Tmc7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Tmc7	0.17	0.08	3.6e-12	0.08	0.1	0.09	0.09	6.7e-08	3.0e-09	1.6e-08	1.4e-08
2	NAcc	intron excision ratio	chr1_172883314_172886548	0.04	0.03	4.6e-05	0.03	0.03	0.03	0.03	3.2e-04	2.5e-04	6.0e-04	2.6e-04
3	NAcc	gene expression	Tmc7	0.12	0.06	3.0e-14	0.1	0.11	0.1	0.11	1.2e-11	2.4e-12	4.6e-12	2.7e-12
4	pVTA	gene expression	Tmc7	0.21	0.1	1.6e-07	0.16	0.18	0.17	0.17	2.9e-07	3.9e-08	6.1e-08	5.6e-08
5	pVTA	intron excision ratio	chr1_172883314_172886548	0.08	0.05	2.0e-03	0.05	0.02	0.03	0.02	3.7e-03	5.1e-02	1.7e-02	4.2e-02
6	PL	gene expression	Tmc7	0.29	0.11	0.0e+00	0.2	0.22	0.22	0.23	2.3e-21	7.2e-24	6.0e-24	1.6e-24
7	Brain	intron excision ratio	chr1_172883314_172886548	0.06	0.04	1.7e-03	0.03	0.01	0.02	0.02	6.9e-04	1.5e-02	1.0e-02	4.8e-03
8	BLA	gene expression	Tmc7	0.19	0.1	5.7e-07	0.15	0.08	0.07	0.1	3.1e-08	6.1e-05	1.3e-04	4.2e-06
9	Brain	mRNA stability	Tmc7	0.04	0.03	5.5e-03	-0	0	-0	-0	4.7e-01	2.6e-01	6.1e-01	3.8e-01
10	IL	gene expression	Tmc7	0.27	0.13	5.7e-04	0.08	0.1	0.1	0.11	4.7e-03	1.8e-03	1.8e-03	1.2e-03
11	OFC	gene expression	Tmc7	0.37	0.15	1.3e-05	0.18	0.13	0.1	0.15	4.0e-05	5.4e-04	2.0e-03	2.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	1.0	1.7	2.5	1.3	-1.4	1.1	1.4	1.6	1.3	1.2	-1.0	1.4	1.1	-1.3
Area under the delay curve	0.5	0.6	0.9	-0.7	0.6	-0.8	-0.7	-0.5	-0.9	-1.0	0.8	-0.2	-0.9	0.7
BMI with tail	3.7	12.0	14.7	3.7	-3.4	3.6	3.6	3.2	3.8	3.8	-3.7	2.5	3.8	-2.8
BMI without tail	10.2	21.0	25.0	4.9	-4.6	4.7	4.8	4.4	5.0	4.8	-4.8	3.5	4.9	-4.0
Body weight	2.7	11.2	13.0	3.6	-3.5	3.4	3.6	3.3	3.5	3.2	-3.3	3.0	3.3	-2.7
Weight adjusted by age	0.8	0.9	2.1	0.9	-0.5	1.0	0.8	0.5	1.3	1.3	-1.2	-0.3	1.4	-0.2
Bone surface	1.0	1.8	2.3	1.4	-1.5	1.5	1.3	1.4	1.2	1.4	-1.3	1.3	1.0	-1.3
Bone volume	1.7	2.9	3.7	1.8	-1.9	1.7	1.7	1.9	1.5	1.6	-1.5	1.8	1.3	-1.7
Breakpoint value in progressive ratio session	1.5	1.6	2.7	-1.3	1.6	-1.6	-0.9	-1.4	-0.9	-1.2	1.1	-1.4	-0.7	1.5
Number of licking bursts	7.0	8.2	10.9	-3.1	2.8	-2.6	-3.3	-2.8	-3.2	-2.9	2.9	-2.4	-3.2	2.0
Context. condit. distance diff. score	0.3	0.3	0.7	-0.5	0.7	-0.6	-0.5	-0.7	-0.3	-0.2	0.3	-0.8	-0.1	0.8
Locomotion velocity, session 1	0.1	0.1	0.4	-0.1	-0.1	-0.1	-0.2	0.0	-0.5	-0.2	0.4	0.4	-0.6	-0.1
Locomotion distance, session 1	0.9	1.2	1.8	1.2	-1.1	1.0	1.3	0.9	1.1	1.2	-1.1	1.0	1.1	-0.8
Locomotion velocity, session 2	0.4	0.5	1.1	-0.6	0.4	-0.6	-0.6	-0.4	-1.0	-0.9	0.8	0.0	-1.1	0.4
Locomotion distance, session 2	1.7	2.4	3.8	1.6	-1.8	1.6	1.6	1.6	1.2	1.4	-1.4	1.7	1.0	-1.9
Locomotion velocity, session 3	0.2	0.3	0.4	0.6	-0.6	0.6	0.6	0.4	0.3	0.5	-0.6	0.6	0.3	-0.5
Locomotion distance, session 3	0.2	0.2	0.7	0.4	-0.6	0.8	0.1	0.4	0.2	0.6	-0.6	0.2	0.1	-0.3
Stereotopy head waving bouts, day 3	0.5	0.6	1.0	-0.7	0.9	-1.0	-0.5	-0.8	-0.6	-0.8	0.8	-0.7	-0.5	0.9
Stereotopy head waving duration, day 3	0.3	0.3	0.6	-0.5	0.7	-0.8	-0.3	-0.5	-0.4	-0.6	0.5	-0.5	-0.3	0.7
Locomotion velocity, session 7	1.4	1.5	2.6	1.2	-1.3	1.6	0.9	1.1	1.0	1.3	-1.4	0.7	0.9	-1.6
Locomotion distance, session 7	0.1	0.1	0.2	0.0	-0.2	0.5	-0.3	0.1	-0.2	0.2	-0.2	-0.1	-0.3	-0.4
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	0.5	-0.4	0.2	0.7	0.3	0.3	0.3	-0.4	0.5	0.3	-0.6
Stereotopy head waving duration, day 7	1.8	2.2	2.8	1.6	-1.5	1.4	1.7	1.2	1.5	1.5	-1.6	1.2	1.5	-1.5
Locomotion velocity, session 8	0.0	0.0	0.1	0.0	-0.1	-0.1	0.1	0.0	-0.2	-0.1	0.1	0.2	-0.2	-0.1
Locomotion distance, session 8	0.2	0.3	0.5	0.6	-0.6	0.6	0.6	0.4	0.5	0.7	-0.6	0.4	0.5	-0.6
