Lrp5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	intron excision ratio	chr1_200821108_200821709	0.05	0.03	2.4e-03	0.01	0.02	0.02	0.01	1.4e-02	5.5e-03	3.3e-03	6.7e-03
2	Adipose	intron excision ratio	chr1_200814711_200817440	0.05	0.04	1.7e-03	0.02	0.02	0.02	0.02	3.0e-03	5.4e-03	6.3e-03	6.3e-03
3	Adipose	gene expression	Lrp5	0.11	0.06	1.7e-09	0.03	0.07	0.06	0.06	1.8e-04	3.1e-08	2.5e-07	2.4e-07
4	BLA	gene expression	Lrp5	0.17	0.11	1.3e-07	0.12	0.12	0.11	0.11	3.4e-07	6.3e-07	1.5e-06	1.4e-06
5	NAcc	gene expression	Lrp5	0.04	0.03	3.3e-05	0.01	0.04	0.03	0.03	1.1e-02	4.6e-05	1.3e-04	1.8e-04
6	PL	gene expression	Lrp5	0.1	0.06	6.1e-11	0.09	0.1	0.1	0.1	6.4e-10	2.0e-11	9.5e-11	1.3e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	2.3	3.8	6.2	-0.6	0.4	2.0	-2.5	2.4	2.5
Area under the delay curve	0.7	0.8	1.4	0.1	0.0	0.7	-1.1	1.2	1.2
BMI with tail	2.6	8.3	13.6	-2.6	2.5	3.7	-3.4	2.2	2.6
BMI without tail	1.6	3.3	5.5	-1.7	1.6	2.4	-2.2	1.3	1.6
Body weight	2.0	8.5	17.3	-4.2	3.9	3.7	-2.2	0.0	0.7
Weight adjusted by age	0.8	0.9	2.3	-1.5	1.3	1.0	-0.4	-0.3	-0.1
Bone surface	3.1	5.5	8.6	-1.8	1.7	2.9	-2.8	2.1	2.4
Bone volume	1.9	3.2	5.0	-0.8	0.6	2.0	-2.2	2.1	2.2
Breakpoint value in progressive ratio session	1.3	1.4	2.8	-1.7	1.6	1.5	-0.9	-0.0	0.3
Number of licking bursts	0.1	0.1	0.3	-0.1	0.1	0.3	-0.5	0.4	0.4
Context. condit. distance diff. score	0.5	0.6	1.4	1.1	-1.2	-0.6	-0.0	0.6	0.4
Locomotion velocity, session 1	0.0	0.0	0.0	0.0	-0.1	0.1	-0.2	0.1	0.1
Locomotion distance, session 1	1.4	1.9	3.1	-0.7	0.6	1.5	-1.8	1.5	1.6
Locomotion velocity, session 2	1.3	1.5	3.5	-1.9	1.8	1.4	-0.6	-0.4	-0.1
Locomotion distance, session 2	0.9	1.2	1.8	-1.0	1.1	1.3	-1.3	0.8	0.9
Locomotion velocity, session 3	1.3	1.5	2.7	-0.1	0.1	1.1	-1.6	1.6	1.6
Locomotion distance, session 3	0.1	0.1	0.2	-0.0	-0.0	0.3	-0.4	0.4	0.4
Stereotopy head waving bouts, day 3	1.0	1.2	2.3	0.4	-0.4	0.7	-1.3	1.5	1.5
Stereotopy head waving duration, day 3	0.7	0.8	1.4	1.0	-1.0	-0.1	-0.6	1.2	1.0
Locomotion velocity, session 7	0.8	0.8	1.6	-0.2	-0.0	0.9	-1.1	1.2	1.3
Locomotion distance, session 7	0.2	0.3	0.6	-0.6	0.4	0.7	-0.6	0.3	0.4
Stereotopy head waving bouts, day 7	0.9	1.0	2.1	0.7	-0.6	0.3	-1.0	1.5	1.4
Stereotopy head waving duration, day 7	1.7	2.1	3.3	-0.9	0.9	1.7	-1.8	1.5	1.6
Locomotion velocity, session 8	0.8	1.0	2.1	-1.5	1.3	1.2	-0.7	-0.1	0.1
Locomotion distance, session 8	0.2	0.3	0.7	0.6	-0.6	0.0	-0.5	0.8	0.7
Degree of sensitization distance	0.4	0.4	0.6	-0.6	0.4	0.8	-0.7	0.5	0.6
Degree of sensitization stereotypy	0.7	0.7	1.2	-0.4	0.4	0.9	-1.1	1.0	1.0
Conditioned locomotion	1.9	2.2	3.6	-1.6	1.7	0.1	1.1	-1.9	-1.7
