Hub : Genes

Cgnl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Cgnl1 0.03 0.02 4.5e-03 0 0.01 0 0 2.3e-01 5.6e-02 7.5e-02 1.1e-01
2 Brain alternative TSS NM_001389277.1 0.02 0.02 9.0e-03 0.02 0.01 0.02 0.01 3.5e-03 3.4e-02 8.2e-03 2.1e-02
3 PL alternative TSS NM_001389277.1 0.02 0.02 7.0e-03 0.02 0.02 0.02 0.02 1.2e-03 4.0e-03 2.1e-03 1.6e-03
4 PL isoform ratio NM_001389277.1 0.02 0.02 2.4e-03 0.03 0.02 0.02 0.02 6.2e-04 2.9e-03 3.6e-03 2.5e-03
5 BLA gene expression Cgnl1 0.12 0.08 1.3e-04 0.07 0.06 0.06 0.06 9.4e-05 4.7e-04 5.2e-04 5.7e-04
6 pVTA gene expression Cgnl1 0.13 0.08 1.5e-03 0.06 0.05 0.05 0.05 1.1e-03 3.0e-03 4.6e-03 2.7e-03
7 Adipose gene expression Cgnl1 0.55 0.18 0.0e+00 0.33 0.37 0.38 0.38 3.7e-38 1.2e-42 9.9e-44 7.4e-44
8 PL isoform ratio XM_039081511.1 0.02 0.02 9.2e-03 0.01 0.01 0 0.01 4.1e-02 7.5e-03 2.6e-01 2.5e-02
9 Brain gene expression Cgnl1 0.29 0.13 0.0e+00 0.2 0.2 0.2 0.21 7.6e-19 1.5e-18 3.6e-18 3.9e-19
10 Adipose mRNA stability Cgnl1 0.1 0.07 1.0e-08 0.04 0.06 0.06 0.06 8.2e-06 3.1e-07 3.1e-07 1.6e-07
11 NAcc gene expression Cgnl1 0.24 0.11 0.0e+00 0.15 0.16 0.16 0.16 2.2e-17 1.5e-18 2.5e-18 3.6e-18
12 OFC gene expression Cgnl1 0.63 0.17 8.6e-08 0.15 0.28 0.27 0.28 1.8e-04 2.8e-07 3.5e-07 1.9e-07
13 PL gene expression Cgnl1 0.28 0.11 0.0e+00 0.16 0.18 0.18 0.18 1.2e-17 1.5e-19 1.7e-19 1.8e-19
14 IL gene expression Cgnl1 0.36 0.19 2.3e-03 0.03 0.08 0.08 0.07 8.5e-02 7.2e-03 5.3e-03 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.30.41.10.30.70.70.70.10.2-1.00.9-0.1-1.0-0.5-0.7-0.50.7
Area under the delay curve1.21.33.2-0.60.00.10.11.21.2-0.90.6-1.2-1.2-1.4-1.8-1.51.8
BMI with tail3.812.220.8-4.6-4.1-4.1-4.14.14.03.1-3.2-4.02.4-3.2-1.8-2.82.1
BMI without tail1.42.86.1-1.8-2.3-2.3-2.31.00.82.5-2.3-1.12.4-0.20.6-0.0-0.5
Body weight3.414.324.9-5.0-4.1-4.2-4.24.54.43.1-3.2-4.52.3-3.7-2.4-3.42.7
Weight adjusted by age3.53.97.8-2.3-2.8-2.7-2.71.31.32.8-2.7-1.32.5-0.50.3-0.2-0.1
Bone surface0.10.20.3-0.5-0.5-0.5-0.50.40.40.4-0.4-0.30.3-0.4-0.1-0.30.2
Bone volume0.10.10.2-0.3-0.2-0.2-0.20.40.40.0-0.0-0.4-0.0-0.5-0.3-0.40.4
Breakpoint value in progressive ratio session0.20.20.5-0.6-0.4-0.3-0.30.70.60.5-0.3-0.50.4-0.4-0.4-0.50.3
Number of licking bursts1.51.72.81.71.41.41.4-1.6-1.6-0.70.91.6-0.41.41.11.3-1.2
Context. condit. distance diff. score0.70.82.30.61.01.11.1-0.0-0.1-1.41.3-0.2-1.5-0.4-0.9-0.50.9
Locomotion velocity, session 11.61.83.6-0.5-1.4-1.4-1.4-0.5-0.51.8-1.80.51.91.11.61.3-1.4
Locomotion distance, session 10.60.81.51.00.60.50.5-1.2-1.2-0.20.21.2-0.01.20.91.1-0.9
Locomotion velocity, session 20.30.30.7-0.1-0.5-0.6-0.6-0.2-0.20.7-0.60.10.80.40.80.5-0.7
Locomotion distance, session 20.20.30.5-0.1-0.5-0.5-0.5-0.3-0.30.6-0.70.30.70.60.70.6-0.7
Locomotion velocity, session 31.82.14.71.10.10.10.1-1.9-2.00.3-0.61.90.62.11.82.2-1.8
Locomotion distance, session 31.71.93.21.81.61.61.6-1.5-1.6-1.31.21.5-1.11.30.51.1-0.6
Stereotopy head waving bouts, day 30.30.30.8-0.6-0.9-0.9-0.90.30.30.7-0.9-0.10.7-0.00.20.1-0.2
Stereotopy head waving duration, day 30.40.51.1-0.7-1.0-1.1-1.10.20.21.0-1.0-0.11.00.10.50.2-0.4
Locomotion velocity, session 71.31.42.41.61.41.41.4-1.4-1.4-1.21.11.3-0.91.00.60.9-0.6
Locomotion distance, session 71.62.03.41.81.41.41.4-1.8-1.8-1.11.01.8-0.81.61.01.5-1.0
Stereotopy head waving bouts, day 70.70.71.8-0.5-1.0-1.0-1.0-0.1-0.11.3-1.20.11.40.51.00.6-0.9