Degree of sensitization distance	0.2	0.2	0.6	-0.3	0.4	-0.7	-0.1	-0.1	-0.2	-0.5	0.6	0.0	-0.2	0.2
Degree of sensitization stereotypy	1.3	1.5	2.0	1.3	-1.4	1.2	1.3	1.0	1.0	1.1	-1.2	1.2	1.0	-1.4
Conditioned locomotion	0.4	0.4	1.2	-0.7	0.6	-0.2	-0.9	-0.9	-0.6	-0.2	0.2	-1.1	-0.5	0.5
Cocaine response after cond. corrected	0.3	0.4	0.5	-0.6	0.6	-0.6	-0.7	-0.6	-0.7	-0.6	0.6	-0.4	-0.7	0.3
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.2	-0.3	0.3	0.1	0.3	0.1	0.2	-0.2	0.2	0.1	-0.5
Cocaine response before conditioning	2.5	3.1	4.3	1.8	-1.9	2.0	1.6	2.1	1.8	1.6	-1.7	1.6	1.5	-1.6
Saline control response	0.0	0.0	0.1	-0.2	0.3	-0.4	-0.0	-0.2	0.1	-0.2	0.1	-0.3	0.2	0.2
Bone: connectivity density	0.7	1.1	1.5	1.1	-1.0	1.1	1.0	1.1	1.1	1.2	-1.0	0.7	1.1	-1.0
Bone: cortical apparent density	0.8	1.0	1.5	-1.1	1.0	-1.0	-1.1	-0.6	-1.0	-1.2	1.1	-0.7	-1.0	1.2
Bone: cortical area	3.3	5.0	6.4	2.4	-2.5	2.3	2.3	2.5	2.0	2.0	-2.0	2.5	1.7	-2.3
Bone: cortical porosity	1.4	1.5	2.4	1.2	-1.0	1.1	1.3	0.8	1.5	1.2	-1.3	0.6	1.6	-1.4
Bone: cortical porosity	0.6	0.7	1.7	0.8	-0.5	0.7	0.9	0.3	1.1	0.9	-0.9	0.1	1.3	-0.9
Bone: cortical thickness	1.1	1.9	4.5	1.4	-1.6	1.2	1.4	1.7	0.8	0.7	-0.8	2.1	0.5	-1.8
Bone: cortical thickness	0.4	0.4	1.8	0.1	-0.4	-0.2	0.2	0.8	-0.4	-0.7	0.7	1.3	-0.7	-0.7
Bone: cortical tissue density	0.8	1.1	1.5	-1.1	1.0	-1.0	-1.1	-0.6	-1.0	-1.2	1.1	-0.7	-1.0	1.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.2	0.3	-0.3	-0.0	-0.0	0.3	0.0	0.1	-0.4	0.4	0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	1.0	0.2	0.0	0.2	0.3	0.3	0.9	0.5	-0.4	-0.4	1.0	0.4
Condit. Reinf. active responses	0.0	0.1	0.1	-0.2	0.3	-0.4	-0.1	-0.3	-0.1	-0.1	0.2	-0.3	0.0	0.2
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.1	0.1	-0.3	-0.1	-0.4	-0.5	-0.2	0.2	0.1	-0.5	-0.4
Incentive salience index mean	0.2	0.2	0.5	0.3	-0.2	0.5	0.2	0.4	0.7	0.6	-0.5	-0.2	0.7	-0.1
Condit. Reinf. lever presses	0.1	0.1	0.4	-0.0	0.0	0.4	-0.3	-0.1	0.3	0.4	-0.5	-0.6	0.3	-0.1
Condit. Reinf. active minus inactive responses	0.7	0.9	2.3	1.0	-0.6	0.6	1.3	0.5	1.3	1.0	-1.0	0.5	1.5	-0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	1.0	0.3	0.0	-0.1	0.7	-0.1	0.8	0.4	-0.3	-0.1	1.0	0.2
Condit. Reinf. active responses	0.6	0.9	1.9	1.0	-0.7	0.7	1.2	0.6	1.2	1.1	-1.0	0.4	1.4	-0.1
Condit. Reinf. inactive responses	0.9	1.1	1.7	1.1	-1.2	1.3	0.9	1.0	0.9	1.2	-1.1	0.8	0.8	-0.8
Condit. Reinf. lever presses	1.7	2.3	3.4	1.6	-1.4	1.4	1.8	1.1	1.8	1.7	-1.6	1.0	1.8	-1.0
Condit. Reinf. lever reinforcers received	0.3	0.5	1.4	0.7	-0.4	0.4	0.9	0.2	1.0	0.9	-0.8	0.0	1.2	0.2
Conditioned reinforcement - actives	0.2	0.2	1.3	0.2	-0.3	-0.3	0.5	0.4	0.1	-0.2	0.2	1.1	0.0	-0.8
Conditioned reinforcement - inactives	0.7	0.8	1.3	-0.9	0.7	-1.1	-0.8	-0.7	-1.0	-1.1	1.2	0.0	-1.1	0.3
Conditioned locomotion	0.1	0.2	0.3	-0.4	0.3	-0.5	-0.4	-0.4	-0.5	-0.6	0.4	-0.1	-0.5	0.2
Patch foraging indifference point 0 sec	0.4	0.7	1.8	0.9	-0.6	0.2	1.3	0.9	1.0	0.5	-0.4	0.9	1.2	-0.5
Patch foraging indifference point AUC	0.7	0.8	1.6	0.9	-1.0	0.7	0.9	1.2	0.7	0.5	-0.4	1.3	0.6	-1.0
Delay disc. indifference point, 0s delay	0.3	0.3	1.1	0.3	-0.7	0.6	0.1	0.7	-0.0	0.1	-0.3	1.1	-0.4	-0.5
Delay disc. indifference point, 16s delay	6.0	6.1	8.1	-2.6	2.6	-2.8	-2.3	-2.4	-2.4	-2.6	2.6	-2.0	-2.2	2.6
Delay disc. indifference point, 2s delay	3.8	4.2	5.5	2.1	-2.3	2.2	1.9	2.3	1.8	1.8	-2.0	2.3	1.5	-2.1
Delay disc. indifference point, 24s delay	5.1	5.0	5.5	-2.3	2.3	-2.3	-2.3	-2.2	-2.3	-2.2	2.3	-1.9	-2.2	2.1
