Hub : Genes

Lrp5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose intron excision ratio chr1_210243963_210246692 0.05 0.04 2.1e-03 0.02 0.02 0.01 0.01 5.0e-03 5.8e-03 1.5e-02 7.7e-03
2 Adipose intron excision ratio chr1_210250359_210250960 0.05 0.03 3.0e-03 0.02 0.02 0.01 0.01 6.0e-03 6.1e-03 1.1e-02 9.6e-03
3 Adipose mRNA stability Lrp5 0.06 0.05 9.4e-03 0.02 0.01 0.01 0.01 3.0e-03 1.4e-02 2.6e-02 1.0e-02
4 Adipose gene expression Lrp5 0.12 0.07 1.3e-09 0.03 0.07 0.06 0.07 1.3e-04 1.9e-08 9.9e-07 6.4e-08
5 Liver gene expression Lrp5 0.11 0.08 2.0e-03 0.01 0.02 0.02 0.01 2.2e-02 1.3e-03 1.5e-03 6.7e-02
6 BLA gene expression Lrp5 0.13 0.09 7.7e-07 0.11 0.1 0.09 0.09 1.4e-06 6.4e-06 1.6e-05 1.3e-05
7 IC gene expression Lrp5 0.1 0.07 1.3e-03 0.07 0.08 0.06 0.07 6.0e-04 3.7e-04 1.4e-03 6.9e-04
8 PL gene expression Lrp5 0.1 0.06 1.6e-10 0.06 0.1 0.09 0.09 2.5e-07 1.5e-10 3.1e-10 4.1e-10
9 NAcc gene expression Lrp5 0.06 0.04 5.5e-09 0.06 0.06 0.05 0.06 7.0e-09 2.2e-09 1.7e-08 3.3e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density2.44.27.4-0.70.70.52.3-1.82.72.72.62.6
Area under the delay curve0.70.81.5-0.00.0-0.10.8-1.01.21.21.21.2
BMI with tail2.07.111.8-2.12.12.13.4-1.33.43.22.72.8
BMI without tail1.13.36.1-2.12.12.22.5-0.02.01.71.21.3
Body weight1.77.314.0-3.73.73.73.51.02.41.80.91.0
Weight adjusted by age0.40.71.7-1.31.31.10.70.80.3-0.0-0.3-0.3
Bone surface3.36.010.4-2.12.11.83.2-1.13.12.92.52.5
Bone volume1.93.56.1-0.90.90.72.2-1.52.52.42.22.3
Breakpoint value in progressive ratio session1.21.53.2-1.81.81.71.50.70.90.60.20.3
Number of licking bursts0.10.10.1-0.10.10.00.3-0.30.40.40.40.4
Context. condit. distance diff. score0.50.61.41.2-1.2-1.2-0.6-0.9-0.10.10.40.4
Locomotion velocity, session 10.00.00.1-0.00.0-0.30.0-0.10.10.10.10.2
Locomotion distance, session 11.41.73.0-0.60.60.21.5-1.11.71.71.61.6
Locomotion velocity, session 21.11.33.1-1.81.81.71.30.90.60.3-0.1-0.1
Locomotion distance, session 20.71.01.7-1.21.20.81.3-0.21.21.10.80.9
Locomotion velocity, session 31.31.52.80.0-0.0-0.11.1-1.41.51.61.61.7
Locomotion distance, session 30.10.10.20.0-0.0-0.10.3-0.40.40.40.50.5
Stereotopy head waving bouts, day 31.01.22.20.6-0.6-0.10.7-1.41.21.31.51.4
Stereotopy head waving duration, day 30.70.91.91.1-1.1-0.8-0.1-1.40.60.81.01.0
Locomotion velocity, session 70.80.81.4-0.00.00.10.9-1.01.21.21.21.2
Locomotion distance, session 70.20.30.7-0.70.70.30.8-0.10.70.60.40.4
Stereotopy head waving bouts, day 71.11.32.30.5-0.5-0.10.7-1.51.31.41.51.5
Stereotopy head waving duration, day 71.41.72.9-0.60.60.91.5-1.01.71.71.51.6
Locomotion velocity, session 80.70.92.1-1.51.51.21.20.60.60.40.10.1
Locomotion distance, session 80.30.40.90.5-0.5-0.9-0.0-1.00.40.60.70.7
