Hub : Traits

Retroperitoneal fat weight

Tags: Physiology · Weight

Project: dissection

12 loci · 37 genes with independent associations · 229 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	133358665	134882883	2	1	9.56e-08	6.19e-07	4.55e-01	Idh2
2	1	149857704	156065975	46	5	9.15e-11	1.51e-09	1.00e+00	Alg8 Aamdc Fam168a ENSRNOG00000064417 Coa4
3	1	251351727	260518987	46	5	7.04e-51	1.94e-51	1.00e+00	Rab11fip2 Cacul1 Afap1l2 Hspa12a ENSRNOG00000065260
4	3	45415084	46813656	1	1	1.79e-07	1.23e-06	3.01e-01	Tank
5	3	88764368	94152740	37	7	6.40e-15	6.68e-14	1.00e+00	AABR07053185.1 Arl14ep Cd44 Pdhx Apip Caprin1 Tcp11l1
6	3	126323673	128707024	6	1	1.77e-10	4.41e-12	6.61e-04	AABR07054000.1
7	3	129554891	132898674	17	6	1.27e-20	2.31e-20	1.00e+00	Kif16b Pcsk2 Rrbp1 Sec23b Scp2d1 ENSRNOG00000067833
8	6	19271415	20658264	1	1	3.01e-07	1.35e-08	1.69e-03	Rasgrp3
9	6	20965724	29090273	70	7	2.44e-32	1.01e-32	1.00e+00	Dnajc27 Ncoa1 Pcare Dtnb Drc1 Rab10 Cenpo
10	7	110658552	112052634	1	1	2.88e-07	4.31e-08	8.15e-03	Nptxr
11	10	92666462	94065985	1	1	2.24e-07	1.27e-07	3.09e-25	Cep112
12	10	103916742	105312647	1	1	3.13e-07	3.41e-07	1.00e+00	Slc26a11

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	11.54	64	46	124.3	1	0.00e+00	Tasp1 Ndufaf5 Flrt3 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Kat14 Dzank1 Polr3f Rbbp9 Sec23b Dtd1 Pdzd8 Scp2d1 Rab11fip2 Fam204a Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Pnlip Hspa12a Eno4 Shtn1 Cep112 Nanos1 Dclre1a Zfp133 Mgme1 Otor Zfp950 Ces2c Sfxn4 Zdhhc6 Smim26 AABR07007032.1 Bbip1 Tcf7l2 AABR07054000.1 Ccdc186 Casp7 Ism1 ENSRNOG00000065260 ENSRNOG00000065957 ENSRNOG00000067833 ENSRNOG00000068145 ENSRNOG00000071003
BMI without tail	13.73	32	15	40.5	0.99	7.17e-115	Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Pdzd8 Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Tenm4 Grk5 Gab2 Alg8 Ndufc2 Ints4 Aamdc Clns1a Aqp11 Rsf1 Kctd21 Usp35 Nanos1 Otor Pak1 Zfp950 Ces2c Sfxn4 ENSRNOG00000065260 ENSRNOG00000067833 ENSRNOG00000068145
Body weight	11.57	82	62	167.6	0.99	0.00e+00	Adcy3 Ncoa1 Tasp1 Esf1 Ndufaf5 Flrt3 Kif16b Snrpb2 Pcsk2 Dstn Rrbp1 Kat14 Dzank1 Polr3f Rbbp9 Sec23b Dtd1 Pdzd8 Scp2d1 Rab11fip2 Fam204a Prlhr Cacul1 Dennd10 Prdx3 Tenm4 Grk5 Gab2 Xpnpep1 Alg8 Aamdc Add3 Efr3b Rbm20 Gpam Shoc2 Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Pnlip Hspa12a Eno4 Shtn1 Cep112 Kctd21 Usp35 Nanos1 Dclre1a Zfp133 Mgme1 Otor Pak1 Slc26a11 Zfp950 Mxi1 Ces2c Sfxn4 Zdhhc6 Smim26 AABR07007032.1 Bbip1 Tcf7l2 AABR07054000.1 Ccdc186 Casp7 Ism1 ENSRNOG00000065260 ENSRNOG00000065957 ENSRNOG00000067833 ENSRNOG00000068145 ENSRNOG00000071003 ENSRNOG00000071115