Delay disc. indifference point, 4s delay	0.3	0.3	0.7	-0.3	0.0	-0.5	-0.2	0.2	-0.6	-0.9	0.6	0.8	-0.8	-0.0
Delay disc. indifference point, 8s delay	0.2	0.2	0.6	-0.4	0.2	-0.3	-0.5	0.0	-0.6	-0.6	0.5	0.2	-0.8	0.2
Indifference point function ln k	0.2	0.3	0.4	0.6	-0.6	0.5	0.6	0.5	0.6	0.5	-0.6	0.6	0.6	-0.4
Indifference point function log k	0.2	0.3	0.4	0.6	-0.6	0.5	0.6	0.5	0.6	0.5	-0.6	0.6	0.6	-0.4
Patch foraging total patch changes 0 sec	0.5	0.9	2.1	1.0	-0.7	0.3	1.4	0.9	1.2	0.6	-0.6	0.9	1.3	-0.6
Patch foraging total patch changes 12 sec	0.3	0.3	0.6	0.7	-0.5	0.5	0.7	0.5	0.7	0.7	-0.5	0.4	0.8	-0.4
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.2	0.2	-0.4	-0.0	0.0	-0.3	-0.5	0.5	0.2	-0.3	-0.4
Patch foraging total patch changes 24 sec	0.7	0.9	1.5	0.9	-0.8	0.5	1.2	1.1	1.0	0.6	-0.5	1.1	1.0	-1.2
Patch foraging total patch changes 6 sec	0.3	0.5	1.8	-0.4	0.6	-1.3	0.2	-0.1	-0.4	-1.1	1.2	0.4	-0.3	0.4
Patch foraging time to switch 0 sec	1.8	2.8	6.2	-1.8	1.8	-1.0	-2.0	-2.1	-1.5	-1.0	0.9	-2.5	-1.3	1.7
Patch foraging water rate 0 sec	0.3	0.5	0.6	0.7	-0.7	0.6	0.8	0.7	0.7	0.6	-0.7	0.7	0.7	-0.7
Patch foraging water rate 12 sec	1.2	1.8	3.1	1.4	-1.3	0.7	1.7	1.6	1.4	0.9	-0.9	1.7	1.3	-1.2
Patch foraging water rate 18 sec	0.4	0.5	1.0	0.7	-0.5	0.3	1.0	0.7	0.8	0.6	-0.6	0.6	0.9	-0.5
Patch foraging water rate 24 sec	0.4	0.6	1.8	0.7	-0.9	0.5	0.8	1.1	0.5	0.2	-0.4	1.3	0.3	-0.8
Patch foraging water rate 6 sec	0.1	0.2	0.6	-0.0	-0.1	-0.4	0.2	0.4	-0.3	-0.5	0.4	0.8	-0.4	-0.2
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.2	0.0	-0.1	-0.0	0.1	0.1	-0.1	-0.1	0.1	0.1	-0.1	-0.4
Distance traveled before self-admin	0.2	0.2	0.5	-0.2	-0.1	-0.2	-0.2	0.1	-0.5	-0.6	0.6	0.6	-0.7	-0.6
Distance traveled after self-admin	1.4	1.6	2.9	1.3	-1.6	1.4	1.0	1.5	0.9	0.9	-0.9	1.7	0.6	-1.6
Extensor digitorum longus weight	4.2	16.4	21.5	4.1	-4.6	4.6	3.5	4.5	3.7	3.8	-3.9	4.0	3.1	-4.4
Bone: elastic displacement	0.7	0.8	1.5	-0.9	0.9	-1.2	-0.6	-0.7	-1.0	-1.2	1.2	-0.3	-0.9	0.7
Bone: elastic work	0.2	0.2	0.7	0.5	-0.6	0.3	0.5	0.7	0.3	0.1	-0.1	0.8	0.2	-0.5
Bone: endosteal estimation	2.1	4.5	6.1	2.2	-2.1	2.5	1.9	2.1	2.4	2.5	-2.3	1.4	2.2	-1.4
Bone: endosteal perimeter	1.0	2.0	3.7	1.4	-1.5	1.9	1.0	1.2	1.3	1.7	-1.8	0.9	1.2	-1.1
Epididymis fat weight	1.0	2.2	3.6	1.6	-1.4	1.3	1.8	1.4	1.8	1.5	-1.5	1.1	1.9	-0.7
Delta time in closed arm before/after self-admin	0.2	0.2	0.8	-0.3	0.3	0.2	-0.6	-0.5	-0.2	0.1	-0.2	-0.9	-0.2	0.7
Delta time in open arm before/after self-admin	2.8	2.7	3.6	1.7	-1.7	1.4	1.8	1.9	1.7	1.4	-1.3	1.9	1.6	-1.5
Diff in mean of infusions in LGA sessions	0.4	0.5	1.4	-0.7	0.9	-1.2	-0.3	-0.7	-0.5	-0.8	0.8	-0.5	-0.3	0.6
Delay discount exponential model param	0.5	0.5	0.8	0.7	-0.6	0.8	0.7	0.5	0.9	0.9	-0.8	0.3	0.9	-0.7
Extinction: sum of active levers before priming	0.3	0.3	0.5	-0.7	0.6	-0.5	-0.7	-0.5	-0.5	-0.5	0.5	-0.6	-0.5	0.7
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.2	0.4	-0.5	0.1	-0.2	0.1	-0.3	0.1	-0.3	0.2	0.4
Bone: final force	5.9	9.5	11.9	3.3	-3.4	3.2	3.2	3.4	2.9	2.9	-2.9	3.2	2.5	-2.8
Bone: final moment	5.0	8.1	9.9	3.1	-3.1	2.9	3.0	3.1	2.7	2.7	-2.6	3.0	2.4	-2.6
Food consumed during 24 hour testing period	1.5	1.8	2.6	1.5	-1.6	1.5	1.3	1.5	1.2	1.2	-1.2	1.6	0.9	-1.1
Glucose	0.1	0.1	0.4	-0.1	0.1	-0.6	0.1	-0.2	-0.4	-0.5	0.7	0.4	-0.4	0.1
Heart weight	0.1	0.2	0.4	-0.3	0.2	-0.6	-0.1	-0.2	-0.6	-0.6	0.6	0.4	-0.6	0.5
Delay discount hyperbolic model param	0.2	0.2	0.5	0.5	-0.3	0.5	0.4	0.2	0.6	0.7	-0.5	-0.1	0.7	-0.4