Cocaine response after cond. corrected	0.1	0.1	0.1	0.4	-0.4	-0.1	-0.0	0.3	0.3
Cocaine response after cond. not corrected	0.3	0.3	0.6	0.4	-0.4	0.2	-0.5	0.8	0.7
Cocaine response before conditioning	0.2	0.2	0.6	-0.1	0.2	0.4	-0.8	0.5	0.5
Saline control response	1.6	2.1	4.6	-2.1	2.0	1.8	-0.9	-0.1	0.2
Bone: connectivity density	3.6	5.7	8.6	-1.7	1.6	2.9	-2.9	2.2	2.5
Bone: cortical apparent density	0.3	0.5	1.0	-1.0	1.0	0.5	-0.0	-0.6	-0.4
Bone: cortical area	0.3	0.5	0.9	-0.7	0.9	-0.0	0.6	-0.9	-0.9
Bone: cortical porosity	0.0	0.0	0.1	0.0	0.0	0.1	-0.2	0.3	0.3
Bone: cortical porosity	0.2	0.2	0.4	-0.6	0.6	0.5	-0.2	-0.0	0.1
Bone: cortical thickness	2.6	4.2	8.3	-2.5	2.9	0.6	0.9	-2.3	-2.0
Bone: cortical thickness	1.1	1.3	3.1	-1.6	1.7	0.6	0.2	-1.1	-0.9
Bone: cortical tissue density	0.4	0.6	1.2	-1.1	1.1	0.5	-0.0	-0.6	-0.5
Condit. Reinf. active minus inactive responses	0.4	0.4	0.7	-0.1	0.3	0.6	-0.8	0.8	0.8
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.2	-0.1	0.2	-0.5	0.7	0.6
Condit. Reinf. active responses	0.0	0.0	0.1	0.1	0.1	0.1	-0.3	0.3	0.3
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.3	-0.1	-0.3	0.3	-0.2	-0.3
Incentive salience index mean	0.2	0.3	0.5	-0.2	0.3	0.5	-0.7	0.7	0.6
Condit. Reinf. lever presses	0.0	0.0	0.0	0.0	0.1	-0.1	0.1	-0.2	-0.2
Condit. Reinf. active minus inactive responses	1.1	1.4	2.8	1.1	-0.9	0.2	-1.1	1.7	1.5
Condit. Reinf. active-inactive response ratio	1.3	1.4	3.1	1.8	-1.5	-0.7	-0.3	1.2	1.0
Condit. Reinf. active responses	1.3	1.8	3.4	0.3	-0.2	0.9	-1.8	1.8	1.8
Condit. Reinf. inactive responses	1.3	1.7	2.7	-1.1	1.0	1.6	-1.6	1.0	1.2
Condit. Reinf. lever presses	1.0	1.4	2.3	-0.8	0.9	1.4	-1.5	1.1	1.2
Condit. Reinf. lever reinforcers received	1.4	2.0	3.5	-0.0	0.0	1.2	-1.9	1.8	1.8
Conditioned reinforcement - actives	0.7	0.7	1.1	0.6	-0.6	-1.0	1.1	-0.7	-0.8
Conditioned reinforcement - inactives	3.6	4.1	10.1	3.2	-2.8	-2.3	1.0	0.3	-0.1
Conditioned locomotion	6.7	8.0	13.6	3.7	-3.4	-3.7	2.5	-0.8	-1.4
Patch foraging indifference point 0 sec	0.1	0.2	0.7	0.7	-0.8	-0.3	-0.0	0.3	0.2
Patch foraging indifference point AUC	0.7	0.8	1.6	-1.3	1.2	0.5	0.1	-0.9	-0.7
Delay disc. indifference point, 0s delay	1.4	1.5	2.8	0.1	0.0	1.0	-1.6	1.7	1.7
Delay disc. indifference point, 16s delay	0.7	0.7	1.7	1.3	-1.2	-0.7	0.1	0.6	0.4
Delay disc. indifference point, 2s delay	0.4	0.4	0.8	0.6	-0.6	0.1	-0.6	0.9	0.9
Delay disc. indifference point, 24s delay	0.2	0.2	0.4	-0.3	0.4	-0.1	0.4	-0.6	-0.6
Delay disc. indifference point, 4s delay	0.3	0.3	0.6	-0.1	0.2	0.6	-0.8	0.7	0.7
Delay disc. indifference point, 8s delay	0.4	0.4	0.6	-0.3	0.3	0.7	-0.8	0.6	0.7