Stereotopy head waving duration, day 70.91.12.4-0.3-1.0-1.0-1.0-0.5-0.51.4-1.30.41.60.91.41.0-1.3
Locomotion velocity, session 80.50.61.4-0.2-0.8-0.7-0.7-0.5-0.51.0-1.00.31.20.71.10.8-1.0
Locomotion distance, session 80.30.50.80.90.80.90.9-0.7-0.8-0.90.70.5-0.80.50.10.4-0.1
Degree of sensitization distance0.10.10.30.40.20.20.2-0.4-0.4-0.10.10.50.10.40.50.4-0.5
Degree of sensitization stereotypy0.50.51.3-0.4-0.8-0.8-0.8-0.1-0.11.1-1.00.01.10.40.80.5-0.7
Conditioned locomotion1.11.33.2-0.50.20.20.21.21.1-1.00.7-1.1-1.3-1.4-1.8-1.41.8
Cocaine response after cond. corrected1.51.74.1-1.2-1.7-1.7-1.70.30.32.0-1.9-0.42.00.30.90.4-0.8
Cocaine response after cond. not corrected0.80.92.1-0.8-1.2-1.2-1.20.20.11.4-1.4-0.21.40.30.70.4-0.6
Cocaine response before conditioning0.81.02.60.71.21.21.2-0.0-0.0-1.51.4-0.1-1.6-0.4-1.0-0.50.9
Saline control response1.01.32.41.10.50.50.5-1.5-1.50.0-0.01.40.41.51.51.5-1.5
Bone: connectivity density0.50.91.51.21.11.11.1-1.0-1.0-1.00.91.2-1.00.70.20.6-0.3
Bone: cortical apparent density0.40.51.01.00.90.90.9-0.9-0.9-0.60.70.8-0.50.70.30.6-0.4
Bone: cortical area0.00.00.1-0.1-0.0-0.0-0.00.10.2-0.10.1-0.1-0.1-0.2-0.2-0.20.2
Bone: cortical porosity0.50.51.20.61.11.01.0-0.0-0.1-0.91.1-0.1-0.9-0.3-0.5-0.40.4
Bone: cortical porosity1.01.12.60.71.41.41.40.20.1-1.51.6-0.2-1.4-0.6-0.9-0.80.8
Bone: cortical thickness0.50.91.81.11.31.31.3-0.5-0.5-1.31.30.6-1.20.2-0.30.00.2
Bone: cortical thickness0.50.50.91.00.90.90.9-0.8-0.8-0.60.80.8-0.50.60.30.5-0.4
Bone: cortical tissue density0.40.51.01.00.90.90.9-0.9-0.9-0.60.60.8-0.50.70.30.6-0.4
Condit. Reinf. active minus inactive responses1.31.53.2-0.70.10.20.21.41.4-0.70.8-1.5-1.0-1.7-1.8-1.81.7
Condit. Reinf. active-inactive response ratio1.51.63.2-0.10.80.80.81.11.1-1.31.3-1.1-1.5-1.5-1.8-1.61.7
Condit. Reinf. active responses0.50.61.1-0.9-0.5-0.4-0.41.01.00.3-0.2-1.00.2-1.0-0.7-1.00.7
Condit. Reinf. inactive responses0.91.12.8-0.4-1.0-0.9-0.9-0.4-0.51.5-1.30.61.70.81.40.9-1.3
Incentive salience index mean1.61.94.0-0.90.00.10.11.71.6-0.70.7-1.7-1.0-1.9-2.0-2.02.0
Condit. Reinf. lever presses0.81.02.3-0.60.10.20.21.11.1-0.60.6-1.2-0.9-1.4-1.5-1.41.5
Condit. Reinf. active minus inactive responses2.02.54.4-2.1-1.8-1.8-1.81.81.91.4-1.4-1.81.1-1.5-0.8-1.40.9
Condit. Reinf. active-inactive response ratio0.90.91.5-1.2-1.1-1.1-1.11.11.20.8-0.7-1.10.7-1.0-0.4-0.80.5
Condit. Reinf. active responses1.82.54.5-2.0-1.4-1.4-1.42.02.00.8-0.8-2.10.4-1.9-1.4-1.81.6
Condit. Reinf. inactive responses0.60.71.7-0.50.10.10.10.90.8-0.50.5-1.0-0.8-1.1-1.3-1.21.3
Condit. Reinf. lever presses0.30.41.00.50.80.90.9-0.0-0.0-0.91.00.0-0.9-0.3-0.5-0.40.4
Condit. Reinf. lever reinforcers received1.52.14.0-1.7-1.0-1.0-1.01.91.90.4-0.4-2.0-0.0-1.9-1.6-1.81.7
Conditioned reinforcement - actives0.20.20.30.40.20.20.2-0.6-0.5-0.10.00.50.00.50.50.5-0.5
Conditioned reinforcement - inactives0.30.40.70.60.40.40.4-0.8-0.80.10.10.70.20.80.80.7-0.9
Conditioned locomotion1.21.42.8-0.10.80.90.90.91.0-1.31.3-0.9-1.6-1.4-1.7-1.51.6
Patch foraging indifference point 0 sec0.30.50.9-0.1-0.6-0.6-0.6-0.4-0.60.8-1.00.60.80.80.80.9-0.8
Patch foraging indifference point AUC0.40.41.0-0.20.30.30.30.70.7-0.50.5-0.6-0.7-0.8-1.0-0.90.9
Delay disc. indifference point, 0s delay0.70.71.80.10.70.60.60.50.4-1.10.9-0.4-1.3-0.7-1.3-0.91.2
Delay disc. indifference point, 16s delay1.31.32.9-0.10.60.70.70.80.8-1.41.1-0.8-1.7-1.2-1.7-1.31.7