Intermittent access intake day 1-15 change	1.3	1.3	2.5	-1.2	0.9	-0.9	-1.5	-1.0	-1.5	-1.2	1.2	-0.6	-1.6	0.7
Intermittent access intake escalation	1.0	1.0	2.0	-1.1	0.8	-0.8	-1.3	-0.9	-1.3	-1.1	1.1	-0.5	-1.4	0.5
Intermittent access intake escalation 2	1.3	1.3	2.4	-1.2	0.9	-0.8	-1.5	-0.9	-1.4	-1.1	1.2	-0.6	-1.5	0.8
Intermitt. access day 1 inactive lever presses	0.2	0.2	0.4	-0.4	0.3	-0.5	-0.4	-0.2	-0.5	-0.5	0.5	0.2	-0.6	0.4
Intermitt. access day 15 inactive lever presses	0.4	0.5	1.1	0.6	-0.9	0.8	0.5	0.7	0.5	0.5	-0.6	0.8	0.3	-1.1
Intermitt. access escalation Index	0.8	0.7	0.9	0.9	-0.9	0.9	0.9	0.8	0.8	0.9	-0.9	0.7	0.8	-0.8
Intermittent access day 1 total infusions	1.4	1.6	2.6	1.3	-1.1	0.9	1.6	1.1	1.4	1.1	-1.1	1.1	1.5	-1.5
Intermittent access day 15 total infusions	0.1	0.1	0.6	0.2	-0.2	-0.1	0.3	0.1	0.1	-0.0	0.0	0.4	0.1	-0.8
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.4	0.3	-0.2	-0.0	0.4	0.2	0.2	0.0	-0.0	0.4	0.2	-0.6
Intermittent access total infusions	0.8	0.9	1.8	1.0	-0.9	0.5	1.2	0.9	1.0	0.7	-0.7	1.0	1.0	-1.4
Intermittent access day 1 locomotion	1.2	1.3	2.4	1.3	-1.0	0.7	1.5	1.0	1.4	1.0	-1.0	1.0	1.4	-1.0
Intermittent access day 15 total locomotion	1.0	1.1	2.7	-1.0	1.2	-1.7	-0.6	-1.0	-0.9	-1.2	1.3	-0.5	-0.7	0.6
Intermittent access total locomotion	0.5	0.6	1.4	0.8	-0.4	0.1	1.2	0.6	1.0	0.6	-0.5	0.6	1.2	-0.8
Intermittent access standard deviation	0.1	0.1	0.4	0.1	-0.3	0.2	-0.0	0.3	-0.1	-0.0	0.1	0.6	-0.2	-0.5
Left kidney weight	3.7	10.4	13.0	3.4	-3.5	3.2	3.3	3.6	3.3	2.7	-2.9	3.3	2.9	-3.4
Right kidney weight	4.2	11.9	14.8	3.6	-3.7	3.4	3.5	3.9	3.5	3.0	-3.0	3.6	3.1	-3.4
Cocaine induced anxiety	0.1	0.1	0.2	-0.3	0.3	-0.2	-0.3	-0.4	-0.2	-0.1	0.1	-0.5	-0.1	0.2
Post-drug Anxiety	0.3	0.3	0.8	-0.5	0.6	-0.9	-0.3	-0.4	-0.5	-0.7	0.7	-0.1	-0.4	0.3
Baseline Anxiety	0.3	0.3	1.7	0.5	-0.6	0.1	0.6	0.7	0.2	-0.0	0.0	1.3	0.0	-0.7
Tail length	2.5	7.6	9.1	2.9	-3.0	2.6	3.0	3.0	2.7	2.3	-2.4	2.9	2.5	-2.8
Length with tail	0.3	1.2	2.5	1.2	-1.3	1.0	1.2	1.3	0.9	0.7	-0.8	1.6	0.7	-1.1
Length without tail	1.1	2.5	3.8	-1.6	1.4	-1.5	-1.7	-1.4	-1.9	-1.8	1.7	-0.9	-2.0	1.3
Times rat made contact with spout	1.0	1.1	2.2	1.0	-1.4	1.5	0.6	1.2	0.6	0.9	-0.9	1.3	0.3	-1.3
Lifetime Intake	1.7	1.9	3.4	1.5	-1.3	1.0	1.7	1.3	1.4	1.1	-1.1	1.4	1.4	-1.8
Liver weight, left	0.3	0.5	0.9	0.8	-0.6	0.7	0.8	0.2	0.8	0.9	-0.9	0.2	0.9	-0.3
Liver weight, right	0.9	1.6	3.2	1.1	-0.9	1.5	0.9	0.5	1.6	1.7	-1.8	-0.1	1.7	-0.4
Locomotor activity	0.1	0.2	0.5	0.3	-0.1	0.3	0.4	0.2	0.6	0.6	-0.5	-0.2	0.7	0.6
Locomotor testing distance	0.3	0.6	1.0	0.8	-0.6	0.6	1.0	0.6	0.9	0.8	-0.8	0.5	1.0	0.0
Locomotor testing rearing	0.1	0.2	0.7	0.3	0.0	0.1	0.5	-0.2	0.6	0.6	-0.5	-0.4	0.8	0.6
Locomotion in novel chamber	1.1	1.4	2.5	1.3	-0.9	0.9	1.5	0.9	1.4	1.2	-1.2	0.7	1.6	-0.9
Locomotion in novel chamber post-restriction	0.1	0.1	0.4	-0.1	0.4	-0.6	0.3	-0.5	0.2	-0.3	0.3	-0.3	0.4	0.4
Fecal boli incidents, locomotor time 1	0.4	0.4	2.0	-0.4	0.7	-0.2	-0.5	-1.0	-0.1	0.1	-0.0	-1.4	0.2	0.7
Change in fecal boli incidents, locomotor task	0.4	0.4	1.6	0.4	-0.4	-0.4	0.8	0.7	0.1	-0.6	0.3	1.3	-0.0	-0.6
Time >=10cm from walls, locomotor time 1	0.5	0.5	2.0	0.7	-0.9	0.7	0.6	0.7	0.3	0.3	-0.4	1.0	0.1	-1.4
Bouts of movement, locomotor time 1	3.1	3.4	5.0	-1.9	2.1	-1.8	-1.9	-2.2	-1.7	-1.6	1.5	-2.2	-1.5	1.9
Total resting periods, locomotor time 1	3.8	4.2	6.0	-2.1	2.3	-1.9	-2.1	-2.4	-1.9	-1.7	1.6	-2.4	-1.7	2.2
Rest time, locomotor task time 1	1.8	2.0	3.4	-1.5	1.2	-1.1	-1.7	-1.3	-1.7	-1.4	1.2	-1.1	-1.8	0.9
