Hub : Genes

Cgnl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL isoform ratio NM_001389277.1 0.02 0.02 1.8e-03 0.03 0.02 0.01 0.02 4.2e-04 5.1e-03 1.7e-02 1.3e-03
2 Liver gene expression Cgnl1 0.03 0.03 2.4e-03 0 0.01 0 0 3.2e-01 3.8e-02 3.5e-01 1.3e-01
3 pVTA isoform ratio NM_001389277.1 0.03 0.03 9.8e-03 0.02 0.01 0 0.01 8.7e-03 4.2e-02 1.5e-01 3.0e-02
4 PL isoform ratio XM_039081511.2 0.02 0.02 5.6e-03 0.01 0.01 0 0.01 2.1e-02 9.5e-03 1.3e-01 4.5e-02
5 pVTA gene expression Cgnl1 0.15 0.09 3.4e-09 0.11 0.12 0.1 0.1 4.7e-09 1.7e-09 4.1e-08 1.0e-08
6 Adipose gene expression Cgnl1 0.52 0.17 0.0e+00 0.34 0.37 0.37 0.38 1.4e-39 2.1e-43 3.2e-43 7.6e-44
7 BLA gene expression Cgnl1 0.11 0.07 1.6e-04 0.04 0.04 0.07 0.05 2.0e-03 2.7e-03 8.9e-05 1.5e-03
8 Adipose mRNA stability Cgnl1 0.1 0.07 8.9e-09 0.04 0.06 0.06 0.06 2.3e-05 2.4e-07 8.7e-07 4.7e-07
9 Brain gene expression Cgnl1 0.29 0.13 0.0e+00 0.2 0.2 0.2 0.21 1.5e-18 1.7e-18 6.0e-18 2.4e-19
10 IC gene expression Cgnl1 0.52 0.16 3.4e-12 0.3 0.3 0.28 0.3 3.1e-13 2.5e-13 2.0e-12 4.6e-13
11 NAcc gene expression Cgnl1 0.23 0.1 0.0e+00 0.18 0.19 0.19 0.19 1.6e-26 3.9e-28 5.7e-28 7.1e-28
12 PL gene expression Cgnl1 0.34 0.15 0.0e+00 0.18 0.2 0.2 0.2 2.7e-19 4.3e-21 1.9e-21 2.5e-21
13 IL gene expression Cgnl1 0.38 0.19 9.9e-04 0.04 0.09 0.07 0.07 4.0e-02 3.5e-03 1.0e-02 9.6e-03
14 OFC gene expression Cgnl1 0.59 0.18 9.3e-07 0.13 0.24 0.23 0.24 4.7e-04 2.6e-06 3.3e-06 2.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.20.40.80.90.20.70.80.0-0.9-0.0-0.9-0.2-0.4-0.40.5-0.6-0.7
Area under the delay curve0.40.71.60.1-0.50.00.4-0.7-0.60.7-0.7-0.9-1.1-1.11.1-1.2-1.3
BMI with tail4.615.926.0-5.1-5.0-4.5-4.2-4.73.94.83.5-4.2-3.8-3.32.9-2.2-1.9
BMI without tail0.84.28.7-3.0-2.5-2.5-2.7-2.22.72.22.5-1.7-1.3-1.11.1-0.4-0.2
Body weight3.615.825.9-4.5-5.1-4.0-3.5-5.03.34.82.8-4.5-4.0-3.93.6-3.0-2.7
Weight adjusted by age1.33.79.2-2.7-2.1-2.9-2.8-1.63.01.52.7-1.0-0.8-0.40.30.30.7
Bone surface0.10.10.2-0.3-0.5-0.4-0.4-0.40.30.40.3-0.4-0.4-0.30.2-0.2-0.2
Bone volume0.10.10.30.0-0.4-0.1-0.0-0.4-0.00.4-0.1-0.4-0.5-0.50.5-0.5-0.4
Breakpoint value in progressive ratio session0.20.30.6-0.6-0.8-0.7-0.7-0.70.60.80.7-0.6-0.3-0.40.2-0.2-0.4
Number of licking bursts0.61.92.91.51.71.41.01.7-0.9-1.6-0.81.51.61.5-1.41.11.0
Context. condit. distance diff. score0.50.61.60.80.51.01.20.3-1.3-0.4-1.3-0.0-0.2-0.40.6-0.7-0.7
Locomotion velocity, session 11.31.53.7-1.5-0.3-1.4-1.70.11.70.31.90.40.71.0-1.11.41.4
Locomotion distance, session 10.70.81.60.51.00.60.31.1-0.2-1.0-0.01.11.31.2-1.11.11.0
Locomotion velocity, session 20.20.20.5-0.5-0.0-0.5-0.60.10.6-0.00.70.30.30.4-0.40.60.7
Locomotion distance, session 20.20.30.6-0.60.0-0.4-0.60.20.6-0.00.70.30.50.6-0.50.70.6
Locomotion velocity, session 32.12.44.90.01.30.1-0.41.60.6-1.40.81.92.02.1-2.12.22.1
Locomotion distance, session 31.71.93.21.51.81.61.31.7-1.0-1.7-1.11.51.61.4-1.11.00.8
Stereotopy head waving bouts, day 30.30.30.8-0.9-0.6-0.8-0.9-0.40.80.50.9-0.2-0.2-0.1-0.20.20.2
Stereotopy head waving duration, day 30.40.41.1-1.0-0.6-1.0-1.0-0.41.00.41.1-0.1-0.10.1-0.30.40.4
Locomotion velocity, session 71.31.52.51.31.51.41.21.4-1.0-1.6-1.01.31.21.1-0.80.70.7
Locomotion distance, session 71.82.33.61.51.91.51.11.9-0.9-1.8-0.81.81.71.6-1.41.31.2
Stereotopy head waving bouts, day 70.60.61.6-1.3-0.6-1.1-1.2-0.41.30.51.3-0.10.00.2-0.30.50.6