Degree of sensitization distance0.40.40.8-0.60.60.40.9-0.20.80.70.60.6
Degree of sensitization stereotypy0.60.71.2-0.30.30.50.9-0.71.11.01.01.0
Conditioned locomotion2.02.34.8-1.71.71.40.12.2-0.9-1.3-1.7-1.6
Cocaine response after cond. corrected0.10.10.10.3-0.3-0.3-0.1-0.40.10.20.30.2
Cocaine response after cond. not corrected0.20.30.60.3-0.3-0.20.2-0.70.50.60.70.7
Cocaine response before conditioning0.10.10.2-0.30.30.30.4-0.30.50.50.40.5
Saline control response1.72.24.9-2.22.22.21.80.91.00.70.10.2
Bone: connectivity density3.85.99.7-1.91.91.73.1-1.33.12.92.52.6
Bone: cortical apparent density0.30.50.9-0.70.70.7-0.01.0-0.5-0.6-0.8-0.8
Bone: cortical area0.40.71.3-1.01.00.90.01.1-0.5-0.6-0.9-0.8
Bone: cortical porosity0.00.00.1-0.10.10.10.2-0.10.30.20.20.2
Bone: cortical porosity0.10.20.3-0.60.60.50.50.30.30.20.10.1
Bone: cortical thickness3.15.19.8-2.92.92.70.63.1-1.0-1.5-2.2-2.1
Bone: cortical thickness1.11.22.7-1.71.71.40.61.4-0.2-0.4-0.8-0.8
Bone: cortical tissue density0.50.61.2-0.90.90.90.11.1-0.5-0.6-0.8-0.8
Condit. Reinf. active minus inactive responses0.30.40.7-0.30.30.30.6-0.60.80.80.80.8
Condit. Reinf. active-inactive response ratio0.20.20.40.1-0.1-0.10.3-0.60.50.60.60.6
Condit. Reinf. active responses0.00.00.1-0.00.00.20.1-0.20.20.30.30.3
Condit. Reinf. inactive responses0.10.10.20.3-0.3-0.1-0.40.1-0.4-0.3-0.3-0.3
Incentive salience index mean0.20.30.5-0.40.40.30.6-0.40.70.70.60.7
Condit. Reinf. lever presses0.00.00.0-0.20.20.1-0.10.2-0.1-0.1-0.1-0.1
Condit. Reinf. active minus inactive responses1.01.22.60.8-0.8-0.80.3-1.61.01.21.41.5
Condit. Reinf. active-inactive response ratio1.31.52.91.5-1.5-1.7-0.7-1.60.30.61.01.0
Condit. Reinf. active responses1.21.63.10.2-0.20.01.0-1.51.61.71.71.7
Condit. Reinf. inactive responses1.21.52.7-1.01.01.51.7-0.41.51.31.11.1
Condit. Reinf. lever presses1.11.52.4-0.90.90.81.5-0.71.61.51.31.4
Condit. Reinf. lever reinforcers received1.31.83.2-0.10.10.31.3-1.41.71.81.81.8
Conditioned reinforcement - actives0.50.81.40.4-0.4-0.4-1.10.7-1.1-1.2-1.1-1.1
Conditioned reinforcement - inactives1.21.73.82.0-2.0-1.9-1.4-1.3-0.6-0.20.40.3
Conditioned locomotion4.96.312.83.4-3.4-3.6-3.4-1.2-2.1-1.6-0.7-0.7
Patch foraging indifference point 0 sec0.10.30.90.9-0.9-0.5-0.2-0.5-0.10.10.20.2
Patch foraging indifference point AUC0.71.01.7-1.31.31.20.11.3-0.5-0.7-1.0-0.9
Delay disc. indifference point, 0s delay1.61.73.10.3-0.3-0.11.1-1.61.51.71.71.8
Delay disc. indifference point, 16s delay0.60.61.41.1-1.1-1.2-0.7-0.9-0.00.10.40.4
Delay disc. indifference point, 2s delay0.50.51.30.5-0.5-0.60.1-1.20.60.80.90.9
Delay disc. indifference point, 24s delay0.20.20.5-0.00.00.4-0.10.7-0.4-0.5-0.6-0.6
