Hub : Genes

Rps15a

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Rps15a 0.14 0.12 9.8e-04 0.04 0.06 0.06 0.06 5.9e-03 2.0e-03 2.5e-03 1.8e-03
2 pVTA intron excision ratio chr1_181860280_181861108 0.1 0.06 7.6e-08 0.08 0.07 0.07 0.08 5.6e-07 1.4e-06 5.6e-06 5.1e-07
3 IL gene expression Rps15a 0.16 0.1 9.3e-03 -0 0 -0.01 -0 3.5e-01 2.8e-01 9.7e-01 4.0e-01
4 BLA gene expression Rps15a 0.14 0.08 8.1e-06 0.06 0.1 0.08 0.09 5.6e-04 6.7e-06 4.6e-05 1.9e-05
5 Liver intron excision ratio chr1_181860280_181861108 0.17 0.08 1.7e-13 0.09 0.08 0.08 0.08 9.8e-10 2.7e-09 4.3e-09 4.6e-09
6 pVTA intron excision ratio chr1_181860280_181861215 0.05 0.03 7.2e-05 0.04 0.04 0.04 0.04 2.0e-04 3.7e-04 3.0e-04 3.4e-04
7 PL intron excision ratio chr1_181860280_181861215 0.02 0.01 3.1e-03 0.02 0.02 0.01 0.01 6.3e-03 3.0e-03 1.0e-02 7.9e-03
8 PL intron excision ratio chr1_181860280_181861108 0.04 0.02 4.2e-05 0.03 0.04 0.04 0.04 1.2e-04 1.4e-05 6.0e-05 7.8e-05
9 Liver intron excision ratio chr1_181860280_181861215 0.19 0.08 0.0e+00 0.09 0.11 0.11 0.11 1.4e-10 3.5e-12 2.7e-12 5.8e-12
10 BLA intron excision ratio chr1_181860280_181861215 0.11 0.07 1.8e-05 0.03 0.09 0.06 0.06 1.2e-02 3.1e-05 3.7e-04 2.9e-04
11 PL gene expression Rps15a 0.04 0.03 8.8e-04 0.03 0.01 0.01 0.01 5.2e-04 9.2e-03 8.4e-03 2.1e-02
12 IC intron excision ratio chr1_181860280_181861108 0.09 0.06 4.8e-03 0 0.02 0.02 0.01 2.6e-01 4.7e-02 5.9e-02 1.5e-01
13 BLA intron excision ratio chr1_181860280_181861108 0.17 0.1 2.6e-08 0.07 0.15 0.12 0.12 1.4e-04 3.3e-08 4.9e-07 5.7e-07
14 Brain intron excision ratio chr1_181860280_181861215 0.05 0.03 1.3e-03 0.02 0.02 0.03 0.02 4.9e-03 7.1e-03 1.3e-03 3.9e-03
15 Brain intron excision ratio chr1_181860280_181861108 0.06 0.04 1.3e-04 0.03 0.03 0.03 0.02 6.2e-04 1.9e-03 9.4e-04 2.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.01.83.9-2.01.6-1.5-1.7-1.71.6-1.21.01.6-0.81.80.80.70.20.2
Area under the delay curve0.10.20.50.5-0.20.70.60.3-0.40.6-0.70.10.70.0-0.4-0.5-0.3-0.0
BMI with tail4.515.823.9-4.64.6-4.9-4.6-4.14.0-4.54.53.6-3.93.13.63.53.1-2.0
BMI without tail4.021.132.5-5.55.3-5.7-5.5-5.04.9-5.04.94.3-4.14.63.93.53.4-2.0
Body weight2.912.623.0-4.64.3-4.8-4.6-3.73.7-3.83.73.3-2.93.52.62.42.0-0.8
Weight adjusted by age0.10.20.4-0.40.1-0.5-0.5-0.40.3-0.40.5-0.5-0.6-0.10.20.50.1-0.2
Bone surface1.02.03.0-1.41.7-1.4-1.4-1.71.6-1.61.51.7-1.41.11.41.41.0-0.7
Bone volume1.63.15.0-2.12.2-1.8-1.9-2.12.1-1.81.62.1-1.51.81.51.40.9-0.8
Breakpoint value in progressive ratio session1.22.23.91.3-1.71.41.21.5-1.41.7-1.6-2.01.5-0.9-1.6-1.5-1.41.1
Number of licking bursts1.95.811.53.1-2.63.43.32.7-2.62.4-2.4-1.91.9-2.9-1.7-1.4-1.40.5
Context. condit. distance diff. score0.50.61.40.5-0.70.50.40.7-0.70.9-0.8-1.20.8-0.5-0.9-0.8-1.00.6
Locomotion velocity, session 10.10.10.30.5-0.10.60.4-0.20.10.2-0.30.50.1-0.00.10.1-0.20.0
Locomotion distance, session 10.50.71.6-1.00.9-1.0-1.2-1.11.2-0.50.40.9-0.41.30.20.3-0.40.4
Locomotion velocity, session 20.40.51.30.9-0.71.10.80.3-0.20.8-0.90.10.7-0.2-0.5-0.4-1.00.7
Locomotion distance, session 21.31.83.6-1.41.5-1.2-1.4-1.81.8-1.31.11.9-1.21.41.21.20.5-0.3
Locomotion velocity, session 30.10.20.4-0.30.4-0.4-0.4-0.50.7-0.40.40.5-0.40.40.40.40.1-0.2
Locomotion distance, session 30.60.73.00.10.30.10.2-0.30.3-0.70.80.4-1.0-0.61.01.11.2-1.7
Stereotopy head waving bouts, day 30.91.12.40.5-0.90.50.40.8-0.81.2-1.2-0.81.3-0.0-1.3-1.3-1.51.6
Stereotopy head waving duration, day 30.50.72.70.1-0.60.2-0.00.4-0.30.8-0.9-0.41.00.4-1.0-1.1-1.31.6