Delay disc. indifference point, 2s delay0.10.20.30.40.60.60.6-0.2-0.2-0.50.50.3-0.50.2-0.20.00.1
Delay disc. indifference point, 24s delay0.30.30.60.20.40.50.50.20.2-0.80.7-0.2-0.8-0.4-0.6-0.40.5
Delay disc. indifference point, 4s delay1.11.22.7-0.20.50.50.50.90.9-1.21.0-0.9-1.4-1.2-1.6-1.31.5
Delay disc. indifference point, 8s delay0.70.81.4-0.8-0.6-0.5-0.51.21.2-0.1-0.1-1.1-0.4-1.2-1.1-1.11.2
Indifference point function ln k0.50.71.4-0.5-1.1-1.0-1.0-0.1-0.11.2-1.20.21.20.40.80.6-0.7
Indifference point function log k0.50.71.4-0.5-1.1-1.0-1.0-0.1-0.11.2-1.20.21.20.40.80.6-0.7
Patch foraging total patch changes 0 sec0.30.61.2-0.2-0.7-0.7-0.7-0.4-0.50.9-1.10.50.90.80.80.9-0.8
Patch foraging total patch changes 12 sec0.10.10.20.30.50.40.4-0.1-0.2-0.40.30.3-0.40.2-0.10.10.0
Patch foraging total patch changes 18 sec0.00.00.00.00.1-0.0-0.0-0.0-0.10.1-0.10.10.10.20.00.2-0.0
Patch foraging total patch changes 24 sec0.20.20.50.0-0.1-0.2-0.2-0.5-0.60.4-0.60.50.50.70.60.7-0.6
Patch foraging total patch changes 6 sec0.10.10.3-0.4-0.4-0.4-0.40.20.20.4-0.5-0.20.30.0-0.00.00.0
Patch foraging time to switch 0 sec0.81.22.61.31.61.61.6-0.7-0.7-1.41.60.6-1.20.3-0.00.1-0.1
Patch foraging water rate 0 sec1.21.94.3-1.6-2.1-2.0-2.00.90.91.8-2.0-0.81.5-0.30.1-0.10.0
Patch foraging water rate 12 sec2.33.58.5-1.8-2.5-2.4-2.40.30.42.9-2.9-0.32.80.51.20.7-1.0
Patch foraging water rate 18 sec0.30.40.9-0.5-0.7-0.7-0.7-0.1-0.11.0-1.0-0.10.90.30.60.3-0.4
Patch foraging water rate 24 sec0.20.30.6-0.0-0.2-0.2-0.2-0.5-0.50.8-0.70.60.70.70.70.6-0.6
Patch foraging water rate 6 sec0.60.81.8-1.0-1.3-1.3-1.30.40.41.3-1.4-0.31.2-0.10.30.1-0.2
Seeking ratio, delayed vs. immediate footshock0.50.61.2-0.9-0.9-1.1-1.10.80.90.9-0.8-0.70.8-0.5-0.1-0.30.1
Distance traveled before self-admin0.00.00.2-0.0-0.1-0.1-0.1-0.10.00.2-0.1-0.10.30.00.40.1-0.3
Distance traveled after self-admin1.41.54.1-0.8-1.3-1.4-1.40.0-0.11.9-1.70.12.00.61.30.8-1.3
Extensor digitorum longus weight4.919.433.7-5.8-5.7-5.7-5.74.34.34.8-4.9-4.34.0-3.1-1.3-2.61.7
Bone: elastic displacement0.50.50.8-0.9-0.6-0.6-0.60.90.90.2-0.3-0.90.0-0.9-0.8-0.80.8
Bone: elastic work0.91.12.5-0.8-0.1-0.1-0.11.31.3-0.40.4-1.3-0.6-1.5-1.5-1.61.5
Bone: endosteal estimation1.22.55.2-2.0-2.3-2.2-2.21.21.22.0-2.1-1.11.8-0.70.1-0.40.1
Bone: endosteal perimeter2.34.78.3-2.9-2.7-2.7-2.72.32.32.0-2.2-2.31.6-1.8-1.0-1.61.2
Epididymis fat weight0.20.40.90.1-0.4-0.4-0.4-0.4-0.50.6-0.50.50.80.60.90.7-0.9
Delta time in closed arm before/after self-admin0.20.10.4-0.3-0.4-0.3-0.30.50.6-0.20.0-0.6-0.1-0.6-0.3-0.40.4
Delta time in open arm before/after self-admin2.22.14.11.71.31.31.3-1.9-2.0-0.50.71.8-0.21.81.41.6-1.5
Diff in mean of infusions in LGA sessions1.41.53.4-1.4-0.5-0.4-0.41.51.50.1-0.0-1.6-0.3-1.8-1.5-1.81.7
Delay discount exponential model param0.91.02.50.60.10.00.0-1.1-1.10.7-0.51.11.01.31.61.3-1.5
Extinction: sum of active levers before priming1.61.63.20.90.40.40.4-1.4-1.50.7-0.41.61.01.81.71.7-1.8
Active lever presses in extinction session 60.00.00.10.10.00.10.1-0.1-0.10.20.00.10.30.10.30.1-0.4
Bone: final force0.60.91.6-1.3-0.9-0.9-0.91.21.20.7-0.6-1.10.5-1.1-0.7-1.10.7
Bone: final moment0.30.61.0-0.9-0.5-0.5-0.51.01.00.4-0.2-1.00.2-1.0-0.7-1.00.8
Food consumed during 24 hour testing period0.70.81.7-0.3-1.1-1.1-1.1-0.4-0.41.2-1.30.31.20.81.00.9-0.9