Delay disc. indifference point, 4s delay0.40.50.9-0.30.3-0.10.6-0.70.90.90.80.9
Delay disc. indifference point, 8s delay0.30.30.7-0.00.00.30.7-0.50.90.80.70.7
Indifference point function ln k1.93.37.62.8-2.8-2.7-2.0-1.1-1.0-0.7-0.1-0.1
Indifference point function log k1.93.37.62.8-2.8-2.7-2.0-1.1-1.0-0.7-0.1-0.1
Patch foraging total patch changes 0 sec0.10.20.40.6-0.6-0.1-0.30.1-0.4-0.4-0.3-0.4
Patch foraging total patch changes 12 sec1.31.64.1-1.91.92.01.41.00.60.3-0.2-0.2
Patch foraging total patch changes 18 sec0.20.30.7-0.60.60.80.70.10.40.40.20.2
Patch foraging total patch changes 24 sec0.40.71.3-1.01.01.20.41.1-0.2-0.4-0.7-0.7
Patch foraging total patch changes 6 sec0.71.02.2-0.90.91.41.5-0.11.11.00.80.8
Patch foraging time to switch 0 sec1.93.96.1-1.51.51.52.5-1.22.52.42.12.2
Patch foraging water rate 0 sec3.47.212.32.6-2.6-2.6-3.50.9-3.2-3.0-2.4-2.5
Patch foraging water rate 12 sec4.49.316.83.4-3.4-3.3-4.10.6-3.4-3.1-2.4-2.4
Patch foraging water rate 18 sec1.11.63.21.6-1.6-1.8-1.7-0.1-1.2-1.1-0.7-0.7
Patch foraging water rate 24 sec3.14.47.31.9-1.9-1.9-2.71.0-2.5-2.4-2.0-2.1
Patch foraging water rate 6 sec2.33.35.51.3-1.3-1.4-2.31.1-2.3-2.3-2.0-2.0
Seeking ratio, delayed vs. immediate footshock0.60.71.3-0.10.10.20.8-0.91.11.11.11.1
Distance traveled before self-admin0.30.40.7-0.20.20.20.6-0.60.70.80.80.8
Distance traveled after self-admin0.00.00.1-0.10.10.00.2-0.10.20.20.20.2
Extensor digitorum longus weight3.614.333.5-5.85.85.63.63.81.00.2-1.2-1.1
Bone: elastic displacement2.32.64.60.0-0.0-0.2-1.51.8-2.0-2.1-2.1-2.1
Bone: elastic work1.41.93.8-1.71.71.40.32.0-0.7-1.0-1.4-1.3
Bone: endosteal estimation1.12.54.81.8-1.8-1.9-0.2-2.20.81.11.61.5
Bone: endosteal perimeter2.34.99.82.7-2.7-2.5-0.4-3.11.21.62.32.2
Epididymis fat weight2.27.616.64.1-4.1-4.0-3.4-1.9-1.6-1.1-0.1-0.2
Delta time in closed arm before/after self-admin0.80.81.7-1.31.31.10.61.1-0.1-0.3-0.6-0.6
Delta time in open arm before/after self-admin0.30.30.60.2-0.2-0.40.3-0.70.60.70.70.8
Diff in mean of infusions in LGA sessions0.40.51.4-1.01.01.20.50.70.1-0.1-0.3-0.3
Delay discount exponential model param0.50.61.20.1-0.10.0-0.70.8-1.1-1.0-1.0-1.0
Extinction: sum of active levers before priming1.51.73.2-1.51.51.51.8-0.01.41.30.90.9
Active lever presses in extinction session 60.70.71.7-1.31.31.00.51.10.0-0.3-0.6-0.5
Bone: final force0.81.22.4-1.61.61.41.50.31.00.80.40.5
Bone: final moment0.71.12.3-1.51.51.31.40.40.90.70.40.4
Food consumed during 24 hour testing period0.30.40.80.6-0.6-0.7-0.90.1-0.7-0.7-0.5-0.5
Glucose2.03.27.01.7-1.7-1.7-0.0-2.61.21.62.12.1
Heart weight1.21.83.40.6-0.6-0.30.8-1.81.51.71.81.8
Delay discount hyperbolic model param0.60.61.20.1-0.10.1-0.70.9-1.1-1.0-1.1-1.0
