Hub : Traits

Retroperitoneal fat weight

Tags: Physiology · Weight

Project: dissection

14 loci · 49 genes with independent associations · 981 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	68147781	69546302	1	1	1.50e-07	6.38e-07	7.73e-04	Zfp579
2	chr1	132960860	135354292	4	1	5.89e-09	6.19e-07	6.51e-01	Hddc3
3	chr1	149199615	150594931	3	1	7.85e-09	1.02e-09	1.00e+00	Tenm4
4	chr1	150601120	156065975	138	4	1.16e-09	1.51e-09	NaN	Aamdc Fam168a LOC102550562 LOC120099893
5	chr1	206331763	207721987	1	1	1.41e-07	2.91e-06	5.40e-01	Syt7
6	chr1	251352172	260518987	158	8	5.31e-51	1.94e-51	NaN	Add3 Gfra1 Grk5 LOC102547573 LOC120100068 Sfxn4 Xpnpep1
7	chr3	44152620	46813656	2	1	6.94e-08	1.23e-06	4.03e-04	Ly75
8	chr3	49219564	50957463	3	1	1.62e-09	1.62e-07	1.05e-01	Scn3a
9	chr3	87782779	94152740	149	7	1.41e-16	6.68e-14	1.00e+00	Arl14ep Cd44 Elp4 LOC100362814 Mpped2 Them7
10	chr3	126160536	128707024	24	5	1.37e-10	4.41e-12	2.87e-32	Esf1 Flrt3 Macrod2 Tasp1
11	chr3	129261795	132900111	88	9	1.18e-20	2.31e-20	1.00e+00	Dstn LOC102550304 Rbbp9 Rrbp1 Scp2d1 Sec23b Smim26 Snrpb2
12	chr6	20938785	29167220	405	8	1.97e-32	1.01e-32	1.00e+00	Adcy3 Drc1 Fkbp1b Hadha LOC120103502 Mpv17 Ppp1cb Slc5a6
13	chr7	110779978	112404870	3	1	4.31e-08	4.31e-08	1.00e+00	Syngr1
14	chr20	53722628	54429288	2	1	1.33e-22	1.33e-02	1.00e+00	LOC103694460

Pleiotropic Associations

Trait	Chi2 ratio	# genes+	# genes++	% genes++	Corr	Corr P	Genes
BMI with tail	12.19	66	55	112.2	1	0.00e+00	Ablim1 Acsl5 Adrb1 Afap1l2 Atrnl1 Cacul1 Casp7 Ccdc186 Cd99 Ces2c Dclre1a Dennd10 Dstn Dtd1 Dzank1 Emx2os Eno4 Fam204a Fhip2a Flrt3 Gfra1 Gpam Grk5 Gucy2g Habp2 Hspa12a Kif16b LOC102547573 LOC102548513 LOC102550304 LOC102550729 LOC102551125 LOC103694460 LOC120100064 LOC120100065 LOC120100068 LOC120101717 LOC120101719 Macrod2 Nanos1 Ndufaf5 Nhlrc2 Nrap Otor Pcsk2 Plekhs1 Pnlip Polr3f Prdx3 Prlhr Rab11fip2 Rbbp9 Rrbp1 Scp2d1 Sec23b Sfxn4 Smim26 Snrpb2 Tasp1 Tcf7l2 Tectb Trub1 Vti1a Zdhhc6 Zfp133 Zfp950
BMI without tail	14.73	37	15	30.6	0.99	9.22e-173	Aamdc Alg8 Aqp11 B3gnt6 Cacul1 Ces2c Clns1a Dennd10 Dstn Emx2os Fam204a Gab2 Grk5 Hspa12a Ints4 Kif16b LOC102550562 LOC102550729 LOC120100068 LOC120101717 LOC120101719 Myo7a Nanos1 Nars2 Ndufc2 Otor Pcsk2 Prdx3 Prlhr Rab11fip2 Rrbp1 Sec23b Sfxn4 Snrpb2 Tenm4 Usp35 Zfp950