Stereotopy head waving duration, day 70.70.91.9-1.2-0.2-1.0-1.20.11.30.01.40.40.60.8-0.81.11.2
Locomotion velocity, session 80.40.51.1-0.7-0.1-0.7-0.90.10.9-0.11.10.40.50.6-0.70.90.9
Locomotion distance, session 80.40.50.90.70.90.90.80.9-0.8-0.9-0.70.80.70.6-0.30.40.3
Degree of sensitization distance0.10.20.30.50.40.30.20.5-0.3-0.5-0.10.50.40.4-0.50.40.4
Degree of sensitization stereotypy0.40.41.1-1.0-0.4-0.8-1.0-0.21.00.31.00.00.10.3-0.30.60.6
Conditioned locomotion0.91.02.30.4-0.50.20.6-0.8-0.80.8-0.9-1.1-1.2-1.31.5-1.4-1.5
Cocaine response after cond. corrected1.01.64.1-1.8-1.1-1.8-2.0-0.82.00.82.0-0.4-0.00.1-0.30.60.7
Cocaine response after cond. not corrected0.60.82.2-1.2-0.8-1.3-1.5-0.61.50.51.5-0.20.10.2-0.20.50.6
Cocaine response before conditioning0.50.71.71.10.51.11.20.3-1.3-0.4-1.30.1-0.2-0.40.6-0.7-0.7
Saline control response1.01.42.80.21.10.4-0.11.40.3-1.20.41.51.51.6-1.51.61.7
Bone: connectivity density0.50.71.41.21.11.10.91.0-0.8-0.9-0.70.80.80.7-0.80.50.4
Bone: cortical apparent density0.91.42.11.41.41.31.01.4-0.9-1.4-0.81.31.31.1-0.90.80.7
Bone: cortical area0.00.10.10.40.30.30.20.3-0.3-0.3-0.20.20.30.3-0.20.20.2
Bone: cortical porosity0.60.71.60.90.81.21.30.6-1.3-0.8-1.30.50.30.10.3-0.3-0.3
Bone: cortical porosity1.01.12.91.00.61.41.60.2-1.6-0.5-1.7-0.0-0.2-0.50.9-1.0-1.1
Bone: cortical thickness0.91.52.81.71.51.71.61.3-1.6-1.3-1.41.00.90.7-0.50.30.1
Bone: cortical thickness0.50.61.00.90.90.90.70.9-0.7-1.0-0.60.90.90.7-0.50.40.4
Bone: cortical tissue density0.81.32.01.31.41.31.01.4-0.9-1.4-0.81.31.31.1-0.90.80.7
Condit. Reinf. active minus inactive responses1.51.63.50.0-0.90.20.6-1.2-0.61.1-0.9-1.5-1.5-1.71.8-1.9-1.8
Condit. Reinf. active-inactive response ratio1.41.43.20.8-0.40.81.2-0.7-1.20.5-1.5-1.1-1.2-1.41.6-1.8-1.8
Condit. Reinf. active responses0.60.81.4-0.5-1.0-0.6-0.3-1.10.21.10.1-1.2-1.0-1.11.1-1.0-1.1
Condit. Reinf. inactive responses0.60.82.1-0.8-0.3-1.1-1.30.01.30.21.50.30.60.7-1.01.11.0
Incentive salience index mean1.72.25.0-0.1-1.20.00.5-1.5-0.61.5-0.9-1.8-1.8-2.02.1-2.1-2.2
Condit. Reinf. lever presses0.91.33.20.1-0.80.10.5-1.1-0.61.1-0.7-1.4-1.4-1.51.6-1.6-1.8
Condit. Reinf. active minus inactive responses1.82.84.6-1.7-2.1-1.9-1.6-2.11.62.11.3-1.9-1.7-1.61.4-1.1-1.1
Condit. Reinf. active-inactive response ratio0.61.01.6-1.0-1.2-1.1-0.9-1.20.81.30.7-1.1-1.1-1.00.9-0.7-0.7
Condit. Reinf. active responses2.02.94.5-1.4-2.1-1.4-1.0-2.11.02.10.6-2.0-2.0-1.91.8-1.7-1.6
Condit. Reinf. inactive responses0.50.71.5-0.0-0.70.00.3-0.8-0.20.7-0.5-0.9-1.0-1.11.1-1.2-1.2
Condit. Reinf. lever presses0.30.41.21.10.40.91.00.3-1.0-0.1-1.1-0.1-0.1-0.20.3-0.5-0.7
Condit. Reinf. lever reinforcers received1.72.43.7-1.1-1.8-1.1-0.7-1.90.71.90.3-1.9-1.9-1.91.8-1.7-1.7
Conditioned reinforcement - actives0.00.00.10.10.20.1-0.10.20.1-0.10.10.20.40.3-0.30.30.2
Conditioned reinforcement - inactives0.20.61.00.40.90.50.31.0-0.3-1.0-0.11.00.90.9-0.80.80.8
Conditioned locomotion0.50.81.40.9-0.00.71.0-0.3-1.00.3-1.2-0.6-0.8-0.91.0-1.2-1.2
Patch foraging indifference point 0 sec0.20.61.2-0.6-0.0-0.7-1.00.21.0-0.21.10.50.70.8-1.01.01.0
Patch foraging indifference point AUC0.20.61.30.0-0.50.30.4-0.7-0.40.6-0.6-0.8-0.8-1.01.0-1.1-1.1
Delay disc. indifference point, 0s delay0.40.51.10.80.10.71.0-0.1-1.00.0-1.1-0.3-0.4-0.60.7-0.8-1.0
Delay disc. indifference point, 16s delay0.81.12.60.7-0.20.61.0-0.6-1.20.6-1.3-0.9-1.1-1.21.3-1.5-1.6