Distance moved, locomotor task time 1	2.5	2.8	3.8	1.7	-1.6	1.3	1.9	1.8	2.0	1.6	-1.5	1.6	1.9	-1.3
Vertical activity count, locomotor time 1	3.2	3.3	6.0	1.8	-2.0	1.5	1.9	2.3	1.7	1.4	-1.2	2.4	1.4	-2.0
Time >=10cm from walls, locomotor time 2	2.2	2.3	4.1	1.5	-1.8	1.6	1.4	1.8	1.2	1.3	-1.1	1.8	1.0	-2.0
Bouts of movement, locomotor time 2	0.9	0.9	2.7	0.7	-0.5	1.2	0.4	-0.1	1.1	1.5	-1.6	-0.7	1.2	0.3
Total resting periods, locomotor time 2	1.1	1.2	3.1	0.9	-0.7	1.4	0.6	0.2	1.2	1.6	-1.8	-0.4	1.3	0.1
Rest time, locomotor task time 2	0.0	0.1	0.2	-0.1	0.1	-0.3	0.0	-0.1	-0.3	-0.4	0.3	0.2	-0.3	-0.0
Distance moved, locomotor task time 2	0.4	0.5	1.1	0.5	-0.8	0.8	0.3	1.1	0.4	0.6	-0.4	1.0	0.1	-0.8
Vertical activity count, locomotor time 2	0.5	0.5	2.3	0.5	-0.9	0.4	0.4	1.2	0.2	0.2	0.1	1.5	-0.1	-0.9
Light reinforcement 1	0.1	0.2	0.5	-0.2	0.5	-0.5	0.1	-0.7	-0.1	-0.0	0.1	-0.6	0.3	0.7
Light reinforcement 2	0.1	0.1	0.5	0.3	0.0	-0.0	0.5	-0.1	0.5	0.3	-0.3	-0.1	0.7	0.5
Bone: marrow area	1.8	3.9	5.4	2.0	-2.0	2.3	1.8	1.9	2.2	2.3	-2.2	1.3	2.1	-1.2
Bone: maximum diameter	2.3	4.2	5.2	2.2	-2.2	2.3	2.1	2.1	2.0	2.0	-2.2	1.9	1.8	-1.4
Bone: maximum force	4.5	7.7	9.9	3.0	-3.1	2.9	2.8	3.1	2.5	2.5	-2.5	3.0	2.2	-2.5
Bone: maximum moment	3.7	6.3	8.0	2.7	-2.8	2.6	2.6	2.8	2.4	2.3	-2.3	2.8	2.1	-2.2
Mean time between licks in bursts	0.1	0.1	0.5	-0.1	0.2	0.2	-0.3	-0.6	-0.1	0.3	-0.3	-0.7	-0.0	0.5
Mean num. licks in bursts	8.0	9.6	11.1	3.3	-3.3	3.1	3.3	3.2	3.1	3.0	-3.0	3.1	2.9	-2.6
Cd content in liver	4.3	4.8	7.2	-2.3	2.5	-2.7	-1.8	-2.1	-1.6	-2.3	2.3	-2.1	-1.3	2.7
Co content in liver	0.7	0.9	1.9	-0.8	0.8	-1.3	-0.4	-0.5	-0.9	-1.4	1.4	-0.0	-0.9	0.8
Cu content in liver	0.2	0.3	0.8	0.6	-0.5	0.1	0.8	0.6	0.4	0.1	-0.1	0.9	0.4	-0.7
Fe content in liver	1.4	1.6	2.7	-1.3	1.1	-1.4	-1.2	-1.0	-1.6	-1.6	1.6	-0.4	-1.6	0.5
K content in liver	0.1	0.1	0.4	0.4	-0.2	0.3	0.4	0.3	0.6	0.4	-0.4	0.0	0.6	0.2
Mg content in liver	0.3	0.3	0.8	0.1	0.2	0.2	0.2	-0.4	0.6	0.6	-0.6	-0.9	0.9	0.9
Mn content in liver	0.2	0.3	0.6	0.4	-0.5	0.8	0.2	0.5	0.6	0.7	-0.7	0.2	0.5	-0.2
Na content in liver	4.9	5.2	8.2	2.3	-2.5	2.9	1.8	2.1	2.1	2.7	-2.7	1.6	1.8	-2.2
Rb content in liver	0.6	0.8	2.0	-0.6	1.0	-1.4	-0.1	-1.1	-0.7	-1.1	1.1	-0.4	-0.4	0.9
Se content in liver	0.0	0.0	0.1	0.2	-0.3	0.4	-0.0	0.2	-0.1	0.2	-0.2	0.2	-0.2	-0.1
Sr content in liver	0.9	0.8	1.3	0.9	-0.9	1.0	0.8	1.1	1.1	0.9	-0.9	0.7	1.0	-0.4
Zn content in liver	3.7	4.1	5.3	2.1	-2.0	2.2	2.0	1.8	2.1	2.3	-2.3	1.4	2.1	-1.7
Bone: minimum diameter	2.0	3.8	5.2	2.1	-2.1	2.3	1.8	1.9	1.9	2.0	-2.1	1.6	1.7	-1.8
Time in familiar zone, hab. session 1	0.8	0.8	1.6	-0.8	0.8	-1.2	-0.6	-0.5	-1.0	-1.2	1.3	-0.0	-1.0	0.1
Time in novel zone, hab. session 1	0.9	0.9	1.8	0.9	-0.8	1.2	0.7	0.4	1.0	1.2	-1.3	0.0	1.1	-0.6
Total zone transitions, hab. session 1	2.4	3.3	5.8	2.0	-2.1	1.5	2.1	2.0	1.5	1.4	-1.3	2.4	1.3	-2.2
Total locomotion distance, hab. session 1	5.9	8.3	11.1	3.1	-3.1	2.5	3.3	3.2	2.8	2.4	-2.3	3.3	2.5	-2.9
Locomotion velocity, hab. session 1	5.0	7.0	9.7	2.9	-2.8	2.3	3.1	2.9	2.7	2.3	-2.3	2.9	2.5	-2.4
Time in familiar zone, hab. session 2	0.3	0.3	0.6	0.6	-0.6	0.5	0.6	0.5	0.3	0.4	-0.3	0.8	0.2	-0.6
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.0	-0.1	0.1	0.0	-0.1	-0.3	0.2	0.3
Total zone transitions, hab. session 2	2.4	3.1	4.2	1.9	-1.8	1.4	2.0	1.9	1.7	1.5	-1.4	2.0	1.6	-1.8
Total locomotion distance, hab. session 2	3.2	4.2	6.6	2.2	-2.2	1.7	2.3	2.4	1.9	1.6	-1.5	2.6	1.6	-2.2