Body weight	12.1	85	70	142.9	1	0.00e+00	Aamdc Ablim1 Acsl5 Add3 Adrb1 Afap1l2 Alg8 Atrnl1 Bfsp1 Cacul1 Casp7 Ccdc186 Cd99 Ces2c Dclre1a Dennd10 Dstn Dtd1 Dzank1 Efr3b Emx2os Eno4 Esf1 Fam204a Fhip2a Flrt3 Gab2 Gfra1 Gpam Grk5 Gucy2g Habp2 Hspa12a Ism1 Kif16b LOC102547573 LOC102548513 LOC102550304 LOC102550729 LOC102551125 LOC102551352 LOC103694460 LOC120100058 LOC120100064 LOC120100065 LOC120100066 LOC120100068 LOC120101717 LOC120101719 Macrod2 Mxi1 Nanos1 Nars2 Ndufaf5 Nhlrc2 Nrap Otor Pcsk2 Plekhs1 Pnlip Polr3f Prdx3 Prlhr Rab11fip2 Rbbp9 Rrbp1 Scp2d1 Sec23b Sfxn4 Shoc2 Smc3 Smim26 Snrpb2 Sptlc3 Tasp1 Tcf7l2 Tectb Tenm4 Trub1 Usp35 Vti1a Xpnpep1 Zdhhc6 Zfp133 Zfp950
Epididymis fat weight	15.98	130	110	224.5	0.99	0.00e+00	Abhd1 Ablim1 Acsl5 Adcy3 Adrb1 Afap1l2 Agbl5 Alk Asxl2 Atraid Atrnl1 Babam2 Cacul1 Cad Casp7 Ccdc186 Cenpo Ces2c Cgref1 Clip4 Dclre1a Dennd10 Dnajc27 Dnmt3a Dpysl5 Drc1 Dstn Dtnb Efr3b Eif2b4 Emx2os Eno4 Fam204a Fam228b Fhip2a Fkbp1b Flrt3 Fndc4 Fosl2 Garem2 Gckr Gfra1 Gpam Gpn1 Grk5 Gtf3c2 Gucy2g Habp2 Hadha Hadhb Hspa12a Ift172 Ism1 Itsn2 Kcnk3 Kif16b Kif3c Klhl29 Krtcap3 Lbh LOC102547573 LOC102548513 LOC102548914 LOC102550729 LOC102551125 LOC103692581 LOC120100064 LOC120100065 LOC120100066 LOC120100068 LOC120101717 LOC120101719 LOC120103492 LOC120103499 LOC120103502 Macrod2 Mpv17 Mrpl33 Mxi1 Nanos1 Ncoa1 Ndufaf5 Nhlrc2 Nrap Nrbp1 Ost4 Otof Otor Pcare Pcsk2 Plb1 Plekhs1 Pnlip Ppm1g Ppp1cb Prdx3 Preb Prlhr Rab10 Rab11fip2 Rbbp9 Rbks RGD1565766 Rrbp1 Sec23b Sf3b6 Sfxn4 Slc30a3 Slc35f6 Slc4a1ap Slc5a6 Snrpb2 Snx17 Spdya Sptlc3 Supt7l Tasp1 Tcf7l2 Tectb Togaram2 Trim54 Trub1 Ubxn2a Vti1a Wdcp Ypel5 Zdhhc6 Zfp512 Zfp513 Zfp950
Heart weight	14.17	1	0	0	0	1.00e+00	Rbks
Left kidney weight	10.9	27	18	36.7	0.97	4.30e-70	Acsl5 Cacul1 Casp7 Cbx7 Cd99 Ces2c Dennd10 Emx2os Fam204a Gpam Grk5 Gucy2g Hspa12a LOC102550729 LOC103694460 LOC120100064 LOC120100068 Mgat3 Nanos1 Prdx3 Prlhr Rab11fip2 Sfxn4 Syngr1 Tcf7l2 Vti1a Zfp950
Right kidney weight	10.05	40	24	49	0.97	1.25e-85	Ablim1 Acsl5 Adrb1 Afap1l2 Atrnl1 Cacul1 Casp7 Cbx7 Ces2c Dclre1a Dennd10 Emx2os Fam204a Fhip2a Gpam Grk5 Gucy2g Habp2 Hspa12a LOC102547573 LOC102550729 LOC103694460 LOC120100064 LOC120100065 LOC120100066 LOC120100068 Mgat3 Nanos1 Nhlrc2 Nrap Plekhs1 Prdx3 Prlhr Rab11fip2 Sfxn4 Syngr1 Tcf7l2 Trub1 Vti1a Zfp950
