Slc15a3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Slc15a3	0.08	0.06	9.4e-05	0.06	0.05	0.06	0.05	3.2e-05	4.3e-05	2.4e-05	8.6e-05
2	Liver	gene expression	Slc15a3	0.05	0.03	1.9e-05	0.05	0.04	0.03	0.04	3.0e-06	1.3e-05	2.8e-04	1.8e-05
3	Adipose	gene expression	Slc15a3	0.19	0.08	2.4e-13	0.09	0.1	0.1	0.1	1.8e-10	3.1e-11	3.8e-11	3.0e-11
4	BLA	mRNA stability	Slc15a3	0.09	0.05	2.0e-03	0.07	0.04	0.01	0.05	1.7e-04	4.5e-03	6.7e-02	1.2e-03
5	NAcc	mRNA stability	Slc15a3	0.01	0.01	7.6e-03	0.01	0.01	0.01	0.01	1.5e-02	7.8e-03	5.3e-03	6.0e-03
6	NAcc	gene expression	Slc15a3	0.04	0.02	8.0e-07	0.05	0.05	0.04	0.05	1.2e-08	9.9e-08	4.7e-07	3.9e-08
7	Adipose	mRNA stability	Slc15a3	0.03	0.02	3.3e-03	0	0.01	0	0.01	9.5e-02	8.2e-03	2.5e-01	4.8e-02
8	OFC	gene expression	Slc15a3	0.16	0.1	8.6e-03	0.01	0.03	-0	0.02	1.4e-01	6.6e-02	4.5e-01	1.0e-01
9	Brain	mRNA stability	Slc15a3	0.1	0.05	3.4e-07	0.04	0.05	0.05	0.05	4.6e-05	1.5e-05	1.7e-05	4.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.1	0.3	1.0	-0.2	-0.5	0.3	-0.5	-0.3	-0.3	0.6	0.4	-1.0
Area under the delay curve	0.3	0.4	2.1	0.3	-0.0	-0.3	-1.5	0.3	0.3	0.4	0.5	-1.0
BMI with tail	3.1	10.9	19.2	-3.1	-3.5	3.5	-1.0	-3.4	-3.2	4.4	4.0	-2.6
BMI without tail	0.4	2.0	3.8	-1.2	-1.4	1.4	-0.8	-1.4	-1.3	1.9	1.9	-1.0
Body weight	2.9	12.9	23.6	-3.3	-3.8	3.9	-0.5	-3.7	-3.6	4.9	4.4	-2.4
Weight adjusted by age	1.2	3.4	4.8	-2.2	-1.8	1.8	1.4	-2.1	-2.1	1.8	2.2	0.3
Bone surface	0.6	1.3	2.5	-0.8	-1.2	0.9	-0.6	-1.1	-1.0	1.5	1.6	-1.1
Bone volume	0.3	0.6	1.3	-0.4	-0.7	0.6	-0.7	-0.6	-0.5	1.1	0.8	-1.1
Breakpoint value in progressive ratio session	1.5	2.8	4.6	-2.0	-1.7	1.8	2.1	-1.7	-1.7	1.2	1.3	1.1
Number of licking bursts	0.1	0.2	0.4	-0.1	-0.6	0.4	-0.5	-0.3	-0.2	0.6	0.3	-0.5
Context. condit. distance diff. score	0.1	0.1	0.4	-0.1	-0.1	0.1	-0.3	-0.2	-0.1	0.5	0.5	-0.6
Locomotion velocity, session 1	0.3	0.3	0.9	-0.7	-0.3	-0.0	0.9	-0.5	-0.5	-0.2	0.2	0.9
Locomotion distance, session 1	0.9	1.2	2.2	-1.5	-1.1	1.2	0.9	-1.4	-1.4	0.8	0.8	-0.1
Locomotion velocity, session 2	1.9	2.3	3.4	-1.8	-1.5	1.6	0.5	-1.8	-1.8	1.6	1.6	-0.8
Locomotion distance, session 2	0.7	1.0	1.9	-1.4	-1.1	1.1	0.9	-1.2	-1.3	0.7	0.6	-0.0
Locomotion velocity, session 3	1.3	1.5	5.0	-0.4	-0.7	0.5	-1.7	-0.7	-0.6	1.4	1.2	-2.2
Locomotion distance, session 3	0.4	0.5	1.2	0.7	0.5	-0.8	-1.1	0.8	0.8	-0.3	-0.4	-0.5
Stereotopy head waving bouts, day 3	0.3	0.4	1.8	-0.0	-0.1	-0.0	-1.0	-0.2	-0.2	0.5	0.4	-1.4
Stereotopy head waving duration, day 3	0.4	0.5	1.2	-0.3	-0.4	0.3	-0.8	-0.5	-0.5	0.9	0.9	-1.1
Locomotion velocity, session 7	0.3	0.3	1.4	0.3	0.2	-0.2	-1.1	0.1	0.2	0.4	0.4	-1.2
Locomotion distance, session 7	0.2	0.3	0.8	0.4	0.5	-0.5	-0.9	0.2	0.2	0.2	0.3	-0.9
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	-0.5	-0.6	0.3	0.2	-0.5	-0.4	0.4	0.7	0.1
Stereotopy head waving duration, day 7	0.6	0.8	1.4	-1.0	-1.1	0.8	0.2	-1.0	-0.9	1.0	1.2	-0.1
Locomotion velocity, session 8	0.1	0.2	0.5	0.4	0.6	-0.3	0.2	0.4	0.4	-0.2	-0.1	0.7
Locomotion distance, session 8	0.1	0.2	0.7	-0.2	-0.2	0.0	-0.4	-0.3	-0.3	0.5	0.4	-0.8
Degree of sensitization distance	1.0	1.0	1.7	-0.8	-0.7	0.9	-0.0	-1.2	-1.1	1.3	1.3	-1.1