Locomotion velocity, session 71.41.54.7-0.30.8-0.3-0.2-1.01.1-1.31.30.5-1.7-0.31.61.71.6-2.2
Locomotion distance, session 70.30.41.10.6-0.10.60.70.1-0.0-0.40.40.2-0.7-1.10.80.90.8-0.9
Stereotopy head waving bouts, day 70.10.10.4-0.50.2-0.2-0.4-0.20.30.3-0.40.00.40.6-0.5-0.5-0.40.3
Stereotopy head waving duration, day 71.21.42.8-1.71.4-1.6-1.6-1.31.4-1.11.10.9-0.91.30.80.70.8-0.6
Locomotion velocity, session 80.10.20.50.2-0.30.50.2-0.10.10.5-0.60.10.40.3-0.4-0.3-0.70.5
Locomotion distance, session 80.10.10.9-0.30.20.0-0.3-0.50.50.1-0.30.20.10.4-0.2-0.0-0.90.5
Degree of sensitization distance0.60.73.00.0-0.30.1-0.20.2-0.20.8-0.9-0.21.10.7-1.0-1.1-1.31.7
Degree of sensitization stereotypy0.91.01.8-1.21.2-0.9-1.0-1.21.3-0.90.91.0-0.91.00.80.80.7-0.7
Conditioned locomotion0.60.83.01.1-1.01.11.21.0-1.00.5-0.4-0.90.1-1.7-0.2-0.00.1-0.4
Cocaine response after cond. corrected0.10.20.40.6-0.40.50.60.5-0.40.3-0.3-0.10.3-0.5-0.2-0.2-0.20.2
Cocaine response after cond. not corrected0.20.40.9-0.20.6-0.5-0.3-0.30.4-0.80.80.6-0.70.00.80.70.9-0.6
Cocaine response before conditioning3.34.05.8-1.72.2-1.9-1.6-1.81.7-2.42.41.8-2.30.92.22.12.4-2.0
Saline control response0.10.10.4-0.3-0.0-0.3-0.20.3-0.40.3-0.3-0.30.50.4-0.6-0.7-0.30.5
Bone: connectivity density0.81.22.0-1.41.1-1.3-1.3-1.21.1-1.21.21.0-1.01.11.00.90.9-0.3
Bone: cortical apparent density0.71.12.31.2-1.11.51.41.2-1.21.1-1.1-0.80.9-1.0-0.7-0.7-0.60.3
Bone: cortical area2.84.67.3-2.32.7-2.2-2.3-2.62.7-2.32.12.5-1.91.81.91.91.0-0.8
Bone: cortical porosity0.60.71.5-1.20.8-1.2-1.2-0.90.8-0.80.90.4-0.70.90.50.50.5-0.4
Bone: cortical porosity0.20.20.7-0.80.2-0.9-0.9-0.40.3-0.30.3-0.2-0.20.6-0.0-0.10.0-0.0
Bone: cortical thickness1.01.64.5-1.31.7-1.1-1.4-1.71.8-1.10.82.1-0.71.50.90.80.00.3
Bone: cortical thickness0.50.62.8-0.60.9-0.4-0.6-0.90.9-0.40.11.7-0.01.30.30.2-0.20.7
Bone: cortical tissue density0.71.12.21.2-1.11.51.41.2-1.21.1-1.1-0.80.9-1.0-0.7-0.7-0.60.3
Condit. Reinf. active minus inactive responses0.20.20.5-0.2-0.1-0.3-0.30.3-0.40.3-0.3-0.50.50.2-0.6-0.6-0.60.7
Condit. Reinf. active-inactive response ratio0.10.10.5-0.50.2-0.7-0.50.1-0.2-0.20.3-0.5-0.10.1-0.1-0.1-0.00.2
Condit. Reinf. active responses0.30.30.90.1-0.30.1-0.10.3-0.30.6-0.6-0.40.70.2-0.8-0.8-0.90.9
Condit. Reinf. inactive responses0.20.20.70.3-0.30.30.10.00.00.6-0.7-0.00.60.2-0.6-0.5-0.80.7
Incentive salience index mean0.10.10.3-0.20.2-0.3-0.2-0.10.0-0.40.5-0.2-0.5-0.20.30.40.3-0.4
Condit. Reinf. lever presses0.20.31.00.3-0.10.20.30.2-0.1-0.40.5-0.5-0.7-0.90.50.70.6-1.0
Condit. Reinf. active minus inactive responses0.60.92.6-1.40.8-1.5-1.6-0.90.9-0.30.30.20.01.6-0.3-0.3-0.71.0
Condit. Reinf. active-inactive response ratio0.30.41.1-0.80.2-1.0-1.0-0.10.10.1-0.1-0.40.41.0-0.6-0.7-0.60.9
Condit. Reinf. active responses0.40.61.7-1.20.7-1.2-1.3-0.90.8-0.50.50.2-0.31.20.10.1-0.40.5
Condit. Reinf. inactive responses0.71.01.8-0.71.0-0.6-0.6-1.11.1-1.11.10.9-1.30.21.31.40.8-1.0
Condit. Reinf. lever presses1.52.25.2-2.01.8-2.3-2.2-1.51.5-1.51.51.0-1.11.50.90.80.6-0.0
Condit. Reinf. lever reinforcers received0.30.41.2-0.90.4-1.0-1.1-0.50.5-0.20.2-0.20.01.0-0.2-0.2-0.60.7
Conditioned reinforcement - actives0.00.10.5-0.20.4-0.2-0.2-0.10.1-0.1-0.00.70.20.40.1-0.20.3-0.1
Conditioned reinforcement - inactives0.20.61.21.1-0.81.11.01.0-0.90.8-0.9-0.20.8-0.9-0.5-0.6-0.40.2
Conditioned locomotion0.10.20.50.7-0.40.70.60.4-0.30.3-0.3-0.10.2-0.4-0.0-0.10.2-0.2
Patch foraging indifference point 0 sec0.30.93.1-1.30.8-1.4-1.5-0.80.8-0.1-0.00.50.41.8-0.5-0.7-0.81.1
Patch foraging indifference point AUC0.30.81.6-1.10.9-0.9-0.9-1.11.0-0.90.81.3-0.61.00.70.60.6-0.0