Tail length	6.44	2	0	0	0	1.00e+00	Aamdc Gab2
Length with tail	5.32	4	0	0	0.99	4.32e-08	Aamdc Kif16b Otor Snrpb2
Length without tail	8.78	4	0	0	0.81	1.93e-01	Cacul1 Grk5 Ly75 Prlhr
Liver weight, right	13.85	18	6	12.2	0.98	7.11e-29	Cacul1 Casp7 Cd99 Clip4 Dennd10 Fam204a Grk5 Habp2 LOC103694460 Nanos1 Plekhs1 Prlhr Rab11fip2 Sfxn4 Spdya Togaram2 Vti1a Zfp950
Parametrial fat weight	14.1	87	47	95.9	0.98	0.00e+00	Ablim1 Acsl5 Adcy3 Afap1l2 Agbl5 Asxl2 Atrnl1 Bfsp1 Cacul1 Casp7 Ccdc186 Cenpo Ces2c Dclre1a Dennd10 Dnajc27 Dnmt3a Drc1 Dstn Dtd1 Dtnb Dzank1 Efr3b Emx2os Eno4 Fam204a Fam228b Fhip2a Fkbp1b Garem2 Gfra1 Gpam Grk5 Gucy2g Habp2 Hadha Hadhb Hspa12a Itsn2 Kcnk3 Kif16b Kif3c Klhl29 LOC102547573 LOC102550304 LOC102550729 LOC102551125 LOC103692581 LOC120100065 LOC120100068 LOC120101717 LOC120101719 LOC120103492 LOC120103499 LOC120103502 Nanos1 Ncoa1 Nhlrc2 Nrap Otof Otor Pcsk2 Plekhs1 Pnlip Polr3f Prdx3 Prlhr Rab10 Rab11fip2 Rbbp9 RGD1565766 Rrbp1 Scp2d1 Sec23b Sf3b6 Sfxn4 Slc35f6 Slc5a6 Smim26 Snrpb2 Tcf7l2 Trub1 Ubxn2a Wdcp Zdhhc6 Zfp133 Zfp950
Intraocular pressure	24.4	1	1	2	0	1.00e+00	LOC103694460
Extensor digitorum longus weight	4.84	32	0	0	-0.99	2.32e-315	Abhd1 Alk Atraid Babam2 Clip4 Eif2b4 Fndc4 Fosl2 Gpn1 Gtf3c2 Ift172 Krtcap3 LOC102548914 LOC103694460 Mpv17 Mrpl33 Nrbp1 Pcare Plb1 Ppp1cb Preb Rbks Slc4a1ap Slc5a6 Snx17 Spdya Supt7l Togaram2 Trim54 Ypel5 Zfp512 Zfp513
Soleus weight	6.55	13	0	0	0.38	2.15e-02	Ablim1 Acsl5 Alk Atrnl1 Fosl2 Gpam Grk5 Gucy2g LOC120100068 Tectb Togaram2 Trub1 Vti1a
Tibialis anterior weight	11.7	1	1	2	0	1.00e+00	LOC103694460
Tibia length	7.61	12	0	0	0.98	1.40e-30	Esf1 Flrt3 Ism1 Kif16b LOC102548513 LOC120101717 Macrod2 Ndufaf5 Otor Snrpb2 Sptlc3 Tasp1
Water consumed over 24 hours	19.18	1	0	0	0	1.00e+00	Ly75
Patch foraging indifference point 0 sec	12.96	1	0	0	0	1.00e+00	LOC103694460
Patch foraging total patch changes 0 sec	12.64	1	0	0	0	1.00e+00	LOC103694460
Patch foraging total patch changes 6 sec	13.11	1	0	0	0	1.00e+00	Gfra1
Patch foraging water rate 18 sec	13.57	3	0	0	-1	6.40e-05	Dtd1 Scp2d1 Smim26
Reaction time mean minus median AUC	17.14	1	0	0	0	1.00e+00	Ly75
Std. dev. reaction times	14.29	1	0	0	0	1.00e+00	Ly75
Condit. Reinf. active minus inactive responses	28.62	1	1	2	0	1.00e+00	Ly75