Degree of sensitization stereotypy	0.9	1.0	1.7	-1.1	-1.2	0.8	0.6	-1.1	-1.1	1.0	1.3	0.3
Conditioned locomotion	0.4	0.5	1.3	-0.7	-0.7	0.3	-0.1	-0.8	-0.9	0.7	1.1	-0.3
Cocaine response after cond. corrected	0.1	0.2	0.3	-0.5	-0.4	0.2	0.4	-0.4	-0.5	0.3	0.5	0.1
Cocaine response after cond. not corrected	0.1	0.1	0.4	-0.5	-0.2	0.0	0.6	-0.4	-0.4	-0.1	0.2	0.2
Cocaine response before conditioning	0.2	0.2	0.7	-0.3	0.1	0.0	0.9	-0.0	0.0	-0.5	-0.6	0.5
Saline control response	1.3	1.8	2.8	-1.6	-1.5	1.7	1.2	-1.4	-1.4	1.2	1.2	0.6
Bone: connectivity density	0.8	1.2	2.0	-1.1	-1.4	1.1	-0.2	-1.1	-1.1	1.3	1.4	-0.9
Bone: cortical apparent density	0.1	0.2	0.6	-0.5	-0.2	0.2	0.8	-0.4	-0.5	-0.1	-0.1	0.3
Bone: cortical area	0.1	0.1	0.4	-0.3	-0.2	0.3	-0.0	-0.3	-0.3	0.2	-0.2	-0.6
Bone: cortical porosity	0.2	0.2	1.1	-0.2	-0.2	0.3	0.6	-0.1	-0.1	0.0	0.2	1.0
Bone: cortical porosity	0.2	0.3	1.1	-0.4	-0.2	0.4	0.7	-0.2	-0.3	0.2	0.4	1.1
Bone: cortical thickness	1.0	1.7	4.3	-1.6	-1.2	1.5	2.1	-1.3	-1.4	0.3	0.1	1.0
Bone: cortical thickness	0.1	0.1	0.3	-0.1	-0.0	-0.3	0.3	0.1	0.0	-0.5	-0.4	0.3
Bone: cortical tissue density	0.2	0.3	0.8	-0.7	-0.4	0.3	0.9	-0.6	-0.6	0.0	0.1	0.4
Condit. Reinf. active minus inactive responses	1.6	1.8	3.3	-1.8	-1.6	1.3	1.6	-1.6	-1.7	0.6	0.6	0.7
Condit. Reinf. active-inactive response ratio	1.9	2.0	5.0	-1.7	-1.4	1.1	2.2	-1.4	-1.5	0.1	0.3	1.6
Condit. Reinf. active responses	1.3	1.7	3.2	-1.8	-1.6	1.3	1.1	-1.7	-1.7	0.8	0.7	-0.2
Condit. Reinf. inactive responses	0.3	0.4	2.2	-0.2	-0.3	0.3	-0.7	-0.3	-0.3	0.5	0.1	-1.5
Incentive salience index mean	0.8	1.0	1.9	-1.4	-1.1	0.9	0.8	-1.4	-1.4	0.5	0.4	-0.3
Condit. Reinf. lever presses	0.2	0.3	1.5	-0.3	-0.1	0.2	-0.5	-0.5	-0.5	0.4	0.2	-1.2
Condit. Reinf. active minus inactive responses	0.2	0.3	0.8	-0.6	-0.9	0.2	0.9	-0.4	-0.5	-0.4	-0.2	0.4
Condit. Reinf. active-inactive response ratio	0.4	0.6	1.2	-0.6	-0.8	0.4	-0.4	-0.8	-0.7	1.1	1.1	-0.7
Condit. Reinf. active responses	0.2	0.4	1.0	-0.6	-0.9	0.3	1.0	-0.5	-0.5	-0.4	-0.3	0.5
Condit. Reinf. inactive responses	0.6	0.8	2.3	0.3	0.2	-0.4	1.0	0.6	0.6	-1.5	-1.5	1.0
Condit. Reinf. lever presses	0.9	1.4	2.5	-1.3	-1.6	1.5	0.4	-1.2	-1.2	1.2	1.0	-0.6
Condit. Reinf. lever reinforcers received	0.5	0.8	1.7	-1.0	-1.3	0.7	1.3	-0.9	-0.9	-0.0	0.1	0.6
Conditioned reinforcement - actives	0.0	0.2	0.8	-0.2	0.1	-0.3	0.7	0.0	0.0	-0.6	-0.1	0.9
Conditioned reinforcement - inactives	0.1	0.2	0.9	-0.3	-0.3	0.4	-0.4	-0.4	-0.4	0.6	0.3	-1.0
Conditioned locomotion	1.0	1.6	2.6	1.3	1.2	-1.4	-1.6	1.1	1.2	-1.0	-1.0	-1.3
Patch foraging indifference point 0 sec	0.1	0.3	0.9	-0.5	-0.5	0.9	0.3	-0.4	-0.5	0.5	0.2	-0.3
Patch foraging indifference point AUC	0.3	0.7	1.4	-1.0	-0.7	1.2	1.2	-1.0	-1.0	0.3	-0.1	0.1
Delay disc. indifference point, 0s delay	0.5	0.5	2.2	0.2	-0.1	-0.2	-1.5	-0.1	-0.1	0.8	0.9	-1.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.6	-0.1	-0.2	0.1	-0.7	-0.0	0.0	0.3	0.3	-0.5
Delay disc. indifference point, 2s delay	0.7	0.8	2.8	0.9	0.6	-0.8	-1.7	0.8	0.8	0.0	0.0	-1.0
Delay disc. indifference point, 24s delay	0.1	0.2	0.6	0.3	0.0	-0.3	-0.8	0.4	0.4	-0.1	-0.1	-0.7
Delay disc. indifference point, 4s delay	0.5	0.6	2.2	0.3	-0.2	-0.2	-1.5	0.2	0.2	0.6	0.6	-1.4
