Hub : Genes

Serpinf1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression Serpinf1 0.15 0.11 4.6e-03 0.12 0.07 0.04 0.09 6.9e-04 8.7e-03 3.6e-02 4.4e-03
2 Eye gene expression Serpinf1 0.31 0.19 5.6e-03 0.08 0.03 -0.02 0.04 2.6e-02 1.3e-01 7.3e-01 9.1e-02
3 Brain mRNA stability Serpinf1 0.04 0.03 2.6e-03 0.02 0.03 0.02 0.02 3.6e-03 1.8e-03 3.1e-03 2.3e-03
4 Liver gene expression Serpinf1 0.03 0.02 5.1e-03 0.01 0.01 0.01 0.01 8.0e-03 3.8e-02 4.6e-02 3.9e-02
5 pVTA gene expression Serpinf1 0.1 0.07 8.0e-06 0.05 0.04 0.05 0.06 6.8e-05 6.0e-04 7.0e-05 1.2e-05
6 Adipose gene expression Serpinf1 0.53 0.14 0.0e+00 0.35 0.39 0.39 0.39 8.1e-40 1.2e-45 2.4e-45 1.5e-45
7 Brain gene expression Serpinf1 0.22 0.09 0.0e+00 0.2 0.22 0.21 0.22 3.4e-18 3.2e-20 1.8e-19 3.2e-20
8 PL gene expression Serpinf1 0.08 0.06 6.5e-07 0.06 0.06 0.05 0.06 2.3e-07 1.5e-07 1.5e-06 5.6e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density2.84.89.0-3.0-2.8-2.52.7-1.8-1.5-0.9-1.2
Area under the delay curve1.31.52.81.41.21.3-1.71.20.91.20.8
BMI with tail0.72.64.4-1.9-2.1-1.92.1-1.0-1.2-1.1-1.0
BMI without tail0.30.81.5-0.8-1.2-0.51.20.50.70.81.0
Body weight0.62.56.0-0.7-1.10.00.81.61.82.52.3
Weight adjusted by age0.60.91.1-0.9-0.9-1.01.1-0.9-0.9-1.0-0.9
Bone surface3.05.59.2-3.0-3.0-2.72.7-1.9-1.9-1.2-1.6
Bone volume3.05.59.6-3.0-3.1-2.72.7-1.8-1.9-1.1-1.5
Breakpoint value in progressive ratio session0.20.20.6-0.7-0.8-0.40.30.20.30.30.5
Number of licking bursts0.60.92.40.80.70.8-1.61.30.41.20.5
Context. condit. distance diff. score0.80.91.6-1.3-1.1-1.01.3-1.0-0.5-0.7-0.4
Locomotion velocity, session 11.01.12.6-1.5-1.6-1.21.3-0.8-0.2-0.00.0
Locomotion distance, session 10.60.71.4-1.2-1.1-1.10.3-0.8-0.9-0.2-0.7
Locomotion velocity, session 20.50.61.2-1.0-1.1-0.90.6-0.7-0.6-0.2-0.4
Locomotion distance, session 21.31.93.1-1.8-1.7-1.71.1-1.4-1.3-0.6-1.1
Locomotion velocity, session 35.46.19.82.72.62.6-3.12.61.92.31.8
Locomotion distance, session 30.10.10.3-0.1-0.2-0.2-0.5-0.2-0.50.2-0.4
Stereotopy head waving bouts, day 30.40.51.00.60.20.5-0.40.80.81.00.8
Stereotopy head waving duration, day 30.20.20.80.50.10.3-0.90.60.00.50.1
Locomotion velocity, session 71.31.41.9-1.2-1.1-1.31.2-1.4-1.1-1.1-1.1
Locomotion distance, session 71.92.43.3-1.6-1.6-1.71.8-1.6-1.3-1.4-1.3
Stereotopy head waving bouts, day 70.30.41.3-0.9-1.1-0.7-0.20.2-0.20.60.1
Stereotopy head waving duration, day 70.60.72.3-1.2-1.5-1.10.1-0.1-0.70.3-0.3
Locomotion velocity, session 80.60.81.1-1.0-0.9-1.00.6-1.0-0.8-0.9-0.8
Locomotion distance, session 80.91.43.3-1.8-1.6-1.51.2-1.0-0.7-0.2-0.4