Indifference point function ln k	2.3	3.2	7.3	2.7	-2.6	-2.1	1.1	0.2	-0.1
Indifference point function log k	2.3	3.2	7.3	2.7	-2.6	-2.1	1.1	0.2	-0.1
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	0.4	-0.5	-0.4	0.3	-0.3	-0.3
Patch foraging total patch changes 12 sec	1.2	1.5	3.7	-1.9	1.7	1.4	-0.6	-0.4	-0.1
Patch foraging total patch changes 18 sec	0.2	0.3	0.5	-0.6	0.4	0.7	-0.6	0.2	0.3
Patch foraging total patch changes 24 sec	0.6	0.7	1.5	-1.2	1.0	0.5	0.2	-0.8	-0.6
Patch foraging total patch changes 6 sec	0.8	1.2	2.1	-1.1	1.0	1.4	-1.2	0.6	0.8
Patch foraging time to switch 0 sec	2.6	4.1	6.1	-1.5	1.4	2.5	-2.5	1.9	2.1
Patch foraging water rate 0 sec	5.0	7.9	12.7	2.7	-2.6	-3.6	3.2	-2.1	-2.5
Patch foraging water rate 12 sec	6.6	10.1	16.9	3.5	-3.1	-4.1	3.4	-2.0	-2.5
Patch foraging water rate 18 sec	1.4	1.9	3.3	1.8	-1.4	-1.8	1.4	-0.5	-0.8
Patch foraging water rate 24 sec	3.2	4.5	7.1	1.8	-1.6	-2.7	2.6	-1.8	-2.0
Patch foraging water rate 6 sec	2.5	3.7	5.8	1.5	-1.4	-2.3	2.4	-1.8	-2.0
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.3	-0.3	0.3	0.8	-1.2	1.0	1.0
Distance traveled before self-admin	0.1	0.1	0.2	-0.3	0.2	0.5	-0.4	0.3	0.4
Distance traveled after self-admin	0.0	0.0	0.1	-0.1	-0.0	0.2	-0.3	0.3	0.3
Extensor digitorum longus weight	3.4	13.2	30.4	-5.5	5.5	3.7	-1.1	-1.7	-0.9
Bone: elastic displacement	2.2	2.5	4.4	0.4	-0.2	-1.6	2.0	-2.0	-2.1
Bone: elastic work	1.2	1.6	2.6	-1.4	1.5	0.2	0.8	-1.6	-1.4
Bone: endosteal estimation	1.0	2.3	4.2	1.8	-2.1	-0.3	-0.8	1.8	1.5
Bone: endosteal perimeter	2.2	4.5	8.2	2.6	-2.9	-0.6	-1.0	2.5	2.2
Epididymis fat weight	1.8	4.3	10.4	3.2	-2.9	-2.4	1.0	0.6	0.1
Delta time in closed arm before/after self-admin	0.5	0.5	0.9	-0.8	0.9	0.3	0.3	-0.8	-0.7
Delta time in open arm before/after self-admin	0.1	0.1	0.3	0.5	-0.5	-0.2	-0.1	0.4	0.3
Diff in mean of infusions in LGA sessions	0.2	0.2	0.5	-0.7	0.6	0.3	0.0	-0.4	-0.3
Delay discount exponential model param	0.5	0.6	1.0	-0.0	-0.1	-0.7	0.9	-1.0	-1.0
Extinction: sum of active levers before priming	2.8	2.7	5.0	-2.2	1.9	2.2	-1.5	0.5	0.8
Active lever presses in extinction session 6	1.0	1.0	1.8	-0.9	1.1	0.1	0.6	-1.4	-1.2
Bone: final force	1.1	1.7	3.1	-1.7	1.8	1.7	-1.1	0.3	0.5
Bone: final moment	0.9	1.5	2.7	-1.6	1.6	1.5	-1.0	0.2	0.5
Food consumed during 24 hour testing period	0.4	0.4	0.8	0.8	-0.6	-0.9	0.7	-0.4	-0.5
Glucose	1.5	2.2	3.6	1.7	-1.7	-0.3	-1.0	1.9	1.6
Heart weight	0.8	1.1	2.8	1.6	-1.7	-0.9	0.2	0.6	0.4
Delay discount hyperbolic model param	0.5	0.6	1.0	-0.0	-0.1	-0.7	1.0	-1.0	-1.0
Intermittent access intake day 1-15 change	1.4	1.4	2.4	1.5	-1.4	-1.6	1.1	-0.4	-0.6