Delay disc. indifference point, 8s delay	0.5	0.8	2.2	1.0	0.8	-1.0	-1.5	0.9	0.9	-0.2	0.0	-0.6
Indifference point function ln k	0.5	1.5	2.7	1.6	1.3	-1.4	-1.6	1.4	1.4	-0.5	-0.5	-0.8
Indifference point function log k	0.5	1.5	2.7	1.6	1.3	-1.4	-1.6	1.4	1.4	-0.5	-0.5	-0.8
Patch foraging total patch changes 0 sec	0.1	0.2	0.7	-0.5	-0.4	0.8	0.5	-0.4	-0.5	0.3	0.0	-0.1
Patch foraging total patch changes 12 sec	3.4	4.5	7.3	-2.6	-2.3	2.7	2.1	-2.4	-2.4	1.7	1.5	0.3
Patch foraging total patch changes 18 sec	0.3	0.7	2.3	-0.9	-0.7	1.2	1.5	-0.7	-0.8	0.2	-0.1	0.6
Patch foraging total patch changes 24 sec	1.5	5.0	9.0	-2.4	-2.3	3.0	0.8	-2.5	-2.5	2.5	1.9	-1.3
Patch foraging total patch changes 6 sec	0.3	0.5	1.2	-0.6	-0.5	1.1	0.1	-0.6	-0.6	0.9	0.5	-0.7
Patch foraging time to switch 0 sec	0.2	0.8	2.4	-0.6	-0.6	0.7	-0.8	-0.8	-0.7	1.4	1.5	-0.6
Patch foraging water rate 0 sec	0.5	1.7	4.2	1.0	1.3	-1.1	0.6	1.4	1.3	-1.8	-2.1	0.3
Patch foraging water rate 12 sec	0.5	1.9	2.8	1.4	1.6	-1.3	-0.5	1.7	1.6	-1.4	-1.7	-0.1
Patch foraging water rate 18 sec	0.5	1.2	1.8	1.2	1.3	-0.8	-0.8	1.3	1.3	-0.8	-1.2	-0.7
Patch foraging water rate 24 sec	0.9	1.3	2.3	1.3	1.3	-1.2	-0.1	1.5	1.5	-1.1	-1.1	0.2
Patch foraging water rate 6 sec	1.1	1.6	2.7	1.3	1.4	-1.2	0.0	1.6	1.5	-1.4	-1.6	0.1
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	2.2	-0.2	-0.2	0.6	-0.6	-0.5	-0.4	0.5	0.1	-1.5
Distance traveled before self-admin	0.9	2.0	2.9	-1.5	-1.7	1.7	1.0	-1.4	-1.5	1.7	1.4	-0.4
Distance traveled after self-admin	0.4	0.8	1.6	-1.0	-1.3	1.1	1.0	-0.8	-0.8	0.6	0.4	0.2
Extensor digitorum longus weight	4.6	18.2	23.8	-4.7	-4.9	4.6	1.3	-4.9	-4.8	4.8	4.8	-1.4
Bone: elastic displacement	0.6	0.8	2.1	0.3	0.7	-0.9	1.0	0.5	0.4	-1.2	-0.9	1.5
Bone: elastic work	0.4	0.6	1.6	-0.8	-0.6	0.8	1.3	-0.7	-0.8	0.2	0.1	0.8
Bone: endosteal estimation	1.2	2.8	9.6	1.8	1.2	-1.3	-3.1	1.2	1.4	0.2	-0.3	-2.5
Bone: endosteal perimeter	1.5	3.7	11.3	2.1	1.7	-1.8	-3.4	1.5	1.7	-0.0	-0.3	-2.5
Epididymis fat weight	0.4	2.1	5.7	1.6	1.3	-1.1	-2.3	1.1	1.2	0.1	-0.7	-2.4
Delta time in closed arm before/after self-admin	1.9	1.7	2.8	-1.4	-1.5	1.7	0.8	-1.5	-1.5	1.4	1.1	-0.5
Delta time in open arm before/after self-admin	1.2	1.4	2.5	-1.6	-1.4	1.3	0.5	-1.5	-1.4	1.0	1.1	-0.1
Diff in mean of infusions in LGA sessions	1.4	2.5	3.8	-1.8	-1.7	1.9	1.2	-1.9	-1.8	1.5	1.4	0.3
Delay discount exponential model param	0.3	0.5	2.3	-0.4	-0.0	0.4	1.5	-0.3	-0.3	-0.3	-0.4	1.0
Extinction: sum of active levers before priming	1.2	1.8	2.9	-1.5	-1.3	1.4	0.1	-1.5	-1.4	1.7	1.6	-0.7
Active lever presses in extinction session 6	1.4	1.4	2.4	-1.5	-1.3	1.2	0.9	-1.4	-1.3	1.1	1.2	0.3
Bone: final force	0.4	0.7	1.0	-0.9	-0.7	1.0	0.1	-1.0	-1.0	0.9	0.6	-0.7
Bone: final moment	0.4	0.7	1.1	-0.9	-0.7	1.0	0.2	-1.0	-1.0	0.9	0.6	-0.6
Food consumed during 24 hour testing period	0.2	0.5	1.0	0.5	0.6	-0.6	0.4	0.7	0.7	-1.0	-0.9	0.7
Glucose	1.0	1.6	2.6	1.6	1.2	-1.4	-1.3	1.5	1.6	-0.8	-1.0	-0.8
Heart weight	0.9	1.5	6.9	0.8	0.5	-0.5	-2.6	0.2	0.3	0.9	0.8	-1.9
Delay discount hyperbolic model param	0.4	0.5	2.5	-0.5	-0.1	0.5	1.6	-0.4	-0.4	-0.3	-0.4	1.0
Intermittent access intake day 1-15 change	0.3	1.5	2.9	1.2	1.2	-1.2	-0.1	1.2	1.2	-1.6	-1.7	0.3
