Hub : Genes

Tmc7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr1_182317521_182320753 0.05 0.03 9.6e-08 0.04 0.05 0.05 0.04 1.1e-06 1.1e-07 9.6e-08 2.0e-07
2 pVTA intron excision ratio chr1_182318507_182320753 0.03 0.02 4.9e-03 0.03 0.02 0.01 0.02 2.2e-03 6.8e-03 2.7e-02 9.0e-03
3 PL mRNA stability Tmc7 0.02 0.02 6.6e-03 0.01 0.01 0 0.01 1.4e-02 2.2e-02 1.4e-01 3.7e-02
4 IC gene expression Tmc7 0.28 0.14 2.0e-10 0.16 0.2 0.19 0.18 2.4e-07 6.1e-09 2.6e-08 3.4e-08
5 PL gene expression Tmc7 0.29 0.11 0.0e+00 0.21 0.22 0.23 0.23 5.4e-23 3.2e-24 7.6e-25 1.1e-24
6 Brain gene expression Tmc7 0.16 0.07 1.9e-12 0.13 0.1 0.13 0.12 2.2e-12 5.8e-10 5.6e-12 1.0e-11
7 Brain intron excision ratio chr1_182317521_182320753 0.06 0.04 7.4e-04 0.04 0.02 0.02 0.03 6.2e-05 4.0e-03 2.8e-03 9.1e-04
8 Brain mRNA stability Tmc7 0.04 0.03 1.9e-03 0.01 0.01 0 0 8.7e-02 7.4e-02 1.1e-01 1.2e-01
9 BLA gene expression Tmc7 0.14 0.08 9.1e-06 0.1 0.08 0.06 0.09 3.7e-06 5.3e-05 3.2e-04 2.2e-05
10 NAcc gene expression Tmc7 0.16 0.07 0.0e+00 0.18 0.16 0.18 0.17 1.6e-26 4.2e-24 6.7e-26 5.2e-25
11 IL gene expression Tmc7 0.26 0.13 9.1e-04 0.06 0.09 0.1 0.09 1.8e-02 4.6e-03 2.3e-03 3.3e-03
12 pVTA intron excision ratio chr1_182317521_182320753 0.07 0.04 1.4e-05 0.05 0.06 0.06 0.05 4.4e-05 2.6e-05 2.0e-05 3.5e-05
13 NAcc alternative TSS XM_063271314.1 0.02 0.01 2.8e-03 0.02 0.01 0.01 0.02 5.4e-04 1.8e-03 2.8e-03 2.3e-04
14 OFC gene expression Tmc7 0.38 0.15 7.5e-06 0.2 0.15 0.14 0.17 1.5e-05 2.6e-04 3.7e-04 8.8e-05
15 NAcc alternative TSS XM_063271314.1 0.01 0.01 5.3e-03 0.02 0.01 0.01 0.01 1.1e-03 9.9e-03 2.0e-02 3.0e-03
16 NAcc alternative TSS NM_001191950.2 0.01 0.01 9.1e-03 0.02 0.01 0.01 0.02 1.9e-04 3.7e-03 9.0e-03 4.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density1.11.83.3-1.61.71.71.51.41.3-1.21.71.11.11.3-1.8-1.11.20.10.7
Area under the delay curve0.30.40.90.6-0.3-0.3-0.7-0.8-0.80.90.0-0.8-0.8-0.9-0.20.3-0.50.3-0.2
BMI with tail4.114.019.5-4.24.24.24.34.44.0-4.43.44.14.14.0-2.8-2.73.7-2.21.7
BMI without tail6.519.728.3-5.35.15.25.15.14.7-5.04.54.54.54.7-4.0-3.34.2-1.62.1
Body weight2.812.318.0-4.23.93.84.04.03.7-3.83.53.53.53.8-3.4-3.03.2-1.22.1
Weight adjusted by age0.50.71.8-0.90.30.30.91.11.4-1.3-0.41.11.11.30.1-0.5-0.1-0.40.2
Bone surface1.12.02.9-1.61.51.61.41.41.5-1.31.31.41.41.2-1.2-1.71.4-0.91.5
Bone volume1.73.04.5-2.12.12.11.91.81.9-1.62.01.61.61.6-1.7-1.71.8-0.71.3
Breakpoint value in progressive ratio session1.01.22.61.2-1.4-1.4-0.9-0.8-0.90.8-1.5-0.8-0.8-0.41.11.0-1.61.2-0.7
Number of licking bursts4.16.710.33.1-2.6-2.6-3.2-3.1-2.82.7-2.5-2.7-2.7-3.22.71.9-2.10.1-1.4
Context. condit. distance diff. score0.20.20.50.4-0.7-0.7-0.3-0.3-0.50.2-0.7-0.3-0.3-0.00.30.5-0.60.7-0.3
Locomotion velocity, session 10.10.10.40.2-0.1-0.1-0.3-0.4-0.40.60.3-0.4-0.4-0.6-0.5-0.30.40.10.4
Locomotion distance, session 10.91.22.5-1.30.80.91.41.31.2-0.81.11.11.11.4-1.6-0.80.70.20.6
Locomotion velocity, session 20.30.31.00.6-0.4-0.5-0.6-0.8-0.61.00.0-0.7-0.7-0.80.20.0-0.00.10.1
Locomotion distance, session 21.72.35.0-1.61.51.51.61.51.5-1.11.71.41.41.3-2.2-1.81.6-0.31.5
Locomotion velocity, session 30.40.41.1-0.70.40.50.70.60.5-0.40.60.60.60.6-1.0-1.00.60.11.0
Locomotion distance, session 30.30.31.9-0.20.30.30.10.20.4-0.5-0.10.50.5-0.00.0-1.20.3-1.01.4
Stereotopy head waving bouts, day 30.50.60.90.7-0.8-0.8-0.6-0.7-0.80.8-0.5-0.8-0.8-0.5-0.11.0-0.91.0-0.9
Stereotopy head waving duration, day 30.20.20.60.1-0.4-0.4-0.1-0.2-0.40.4-0.1-0.4-0.40.0-0.30.7-0.40.8-0.7
Locomotion velocity, session 71.92.06.5-1.11.01.01.01.11.2-1.40.51.41.40.90.4-2.41.3-2.12.5