Intermittent access intake escalation	1.1	1.1	2.4	1.5	-1.4	-1.3	0.7	0.0	-0.2
Intermittent access intake escalation 2	0.6	0.6	1.1	0.9	-0.9	-1.0	0.7	-0.3	-0.5
Intermitt. access day 1 inactive lever presses	0.7	0.8	1.7	1.3	-1.3	-1.0	0.2	0.4	0.2
Intermitt. access day 15 inactive lever presses	1.0	1.1	2.6	1.6	-1.4	-0.9	0.3	0.8	0.6
Intermitt. access escalation Index	2.1	1.8	3.7	1.9	-1.8	-1.7	1.0	-0.2	-0.5
Intermittent access day 1 total infusions	2.7	3.1	6.0	1.9	-1.7	-0.1	-1.1	2.5	2.2
Intermittent access day 15 total infusions	3.8	4.3	10.6	3.2	-2.9	-1.9	0.4	1.4	0.9
Intermittent access terminal intake (last 3 days)	2.6	2.9	6.6	2.6	-2.3	-1.2	-0.0	1.6	1.2
Intermittent access total infusions	1.8	2.0	4.0	2.0	-1.8	-0.7	-0.4	1.6	1.4
Intermittent access day 1 locomotion	1.8	1.9	3.9	1.0	-0.9	0.4	-1.4	2.0	1.9
Intermittent access day 15 total locomotion	2.3	2.5	6.3	2.5	-2.3	-1.5	0.3	1.0	0.6
Intermittent access total locomotion	3.2	3.7	7.5	2.7	-2.5	-1.0	-0.5	2.0	1.7
Intermittent access standard deviation	0.5	0.5	1.4	1.2	-0.8	-0.9	0.4	0.0	-0.1
Left kidney weight	0.9	2.4	4.0	2.0	-1.8	-2.0	1.4	-0.6	-0.9
Right kidney weight	1.0	2.9	4.7	1.7	-1.6	-2.2	1.9	-1.3	-1.5
Cocaine induced anxiety	0.0	0.0	0.1	0.4	-0.3	-0.1	0.1	-0.0	-0.0
Post-drug Anxiety	0.6	0.6	1.1	-1.0	1.1	0.4	0.2	-0.9	-0.8
Baseline Anxiety	1.2	1.3	3.0	-1.7	1.7	0.8	0.0	-0.9	-0.7
Tail length	0.6	2.0	3.5	-1.7	1.5	0.3	0.8	-1.9	-1.6
Length with tail	1.3	4.9	11.1	-3.3	3.0	1.7	0.1	-2.0	-1.5
Length without tail	1.3	2.8	6.7	-2.6	2.4	1.7	-0.4	-1.0	-0.6
Times rat made contact with spout	0.8	0.9	1.7	-0.7	0.7	1.1	-1.3	0.8	0.9
Lifetime Intake	1.4	1.6	3.0	1.7	-1.5	-0.5	-0.4	1.5	1.3
Liver weight, left	0.1	0.2	0.4	0.6	-0.5	-0.4	0.2	0.1	-0.0
Liver weight, right	0.3	0.6	1.0	0.5	-0.2	-0.9	1.0	-0.7	-0.8
Locomotor activity	0.8	1.2	2.1	1.4	-1.2	-1.4	1.1	-0.5	-0.7
Locomotor testing distance	0.9	1.4	2.4	1.4	-1.2	-1.5	1.3	-0.5	-0.8
Locomotor testing rearing	0.5	0.8	1.9	1.4	-1.2	-0.7	0.0	0.8	0.6
Locomotion in novel chamber	3.1	3.8	9.0	3.0	-2.8	-2.0	0.7	1.0	0.5
Locomotion in novel chamber post-restriction	1.8	2.1	5.4	2.3	-1.8	-1.7	0.9	0.3	-0.1
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	0.4	-0.2	-0.2	0.1	0.1	0.1
Change in fecal boli incidents, locomotor task	0.3	0.3	0.6	-0.5	0.5	0.8	-0.6	0.3	0.4
Time >=10cm from walls, locomotor time 1	2.0	2.0	3.7	1.4	-1.2	0.3	-1.2	1.9	1.8
Bouts of movement, locomotor time 1	0.5	0.6	1.1	-0.8	0.8	0.2	0.4	-1.1	-0.9
Total resting periods, locomotor time 1	0.4	0.4	0.9	-0.5	0.4	-0.0	0.5	-0.9	-0.9
Rest time, locomotor task time 1	1.7	1.9	3.3	1.5	-1.2	-1.8	1.6	-0.9	-1.1
Distance moved, locomotor task time 1	0.9	1.0	1.6	-0.3	0.2	1.0	-1.3	1.2	1.3