Locomotion velocity, hab. session 2	3.8	5.2	7.2	2.4	-2.5	2.0	2.5	2.6	2.1	1.9	-1.8	2.7	1.9	-2.4
Novel to familiar place preference ratio	0.9	1.0	1.3	-1.1	1.0	-1.1	-1.0	-0.8	-1.1	-1.1	1.1	-0.6	-1.1	0.7
Novelty place preference	1.3	1.3	2.1	-1.2	1.0	-1.2	-1.2	-0.9	-1.4	-1.3	1.3	-0.5	-1.4	0.6
Time in novel zone, NPP test	1.0	1.0	1.5	-1.1	1.0	-1.1	-1.0	-0.9	-1.2	-1.1	1.2	-0.5	-1.2	0.5
Total zone transitions, NPP test	1.6	2.3	3.2	1.6	-1.7	1.4	1.7	1.6	1.4	1.3	-1.3	1.8	1.2	-1.5
Total locomotion distance, NPP test	1.6	2.2	4.2	1.6	-1.7	1.3	1.6	1.8	1.2	1.0	-1.1	2.1	1.0	-1.4
Locomotion velocity, NPP test	1.2	1.7	3.6	1.4	-1.6	1.1	1.4	1.7	1.0	0.8	-0.9	1.9	0.8	-1.2
Intraocular pressure	0.3	0.4	0.6	0.7	-0.6	0.7	0.7	0.5	0.7	0.8	-0.8	0.3	0.6	-0.3
Delta distance traveled before/after self-admin	1.7	1.8	2.4	1.4	-1.4	1.5	1.3	1.3	1.4	1.4	-1.5	0.9	1.4	-1.1
Delta ambulatory time before/after self-admin	1.3	1.4	1.8	1.2	-1.3	1.3	1.1	1.3	1.2	1.2	-1.2	1.0	1.1	-0.9
Parametrial fat weight	2.8	5.5	7.2	2.5	-2.4	2.0	2.7	2.3	2.5	2.0	-2.0	2.4	2.4	-2.4
Pavlov. Cond. lever latency	1.7	2.1	4.7	-1.3	1.0	-1.9	-0.9	-0.6	-1.7	-2.2	2.2	0.3	-1.8	0.3
Pavlov. Cond. magazine entry latency	4.3	5.5	9.5	2.3	-2.0	2.8	1.9	1.6	2.7	3.1	-3.1	0.5	2.8	-1.7
Pavlov. Cond. change in total contacts	1.6	1.7	4.3	1.1	-1.0	2.0	0.5	0.6	1.4	2.0	-2.1	-0.4	1.4	-0.4
Pavlov. Cond. index score	2.7	3.4	7.2	1.6	-1.3	2.3	1.2	0.9	2.2	2.6	-2.7	-0.3	2.3	-0.7
Pavlov. Cond. latency score	2.4	3.1	6.5	1.6	-1.3	2.2	1.2	0.9	2.1	2.5	-2.5	-0.2	2.2	-0.7
Pavlov. Cond. lever contacts	2.7	3.1	6.7	1.6	-1.4	2.3	1.1	0.9	2.0	2.6	-2.6	-0.2	2.1	-0.8
Pavlov. Cond. magazine entry number	2.3	2.8	6.1	-1.5	1.3	-2.3	-1.0	-0.9	-1.9	-2.4	2.5	0.2	-2.0	0.7
Pavlov. Cond. intertrial magazine entries	1.4	1.7	3.2	-1.2	1.2	-1.8	-0.8	-1.0	-1.2	-1.7	1.7	-0.4	-1.1	1.2
Pavlov. Cond. lever-magazine prob. diff.	3.4	4.2	8.6	1.9	-1.6	2.6	1.5	1.1	2.4	2.9	-2.9	-0.1	2.6	-0.8
Pavlov. Cond. response bias	2.4	3.0	6.6	1.5	-1.3	2.4	1.0	0.8	1.9	2.6	-2.6	-0.3	2.0	-0.8
Pavlov. Cond. lever latency	1.1	1.5	2.0	-1.3	1.2	-1.1	-1.4	-1.0	-1.3	-1.2	1.2	-1.0	-1.3	1.0
Pavlov. Cond. magazine entry latency	1.2	1.4	2.6	-1.3	1.2	-0.8	-1.5	-1.5	-1.1	-0.7	0.7	-1.6	-1.1	1.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.1	0.2	-0.5	0.4	-0.2	0.2	-0.2	0.2	0.0	0.4	0.2
Pavlov. Cond. index score	0.0	0.0	0.2	-0.1	0.2	-0.0	-0.0	-0.4	0.0	0.1	-0.1	-0.4	0.2	0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	0.0	0.0	0.1	0.0	-0.2	0.1	0.2	-0.2	-0.3	0.2	0.1
Pavlov. Cond. lever contacts	1.4	1.9	2.6	1.5	-1.3	1.3	1.6	1.1	1.6	1.5	-1.5	0.9	1.6	-1.1
Pavlov. Cond. magazine entry number	2.0	2.5	3.3	1.7	-1.7	1.5	1.6	1.8	1.5	1.4	-1.3	1.8	1.3	-1.6
Pavlov. Cond. intertrial magazine entries	3.5	4.6	5.9	2.3	-2.1	2.2	2.3	2.1	2.4	2.2	-2.2	1.6	2.4	-1.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	-0.2	0.4	-0.1	-0.3	-0.5	-0.1	0.0	-0.0	-0.7	0.0	0.4
Pavlov. Cond. response bias	0.1	0.2	0.5	0.4	-0.2	0.4	0.5	0.1	0.6	0.6	-0.6	-0.1	0.7	-0.2
Time in closed arm before self-admin	0.7	0.8	1.6	0.9	-1.0	0.7	1.0	0.8	0.6	0.5	-0.5	1.2	0.6	-1.3
Time in closed arm after self-admin	0.9	1.0	1.7	-1.0	1.0	-1.3	-0.7	-0.9	-1.0	-1.2	1.1	-0.6	-0.9	0.9
Time in open arm before self-admin	2.2	2.3	3.4	-1.6	1.7	-1.4	-1.7	-1.6	-1.4	-1.1	1.2	-1.8	-1.2	1.8
Time in open arm after self-admin	1.5	1.7	2.6	1.3	-1.5	1.6	1.0	1.5	1.2	1.4	-1.2	1.2	1.0	-1.1
Bone: periosteal estimation	3.5	7.2	8.9	2.8	-2.9	3.0	2.6	2.8	2.7	2.7	-2.7	2.4	2.4	-2.2