Locomotion distance, session 70.50.63.30.2-0.0-0.0-0.4-0.20.2-0.1-0.40.10.1-0.41.8-1.00.1-1.81.2
Stereotopy head waving bouts, day 70.40.43.7-0.40.10.10.60.40.1-0.10.40.30.30.5-1.9-0.30.51.10.3
Stereotopy head waving duration, day 72.02.45.6-1.81.31.31.91.71.4-1.51.31.61.61.8-2.4-1.31.50.11.0
Locomotion velocity, session 80.10.21.70.1-0.1-0.00.1-0.1-0.20.30.3-0.1-0.1-0.0-1.3-0.20.10.90.3
Locomotion distance, session 80.20.30.8-0.50.40.40.60.60.5-0.50.40.60.60.7-0.9-0.70.60.20.7
Degree of sensitization distance0.30.31.80.2-0.1-0.1-0.2-0.3-0.40.50.2-0.6-0.6-0.20.71.2-0.40.4-1.3
Degree of sensitization stereotypy1.61.85.8-1.31.11.11.41.21.1-1.01.21.21.21.2-2.4-1.61.50.11.4
Conditioned locomotion0.70.93.80.9-1.0-1.1-1.0-0.7-0.50.5-1.4-0.3-0.3-0.82.0-0.3-0.7-1.10.8
Cocaine response after cond. corrected0.20.30.90.6-0.3-0.4-0.6-0.6-0.50.5-0.4-0.4-0.4-0.71.00.5-0.4-0.0-0.4
Cocaine response after cond. not corrected0.10.10.3-0.20.50.50.10.20.3-0.40.20.30.30.00.3-0.40.4-0.40.4
Cocaine response before conditioning2.42.85.0-1.71.82.01.51.61.6-1.81.41.61.61.3-1.2-2.21.8-1.42.1
Saline control response0.20.20.80.1-0.3-0.2-0.1-0.2-0.20.2-0.1-0.4-0.40.00.00.9-0.60.9-0.9
Bone: connectivity density0.81.31.9-1.31.21.21.31.31.3-1.40.91.21.21.3-1.0-1.01.0-0.30.8
Bone: cortical apparent density1.01.42.31.4-0.9-0.9-1.5-1.4-1.41.1-1.0-1.4-1.4-1.50.81.1-1.30.6-0.8
Bone: cortical area2.84.36.5-2.52.52.62.22.12.2-1.92.52.02.01.8-1.9-2.12.1-1.11.6
Bone: cortical porosity1.11.22.1-1.20.90.81.41.41.2-1.20.61.31.31.5-0.9-1.00.9-0.40.8
Bone: cortical porosity0.50.51.5-0.80.40.31.11.00.8-0.90.20.90.91.2-0.5-0.60.2-0.00.6
Bone: cortical thickness0.71.24.2-1.21.51.51.00.80.8-0.32.10.50.50.5-1.4-1.01.6-0.40.6
Bone: cortical thickness0.40.52.2-0.20.70.80.0-0.2-0.20.71.5-0.6-0.6-0.5-1.1-0.31.10.10.1
Bone: cortical tissue density1.01.42.31.4-0.9-0.9-1.5-1.4-1.41.1-1.0-1.4-1.4-1.50.81.1-1.30.6-0.8
Condit. Reinf. active minus inactive responses0.10.10.40.2-0.1-0.10.00.1-0.1-0.2-0.3-0.1-0.10.2-0.20.3-0.40.6-0.2
Condit. Reinf. active-inactive response ratio0.10.10.8-0.10.30.20.40.50.2-0.9-0.30.40.40.6-0.1-0.1-0.30.20.2
Condit. Reinf. active responses0.10.10.40.3-0.4-0.3-0.1-0.1-0.20.2-0.2-0.2-0.20.00.10.6-0.30.4-0.6
Condit. Reinf. inactive responses0.10.10.7-0.0-0.4-0.3-0.1-0.20.10.70.2-0.2-0.20.00.20.60.00.1-0.8
Incentive salience index mean0.10.20.7-0.10.30.30.30.40.4-0.8-0.20.50.50.40.0-0.40.1-0.60.5
Condit. Reinf. lever presses0.20.31.50.10.0-0.00.10.30.5-0.8-0.60.60.60.31.0-0.40.0-1.20.5
Condit. Reinf. active minus inactive responses1.11.53.8-1.40.90.71.61.61.3-1.30.91.11.11.9-1.50.50.11.0-1.0
Condit. Reinf. active-inactive response ratio0.60.72.5-0.60.30.00.80.80.6-0.60.30.40.41.2-0.51.2-0.61.2-1.6
Condit. Reinf. active responses0.91.23.0-1.30.80.71.41.41.2-1.40.71.21.21.7-1.60.10.20.6-0.5
Condit. Reinf. inactive responses1.01.32.4-1.01.01.10.91.01.0-1.30.71.21.20.8-1.2-1.51.1-1.11.5
Condit. Reinf. lever presses1.82.54.7-1.81.41.32.02.01.9-1.91.31.81.82.2-1.8-0.60.80.40.1
Condit. Reinf. lever reinforcers received0.60.82.4-1.00.50.31.21.21.0-1.10.40.90.91.5-1.00.4-0.20.8-0.7
Conditioned reinforcement - actives0.10.10.6-0.10.30.20.0-0.2-0.20.20.8-0.3-0.3-0.1-0.3-0.20.40.60.2
Conditioned reinforcement - inactives0.71.11.71.2-0.9-0.9-1.2-1.2-1.31.2-0.3-1.2-1.2-1.20.61.0-1.00.7-1.0
Conditioned locomotion0.10.10.30.3-0.2-0.2-0.4-0.4-0.30.4-0.1-0.3-0.3-0.40.30.0-0.50.10.0
Patch foraging indifference point 0 sec0.51.04.1-1.10.60.81.11.00.9-0.51.10.30.31.2-2.00.30.41.7-0.6
Patch foraging indifference point AUC0.40.51.6-0.91.01.10.60.60.8-0.41.30.20.20.4-1.20.00.80.2-0.4