Delay disc. indifference point, 2s delay0.20.20.30.60.50.60.50.4-0.4-0.5-0.50.40.50.3-0.10.10.0
Delay disc. indifference point, 24s delay0.10.20.80.50.20.50.70.0-0.9-0.1-0.7-0.1-0.4-0.40.4-0.5-0.6
Delay disc. indifference point, 4s delay1.01.12.60.6-0.30.51.0-0.6-1.10.5-1.2-0.9-1.0-1.21.3-1.5-1.6
Delay disc. indifference point, 8s delay0.40.71.4-0.5-0.8-0.5-0.1-0.9-0.01.0-0.1-1.1-1.2-1.01.0-1.0-1.0
Indifference point function ln k0.20.61.5-1.0-0.4-1.0-1.2-0.21.20.21.20.10.20.4-0.50.70.8
Indifference point function log k0.20.61.5-1.0-0.4-1.0-1.2-0.21.20.21.20.10.20.4-0.50.70.8
Patch foraging total patch changes 0 sec0.20.71.5-0.7-0.1-0.8-1.10.21.1-0.21.20.50.70.8-1.01.11.1
Patch foraging total patch changes 12 sec0.10.10.10.20.40.30.30.4-0.3-0.3-0.20.30.30.3-0.30.20.1
Patch foraging total patch changes 18 sec0.00.00.1-0.20.10.0-0.10.20.2-0.00.20.20.30.3-0.30.30.2
Patch foraging total patch changes 24 sec0.10.51.1-0.30.2-0.4-0.60.40.6-0.30.80.70.90.9-1.11.00.9
Patch foraging total patch changes 6 sec0.10.10.3-0.4-0.3-0.6-0.5-0.20.50.20.6-0.10.10.1-0.10.20.2
Patch foraging time to switch 0 sec0.31.33.21.81.31.51.71.0-1.7-0.9-1.60.50.30.20.0-0.1-0.4
Patch foraging water rate 0 sec0.51.84.7-2.2-1.4-1.9-2.0-1.11.91.22.0-0.7-0.5-0.2-0.10.30.4
Patch foraging water rate 12 sec0.83.49.1-2.7-1.6-2.4-2.9-1.13.01.13.0-0.30.20.3-0.71.01.3
Patch foraging water rate 18 sec0.20.31.0-0.7-0.5-0.8-1.0-0.31.00.11.00.10.30.2-0.20.40.6
Patch foraging water rate 24 sec0.30.40.9-0.3-0.0-0.2-0.70.10.9-0.30.80.50.90.7-0.70.70.7
Patch foraging water rate 6 sec0.60.92.2-1.5-1.0-1.2-1.4-0.81.50.91.4-0.5-0.2-0.1-0.10.20.2
Seeking ratio, delayed vs. immediate footshock0.40.61.0-0.8-1.0-1.0-0.8-0.90.81.00.6-0.9-0.8-0.70.6-0.5-0.4
Distance traveled before self-admin0.10.10.40.00.4-0.1-0.10.50.1-0.30.10.40.40.5-0.40.50.6
Distance traveled after self-admin0.81.43.3-1.4-0.3-1.5-1.70.01.80.11.80.40.60.9-1.11.31.4
Extensor digitorum longus weight5.421.435.3-5.8-5.9-5.9-5.4-5.55.05.14.7-4.4-4.0-3.52.9-2.1-1.5
Bone: elastic displacement0.60.81.4-0.5-1.1-0.7-0.4-1.10.21.00.2-1.1-1.2-1.11.0-1.0-0.9
Bone: elastic work1.01.32.70.0-1.0-0.10.3-1.2-0.51.0-0.6-1.3-1.4-1.51.6-1.6-1.6
Bone: endosteal estimation1.02.45.0-2.1-1.9-2.2-2.1-1.62.01.72.0-1.3-1.0-0.80.5-0.20.0
Bone: endosteal perimeter2.04.88.0-2.4-2.8-2.6-2.3-2.72.12.61.9-2.4-2.2-1.91.7-1.3-1.0
Epididymis fat weight0.00.10.2-0.10.30.20.00.40.0-0.30.10.40.50.5-0.30.50.4
Delta time in closed arm before/after self-admin0.30.30.90.50.50.60.80.4-1.0-0.1-0.80.1-0.3-0.10.2-0.2-0.2
Delta time in open arm before/after self-admin1.21.42.50.71.30.70.31.4-0.3-1.5-0.01.61.51.5-1.41.41.3
Diff in mean of infusions in LGA sessions1.83.25.7-0.8-1.9-0.6-0.2-2.20.01.9-0.2-2.2-2.3-2.42.4-2.3-2.2
Delay discount exponential model param0.40.51.1-0.00.50.0-0.30.60.5-0.60.50.80.90.9-1.01.01.1
Extinction: sum of active levers before priming0.71.02.0-0.60.1-0.6-1.10.41.3-0.41.30.91.11.1-1.21.31.4
Active lever presses in extinction session 60.40.40.9-1.0-0.8-0.8-0.8-0.70.70.80.7-0.5-0.5-0.40.2-0.2-0.1
Bone: final force0.20.40.7-0.4-0.8-0.5-0.4-0.80.40.80.3-0.8-0.6-0.70.6-0.6-0.6
Bone: final moment0.10.20.4-0.0-0.5-0.1-0.0-0.50.00.5-0.1-0.6-0.5-0.60.6-0.6-0.6
Food consumed during 24 hour testing period0.50.92.1-1.1-0.2-1.0-1.30.11.4-0.01.40.50.60.8-0.91.11.2