Glucose0.30.51.1-0.6-0.8-0.9-0.90.10.11.1-1.0-0.21.10.30.50.3-0.5
Heart weight1.21.83.5-1.5-0.7-0.6-0.61.81.80.2-0.1-1.8-0.2-1.9-1.6-1.81.6
Delay discount hyperbolic model param0.70.82.00.3-0.1-0.2-0.2-0.9-0.90.8-0.60.91.01.01.41.1-1.4
Intermittent access intake day 1-15 change1.91.93.71.60.60.80.8-1.8-1.7-0.30.31.90.11.91.61.9-1.7
Intermittent access intake escalation2.32.34.21.80.70.90.9-1.9-1.8-0.40.42.00.12.01.82.0-1.9
Intermittent access intake escalation 20.70.71.50.70.00.10.1-1.0-0.90.2-0.21.10.51.11.11.2-1.2
Intermitt. access day 1 inactive lever presses0.60.71.51.20.80.80.8-0.8-0.9-1.00.90.9-0.60.60.60.7-0.7
Intermitt. access day 15 inactive lever presses0.60.61.4-0.20.10.20.20.90.9-0.80.8-0.8-0.8-1.2-1.0-1.10.9
Intermitt. access escalation Index1.81.62.6-1.5-1.5-1.4-1.41.61.60.7-0.8-1.60.5-1.4-0.8-1.10.9
Intermittent access day 1 total infusions0.81.01.71.11.01.11.1-1.3-1.3-0.50.61.2-0.21.00.90.9-0.9
Intermittent access day 15 total infusions2.42.64.32.01.41.61.6-2.1-2.0-0.90.92.1-0.41.91.51.7-1.6
Intermittent access terminal intake (last 3 days)1.21.32.31.41.41.51.5-1.3-1.2-0.91.01.3-0.71.00.60.7-0.7
Intermittent access total infusions2.52.85.01.71.01.21.2-2.2-2.2-0.10.32.20.32.22.02.0-2.1
Intermittent access day 1 locomotion1.51.62.81.71.51.61.6-1.3-1.3-1.31.41.2-0.90.80.70.8-0.8
Intermittent access day 15 total locomotion0.70.81.51.21.11.21.2-0.8-0.7-1.11.20.8-0.80.40.30.4-0.4
Intermittent access total locomotion0.50.51.10.70.30.40.4-1.0-0.90.10.00.90.30.91.00.9-1.0
Intermittent access standard deviation1.51.63.11.50.81.01.0-1.7-1.6-0.60.51.8-0.21.51.41.5-1.4
Left kidney weight1.54.27.1-2.6-2.7-2.7-2.72.12.02.3-2.3-2.12.0-1.4-0.5-1.10.6
Right kidney weight1.44.07.3-2.7-2.2-2.2-2.22.22.22.1-1.9-2.31.7-1.7-0.9-1.61.1
Cocaine induced anxiety0.30.30.70.30.70.70.7-0.2-0.1-0.70.8-0.0-0.8-0.2-0.5-0.40.5
Post-drug Anxiety1.01.12.41.31.41.51.5-0.7-0.7-1.41.40.7-1.20.3-0.10.2-0.0
Baseline Anxiety0.20.20.40.60.40.50.5-0.3-0.4-0.30.40.5-0.10.40.30.5-0.5
Tail length0.41.42.70.4-0.2-0.1-0.1-1.3-1.41.1-0.91.01.31.71.61.5-1.6
Length with tail0.51.83.7-1.9-1.6-1.6-1.61.31.31.6-1.5-1.51.2-1.0-0.6-1.00.7
Length without tail2.96.311.1-3.1-2.0-2.0-2.03.23.31.0-1.1-3.10.3-3.1-2.6-3.02.7
Times rat made contact with spout0.20.20.40.60.40.40.4-0.6-0.6-0.40.20.6-0.30.60.30.6-0.4
Lifetime Intake2.22.54.61.71.21.21.2-2.1-2.1-0.20.42.10.22.01.91.8-1.9
Liver weight, left1.01.63.8-0.5-1.3-1.4-1.4-0.4-0.41.7-1.60.11.90.81.61.1-1.5
Liver weight, right1.11.83.9-1.3-1.9-1.8-1.80.30.42.0-1.9-0.62.00.10.90.3-0.7
Locomotor activity2.94.68.4-2.9-2.8-2.8-2.81.91.92.6-2.7-1.92.1-1.2-0.5-1.00.7
Locomotor testing distance1.62.75.1-2.1-2.3-2.2-2.21.41.42.1-2.1-1.31.8-0.8-0.1-0.50.2
Locomotor testing rearing1.01.52.5-1.6-1.6-1.5-1.51.21.21.5-1.4-1.11.3-0.8-0.2-0.70.3
Locomotion in novel chamber0.60.81.61.01.31.21.2-0.8-0.8-1.00.90.8-0.90.6-0.10.3-0.1
Locomotion in novel chamber post-restriction0.20.30.6-0.00.30.50.50.50.5-0.60.6-0.6-0.5-0.8-0.5-0.70.5
Fecal boli incidents, locomotor time 10.30.30.9-0.20.30.30.30.40.3-0.50.4-0.5-0.7-0.5-0.9-0.70.8
Change in fecal boli incidents, locomotor task0.70.71.3-0.2-1.0-1.0-1.0-0.3-0.31.0-1.10.41.10.71.00.9-0.9
Time >=10cm from walls, locomotor time 10.60.61.4-0.8-0.4-0.4-0.40.90.90.0-0.1-0.8-0.3-0.9-1.2-0.91.2
Bouts of movement, locomotor time 10.10.20.3-0.4-0.5-0.5-0.50.20.20.6-0.5-0.30.5-0.10.1-0.00.0