Intermittent access intake escalation	0.3	1.5	2.9	1.1	1.2	-1.3	0.0	1.2	1.2	-1.7	-1.7	0.4
Intermittent access intake escalation 2	0.2	0.3	1.0	0.5	0.6	-0.4	0.2	0.5	0.5	-0.7	-1.0	-0.0
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.1	0.2	0.3	-0.3	0.3	0.3	0.2	-0.3	-0.3	0.1
Intermitt. access day 15 inactive lever presses	0.3	1.9	4.8	-0.9	-0.9	1.4	-0.9	-1.2	-1.1	1.8	1.1	-2.2
Intermitt. access escalation Index	0.4	1.3	2.0	1.2	1.1	-1.4	-1.1	1.1	1.1	-1.2	-1.1	-0.8
Intermittent access day 1 total infusions	0.7	2.0	8.0	0.2	-0.2	-0.0	-2.7	-0.3	-0.2	1.1	0.9	-2.8
Intermittent access day 15 total infusions	1.0	2.4	4.7	1.6	1.4	-1.6	-2.2	1.4	1.4	-1.2	-1.3	-1.7
Intermittent access terminal intake (last 3 days)	0.5	0.9	4.2	0.5	0.3	-0.4	-1.8	0.2	0.3	0.1	-0.1	-2.1
Intermittent access total infusions	1.1	1.4	5.5	0.7	0.4	-0.7	-2.3	0.3	0.4	0.1	0.0	-2.3
Intermittent access day 1 locomotion	0.7	1.2	4.6	-0.2	-0.4	0.1	-2.0	-0.5	-0.5	0.9	0.9	-2.1
Intermittent access day 15 total locomotion	0.2	1.0	3.5	-0.4	-0.5	0.6	-1.2	-0.8	-0.7	1.1	0.8	-1.9
Intermittent access total locomotion	1.7	2.0	9.3	-0.1	-0.4	0.2	-2.5	-0.6	-0.5	1.1	0.8	-3.0
Intermittent access standard deviation	0.0	0.1	0.3	0.2	0.3	-0.3	0.3	0.3	0.3	-0.6	-0.5	0.4
Left kidney weight	0.3	2.3	10.5	1.3	0.7	-0.8	-3.2	0.9	1.0	0.7	0.2	-2.3
Right kidney weight	0.1	1.0	4.0	0.8	0.5	-0.6	-2.0	0.5	0.6	0.3	-0.0	-1.7
Cocaine induced anxiety	0.2	0.4	2.3	-0.5	-0.1	0.1	1.5	-0.4	-0.4	-0.1	0.2	1.0
Post-drug Anxiety	0.4	0.4	0.8	-0.6	-0.5	0.6	0.9	-0.7	-0.6	0.7	0.8	0.4
Baseline Anxiety	0.2	0.3	0.7	-0.1	-0.5	0.5	-0.7	-0.2	-0.2	0.7	0.4	-0.8
Tail length	0.1	0.3	1.2	-0.5	-0.5	0.6	1.1	-0.5	-0.5	0.2	0.1	0.6
Length with tail	0.7	3.0	5.0	-1.7	-1.9	2.1	0.8	-1.9	-1.9	2.2	1.9	-0.4
Length without tail	1.1	6.0	9.6	-2.6	-2.7	3.1	1.5	-2.6	-2.6	2.9	2.5	-0.5
Times rat made contact with spout	0.5	0.5	1.7	-0.7	-0.8	0.5	1.3	-0.5	-0.5	-0.2	-0.2	1.1
Lifetime Intake	0.9	1.1	4.7	0.5	0.3	-0.5	-2.2	0.2	0.2	0.3	0.3	-2.1
Liver weight, left	0.5	0.9	1.5	0.9	0.9	-1.2	-0.1	1.0	1.0	-1.2	-1.1	0.5
Liver weight, right	1.1	1.9	3.1	1.5	1.3	-1.8	-0.7	1.6	1.5	-1.5	-1.7	0.0
Locomotor activity	0.9	1.5	4.2	1.2	0.9	-0.6	0.5	1.4	1.4	-1.4	-2.0	0.5
Locomotor testing distance	0.5	1.3	3.8	1.0	1.0	-0.7	0.6	1.2	1.2	-1.5	-2.0	0.5
Locomotor testing rearing	0.3	1.2	3.3	0.7	0.8	-0.5	1.0	1.0	1.0	-1.4	-1.8	0.8
Locomotion in novel chamber	1.1	1.5	2.4	1.5	1.5	-1.3	-0.9	1.4	1.4	-0.9	-1.1	-0.4
Locomotion in novel chamber post-restriction	0.4	1.2	1.6	1.1	1.3	-1.2	-0.2	1.2	1.2	-1.3	-1.0	0.8
Fecal boli incidents, locomotor time 1	0.3	0.7	2.3	-0.7	-0.9	0.8	1.5	-0.8	-0.8	0.2	-0.1	0.7
Change in fecal boli incidents, locomotor task	2.4	2.6	4.1	2.0	1.8	-1.7	-2.0	1.8	1.9	-0.8	-0.8	-0.8
Time >=10cm from walls, locomotor time 1	0.3	0.4	0.9	0.6	0.4	-0.7	-1.0	0.5	0.6	-0.2	-0.2	-0.8
Bouts of movement, locomotor time 1	2.7	3.5	8.0	-1.9	-2.0	2.1	2.8	-1.8	-1.9	0.5	0.3	2.0
Total resting periods, locomotor time 1	2.1	2.4	5.4	-1.6	-1.7	1.7	2.3	-1.5	-1.6	0.4	0.2	1.7
Rest time, locomotor task time 1	0.2	0.4	0.6	0.8	0.7	-0.7	-0.5	0.4	0.4	-0.7	-0.7	0.4
Distance moved, locomotor task time 1	0.1	0.1	0.4	0.0	0.3	-0.4	-0.4	0.2	0.3	0.3	0.6	-0.6