Glucose0.40.72.1-1.1-0.4-0.9-1.2-0.21.40.21.30.10.50.5-0.60.80.8
Heart weight1.62.64.5-1.3-1.9-1.1-0.8-1.90.62.00.4-2.0-2.1-1.91.9-1.7-1.6
Delay discount hyperbolic model param0.40.61.3-0.20.4-0.2-0.50.60.7-0.50.70.80.90.9-1.01.11.2
Intermittent access intake day 1-15 change0.10.81.60.41.20.30.41.3-0.4-0.8-0.11.00.81.1-1.21.11.1
Intermittent access intake escalation0.10.30.80.30.80.20.30.9-0.4-0.4-0.10.60.40.7-0.80.80.7
Intermittent access intake escalation 20.00.00.1-0.30.1-0.3-0.20.10.20.10.20.1-0.10.2-0.20.30.3
Intermitt. access day 1 inactive lever presses0.11.23.31.21.31.21.61.2-1.8-1.2-1.50.70.00.3-0.10.00.1
Intermitt. access day 15 inactive lever presses0.00.20.8-0.5-0.4-0.7-0.2-0.40.10.40.2-0.4-0.9-0.50.4-0.3-0.1
Intermitt. access escalation Index0.41.12.6-1.1-1.2-0.8-0.5-1.20.31.30.3-1.2-1.6-1.31.2-1.0-0.8
Intermittent access day 1 total infusions0.72.03.41.61.71.51.11.6-1.0-1.8-0.91.81.81.4-1.21.00.9
Intermittent access day 15 total infusions0.71.62.61.61.61.51.31.5-1.3-1.5-1.11.41.31.1-0.90.70.6
Intermittent access terminal intake (last 3 days)0.61.02.21.51.21.41.21.0-1.1-1.1-1.11.01.00.6-0.40.20.1
Intermittent access total infusions1.51.73.41.21.51.20.71.5-0.5-1.6-0.41.71.81.5-1.41.21.1
Intermittent access day 1 locomotion1.52.74.42.02.12.01.91.9-1.8-2.0-1.61.81.31.2-1.00.80.7
Intermittent access day 15 total locomotion0.31.11.91.41.41.31.41.2-1.3-1.1-1.21.00.50.6-0.50.30.4
Intermittent access total locomotion0.20.30.60.40.60.40.20.6-0.1-0.6-0.10.80.60.6-0.60.60.6
Intermittent access standard deviation0.20.92.00.31.00.30.01.10.0-1.00.21.21.21.2-1.21.21.4
Left kidney weight0.54.09.1-3.0-2.3-2.9-2.7-1.92.61.92.6-1.4-1.4-0.90.6-0.10.1
Right kidney weight0.74.610.5-3.2-2.4-2.9-3.1-1.93.12.03.0-1.3-1.0-0.60.40.20.4
Cocaine induced anxiety0.10.40.90.4-0.10.60.7-0.2-0.80.2-0.8-0.5-0.6-0.70.8-0.8-1.0
Post-drug Anxiety1.41.62.61.51.61.61.51.5-1.5-1.4-1.31.21.00.9-0.70.60.3
Baseline Anxiety1.42.44.20.71.70.50.21.9-0.1-1.60.21.91.92.0-2.02.01.9
Tail length0.21.23.20.41.00.6-0.01.10.3-1.40.31.41.81.5-1.01.31.3
Length with tail0.20.82.0-1.1-1.1-1.1-1.2-1.01.40.61.1-0.5-0.2-0.40.5-0.2-0.0
Length without tail1.89.215.1-3.1-3.9-3.1-2.5-3.92.43.72.0-3.5-3.2-3.12.7-2.4-2.3
Times rat made contact with spout0.30.40.60.50.70.50.30.8-0.3-0.8-0.20.80.70.7-0.70.60.6
Lifetime Intake1.21.53.21.11.31.10.61.4-0.4-1.5-0.31.61.81.4-1.31.21.1
Liver weight, left2.13.67.7-2.8-2.2-2.6-2.5-1.92.42.12.4-1.5-1.3-0.90.6-0.2-0.1
Liver weight, right0.50.82.0-1.4-0.9-1.3-1.4-0.71.30.61.3-0.4-0.2-0.00.20.30.5
Locomotor activity3.14.98.8-2.7-2.8-3.0-2.8-2.62.82.42.6-1.9-1.5-1.41.0-0.7-0.5
Locomotor testing distance1.33.36.6-2.4-2.2-2.5-2.5-1.92.61.82.3-1.4-1.1-0.90.5-0.2-0.0
Locomotor testing rearing0.51.93.5-1.7-1.7-1.6-1.6-1.61.91.51.5-1.2-1.0-0.90.8-0.5-0.3
Locomotion in novel chamber0.20.20.60.70.40.70.60.3-0.5-0.4-0.60.30.50.1-0.2-0.1-0.2
Locomotion in novel chamber post-restriction0.20.61.30.5-0.00.50.9-0.3-1.10.2-1.1-0.5-0.9-0.80.8-1.0-1.0
Fecal boli incidents, locomotor time 10.10.20.40.40.10.50.6-0.0-0.5-0.3-0.6-0.1-0.1-0.30.5-0.5-0.4
Change in fecal boli incidents, locomotor task0.70.81.8-0.50.3-0.7-0.90.60.9-0.11.10.60.81.0-1.31.41.1
Time >=10cm from walls, locomotor time 10.30.40.8-0.1-0.7-0.2-0.1-0.80.30.5-0.1-0.7-0.7-0.90.8-0.9-0.6
Bouts of movement, locomotor time 10.10.10.4-0.6-0.4-0.3-0.4-0.30.50.40.4-0.3-0.2-0.20.2-0.1-0.1