Intermittent access intake day 1-15 change1.12.34.72.1-2.1-2.2-2.0-0.8-1.2-0.9-0.4-0.4
Intermittent access intake escalation1.02.14.02.0-2.0-2.0-2.0-0.6-1.2-1.0-0.5-0.5
Intermittent access intake escalation 21.41.63.31.8-1.8-1.7-1.6-0.7-0.9-0.7-0.2-0.3
Intermitt. access day 1 inactive lever presses0.00.00.10.3-0.3-0.1-0.1-0.0-0.1-0.1-0.1-0.1
Intermitt. access day 15 inactive lever presses0.61.22.41.5-1.5-1.2-0.5-1.50.40.61.00.9
Intermitt. access escalation Index1.62.24.31.8-1.8-1.8-2.1-0.2-1.6-1.3-0.9-0.9
Intermittent access day 1 total infusions1.93.06.51.4-1.4-1.30.3-2.51.51.82.22.1
Intermittent access day 15 total infusions2.63.88.62.9-2.9-2.8-1.8-2.2-0.40.10.90.8
Intermittent access terminal intake (last 3 days)2.53.36.42.5-2.5-2.3-1.2-2.40.20.71.41.3
Intermittent access total infusions1.82.24.51.8-1.8-1.7-0.6-2.10.60.91.41.4
Intermittent access day 1 locomotion1.01.32.91.0-1.0-1.00.1-1.70.81.11.41.4
Intermittent access day 15 total locomotion1.93.47.72.6-2.6-2.8-1.7-2.2-0.20.31.00.9
Intermittent access total locomotion3.84.69.52.9-2.9-3.1-1.6-2.80.00.61.41.4
Intermittent access standard deviation0.30.61.51.2-1.2-1.1-0.7-0.9-0.20.10.40.4
Left kidney weight0.62.66.32.5-2.5-2.3-1.7-1.4-0.6-0.30.30.2
Right kidney weight0.52.13.92.0-2.0-1.9-2.0-0.5-1.2-1.0-0.5-0.5
Cocaine induced anxiety0.10.10.20.1-0.1-0.20.2-0.40.40.40.40.4
Post-drug Anxiety0.20.30.6-0.60.60.60.80.10.60.50.30.3
Baseline Anxiety0.20.30.7-0.70.70.80.50.70.0-0.1-0.3-0.3
Tail length0.62.45.2-1.81.81.80.52.3-0.7-1.1-1.6-1.5
Length with tail1.35.511.3-3.43.43.41.82.90.1-0.6-1.4-1.4
Length without tail1.03.47.5-2.72.72.71.62.10.3-0.2-0.9-0.8
Times rat made contact with spout0.70.81.3-0.70.70.61.1-0.41.21.10.90.9
Lifetime Intake1.01.22.51.4-1.4-1.1-0.4-1.60.50.71.11.0
Liver weight, left0.50.91.40.9-0.9-0.6-1.20.5-1.2-1.1-1.0-1.0
Liver weight, right0.81.52.61.5-1.5-1.4-1.6-0.1-1.2-1.1-0.8-0.8
Locomotor activity0.81.22.41.3-1.3-1.6-1.40.1-1.1-1.0-0.7-0.7
Locomotor testing distance0.91.62.71.6-1.6-1.6-1.60.1-1.1-1.1-0.8-0.8
Locomotor testing rearing0.40.82.31.3-1.3-1.5-0.7-1.00.10.20.50.5
Locomotion in novel chamber3.34.29.73.1-3.1-3.0-2.0-2.0-0.5-0.10.70.6
Locomotion in novel chamber post-restriction1.62.66.32.4-2.4-2.5-1.8-1.4-0.8-0.40.20.2
Fecal boli incidents, locomotor time 10.00.00.10.2-0.2-0.4-0.3-0.0-0.0-0.1-0.1-0.0
Change in fecal boli incidents, locomotor task0.10.10.2-0.30.30.40.5-0.00.40.30.30.2
Time >=10cm from walls, locomotor time 11.81.94.11.2-1.2-1.30.1-2.01.11.31.71.6
Bouts of movement, locomotor time 10.80.91.9-1.01.00.70.21.4-0.6-0.8-1.1-1.0
Total resting periods, locomotor time 10.50.61.2-0.60.60.2-0.21.1-0.7-0.8-1.0-1.0