Vertical activity count, locomotor time 1	0.6	0.6	1.2	1.0	-1.1	-0.4	-0.3	0.9	0.8
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.3	0.3	-0.3	-0.5	0.5	-0.4	-0.4
Bouts of movement, locomotor time 2	0.3	0.3	0.7	-0.8	0.8	0.5	-0.1	-0.4	-0.3
Total resting periods, locomotor time 2	0.1	0.1	0.3	-0.5	0.5	0.4	-0.2	-0.1	-0.0
Rest time, locomotor task time 2	1.2	1.4	3.5	1.9	-1.5	-0.7	-0.2	1.2	0.9
Distance moved, locomotor task time 2	0.6	0.7	1.3	-1.1	1.0	0.2	0.4	-1.0	-0.8
Vertical activity count, locomotor time 2	1.6	1.7	3.4	-0.5	0.3	-0.9	1.5	-1.8	-1.8
Light reinforcement 1	0.5	0.9	1.8	1.2	-0.9	-1.3	1.0	-0.4	-0.6
Light reinforcement 2	1.7	2.2	4.2	2.1	-1.7	-2.0	1.3	-0.3	-0.7
Bone: marrow area	1.0	2.3	4.3	1.8	-2.1	-0.4	-0.8	1.8	1.5
Bone: maximum diameter	0.1	0.3	0.4	0.6	-0.5	-0.7	0.6	-0.2	-0.3
Bone: maximum force	2.3	3.9	6.1	-1.7	1.6	2.5	-2.4	1.7	1.9
Bone: maximum moment	1.9	3.2	5.1	-1.5	1.4	2.3	-2.2	1.5	1.7
Mean time between licks in bursts	0.5	0.7	1.7	-1.3	1.3	0.9	-0.4	-0.4	-0.2
Mean num. licks in bursts	0.1	0.1	0.1	-0.1	0.1	0.3	-0.4	0.3	0.3
Cd content in liver	1.2	1.3	2.2	1.4	-1.5	-1.4	1.1	-0.3	-0.5
Co content in liver	1.0	1.1	1.7	0.6	-0.4	-1.2	1.3	-1.2	-1.3
Cu content in liver	0.1	0.1	0.3	-0.6	0.4	0.2	0.2	-0.4	-0.3
Fe content in liver	0.0	0.0	0.1	-0.1	0.3	0.1	-0.2	-0.0	-0.0
K content in liver	2.0	2.0	3.0	-1.3	1.1	1.7	-1.7	1.2	1.4
Mg content in liver	2.3	2.4	4.5	-0.0	-0.2	1.3	-1.9	2.1	2.1
Mn content in liver	0.8	0.9	1.9	-1.4	1.3	1.2	-0.8	0.0	0.2
Na content in liver	0.2	0.2	0.5	-0.2	0.2	-0.3	0.4	-0.7	-0.7
Rb content in liver	1.6	2.0	4.1	1.3	-1.3	0.2	-1.1	2.0	1.9
Se content in liver	0.5	0.6	1.2	0.3	-0.5	0.4	-0.9	1.1	1.1
Sr content in liver	1.4	1.3	2.6	-1.5	1.6	0.6	0.2	-1.2	-1.0
Zn content in liver	0.5	0.5	1.3	-1.2	1.0	0.7	-0.2	-0.3	-0.2
Bone: minimum diameter	1.3	2.4	4.8	1.3	-1.4	0.3	-1.4	2.2	2.0
Time in familiar zone, hab. session 1	0.3	0.3	0.6	0.7	-0.8	-0.2	-0.3	0.7	0.6
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.2	0.3	0.0	0.2	-0.3	-0.3
Total zone transitions, hab. session 1	0.3	0.4	0.6	-0.7	0.8	0.8	-0.6	0.3	0.4
Total locomotion distance, hab. session 1	0.3	0.4	0.9	0.9	-0.9	-0.6	0.1	0.5	0.4
Locomotion velocity, hab. session 1	0.1	0.1	0.3	0.5	-0.4	-0.4	0.1	0.3	0.2
Time in familiar zone, hab. session 2	0.6	0.6	1.0	-0.8	0.8	0.1	0.6	-1.0	-0.9
Time in novel zone, hab. session 2	0.9	0.9	1.7	0.2	-0.3	0.6	-1.1	1.3	1.3
Total zone transitions, hab. session 2	3.7	4.7	7.9	-1.3	1.1	2.5	-2.8	2.3	2.5
Total locomotion distance, hab. session 2	1.0	1.3	2.6	0.0	-0.1	0.9	-1.4	1.6	1.6
Locomotion velocity, hab. session 2	0.9	1.2	2.5	0.4	-0.4	0.6	-1.3	1.6	1.5