Delay disc. indifference point, 0s delay1.11.32.7-0.41.1-0.1-0.1-1.01.1-1.11.01.6-1.20.21.51.51.4-1.6
Delay disc. indifference point, 16s delay3.75.37.82.0-2.32.21.92.3-2.32.7-2.8-2.12.7-1.0-2.6-2.6-2.41.8
Delay disc. indifference point, 2s delay4.34.86.2-2.02.5-1.8-1.8-2.42.4-2.42.32.5-2.31.62.42.32.1-1.8
Delay disc. indifference point, 24s delay2.64.15.32.3-2.22.32.22.2-2.32.3-2.2-1.82.1-1.6-1.9-1.9-1.51.1
Delay disc. indifference point, 4s delay0.10.20.8-0.10.40.40.1-0.30.30.2-0.50.90.40.6-0.1-0.2-0.1-0.2
Delay disc. indifference point, 8s delay0.10.10.70.10.50.30.3-0.20.1-0.10.00.6-0.1-0.10.30.20.5-0.8
Indifference point function ln k0.00.10.2-0.20.3-0.3-0.4-0.40.4-0.30.20.3-0.20.50.20.2-0.0-0.0
Indifference point function log k0.00.10.2-0.20.3-0.3-0.4-0.40.4-0.30.20.3-0.20.50.20.2-0.0-0.0
Patch foraging total patch changes 0 sec0.41.23.8-1.50.9-1.6-1.8-0.80.8-0.20.10.50.42.0-0.5-0.7-0.81.3
Patch foraging total patch changes 12 sec0.20.30.7-0.80.4-0.8-0.9-0.60.5-0.30.30.4-0.20.60.00.1-0.10.6
Patch foraging total patch changes 18 sec0.00.10.4-0.00.2-0.4-0.4-0.20.20.0-0.10.50.30.6-0.2-0.3-0.10.4
Patch foraging total patch changes 24 sec0.31.02.6-1.51.1-1.6-1.6-1.00.9-0.70.51.0-0.11.60.1-0.1-0.21.0
Patch foraging total patch changes 6 sec1.11.96.0-0.5-0.3-0.3-0.70.1-0.21.2-1.5-0.01.91.7-1.8-2.0-2.12.5
Patch foraging time to switch 0 sec0.93.58.72.6-2.22.52.52.2-2.01.6-1.4-2.20.8-2.9-0.9-0.6-0.5-0.4
Patch foraging water rate 0 sec0.10.51.1-1.10.7-1.0-1.0-0.70.7-0.60.50.6-0.41.00.30.20.00.3
Patch foraging water rate 12 sec0.52.15.7-2.11.7-2.3-2.2-1.31.3-1.11.01.4-0.42.40.40.00.30.7
Patch foraging water rate 18 sec0.30.61.8-1.10.4-1.1-1.2-0.50.5-0.10.10.10.21.4-0.3-0.4-0.61.1
Patch foraging water rate 24 sec0.40.51.3-1.10.8-0.6-0.7-0.90.9-0.60.41.0-0.31.20.50.40.10.2
Patch foraging water rate 6 sec0.20.31.0-0.50.3-0.3-0.4-0.10.10.1-0.30.60.51.0-0.3-0.5-0.51.0
Seeking ratio, delayed vs. immediate footshock0.00.00.1-0.10.1-0.0-0.0-0.20.3-0.10.10.1-0.10.10.20.20.2-0.2
Distance traveled before self-admin0.00.10.7-0.10.30.10.0-0.30.4-0.20.10.8-0.20.20.40.30.3-0.3
Distance traveled after self-admin1.52.64.5-0.91.6-0.9-0.8-1.61.6-1.81.72.0-1.80.62.12.02.0-1.8
Extensor digitorum longus weight5.421.729.7-3.75.0-3.6-3.4-4.84.8-5.45.34.8-5.31.95.45.45.1-4.4
Bone: elastic displacement0.81.01.90.5-1.10.70.60.8-0.81.2-1.3-0.51.40.2-1.2-1.3-1.11.3
Bone: elastic work0.30.41.1-0.70.6-0.6-0.7-0.70.8-0.50.41.0-0.30.90.40.30.2-0.0
Bone: endosteal estimation1.84.56.5-2.02.2-2.1-1.9-2.12.0-2.52.51.6-2.51.02.32.32.1-2.0
Bone: endosteal perimeter1.02.54.5-1.11.5-1.0-1.0-1.51.5-1.81.91.2-2.1-0.11.92.11.6-2.0
Epididymis fat weight0.73.37.0-2.62.1-2.6-2.6-2.12.1-1.71.61.6-1.22.31.00.90.30.2
Delta time in closed arm before/after self-admin1.01.02.90.10.3-0.00.2-0.30.5-1.01.10.2-1.4-0.81.31.51.5-1.7
Delta time in open arm before/after self-admin1.51.83.8-1.91.7-1.8-1.9-1.61.5-1.21.11.3-0.81.70.70.70.40.2
Diff in mean of infusions in LGA sessions0.61.13.1-0.2-0.50.2-0.10.4-0.31.2-1.3-0.61.50.7-1.5-1.5-1.61.8
Delay discount exponential model param0.20.30.7-0.60.3-0.8-0.7-0.40.5-0.60.70.0-0.70.10.40.50.30.1
Extinction: sum of active levers before priming0.30.51.20.8-0.90.70.80.8-0.80.6-0.5-1.10.4-0.9-0.5-0.4-0.50.3
Active lever presses in extinction session 60.10.10.2-0.20.1-0.3-0.30.10.10.1-0.0-0.50.20.3-0.3-0.3-0.20.4
Bone: final force4.57.411.1-2.93.2-2.6-2.8-3.23.3-2.92.73.1-2.62.42.62.61.6-1.2
Bone: final moment3.96.39.7-2.92.9-2.6-2.7-3.03.1-2.62.42.8-2.22.42.22.21.3-0.9