Rest time, locomotor task time 11.51.93.61.7-1.7-1.5-1.9-0.0-1.5-1.3-1.0-1.0
Distance moved, locomotor task time 10.71.11.9-0.40.40.21.1-1.01.31.41.41.4
Vertical activity count, locomotor time 10.30.71.40.9-0.9-1.0-0.1-1.20.50.70.90.9
Time >=10cm from walls, locomotor time 20.20.20.40.2-0.2-0.5-0.60.3-0.6-0.6-0.5-0.5
Bouts of movement, locomotor time 20.20.30.6-0.70.70.80.50.60.10.0-0.2-0.2
Total resting periods, locomotor time 20.00.10.2-0.40.40.40.40.20.20.20.10.1
Rest time, locomotor task time 21.21.53.01.7-1.7-1.7-0.7-1.70.20.50.90.9
Distance moved, locomotor task time 20.70.92.0-1.11.11.00.21.4-0.5-0.7-1.0-1.0
Vertical activity count, locomotor time 21.41.93.5-0.30.30.2-0.91.8-1.6-1.8-1.9-1.9
Light reinforcement 10.20.61.60.8-0.8-0.8-1.2-0.1-0.9-0.8-0.5-0.6
Light reinforcement 21.32.03.71.8-1.8-1.9-1.9-0.4-1.3-1.0-0.6-0.6
Bone: marrow area1.22.65.01.9-1.9-1.9-0.2-2.20.91.21.61.6
Bone: maximum diameter0.10.10.30.4-0.4-0.5-0.6-0.0-0.4-0.4-0.2-0.2
Bone: maximum force1.83.25.7-1.51.51.32.4-0.82.32.11.81.8
Bone: maximum moment1.62.85.1-1.51.51.22.3-0.72.12.01.61.7
Mean time between licks in bursts0.20.41.3-0.90.91.10.70.60.20.1-0.1-0.1
Mean num. licks in bursts0.00.10.1-0.00.00.10.3-0.20.40.40.30.3
Cd content in liver1.01.12.71.6-1.6-1.6-1.1-0.9-0.4-0.20.20.2
Co content in liver1.72.03.40.5-0.5-0.6-1.71.2-1.8-1.9-1.7-1.7
Cu content in liver0.00.00.10.2-0.2-0.1-0.20.1-0.2-0.2-0.2-0.2
Fe content in liver0.00.10.2-0.40.40.10.20.30.0-0.1-0.2-0.2
K content in liver0.50.50.8-0.60.60.60.9-0.30.90.80.60.7
Mg content in liver0.40.40.80.7-0.7-0.5-0.1-0.90.40.50.70.6
Mn content in liver1.21.33.1-1.71.71.81.30.80.70.40.00.1
Na content in liver0.50.61.0-0.00.00.1-0.70.9-1.0-1.0-1.0-1.0
Rb content in liver1.01.22.41.2-1.2-1.2-0.2-1.50.70.81.11.1
Se content in liver0.30.40.70.6-0.6-0.50.2-0.90.60.60.80.7
Sr content in liver1.41.22.3-1.51.51.40.41.5-0.5-0.6-1.0-0.9
Zn content in liver0.40.40.9-0.60.60.80.11.0-0.4-0.6-0.7-0.7
Bone: minimum diameter1.42.65.31.3-1.3-1.50.3-2.31.41.62.02.0
Time in familiar zone, hab. session 10.40.40.80.7-0.7-0.8-0.2-0.90.30.40.60.6
Time in novel zone, hab. session 10.10.10.1-0.20.20.30.00.4-0.2-0.2-0.3-0.3
Total zone transitions, hab. session 10.30.40.7-0.80.80.60.80.00.60.50.40.4
Total locomotion distance, hab. session 10.30.40.90.8-0.8-0.9-0.5-0.80.00.20.40.4
Locomotion velocity, hab. session 10.10.10.20.4-0.4-0.5-0.3-0.4-0.00.10.20.2
Time in familiar zone, hab. session 20.50.61.2-0.80.80.50.01.1-0.5-0.7-0.9-0.8
Time in novel zone, hab. session 20.80.81.50.3-0.3-0.10.7-1.21.11.21.21.2
Total zone transitions, hab. session 23.34.37.4-1.11.10.82.5-1.62.72.72.42.5
Total locomotion distance, hab. session 21.11.42.50.1-0.1-0.21.0-1.41.41.51.61.6