Total resting periods, locomotor time 10.10.10.2-0.2-0.4-0.4-0.4-0.10.00.5-0.4-0.10.40.10.30.2-0.2
Rest time, locomotor task time 10.10.10.30.40.20.20.2-0.6-0.3-0.10.20.3-0.00.30.40.3-0.3
Distance moved, locomotor task time 10.10.10.20.40.30.30.3-0.2-0.4-0.20.10.4-0.00.40.30.4-0.4
Vertical activity count, locomotor time 10.20.20.4-0.00.30.30.30.40.2-0.50.3-0.4-0.6-0.3-0.6-0.40.6
Time >=10cm from walls, locomotor time 20.10.10.3-0.2-0.1-0.2-0.20.30.3-0.30.0-0.3-0.4-0.3-0.5-0.30.6
Bouts of movement, locomotor time 20.50.61.3-0.7-1.1-1.1-1.10.30.31.1-1.1-0.31.0-0.00.30.2-0.2
Total resting periods, locomotor time 20.70.71.8-0.7-1.2-1.2-1.20.10.21.3-1.2-0.11.30.20.60.4-0.5
Rest time, locomotor task time 20.20.20.50.70.40.40.4-0.6-0.5-0.20.40.6-0.00.50.50.5-0.6
Distance moved, locomotor task time 20.10.10.30.1-0.1-0.1-0.1-0.3-0.30.2-0.30.30.30.40.60.5-0.5
Vertical activity count, locomotor time 20.70.81.21.11.01.01.0-1.1-1.1-0.70.51.1-0.51.00.51.0-0.6
Light reinforcement 12.95.39.0-3.0-2.8-2.7-2.72.62.71.7-1.9-2.61.3-2.3-1.4-2.01.6
Light reinforcement 20.20.20.40.50.40.50.5-0.6-0.5-0.40.40.6-0.40.40.20.3-0.2
Bone: marrow area1.22.65.2-2.0-2.3-2.3-2.31.21.22.0-2.1-1.11.8-0.70.1-0.40.1
Bone: maximum diameter1.12.04.1-1.8-2.0-2.0-2.01.01.01.7-1.9-1.01.4-0.6-0.1-0.40.3
Bone: maximum force0.81.32.2-1.5-1.1-1.1-1.11.51.50.8-0.6-1.40.5-1.4-0.9-1.30.9
Bone: maximum moment0.50.81.5-1.1-0.7-0.7-0.71.21.20.4-0.3-1.20.2-1.2-0.9-1.20.9
Mean time between licks in bursts0.20.20.4-0.00.30.30.30.50.5-0.60.6-0.2-0.6-0.7-0.7-0.60.6
Mean num. licks in bursts0.60.71.2-1.1-1.1-1.1-1.10.80.80.5-0.8-0.90.3-0.7-0.6-0.50.7
Cd content in liver0.50.61.3-0.40.10.10.10.80.9-0.40.5-1.1-0.5-1.1-0.9-1.11.0
Co content in liver1.51.83.9-0.80.10.10.11.41.5-0.80.7-1.7-1.2-1.8-1.9-1.82.0
Cu content in liver1.01.22.3-1.2-0.6-0.6-0.61.41.40.1-0.1-1.5-0.2-1.4-1.3-1.41.4
Fe content in liver1.62.03.51.50.80.80.8-1.9-1.9-0.10.21.80.31.91.81.8-1.8
K content in liver1.31.22.2-1.5-1.4-1.4-1.41.21.21.1-1.1-1.20.8-0.9-0.6-0.80.7
Mg content in liver2.82.95.0-2.2-2.0-2.0-2.01.91.91.4-1.6-1.91.0-1.5-1.0-1.31.2
Mn content in liver0.30.30.8-0.5-0.1-0.1-0.10.60.7-0.20.1-0.7-0.4-0.7-0.8-0.70.9
Na content in liver1.01.12.7-1.2-1.5-1.5-1.50.50.41.4-1.6-0.41.20.00.20.2-0.1
Rb content in liver1.21.53.8-0.9-1.5-1.5-1.50.00.11.9-1.7-0.11.90.41.20.6-1.0
Se content in liver0.60.81.21.10.80.80.8-1.1-1.1-0.30.41.10.01.01.00.9-1.0
Sr content in liver0.30.20.6-0.20.10.10.10.50.5-0.40.3-0.5-0.6-0.6-0.8-0.70.8
Zn content in liver1.71.94.3-0.30.70.70.71.31.3-1.41.3-1.3-1.7-1.7-2.1-1.82.0
Bone: minimum diameter0.40.71.5-0.50.10.10.11.01.0-0.50.5-0.9-0.7-1.2-1.2-1.21.2
Time in familiar zone, hab. session 10.60.51.5-0.5-0.1-0.1-0.10.80.8-0.40.2-0.8-0.7-0.9-1.2-0.91.2
Time in novel zone, hab. session 10.50.50.90.70.40.40.4-0.9-0.9-0.00.11.00.20.90.90.9-0.9
Total zone transitions, hab. session 10.81.22.21.20.50.50.5-1.5-1.4-0.10.11.40.21.51.41.5-1.4
Total locomotion distance, hab. session 10.30.51.00.60.20.20.2-0.9-0.90.2-0.10.80.40.91.00.9-1.0
Locomotion velocity, hab. session 10.30.41.00.4-0.0-0.1-0.1-0.7-0.70.4-0.40.60.60.81.00.9-1.0
Time in familiar zone, hab. session 20.20.20.30.30.00.00.0-0.5-0.50.1-0.10.50.20.50.60.5-0.6
Time in novel zone, hab. session 20.10.10.20.20.30.30.3-0.00.0-0.40.30.0-0.4-0.0-0.2-0.10.2
Total zone transitions, hab. session 20.50.71.2-1.0-0.5-0.5-0.51.01.00.2-0.2-1.1-0.1-1.1-1.1-1.11.1