Delay disc. indifference point, 0s delay0.60.61.5-0.41.21.10.10.30.6-0.51.00.60.6-0.4-1.0-1.00.8-1.10.7
Delay disc. indifference point, 16s delay4.34.85.92.4-2.3-2.3-2.1-2.3-2.42.4-1.7-2.4-2.4-1.91.32.3-2.42.0-1.9
Delay disc. indifference point, 2s delay3.53.96.1-2.02.52.41.81.91.9-1.92.22.12.11.3-1.7-2.12.5-1.61.5
Delay disc. indifference point, 24s delay3.64.05.92.4-2.2-2.2-2.2-2.3-2.42.2-1.9-2.3-2.3-2.00.81.6-2.01.3-1.1
Delay disc. indifference point, 4s delay0.20.20.70.10.40.3-0.4-0.5-0.30.70.8-0.5-0.5-0.8-0.60.20.00.3-0.3
Delay disc. indifference point, 8s delay0.10.10.30.10.10.1-0.4-0.4-0.30.40.3-0.4-0.4-0.6-0.1-0.4-0.1-0.50.5
Indifference point function ln k0.10.20.3-0.30.40.50.40.40.2-0.30.40.40.40.30.4-0.40.4-0.40.3
Indifference point function log k0.10.20.3-0.30.40.50.40.40.2-0.30.40.40.40.30.4-0.40.4-0.40.3
Patch foraging total patch changes 0 sec0.61.24.0-1.20.60.91.31.11.0-0.61.20.40.41.4-2.00.40.41.8-0.8
Patch foraging total patch changes 12 sec0.30.41.0-0.80.20.40.70.71.0-0.70.40.40.40.8-1.00.00.10.6-0.2
Patch foraging total patch changes 18 sec0.20.42.4-0.2-0.20.1-0.0-0.20.10.40.5-0.6-0.6-0.1-1.50.60.41.2-0.7
Patch foraging total patch changes 24 sec0.50.94.0-1.10.91.11.00.90.7-0.61.20.30.31.0-2.00.00.60.9-0.3
Patch foraging total patch changes 6 sec1.21.99.80.2-0.4-0.2-0.0-0.3-0.70.90.8-1.3-1.3-0.0-2.12.1-0.53.1-2.4
Patch foraging time to switch 0 sec1.22.57.31.9-2.3-2.2-1.8-1.6-1.11.0-2.7-0.9-0.9-1.51.90.1-1.6-0.60.7
Patch foraging water rate 0 sec0.20.51.0-1.00.80.80.80.81.0-0.50.80.70.70.9-0.1-0.20.6-0.1-0.1
Patch foraging water rate 12 sec0.71.43.4-1.41.51.51.51.20.9-0.71.80.70.71.3-1.8-0.31.20.7-0.2
Patch foraging water rate 18 sec0.30.51.2-1.00.70.81.00.90.6-0.50.80.70.71.1-0.3-0.10.50.6-0.2
Patch foraging water rate 24 sec0.30.51.6-0.81.21.10.60.50.3-0.21.30.40.40.3-0.4-0.50.8-0.30.3
Patch foraging water rate 6 sec0.30.52.10.20.20.4-0.2-0.3-0.80.70.8-0.6-0.6-0.4-0.71.10.20.8-1.4
Seeking ratio, delayed vs. immediate footshock0.10.10.4-0.30.10.20.30.20.1-0.00.30.20.20.40.2-0.10.7-0.2-0.1
Distance traveled before self-admin0.10.10.6-0.30.40.4-0.0-0.1-0.10.20.8-0.2-0.2-0.10.0-0.00.5-0.6-0.1
Distance traveled after self-admin1.31.63.3-1.31.61.60.90.91.1-0.91.60.90.90.5-0.4-1.71.8-1.61.5
Extensor digitorum longus weight4.517.627.0-4.14.94.83.73.94.0-4.53.84.14.12.8-3.5-5.24.4-3.94.6
Bone: elastic displacement0.80.92.30.8-0.8-0.8-0.7-0.9-1.21.2-0.2-1.2-1.2-0.7-0.51.3-0.31.5-1.2
Bone: elastic work0.20.30.9-0.60.70.70.60.40.4-0.30.90.30.30.4-0.9-0.40.6-0.10.2
Bone: endosteal estimation2.14.56.8-2.32.32.32.12.42.5-2.61.32.52.52.1-1.5-2.21.4-1.61.8
Bone: endosteal perimeter1.22.53.9-1.61.51.51.41.62.0-1.80.82.02.01.3-0.5-1.91.2-1.71.7
Epididymis fat weight1.03.55.8-2.22.22.22.42.31.7-2.02.01.91.92.3-1.7-0.81.5-0.30.2
Delta time in closed arm before/after self-admin0.60.62.2-0.20.40.40.20.50.8-0.8-0.30.90.90.10.2-1.30.1-1.41.5
Delta time in open arm before/after self-admin1.71.62.6-1.31.61.61.51.51.4-1.41.61.31.31.2-1.4-0.61.3-0.10.0
Diff in mean of infusions in LGA sessions0.60.73.70.4-0.3-0.3-0.0-0.2-0.70.50.2-0.5-0.50.20.31.6-0.31.7-1.9
Delay discount exponential model param0.40.40.9-0.70.40.40.80.90.9-0.90.10.80.81.00.0-0.30.5-0.30.2
Extinction: sum of active levers before priming0.40.41.10.9-0.7-0.7-0.6-0.5-0.40.2-1.1-0.3-0.3-0.40.80.8-0.80.5-0.8
Active lever presses in extinction session 60.10.10.3-0.30.10.10.40.40.4-0.40.00.30.30.60.30.10.30.4-0.2
Bone: final force4.47.010.4-3.13.23.22.82.82.9-2.63.02.62.62.4-2.1-2.42.5-1.71.7
Bone: final moment3.86.19.1-2.93.03.02.72.72.7-2.42.92.42.42.4-2.1-2.12.3-1.31.4