Locomotion velocity, hab. session 21.01.32.30.4-0.4-0.50.7-1.51.31.41.51.5
Novel to familiar place preference ratio0.40.40.7-0.20.20.50.8-0.50.80.80.80.8
Novelty place preference0.40.40.70.1-0.10.30.6-0.70.80.80.90.8
Time in novel zone, NPP test0.40.40.80.1-0.10.30.6-0.70.80.90.90.8
Total zone transitions, NPP test1.11.62.8-1.21.20.61.7-0.51.61.51.21.3
Total locomotion distance, NPP test0.30.40.70.1-0.1-0.50.4-0.80.70.80.80.9
Locomotion velocity, NPP test0.20.20.40.2-0.2-0.50.2-0.60.50.60.60.6
Intraocular pressure1.01.42.50.7-0.7-0.8-1.60.8-1.5-1.5-1.3-1.3
Delta distance traveled before/after self-admin0.10.10.3-0.10.1-0.2-0.20.4-0.4-0.5-0.5-0.5
Delta ambulatory time before/after self-admin0.20.20.4-0.20.20.1-0.20.6-0.4-0.5-0.6-0.6
Parametrial fat weight1.43.47.92.6-2.6-2.8-1.6-2.2-0.20.31.00.9
Pavlov. Cond. lever latency0.20.30.50.6-0.6-0.7-0.7-0.1-0.5-0.4-0.3-0.3
Pavlov. Cond. magazine entry latency0.60.81.50.3-0.3-0.20.7-1.11.11.21.21.2
Pavlov. Cond. change in total contacts0.40.40.90.7-0.7-0.6-0.0-0.90.50.60.80.8
Pavlov. Cond. index score0.00.00.10.2-0.2-0.2-0.0-0.30.10.10.20.2
Pavlov. Cond. latency score0.10.10.20.1-0.1-0.00.2-0.40.40.40.40.4
Pavlov. Cond. lever contacts0.10.10.1-0.20.20.30.4-0.20.40.40.30.3
Pavlov. Cond. magazine entry number0.00.00.1-0.30.30.10.20.10.10.0-0.0-0.0
Pavlov. Cond. intertrial magazine entries0.50.61.20.3-0.3-0.2-1.00.7-1.1-1.0-1.0-1.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.1-0.1-0.10.0-0.30.20.20.20.3
Pavlov. Cond. response bias0.00.00.10.2-0.2-0.1-0.2-0.0-0.1-0.1-0.1-0.1
Pavlov. Cond. lever latency0.00.00.00.2-0.20.00.0-0.0-0.00.00.0-0.0
Pavlov. Cond. magazine entry latency2.83.46.4-2.02.01.72.5-0.32.21.91.51.5
Pavlov. Cond. change in total contacts0.60.91.5-0.40.40.21.0-0.91.21.21.21.2
Pavlov. Cond. index score0.81.11.8-1.01.00.81.4-0.41.31.21.01.0
Pavlov. Cond. latency score0.60.81.3-0.90.90.71.1-0.31.11.00.80.9
Pavlov. Cond. lever contacts0.00.00.1-0.20.20.10.1-0.10.20.20.10.2
Pavlov. Cond. magazine entry number3.24.07.52.3-2.3-2.0-2.70.2-2.3-2.0-1.5-1.6
Pavlov. Cond. intertrial magazine entries0.81.12.41.6-1.6-0.9-1.4-0.2-1.1-0.9-0.5-0.6
Pavlov. Cond. lever-magazine prob. diff.1.01.42.4-1.21.21.01.5-0.31.41.31.01.0
Pavlov. Cond. response bias0.81.11.8-1.01.00.81.3-0.41.31.21.01.1
Time in closed arm before self-admin0.60.81.61.1-1.1-1.0-0.2-1.30.50.60.90.9
Time in closed arm after self-admin0.00.00.10.0-0.0-0.1-0.30.1-0.3-0.3-0.2-0.2
Time in open arm before self-admin0.70.81.7-1.01.01.10.21.3-0.5-0.7-0.9-0.9
Time in open arm after self-admin0.30.40.7-0.80.80.70.90.20.60.50.30.3
Bone: periosteal estimation0.10.20.40.5-0.5-0.6-0.2-0.60.20.20.40.4