Bone: periosteal perimeter	1.8	3.1	4.2	1.9	-1.8	2.0	1.7	1.5	1.8	1.9	-2.0	1.3	1.7	-1.5
Bone: post-yield work	3.7	5.0	8.2	2.3	-2.0	2.0	2.5	2.1	2.8	2.4	-2.3	1.5	2.9	-1.4
Progressive ratio test 1 active lever presses	0.5	0.5	0.9	0.8	-0.6	0.5	0.9	0.5	0.8	0.6	-0.6	0.4	0.9	-0.8
Progressive ratio test 1 breakpoint	0.4	0.4	0.8	0.7	-0.5	0.4	0.9	0.5	0.8	0.6	-0.6	0.4	0.8	-0.7
Progressive ratio test 1 inactive lever presses	0.5	0.5	0.8	0.8	-0.7	0.6	0.8	0.7	0.8	0.7	-0.7	0.6	0.8	-0.9
Progressive ratio test 2 active lever presses	0.2	0.3	0.6	0.6	-0.4	0.2	0.8	0.4	0.6	0.3	-0.4	0.4	0.7	-0.7
Progressive ratio test 2 breakpoint	0.2	0.2	0.6	0.5	-0.3	0.2	0.8	0.3	0.6	0.3	-0.4	0.3	0.7	-0.6
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.2	-0.0	-0.1	0.5	0.1	0.4	0.1	-0.2	0.1	0.5	-0.3
Incentive Sensitization - Responses	0.0	0.0	0.1	0.1	0.0	0.1	0.2	-0.1	0.2	0.2	-0.2	-0.3	0.3	-0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.2	-0.0	0.1	0.3	-0.0	0.3	0.2	-0.2	-0.2	0.4	-0.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.4	0.1	0.2	0.1	0.2	-0.2	0.5	0.4	-0.4	-0.6	0.7	0.2
Progressive ratio	0.1	0.1	0.4	-0.1	0.3	-0.6	0.2	0.0	0.1	-0.5	0.2	0.2	0.2	0.2
Food seeking constrained by brief footshock	1.7	2.1	2.6	-1.5	1.5	-1.6	-1.4	-1.1	-1.5	-1.6	1.5	-0.9	-1.5	1.6
Seeking ratio, punishment vs. effort	0.0	0.1	0.3	0.1	-0.2	0.5	-0.2	0.0	0.0	0.4	-0.2	-0.2	-0.0	-0.0
Retroperitoneal fat weight	0.3	1.0	3.1	1.1	-0.6	0.3	1.6	0.5	1.5	0.9	-0.9	0.6	1.8	0.2
Reaction time number correct	0.6	0.8	1.7	-0.9	1.1	-0.9	-0.8	-1.2	-0.7	-0.6	0.6	-1.3	-0.5	0.9
Reaction time mean minus median	0.1	0.1	0.4	0.3	-0.4	0.3	0.3	0.4	0.4	0.1	-0.1	0.5	0.3	-0.7
Reaction time mean minus median AUC	0.0	0.1	0.2	-0.2	0.3	-0.4	0.0	-0.2	0.1	-0.3	0.3	-0.1	0.2	-0.2
Reaction time num false alarms	1.0	1.4	2.4	-1.3	1.0	-1.0	-1.5	-0.7	-1.4	-1.3	1.4	-0.6	-1.6	0.9
Reaction time num false alarms AUC	0.6	0.8	1.5	-1.0	0.8	-0.7	-1.2	-0.6	-1.0	-0.9	1.0	-0.7	-1.1	0.7
Reaction time trials correct on left	0.6	0.8	1.7	-0.9	1.1	-0.9	-0.8	-1.2	-0.7	-0.6	0.6	-1.3	-0.5	0.9
Reaction time trials on left	0.6	0.8	1.7	-0.9	1.1	-0.9	-0.8	-1.2	-0.6	-0.6	0.6	-1.3	-0.4	0.9
Reaction time mean	0.5	0.7	1.3	0.8	-0.7	0.7	0.9	0.8	1.1	0.6	-0.6	0.6	1.1	-0.9
Reaction time mean AUC	0.3	0.4	0.9	0.5	-0.4	0.5	0.6	0.4	0.9	0.5	-0.5	0.2	1.0	-0.5
Median of all reaction times	0.5	0.7	1.5	0.8	-0.7	0.7	0.9	0.8	1.2	0.8	-0.8	0.5	1.2	-0.8
Reaction time omissions	0.2	0.3	1.4	-0.3	0.5	-0.1	-0.4	-0.7	0.3	0.2	-0.2	-1.2	0.5	0.5
Reaction time false alarm rate	0.2	0.3	0.9	-0.5	0.2	-0.2	-0.8	0.0	-0.7	-0.5	0.6	0.0	-0.9	0.1
Reaction time premature initiation rate	1.2	1.6	2.5	1.3	-1.5	1.5	1.0	1.5	1.0	1.2	-1.0	1.4	0.7	-1.6
Reaction time premature initiations	0.3	0.4	0.9	0.5	-0.7	0.8	0.3	0.7	0.4	0.7	-0.5	0.4	0.3	-0.9
Std. dev. reaction times	0.3	0.4	0.7	0.6	-0.6	0.4	0.7	0.6	0.8	0.4	-0.4	0.6	0.8	-0.8
Reaction time trials completed	0.6	0.8	1.7	-0.9	1.1	-0.9	-0.8	-1.2	-0.6	-0.6	0.6	-1.3	-0.4	0.9
Reaction time trials AUC	0.4	0.5	1.2	-0.7	0.9	-0.7	-0.7	-1.0	-0.5	-0.5	0.5	-1.1	-0.3	0.7
Run reversals in cocaine runway, females	5.6	5.4	7.8	2.4	-2.7	2.5	2.2	2.7	2.0	2.0	-2.1	2.8	1.6	-2.3
Run reversals in cocaine runway, males	0.6	0.6	1.1	-0.8	0.7	-0.7	-0.9	-0.6	-1.0	-0.9	0.8	-0.4	-1.0	0.3
Latency to leave start box in cocaine runway	0.2	0.2	0.6	-0.3	0.5	-0.8	0.1	-0.3	-0.2	-0.5	0.6	-0.1	-0.0	0.3
Latency to leave start box in cocaine runway, F	0.2	0.2	0.6	-0.3	0.6	-0.4	-0.2	-0.7	-0.2	-0.1	0.2	-0.8	0.0	0.5