Food consumed during 24 hour testing period1.02.03.1-1.31.8-1.1-1.2-1.71.7-1.51.41.6-1.41.01.51.51.1-1.3
Glucose0.20.30.80.2-0.60.30.20.1-0.20.6-0.7-0.20.60.4-0.6-0.6-0.90.8
Heart weight0.00.10.30.00.2-0.0-0.2-0.40.50.0-0.10.40.10.4-0.0-0.0-0.40.4
Delay discount hyperbolic model param0.00.10.1-0.2-0.1-0.4-0.3-0.00.1-0.20.3-0.3-0.3-0.10.10.2-0.00.3
Intermittent access intake day 1-15 change0.20.92.61.5-1.01.61.61.1-1.00.5-0.5-0.20.2-1.60.10.10.4-0.7
Intermittent access intake escalation0.21.13.11.7-1.21.81.81.2-1.10.8-0.8-0.30.5-1.6-0.1-0.20.0-0.4
Intermittent access intake escalation 20.91.44.21.9-1.32.12.01.3-1.10.8-0.9-0.30.4-1.80.00.00.1-0.7
Intermitt. access day 1 inactive lever presses0.00.41.41.2-0.50.90.90.6-0.60.3-0.3-0.30.2-1.0-0.00.00.2-0.3
Intermitt. access day 15 inactive lever presses0.10.30.6-0.40.6-0.5-0.4-0.40.5-0.80.70.6-0.8-0.10.70.80.4-0.4
Intermitt. access escalation Index0.10.30.5-0.70.6-0.7-0.7-0.50.6-0.60.60.3-0.50.60.40.40.6-0.5
Intermittent access day 1 total infusions0.20.72.0-1.41.0-1.2-1.2-0.90.9-0.70.70.5-0.51.00.30.30.30.1
Intermittent access day 15 total infusions0.00.00.10.0-0.20.40.40.2-0.10.1-0.20.10.1-0.30.00.00.10.0
Intermittent access terminal intake (last 3 days)0.00.00.2-0.50.2-0.1-0.1-0.20.3-0.20.10.3-0.10.20.20.20.2-0.1
Intermittent access total infusions0.70.92.0-1.41.1-1.1-1.1-1.11.1-0.90.81.0-0.61.10.70.60.6-0.2
Intermittent access day 1 locomotion0.20.41.1-1.10.7-0.9-1.0-0.60.6-0.30.30.4-0.00.9-0.1-0.1-0.30.6
Intermittent access day 15 total locomotion0.10.20.7-0.1-0.1-0.2-0.20.2-0.30.4-0.4-0.30.70.3-0.7-0.8-0.50.8
Intermittent access total locomotion0.40.41.3-1.10.5-0.9-1.0-0.60.5-0.20.10.20.21.1-0.3-0.3-0.50.9
Intermittent access standard deviation0.31.33.1-0.30.8-0.1-0.2-1.11.2-1.31.11.6-1.4-0.01.81.71.2-1.5
Left kidney weight1.310.815.1-3.93.9-3.6-3.6-3.53.6-3.63.43.6-3.02.93.02.92.4-1.7
Right kidney weight1.913.119.2-4.44.3-4.3-4.2-3.94.0-3.93.73.8-3.13.63.12.82.5-1.4
Cocaine induced anxiety0.10.20.50.7-0.50.60.60.4-0.40.2-0.2-0.40.0-0.7-0.10.0-0.10.1
Post-drug Anxiety1.11.22.50.9-1.11.00.70.7-0.71.3-1.4-0.71.4-0.1-1.2-1.2-1.61.4
Baseline Anxiety0.20.41.2-0.3-0.00.0-0.3-0.30.30.6-0.80.40.81.1-0.6-0.8-1.00.8
Tail length0.42.35.3-1.91.9-1.9-2.0-1.71.7-1.31.21.8-0.82.30.90.60.50.1
Length with tail0.10.61.8-0.90.7-0.9-1.1-0.50.5-0.0-0.10.50.51.3-0.5-0.6-1.01.3
Length without tail0.42.34.61.1-1.31.11.01.4-1.31.7-1.7-1.11.7-0.8-1.8-1.6-2.22.0
Times rat made contact with spout1.82.04.4-0.41.3-0.3-0.3-1.31.3-1.51.51.5-1.8-0.01.92.01.6-2.1
Lifetime Intake1.11.42.5-1.61.4-1.4-1.4-1.31.3-1.21.11.2-0.91.30.90.80.8-0.4
Liver weight, left0.20.31.6-0.1-0.2-0.7-0.30.8-0.70.00.3-1.30.0-0.5-0.4-0.40.2-0.3
Liver weight, right0.10.30.8-0.0-0.1-0.6-0.20.5-0.5-0.30.6-0.9-0.4-0.80.00.10.7-0.7
Locomotor activity0.10.20.8-0.60.4-0.9-0.7-0.20.1-0.40.5-0.3-0.30.10.10.10.1-0.2
Locomotor testing distance0.10.30.9-0.90.6-0.9-0.9-0.60.5-0.50.50.2-0.30.50.20.20.2-0.1
Locomotor testing rearing0.00.20.6-0.5-0.1-0.6-0.50.1-0.20.2-0.1-0.80.30.2-0.6-0.6-0.50.4
Locomotion in novel chamber0.40.61.9-1.10.5-1.3-1.3-0.60.6-0.40.50.1-0.21.4-0.0-0.1-0.00.6
Locomotion in novel chamber post-restriction0.51.44.1-0.1-0.7-0.1-0.30.6-0.51.2-1.2-0.91.50.6-1.6-1.6-2.02.0
Fecal boli incidents, locomotor time 10.20.62.00.8-1.00.60.81.0-1.10.6-0.4-1.40.2-1.2-0.5-0.3-0.0-0.1
Change in fecal boli incidents, locomotor task1.11.25.3-1.20.7-0.8-1.2-1.01.00.3-0.50.90.92.3-0.7-1.0-1.11.4
Time >=10cm from walls, locomotor time 10.10.10.5-0.30.30.0-0.1-0.30.7-0.30.20.6-0.40.10.50.5-0.1-0.0