Bone: periosteal perimeter0.40.61.20.5-0.5-0.40.4-1.10.80.91.01.0
Bone: post-yield work6.08.816.10.6-0.6-0.62.3-3.63.63.84.04.0
Progressive ratio test 1 active lever presses0.00.10.10.1-0.10.0-0.30.2-0.3-0.3-0.3-0.3
Progressive ratio test 1 breakpoint0.00.10.10.1-0.10.0-0.30.3-0.3-0.3-0.3-0.3
Progressive ratio test 1 inactive lever presses0.00.00.00.1-0.10.1-0.10.1-0.1-0.1-0.1-0.1
Progressive ratio test 2 active lever presses0.81.02.31.5-1.5-1.3-0.9-1.0-0.20.00.40.4
Progressive ratio test 2 breakpoint0.80.92.21.5-1.5-1.3-1.0-0.9-0.2-0.10.30.3
Progressive ratio test 2 inactive lever presses2.74.410.13.2-3.2-2.9-2.2-2.1-0.6-0.10.70.6
Incentive Sensitization - Responses0.40.51.00.0-0.00.00.6-0.81.01.01.01.0
Incentive Sensitization - Breakpoint0.40.50.90.2-0.2-0.20.4-0.90.90.91.01.0
Sum of active levers in priming session hrs 5-63.02.85.0-0.10.1-0.0-1.51.9-2.1-2.2-2.2-2.2
Progressive ratio2.94.67.8-0.90.90.92.6-1.72.82.82.62.6
Food seeking constrained by brief footshock0.20.20.4-0.40.40.60.6-0.20.50.50.40.4
Seeking ratio, punishment vs. effort1.82.64.60.8-0.8-0.8-2.01.1-2.1-2.1-1.9-1.9
Retroperitoneal fat weight4.017.239.56.3-6.3-5.9-4.8-3.4-2.2-1.20.30.2
Reaction time number correct0.30.61.4-0.80.80.5-0.11.2-0.7-0.7-0.9-0.9
Reaction time mean minus median0.61.62.9-1.61.61.51.70.21.41.10.60.7
Reaction time mean minus median AUC0.41.02.3-1.51.51.31.10.80.70.4-0.00.0
Reaction time num false alarms0.60.91.6-0.30.30.0-0.71.1-1.2-1.2-1.3-1.2
Reaction time num false alarms AUC0.50.81.7-1.01.00.70.01.3-0.7-0.8-1.0-1.0
Reaction time trials correct on left0.30.61.4-0.80.80.5-0.11.2-0.7-0.7-0.9-0.9
Reaction time trials on left0.40.71.7-0.90.90.6-0.11.3-0.7-0.8-1.0-0.9
Reaction time mean0.20.40.6-0.10.1-0.00.5-0.70.80.80.80.8
Reaction time mean AUC0.30.40.80.1-0.1-0.20.5-0.90.80.80.90.9
Median of all reaction times0.40.51.20.3-0.3-0.40.3-1.10.80.91.01.0
Reaction time omissions1.11.74.3-2.12.11.71.50.90.70.50.00.1
Reaction time false alarm rate0.20.30.5-0.30.30.2-0.20.7-0.6-0.6-0.7-0.7
Reaction time premature initiation rate1.41.94.0-2.02.02.01.71.10.70.5-0.1-0.0
Reaction time premature initiations1.62.96.5-2.52.52.41.62.00.2-0.1-0.8-0.7
Std. dev. reaction times0.30.61.1-0.80.80.71.0-0.10.90.80.60.6
Reaction time trials completed0.40.71.7-0.90.90.6-0.11.3-0.7-0.8-1.0-0.9
Reaction time trials AUC0.30.61.3-0.80.80.5-0.11.1-0.6-0.7-0.9-0.8
Run reversals in cocaine runway, females1.21.22.0-1.11.10.61.4-0.51.31.31.11.1
Run reversals in cocaine runway, males0.50.61.1-0.20.20.0-0.61.0-0.9-0.9-1.0-1.0
Latency to leave start box in cocaine runway0.91.01.90.4-0.4-0.40.6-1.41.11.21.41.3
Latency to leave start box in cocaine runway, F0.70.81.60.1-0.1-0.30.7-1.21.01.21.31.3
