Hub : Traits

Length with tail

Tags: Physiology

Project: dissection

1973 significantly associated models · 341 unique genes

Significant Loci

# chr p0 p1 # assoc genes # joint models best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 82883896 87558983 82 9 1.7e-09 3.7e-09 1.0e+00 100 Ech1 Actn4 Sipa1l3 Cd22 Fam98c U2af1l4 Dmkn NA Capns1
2 1 233061060 234537919 3 1 9.2e-10 2.3e-08 1.9e-35 -394 NA
3 2 33156304 36920918 16 2 4.0e-12 3.7e-12 1.0e+00 100 Nln Shisal2b
4 2 43366934 44763574 1 1 2.8e-08 5.3e-05 9.5e-02 83 Il6st
5 3 122254021 123489307 1 1 1.5e-07 1.8e-06 5.6e-01 98 Plcb4
6 5 20704626 22101976 1 1 1.5e-07 5.8e-08 1.0e+00 100 Ca8
7 6 60630015 62029190 1 1 6.7e-10 8.1e-07 5.9e-01 99 Pnpla8
8 6 100080023 101706303 4 1 3.4e-08 7.1e-08 7.6e-24 -249 Smoc1
9 6 130177816 132888501 23 1 2.8e-11 4.6e-10 7.6e-01 100 Tedc1
10 7 26575816 30904027 24 6 4.5e-23 5.0e-25 NaN NaN Lta4h Hal Ntn4 Ndufa12 Tmcc3 Socs2
11 8 108584253 112100485 48 10 8.0e-11 5.2e-10 1.0e+00 100 Camp Map4 Cspg5 Setd2 Pth1r Nbeal2 Dclk3 Mlh1 Rtp3 Epm2aip1
12 9 49427717 51433051 2 1 4.4e-09 2.1e-09 1.0e+00 100 Tmeff2
13 9 52642068 54039163 1 1 6.8e-08 1.5e-09 1.0e+00 100 NA
14 9 54140250 57601104 19 1 8.2e-14 8.2e-14 1.0e+00 100 Hecw2
15 9 58279121 60963686 7 4 1.1e-08 5.8e-09 1.0e+00 100 Nif3l1 Aox4 Maip1 Kctd18
16 9 67025649 69247638 8 5 4.9e-12 5.0e-13 0.0e+00 -2663 Map2 Acadl Unc80 NA NA
17 10 10636724 12227767 2 1 9.6e-08 7.4e-07 4.8e-03 68 Crebbp
18 10 79556862 83457143 39 5 1.0e-14 7.9e-15 1.0e+00 100 Phospho1 Nfe2l1 Mrpl45 Npepps Psmb3
19 12 27006 8298962 45 4 1.1e-21 1.4e-19 NaN NaN Camsap3 Trappc5 Timm44 Insr
20 19 27506939 28903917 1 1 3.5e-07 1.5e-07 1.0e+00 100 Anapc10
21 20 2357921 3884026 12 1 7.7e-08 3.8e-06 8.3e-01 100 AABR07044375.1

p0: physical position of the start of the locus. p1: physical position of the end of the locus. # joint models: number of models selected by step-wise conditional analysis.

