
Total heroin consumption	5.1	6.0	7.1	-2.7	2.7	-2.5	2.4	-1.8
Bone: trabecular number	0.4	0.7	1.0	-1.0	1.0	-0.7	0.5	-0.9
Bone: trabecular spacing	0.1	0.2	0.5	0.6	-0.7	0.4	-0.2	0.2
Bone: trabecular thickness	0.4	0.5	0.7	0.7	-0.7	0.8	-0.8	0.3
Bone: trabecular tissue density	3.8	6.7	7.1	2.7	-2.6	2.6	-2.6	2.5
Water consumed over 24 hours	0.8	1.5	1.7	-1.3	1.3	-1.3	1.3	-0.8
Number of responses in last shaping day	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.2	-0.0