Latency to leave start box in cocaine runway, M	0.4	0.4	1.1	-0.4	0.4	-1.0	0.0	-0.1	-0.5	-1.0	1.0	0.5	-0.5	-0.0
Std. dev. time between licks in bursts	0.3	0.4	0.9	0.5	-0.3	0.7	0.4	0.1	0.7	1.0	-1.0	-0.3	0.9	0.3
Total sessions with >9 infusions	4.8	5.3	7.3	2.4	-2.5	2.2	2.4	2.3	2.1	1.9	-2.0	2.6	1.9	-2.7
Short access day 1 total inactive lever presses	0.0	0.0	0.2	0.1	-0.1	-0.2	0.3	0.1	0.1	-0.0	0.1	0.4	0.1	-0.3
Short access day 10 total inactive lever presses	1.1	1.2	1.7	-1.2	1.0	-1.2	-1.2	-0.9	-1.3	-1.2	1.3	-0.4	-1.3	0.8
Short access day 1 total infusions	1.4	1.5	2.4	1.3	-1.2	0.8	1.5	1.3	1.2	0.9	-0.9	1.5	1.2	-1.3
Short access day 10 total infusions	1.8	2.0	3.8	1.5	-1.5	1.3	1.5	1.3	1.3	1.2	-1.2	1.4	1.2	-1.9
Short access total infusions	2.9	3.3	4.9	1.9	-1.8	1.4	2.2	1.7	1.8	1.5	-1.5	1.9	1.8	-2.2
Short access day 1 locomotion	0.2	0.2	0.7	0.4	-0.4	0.1	0.6	0.5	0.4	0.1	-0.1	0.8	0.3	-0.6
Short access day 10 total locomotion	2.5	2.8	3.9	1.8	-1.6	1.6	1.9	1.6	2.0	1.8	-1.7	1.1	2.0	-1.3
Short access total locomotion	2.3	2.4	4.5	1.7	-1.4	0.9	2.1	1.5	1.8	1.3	-1.3	1.6	1.9	-1.4
One hour access (0.3 mA shock)	2.5	2.9	3.9	1.8	-1.5	1.4	2.0	1.5	1.9	1.7	-1.7	1.2	2.0	-1.9
Compulsive drug intake	0.6	0.6	1.5	0.7	-0.3	0.6	0.8	0.5	1.1	0.9	-0.9	-0.2	1.2	0.2
One hour access (shock baseline)	0.1	0.1	0.3	-0.3	0.3	-0.5	-0.2	-0.3	-0.4	-0.5	0.5	0.1	-0.4	-0.3
Social response proportion	0.2	0.2	0.6	-0.2	0.5	-0.5	0.1	-0.4	0.2	-0.1	0.1	-0.5	0.5	0.8
Social responses	0.6	0.7	1.9	-0.7	1.0	-0.7	-0.6	-1.1	-0.5	-0.3	0.3	-1.3	-0.2	1.4
Social time	1.4	1.8	2.7	-1.4	1.5	-1.6	-1.2	-1.4	-1.3	-1.2	1.3	-1.2	-1.1	1.6
Soleus weight	2.0	5.8	10.5	2.5	-2.7	2.1	2.5	3.2	2.3	1.5	-1.6	3.2	1.8	-2.4
Bone: stiffness	3.1	4.9	7.6	2.4	-2.7	2.4	2.2	2.6	1.8	1.9	-1.9	2.7	1.4	-2.0
Tibialis anterior weight	6.5	22.1	28.1	5.0	-5.3	4.8	4.8	5.2	4.3	4.1	-4.2	5.2	3.7	-5.0
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	0.5	-0.5	0.7	0.3	0.6	0.5	0.6	-0.6	0.4	0.3	-0.3
Time to tail flick, vehicle, after self-admin	1.3	1.3	2.8	-1.2	1.3	-1.0	-1.2	-1.5	-1.0	-0.8	0.7	-1.7	-0.8	1.3
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.0	-0.2	0.4	-0.2	0.1	-0.2	0.1	-0.0	0.2	-0.4	-0.1
Time to tail flick, test, after self-admin	1.0	1.0	2.2	-1.1	0.9	-0.3	-1.5	-1.2	-1.1	-0.5	0.5	-1.5	-1.1	0.8
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.7	-0.3	0.5	-0.4	-0.2	-0.7	-0.1	-0.1	0.0	-0.8	0.1	0.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.5	-0.2	0.3	0.0	-0.3	-0.3	-0.0	0.0	-0.1	-0.7	0.0	0.1
Tibia length	0.1	0.2	0.5	-0.2	0.2	-0.5	-0.0	0.2	-0.4	-0.7	0.6	0.4	-0.5	-0.1
Ambulatory time before self-admin	0.4	0.4	1.0	-0.4	0.1	-0.6	-0.4	-0.0	-0.8	-1.0	1.0	0.6	-1.0	-0.4
Ambulatory time after self-admin	1.4	1.6	3.4	1.2	-1.6	1.3	1.0	1.6	0.8	0.8	-0.8	1.8	0.5	-1.5
Bone: tissue strength	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.2	0.1	-0.2	-0.1	0.1	0.2	-0.3	-0.1
Total heroin consumption	0.4	0.5	1.2	-0.6	0.9	-0.9	-0.3	-0.9	-0.2	-0.5	0.4	-1.1	0.0	0.8
Bone: trabecular number	0.6	0.9	1.5	1.0	-1.0	0.8	1.0	1.2	0.8	0.7	-0.6	1.2	0.6	-1.2
Bone: trabecular spacing	0.5	0.7	2.6	-0.6	0.9	-0.3	-0.7	-1.3	-0.3	-0.0	-0.2	-1.6	-0.0	1.1
Bone: trabecular thickness	2.1	2.5	5.5	1.6	-1.6	0.8	2.1	2.1	1.5	0.7	-0.7	2.3	1.4	-1.6
Bone: trabecular tissue density	0.0	0.1	0.1	-0.1	-0.0	-0.1	-0.1	0.1	-0.3	-0.3	0.2	0.3	-0.4	0.3
Water consumed over 24 hours	1.1	1.4	3.1	-1.2	0.8	-0.5	-1.7	-0.9	-1.5	-1.1	1.1	-0.8	-1.8	0.5
Number of responses in last shaping day	0.6	0.6	0.8	0.9	-0.8	0.8	0.9	0.8	0.8	0.8	-0.8	0.8	0.8	-0.6