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
BMI with tail 12.7 41 33 56.9 -0.95 1.7e-72 Spop Ttll6 Phospho1 Abi3 Gip Snf8 Ube2z Atp5mc1 Hoxb3 NA Snx11 Cbx1 Nfe2l1 Copz2 Kpnb1 Tbkbp1 Osbpl7 Mrpl10 Lrrc46 Scrn2 Sp2 Mrpl45 Srcin1 Aox4 Nabp1 Tmeff2 Zfp652 Kat7 Npepps Sp6 Skap1 Kctd18 Unc80 Lrrc8e Pnpo Phb Cdk5rap3 Prr15l B4galnt2 Atp5mc1 NA
BMI without tail 8.9 4 0 0.0 1.00 7.7e-06 Lta4h Hal Vezt Metap2
Body weight 9.4 129 110 189.7 0.99 0.0e+00 RT1-S3 RT1-N3 Abcf1 Gtf2h4 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Slc7a1 Mcoln1 Pnpla6 Camsap3 Xab2 Pcp2 Stxbp2 Retn Trappc5 Evi5l Map2k7 Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Nedd1 Cwc25 Cdk17 Elk3 Lta4h Hal Amdhd1 Snrpf Ntn4 Vezt Nr2c1 Ndufa12 Tmcc3 Cep83 Plxnc1 Cradd Socs2 Nudt4 Srcin1 Pip4k2b Il6st P4htm Prkar2a Slc26a6 Col7a1 Pfkfb4 Shisa5 Atrip Ccdc51 Nme6 Camp Cdc25a Map4 Smarcc1 Cspg5 Elp6 Scap Ptpn23 Klhl18 Kif9 Setd2 Ccdc12 Pth1r Myl3 Lrrfip2 Trank1 Metap2 Ccdc38 Trex1 Npepps Ngp AABR07056633.1 Tmie Nbeal2 Arhgef18 Pex11g Mcemp1 Lrrc8e Plxnb1 Insr Dhx16 Lrrc2 AC107280.1 NA Nckipsd Impdh2 Uqcrc1 RT1-T24-1 Dclk3 Mlh1 Als2cl Mir331 Cisd3 Rtp3 Prss50 RT1-T24-4 Epm2aip1 NA Tma7 Katnal1 Clip3 Pet100 AABR07044375.1 Psmb3 Celsr3 Fgd6 NA Ddr1 Ube2n N4bp2l1 B3glct RT1-T18 NA NA Zfp958 NA NA NA NA NA
Epididymis fat weight 9.8 1 0 0.0 0.00 1.0e+00 Map2
Left kidney weight 9.9 36 25 43.1 1.00 2.4e-196 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Arhgef18 Pex11g Mcemp1 Lrrc8e Insr Katnal1 Pet100 N4bp2l1 B3glct NA Zfp958 NA NA NA NA
Right kidney weight 8.5 53 24 41.4 0.99 1.0e-165 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Slc7a1 Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Pds5b N4bp2l2 Brca2 Zfp382 Lrfn3 Aplp1 Kirrel2 Hspb6 Tmem147 Sbsn Mag Fxyd5 Hpn Cd22 Haus5 U2af1l4 Proser3 Alkbh6 Arhgef18 Mcemp1 Lrrc8e Insr Katnal1 Syne4 Pet100 Dmkn N4bp2l1 B3glct NA Zfp958 NA Capns1 NA NA NA
Tail length 8.9 253 128 220.7 0.98 0.0e+00 RT1-S3 RT1-N3 Abcf1 Gtf2h4 Zfp958l1 Rxfp2 Slc7a1 Slc46a3 Pan3 Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Gtf3c3 Nedd1 Cwc25 Cdk17 Elk3 Lta4h Hal Galnt16 Spop Ttll6 Crip2 Amdhd1 Snrpf Phospho1 Ntn4 Abi3 Smoc1 Gip Snf8 Vezt Ube2z Nr2c1 Atp5mc1 Ndufa12 Tmcc3 Cep83 Plxnc1 Hoxb3 NA Cradd Snx11 Cbx1 Nfe2l1 Socs2 Nudt4 Copz2 Kpnb1 Tbkbp1 Osbpl7 Mrpl10 Lrrc46 Scrn2 Sp2 Mrpl45 Srcin1 Nln Slc39a10 Sgtb Trappc13 Casp8 Trim23 Stk17b Adamts6 Acadl Pip4k2b Cwc27 Hecw2 Ccdc150 Shisal2b Pgap1 Rgs7bp Nif3l1 Sf3b1 Lancl1 Clba1 Cdca4 Coq10b Hspd1 Aox4 Brf1 Pacs2 Mob4 Aox1 Nabp1 Rftn2 Maip1 Tmeff2 Zfp652 Anapc10 Rpp30 Htr7 Pde2a