Total resting periods, locomotor time 10.10.10.2-0.4-0.2-0.2-0.4-0.10.40.10.4-0.00.00.1-0.10.20.2
Rest time, locomotor task time 10.00.10.20.10.00.40.3-0.0-0.3-0.0-0.4-0.0-0.2-0.20.4-0.3-0.2
Distance moved, locomotor task time 10.00.10.20.30.4-0.00.20.4-0.3-0.3-0.10.40.30.4-0.50.40.3
Vertical activity count, locomotor time 10.00.10.30.3-0.00.10.4-0.2-0.50.1-0.5-0.2-0.3-0.40.4-0.5-0.5
Time >=10cm from walls, locomotor time 20.00.10.3-0.1-0.3-0.30.0-0.30.00.2-0.1-0.3-0.5-0.40.4-0.4-0.1
Bouts of movement, locomotor time 20.20.51.4-1.0-0.7-1.0-1.1-0.51.20.61.1-0.4-0.1-0.0-0.10.20.2
Total resting periods, locomotor time 20.20.61.8-1.1-0.6-1.1-1.2-0.41.30.51.2-0.20.10.2-0.30.50.5
Rest time, locomotor task time 20.10.30.50.40.70.60.40.7-0.5-0.5-0.30.50.50.6-0.50.50.2
Distance moved, locomotor task time 20.10.10.5-0.00.2-0.5-0.20.30.2-0.20.30.40.20.4-0.60.50.7
Vertical activity count, locomotor time 20.30.81.21.01.10.60.61.1-0.6-1.1-0.41.11.01.0-1.00.80.7
Light reinforcement 11.56.610.9-2.9-3.2-2.8-2.2-3.11.93.31.7-3.0-2.9-2.52.0-1.9-1.7
Light reinforcement 20.10.10.20.40.40.40.30.4-0.3-0.4-0.20.40.50.4-0.50.20.3
Bone: marrow area1.02.44.9-2.1-1.9-2.2-2.1-1.62.01.72.0-1.3-1.1-0.80.5-0.2-0.0
Bone: maximum diameter0.91.83.8-1.8-1.6-1.9-1.9-1.31.81.31.8-0.9-0.7-0.50.3-0.00.2
Bone: maximum force0.30.50.9-0.5-0.9-0.6-0.5-1.00.40.90.3-0.9-0.8-0.80.8-0.7-0.7
Bone: maximum moment0.20.30.5-0.1-0.6-0.2-0.1-0.7-0.00.6-0.1-0.7-0.7-0.70.7-0.7-0.6
Mean time between licks in bursts0.00.20.60.40.00.30.5-0.1-0.80.3-0.6-0.5-0.6-0.50.3-0.6-0.7
Mean num. licks in bursts0.20.61.1-1.1-1.0-1.0-0.8-0.90.70.80.7-0.7-0.8-0.70.6-0.4-0.3
Cd content in liver0.80.92.21.20.31.11.3-0.0-1.40.1-1.5-0.4-0.6-0.70.8-1.1-1.2
Co content in liver1.31.53.01.0-0.01.11.5-0.4-1.50.1-1.7-0.7-1.1-1.31.6-1.6-1.7
Cu content in liver0.30.41.00.1-0.40.10.3-0.6-0.30.4-0.5-0.6-0.7-0.81.0-0.9-0.8
Fe content in liver0.60.81.6-0.40.2-0.6-0.80.50.9-0.51.00.80.91.0-1.11.21.3
K content in liver1.11.11.8-1.3-1.3-1.3-1.1-1.31.20.91.0-1.0-0.9-0.80.8-0.6-0.3
Mg content in liver1.11.21.9-1.3-1.4-1.3-1.0-1.31.01.10.8-1.1-1.1-1.01.0-0.7-0.5
Mn content in liver0.10.10.20.0-0.20.10.2-0.3-0.10.1-0.2-0.3-0.4-0.40.5-0.4-0.4
Na content in liver3.33.87.8-2.8-2.3-2.8-2.7-1.92.71.82.6-1.3-1.0-0.80.4-0.10.2
Rb content in liver0.50.61.6-1.0-0.4-1.0-1.2-0.11.20.11.30.20.40.5-0.50.80.9
Se content in liver0.91.02.00.30.90.3-0.11.10.3-1.20.31.31.31.3-1.41.31.4
Sr content in liver0.10.10.10.30.10.30.3-0.0-0.30.0-0.4-0.1-0.1-0.20.1-0.3-0.3
Zn content in liver1.41.63.6-0.1-1.1-0.10.4-1.4-0.51.0-0.7-1.4-1.6-1.81.9-1.9-1.7
Bone: minimum diameter0.40.71.50.4-0.40.30.6-0.7-0.70.6-0.8-0.9-1.0-1.11.1-1.2-1.2
Time in familiar zone, hab. session 10.40.40.8-0.3-0.6-0.10.1-0.7-0.20.6-0.3-0.8-0.8-0.80.9-0.9-0.9
Time in novel zone, hab. session 10.40.50.90.70.80.40.20.8-0.2-0.7-0.00.80.90.9-1.00.80.7
Total zone transitions, hab. session 10.91.22.10.51.20.50.21.4-0.2-1.20.11.51.31.5-1.41.41.4
Total locomotion distance, hab. session 10.40.50.90.20.70.2-0.00.80.2-0.80.20.90.91.0-0.91.01.0
Locomotion velocity, hab. session 10.30.40.9-0.00.5-0.0-0.20.70.4-0.60.40.80.80.9-0.80.91.0
Time in familiar zone, hab. session 20.20.20.60.20.50.0-0.00.50.1-0.50.20.60.60.6-0.80.60.7
Time in novel zone, hab. session 20.00.00.10.20.10.30.30.0-0.4-0.0-0.3-0.0-0.1-0.10.2-0.2-0.2
Total zone transitions, hab. session 20.60.81.2-0.6-1.0-0.6-0.4-1.10.31.10.1-1.1-1.0-1.11.1-1.0-1.1