Bouts of movement, locomotor time 12.53.24.82.2-2.01.71.92.2-2.11.8-1.7-2.11.6-1.9-1.6-1.6-1.20.7
Total resting periods, locomotor time 13.23.65.72.3-2.11.92.02.4-2.31.9-1.8-2.31.7-2.0-1.7-1.7-1.00.5
Rest time, locomotor task time 11.01.63.31.8-1.51.71.81.3-1.31.2-1.1-1.10.9-1.8-0.8-0.7-0.70.2
Distance moved, locomotor task time 10.71.93.9-2.01.6-2.0-2.0-1.51.5-1.31.21.2-0.81.90.80.60.7-0.1
Vertical activity count, locomotor time 10.42.84.9-1.71.9-1.4-1.5-2.02.1-1.71.52.2-1.41.81.61.41.2-0.9
Time >=10cm from walls, locomotor time 20.61.72.8-1.21.5-1.0-1.0-1.31.5-1.51.41.7-1.50.81.51.50.9-0.9
Bouts of movement, locomotor time 20.20.71.8-0.30.1-0.4-0.2-0.10.2-0.91.2-0.5-1.4-1.01.01.21.1-1.3
Total resting periods, locomotor time 20.20.92.2-0.40.3-0.6-0.4-0.30.5-1.11.3-0.2-1.5-0.81.11.41.3-1.3
Rest time, locomotor task time 20.10.20.4-0.2-0.20.30.10.0-0.10.5-0.60.00.60.3-0.5-0.5-0.60.6
Distance moved, locomotor task time 20.91.12.1-0.21.1-0.3-0.2-0.70.9-1.21.11.4-1.2-0.11.41.41.4-1.4
Vertical activity count, locomotor time 20.20.52.4-0.20.80.1-0.1-0.80.8-0.60.41.5-0.50.50.90.80.4-0.5
Light reinforcement 10.21.02.80.4-1.20.50.30.5-0.41.2-1.2-1.21.10.3-1.2-1.1-1.51.7
Light reinforcement 20.10.31.3-0.3-0.4-0.1-0.30.2-0.10.5-0.5-0.50.60.5-0.7-0.7-0.91.1
Bone: marrow area1.74.05.9-1.92.1-2.0-1.8-2.01.9-2.42.41.5-2.40.92.22.22.1-2.0
Bone: maximum diameter2.24.46.3-2.22.5-2.2-2.2-2.32.5-2.42.32.0-2.21.42.12.11.4-1.3
Bone: maximum force3.56.810.0-2.83.1-2.5-2.6-3.13.2-2.82.63.1-2.52.22.52.51.7-1.4
Bone: maximum moment3.05.68.4-2.72.8-2.4-2.5-2.82.9-2.52.32.7-2.12.32.12.11.4-1.1
Mean time between licks in bursts0.10.30.80.8-0.90.70.70.6-0.60.5-0.4-0.80.2-0.9-0.3-0.1-0.1-0.2
Mean num. licks in bursts3.08.210.5-3.13.2-3.2-3.1-3.23.2-3.13.02.8-2.72.82.62.42.3-1.7
Cd content in liver2.02.35.2-0.0-1.3-0.3-0.41.0-1.01.5-1.5-1.71.91.2-2.1-2.3-1.92.2
Co content in liver0.40.51.5-0.00.10.2-0.1-0.20.20.5-0.80.80.91.2-0.6-0.8-0.91.1
Cu content in liver0.91.12.6-1.41.2-1.5-1.5-1.21.1-1.00.91.0-0.51.60.60.40.4-0.0
Fe content in liver0.20.30.70.3-0.30.30.20.4-0.40.6-0.70.00.90.4-0.7-0.8-0.60.6
K content in liver0.10.10.3-0.50.3-0.5-0.5-0.50.5-0.30.30.2-0.30.60.20.20.0-0.3
Mg content in liver0.10.10.2-0.30.1-0.4-0.4-0.20.2-0.40.5-0.1-0.5-0.00.30.40.2-0.4
Mn content in liver0.80.91.6-0.61.0-0.8-0.6-0.80.7-1.11.20.6-1.20.01.11.11.2-1.2
Na content in liver4.14.68.1-1.31.9-1.4-1.3-2.32.2-2.52.61.6-2.80.12.72.82.3-2.6
Rb content in liver3.74.39.90.3-1.30.2-0.11.2-1.32.2-2.4-1.32.91.7-2.9-3.1-3.03.1
Se content in liver0.30.30.80.10.5-0.1-0.0-0.40.4-0.60.60.7-0.7-0.20.70.80.8-0.9
Sr content in liver1.41.22.6-0.81.0-1.0-0.7-0.90.9-1.31.40.5-1.40.21.31.31.6-1.5
Zn content in liver1.82.13.6-1.71.5-1.9-1.8-1.61.5-1.71.70.9-1.61.01.31.31.0-0.6
Bone: minimum diameter1.93.64.8-1.82.1-1.7-1.7-2.12.2-2.22.21.7-2.20.82.12.21.4-1.5
Time in familiar zone, hab. session 10.40.41.10.2-0.30.30.30.5-0.50.8-0.8-0.21.00.3-0.9-1.0-0.40.7
Time in novel zone, hab. session 10.30.30.8-0.30.3-0.5-0.5-0.50.6-0.70.80.2-0.9-0.20.70.80.3-0.4
Total zone transitions, hab. session 11.82.65.3-1.91.9-1.6-1.9-2.22.2-1.21.02.2-0.82.30.90.80.10.2
Total locomotion distance, hab. session 14.56.412.3-3.33.1-2.8-3.2-3.33.3-2.11.73.0-1.43.51.51.30.4-0.1
Locomotion velocity, hab. session 13.65.110.6-3.02.7-2.6-3.0-3.03.0-1.81.52.5-1.23.31.21.10.10.0
Time in familiar zone, hab. session 20.30.40.7-0.70.7-0.7-0.7-0.70.7-0.60.60.8-0.50.70.50.40.4-0.0
Time in novel zone, hab. session 20.00.00.20.1-0.2-0.00.00.2-0.30.2-0.1-0.40.2-0.1-0.2-0.3-0.10.1