Food consumed during 24 hour testing period1.21.62.5-1.51.61.61.21.21.5-1.11.51.21.20.9-0.9-1.21.3-1.10.8
Glucose0.10.10.30.1-0.4-0.3-0.2-0.4-0.30.50.1-0.5-0.5-0.3-0.20.3-0.10.4-0.2
Heart weight0.00.10.2-0.30.10.10.30.20.30.20.40.30.30.3-0.00.10.2-0.2-0.4
Delay discount hyperbolic model param0.10.10.3-0.3-0.00.10.40.50.4-0.5-0.20.40.40.60.3-0.00.2-0.10.0
Intermittent access intake day 1-15 change0.61.12.71.5-0.8-0.9-1.5-1.5-1.31.2-0.6-1.2-1.2-1.70.30.7-0.6-0.2-0.5
Intermittent access intake escalation0.71.43.01.5-0.9-1.0-1.6-1.6-1.41.4-0.6-1.4-1.4-1.70.40.9-0.70.0-0.6
Intermittent access intake escalation 21.31.53.61.6-0.9-1.0-1.7-1.7-1.41.4-0.7-1.4-1.4-1.90.60.8-1.0-0.2-0.5
Intermitt. access day 1 inactive lever presses0.20.71.51.0-0.6-0.5-1.0-0.9-0.60.7-0.5-0.7-0.7-1.11.21.0-0.8-0.2-0.9
Intermitt. access day 15 inactive lever presses0.10.20.6-0.30.60.50.30.40.5-0.50.40.50.50.30.2-0.60.8-0.50.5
Intermitt. access escalation Index0.20.30.7-0.80.50.50.70.70.6-0.60.50.60.60.8-0.70.30.20.1-0.6
Intermittent access day 1 total infusions0.61.01.9-1.30.90.91.21.11.1-1.00.91.11.11.4-0.8-0.91.10.30.6
Intermittent access day 15 total infusions0.00.00.10.2-0.0-0.1-0.3-0.3-0.30.30.1-0.2-0.2-0.2-0.10.10.30.3-0.2
Intermittent access terminal intake (last 3 days)0.10.10.2-0.30.40.30.30.20.2-0.20.50.20.20.3-0.4-0.10.30.2-0.1
Intermittent access total infusions0.91.11.8-1.31.11.11.21.01.0-0.91.31.01.01.2-0.7-0.91.3-0.00.6
Intermittent access day 1 locomotion0.40.51.1-0.90.60.60.80.70.7-0.60.70.60.61.1-0.9-0.20.40.6-0.2
Intermittent access day 15 total locomotion0.20.31.60.2-0.2-0.3-0.1-0.3-0.40.40.2-0.4-0.40.0-0.11.0-0.31.2-1.3
Intermittent access total locomotion0.40.51.1-0.80.60.60.90.70.5-0.60.80.50.51.1-0.80.20.31.1-0.7
Intermittent access standard deviation0.51.02.0-0.61.31.20.50.50.8-0.71.30.80.80.1-1.4-1.11.2-1.40.9
Left kidney weight2.19.815.4-3.83.93.83.33.33.3-3.13.43.03.02.7-2.6-2.93.2-2.02.1
Right kidney weight2.611.818.0-4.14.24.13.83.73.5-3.53.93.33.33.3-3.2-2.83.7-1.61.7
Cocaine induced anxiety0.20.30.70.5-0.4-0.4-0.6-0.5-0.40.3-0.5-0.4-0.4-0.50.80.7-0.2-0.3-0.8
Post-drug Anxiety0.70.82.10.6-0.7-0.7-0.7-0.8-0.90.9-0.2-1.0-1.0-0.60.41.4-0.41.2-1.5
Baseline Anxiety0.20.31.6-0.50.20.30.40.1-0.10.31.0-0.3-0.30.3-0.9-0.00.41.30.0
Tail length0.62.25.2-1.91.81.81.61.31.3-1.12.10.90.91.2-2.3-1.51.50.31.2
Length with tail0.10.51.8-0.90.50.50.60.40.4-0.00.80.10.10.5-1.3-1.10.30.61.1
Length without tail0.41.42.61.2-1.5-1.6-1.2-1.4-1.31.6-1.1-1.3-1.3-1.10.90.3-1.10.40.2
Times rat made contact with spout1.21.45.3-0.91.11.20.60.61.1-0.80.90.90.90.1-0.2-1.71.4-2.31.5
Lifetime Intake1.31.62.9-1.61.31.31.51.31.3-1.11.51.21.21.5-0.7-1.21.7-0.10.9
Liver weight, left0.30.41.8-0.2-0.6-0.80.10.30.5-0.4-1.10.40.40.70.70.6-1.30.4-0.7
Liver weight, right0.20.31.1-0.1-0.2-0.50.10.40.4-0.8-1.00.60.60.60.5-0.2-0.6-0.30.4
Locomotor activity0.10.20.7-0.10.20.20.40.60.1-0.6-0.10.40.40.6-0.80.2-0.30.5-0.3
Locomotor testing distance0.20.30.9-0.40.50.50.70.70.4-0.70.40.50.50.7-0.90.00.00.3-0.3
Locomotor testing rearing0.10.20.60.0-0.2-0.30.40.4-0.2-0.5-0.40.30.30.7-0.20.4-0.70.6-0.4
Locomotion in novel chamber0.71.02.5-1.30.70.81.41.30.8-1.00.71.11.11.6-0.60.30.70.6-0.8
Locomotion in novel chamber post-restriction0.50.84.40.2-0.5-0.60.1-0.0-0.50.4-0.1-0.5-0.50.5-0.11.8-0.42.0-2.1
Fecal boli incidents, locomotor time 10.30.41.90.5-1.0-1.0-0.2-0.2-0.4-0.0-1.40.10.10.31.20.2-0.8-0.40.0
Change in fecal boli incidents, locomotor task0.70.72.6-0.90.80.70.90.50.10.21.60.10.10.7-1.40.20.41.6-0.6
Time >=10cm from walls, locomotor time 10.30.41.8-0.60.50.60.40.30.6-0.20.60.30.30.40.0-0.81.3-0.60.8