Total locomotion distance, hab. session 21.31.72.9-0.8-1.5-0.9-0.5-1.70.51.60.2-1.7-1.5-1.61.5-1.5-1.5
Locomotion velocity, hab. session 21.11.42.4-0.6-1.3-0.6-0.2-1.40.21.4-0.1-1.5-1.4-1.51.5-1.5-1.5
Novel to familiar place preference ratio1.11.42.2-1.1-1.4-1.0-0.7-1.50.61.50.5-1.5-1.4-1.31.3-1.1-1.1
Novelty place preference1.11.42.2-1.1-1.4-1.0-0.7-1.50.61.50.5-1.5-1.4-1.31.3-1.1-1.1
Time in novel zone, NPP test1.11.32.1-1.2-1.4-1.1-0.9-1.40.81.40.7-1.4-1.3-1.21.1-0.9-0.9
Total zone transitions, NPP test0.20.20.4-0.6-0.6-0.6-0.5-0.60.30.60.4-0.5-0.4-0.40.4-0.3-0.3
Total locomotion distance, NPP test0.20.30.7-0.8-0.6-0.8-0.8-0.50.80.60.8-0.3-0.1-0.1-0.10.10.1
Locomotion velocity, NPP test0.10.10.3-0.5-0.2-0.5-0.5-0.10.50.20.60.00.20.2-0.30.30.2
Intraocular pressure0.00.00.0-0.1-0.1-0.1-0.1-0.10.10.10.1-0.1-0.2-0.10.2-0.1-0.1
Delta distance traveled before/after self-admin0.91.02.7-1.5-0.9-1.4-1.6-0.61.60.61.6-0.2-0.00.1-0.40.50.6
Delta ambulatory time before/after self-admin0.30.51.4-1.1-0.6-1.0-1.2-0.41.20.31.2-0.00.10.2-0.30.50.5
Parametrial fat weight1.02.44.41.51.91.81.41.8-1.2-2.1-1.11.91.71.4-1.01.00.9
Pavlov. Cond. lever latency0.91.22.10.51.10.50.21.20.1-1.40.11.41.41.4-1.31.31.4
Pavlov. Cond. magazine entry latency4.96.314.71.3-1.20.91.9-2.0-2.21.5-2.5-2.5-2.8-3.23.3-3.7-3.8
Pavlov. Cond. change in total contacts2.52.75.90.2-1.20.00.7-1.6-0.91.5-1.1-1.9-2.1-2.22.2-2.4-2.4
Pavlov. Cond. index score2.22.86.60.9-0.70.71.3-1.2-1.61.0-1.7-1.6-1.8-2.12.1-2.4-2.6
Pavlov. Cond. latency score1.72.25.20.5-0.90.30.9-1.2-1.11.2-1.3-1.6-1.8-1.91.9-2.1-2.3
Pavlov. Cond. lever contacts1.41.73.6-0.1-1.1-0.20.3-1.3-0.51.3-0.6-1.6-1.7-1.71.7-1.8-1.9
Pavlov. Cond. magazine entry number3.84.911.3-1.50.8-1.2-2.01.52.2-1.12.52.02.22.7-2.83.23.4
Pavlov. Cond. intertrial magazine entries1.11.43.0-0.40.6-0.3-0.81.01.0-0.71.11.21.41.6-1.61.71.6
Pavlov. Cond. lever-magazine prob. diff.2.42.96.90.6-1.00.41.1-1.4-1.41.2-1.5-1.8-2.0-2.22.3-2.5-2.6
Pavlov. Cond. response bias4.15.111.90.9-1.30.61.5-1.9-1.81.5-2.1-2.3-2.6-2.93.0-3.3-3.4
Pavlov. Cond. lever latency0.40.61.4-0.80.1-0.7-0.90.30.9-0.31.00.60.60.8-0.91.11.2
Pavlov. Cond. magazine entry latency1.62.24.52.11.82.12.01.5-1.9-1.4-1.91.11.00.7-0.60.2-0.1
Pavlov. Cond. change in total contacts0.20.41.10.90.50.91.00.3-1.0-0.2-1.0-0.0-0.1-0.20.2-0.4-0.6
Pavlov. Cond. index score0.40.71.61.20.71.21.30.4-1.2-0.3-1.30.10.0-0.10.2-0.5-0.7
Pavlov. Cond. latency score0.20.40.91.00.60.91.00.4-0.9-0.3-1.00.10.1-0.10.0-0.3-0.5
Pavlov. Cond. lever contacts0.30.51.00.70.00.70.8-0.2-0.80.2-0.9-0.4-0.5-0.60.7-0.9-1.0
Pavlov. Cond. magazine entry number1.82.44.6-2.1-1.9-2.1-2.0-1.71.91.51.8-1.3-1.2-1.00.8-0.4-0.1
Pavlov. Cond. intertrial magazine entries0.30.71.8-1.1-0.7-1.2-1.3-0.51.40.41.3-0.1-0.10.1-0.40.50.7
Pavlov. Cond. lever-magazine prob. diff.0.50.71.81.30.81.31.30.5-1.3-0.4-1.30.20.1-0.10.1-0.4-0.6
Pavlov. Cond. response bias1.01.43.61.60.51.51.80.1-1.8-0.2-1.9-0.3-0.4-0.70.9-1.2-1.4
Time in closed arm before self-admin0.30.51.50.7-0.20.80.7-0.4-0.60.2-0.9-0.6-0.4-0.80.8-1.0-1.2
Time in closed arm after self-admin0.20.20.50.70.30.60.70.1-0.6-0.2-0.70.1-0.1-0.20.2-0.4-0.3
Time in open arm before self-admin0.80.91.9-1.3-1.1-1.4-0.9-1.00.71.30.8-1.0-1.2-0.80.6-0.4-0.2
Time in open arm after self-admin0.10.10.4-0.6-0.1-0.5-0.50.10.4-0.00.60.20.00.3-0.20.50.5