Total zone transitions, hab. session 21.72.14.6-2.01.7-1.7-2.0-2.01.9-1.10.91.6-0.72.10.60.6-0.20.4
Total locomotion distance, hab. session 22.43.16.8-2.32.1-1.7-2.2-2.52.4-1.31.12.2-0.92.61.00.90.1-0.1
Locomotion velocity, hab. session 22.73.77.1-2.52.3-1.9-2.3-2.72.6-1.61.32.3-1.22.61.21.20.2-0.2
Novel to familiar place preference ratio0.60.81.20.8-0.70.90.80.8-0.81.0-1.1-0.41.0-0.5-0.9-0.9-1.11.0
Novelty place preference0.70.91.51.0-0.81.21.00.8-0.91.1-1.2-0.41.1-0.6-0.9-0.9-1.10.9
Time in novel zone, NPP test0.70.91.50.8-0.71.00.80.8-0.81.1-1.2-0.41.2-0.4-1.0-1.0-1.21.1
Total zone transitions, NPP test1.11.63.0-1.51.5-1.2-1.4-1.71.7-1.11.01.6-0.91.61.00.90.4-0.2
Total locomotion distance, NPP test1.31.83.8-1.51.6-1.0-1.4-1.91.9-1.00.81.9-0.81.81.00.90.2-0.3
Locomotion velocity, NPP test1.01.53.2-1.31.5-0.8-1.2-1.71.8-0.90.71.8-0.71.60.90.90.2-0.3
Intraocular pressure0.20.30.6-0.60.6-0.8-0.7-0.50.5-0.70.70.5-0.60.40.60.60.4-0.1
Delta distance traveled before/after self-admin0.80.91.5-0.81.0-1.0-0.8-0.80.9-1.11.20.6-1.10.41.01.01.1-0.8
Delta ambulatory time before/after self-admin1.01.62.6-0.91.3-1.1-1.0-1.21.2-1.51.61.0-1.50.51.51.51.6-1.3
Parametrial fat weight2.45.513.9-3.52.7-3.6-3.6-2.52.5-1.81.71.7-0.93.70.70.30.21.0
Pavlov. Cond. lever latency1.01.33.50.2-0.30.50.20.2-0.31.2-1.60.61.81.2-1.4-1.6-1.61.9
Pavlov. Cond. magazine entry latency3.84.88.9-1.81.9-2.2-1.8-1.81.7-2.63.00.5-3.00.22.52.62.7-2.4
Pavlov. Cond. change in total contacts2.62.88.7-0.10.8-0.4-0.0-0.60.6-1.72.1-0.1-2.4-1.42.12.42.5-3.0
Pavlov. Cond. index score2.22.76.0-0.91.0-1.3-0.8-0.80.8-1.92.3-0.3-2.5-0.82.02.22.3-2.4
Pavlov. Cond. latency score1.92.45.1-0.91.0-1.3-0.9-0.80.8-1.82.2-0.2-2.3-0.61.82.02.1-2.1
Pavlov. Cond. lever contacts2.12.65.7-0.91.0-1.2-0.9-0.90.9-1.92.2-0.1-2.4-0.71.92.22.1-2.2
Pavlov. Cond. magazine entry number2.32.96.40.8-1.11.20.81.0-1.02.0-2.4-0.12.50.7-2.1-2.3-2.42.3
Pavlov. Cond. intertrial magazine entries2.02.45.10.6-1.00.70.41.0-1.01.8-2.0-0.72.20.5-2.1-2.2-2.32.2
Pavlov. Cond. lever-magazine prob. diff.2.73.37.1-1.01.1-1.5-1.0-1.01.0-2.12.5-0.2-2.7-0.72.22.42.5-2.6
Pavlov. Cond. response bias2.63.27.4-0.61.0-1.0-0.6-1.00.9-2.12.4-0.0-2.7-1.02.32.52.5-2.7
Pavlov. Cond. lever latency1.21.74.51.8-1.72.12.01.2-1.21.3-1.3-1.00.9-1.4-0.7-0.6-0.3-0.3
Pavlov. Cond. magazine entry latency0.50.72.21.3-0.80.81.11.2-1.20.4-0.2-1.00.1-1.5-0.2-0.10.2-0.4
Pavlov. Cond. change in total contacts0.41.13.8-1.00.3-1.1-1.2-0.00.00.4-0.4-0.20.91.4-1.1-1.2-1.51.9
Pavlov. Cond. index score0.10.10.7-0.40.4-0.8-0.60.1-0.1-0.30.4-0.1-0.20.2-0.1-0.1-0.00.4
Pavlov. Cond. latency score0.10.10.5-0.30.4-0.7-0.50.0-0.0-0.40.5-0.0-0.30.10.20.20.20.0
Pavlov. Cond. lever contacts1.11.64.5-1.71.6-2.1-1.9-1.11.1-1.31.40.9-1.01.20.70.60.40.3
Pavlov. Cond. magazine entry number1.31.73.1-1.41.4-1.1-1.3-1.81.7-1.31.21.6-1.11.31.21.20.9-0.7
Pavlov. Cond. intertrial magazine entries1.63.54.9-2.21.9-2.2-2.1-2.12.1-2.02.11.4-1.91.41.71.71.4-1.1
Pavlov. Cond. lever-magazine prob. diff.0.00.10.4-0.20.2-0.6-0.40.3-0.3-0.20.3-0.3-0.1-0.1-0.1-0.10.00.2
Pavlov. Cond. response bias0.20.31.4-0.80.7-1.2-1.0-0.20.2-0.50.60.0-0.30.50.0-0.0-0.10.5
Time in closed arm before self-admin0.00.00.1-0.30.3-0.3-0.3-0.20.2-0.10.10.3-0.00.2-0.0-0.0-0.20.2
Time in closed arm after self-admin0.20.20.30.5-0.40.50.50.5-0.30.5-0.6-0.20.6-0.2-0.4-0.5-0.20.4
Time in open arm before self-admin0.91.12.21.4-1.51.31.41.2-1.21.0-1.0-1.20.7-1.2-0.7-0.6-0.70.2
Time in open arm after self-admin2.42.74.0-1.31.6-1.3-1.2-1.71.5-1.91.91.6-2.00.62.02.01.8-1.6