Bouts of movement, locomotor time 12.83.25.21.8-2.2-2.3-1.8-1.7-1.31.6-2.1-1.5-1.5-1.22.22.3-1.61.0-2.0
Total resting periods, locomotor time 13.33.66.02.0-2.3-2.5-1.9-1.8-1.51.6-2.4-1.6-1.6-1.32.32.2-2.01.0-1.8
Rest time, locomotor task time 11.01.32.31.2-1.4-1.5-1.5-1.4-1.01.2-1.5-1.1-1.1-1.31.00.1-1.1-0.00.5
Distance moved, locomotor task time 11.01.62.7-1.31.51.51.61.51.2-1.31.61.11.11.3-1.6-0.10.90.3-0.5
Vertical activity count, locomotor time 10.81.95.1-1.52.12.11.41.31.2-1.12.30.90.90.8-1.7-0.51.8-0.4-0.1
Time >=10cm from walls, locomotor time 21.21.84.3-1.31.51.61.11.11.3-1.01.40.90.90.8-0.4-1.82.1-1.41.8
Bouts of movement, locomotor time 20.71.13.2-0.70.30.30.91.21.2-1.6-0.71.81.81.4-0.1-0.80.3-1.10.8
Total resting periods, locomotor time 20.81.43.6-0.90.50.51.01.31.3-1.7-0.51.91.91.5-0.3-1.00.4-1.21.0
Rest time, locomotor task time 20.00.10.3-0.2-0.0-0.10.0-0.1-0.10.30.2-0.2-0.20.1-0.6-0.1-0.00.50.1
Distance moved, locomotor task time 20.30.41.4-0.20.91.0-0.10.10.4-0.40.70.20.2-0.5-0.4-0.40.9-1.20.4
Vertical activity count, locomotor time 20.30.41.3-0.20.91.0-0.2-0.10.10.21.2-0.4-0.4-0.6-1.00.10.8-0.3-0.2
Light reinforcement 10.10.31.7-0.0-0.9-0.60.20.10.1-0.0-0.4-0.1-0.10.6-0.60.7-0.51.3-0.7
Light reinforcement 20.10.20.7-0.4-0.1-0.20.40.40.3-0.2-0.00.20.20.8-0.10.5-0.40.8-0.7
Bone: marrow area1.84.06.2-2.12.22.12.02.22.4-2.51.22.32.31.9-1.4-2.01.3-1.51.7
Bone: maximum diameter2.44.66.7-2.52.42.42.32.42.6-2.32.02.42.42.2-1.5-2.01.7-1.21.4
Bone: maximum force3.56.29.6-2.93.13.12.62.62.7-2.52.92.42.42.1-2.2-2.42.3-1.61.7
Bone: maximum moment3.05.28.2-2.72.92.82.52.42.5-2.32.72.22.22.1-2.1-2.02.0-1.21.3
Mean time between licks in bursts0.10.41.50.4-0.8-0.8-0.4-0.30.00.3-0.90.00.0-0.21.20.7-0.7-0.4-0.7
Mean num. licks in bursts5.17.911.0-3.33.03.13.23.13.0-2.72.92.92.92.8-2.7-2.72.8-1.32.0
Cd content in liver1.41.58.80.2-1.1-1.00.2-0.1-0.70.6-0.4-0.7-0.70.7-1.02.0-1.13.0-2.1
Co content in liver0.70.81.80.30.20.2-0.4-0.8-0.91.31.0-1.3-1.3-0.9-0.70.80.41.1-1.0
Cu content in liver0.81.02.3-1.01.41.51.11.00.6-1.01.50.50.50.9-1.4-0.21.20.3-0.2
Fe content in liver0.50.61.70.6-0.1-0.1-0.6-0.8-0.90.80.2-1.1-1.1-0.80.21.2-0.20.7-1.3
K content in liver0.30.30.5-0.60.60.60.60.60.7-0.60.50.60.60.7-0.20.20.5-0.1-0.5
Mg content in liver0.30.31.1-0.40.40.30.60.70.7-1.1-0.10.80.80.8-0.0-0.20.2-0.50.1
Mn content in liver0.50.61.0-0.81.00.80.70.80.8-0.90.41.01.00.7-0.3-0.60.8-0.90.4
Na content in liver4.65.08.6-2.22.12.21.92.22.6-2.61.32.72.71.80.3-2.42.2-2.92.0
Rb content in liver2.63.09.31.0-1.4-1.4-0.5-1.1-1.71.7-0.1-2.0-2.0-0.4-0.32.8-1.43.0-2.9
Se content in liver0.10.21.2-0.20.40.40.10.10.3-0.30.20.30.3-0.00.4-0.30.5-1.10.2
Sr content in liver0.90.81.2-0.91.01.00.91.01.1-1.10.51.11.10.8-0.6-0.70.7-0.60.6
Zn content in liver2.62.84.9-2.01.51.62.02.22.2-2.11.02.02.02.2-1.4-1.11.1-0.50.6
Bone: minimum diameter2.34.25.4-2.22.22.12.02.22.3-2.31.62.32.31.9-1.4-2.31.6-1.52.0
Time in familiar zone, hab. session 11.11.12.80.9-0.5-0.5-0.8-1.0-1.21.30.1-1.3-1.3-0.9-0.01.5-0.31.3-1.7
Time in novel zone, hab. session 11.51.56.8-0.90.40.40.91.01.1-1.2-0.11.31.31.1-0.7-2.30.4-1.02.6
Total zone transitions, hab. session 12.13.07.4-2.01.92.01.91.61.4-1.02.41.31.31.5-2.7-1.32.3-0.00.8
Total locomotion distance, hab. session 15.37.515.6-3.23.23.23.12.92.7-2.23.42.42.42.7-4.0-1.92.70.31.1
Locomotion velocity, hab. session 14.46.212.4-3.02.82.93.02.82.5-2.23.02.32.32.7-3.5-1.32.30.40.5
Time in familiar zone, hab. session 20.30.31.3-0.70.50.60.50.50.5-0.20.80.40.40.4-1.2-0.30.7-0.10.0
Time in novel zone, hab. session 20.00.00.10.1-0.2-0.20.00.0-0.1-0.1-0.30.00.00.10.40.1-0.40.4-0.1