Total locomotion distance, hab. session 21.21.52.7-1.5-0.8-0.9-0.91.61.60.4-0.4-1.60.1-1.6-1.3-1.61.4
Locomotion velocity, hab. session 20.91.32.4-1.3-0.5-0.6-0.61.51.40.1-0.1-1.5-0.2-1.6-1.3-1.61.4
Novel to familiar place preference ratio1.11.12.0-1.3-0.9-1.0-1.01.31.40.5-0.6-1.40.2-1.2-1.0-1.11.1
Novelty place preference1.21.22.1-1.3-0.9-1.0-1.01.31.40.4-0.6-1.40.1-1.2-1.1-1.11.2
Time in novel zone, NPP test1.11.11.8-1.4-1.1-1.1-1.11.31.30.6-0.8-1.30.3-1.1-0.9-1.01.0
Total zone transitions, NPP test0.10.20.3-0.6-0.5-0.5-0.50.50.40.3-0.4-0.40.1-0.3-0.4-0.30.4
Total locomotion distance, NPP test0.20.30.7-0.6-0.8-0.8-0.80.30.20.8-0.8-0.20.8-0.00.20.1-0.2
Locomotion velocity, NPP test0.10.10.3-0.2-0.4-0.5-0.50.0-0.10.6-0.60.10.60.20.30.3-0.3
Intraocular pressure0.00.00.1-0.2-0.3-0.1-0.10.30.20.2-0.2-0.20.2-0.1-0.2-0.10.1
Delta distance traveled before/after self-admin1.21.32.9-0.9-1.5-1.5-1.50.20.11.7-1.7-0.01.70.50.90.6-0.9
Delta ambulatory time before/after self-admin0.70.71.9-0.5-0.9-1.0-1.00.0-0.01.3-1.20.11.40.50.80.6-0.9
Parametrial fat weight1.12.14.41.00.30.30.3-1.7-1.80.8-0.61.61.12.12.02.0-2.0
Pavlov. Cond. lever latency0.60.81.50.90.50.40.4-1.2-1.20.10.01.10.41.21.21.2-1.2
Pavlov. Cond. magazine entry latency5.87.517.8-1.01.01.11.12.72.7-2.32.2-2.5-3.0-3.4-4.2-3.74.0
Pavlov. Cond. change in total contacts2.22.45.4-1.00.10.20.21.91.8-0.90.9-1.7-1.2-2.1-2.3-2.22.2
Pavlov. Cond. index score2.22.86.8-0.40.80.90.91.61.5-1.61.5-1.4-2.0-2.0-2.6-2.22.4
Pavlov. Cond. latency score1.62.15.2-0.60.40.50.51.51.5-1.21.1-1.3-1.6-1.8-2.3-1.92.1
Pavlov. Cond. lever contacts1.01.12.8-0.7-0.00.10.11.31.2-0.60.5-1.1-1.0-1.4-1.7-1.51.6
Pavlov. Cond. magazine entry number4.25.312.00.4-1.3-1.5-1.5-2.1-2.02.3-2.31.82.82.63.52.9-3.2
Pavlov. Cond. intertrial magazine entries1.31.63.70.6-0.3-0.3-0.3-1.3-1.31.1-0.91.21.31.61.91.7-1.8
Pavlov. Cond. lever-magazine prob. diff.2.42.97.2-0.60.60.70.71.71.7-1.51.4-1.6-1.9-2.1-2.7-2.32.5
Pavlov. Cond. response bias3.94.711.1-0.80.80.90.92.22.2-1.81.7-2.1-2.4-2.7-3.3-3.03.2
Pavlov. Cond. lever latency0.60.82.0-0.2-0.8-0.8-0.8-0.4-0.41.2-1.10.41.40.71.20.9-1.2
Pavlov. Cond. magazine entry latency2.02.34.31.92.12.12.1-1.3-1.3-1.91.91.2-1.70.8-0.00.5-0.1
Pavlov. Cond. change in total contacts0.40.61.60.50.80.90.9-0.0-0.0-1.21.00.0-1.3-0.3-0.8-0.40.8
Pavlov. Cond. index score0.60.71.80.71.11.11.1-0.2-0.2-1.31.20.2-1.3-0.2-0.7-0.30.6
Pavlov. Cond. latency score0.40.51.20.60.90.90.9-0.2-0.2-1.00.90.2-1.1-0.1-0.5-0.20.5
Pavlov. Cond. lever contacts0.40.61.30.00.60.60.60.50.5-0.90.8-0.5-1.1-0.8-1.2-0.91.1
Pavlov. Cond. magazine entry number1.82.24.1-1.8-2.0-2.0-2.01.31.31.8-1.8-1.21.6-0.8-0.1-0.60.2
Pavlov. Cond. intertrial magazine entries0.50.71.6-0.5-1.0-1.0-1.0-0.0-0.01.2-1.10.21.30.30.90.5-0.8
Pavlov. Cond. lever-magazine prob. diff.0.70.92.00.81.21.31.3-0.2-0.2-1.41.30.2-1.4-0.2-0.7-0.40.7
Pavlov. Cond. response bias1.21.63.70.51.41.41.40.30.3-1.71.7-0.4-1.9-0.9-1.5-1.11.5
Time in closed arm before self-admin0.70.82.0-0.00.80.90.90.60.6-1.00.9-0.3-1.2-0.7-1.4-1.01.3
Time in closed arm after self-admin0.10.10.2-0.20.00.10.10.30.4-0.10.1-0.2-0.2-0.3-0.4-0.40.4
Time in open arm before self-admin1.01.02.4-0.9-1.6-1.5-1.50.40.51.3-1.3-0.61.4-0.20.80.1-0.6
Time in open arm after self-admin0.91.02.40.90.10.10.1-1.2-1.40.3-0.21.10.61.31.51.4-1.5