Epididymis fat weight	15.96	124	102	275.7	0.99	0.00e+00	Dnajc27 Adcy3 Ncoa1 Babam2 Tasp1 Spdya Ppp1cb Rbks Ndufaf5 Flrt3 Slc4a1ap Gpn1 Kif16b Snrpb2 Zfp513 Klhl29 Pcsk2 Dstn Rrbp1 Trim54 Slc30a3 Preb Rbbp9 Sec23b Alk Clip4 Pcare Mapre3 Dpysl5 Slc35f6 Pdzd8 Rab11fip2 Kcnk3 Fam204a Fam166c Prlhr Cacul1 Otof Dennd10 Hadhb Prdx3 Kif3c Grk5 Asxl2 Dtnb Efr3b Gpam Tectb Gucy2g Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Pnlip Hspa12a Eno4 Shtn1 Cep112 Hadha Drc1 Nanos1 ENSRNOG00000025388 Abhd1 Plb1 Dclre1a Togaram2 Cad Dnmt3a Ypel5 Snx17 Ppm1g Zfp133 Otor Zfp950 Mxi1 Ces2c Sfxn4 Zdhhc6 Zfp512 AABR07007032.1 Itsn2 Bbip1 Rab10 Fkbp1b Krtcap3 Garem2 Gckr Tcf7l2 Mpv17 Fam228b Cenpo Nrbp1 AABR07054000.1 AABR07063279.1 Ccdc186 Casp7 Gtf3c2 Slc5a6 AABR07063281.1 Ism1 ENSRNOG00000064012 ENSRNOG00000065260 ENSRNOG00000065542 ENSRNOG00000065957 ENSRNOG00000066171 ENSRNOG00000066665 ENSRNOG00000067189 ENSRNOG00000067745 ENSRNOG00000067833 ENSRNOG00000068145 ENSRNOG00000068245 Fosl2 ENSRNOG00000068533 Ubxn2a ENSRNOG00000069525 ENSRNOG00000069735 ENSRNOG00000071003
Heart weight	12.9	3	0	0	0	1.00e+00	Rbks Cacul1 Sfxn4
Left kidney weight	10.79	21	13	35.1	0.98	3.97e-39	Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Gucy2g Nptxr Acsl5 Nhlrc2 Nanos1 Zfp950 Ces2c Sfxn4 Tcf7l2 Casp7 ENSRNOG00000065260 ENSRNOG00000065957 ENSRNOG00000068145 ENSRNOG00000071003
Right kidney weight	9.4	31	15	40.5	0.97	1.32e-59	Rab11fip2 Prlhr Cacul1 Dennd10 Prdx3 Grk5 Gpam Gucy2g Nptxr Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Tdrd1 Afap1l2 Fhip2a Atrnl1 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 AABR07007032.1 Tcf7l2 Ccdc186 Casp7 ENSRNOG00000065260 ENSRNOG00000065957 ENSRNOG00000068145 ENSRNOG00000071003
Tail length	6.54	6	0	0	1	1.08e-06	Aamdc Fam168a Kctd21 Pak1 Slc26a11 ENSRNOG00000064417
Length with tail	5.41	6	0	0	0.94	5.35e-05	Kif16b Cacul1 Fam168a Otor Sfxn4 Arhgef17
Length without tail	8.23	5	0	0	0.94	4.59e-04	Cacul1 Acsl5 Habp2 Sfxn4 Casp7
Liver weight, left	10.78	1	0	0	0	1.00e+00	Cacul1
Liver weight, right	12.98	22	4	10.8	0.98	4.91e-33	Spdya Pcare Dpysl5 Rab11fip2 Prlhr Cacul1 Grk5 Gpam Tectb Acsl5 Habp2 Nhlrc2 Nanos1 Dclre1a Togaram2 Zfp950 Sfxn4 Zdhhc6 Bbip1 Tcf7l2 Casp7 ENSRNOG00000065260
Parametrial fat weight	13.69	80	42	113.5	0.98	0.00e+00	Dnajc27 Adcy3 Ncoa1 Kif16b Snrpb2 Klhl29 Pcsk2 Dstn Rrbp1 Kat14 Dzank1 Polr3f Rbbp9 Sec23b Dtd1 Dpysl5 Slc35f6 Pdzd8 Scp2d1 Rab11fip2 Kcnk3 Fam204a Fam166c Prlhr Cacul1 Otof Dennd10 Hadhb Prdx3 Kif3c Grk5 Asxl2 Dtnb Efr3b Gpam Tectb Acsl5 Habp2 Nrap Nhlrc2 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Pnlip Hspa12a Shtn1 Hadha Drc1 Nanos1 Dclre1a Dnmt3a Zfp133 Mgme1 Otor Zfp950 Ces2c Sfxn4 Zdhhc6 Smim26 Sf3b6 AABR07007032.1 Itsn2 Rab10 Fkbp1b Garem2 Tcf7l2 Fam228b Cenpo Casp7 ENSRNOG00000064012 ENSRNOG00000065260 ENSRNOG00000065542 ENSRNOG00000065957 ENSRNOG00000066171 ENSRNOG00000066665 ENSRNOG00000067833 ENSRNOG00000068145 Ubxn2a