Latency to leave start box in cocaine runway, M0.00.00.10.0-0.00.10.2-0.20.20.20.20.2
Std. dev. time between licks in bursts0.91.32.7-1.01.00.8-0.21.6-1.0-1.2-1.4-1.4
Total sessions with >9 infusions0.10.20.3-0.20.20.50.5-0.20.60.50.40.4
Short access day 1 total inactive lever presses0.71.02.41.4-1.4-1.5-1.2-0.8-0.5-0.30.10.1
Short access day 10 total inactive lever presses0.00.00.00.0-0.0-0.00.1-0.20.20.20.20.2
Short access day 1 total infusions0.50.61.71.3-1.3-0.8-0.6-0.90.00.20.50.4
Short access day 10 total infusions1.21.63.00.3-0.3-0.00.9-1.61.51.61.71.7
Short access total infusions0.40.50.90.2-0.20.20.5-0.80.90.91.00.9
Short access day 1 locomotion0.50.61.21.1-1.1-1.0-0.6-0.9-0.00.20.50.5
Short access day 10 total locomotion0.40.71.70.7-0.7-0.8-0.0-1.30.40.81.01.0
Short access total locomotion0.50.61.41.0-1.0-0.9-0.3-1.20.20.50.80.8
One hour access (0.3 mA shock)2.32.66.42.5-2.5-2.2-1.6-1.7-0.5-0.00.60.5
Compulsive drug intake1.72.04.2-1.81.81.90.82.0-0.3-0.7-1.2-1.2
One hour access (shock baseline)2.94.410.23.2-3.2-2.9-2.2-2.1-0.7-0.20.60.6
Social response proportion0.60.71.2-0.90.90.51.1-0.21.00.90.70.8
Social responses0.30.41.2-1.11.10.50.30.8-0.0-0.2-0.4-0.4
Social time0.30.30.7-0.90.90.80.70.50.50.2-0.00.0
Soleus weight2.88.114.43.7-3.7-3.8-3.8-0.5-2.8-2.3-1.4-1.5
Bone: stiffness1.72.74.8-1.01.00.82.1-1.12.22.11.91.9
Tibialis anterior weight5.016.933.4-5.85.85.62.35.3-0.8-1.6-3.0-2.9
Time to tail flick, vehicle, before self-admin1.41.52.6-0.40.40.41.4-1.21.51.61.61.6
Time to tail flick, vehicle, after self-admin1.82.34.0-1.41.41.52.0-0.51.91.71.41.4
Time to tail flick, test, before self-admin1.51.63.20.6-0.6-0.80.5-1.81.21.51.71.7
Time to tail flick, test, after self-admin0.10.10.20.1-0.10.4-0.10.2-0.3-0.3-0.3-0.3
Delta time to tail flick, vehicle, before/after SA0.60.61.2-1.01.01.11.00.20.70.60.30.3
Delta time to tail flick, test, before/after SA3.13.26.1-0.70.71.2-0.82.5-1.9-2.1-2.4-2.4
Tibia length0.51.52.7-0.60.60.4-0.81.6-1.3-1.5-1.6-1.6
Ambulatory time before self-admin0.40.61.2-0.00.0-0.00.7-0.91.01.11.11.1
Ambulatory time after self-admin0.70.81.70.9-0.9-1.0-0.0-1.30.60.81.01.0
Bone: tissue strength0.20.20.50.4-0.4-0.4-0.0-0.70.40.50.60.6
Total heroin consumption2.22.57.0-2.22.22.61.81.30.80.4-0.1-0.1
Bone: trabecular number2.33.96.8-0.80.80.82.3-1.62.62.62.42.4
Bone: trabecular spacing0.81.01.80.6-0.6-0.4-1.20.7-1.3-1.3-1.2-1.2
Bone: trabecular thickness1.31.62.90.5-0.5-0.70.7-1.71.41.51.71.7
Bone: trabecular tissue density4.26.211.63.1-3.1-3.1-3.4-0.3-2.6-2.2-1.5-1.5
Water consumed over 24 hours0.70.91.8-1.11.11.11.3-0.11.10.90.70.7
Number of responses in last shaping day0.10.10.2-0.30.30.30.00.5-0.2-0.3-0.4-0.4