Total zone transitions, hab. session 22.12.76.1-1.81.81.81.91.71.4-1.32.11.41.41.6-2.5-1.21.80.40.8
Total locomotion distance, hab. session 22.83.67.4-2.22.32.32.11.91.8-1.42.61.51.51.7-2.7-1.42.00.20.9
Locomotion velocity, hab. session 23.34.47.6-2.42.52.52.32.22.1-1.82.71.81.82.0-2.8-1.62.20.01.1
Novel to familiar place preference ratio1.01.12.01.2-0.8-0.8-1.2-1.1-1.01.2-0.6-1.2-1.2-1.20.71.4-0.90.7-1.4
Novelty place preference1.21.32.01.4-0.9-0.9-1.3-1.3-1.21.4-0.6-1.3-1.3-1.40.71.3-0.70.6-1.2
Time in novel zone, NPP test1.11.11.91.2-0.8-0.8-1.1-1.2-1.11.3-0.5-1.2-1.2-1.10.31.3-0.71.0-1.4
Total zone transitions, NPP test1.42.03.4-1.61.51.51.61.41.4-1.11.81.21.21.3-1.9-1.31.5-0.10.9
Total locomotion distance, NPP test1.41.94.3-1.61.81.81.41.31.4-0.92.01.11.11.1-2.1-0.91.30.00.4
Locomotion velocity, NPP test1.01.53.5-1.51.61.61.21.11.3-0.81.90.90.90.9-1.5-0.91.3-0.30.5
Intraocular pressure0.30.40.9-0.60.60.70.60.70.8-0.70.20.70.70.60.1-0.90.2-0.50.9
Delta distance traveled before/after self-admin0.90.92.3-0.90.90.90.80.91.1-1.00.51.01.00.7-0.4-1.51.0-0.61.5
Delta ambulatory time before/after self-admin1.01.33.1-1.01.21.20.91.01.2-1.10.81.11.10.6-0.4-1.81.2-0.91.7
Parametrial fat weight2.55.911.0-3.22.72.53.32.92.2-2.53.02.12.13.2-2.0-1.02.50.70.1
Pavlov. Cond. lever latency1.62.04.60.8-0.3-0.3-0.9-1.3-1.72.00.9-1.9-1.9-1.4-1.51.3-0.12.2-1.4
Pavlov. Cond. magazine entry latency4.96.311.8-2.41.81.92.42.93.3-3.40.43.33.32.80.9-2.31.3-3.02.1
Pavlov. Cond. change in total contacts2.62.810.3-0.80.60.70.71.31.9-2.1-0.72.12.11.11.8-2.00.3-3.22.2
Pavlov. Cond. index score2.93.77.7-1.50.91.01.52.12.4-2.8-0.52.62.62.01.5-1.80.4-2.71.9
Pavlov. Cond. latency score2.63.26.9-1.40.91.01.52.02.3-2.6-0.42.52.52.01.3-1.60.5-2.41.6
Pavlov. Cond. lever contacts3.13.77.4-1.51.01.01.62.12.4-2.7-0.32.62.62.01.1-2.00.7-2.62.0
Pavlov. Cond. magazine entry number2.93.68.81.4-1.0-1.0-1.4-1.9-2.42.50.3-2.5-2.5-1.8-1.42.0-0.63.0-2.0
Pavlov. Cond. intertrial magazine entries1.72.05.41.1-0.9-1.0-0.9-1.2-1.51.7-0.1-1.7-1.7-0.9-0.12.0-1.12.3-2.2
Pavlov. Cond. lever-magazine prob. diff.3.54.39.0-1.71.11.11.82.32.7-3.0-0.42.92.92.31.4-1.90.6-2.81.9
Pavlov. Cond. response bias3.34.110.3-1.40.91.01.42.02.5-2.7-0.52.72.71.81.7-2.30.7-3.22.4
Pavlov. Cond. lever latency1.21.62.91.7-1.1-1.2-1.6-1.6-1.71.2-1.1-1.5-1.5-1.71.00.6-0.80.1-0.2
Pavlov. Cond. magazine entry latency0.70.82.51.0-1.1-1.1-1.0-0.8-0.50.3-1.5-0.4-0.4-0.81.60.3-1.1-0.40.0
Pavlov. Cond. change in total contacts0.40.62.9-0.50.10.10.70.50.3-0.10.50.00.00.9-0.91.2-0.51.7-1.5
Pavlov. Cond. index score0.10.10.4-0.3-0.00.00.40.40.6-0.5-0.10.50.50.60.20.3-0.40.2-0.4
Pavlov. Cond. latency score0.10.10.3-0.30.00.10.30.40.6-0.5-0.10.50.50.50.30.0-0.2-0.0-0.2
Pavlov. Cond. lever contacts1.11.63.0-1.61.11.21.61.61.7-1.31.01.51.51.7-0.9-0.60.8-0.20.2
Pavlov. Cond. magazine entry number1.51.83.2-1.51.61.61.41.31.2-1.01.71.21.21.1-1.6-1.41.8-0.61.1
Pavlov. Cond. intertrial magazine entries2.64.05.7-2.22.12.02.32.42.1-2.41.72.22.22.3-1.7-1.61.7-0.91.2
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.1-0.2-0.10.20.20.4-0.3-0.40.30.30.40.40.3-0.60.1-0.4
Pavlov. Cond. response bias0.30.41.0-0.70.30.30.80.80.9-0.70.20.80.81.0-0.10.2-0.10.2-0.4
Time in closed arm before self-admin0.00.10.3-0.30.10.10.20.10.10.00.30.10.10.3-0.50.10.60.0-0.2
Time in closed arm after self-admin0.30.30.60.5-0.5-0.5-0.6-0.6-0.70.8-0.1-0.6-0.6-0.6-0.20.4-0.70.6-0.4
Time in open arm before self-admin1.01.12.31.1-1.2-1.2-1.1-1.0-1.00.9-1.3-1.0-1.0-0.91.50.8-1.20.2-0.5
Time in open arm after self-admin1.71.82.7-1.21.61.61.21.31.5-1.61.11.41.40.8-0.8-1.31.6-1.51.0