Condit. Reinf. active responses	24.88	1	1	2	0	1.00e+00	Ly75
Condit. Reinf. lever presses	15.07	9	0	0	-1	3.72e-20	B3gnt6 Capn5 Gdpd4 LOC102550562 Lrrc32 Myo7a Thap12 Tsku Wnt11
Condit. Reinf. lever reinforcers received	19.5	1	1	2	0	1.00e+00	Ly75
Pavlov. Cond. lever latency	15.82	11	0	0	1	1.63e-22	B3gnt6 Capn5 Fam168a Gdpd4 LOC100912071 LOC102550562 Lrrc32 Myo7a Thap12 Tsku Wnt11
Pavlov. Cond. change in total contacts	13.46	1	0	0	0	1.00e+00	Thap12
Pavlov. Cond. index score	14.76	4	0	0	-1	4.02e-04	LOC102550562 LOC103694460 Lrrc32 Thap12
Pavlov. Cond. latency score	14.82	1	0	0	0	1.00e+00	Thap12
Pavlov. Cond. lever contacts	16.16	11	0	0	-1	7.33e-23	B3gnt6 Capn5 Fam168a Gdpd4 LOC100912071 LOC102550562 Lrrc32 Myo7a Thap12 Tsku Wnt11
Pavlov. Cond. magazine entry number	20.26	1	0	0	0	1.00e+00	LOC103694460
Pavlov. Cond. response bias	15.81	14	0	0	-1	1.01e-27	B3gnt6 Capn5 Coa4 Dnajb13 Fam168a Gdpd4 LOC100912071 LOC102550562 Lrrc32 Map6 Myo7a Thap12 Tsku Wnt11
Conditioned reinforcement - inactives	17.21	6	0	0	1	1.04e-15	Ccdc73 Cstf3 Eif3m Rcn1 Tcp11l1 Wt1
Intermitt. access day 15 inactive lever presses	20.17	2	0	0	0.81	1.94e-01	Gpn1 Gtf3c2
Progressive ratio test 1 inactive lever presses	19.16	1	0	0	0	1.00e+00	Gtf3c2
Stereotopy head waving bouts, day 7	23.7	1	0	0	0	1.00e+00	Ly75
Stereotopy head waving duration, day 7	21.6	1	0	0	0	1.00e+00	Ly75
Degree of sensitization stereotypy	38.66	1	1	2	0	1.00e+00	Ly75
Condit. Reinf. active minus inactive responses	16.76	1	0	0	0	1.00e+00	Ly75
Incentive salience index mean	15.42	1	0	0	0	1.00e+00	Ly75
Total zone transitions, hab. session 2	19.52	1	0	0	0	1.00e+00	Ly75
Total locomotion distance, hab. session 2	24.97	1	1	2	0	1.00e+00	Ly75
Locomotion velocity, hab. session 2	19.99	1	1	2	0	1.00e+00	Ly75
Bone: apparent density	27.67	1	1	2	0	1.00e+00	Ly75
Bone surface	47.59	1	1	2	0	1.00e+00	Ly75
Bone volume	43.15	1	1	2	0	1.00e+00	Ly75
Bone: connectivity density	21.24	1	1	2	0	1.00e+00	Ly75
Bone: cortical apparent density	18.66	1	0	0	0	1.00e+00	Ly75
Bone: cortical area	13.69	26	0	0	0.96	8.11e-47	Ablim1 Acsl5 Afap1l2 Cacul1 Casp7 Ccdc186 Ces2c Dclre1a Dennd10 Emx2os Fam204a Fhip2a Gfra1 Grk5 Habp2 LOC102547573 LOC102550729 LOC120100065 LOC120100068 Ly75 Nhlrc2 Plekhs1 Prlhr Rab11fip2 Sfxn4 Zfp950
Bone: cortical porosity	16.96	1	0	0	0	1.00e+00	LOC103694460