Bone: periosteal estimation0.41.02.2-1.3-1.2-1.5-1.5-0.91.41.01.4-0.7-0.5-0.30.20.00.2
Bone: periosteal perimeter0.71.42.9-1.5-1.4-1.7-1.6-1.31.51.31.5-1.0-0.8-0.60.5-0.20.0
Bone: post-yield work0.00.10.1-0.2-0.4-0.4-0.3-0.40.30.30.3-0.3-0.2-0.20.3-0.2-0.1
Progressive ratio test 1 active lever presses0.71.22.20.91.20.90.61.3-0.4-1.4-0.31.51.51.2-1.21.01.0
Progressive ratio test 1 breakpoint0.71.22.11.01.31.00.61.3-0.5-1.4-0.41.51.51.2-1.21.01.0
Progressive ratio test 1 inactive lever presses2.77.011.42.33.22.21.73.3-1.4-3.4-1.13.33.13.0-2.72.52.3
Progressive ratio test 2 active lever presses0.10.10.3-0.10.20.1-0.20.30.2-0.40.30.50.40.4-0.40.50.6
Progressive ratio test 2 breakpoint0.10.10.3-0.10.20.1-0.10.30.2-0.40.20.50.40.4-0.40.50.6
Progressive ratio test 2 inactive lever presses0.30.91.80.91.11.20.81.1-0.7-1.3-0.61.21.00.9-0.70.60.7
Incentive Sensitization - Responses0.20.51.2-0.6-0.8-0.3-0.2-0.90.10.80.1-0.9-1.1-0.90.9-0.8-0.8
Incentive Sensitization - Breakpoint0.20.51.1-0.5-0.7-0.2-0.1-0.8-0.00.8-0.0-0.8-1.1-0.90.9-0.8-0.7
Sum of active levers in priming session hrs 5-60.40.40.8-0.40.2-0.3-0.60.40.6-0.40.70.60.80.8-0.90.90.8
Progressive ratio0.72.24.70.9-0.30.81.4-0.8-1.80.9-1.8-1.3-1.7-1.71.7-2.0-2.2
Food seeking constrained by brief footshock0.81.12.3-0.90.2-0.9-1.20.51.00.01.40.60.81.1-1.41.51.3
Seeking ratio, punishment vs. effort1.73.89.7-2.4-0.8-2.3-2.9-0.23.00.43.10.51.01.3-1.62.02.2
Retroperitoneal fat weight0.52.14.10.41.50.90.21.6-0.0-1.70.11.92.01.9-1.61.71.7
Reaction time number correct0.31.12.5-1.4-1.3-1.3-1.5-1.11.61.11.4-0.8-0.5-0.50.4-0.2-0.1
Reaction time mean minus median0.21.22.50.61.20.50.21.30.1-1.20.11.41.61.5-1.51.41.3
Reaction time mean minus median AUC0.53.05.80.91.91.10.42.1-0.1-1.90.02.12.42.3-2.22.12.0
Reaction time num false alarms0.61.11.70.91.20.70.51.3-0.3-1.2-0.21.31.31.2-1.31.11.1
Reaction time num false alarms AUC0.71.63.10.61.20.3-0.01.40.2-1.40.41.61.61.6-1.71.61.8
Reaction time trials correct on left0.31.12.5-1.4-1.3-1.3-1.5-1.11.61.11.4-0.8-0.5-0.50.4-0.2-0.1
Reaction time trials on left0.31.22.7-1.4-1.3-1.3-1.5-1.11.71.11.4-0.8-0.5-0.40.3-0.10.0
Reaction time mean1.53.25.12.12.22.01.72.1-1.4-2.3-1.32.02.11.7-1.41.21.1
Reaction time mean AUC1.23.04.91.92.11.71.42.0-1.0-2.2-1.02.02.21.8-1.61.31.3
Median of all reaction times2.53.96.62.62.42.42.22.2-2.0-2.4-1.92.02.01.5-1.20.90.7
Reaction time omissions0.30.51.1-0.40.1-0.5-0.70.30.8-0.40.90.70.60.7-1.01.01.1
Reaction time false alarm rate1.52.13.21.41.81.00.91.8-0.8-1.8-0.51.81.61.6-1.61.41.4
Reaction time premature initiation rate0.60.91.9-1.4-1.1-1.1-1.3-0.91.11.21.2-0.8-0.6-0.40.3-0.1-0.2
Reaction time premature initiations0.51.63.3-1.8-1.5-1.5-1.7-1.31.71.51.6-1.1-0.7-0.60.4-0.2-0.2
Std. dev. reaction times0.72.54.11.41.91.30.91.9-0.6-1.9-0.61.92.01.8-1.71.51.5
Reaction time trials completed0.31.22.7-1.4-1.3-1.3-1.5-1.11.71.11.4-0.8-0.5-0.40.3-0.10.0
Reaction time trials AUC0.31.02.1-1.3-1.3-1.2-1.4-1.11.51.11.3-0.8-0.5-0.50.3-0.2-0.1
Run reversals in cocaine runway, females0.30.30.7-0.30.4-0.3-0.20.60.1-0.40.40.70.40.7-0.90.80.9
Run reversals in cocaine runway, males0.20.20.4-0.5-0.0-0.5-0.60.10.60.30.70.10.30.4-0.60.60.3
Latency to leave start box in cocaine runway0.81.12.9-1.7-1.1-1.6-1.5-0.81.50.91.4-0.6-0.8-0.30.20.20.3
Latency to leave start box in cocaine runway, F0.50.61.5-1.1-0.1-1.0-1.10.21.10.21.20.30.20.6-0.71.01.0