Novel to familiar place preference ratio	0.5	0.5	0.9	-0.5	0.5	0.8	-0.9	0.7	0.8
Novelty place preference	0.4	0.4	0.7	-0.2	0.2	0.6	-0.8	0.8	0.9
Time in novel zone, NPP test	0.5	0.5	0.8	-0.2	0.2	0.7	-0.9	0.8	0.9
Total zone transitions, NPP test	1.3	1.8	2.9	-1.2	1.1	1.7	-1.7	1.1	1.3
Total locomotion distance, NPP test	0.3	0.4	0.8	0.2	-0.2	0.4	-0.7	0.9	0.8
Locomotion velocity, NPP test	0.1	0.2	0.5	0.2	-0.3	0.2	-0.5	0.7	0.6
Intraocular pressure	1.1	1.5	2.2	0.9	-0.7	-1.5	1.5	-1.1	-1.3
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.0	-0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.1	-0.2	0.3	-0.0	0.1	-0.2	-0.2
Parametrial fat weight	1.1	2.1	4.3	2.0	-2.1	-0.9	-0.2	1.5	1.2
Pavlov. Cond. lever latency	0.1	0.2	0.3	0.4	-0.3	-0.6	0.5	-0.3	-0.4
Pavlov. Cond. magazine entry latency	0.8	1.1	2.0	0.2	-0.4	0.8	-1.2	1.4	1.4
Pavlov. Cond. change in total contacts	0.5	0.5	0.8	0.8	-0.8	-0.1	-0.5	0.9	0.8
Pavlov. Cond. index score	0.1	0.1	0.2	0.4	-0.4	-0.1	-0.1	0.3	0.2
Pavlov. Cond. latency score	0.1	0.1	0.2	0.3	-0.3	0.1	-0.3	0.5	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.1	0.0	-0.0	0.2	-0.3	0.3	0.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.4	0.5	0.3	-0.2	0.0	0.1
Pavlov. Cond. intertrial magazine entries	0.5	0.7	1.0	0.4	-0.2	-0.9	1.0	-0.9	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.3	-0.3	-0.0	-0.2	0.2	0.2
Pavlov. Cond. response bias	0.0	0.1	0.1	0.3	-0.4	-0.1	-0.1	0.2	0.2
Pavlov. Cond. lever latency	0.0	0.0	0.1	-0.0	-0.2	-0.2	0.3	-0.3	-0.3
Pavlov. Cond. magazine entry latency	2.9	3.3	5.5	-1.9	1.9	2.3	-2.0	1.1	1.4
Pavlov. Cond. change in total contacts	0.7	0.9	1.6	-0.4	0.4	1.1	-1.3	1.1	1.1
Pavlov. Cond. index score	0.8	1.1	1.7	-0.9	1.0	1.3	-1.2	0.8	0.9
Pavlov. Cond. latency score	0.7	0.8	1.2	-0.7	0.8	1.1	-1.1	0.7	0.8
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.1	0.2	-0.2	0.2	-0.2	-0.2
Pavlov. Cond. magazine entry number	3.6	4.4	7.2	2.2	-2.2	-2.7	2.3	-1.2	-1.6
Pavlov. Cond. intertrial magazine entries	0.9	1.2	2.1	1.3	-1.4	-1.3	1.0	-0.3	-0.5
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	2.3	-1.1	1.2	1.5	-1.3	0.8	1.0
Pavlov. Cond. response bias	0.5	0.6	1.0	-0.8	0.9	1.0	-0.9	0.5	0.6
Time in closed arm before self-admin	0.1	0.1	0.2	0.4	-0.4	-0.1	-0.3	0.5	0.4
Time in closed arm after self-admin	0.1	0.1	0.2	-0.1	0.3	-0.1	0.3	-0.5	-0.4
Time in open arm before self-admin	0.2	0.2	0.4	-0.6	0.5	0.3	0.1	-0.4	-0.4
Time in open arm after self-admin	0.0	0.0	0.1	-0.0	0.0	-0.1	0.2	-0.3	-0.3
Bone: periosteal estimation	0.1	0.2	0.5	0.6	-0.7	-0.2	-0.1	0.4	0.3
Bone: periosteal perimeter	0.2	0.4	0.8	0.5	-0.6	0.1	-0.5	0.9	0.8