Degree of sensitization distance0.70.72.7-0.8-0.8-0.71.7-0.7-0.1-0.7-0.1
Degree of sensitization stereotypy0.40.51.5-1.1-1.2-0.80.2-0.1-0.30.3-0.0
Conditioned locomotion0.10.10.40.30.40.2-0.10.0-0.2-0.6-0.3
Cocaine response after cond. corrected0.10.10.20.1-0.10.20.3-0.10.50.20.5
Cocaine response after cond. not corrected0.10.10.2-0.3-0.4-0.10.5-0.10.30.20.4
Cocaine response before conditioning0.50.61.6-1.2-1.2-1.00.7-0.4-0.6-0.2-0.4
Saline control response0.40.51.0-0.9-1.0-0.90.0-0.3-0.9-0.1-0.7
Bone: connectivity density4.77.312.5-3.5-3.4-3.13.1-2.5-2.1-1.4-1.7
Bone: cortical apparent density0.20.30.70.10.2-0.1-0.4-0.5-0.6-0.8-0.8
Bone: cortical area1.52.33.81.91.91.7-1.51.41.21.01.0
Bone: cortical porosity0.00.00.1-0.3-0.3-0.20.3-0.00.10.00.1
Bone: cortical porosity0.10.10.10.20.20.2-0.10.30.30.20.3
Bone: cortical thickness6.010.014.03.63.73.5-3.52.92.82.42.5
Bone: cortical thickness2.22.63.11.61.71.7-1.31.51.81.61.6
Bone: cortical tissue density0.20.30.7-0.10.1-0.2-0.2-0.6-0.6-0.8-0.7
Condit. Reinf. active minus inactive responses0.70.71.20.80.70.8-0.61.10.90.90.9
Condit. Reinf. active-inactive response ratio4.85.16.12.12.12.3-1.92.52.42.32.3
Condit. Reinf. active responses0.20.30.6-0.5-0.6-0.50.8-0.3-0.4-0.6-0.3
Condit. Reinf. inactive responses6.27.610.1-2.5-2.5-2.82.7-2.8-2.8-3.2-2.8
Incentive salience index mean0.50.71.00.60.60.8-0.60.91.01.01.0
Condit. Reinf. lever presses0.20.20.8-0.1-0.10.20.20.10.80.60.9
Condit. Reinf. active minus inactive responses0.30.40.7-0.8-0.8-0.80.7-0.6-0.6-0.5-0.5
Condit. Reinf. active-inactive response ratio0.20.20.40.40.40.5-0.00.50.60.40.6
Condit. Reinf. active responses1.11.62.5-1.3-1.6-1.50.8-1.0-1.4-0.9-1.3
Condit. Reinf. inactive responses3.64.77.1-2.1-2.5-2.51.0-1.8-2.7-1.8-2.4
Condit. Reinf. lever presses0.30.41.1-0.1-0.5-0.5-0.3-0.2-1.0-0.9-1.1
Condit. Reinf. lever reinforcers received1.11.62.6-1.2-1.6-1.50.6-1.0-1.5-0.9-1.3
Conditioned reinforcement - actives1.83.03.5-1.9-1.7-1.81.8-1.9-1.6-1.6-1.5
Conditioned reinforcement - inactives0.30.40.5-0.7-0.7-0.70.6-0.7-0.6-0.4-0.5
Conditioned locomotion0.10.10.50.20.10.1-0.70.1-0.3-0.1-0.4
Patch foraging indifference point 0 sec0.20.40.6-0.7-0.6-0.70.8-0.7-0.6-0.5-0.6
Patch foraging indifference point AUC0.10.20.50.1-0.2-0.20.1-0.6-0.7-0.4-0.7
Delay disc. indifference point, 0s delay0.10.10.30.1-0.6-0.3-0.20.3-0.20.3-0.0
Delay disc. indifference point, 16s delay1.11.22.41.31.11.1-1.61.10.71.10.6
Delay disc. indifference point, 2s delay0.91.02.10.90.91.0-1.41.00.71.10.7
Delay disc. indifference point, 24s delay0.20.20.70.60.40.5-0.80.30.30.20.2