Extensor digitorum longus weight	4.6	36	0	0	-1	0.00e+00	Babam2 Spdya Ppp1cb Rbks Slc4a1ap Gpn1 Zfp513 Trim54 Slc30a3 Preb Alk Clip4 Pcare Dpysl5 Drc1 ENSRNOG00000025388 Abhd1 Plb1 Togaram2 Cad Ypel5 Snx17 Ppm1g Krtcap3 Gckr Mpv17 Nrbp1 AABR07063279.1 Gtf3c2 Slc5a6 AABR07063281.1 ENSRNOG00000067189 ENSRNOG00000067745 ENSRNOG00000068245 ENSRNOG00000069525 ENSRNOG00000069735
Soleus weight	6.54	18	0	0	0.35	3.73e-02	Spdya Alk Gpam Acsl5 Habp2 Afap1l2 Fhip2a Trub1 Atrnl1 Eno4 Plb1 Togaram2 Zdhhc6 AABR07007032.1 Ccdc186 Casp7 ENSRNOG00000065957 ENSRNOG00000069735
Tibialis anterior weight	5.74	1	0	0	0	1.00e+00	Rasgrp3
Tibia length	7.24	9	0	0	0.99	2.70e-49	Tasp1 Esf1 Ndufaf5 Flrt3 Kif16b Otor Slc26a11 AABR07054000.1 Ism1
Delay discounting water rate 18 sec	13.6	2	0	0	-1	1.76e-04	Dtd1 Scp2d1
Condit. Reinf. lever presses	14.46	9	0	0	-1	1.91e-14	Myo7a Capn5 B3gnt6 Lrrc32 Emsy Ucp2 Tsku Acer3 Thap12
Pavlov. Cond. lever latency	14.82	13	0	0	1	5.19e-22	Aamdc Clns1a Myo7a Capn5 B3gnt6 Lrrc32 Emsy Ucp2 Tsku Acer3 Thap12 ENSRNOG00000064417 Coa4
Pavlov. Cond. change in total contacts	14.49	1	0	0	0	1.00e+00	Ucp2
Pavlov. Cond. index score	13.67	5	0	0	-1	7.83e-06	Aamdc Capn5 B3gnt6 Lrrc32 Ucp2
Pavlov. Cond. latency score	13.86	1	0	0	0	1.00e+00	B3gnt6
Pavlov. Cond. lever contacts	14.92	14	0	0	-1	8.35e-24	Aamdc Clns1a Myo7a Capn5 B3gnt6 Lrrc32 Emsy Ucp2 Mrpl48 Tsku Acer3 Thap12 ENSRNOG00000064417 Coa4
Pavlov. Cond. response bias	14.41	20	0	0	-1	2.14e-38	Aamdc Clns1a Myo7a Capn5 B3gnt6 Lrrc32 Emsy P4ha3 Ucp2 Dnajb13 Slco2b1 Mrpl48 Fam168a AC110837.1 Tsku Acer3 Thap12 ENSRNOG00000064417 Coa4 ENSRNOG00000070123
Conditioned reinforcement - inactives	16.44	10	1	2.7	1	3.91e-33	Hipk3 Cstf3 Eif3m Wt1 ENSRNOG00000013437 Rcn1 Ccdc73 Prrg4 Tcp11l1 ENSRNOG00000067112
Intermitt. access day 15 inactive lever presses	19.68	5	1	2.7	-0.98	4.77e-04	ENSRNOG00000025388 Mpv17 AABR07063279.1 Gtf3c2 AABR07063281.1
Progressive ratio test 1 inactive lever presses	18.6	1	0	0	0	1.00e+00	AABR07063281.1
Bone volume	10.63	1	0	0	0	1.00e+00	Sfxn4
Bone: cortical area	13.64	20	0	0	0.97	2.02e-39	Rab11fip2 Prlhr Cacul1 Dennd10 Grk5 Acsl5 Habp2 Nhlrc2 Afap1l2 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 AABR07007032.1 Tcf7l2 Casp7 ENSRNOG00000065260 ENSRNOG00000065957 ENSRNOG00000068145
Bone: cortical thickness	14.53	8	3	8.1	0.93	5.12e-09	Tasp1 Esf1 Ndufaf5 Rab11fip2 AABR07054000.1 Ism1 ENSRNOG00000065957 ENSRNOG00000068145
Bone: final force	11.07	4	0	0	1	1.79e-03	Rab11fip2 Cacul1 Grk5 Sfxn4
Bone: final moment	11.37	7	0	0	1	6.49e-14	Rab11fip2 Cacul1 Grk5 Nanos1 Zfp950 Sfxn4 ENSRNOG00000065260
Bone: maximum diameter	11.09	9	0	0	0.99	1.07e-19	Cacul1 Acsl5 Habp2 Nhlrc2 Afap1l2 Dclre1a AABR07007032.1 Tcf7l2 Casp7
Bone: maximum force	10.44	3	0	0	1	3.39e-05	Rab11fip2 Cacul1 Sfxn4