Bone: cortical thickness	14.35	9	3	6.1	0.92	5.13e-10	Emx2os Esf1 LOC120100068 Macrod2 Ndufaf5 Prlhr Rab11fip2 Sptlc3 Tasp1
Bone: cortical tissue density	17.88	1	0	0	0	1.00e+00	Ly75
Bone: elastic work	15.82	1	0	0	0	1.00e+00	Ly75
Bone: endosteal estimation	9.05	1	0	0	0	1.00e+00	Ly75
Bone: endosteal perimeter	18.12	2	1	2	0	1.00e+00	Cd99 LOC103694460
Bone: final force	15	5	1	2	0.73	6.31e-02	Cacul1 Grk5 Ly75 Prlhr Zfp950
Bone: final moment	15.17	6	1	2	0.79	2.46e-03	Cacul1 Grk5 Ly75 Prlhr Sfxn4 Zfp950
Bone: marrow area	9.02	1	0	0	0	1.00e+00	Ly75
Bone: maximum diameter	11.29	17	1	2	0.99	2.83e-29	Ablim1 Acsl5 Afap1l2 Cacul1 Casp7 Ccdc186 Cd99 Dclre1a Fhip2a Gfra1 Habp2 LOC102547573 LOC103694460 LOC120100065 Nhlrc2 Nrap Plekhs1
Bone: maximum force	12.05	6	1	2	0.79	1.84e-02	Cacul1 Grk5 Ly75 Prlhr Sfxn4 Zfp950
Bone: maximum moment	13.5	6	1	2	0.76	1.82e-02	Cacul1 Grk5 Ly75 Prlhr Sfxn4 Zfp950
Bone: periosteal estimation	10.36	11	1	2	0.93	1.71e-09	Acsl5 Cacul1 Dennd10 Fam204a Grk5 Ly75 Plekhs1 Prlhr Rab11fip2 Sfxn4 Zfp950
Bone: periosteal perimeter	13.25	27	3	6.1	0.95	5.40e-79	Ablim1 Acsl5 Afap1l2 Atrnl1 Cacul1 Casp7 Ccdc186 Ces2c Dclre1a Dennd10 Fam204a Fhip2a Gfra1 Grk5 Habp2 LOC102547573 LOC102550729 LOC102551125 LOC103694460 LOC120100065 Nhlrc2 Nrap Plekhs1 Rab11fip2 Sfxn4 Trub1 Zfp950
Bone: trabecular number	35.45	1	1	2	0	1.00e+00	Ly75
Bone: trabecular spacing	60.24	1	1	2	0	1.00e+00	Ly75
Bone: trabecular thickness	19.05	4	1	2	0.8	5.06e-03	Cacul1 Ly75 Prlhr Sfxn4
Weight adjusted by age	20.87	1	0	0	0	1.00e+00	Ly75
Locomotion in novel chamber	34.01	1	1	2	0	1.00e+00	Ly75
Food seeking constrained by brief footshock	15.81	15	0	0	-1	2.68e-152	Adcy3 Asxl2 Dnajc27 Dnmt3a Drc1 Dtnb Efr3b Garem2 Hadha Hadhb Kif3c LOC120103492 Otof Rab10 RGD1565766
Run reversals in cocaine runway, females	21.72	1	0	0	0	1.00e+00	Ly75
Cu content in liver	31.36	2	1	2	0	1.00e+00	Cd99 LOC103694460
Fe content in liver	26.96	1	1	2	0	1.00e+00	LOC103694460
K content in liver	34.63	2	1	2	0	1.00e+00	Cd99 LOC103694460
Mn content in liver	32.26	1	1	2	0	1.00e+00	Ly75
Rb content in liver	55.75	2	2	4.1	0	1.00e+00	Cd99 LOC103694460
Sr content in liver	22.24	1	0	0	0	1.00e+00	LOC103694460

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	58	1.6	3.23
Adipose	alternative TSS	40	1.2	2.96