Delay disc. indifference point, 4s delay1.41.52.01.20.91.2-1.41.21.11.41.1
Delay disc. indifference point, 8s delay0.91.01.41.11.11.1-1.21.00.80.90.7
Indifference point function ln k0.30.51.0-1.0-0.8-0.90.7-0.9-0.5-0.5-0.4
Indifference point function log k0.30.51.0-1.0-0.8-0.90.7-0.9-0.5-0.5-0.4
Patch foraging total patch changes 0 sec0.30.60.9-0.9-0.8-0.80.9-0.8-0.7-0.7-0.7
Patch foraging total patch changes 12 sec0.40.50.60.80.60.8-0.30.70.60.80.6
Patch foraging total patch changes 18 sec0.91.42.61.10.71.1-1.41.31.01.61.0
Patch foraging total patch changes 24 sec0.20.40.80.70.70.7-0.90.60.30.60.3
Patch foraging total patch changes 6 sec0.20.30.7-0.2-0.2-0.40.1-0.4-0.8-0.6-0.8
Patch foraging time to switch 0 sec1.73.55.21.71.61.9-1.42.32.11.72.1
Patch foraging water rate 0 sec0.71.62.5-1.0-0.9-1.20.9-1.4-1.6-1.2-1.6
Patch foraging water rate 12 sec0.00.00.1-0.2-0.1-0.0-0.30.00.00.40.1
Patch foraging water rate 18 sec2.23.35.4-2.3-2.2-2.11.5-1.7-1.7-1.2-1.5
Patch foraging water rate 24 sec0.40.50.8-0.6-0.8-0.80.2-0.8-0.9-0.6-0.9
Patch foraging water rate 6 sec0.10.10.30.30.20.0-0.5-0.4-0.4-0.1-0.5
Seeking ratio, delayed vs. immediate footshock0.40.51.90.90.70.5-1.40.5-0.20.1-0.3
Distance traveled before self-admin2.22.95.82.02.11.8-2.41.60.91.30.7
Distance traveled after self-admin0.40.40.70.80.80.7-0.70.60.50.70.4
Extensor digitorum longus weight5.220.627.3-5.2-5.2-5.24.5-4.4-4.2-3.5-3.8
Bone: elastic displacement0.20.20.80.60.50.3-0.9-0.1-0.2-0.3-0.3
Bone: elastic work4.45.78.72.82.82.6-3.02.11.91.81.7
Bone: endosteal estimation0.30.71.5-0.7-1.1-0.81.2-0.5-0.8-0.3-0.7
Bone: endosteal perimeter1.73.65.0-1.7-1.9-1.92.2-1.7-1.9-1.8-1.9
Epididymis fat weight3.210.825.0-4.8-5.0-3.93.9-2.0-1.6-1.0-0.8
Delta time in closed arm before/after self-admin0.20.20.50.30.40.1-0.7-0.0-0.5-0.2-0.6
Delta time in open arm before/after self-admin0.30.30.9-0.8-1.0-0.60.5-0.2-0.00.00.2
Diff in mean of infusions in LGA sessions0.40.51.7-0.9-0.8-0.61.3-0.50.1-0.30.2
Delay discount exponential model param1.21.32.3-1.3-1.1-1.21.5-1.1-0.9-1.1-0.8
Extinction: sum of active levers before priming2.62.94.3-1.9-2.1-1.91.6-1.7-1.5-1.4-1.4
Active lever presses in extinction session 62.02.02.9-1.6-1.7-1.61.5-1.4-1.1-1.1-1.0
Bone: final force2.03.25.01.51.51.8-1.22.01.92.21.9
Bone: final moment1.52.43.61.31.41.5-1.11.71.61.91.6
Food consumed during 24 hour testing period0.20.30.7-0.4-0.8-0.50.8-0.6-0.2-0.4-0.2
Glucose2.64.06.82.62.42.2-2.61.81.31.41.0
Heart weight0.30.51.3-1.1-0.9-0.60.9-0.10.20.70.5
Delay discount hyperbolic model param1.61.72.8-1.4-1.3-1.41.7-1.3-1.0-1.3-1.0