Bone: periosteal estimation0.71.53.0-1.5-1.7-1.7-1.71.01.01.5-1.6-0.91.3-0.6-0.0-0.40.2
Bone: periosteal perimeter1.01.73.4-1.7-1.9-1.8-1.81.11.11.5-1.6-1.11.3-0.7-0.2-0.50.4
Bone: post-yield work0.10.10.2-0.4-0.3-0.4-0.40.30.30.5-0.3-0.40.5-0.20.1-0.2-0.1
Progressive ratio test 1 active lever presses0.90.91.90.60.30.20.2-1.3-1.30.6-0.31.10.71.31.41.2-1.4
Progressive ratio test 1 breakpoint0.80.81.70.90.60.60.6-1.3-1.30.10.11.10.31.21.21.1-1.2
Progressive ratio test 1 inactive lever presses3.53.86.92.21.21.21.2-2.6-2.6-0.30.52.50.32.42.42.5-2.5
Progressive ratio test 2 active lever presses0.20.20.70.1-0.10.00.0-0.4-0.40.5-0.30.40.60.50.80.5-0.8
Progressive ratio test 2 breakpoint0.40.41.10.0-0.4-0.2-0.2-0.5-0.50.8-0.60.51.00.61.00.6-1.0
Progressive ratio test 2 inactive lever presses0.80.91.71.21.21.31.3-0.9-0.9-0.91.10.9-0.60.60.50.5-0.6
Incentive Sensitization - Responses0.60.61.3-0.9-0.8-0.4-0.41.11.10.3-0.3-0.90.1-1.0-0.8-0.90.7
Incentive Sensitization - Breakpoint0.50.51.1-0.7-0.6-0.3-0.31.01.10.1-0.1-0.9-0.0-1.0-0.8-0.90.7
Sum of active levers in priming session hrs 5-60.20.20.50.2-0.00.00.0-0.5-0.60.5-0.20.50.60.60.70.5-0.7
Progressive ratio2.02.35.2-0.30.70.80.81.21.2-1.81.4-1.3-2.1-1.7-2.3-1.82.2
Food seeking constrained by brief footshock1.01.22.5-0.4-1.2-1.3-1.3-0.4-0.41.3-1.60.51.51.01.31.2-1.2
Seeking ratio, punishment vs. effort3.74.510.9-0.9-2.2-2.3-2.3-0.6-0.53.1-2.90.73.31.52.51.8-2.4
Retroperitoneal fat weight0.00.20.3-0.1-0.4-0.6-0.6-0.1-0.10.3-0.50.10.40.30.40.5-0.4
Reaction time number correct1.11.53.0-1.5-1.7-1.6-1.61.01.01.7-1.6-0.91.6-0.50.1-0.40.0
Reaction time mean minus median1.01.32.61.20.80.70.7-1.6-1.6-0.20.21.40.01.61.31.5-1.3
Reaction time mean minus median AUC2.33.05.81.91.21.21.2-2.4-2.4-0.30.42.20.12.32.02.2-2.0
Reaction time num false alarms0.71.01.61.20.90.80.8-1.2-1.2-0.20.41.20.11.21.11.1-1.2
Reaction time num false alarms AUC1.01.43.01.00.30.20.2-1.4-1.50.4-0.21.40.71.61.71.6-1.7
Reaction time trials correct on left1.11.53.0-1.5-1.7-1.6-1.61.01.01.7-1.6-0.91.6-0.50.1-0.40.0
Reaction time trials on left1.11.63.3-1.5-1.7-1.6-1.61.00.91.8-1.6-0.91.7-0.50.2-0.4-0.1
Reaction time mean2.43.45.42.32.32.22.2-2.2-2.2-1.51.62.0-1.11.81.11.4-1.1
Reaction time mean AUC2.33.15.22.22.11.91.9-2.3-2.2-1.21.32.0-0.91.91.21.5-1.2
Median of all reaction times2.63.66.42.42.52.42.4-2.1-2.0-1.92.01.9-1.61.50.71.1-0.8
Reaction time omissions0.30.51.1-0.2-0.5-0.6-0.6-0.4-0.40.9-0.80.21.00.61.00.7-0.9
Reaction time false alarm rate1.41.93.21.81.31.21.2-1.8-1.8-0.80.81.7-0.41.61.31.6-1.4
Reaction time premature initiation rate0.71.02.0-1.2-1.4-1.3-1.30.80.81.4-1.2-0.71.3-0.40.1-0.3-0.1
Reaction time premature initiations1.52.14.2-1.7-2.0-1.8-1.81.21.22.1-1.8-1.01.9-0.60.2-0.4-0.1
Std. dev. reaction times1.82.54.51.91.51.41.4-2.1-2.1-0.70.81.9-0.41.91.41.7-1.5
Reaction time trials completed1.11.63.3-1.5-1.7-1.6-1.61.00.91.8-1.6-0.91.7-0.50.2-0.4-0.1
Reaction time trials AUC0.91.42.7-1.4-1.6-1.5-1.51.00.91.6-1.5-0.91.5-0.50.1-0.40.0
Run reversals in cocaine runway, females0.20.20.70.1-0.5-0.2-0.2-0.5-0.50.4-0.40.30.50.40.80.6-0.8
Run reversals in cocaine runway, males0.30.30.50.0-0.4-0.4-0.4-0.3-0.30.6-0.60.40.60.60.50.7-0.6
Latency to leave start box in cocaine runway1.11.22.9-1.3-1.6-1.7-1.70.80.81.1-1.3-0.90.9-0.6-0.1-0.30.3
Latency to leave start box in cocaine runway, F0.30.30.9-0.3-0.9-1.0-1.00.10.10.6-0.8-0.10.70.10.50.4-0.4