Adipose	gene expression	93	1	3.2
Adipose	isoform ratio	48	1	3.09
Adipose	intron excision ratio	21	0.7	2.84
Adipose	mRNA stability	47	1.1	3.18
BLA	alternative polyA	28	1.3	3.37
BLA	alternative TSS	16	0.8	3.53
BLA	gene expression	66	1	3.31
BLA	isoform ratio	35	1.2	3.49
BLA	intron excision ratio	34	1	3.2
BLA	mRNA stability	24	1	3.56
Brain	alternative polyA	43	1.2	3.26
Brain	alternative TSS	34	0.8	3.33
Brain	gene expression	97	1	3.31
Brain	isoform ratio	65	1.2	3.38
Brain	intron excision ratio	56	0.9	3.17
Brain	mRNA stability	63	1.2	3.44
Eye	alternative polyA	8	2.7	3.82
Eye	alternative TSS	1	0.3	2.85
Eye	gene expression	7	0.6	3
Eye	isoform ratio	4	0.7	2.95
Eye	intron excision ratio	7	0.8	2.71
Eye	mRNA stability	7	1.9	3.49
IL	alternative polyA	26	2.4	3.83
IL	alternative TSS	5	0.8	2.69
IL	gene expression	32	0.8	3.15
IL	isoform ratio	17	1.4	3.14
IL	intron excision ratio	15	1.3	3.32
IL	mRNA stability	25	1.8	3.91
LHb	alternative polyA	21	1.9	3.54
LHb	alternative TSS	2	0.3	2.92
LHb	gene expression	48	1.3	3.45
LHb	isoform ratio	17	1.3	3.25
LHb	intron excision ratio	16	1.4	3.05
LHb	mRNA stability	19	1.5	3.59
Liver	alternative polyA	33	1.3	3.13
Liver	alternative TSS	23	0.9	3.28
Liver	gene expression	70	0.9	3.13
Liver	isoform ratio	52	1.4	3.56
Liver	intron excision ratio	53	1.1	3.11
Liver	mRNA stability	40	1.3	3.35
NAcc	alternative polyA	37	1.2	3.31
NAcc	alternative TSS	24	0.9	3.26
NAcc	gene expression	91	1.1	3.38
NAcc	isoform ratio	44	1	3.29
NAcc	intron excision ratio	39	0.8	3.13
NAcc	mRNA stability	33	1	3.58
OFC	alternative polyA	28	2.5	4.01
OFC	alternative TSS	5	0.7	3.17
OFC	gene expression	38	0.9	3.16
OFC	isoform ratio	16	1.2	3.09
OFC	intron excision ratio	19	1.6	3.43
OFC	mRNA stability	27	2	3.85
PL	alternative polyA	44	1.3	3.37
PL	alternative TSS	21	0.6	3.18
PL	gene expression	89	1	3.3
PL	isoform ratio	53	1.1	3.42
PL	intron excision ratio	51	0.9	3.3
PL	mRNA stability	44	1.1	3.47
pVTA	alternative polyA	29	1.7	3.55
pVTA	alternative TSS	8	0.6	3.12
pVTA	gene expression	59	1.1	3.49
pVTA	isoform ratio	24	1.1	3.22
pVTA	intron excision ratio	25	0.8	3.07
pVTA	mRNA stability	16	1.1	3.53
RMTg	alternative polyA	13	2.2	3.58
RMTg	alternative TSS	6	1.3	3.53
RMTg	gene expression	19	1	3.36
RMTg	isoform ratio	8	1.2	3.15
RMTg	intron excision ratio	11	1.4	3.22
RMTg	mRNA stability	12	1.9	3.88