Intermittent access intake day 1-15 change0.30.61.5-0.1-0.0-0.50.3-0.9-1.1-1.1-1.2
Intermittent access intake escalation0.40.71.7-0.2-0.2-0.60.4-1.0-1.2-1.2-1.3
Intermittent access intake escalation 20.50.51.30.00.1-0.30.1-0.8-1.0-1.1-1.2
Intermitt. access day 1 inactive lever presses0.10.51.31.11.20.6-0.3-0.2-0.3-0.3-0.6
Intermitt. access day 15 inactive lever presses0.30.61.10.80.80.2-0.5-0.5-0.8-0.9-1.1
Intermitt. access escalation Index0.71.02.30.40.30.70.11.01.41.41.5
Intermittent access day 1 total infusions0.00.10.30.1-0.10.0-0.50.30.0-0.00.0
Intermittent access day 15 total infusions0.71.01.6-0.7-0.9-0.90.5-0.9-1.2-1.3-1.2
Intermittent access terminal intake (last 3 days)1.01.41.6-1.1-1.3-1.20.9-1.1-1.2-1.3-1.2
Intermittent access total infusions0.40.40.8-0.4-0.7-0.60.2-0.5-0.8-0.9-0.8
Intermittent access day 1 locomotion0.50.61.20.70.40.7-1.10.90.60.80.6
Intermittent access day 15 total locomotion0.10.10.40.50.20.2-0.60.1-0.20.0-0.2
Intermittent access total locomotion0.10.10.10.2-0.2-0.1-0.4-0.1-0.3-0.2-0.3
Intermittent access standard deviation1.32.85.0-0.9-0.9-1.41.1-1.8-2.1-2.2-2.2
Left kidney weight3.214.719.03.73.33.8-3.64.23.84.43.8
Right kidney weight3.013.719.53.23.03.6-3.24.13.94.43.9
Cocaine induced anxiety0.10.10.20.10.1-0.0-0.5-0.2-0.3-0.3-0.4
Post-drug Anxiety0.10.10.2-0.3-0.1-0.1-0.10.00.40.40.5
Baseline Anxiety0.20.20.6-0.7-0.5-0.30.8-0.20.40.30.5
Tail length1.35.212.00.70.41.5-0.72.62.93.53.3
Length with tail1.87.917.41.20.92.1-1.43.13.64.23.9
Length without tail0.41.44.2-0.0-0.20.5-0.51.31.42.01.7
Times rat made contact with spout2.42.73.11.71.41.7-1.51.71.71.81.7
Lifetime Intake0.30.40.7-0.4-0.6-0.60.4-0.6-0.7-0.9-0.8
Liver weight, left1.62.67.0-0.4-0.40.50.91.42.32.22.6
Liver weight, right1.01.74.0-0.7-1.00.10.91.11.71.82.0
Locomotor activity0.00.00.1-0.3-0.3-0.20.00.1-0.10.10.0
Locomotor testing distance0.00.00.1-0.2-0.2-0.2-0.10.2-0.10.1-0.0
Locomotor testing rearing0.50.91.3-1.1-1.2-1.10.5-0.7-1.1-0.7-1.1
Locomotion in novel chamber0.91.23.30.20.2-0.4-0.3-1.0-1.6-1.6-1.8
Locomotion in novel chamber post-restriction0.60.91.2-0.8-0.8-1.00.9-1.1-1.1-1.0-1.1
Fecal boli incidents, locomotor time 10.10.10.2-0.10.20.2-0.20.30.20.50.3
Change in fecal boli incidents, locomotor task0.50.50.80.90.80.9-0.40.50.90.30.8
Time >=10cm from walls, locomotor time 10.40.40.7-0.3-0.2-0.60.8-0.8-0.6-0.8-0.5
Bouts of movement, locomotor time 10.10.10.4-0.1-0.3-0.20.6-0.4-0.1-0.5-0.2
Total resting periods, locomotor time 10.30.40.9-0.2-0.3-0.40.9-0.7-0.4-0.9-0.5