Vertical activity count, locomotor time 1	0.3	2.1	3.5	1.5	1.8	-1.9	-1.1	1.7	1.7	-1.3	-1.0	-0.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	0.2	0.2	-0.4	0.6	0.3	0.3	-0.5	-0.3	0.6
Bouts of movement, locomotor time 2	1.8	5.9	8.6	-2.9	-2.6	2.8	2.6	-2.8	-2.9	1.8	1.8	0.7
Total resting periods, locomotor time 2	1.3	5.3	7.9	-2.8	-2.5	2.6	2.4	-2.7	-2.8	1.6	1.6	0.6
Rest time, locomotor task time 2	0.1	0.2	0.4	0.5	0.3	-0.6	-0.3	0.5	0.5	-0.6	-0.6	0.0
Distance moved, locomotor task time 2	0.2	0.2	0.6	0.2	0.6	-0.4	0.5	0.4	0.4	-0.3	0.1	0.8
Vertical activity count, locomotor time 2	0.7	1.7	2.7	1.3	1.6	-1.5	-0.2	1.6	1.5	-1.3	-1.0	1.0
Light reinforcement 1	0.1	0.3	0.9	0.2	0.3	-0.1	0.7	0.3	0.3	-0.8	-1.0	0.7
Light reinforcement 2	0.3	0.7	2.4	0.9	0.7	-0.4	-1.5	0.6	0.7	-0.0	-0.4	-1.2
Bone: marrow area	1.3	3.2	10.2	2.0	1.4	-1.4	-3.2	1.4	1.6	0.0	-0.4	-2.5
Bone: maximum diameter	0.3	0.5	2.3	0.3	0.1	-0.0	-1.4	0.0	0.1	0.5	0.1	-1.5
Bone: maximum force	1.0	1.9	3.2	-1.1	-1.1	1.4	-0.7	-1.5	-1.4	1.8	1.5	-1.6
Bone: maximum moment	0.9	1.8	3.0	-1.1	-1.1	1.4	-0.6	-1.5	-1.4	1.7	1.4	-1.6
Mean time between licks in bursts	0.1	0.4	1.1	-1.0	-0.3	-0.0	0.3	-1.0	-1.1	0.1	0.6	-0.1
Mean num. licks in bursts	0.2	0.6	1.8	-0.2	0.3	-0.3	1.3	0.1	0.1	-1.0	-0.7	1.3
Cd content in liver	0.7	0.8	1.4	0.9	1.0	-1.2	-0.1	0.9	0.9	-0.9	-0.6	0.8
Co content in liver	1.1	1.3	2.3	1.0	1.3	-1.3	0.5	1.0	1.0	-1.5	-1.3	1.1
Cu content in liver	0.2	0.2	0.4	0.6	0.7	-0.4	-0.4	0.5	0.5	-0.4	-0.5	-0.2
Fe content in liver	0.0	0.0	0.3	0.1	0.1	-0.1	-0.5	0.1	0.1	0.2	0.1	-0.2
K content in liver	0.2	0.2	1.0	-0.1	-0.3	0.1	-0.6	-0.3	-0.2	0.4	0.2	-1.0
Mg content in liver	0.1	0.1	0.3	0.1	0.0	0.1	-0.1	0.1	0.1	-0.1	-0.4	-0.6
Mn content in liver	1.7	1.9	3.0	-1.6	-1.7	1.2	0.3	-1.6	-1.6	1.4	1.6	-0.7
Na content in liver	0.1	0.2	0.4	-0.5	-0.5	0.1	0.7	-0.3	-0.4	-0.2	-0.1	0.4
Rb content in liver	1.8	2.1	3.5	1.6	1.8	-1.4	-0.4	1.6	1.6	-1.6	-1.9	0.1
Se content in liver	0.3	0.4	0.7	-0.3	-0.6	0.3	-0.7	-0.5	-0.5	0.8	0.7	-0.8
Sr content in liver	4.4	3.8	5.5	-2.4	-2.3	2.0	1.4	-2.3	-2.3	1.8	2.0	0.4
Zn content in liver	1.4	1.7	2.8	-1.6	-1.5	1.5	0.8	-1.7	-1.7	1.0	0.9	-0.3
Bone: minimum diameter	1.0	2.0	6.7	1.2	0.7	-1.0	-2.4	0.9	1.0	-0.1	-0.7	-2.6
Time in familiar zone, hab. session 1	0.1	0.1	0.5	-0.2	-0.3	0.7	0.2	-0.3	-0.2	0.2	-0.4	-0.5
Time in novel zone, hab. session 1	0.8	0.9	1.4	1.0	1.0	-1.2	-0.1	1.1	1.1	-1.0	-0.7	0.9
Total zone transitions, hab. session 1	0.2	0.3	0.8	-0.7	-0.4	0.5	0.9	-0.5	-0.5	0.0	0.2	0.6
Total locomotion distance, hab. session 1	0.2	0.3	0.4	-0.5	-0.5	0.5	-0.2	-0.6	-0.5	0.6	0.5	-0.5
Locomotion velocity, hab. session 1	0.5	0.7	1.0	-1.0	-0.9	0.9	0.3	-1.0	-1.0	0.8	0.7	-0.2
Time in familiar zone, hab. session 2	0.7	0.8	1.4	0.8	0.9	-0.8	0.3	0.9	0.9	-1.1	-1.0	1.2
Time in novel zone, hab. session 2	0.5	0.6	0.7	-0.8	-0.8	0.8	0.1	-0.8	-0.8	0.7	0.7	-0.9
Total zone transitions, hab. session 2	0.5	0.6	1.1	-1.1	-0.9	1.0	1.0	-0.9	-0.9	0.2	0.1	0.1
Total locomotion distance, hab. session 2	0.3	0.4	0.7	-0.8	-0.8	0.7	0.4	-0.7	-0.7	0.3	0.1	-0.4
Locomotion velocity, hab. session 2	0.2	0.2	0.4	-0.6	-0.6	0.5	0.1	-0.6	-0.6	0.3	0.0	-0.6