Bone: periosteal estimation3.27.710.2-2.83.2-2.7-2.7-3.03.1-3.23.12.8-3.01.72.92.92.1-1.9
Bone: periosteal perimeter1.52.94.1-1.81.9-1.9-1.9-1.92.0-2.02.01.4-1.90.91.71.81.1-1.1
Bone: post-yield work2.54.38.7-2.82.4-3.0-2.8-2.22.1-2.12.21.1-1.72.31.41.31.4-1.3
Progressive ratio test 1 active lever presses0.20.40.6-0.80.6-0.7-0.6-0.70.5-0.70.70.2-0.70.30.50.50.7-0.4
Progressive ratio test 1 breakpoint0.20.30.5-0.70.6-0.6-0.5-0.60.5-0.60.70.1-0.60.20.40.50.7-0.4
Progressive ratio test 1 inactive lever presses0.00.10.3-0.00.3-0.3-0.1-0.00.1-0.40.5-0.1-0.5-0.30.30.40.6-0.3
Progressive ratio test 2 active lever presses0.00.00.1-0.20.2-0.4-0.2-0.0-0.1-0.10.2-0.3-0.1-0.0-0.1-0.10.20.0
Progressive ratio test 2 breakpoint0.00.00.2-0.10.1-0.4-0.20.0-0.1-0.00.1-0.40.00.0-0.2-0.20.00.1
Progressive ratio test 2 inactive lever presses0.10.40.8-0.80.8-0.9-0.8-0.40.5-0.70.80.3-0.60.30.50.50.6-0.2
Incentive Sensitization - Responses0.00.00.20.30.0-0.10.00.2-0.2-0.10.2-0.4-0.2-0.30.00.10.3-0.3
Incentive Sensitization - Breakpoint0.00.00.10.10.1-0.3-0.10.1-0.2-0.10.3-0.3-0.1-0.1-0.0-0.00.2-0.1
Sum of active levers in priming session hrs 5-61.11.03.50.7-1.10.40.41.0-1.01.0-0.8-1.90.8-0.7-1.2-1.0-1.10.8
Progressive ratio0.10.31.3-0.60.2-0.4-0.6-0.10.30.3-0.4-0.10.61.1-0.6-0.7-0.60.7
Food seeking constrained by brief footshock0.81.01.51.2-1.11.00.91.1-1.11.1-1.2-0.71.1-0.6-1.0-1.1-0.70.8
Seeking ratio, punishment vs. effort0.20.40.90.5-0.10.20.4-0.0-0.1-0.50.60.2-0.8-1.00.80.90.9-0.8
Retroperitoneal fat weight1.56.518.5-4.12.5-4.2-4.3-2.32.3-1.21.20.8-0.14.2-0.4-0.6-1.12.5
Reaction time number correct0.20.92.20.8-1.10.50.61.1-1.10.9-0.8-1.50.9-0.7-1.1-1.0-0.80.7
Reaction time mean minus median0.00.20.4-0.50.7-0.6-0.5-0.40.4-0.60.60.6-0.50.30.50.40.50.0
Reaction time mean minus median AUC0.00.20.8-0.30.0-0.5-0.40.3-0.30.1-0.1-0.20.40.3-0.4-0.6-0.20.9
Reaction time num false alarms0.40.72.11.2-0.71.51.40.8-0.80.7-0.7-0.20.4-1.1-0.2-0.1-0.4-0.2
Reaction time num false alarms AUC0.20.51.41.0-0.61.21.10.6-0.70.5-0.5-0.30.2-1.0-0.10.0-0.3-0.3
Reaction time trials correct on left0.20.92.20.8-1.10.50.61.1-1.10.9-0.8-1.50.9-0.7-1.1-1.0-0.80.7
Reaction time trials on left0.30.92.30.7-1.10.40.51.1-1.20.9-0.8-1.50.9-0.7-1.1-1.0-0.80.7
Reaction time mean0.20.51.1-1.10.9-1.0-0.9-0.50.5-0.80.90.6-0.60.50.60.50.7-0.0
Reaction time mean AUC0.10.20.5-0.70.5-0.7-0.5-0.20.2-0.60.60.2-0.40.10.40.30.5-0.0
Median of all reaction times0.40.51.2-1.10.8-1.1-0.9-0.50.5-0.90.90.5-0.70.50.60.50.8-0.2
Reaction time omissions0.10.21.1-0.1-0.3-0.4-0.10.6-0.60.10.1-1.00.0-0.5-0.3-0.3-0.30.4
Reaction time false alarm rate0.20.31.00.6-0.11.00.90.1-0.1-0.1-0.00.5-0.3-0.80.60.60.2-0.8
Reaction time premature initiation rate1.42.23.5-0.81.3-0.8-0.7-1.51.5-1.71.61.7-1.70.51.91.81.8-1.6
Reaction time premature initiations0.20.61.4-0.20.4-0.2-0.2-0.70.7-0.90.90.6-1.1-0.11.11.11.2-1.1
Std. dev. reaction times0.10.41.0-1.00.8-1.0-0.9-0.50.5-0.60.60.6-0.40.70.30.20.20.5
Reaction time trials completed0.30.92.30.7-1.10.40.51.1-1.20.9-0.8-1.50.9-0.7-1.1-1.0-0.80.7
Reaction time trials AUC0.20.61.70.5-0.80.20.30.9-0.90.8-0.6-1.30.7-0.5-0.9-0.9-0.70.7
Run reversals in cocaine runway, females5.86.59.7-1.82.7-1.9-1.7-2.52.4-3.02.93.0-2.91.13.12.92.9-2.6
Run reversals in cocaine runway, males0.50.51.01.0-0.81.01.00.8-0.80.7-0.7-0.50.6-0.8-0.5-0.5-0.20.2
Latency to leave start box in cocaine runway0.70.93.3-0.5-0.3-0.3-0.50.1-0.20.8-0.9-0.21.20.9-1.2-1.3-1.61.8