Rest time, locomotor task time 10.20.21.10.40.30.00.3-0.4-0.3-1.0-0.5
Distance moved, locomotor task time 10.10.10.2-0.4-0.4-0.30.4-0.2-0.20.2-0.2
Vertical activity count, locomotor time 10.30.71.3-1.1-1.1-1.00.9-0.6-0.7-0.4-0.6
Time >=10cm from walls, locomotor time 20.30.51.01.01.00.8-0.50.60.60.30.5
Bouts of movement, locomotor time 20.00.10.10.00.20.3-0.20.40.30.00.3
Total resting periods, locomotor time 20.00.00.1-0.3-0.2-0.00.10.10.1-0.20.0
Rest time, locomotor task time 20.40.51.3-0.4-0.2-0.60.9-0.9-0.6-1.1-0.6
Distance moved, locomotor task time 20.10.10.30.3-0.2-0.0-0.60.2-0.40.1-0.4
Vertical activity count, locomotor time 20.30.40.80.70.40.6-0.80.90.50.70.5
Light reinforcement 10.00.10.2-0.1-0.2-0.1-0.30.5-0.10.30.1
Light reinforcement 22.74.15.12.12.12.1-2.32.21.82.01.7
Bone: marrow area0.30.61.4-0.7-1.1-0.81.2-0.5-0.7-0.2-0.7
Bone: maximum diameter0.30.61.3-0.4-0.4-0.60.9-0.7-0.9-1.1-1.0
Bone: maximum force1.83.24.41.61.61.8-1.52.01.82.11.8
Bone: maximum moment1.32.33.01.41.51.6-1.41.61.51.71.5
Mean time between licks in bursts0.20.61.80.20.20.4-0.60.80.91.31.0
Mean num. licks in bursts0.20.30.70.40.40.50.6-0.10.90.00.7
Cd content in liver1.82.03.0-1.1-1.2-1.41.0-1.6-1.5-1.7-1.6
Co content in liver0.10.10.30.40.50.3-0.30.00.20.00.2
Cu content in liver0.60.71.21.11.01.0-0.90.80.60.20.5
Fe content in liver0.30.41.00.20.20.40.10.80.90.61.0
K content in liver1.61.52.60.70.81.0-0.91.61.41.61.5
Mg content in liver0.20.20.2-0.4-0.4-0.50.4-0.2-0.5-0.4-0.4
Mn content in liver1.21.31.6-1.0-1.0-1.11.2-1.2-1.2-1.3-1.2
Na content in liver3.43.64.22.01.92.0-2.02.01.71.91.6
Rb content in liver4.35.06.1-2.4-2.4-2.42.5-2.1-2.1-2.0-1.9
Se content in liver0.50.61.11.10.90.8-0.60.70.60.70.6
Sr content in liver2.52.22.8-1.4-1.3-1.51.7-1.7-1.3-1.6-1.3
Zn content in liver0.10.10.2-0.1-0.1-0.00.5-0.10.40.10.4
Bone: minimum diameter1.11.92.51.51.41.5-1.01.61.41.31.3
Time in familiar zone, hab. session 13.33.24.4-1.8-1.3-1.71.3-2.1-1.9-2.1-1.9
Time in novel zone, hab. session 12.92.94.21.81.21.6-1.31.91.82.01.8
Total zone transitions, hab. session 12.13.04.4-2.0-2.1-2.01.0-1.3-2.1-1.0-1.9
Total locomotion distance, hab. session 10.50.71.3-1.1-1.1-1.10.3-0.5-1.00.1-0.8
Locomotion velocity, hab. session 10.71.01.8-1.3-1.2-1.20.6-0.8-1.2-0.2-1.0
Time in familiar zone, hab. session 21.81.93.0-1.7-1.7-1.70.8-1.3-1.5-0.7-1.3
Time in novel zone, hab. session 24.74.87.22.72.62.6-1.72.12.21.42.0
Total zone transitions, hab. session 20.50.71.6-1.2-1.3-1.10.3-0.3-0.80.1-0.5
Total locomotion distance, hab. session 20.10.10.7-0.3-0.2-0.1-0.10.30.00.80.2