Latency to leave start box in cocaine runway, M3.23.05.0-2.2-2.2-2.2-1.8-2.11.81.81.6-1.6-1.7-1.51.3-1.0-0.7
Std. dev. time between licks in bursts1.42.74.7-0.9-1.8-1.0-0.5-2.00.11.90.1-2.1-2.2-2.11.8-1.9-1.9
Total sessions with >9 infusions2.63.27.21.21.81.20.42.0-0.0-2.10.02.32.72.3-2.22.01.9
Short access day 1 total inactive lever presses0.81.62.70.91.50.80.61.6-0.5-1.5-0.31.61.41.5-1.51.41.3
Short access day 10 total inactive lever presses0.10.81.60.71.20.70.81.3-1.0-1.2-0.61.10.50.8-0.80.80.9
Short access day 1 total infusions0.51.11.90.51.20.50.21.3-0.2-1.20.01.41.21.3-1.41.31.2
Short access day 10 total infusions1.62.74.51.91.91.91.41.9-1.1-2.1-1.12.02.11.6-1.41.10.9
Short access total infusions2.02.85.31.51.91.50.91.9-0.6-2.1-0.52.12.31.9-1.81.61.5
Short access day 1 locomotion0.00.00.10.10.20.20.30.2-0.3-0.1-0.20.1-0.2-0.00.0-0.0-0.0
Short access day 10 total locomotion0.31.42.40.51.30.60.21.4-0.1-1.40.01.51.41.5-1.51.51.4
Short access total locomotion0.91.32.21.01.41.10.71.4-0.5-1.4-0.51.51.41.3-1.21.11.1
One hour access (0.3 mA shock)0.20.20.5-0.5-0.6-0.5-0.7-0.50.70.30.7-0.1-0.1-0.20.10.00.1
Compulsive drug intake0.60.92.6-0.9-0.6-1.1-1.5-0.31.60.21.60.20.60.5-0.70.81.0
One hour access (shock baseline)0.10.20.60.50.30.60.70.2-0.8-0.2-0.70.1-0.2-0.20.3-0.3-0.4
Social response proportion0.81.02.3-0.2-0.6-0.10.4-0.8-0.81.0-0.7-1.1-1.5-1.31.3-1.3-1.4
Social responses0.00.00.1-0.2-0.20.0-0.0-0.2-0.00.3-0.0-0.2-0.3-0.30.2-0.3-0.3
Social time0.50.82.3-0.20.70.0-0.30.90.5-0.80.61.21.01.2-1.21.31.5
Soleus weight9.929.151.2-7.1-6.8-7.2-6.6-6.26.45.85.9-4.8-4.3-3.62.9-1.9-1.2
Bone: stiffness0.61.12.2-0.9-0.0-0.9-1.30.31.4-0.21.50.61.01.1-1.21.41.5
Tibialis anterior weight7.425.450.1-7.1-6.1-7.1-6.8-5.36.55.16.2-3.9-3.3-2.61.8-0.8-0.1
Time to tail flick, vehicle, before self-admin0.20.20.50.2-0.10.20.4-0.2-0.40.3-0.5-0.4-0.4-0.50.6-0.6-0.7
Time to tail flick, vehicle, after self-admin0.10.20.60.40.70.60.70.6-0.8-0.5-0.60.4-0.10.2-0.20.10.2
Time to tail flick, test, before self-admin1.92.24.61.50.01.41.8-0.5-1.90.2-2.0-0.9-1.1-1.41.7-1.9-2.2
Time to tail flick, test, after self-admin1.92.03.31.51.81.61.41.7-1.4-1.7-1.21.61.21.2-1.00.90.8
Delta time to tail flick, vehicle, before/after SA0.50.51.00.51.00.60.51.0-0.5-0.9-0.40.90.60.8-0.80.70.7
Delta time to tail flick, test, before/after SA1.11.33.1-0.30.7-0.2-0.61.00.7-1.00.91.41.41.5-1.61.61.7
Tibia length0.30.71.60.1-0.30.50.7-0.6-0.80.7-0.9-0.9-1.0-1.01.2-1.2-1.3
Ambulatory time before self-admin0.20.61.10.60.90.60.30.9-0.2-0.9-0.10.91.10.9-0.80.80.8
Ambulatory time after self-admin0.60.91.6-0.80.1-0.7-1.10.41.2-0.31.30.70.91.0-1.11.31.3
Bone: tissue strength0.80.81.81.31.11.11.11.0-1.1-1.0-1.00.80.70.6-0.50.30.2
Total heroin consumption0.60.71.7-1.2-0.9-1.3-1.3-0.71.00.91.2-0.6-0.5-0.2-0.00.10.0
Bone: trabecular number0.40.82.21.50.81.31.30.5-1.3-0.5-1.30.20.1-0.10.3-0.4-0.5
Bone: trabecular spacing0.10.10.3-0.30.2-0.1-0.20.30.2-0.40.30.40.50.5-0.40.50.5
Bone: trabecular thickness0.20.30.50.70.70.70.60.7-0.6-0.7-0.50.60.40.5-0.20.30.4
Bone: trabecular tissue density1.93.48.8-3.0-2.0-2.7-2.7-1.62.51.62.6-1.0-0.9-0.50.10.20.5
Water consumed over 24 hours0.10.20.40.60.60.70.60.5-0.6-0.5-0.60.40.30.3-0.20.10.0
Number of responses in last shaping day0.00.10.20.10.20.30.30.1-0.40.1-0.4-0.1-0.4-0.10.1-0.1-0.3