Bone: post-yield work	5.5	7.5	14.8	0.5	-0.8	2.0	-3.3	3.9	3.8
Progressive ratio test 1 active lever presses	0.9	1.0	2.0	1.4	-1.3	-1.2	0.8	-0.0	-0.2
Progressive ratio test 1 breakpoint	0.9	0.9	1.7	1.3	-1.2	-1.2	0.9	-0.2	-0.4
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.5	0.7	-0.7	-0.5	0.1	0.3	0.2
Progressive ratio test 2 active lever presses	1.6	1.7	4.1	2.0	-1.8	-1.5	0.8	0.4	0.1
Progressive ratio test 2 breakpoint	2.3	2.6	5.4	2.3	-2.1	-2.0	1.3	-0.1	-0.4
Progressive ratio test 2 inactive lever presses	3.7	4.3	10.3	3.2	-2.9	-2.1	0.8	1.2	0.7
Incentive Sensitization - Responses	0.2	0.2	0.5	0.7	-0.6	-0.3	0.1	0.3	0.2
Incentive Sensitization - Breakpoint	0.3	0.3	0.8	0.9	-0.8	-0.5	0.2	0.3	0.1
Sum of active levers in priming session hrs 5-6	2.1	2.0	4.0	-0.2	0.3	-1.1	1.7	-2.0	-2.0
Progressive ratio	4.2	4.8	7.3	-1.7	1.4	2.7	-2.7	2.0	2.3
Food seeking constrained by brief footshock	0.3	0.4	0.8	-0.9	0.8	0.7	-0.4	0.1	0.2
Seeking ratio, punishment vs. effort	2.5	3.0	4.8	1.3	-1.1	-2.1	2.2	-1.6	-1.9
Retroperitoneal fat weight	2.8	9.4	21.9	4.7	-4.4	-3.4	1.5	0.9	0.2
Reaction time number correct	0.3	0.5	0.9	-0.5	0.7	-0.1	0.5	-1.0	-0.9
Reaction time mean minus median	1.1	1.5	2.6	-1.6	1.4	1.6	-1.0	0.5	0.7
Reaction time mean minus median AUC	0.7	0.9	2.0	-1.4	1.4	1.0	-0.3	-0.2	-0.0
Reaction time num false alarms	0.5	0.7	1.5	-0.3	0.2	-0.6	1.0	-1.2	-1.2
Reaction time num false alarms AUC	0.5	0.7	1.2	-1.1	0.9	0.1	0.6	-1.1	-1.0
Reaction time trials correct on left	0.3	0.5	0.9	-0.5	0.7	-0.1	0.5	-1.0	-0.9
Reaction time trials on left	0.4	0.6	1.2	-0.6	0.8	-0.0	0.5	-1.1	-1.0
Reaction time mean	0.2	0.3	0.6	-0.0	-0.1	0.4	-0.6	0.7	0.7
Reaction time mean AUC	0.2	0.3	0.7	0.1	-0.2	0.4	-0.6	0.9	0.8
Median of all reaction times	0.3	0.4	0.9	0.3	-0.4	0.3	-0.7	0.9	0.9
Reaction time omissions	0.9	1.2	2.7	-1.6	1.6	1.2	-0.5	-0.3	-0.1
Reaction time false alarm rate	0.2	0.3	0.5	-0.5	0.3	-0.1	0.5	-0.7	-0.7
Reaction time premature initiation rate	1.5	2.0	4.7	-2.2	2.0	1.6	-0.7	-0.5	-0.1
Reaction time premature initiations	2.0	2.8	6.6	-2.6	2.5	1.5	-0.3	-1.2	-0.8
Std. dev. reaction times	0.3	0.5	0.8	-0.8	0.6	0.9	-0.6	0.5	0.6
Reaction time trials completed	0.4	0.6	1.2	-0.6	0.8	-0.0	0.5	-1.1	-1.0
Reaction time trials AUC	0.3	0.4	0.8	-0.5	0.6	-0.0	0.4	-0.9	-0.8
Run reversals in cocaine runway, females	2.2	2.1	3.2	-1.2	1.2	1.8	-1.7	1.3	1.5
Run reversals in cocaine runway, males	0.7	0.6	1.2	-0.4	0.6	-0.5	0.9	-1.1	-1.1
Latency to leave start box in cocaine runway	0.8	0.9	1.7	0.2	-0.5	0.7	-1.1	1.3	1.3
Latency to leave start box in cocaine runway, F	0.6	0.6	1.2	-0.0	-0.2	0.7	-1.0	1.1	1.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.2	-0.3	0.0	-0.1	0.2	0.2