Latency to leave start box in cocaine runway, F0.30.31.1-0.1-0.5-0.1-0.10.3-0.60.5-0.5-0.60.60.0-0.8-0.7-0.91.0
Latency to leave start box in cocaine runway, M0.70.72.0-0.60.1-0.3-0.6-0.10.20.6-0.80.21.11.4-1.0-1.2-1.21.4
Std. dev. time between licks in bursts0.10.10.4-0.2-0.2-0.3-0.3-0.20.2-0.40.5-0.3-0.6-0.10.40.50.4-0.4
Total sessions with >9 infusions4.96.19.0-2.92.9-3.0-2.9-2.72.7-2.62.62.3-2.22.52.11.92.0-1.2
Short access day 1 total inactive lever presses0.20.40.6-0.50.7-0.6-0.6-0.80.7-0.70.70.7-0.60.50.60.60.4-0.2
Short access day 10 total inactive lever presses0.31.94.82.2-1.51.81.81.5-1.51.2-1.2-1.10.9-1.9-0.8-0.6-0.70.3
Short access day 1 total infusions1.02.03.2-1.51.8-1.7-1.6-1.31.4-1.61.61.5-1.31.11.31.11.4-0.9
Short access day 10 total infusions1.82.93.8-1.82.0-2.0-1.8-1.71.7-1.91.91.4-1.71.31.61.51.7-1.3
Short access total infusions2.83.95.7-2.32.3-2.4-2.3-2.22.2-2.12.01.9-1.72.01.71.51.6-1.1
Short access day 1 locomotion0.40.71.4-0.71.0-0.8-0.7-0.70.6-0.90.91.2-0.70.40.90.71.0-0.6
Short access day 10 total locomotion0.93.85.6-1.71.9-1.8-1.8-2.42.1-2.22.21.7-2.31.42.22.21.7-1.4
Short access total locomotion2.43.66.2-2.52.1-2.4-2.5-2.42.2-1.81.61.9-1.32.51.31.10.9-0.2
One hour access (0.3 mA shock)0.10.10.3-0.50.2-0.5-0.40.00.1-0.10.2-0.40.00.4-0.2-0.20.10.1
Compulsive drug intake0.10.20.4-0.60.0-0.6-0.5-0.20.10.10.0-0.50.10.6-0.4-0.4-0.40.6
One hour access (shock baseline)0.00.10.20.2-0.20.40.30.4-0.30.3-0.4-0.20.4-0.3-0.3-0.3-0.20.1
Social response proportion0.20.20.6-0.50.1-0.8-0.60.3-0.30.2-0.1-0.60.40.4-0.7-0.7-0.20.7
Social responses0.60.82.20.5-0.90.40.41.0-1.01.0-0.8-1.50.9-0.7-1.2-1.0-0.90.9
Social time0.91.42.40.6-1.10.70.61.1-1.11.4-1.3-1.21.5-0.4-1.5-1.5-1.41.4
Soleus weight2.77.913.9-3.23.5-3.0-3.1-3.23.2-2.92.63.7-2.22.92.42.11.8-0.9
Bone: stiffness2.54.57.9-2.02.7-1.8-1.9-2.52.6-2.32.12.8-2.01.52.12.11.3-1.2
Tibialis anterior weight6.622.931.7-4.85.6-4.8-4.8-5.65.6-5.24.95.6-4.64.04.74.43.7-2.5
Time to tail flick, vehicle, before self-admin0.10.20.3-0.40.5-0.3-0.4-0.50.6-0.40.40.5-0.40.40.40.40.0-0.3
Time to tail flick, vehicle, after self-admin2.04.16.41.9-2.11.81.72.1-2.12.2-2.1-2.52.0-1.7-2.2-2.0-2.11.5
Time to tail flick, test, before self-admin0.20.20.50.20.30.00.1-0.20.0-0.50.50.5-0.6-0.50.60.70.6-0.7
Time to tail flick, test, after self-admin1.11.13.91.1-0.30.81.10.6-0.5-0.50.7-0.4-1.0-2.01.01.21.3-1.8
Delta time to tail flick, vehicle, before/after SA0.60.71.40.4-0.70.30.20.7-0.70.9-0.8-1.20.9-0.2-1.1-1.0-1.01.0
Delta time to tail flick, test, before/after SA0.20.30.8-0.20.3-0.2-0.1-0.10.3-0.60.7-0.0-0.7-0.30.70.70.8-0.9
Tibia length0.10.21.1-0.60.6-0.5-0.6-0.30.3-0.1-0.00.50.31.0-0.2-0.3-0.30.5
Ambulatory time before self-admin0.00.10.50.3-0.00.60.40.0-0.00.3-0.50.70.40.2-0.1-0.2-0.20.2
Ambulatory time after self-admin1.52.44.4-0.81.5-0.7-0.7-1.61.5-1.71.62.1-1.70.72.01.91.9-1.6
Bone: tissue strength0.10.10.4-0.10.40.10.1-0.30.3-0.30.30.6-0.4-0.00.50.50.4-0.6
Total heroin consumption0.70.92.40.3-0.80.30.20.8-0.81.0-0.9-1.51.0-0.3-1.3-1.2-1.21.1
Bone: trabecular number0.61.12.0-1.41.2-0.9-1.1-1.41.3-0.90.71.4-0.71.30.80.70.4-0.2
Bone: trabecular spacing0.60.82.41.1-1.10.50.81.4-1.30.5-0.2-1.60.2-1.5-0.5-0.40.1-0.3
Bone: trabecular thickness2.23.010.1-2.52.0-2.0-2.4-2.02.0-0.80.51.80.03.20.1-0.2-0.71.2
Bone: trabecular tissue density0.10.10.40.20.00.40.2-0.00.10.3-0.50.30.4-0.0-0.3-0.2-0.60.4
Water consumed over 24 hours0.71.34.61.5-0.41.61.70.7-0.70.00.00.0-0.5-1.90.70.91.2-2.1
Number of responses in last shaping day0.20.30.7-0.60.6-0.4-0.3-0.30.4-0.60.60.4-0.6-0.00.50.60.8-0.7