Locomotion velocity, hab. session 20.10.10.6-0.2-0.1-0.1-0.10.30.00.80.1
Novel to familiar place preference ratio0.40.41.6-0.00.1-0.30.7-0.7-0.6-1.2-0.8
Novelty place preference0.20.20.80.10.2-0.10.7-0.4-0.3-0.9-0.4
Time in novel zone, NPP test0.20.20.7-0.2-0.1-0.30.8-0.4-0.3-0.9-0.4
Total zone transitions, NPP test1.01.52.7-1.6-1.6-1.60.2-0.8-1.5-0.2-1.2
Total locomotion distance, NPP test0.40.51.2-0.8-0.7-0.8-0.4-0.4-1.10.3-0.9
Locomotion velocity, NPP test0.30.41.2-0.4-0.4-0.6-0.5-0.4-1.1-0.0-1.0
Intraocular pressure1.21.73.4-0.7-0.5-1.10.2-1.3-1.8-1.8-1.9
Delta distance traveled before/after self-admin1.21.33.0-1.3-1.4-1.21.7-1.0-0.4-0.7-0.3
Delta ambulatory time before/after self-admin1.11.43.1-1.3-1.4-1.21.8-1.2-0.5-0.9-0.4
Parametrial fat weight2.86.715.2-3.6-3.9-3.03.5-1.6-0.9-0.6-0.3
Pavlov. Cond. lever latency0.70.81.4-0.9-0.8-0.90.4-1.0-1.2-0.8-1.2
Pavlov. Cond. magazine entry latency0.20.30.90.10.10.30.90.20.70.20.7
Pavlov. Cond. change in total contacts0.80.81.51.20.91.0-0.80.90.90.60.8
Pavlov. Cond. index score0.30.41.10.30.30.50.40.51.00.51.0
Pavlov. Cond. latency score0.70.82.00.60.50.80.20.91.40.91.4
Pavlov. Cond. lever contacts0.60.71.20.80.70.8-0.30.81.10.61.1
Pavlov. Cond. magazine entry number0.10.10.70.10.10.0-0.80.2-0.20.3-0.2
Pavlov. Cond. intertrial magazine entries0.70.91.9-0.9-1.0-1.00.0-0.5-1.4-0.8-1.2
Pavlov. Cond. lever-magazine prob. diff.0.20.30.70.20.20.40.40.40.80.30.8
Pavlov. Cond. response bias0.10.10.50.0-0.00.10.70.10.50.00.5
Pavlov. Cond. lever latency0.71.02.4-1.3-1.1-1.01.5-1.1-0.4-0.6-0.3
Pavlov. Cond. magazine entry latency2.53.04.41.51.61.7-2.02.11.51.81.5
Pavlov. Cond. change in total contacts0.91.52.71.31.21.2-1.61.40.81.10.7
Pavlov. Cond. index score1.41.94.21.61.41.4-2.01.60.71.00.6
Pavlov. Cond. latency score1.52.04.71.61.51.4-2.21.60.71.00.6
Pavlov. Cond. lever contacts0.71.01.91.10.91.0-1.41.30.70.80.6
Pavlov. Cond. magazine entry number2.32.84.2-1.6-1.6-1.72.0-2.0-1.4-1.7-1.4
Pavlov. Cond. intertrial magazine entries2.23.34.5-2.0-2.1-2.01.9-1.8-1.6-1.5-1.5
Pavlov. Cond. lever-magazine prob. diff.1.31.73.61.51.41.3-1.91.50.71.00.6
Pavlov. Cond. response bias1.42.03.11.51.41.4-1.81.71.11.21.0
Time in closed arm before self-admin0.40.51.1-0.9-1.0-0.61.1-0.20.30.50.5
Time in closed arm after self-admin0.40.40.60.80.80.7-0.70.60.60.70.5
Time in open arm before self-admin1.92.14.42.02.11.7-1.81.00.80.60.5
Time in open arm after self-admin0.10.20.40.70.60.4-0.50.10.0-0.1-0.1
Bone: periosteal estimation0.20.50.70.90.60.7-0.30.80.60.80.5
Bone: periosteal perimeter0.00.10.10.20.1-0.00.3-0.1-0.3-0.3-0.4