Novel to familiar place preference ratio	0.8	1.1	2.2	-0.8	-1.0	0.9	-0.5	-1.0	-0.9	1.4	1.5	-1.0
Novelty place preference	0.6	0.8	1.7	-0.6	-0.8	0.7	-0.7	-0.7	-0.7	1.2	1.3	-1.1
Time in novel zone, NPP test	1.0	1.3	2.6	-0.9	-1.1	1.1	-0.5	-1.0	-1.0	1.6	1.6	-1.0
Total zone transitions, NPP test	0.7	1.0	1.8	-1.3	-1.0	1.1	1.3	-1.1	-1.1	0.4	0.4	0.6
Total locomotion distance, NPP test	0.0	0.1	0.2	-0.4	-0.2	0.3	0.3	-0.3	-0.3	-0.1	-0.2	-0.1
Locomotion velocity, NPP test	0.1	0.1	0.4	-0.0	0.3	-0.2	0.2	0.1	0.1	-0.5	-0.6	-0.1
Intraocular pressure	0.1	0.1	0.7	-0.2	-0.3	-0.0	0.3	-0.3	-0.4	-0.2	0.1	0.8
Delta distance traveled before/after self-admin	0.2	0.3	0.8	0.3	0.3	-0.6	-0.3	0.4	0.5	-0.9	-0.6	0.5
Delta ambulatory time before/after self-admin	0.3	0.5	1.1	0.5	0.5	-0.7	0.1	0.6	0.6	-1.0	-0.7	1.0
Parametrial fat weight	3.1	7.4	22.0	2.9	2.4	-2.5	-4.7	2.2	2.4	-0.4	-0.9	-3.5
Pavlov. Cond. lever latency	0.1	0.1	0.4	0.4	0.0	-0.1	-0.2	0.5	0.5	-0.1	-0.0	0.6
Pavlov. Cond. magazine entry latency	0.6	0.7	1.3	-1.0	-0.8	0.8	0.4	-1.2	-1.1	0.8	0.9	-0.3
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	-0.5	-0.3	0.2	0.6	-0.7	-0.7	-0.1	-0.1	-0.2
Pavlov. Cond. index score	0.2	0.2	0.5	-0.6	-0.3	0.4	0.6	-0.7	-0.7	0.2	0.2	0.0
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.3	-0.0	0.2	0.4	-0.4	-0.4	0.1	-0.0	-0.1
Pavlov. Cond. lever contacts	0.0	0.1	0.3	-0.0	0.3	-0.2	-0.0	-0.2	-0.1	-0.1	-0.2	-0.5
Pavlov. Cond. magazine entry number	0.5	0.6	1.0	0.9	0.7	-0.7	-0.8	1.0	1.0	-0.5	-0.7	-0.4
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.5	-0.2	-0.0	0.4	1.2	0.1	0.1	-0.9	-1.2	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.6	-0.7	-0.3	0.4	0.7	-0.8	-0.8	0.2	0.2	-0.0
Pavlov. Cond. response bias	0.4	0.5	1.0	-0.9	-0.5	0.5	0.7	-1.0	-1.0	0.4	0.5	-0.1
Pavlov. Cond. lever latency	1.5	2.1	4.4	1.6	2.1	-1.9	-0.7	1.5	1.5	-1.3	-1.0	0.7
Pavlov. Cond. magazine entry latency	5.6	7.9	13.2	-3.3	-3.6	3.3	1.7	-3.2	-3.2	2.6	2.5	-0.3
Pavlov. Cond. change in total contacts	1.3	3.1	5.7	-2.1	-2.4	2.3	1.3	-2.0	-1.9	1.4	1.2	-0.2
Pavlov. Cond. index score	4.0	6.2	11.4	-2.8	-3.4	3.1	1.3	-2.7	-2.7	2.4	2.2	-0.6
Pavlov. Cond. latency score	3.6	5.8	10.6	-2.7	-3.3	2.9	1.1	-2.6	-2.6	2.4	2.1	-0.7
Pavlov. Cond. lever contacts	1.6	2.4	5.0	-1.8	-2.2	2.1	1.1	-1.6	-1.6	1.3	1.0	-0.4
Pavlov. Cond. magazine entry number	9.4	12.2	19.6	4.0	4.4	-4.0	-1.9	3.9	3.9	-3.5	-3.3	0.3
Pavlov. Cond. intertrial magazine entries	1.1	2.5	3.1	1.7	1.8	-1.7	-0.0	1.8	1.8	-1.8	-1.7	1.1
Pavlov. Cond. lever-magazine prob. diff.	4.4	6.7	12.1	-3.0	-3.5	3.2	1.4	-2.8	-2.8	2.5	2.2	-0.5
Pavlov. Cond. response bias	3.4	4.7	8.8	-2.5	-3.0	2.7	1.1	-2.4	-2.4	2.0	1.8	-0.6
Time in closed arm before self-admin	0.0	0.0	0.1	0.3	0.0	-0.3	-0.2	0.2	0.3	-0.1	-0.0	-0.2
Time in closed arm after self-admin	0.3	0.3	0.8	0.7	0.4	-0.4	-0.1	0.7	0.6	-0.5	-0.9	-0.1
Time in open arm before self-admin	1.7	2.1	3.0	1.6	1.7	-1.5	-0.8	1.7	1.6	-1.5	-1.5	0.2
Time in open arm after self-admin	0.0	0.0	0.2	-0.4	-0.1	0.1	0.1	-0.2	-0.1	-0.1	0.1	0.2
Bone: periosteal estimation	0.5	1.2	4.5	0.9	0.5	-0.5	-2.1	0.5	0.6	0.4	-0.2	-2.1
Bone: periosteal perimeter	0.1	0.3	1.0	0.5	0.3	-0.2	-1.0	0.3	0.3	0.1	-0.3	-1.0