Bone: periosteal estimation3.67.59.8-3.13.13.12.82.93.1-2.92.52.92.92.5-2.1-2.92.4-1.92.3
Bone: periosteal perimeter2.23.85.7-2.31.81.82.12.22.4-2.11.42.32.32.1-1.2-1.91.6-1.11.5
Bone: post-yield work3.45.07.9-2.62.52.42.82.82.5-2.81.82.42.42.8-2.1-1.31.2-0.00.7
Progressive ratio test 1 active lever presses0.40.51.2-1.00.60.60.80.80.9-0.80.30.80.81.1-0.6-0.70.8-0.20.4
Progressive ratio test 1 breakpoint0.40.51.0-1.00.50.50.70.70.8-0.80.20.80.81.0-0.6-0.70.6-0.20.4
Progressive ratio test 1 inactive lever presses0.10.10.3-0.3-0.1-0.00.10.20.5-0.3-0.30.40.40.5-0.10.10.20.2-0.2
Progressive ratio test 2 active lever presses0.10.10.3-0.3-0.1-0.10.20.20.1-0.2-0.30.20.20.50.5-0.40.10.10.4
Progressive ratio test 2 breakpoint0.10.10.3-0.3-0.2-0.10.20.20.1-0.1-0.30.20.20.50.5-0.30.10.20.4
Progressive ratio test 2 inactive lever presses0.20.30.7-0.70.50.50.60.70.6-0.60.40.70.70.90.3-0.50.3-0.00.3
Incentive Sensitization - Responses0.10.21.30.0-0.3-0.2-0.0-0.0-0.2-0.0-0.50.00.00.11.1-0.5-0.1-0.20.7
Incentive Sensitization - Breakpoint0.10.11.1-0.1-0.3-0.20.10.1-0.1-0.1-0.40.10.10.21.1-0.4-0.0-0.10.7
Sum of active levers in priming session hrs 5-60.60.62.30.5-1.0-1.0-0.10.0-0.2-0.2-1.50.20.20.41.20.8-1.20.7-0.7
Progressive ratio0.20.31.9-0.50.30.30.50.40.3-0.10.60.10.10.6-0.30.6-0.11.4-0.8
Food seeking constrained by brief footshock0.91.11.81.2-1.0-0.8-1.2-1.2-0.91.2-0.8-1.2-1.2-1.10.71.3-1.30.4-1.2
Seeking ratio, punishment vs. effort0.30.43.40.1-0.10.1-0.2-0.10.2-0.2-0.40.20.2-0.30.4-0.90.1-1.81.0
Retroperitoneal fat weight1.56.516.8-3.22.52.23.83.52.1-2.82.62.52.54.1-1.7-0.41.51.5-0.6
Reaction time number correct0.30.61.30.6-1.2-1.1-0.6-0.5-0.40.4-1.1-0.5-0.5-0.30.80.5-0.91.1-0.2
Reaction time mean minus median0.10.21.0-0.10.50.40.30.2-0.2-0.30.50.10.10.2-1.00.40.70.1-0.6
Reaction time mean minus median AUC0.20.41.60.3-0.0-0.20.1-0.1-0.80.10.1-0.3-0.30.2-1.21.10.11.3-1.2
Reaction time num false alarms0.91.23.11.4-0.5-0.6-1.6-1.4-1.11.3-0.7-1.3-1.3-1.80.80.9-0.9-0.1-0.7
Reaction time num false alarms AUC0.40.61.51.1-0.4-0.4-1.2-0.9-0.70.9-0.8-0.9-0.9-1.20.80.6-0.8-0.3-0.3
Reaction time trials correct on left0.30.61.30.6-1.2-1.1-0.6-0.5-0.40.4-1.1-0.5-0.5-0.30.80.5-0.91.1-0.2
Reaction time trials on left0.30.61.30.6-1.1-1.1-0.6-0.5-0.40.3-1.2-0.5-0.5-0.30.80.5-1.01.1-0.2
Reaction time mean0.20.30.9-0.50.90.70.70.70.2-0.70.60.50.50.7-0.60.10.6-0.1-0.3
Reaction time mean AUC0.10.10.3-0.20.60.30.50.50.0-0.50.10.40.40.6-0.10.10.3-0.2-0.2
Median of all reaction times0.30.40.9-0.70.90.70.80.80.4-0.80.50.70.70.9-0.3-0.20.6-0.3-0.0
Reaction time omissions0.10.10.70.1-0.3-0.40.20.30.1-0.3-0.80.30.30.50.60.2-0.40.0-0.1
Reaction time false alarm rate0.30.41.30.70.20.1-0.9-0.7-0.40.7-0.2-0.6-0.6-1.10.40.2-0.2-1.0-0.1
Reaction time premature initiation rate1.11.53.4-1.01.51.40.91.01.0-1.11.11.01.00.5-1.2-1.81.3-1.51.8
Reaction time premature initiations0.30.62.8-0.40.70.60.40.50.6-0.70.30.60.60.2-0.6-1.50.6-0.91.7
Std. dev. reaction times0.20.31.2-0.40.80.60.70.5-0.0-0.50.70.30.30.6-1.10.20.70.3-0.4
Reaction time trials completed0.30.61.30.6-1.1-1.1-0.6-0.5-0.40.3-1.2-0.5-0.5-0.30.80.5-1.01.1-0.2
Reaction time trials AUC0.20.41.20.5-0.9-0.9-0.4-0.3-0.30.2-0.9-0.4-0.4-0.20.60.4-0.71.1-0.1
Run reversals in cocaine runway, females3.83.86.7-1.92.52.61.51.61.9-1.72.31.81.80.8-1.4-2.31.9-2.32.1
Run reversals in cocaine runway, males0.80.81.81.2-0.9-0.8-1.1-1.1-1.31.1-0.7-1.0-1.0-1.10.00.5-0.20.5-0.3
Latency to leave start box in cocaine runway0.30.43.3-0.2-0.2-0.10.2-0.00.00.50.3-0.4-0.40.3-0.80.8-0.21.8-0.9
Latency to leave start box in cocaine runway, F0.10.10.5-0.1-0.4-0.30.1-0.00.40.2-0.4-0.1-0.10.2-0.10.3-0.50.7-0.1