Bone: post-yield work0.10.20.6-0.4-0.4-0.20.70.10.20.30.4
Progressive ratio test 1 active lever presses0.10.10.3-0.0-0.2-0.1-0.50.0-0.4-0.5-0.4
Progressive ratio test 1 breakpoint0.10.10.3-0.1-0.3-0.2-0.4-0.0-0.5-0.6-0.5
Progressive ratio test 1 inactive lever presses0.30.51.31.11.10.7-0.90.2-0.1-0.0-0.3
Progressive ratio test 2 active lever presses1.51.82.6-1.0-1.2-1.30.9-1.4-1.5-1.6-1.6
Progressive ratio test 2 breakpoint1.61.92.6-1.1-1.3-1.31.0-1.4-1.5-1.6-1.6
Progressive ratio test 2 inactive lever presses0.40.61.4-0.1-0.1-0.50.1-1.0-1.1-1.1-1.2
Incentive Sensitization - Responses1.62.23.1-1.2-1.3-1.51.3-1.8-1.7-1.6-1.6
Incentive Sensitization - Breakpoint1.62.02.8-1.1-1.2-1.41.3-1.7-1.5-1.5-1.5
Sum of active levers in priming session hrs 5-60.70.71.8-1.2-1.2-0.81.3-0.50.0-0.20.2
Progressive ratio0.20.30.9-0.3-0.2-0.40.1-0.5-0.8-0.9-0.8
Food seeking constrained by brief footshock0.00.00.00.10.10.0-0.2-0.0-0.10.2-0.1
Seeking ratio, punishment vs. effort1.11.62.51.21.11.2-1.11.21.21.61.2
Retroperitoneal fat weight0.10.20.8-0.5-0.9-0.50.40.4-0.10.60.2
Reaction time number correct0.00.00.1-0.3-0.3-0.20.10.2-0.00.20.1
Reaction time mean minus median0.20.51.2-0.1-0.3-0.50.3-0.7-0.8-1.1-0.9
Reaction time mean minus median AUC0.92.43.0-1.3-1.4-1.61.2-1.6-1.7-1.7-1.7
Reaction time num false alarms1.01.42.8-0.9-0.8-1.10.4-1.0-1.7-1.2-1.7
Reaction time num false alarms AUC0.81.22.5-0.8-0.7-1.10.4-0.9-1.6-1.2-1.6
Reaction time trials correct on left0.00.00.1-0.3-0.3-0.20.10.2-0.00.20.1
Reaction time trials on left0.00.00.1-0.4-0.3-0.20.10.1-0.10.10.0
Reaction time mean0.00.00.20.20.20.10.2-0.2-0.1-0.4-0.2
Reaction time mean AUC0.10.10.40.30.30.10.1-0.3-0.2-0.7-0.4
Median of all reaction times0.10.10.20.40.50.4-0.10.10.3-0.00.2
Reaction time omissions0.10.10.2-0.2-0.3-0.30.4-0.4-0.2-0.2-0.2
Reaction time false alarm rate0.81.12.2-0.7-0.6-1.00.4-1.0-1.4-1.2-1.5
Reaction time premature initiation rate0.70.91.3-1.0-1.0-1.01.0-1.1-0.9-0.8-0.8
Reaction time premature initiations0.61.11.5-1.2-1.2-1.21.0-1.1-1.0-0.7-0.9
Std. dev. reaction times0.30.61.4-0.3-0.3-0.60.8-0.9-0.9-1.2-0.9
Reaction time trials completed0.00.00.1-0.4-0.3-0.20.10.1-0.10.10.0
Reaction time trials AUC0.00.00.1-0.3-0.3-0.20.10.1-0.10.10.0
Run reversals in cocaine runway, females0.60.61.3-0.4-0.3-0.6-0.2-0.8-1.1-0.9-1.1
Run reversals in cocaine runway, males1.41.41.8-1.0-0.9-1.21.1-1.2-1.3-1.2-1.3
Latency to leave start box in cocaine runway0.20.20.30.50.40.5-0.30.50.50.50.5
Latency to leave start box in cocaine runway, F0.40.40.70.40.40.6-0.30.70.80.80.9