Bone: post-yield work	1.0	1.8	6.5	1.0	0.5	-0.3	-2.5	0.5	0.6	0.8	0.4	-2.5
Progressive ratio test 1 active lever presses	0.1	0.2	1.1	0.2	0.1	-0.4	-1.1	0.1	0.1	-0.0	0.2	-0.8
Progressive ratio test 1 breakpoint	0.1	0.2	1.0	0.2	0.1	-0.4	-1.0	0.1	0.1	-0.0	0.3	-0.8
Progressive ratio test 1 inactive lever presses	0.9	2.3	3.3	-1.5	-1.5	1.6	0.1	-1.7	-1.7	1.8	1.7	-1.4
Progressive ratio test 2 active lever presses	0.4	0.5	2.0	0.6	0.4	-0.6	-1.2	0.4	0.4	-0.2	-0.3	-1.4
Progressive ratio test 2 breakpoint	0.4	0.5	2.3	0.5	0.4	-0.5	-1.3	0.3	0.3	-0.2	-0.2	-1.5
Progressive ratio test 2 inactive lever presses	0.1	0.5	2.8	0.2	0.2	0.0	-1.1	0.0	0.1	0.2	-0.2	-1.7
Incentive Sensitization - Responses	0.4	1.0	2.1	-0.8	-1.0	1.0	-0.1	-1.0	-1.0	1.2	1.1	-1.4
Incentive Sensitization - Breakpoint	0.4	0.9	2.6	-0.6	-0.8	0.9	-0.3	-0.9	-0.8	1.2	1.0	-1.6
Sum of active levers in priming session hrs 5-6	0.6	0.5	1.3	-1.0	-0.9	0.6	1.1	-0.6	-0.6	0.0	0.0	0.6
Progressive ratio	0.2	0.5	1.8	0.0	-0.1	-0.1	-1.2	-0.4	-0.3	0.7	0.8	-1.3
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.1	0.2	-0.2	-0.0	0.2	0.2	-0.3	-0.2	0.0
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	-0.0	0.0	0.2	0.5	0.3	0.1	-0.4	-0.5	0.5
Retroperitoneal fat weight	2.6	11.8	19.5	4.0	3.6	-3.7	-4.4	3.4	3.6	-1.8	-2.5	-3.0
Reaction time number correct	0.2	0.7	2.7	-0.5	-0.7	1.0	1.2	-0.2	-0.3	0.6	0.5	1.7
Reaction time mean minus median	0.2	1.1	2.6	-1.1	-0.8	0.6	1.3	-1.0	-1.0	0.5	0.9	1.6
Reaction time mean minus median AUC	0.2	1.3	5.9	-0.9	-0.7	0.4	1.9	-0.7	-0.7	-0.1	0.4	2.4
Reaction time num false alarms	0.3	0.5	1.2	0.7	0.4	-0.4	0.0	0.8	0.7	-0.9	-1.1	0.3
Reaction time num false alarms AUC	0.1	0.3	0.8	0.4	0.3	-0.3	0.3	0.6	0.5	-0.9	-0.9	0.5
Reaction time trials correct on left	0.2	0.7	2.7	-0.5	-0.7	1.0	1.2	-0.2	-0.3	0.6	0.5	1.7
Reaction time trials on left	0.2	0.8	3.2	-0.5	-0.7	1.0	1.3	-0.2	-0.3	0.6	0.5	1.8
Reaction time mean	0.2	0.4	1.8	-0.7	-0.5	-0.2	0.8	-0.6	-0.6	-0.3	0.2	1.3
Reaction time mean AUC	0.1	0.3	1.6	-0.4	-0.2	-0.5	0.7	-0.3	-0.4	-0.5	-0.1	1.3
Median of all reaction times	0.1	0.2	0.5	-0.6	-0.5	-0.2	0.3	-0.5	-0.6	-0.2	0.2	0.7
Reaction time omissions	0.3	0.6	2.0	-0.7	-0.8	0.5	1.1	-0.5	-0.5	0.1	0.3	1.4
Reaction time false alarm rate	0.5	0.6	1.2	0.7	0.7	-0.8	-0.6	0.7	0.7	-1.0	-1.1	-0.7
Reaction time premature initiation rate	1.6	2.5	4.9	-1.2	-1.0	1.3	-1.0	-1.5	-1.4	2.2	2.1	-2.0
Reaction time premature initiations	0.8	2.5	4.9	-1.6	-1.5	1.8	0.2	-1.6	-1.6	2.2	2.1	-0.5
Std. dev. reaction times	0.2	0.8	4.4	-0.4	-0.1	-0.3	1.4	-0.2	-0.3	-0.6	-0.1	2.1
Reaction time trials completed	0.2	0.8	3.2	-0.5	-0.7	1.0	1.3	-0.2	-0.3	0.6	0.5	1.8
Reaction time trials AUC	0.2	0.7	2.7	-0.5	-0.6	1.0	1.2	-0.2	-0.3	0.6	0.5	1.7
Run reversals in cocaine runway, females	0.5	0.6	2.0	0.1	-0.1	-0.0	-1.4	-0.1	-0.1	0.7	0.7	-1.4
Run reversals in cocaine runway, males	1.8	1.9	2.9	1.5	1.5	-1.7	-0.8	1.5	1.4	-1.7	-1.5	-0.1
Latency to leave start box in cocaine runway	1.1	1.5	5.1	1.2	0.9	-1.1	-2.3	0.9	0.9	-0.1	-0.2	-1.7
Latency to leave start box in cocaine runway, F	0.2	0.3	1.7	0.1	-0.2	-0.0	-0.9	-0.1	-0.0	0.3	0.2	-1.3