Std. dev. time between licks in bursts	0.9	1.1	2.2	-0.7	0.9	-0.3	1.1	-1.5	-1.4
Total sessions with >9 infusions	0.3	0.4	0.9	0.9	-0.8	-0.4	0.1	0.6	0.5
Short access day 1 total inactive lever presses	1.1	1.3	2.9	1.7	-1.6	-1.2	0.4	0.6	0.3
Short access day 10 total inactive lever presses	0.6	0.7	1.6	1.2	-1.3	-0.8	0.3	0.5	0.3
Short access day 1 total infusions	1.0	1.1	1.8	1.4	-1.2	-0.5	-0.3	1.3	1.1
Short access day 10 total infusions	2.0	2.2	4.9	0.7	-0.6	0.8	-1.5	2.2	2.2
Short access total infusions	0.7	0.8	1.8	0.7	-0.5	0.3	-0.7	1.3	1.3
Short access day 1 locomotion	1.1	1.2	1.9	1.4	-1.3	-0.3	-0.6	1.3	1.1
Short access day 10 total locomotion	0.6	0.7	1.2	0.8	-0.7	0.1	-0.9	1.1	1.0
Short access total locomotion	0.5	0.6	1.1	0.6	-0.6	0.2	-0.8	1.1	1.0
One hour access (0.3 mA shock)	3.7	4.4	10.7	3.3	-2.9	-2.3	1.0	0.8	0.3
Compulsive drug intake	2.2	2.2	4.9	-2.2	2.1	1.1	-0.0	-1.3	-1.0
One hour access (shock baseline)	4.7	5.5	13.0	3.6	-3.3	-2.7	1.2	0.8	0.3
Social response proportion	0.8	0.9	1.5	-0.9	0.8	1.2	-1.2	0.7	0.8
Social responses	0.2	0.2	0.4	-0.6	0.6	0.3	0.1	-0.5	-0.4
Social time	0.3	0.4	1.0	-0.9	1.0	0.7	-0.4	-0.1	0.1
Soleus weight	2.9	8.5	14.9	3.9	-3.6	-3.7	2.5	-0.9	-1.4
Bone: stiffness	2.2	3.4	5.1	-1.3	1.2	2.2	-2.3	1.8	2.0
Tibialis anterior weight	4.5	15.5	34.0	-5.6	5.8	2.5	0.6	-3.6	-2.8
Time to tail flick, vehicle, before self-admin	2.1	2.1	3.4	-0.6	0.6	1.6	-1.8	1.7	1.8
Time to tail flick, vehicle, after self-admin	1.7	1.8	3.3	-1.8	1.7	1.7	-1.2	0.3	0.5
Time to tail flick, test, before self-admin	1.4	1.3	2.6	0.1	-0.2	0.9	-1.4	1.6	1.6
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.3	0.3	0.2	-0.0	-0.2	-0.1
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	1.1	-1.1	1.0	0.6	-0.1	-0.5	-0.3
Delta time to tail flick, test, before/after SA	2.3	2.0	4.3	-0.9	0.9	-0.5	1.5	-2.1	-2.0
Tibia length	0.5	1.3	2.7	-0.3	0.5	-0.7	1.3	-1.7	-1.6
Ambulatory time before self-admin	0.2	0.2	0.4	-0.1	0.0	0.5	-0.6	0.6	0.6
Ambulatory time after self-admin	0.8	0.9	1.7	0.8	-0.8	0.2	-0.9	1.3	1.2
Bone: tissue strength	0.2	0.2	0.4	0.6	-0.5	-0.1	-0.3	0.6	0.5
Total heroin consumption	2.3	2.7	6.0	-2.5	2.4	1.8	-0.8	-0.5	-0.1
Bone: trabecular number	2.0	3.1	5.1	-0.6	0.4	1.9	-2.2	2.1	2.2
Bone: trabecular spacing	0.7	0.9	1.5	0.3	-0.3	-1.0	1.2	-1.1	-1.2
Bone: trabecular thickness	1.2	1.4	3.0	0.7	-0.8	0.5	-1.2	1.7	1.6
Bone: trabecular tissue density	4.1	5.7	9.6	3.0	-2.9	-3.1	2.3	-0.9	-1.3
Water consumed over 24 hours	0.7	0.8	1.4	-1.1	0.9	1.2	-1.1	0.4	0.6
Number of responses in last shaping day	0.4	0.4	0.6	0.8	-0.8	-0.8	0.6	-0.2	-0.3