Latency to leave start box in cocaine runway, M0.60.64.0-0.10.10.10.3-0.1-0.60.60.8-0.6-0.60.1-0.80.90.22.0-1.2
Std. dev. time between licks in bursts0.40.61.3-0.70.10.20.70.91.2-1.0-0.21.11.11.00.90.3-0.0-0.5-0.5
Total sessions with >9 infusions5.66.810.2-3.22.72.73.02.92.7-2.62.62.72.73.0-1.7-2.72.7-0.72.1
Short access day 1 total inactive lever presses0.40.51.1-0.70.60.70.70.60.6-0.60.60.70.70.6-0.8-1.10.9-0.21.0
Short access day 10 total inactive lever presses0.82.03.21.6-1.6-1.6-1.8-1.7-1.21.5-1.5-1.4-1.4-1.71.60.8-1.30.2-0.4
Short access day 1 total infusions1.41.83.6-1.71.31.41.41.31.4-1.21.41.21.21.4-0.8-1.91.2-0.31.8
Short access day 10 total infusions2.63.35.7-2.21.71.72.01.92.0-1.71.51.91.92.0-1.2-2.12.4-0.41.8
Short access total infusions3.54.47.0-2.62.22.22.42.22.2-2.02.22.12.12.3-1.3-2.22.5-0.41.8
Short access day 1 locomotion0.30.41.0-0.80.70.70.50.40.5-0.41.00.30.30.4-0.4-0.90.6-0.40.9
Short access day 10 total locomotion2.34.25.6-2.42.22.22.22.32.3-2.31.72.42.42.2-2.1-1.61.7-1.21.0
Short access total locomotion3.74.57.0-2.72.32.32.52.42.2-2.02.52.12.12.5-2.3-1.52.00.20.7
One hour access (0.3 mA shock)0.20.20.7-0.50.20.10.50.50.4-0.4-0.00.40.40.8-0.10.30.20.6-0.6
Compulsive drug intake0.10.20.4-0.30.10.00.40.50.3-0.4-0.30.40.40.60.20.3-0.70.4-0.4
One hour access (shock baseline)0.10.20.60.3-0.3-0.2-0.3-0.4-0.40.40.0-0.3-0.3-0.1-0.10.60.20.7-0.8
Social response proportion0.30.32.3-0.1-0.2-0.20.40.40.2-0.3-0.20.10.10.7-0.40.8-0.31.5-1.0
Social responses0.40.51.30.4-1.0-1.0-0.4-0.3-0.00.2-1.1-0.2-0.20.10.11.1-1.01.1-1.1
Social time0.81.02.21.0-1.3-1.3-0.8-1.0-0.91.1-0.9-0.9-0.9-0.60.21.0-1.21.5-0.9
Soleus weight2.26.513.2-2.83.63.52.72.52.3-2.33.42.02.02.0-3.0-2.02.9-0.71.2
Bone: stiffness2.13.46.2-2.12.52.51.71.72.0-1.62.51.61.61.2-1.5-1.91.8-1.51.3
Tibialis anterior weight6.221.029.3-5.15.45.44.74.64.6-4.45.24.24.23.8-4.6-4.75.2-2.73.7
Time to tail flick, vehicle, before self-admin0.10.10.6-0.20.50.50.30.40.3-0.30.50.30.30.3-0.80.0-0.1-0.1-0.2
Time to tail flick, vehicle, after self-admin1.92.65.11.9-2.1-2.1-1.6-1.5-1.81.4-2.2-1.3-1.3-1.11.31.2-2.30.8-0.7
Time to tail flick, test, before self-admin0.10.10.50.3-0.0-0.0-0.3-0.2-0.10.1-0.1-0.0-0.0-0.4-0.50.1-0.3-0.7-0.2
Time to tail flick, test, after self-admin0.60.73.51.0-0.5-0.5-0.8-0.5-0.1-0.0-1.20.00.0-0.81.5-0.3-0.3-1.90.6
Delta time to tail flick, vehicle, before/after SA0.20.20.60.5-0.7-0.7-0.2-0.2-0.40.2-0.8-0.2-0.2-0.10.80.2-0.50.5-0.1
Delta time to tail flick, test, before/after SA0.20.30.6-0.30.30.30.30.30.5-0.6-0.00.50.50.30.7-0.60.7-0.80.7
Tibia length0.10.31.1-0.20.30.40.10.0-0.10.10.7-0.3-0.30.0-0.90.7-0.11.1-1.0
Ambulatory time before self-admin0.20.30.80.1-0.0-0.0-0.5-0.7-0.70.90.7-0.9-0.9-0.60.10.50.2-0.2-0.5
Ambulatory time after self-admin1.31.52.9-1.31.61.60.70.71.0-0.71.70.70.70.2-0.1-1.71.7-1.61.5
Bone: tissue strength0.10.10.4-0.10.40.3-0.1-0.10.1-0.10.30.00.0-0.2-0.1-0.4-0.0-0.60.4
Total heroin consumption0.30.41.20.3-0.8-0.8-0.00.0-0.20.0-1.0-0.1-0.10.60.70.7-0.71.1-0.6
Bone: trabecular number0.61.01.8-1.31.31.31.00.91.0-0.81.40.80.80.7-1.2-1.01.0-0.30.7
Bone: trabecular spacing0.60.83.01.0-1.3-1.3-0.6-0.4-0.4-0.0-1.7-0.0-0.0-0.11.70.6-1.0-0.3-0.3
Bone: trabecular thickness2.22.87.7-2.02.12.22.01.61.2-0.92.80.70.71.6-2.5-0.21.61.4-0.5
Bone: trabecular tissue density0.10.10.20.2-0.2-0.0-0.2-0.3-0.30.40.2-0.4-0.4-0.4-0.30.30.00.3-0.4
Water consumed over 24 hours1.01.33.41.3-0.7-0.7-1.5-1.4-0.80.9-1.0-0.9-0.9-1.81.3-0.8-0.2-1.71.3
Number of responses in last shaping day0.30.31.3-0.60.40.40.20.30.5-0.40.20.40.40.3-0.5-1.10.2-0.11.2