Latency to leave start box in cocaine runway, M	2.5	2.4	4.5	1.9	1.7	-1.9	-2.1	1.6	1.6	-0.9	-0.8	-0.6
Std. dev. time between licks in bursts	0.3	0.5	1.3	0.7	1.1	-1.1	-0.6	0.5	0.4	-0.8	-0.7	-0.4
Total sessions with >9 infusions	0.1	0.1	0.6	0.0	-0.0	-0.5	-0.7	0.0	0.0	0.0	0.5	-0.4
Short access day 1 total inactive lever presses	0.1	0.2	0.8	0.1	-0.1	-0.2	-0.6	0.0	0.1	0.2	0.2	-0.9
Short access day 10 total inactive lever presses	0.0	0.1	0.4	0.0	0.2	-0.1	0.4	0.2	0.1	-0.4	-0.4	0.6
Short access day 1 total infusions	0.3	0.5	1.0	0.8	0.6	-1.0	-1.0	0.7	0.7	-0.6	-0.3	-0.5
Short access day 10 total infusions	0.7	1.2	5.2	0.1	-0.1	-0.2	-2.3	-0.3	-0.2	0.7	0.8	-2.0
Short access total infusions	0.5	0.7	3.7	0.3	0.2	-0.5	-1.9	0.1	0.1	0.3	0.6	-1.5
Short access day 1 locomotion	0.1	0.1	0.5	0.2	0.0	-0.3	-0.7	0.2	0.2	-0.2	-0.2	-0.7
Short access day 10 total locomotion	0.3	1.3	2.8	-0.8	-0.8	0.5	-1.2	-1.1	-1.0	1.2	1.4	-1.7
Short access total locomotion	0.4	0.7	2.4	-0.4	-0.5	0.2	-1.2	-0.6	-0.6	0.7	0.8	-1.5
One hour access (0.3 mA shock)	0.9	1.1	3.8	0.8	0.7	-0.6	-1.8	0.5	0.6	-0.1	-0.4	-1.9
Compulsive drug intake	0.8	1.1	3.1	-1.0	-0.7	1.1	1.8	-0.8	-0.9	0.7	0.8	1.3
One hour access (shock baseline)	1.3	3.3	6.7	2.0	1.8	-1.8	-2.6	1.6	1.7	-1.3	-1.5	-1.8
Social response proportion	0.5	0.6	1.1	0.9	1.0	-0.7	-0.7	1.0	1.0	-0.6	-0.7	0.0
Social responses	0.5	0.7	1.3	0.6	0.7	-0.5	0.5	1.0	1.0	-1.1	-1.2	0.7
Social time	0.4	0.6	3.2	-0.0	0.2	0.2	1.2	0.2	0.2	-0.7	-0.5	1.8
Soleus weight	2.0	6.0	10.5	2.6	2.4	-2.3	-0.8	2.9	2.9	-2.9	-3.2	0.4
Bone: stiffness	0.1	0.3	0.9	-0.2	-0.2	0.5	-0.5	-0.4	-0.3	0.7	0.4	-0.9
Tibialis anterior weight	5.8	20.1	28.5	-5.3	-5.1	5.1	2.8	-5.2	-5.2	4.4	4.5	0.6
Time to tail flick, vehicle, before self-admin	0.4	0.5	1.1	-0.3	-0.6	0.2	-0.9	-0.4	-0.4	0.9	1.1	-0.9
Time to tail flick, vehicle, after self-admin	0.5	1.1	2.6	-0.9	-0.9	0.8	-0.1	-1.1	-1.2	1.5	1.6	-0.5
Time to tail flick, test, before self-admin	0.4	0.5	1.9	0.1	-0.1	0.2	-1.2	-0.1	-0.0	0.8	0.5	-1.4
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.1	0.1	-0.1	0.6	0.1	0.0	-0.3	-0.3	0.4
Delta time to tail flick, vehicle, before/after SA	0.5	0.6	1.0	-0.8	-0.8	0.9	0.7	-0.9	-1.0	0.6	0.6	0.3
Delta time to tail flick, test, before/after SA	0.6	0.7	3.1	-0.6	-0.2	0.2	1.8	-0.2	-0.3	-0.7	-0.6	1.3
Tibia length	0.5	1.5	2.9	-1.2	-1.3	1.5	0.2	-1.3	-1.2	1.7	1.4	-0.5
Ambulatory time before self-admin	0.4	1.2	1.8	-1.2	-1.3	1.3	0.8	-1.1	-1.1	1.2	0.9	-0.3
Ambulatory time after self-admin	0.1	0.2	0.6	-0.5	-0.8	0.7	0.2	-0.4	-0.4	0.4	0.1	-0.3
Bone: tissue strength	0.7	0.8	1.3	0.9	1.2	-0.9	-0.1	0.9	0.8	-1.1	-1.1	0.0
Total heroin consumption	3.5	4.2	7.0	-2.4	-2.0	2.2	2.6	-2.1	-2.1	1.6	1.8	1.2
Bone: trabecular number	0.6	1.1	1.9	-0.8	-1.2	0.8	-0.6	-0.9	-0.9	1.2	1.2	-1.4
Bone: trabecular spacing	0.7	1.0	3.3	0.1	0.4	-0.1	1.5	0.5	0.4	-1.3	-1.3	1.8
Bone: trabecular thickness	0.2	0.3	0.5	0.7	0.4	-0.2	-0.7	0.6	0.6	-0.1	-0.6	-0.7
Bone: trabecular tissue density	2.5	4.4	6.5	2.3	2.4	-2.1	-0.4	2.4	2.3	-2.3	-2.5	0.8
Water consumed over 24 hours	0.0	0.1	0.2	-0.3	-0.4	0.5	0.3	-0.3	-0.3	0.3	0.0	-0.1
Number of responses in last shaping day	0.2	0.3	0.6	-0.7	-0.8	0.4	0.3	-0.6	-0.7	0.3	0.6	0.1