Bone: maximum moment	10.87	4	0	0	1	2.13e-07	Rab11fip2 Cacul1 Sfxn4 ENSRNOG00000065260
Bone: periosteal estimation	9.62	15	0	0	0.97	2.81e-21	Rab11fip2 Prlhr Cacul1 Grk5 Acsl5 Habp2 Nhlrc2 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 Tcf7l2 Casp7 ENSRNOG00000065260
Bone: periosteal perimeter	12.96	24	2	5.4	0.95	3.19e-58	Rab11fip2 Cacul1 Dennd10 Grk5 Acsl5 Habp2 Nrap Nhlrc2 Adrb1 Afap1l2 Fhip2a Trub1 Atrnl1 AABR07007068.1 Nanos1 Dclre1a Zfp950 Ces2c Sfxn4 AABR07007032.1 Tcf7l2 Ccdc186 Casp7 ENSRNOG00000065260
Bone: trabecular thickness	14.88	4	0	0	1	1.07e-09	Rab11fip2 Cacul1 Grk5 Sfxn4
Food seeking constrained by brief footshock	15.94	12	0	0	-1	1.87e-148	Adcy3 Hadhb Kif3c Asxl2 Dtnb Efr3b Hadha Drc1 Dnmt3a Rab10 Garem2 ENSRNOG00000065542

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	31	1.5	3.42
Adipose	alternative TSS	7	0.4	2.68
Adipose	gene expression	91	1.1	3.23
Adipose	isoform ratio	34	1.2	3.13
Adipose	intron excision ratio	21	0.7	2.96
Adipose	mRNA stability	37	1.1	3.27
BLA	alternative polyA	11	0.9	3.19
BLA	alternative TSS	11	1.3	3.69
BLA	gene expression	64	1.1	3.39
BLA	isoform ratio	19	1.1	3.02
BLA	intron excision ratio	36	1.2	3.31
BLA	mRNA stability	21	1	3.33
Brain	alternative polyA	18	0.9	3.31
Brain	alternative TSS	16	0.9	3.31
Brain	gene expression	96	1.1	3.28
Brain	isoform ratio	25	0.8	3.24
Brain	intron excision ratio	52	1	3.19
Brain	mRNA stability	50	1.1	3.39
Eye	alternative polyA	2	1.1	3.27
Eye	alternative TSS	4	1.7	3.91
Eye	gene expression	13	1.2	3.4
Eye	isoform ratio	5	1.4	2.9
Eye	intron excision ratio	4	0.7	2.67
Eye	mRNA stability	3	1.3	3.64
IL	alternative polyA	4	0.7	2.92
IL	alternative TSS	1	0.3	2.96
IL	gene expression	35	1	3.29
IL	isoform ratio	8	1	3.33
IL	intron excision ratio	17	1.8	3.63
IL	mRNA stability	18	1.6	3.54
LHb	alternative polyA	5	0.9	3.3
LHb	alternative TSS	3	0.9	3.08
LHb	gene expression	42	1.3	3.5
LHb	isoform ratio	10	1.3	3.44
LHb	intron excision ratio	22	2.1	3.59
LHb	mRNA stability	20	1.9	3.79
Liver	alternative polyA	17	1.1	3.17
Liver	alternative TSS	22	1.5	3.4
Liver	gene expression	73	1	3.27
Liver	isoform ratio	33	1.4	3.44
Liver	intron excision ratio	50	1.1	3.19
Liver	mRNA stability	29	1.2	3.38
NAcc	alternative polyA	12	0.9	3.22
NAcc	alternative TSS	10	1.1	3.44
NAcc	gene expression	77	1.2	3.45
NAcc	isoform ratio	23	1.2	3.5
NAcc	intron excision ratio	31	1	3.12
NAcc	mRNA stability	33	1.5	3.61
OFC	alternative polyA	13	2.2	4.19
OFC	alternative TSS	0	0	3.51
OFC	gene expression	53	1.4	3.44
OFC	isoform ratio	11	1.3	3.34
OFC	intron excision ratio	17	1.7	3.43
OFC	mRNA stability	24	2.2	4.03
PL	alternative polyA	8	0.6	3.06
PL	alternative TSS	5	0.4	3.34
PL	gene expression	78	1.1	3.38
PL	isoform ratio	18	0.8	3.2
PL	intron excision ratio	41	1.1	3.22
PL	mRNA stability	36	1.2	3.49