Latency to leave start box in cocaine runway, M0.00.00.00.1-0.00.0-0.0-0.0-0.1-0.2-0.2
Std. dev. time between licks in bursts0.20.30.7-0.8-0.6-0.60.4-0.4-0.6-0.4-0.5
Total sessions with >9 infusions0.40.50.8-0.4-0.7-0.60.5-0.7-0.8-0.9-0.9
Short access day 1 total inactive lever presses0.10.10.3-0.3-0.4-0.30.5-0.4-0.2-0.2-0.2
Short access day 10 total inactive lever presses0.10.31.00.91.00.7-0.40.20.20.20.1
Short access day 1 total infusions0.20.30.80.2-0.0-0.20.1-0.6-0.7-0.9-0.9
Short access day 10 total infusions0.30.40.9-0.1-0.5-0.50.2-0.5-0.9-0.9-0.9
Short access total infusions0.20.20.50.2-0.2-0.1-0.1-0.3-0.6-0.7-0.7
Short access day 1 locomotion0.30.41.10.80.70.7-1.00.3-0.0-0.1-0.2
Short access day 10 total locomotion0.10.20.60.80.50.5-0.40.2-0.1-0.0-0.3
Short access total locomotion0.30.41.11.00.60.6-0.90.3-0.2-0.1-0.4
One hour access (0.3 mA shock)1.61.82.3-1.4-1.4-1.41.2-1.2-1.4-1.5-1.3
Compulsive drug intake0.20.20.5-0.4-0.4-0.00.60.30.60.50.7
One hour access (shock baseline)0.20.30.6-0.3-0.4-0.50.1-0.4-0.8-0.8-0.8
Social response proportion0.40.41.1-0.7-0.6-0.10.80.20.90.51.1
Social responses0.40.51.3-1.1-1.1-0.71.1-0.20.10.00.3
Social time0.91.32.8-1.6-1.5-1.21.7-0.7-0.4-0.6-0.2
Soleus weight0.92.56.2-2.5-2.5-1.72.0-0.6-0.00.60.4
Bone: stiffness0.30.51.2-0.4-0.4-0.00.60.60.71.11.0
Tibialis anterior weight7.525.637.5-6.1-6.0-5.85.5-4.7-4.2-3.8-3.6
Time to tail flick, vehicle, before self-admin4.84.98.1-2.8-2.8-2.62.5-2.0-1.6-1.5-1.3
Time to tail flick, vehicle, after self-admin0.20.30.5-0.7-0.7-0.70.4-0.4-0.4-0.5-0.4
Time to tail flick, test, before self-admin0.20.20.6-0.7-0.6-0.50.8-0.3-0.00.20.1
Time to tail flick, test, after self-admin0.30.30.50.60.50.6-0.30.50.70.50.6
Delta time to tail flick, vehicle, before/after SA0.40.41.10.91.00.7-0.90.30.10.0-0.0
Delta time to tail flick, test, before/after SA0.10.10.20.40.20.1-0.2-0.3-0.3-0.5-0.5
Tibia length1.33.66.01.31.41.8-0.92.02.42.32.5
Ambulatory time before self-admin3.55.37.92.52.62.5-2.82.31.72.11.5
Ambulatory time after self-admin1.11.31.81.01.01.1-0.81.21.31.31.3
Bone: tissue strength2.42.43.41.71.71.7-1.81.61.31.21.2
Total heroin consumption1.82.14.2-2.1-2.0-1.71.9-1.0-0.6-0.9-0.3
Bone: trabecular number3.25.410.1-3.2-3.0-2.72.6-2.0-1.7-1.1-1.4
Bone: trabecular spacing0.30.41.01.00.80.7-0.80.50.30.10.2
Bone: trabecular thickness0.30.40.8-0.9-0.8-0.70.8-0.4-0.40.1-0.3
Bone: trabecular tissue density1.52.13.81.81.91.7-1.91.31.00.80.8
Water consumed over 24 hours1.52.03.11.21.01.4-1.11.51.61.81.6
Number of responses in last shaping day0.30.30.90.80.70.5-0.90.1-0.3-0.2-0.4