Latency to leave start box in cocaine runway, M2.01.93.4-1.8-1.7-1.7-1.71.41.41.2-1.3-1.50.8-1.2-0.8-1.10.9
Std. dev. time between licks in bursts1.92.24.3-1.7-1.0-1.0-1.02.12.10.3-0.3-1.70.1-2.1-1.6-2.01.6
Total sessions with >9 infusions1.82.04.01.20.60.60.6-1.9-1.90.5-0.11.70.91.82.01.8-2.0
Short access day 1 total inactive lever presses1.92.25.31.1-0.1-0.1-0.1-1.7-1.70.7-0.61.71.21.92.32.0-2.3
Short access day 10 total inactive lever presses1.21.32.51.50.50.60.6-1.5-1.4-0.50.51.50.01.31.61.5-1.6
Short access day 1 total infusions1.01.12.21.10.60.60.6-1.5-1.40.00.21.30.41.31.51.3-1.4
Short access day 10 total infusions1.61.73.31.51.11.11.1-1.8-1.8-0.30.41.8-0.01.71.41.5-1.4
Short access total infusions2.73.05.51.91.31.31.3-2.4-2.3-0.20.62.30.32.22.12.0-2.1
Short access day 1 locomotion0.20.20.60.3-0.00.10.1-0.6-0.50.2-0.10.50.40.50.80.6-0.7
Short access day 10 total locomotion0.50.61.60.3-0.3-0.3-0.3-0.8-0.80.7-0.60.70.90.91.21.0-1.2
Short access total locomotion1.31.42.51.41.01.01.0-1.6-1.6-0.40.61.5-0.11.31.31.3-1.3
One hour access (0.3 mA shock)0.00.00.1-0.00.00.10.1-0.3-0.20.1-0.10.20.10.20.20.1-0.2
Compulsive drug intake0.30.30.6-0.6-0.7-0.7-0.70.30.30.7-0.8-0.20.6-0.00.10.0-0.1
One hour access (shock baseline)0.40.40.70.80.70.80.8-0.8-0.7-0.70.70.6-0.50.40.40.4-0.4
Social response proportion0.91.02.2-0.6-0.2-0.1-0.11.31.3-0.70.5-1.4-0.7-1.5-1.2-1.41.2
Social responses0.10.10.2-0.3-0.3-0.2-0.20.30.30.3-0.1-0.40.3-0.40.0-0.30.0
Social time0.50.71.60.5-0.2-0.2-0.2-0.9-0.90.5-0.50.70.81.01.31.2-1.2
Soleus weight9.327.349.5-6.8-7.0-7.0-7.04.74.76.0-6.3-4.75.1-3.2-1.0-2.51.5
Bone: stiffness0.81.33.7-0.7-1.3-1.3-1.3-0.1-0.11.8-1.50.11.90.61.30.7-1.2
Tibialis anterior weight6.923.745.6-6.1-6.7-6.8-6.83.93.86.1-6.3-3.85.4-2.3-0.1-1.60.5
Time to tail flick, vehicle, before self-admin0.10.10.4-0.2-0.2-0.3-0.30.40.2-0.1-0.1-0.3-0.3-0.3-0.6-0.20.5
Time to tail flick, vehicle, after self-admin0.00.00.1-0.0-0.3-0.3-0.30.10.1-0.20.1-0.3-0.1-0.30.1-0.10.0
Time to tail flick, test, before self-admin1.91.94.00.11.01.01.01.11.0-1.61.5-0.9-1.9-1.4-2.0-1.51.8
Time to tail flick, test, after self-admin2.32.34.21.91.31.51.5-2.0-2.0-0.90.91.9-0.51.71.51.6-1.5
Delta time to tail flick, vehicle, before/after SA0.10.10.20.40.30.40.4-0.3-0.2-0.30.50.2-0.10.00.40.1-0.3
Delta time to tail flick, test, before/after SA2.52.25.01.0-0.00.20.2-1.9-2.00.8-0.61.71.21.92.22.0-2.1
Tibia length0.20.71.3-0.20.30.40.40.70.7-0.80.8-1.0-0.9-1.1-1.1-1.11.2
Ambulatory time before self-admin0.10.10.30.40.50.50.5-0.3-0.2-0.10.40.30.10.30.40.2-0.5
Ambulatory time after self-admin1.01.13.1-0.3-0.8-0.8-0.8-0.4-0.41.6-1.20.51.80.91.40.9-1.4
Bone: tissue strength1.00.91.81.21.31.31.3-0.8-0.8-1.11.20.9-0.90.60.20.4-0.3
Total heroin consumption1.01.22.6-1.0-1.6-1.5-1.50.50.41.6-1.6-0.41.60.10.50.3-0.5
Bone: trabecular number0.60.92.01.01.21.21.2-0.5-0.4-1.41.30.4-1.40.1-0.5-0.10.4
Bone: trabecular spacing0.10.10.30.30.10.10.1-0.4-0.40.2-0.10.30.30.50.50.5-0.5
Bone: trabecular thickness0.10.10.20.50.30.40.4-0.4-0.4-0.40.30.3-0.30.30.20.3-0.1
Bone: trabecular tissue density3.24.59.0-2.6-3.0-3.0-3.01.61.62.7-2.9-1.42.4-0.80.2-0.4-0.0
Water consumed over 24 hours0.30.30.60.70.70.70.7-0.5-0.5-0.80.60.5-0.70.4-0.00.3-0.0
Number of responses in last shaping day0.20.20.50.60.30.40.4-0.5-0.50.00.30.40.30.40.70.4-0.7