P4htm Prkar2a Ech1 Actn4 Slc26a6 Map4k1 Ryr1 Col7a1 Kcnk6 Spint2 Pfkfb4 Shisa5 Atrip Ppp1r14a Dpf1 Ccdc51 Sipa1l3 Nme6 Camp Cdc25a Map4 Zfp382 Polr2i Smarcc1 Cspg5 Elp6 Scap Ptpn23 Klhl18 Kif9 Setd2 Ccdc12 Pth1r Myl3 Lrrfip2 Trank1 Ankrd44 Metap2 Ccdc38 Trex1 Kat7 Npepps Sp6 Skap1 Fam98c Ngp AABR07056633.1 Mast4 Kctd18 Tmie Nbeal2 Arhgef18 Pex11g Kansl1l Mcemp1 Unc80 Lrrc8e Zfp84 Plxnb1 Slc8a3 Insr Dhx16 Lrrc2 Zfp14 AC107280.1 NA Nckipsd Impdh2 Uqcrc1 Mtus2 RT1-T24-1 Plcl1 Srek1 Dclk3 Plcb4 Cep170b Rasgrp4 Mlh1 Als2cl Aox2 Mir331 Cisd3 Rtp3 Prss50 Zfp420 Psmd8 Plekhd1 Cenpk Mrpl42 RT1-T24-4 Epm2aip1 NA Pnpo Zfp84 Phb Erbin Tma7 Srek1ip1 Zfp566 Cdk5rap3 Prr15l Pomp Syne4 Cox7a1 Clip3 Pet100 AABR07044375.1 Spred3 Psmb3 Celsr3 Boll Fgd6 NA Yif1b AABR07002868.1 Ddr1 Ube2n N4bp2l1 Catsperg Dnah7 RT1-T18 NA NA NA NA NA NA NA NA Zfp958 NA Shld3 Capns1 NA B4galnt2 NA NA NA Atp5mc1 NA Zfp74 NA NA NA Tedc1 Zfp27
Length without tail 11.7 64 29 50.0 0.98 3.7e-177 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Slc7a1 Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Retn Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Elk3 Lta4h Amdhd1 Snrpf Ntn4 Vezt Ndufa12 Plxnc1 Cradd Socs2 Trim23 Shisal2b Rgs7bp Il6st Map4 Scn1b Gramd1a Metap2 Trex1 Arhgef18 Mcemp1 Lrrc8e Insr Dclk3 Mir331 Pnpla8 Srek1ip1 Katnal1 Pet100 Fgd6 Dmkn N4bp2l1 B3glct NA NA Zfp958 NA Capns1 NA NA NA
Liver weight, right 11.1 1 0 0.0 0.00 1.0e+00 Rxfp2
Extensor digitorum longus weight 7.8 62 38 65.5 0.91 1.6e-134 Zfp958l1 Fry Rxfp2 Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Map2k7 Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Cwc25 Crip2 Tmem121 Mrpl45 Srcin1 Zfyve21 Pip4k2b NA Tmem179 Cwc27 Rgs7bp Clba1 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Npepps Crip1 Arhgef18 Tex22 Mcemp1 Lrrc8e Pld4 Akt1 Siva1 Inf2 Insr Cep170b Cisd3 Srek1ip1 Pet100 Psmb3 N4bp2l1 NA Zfp958 NA NA NA Tedc1
Soleus weight 7.5 1 0 0.0 0.00 1.0e+00 Ca8
Tibialis anterior weight 7.3 33 19 32.8 0.99 6.0e-166 Zfp958l1 Fry Rxfp2 Mcoln1 Pnpla6 Camsap3 Xab2 Pcp2 Stxbp2 Retn Trappc5 Evi5l Map2k7 Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Arhgef18 Pex11g Mcemp1 Lrrc8e Insr Pnpla8 Pet100 N4bp2l1 Zfp958 NA NA
Tibia length 7.7 94 22 37.9 0.99 0.0e+00 Mcoln1 Stxbp2 Trappc5 Evi5l Snapc2 Pds5b N4bp2l2 Brca2 Nedd1 Cdk17 Elk3 Lta4h Hal Amdhd1 Snrpf Ntn4 Vezt Nr2c1 Ndufa12 Tmcc3 Cep83 Plxnc1 Cradd Socs2 Nln Sgtb Trappc13 Trim23 Stk17b Adamts6 Hecw2 Pgap1 Rgs7bp Sf3b1 Coq10b Hspd1 Prkar2a Slc26a6 Pfkfb4 Shisa5 Atrip Ccdc51 Nme6 Camp Cdc25a Map4 Smarcc1 Cspg5 Elp6 Scap Ptpn23 Klhl18 Kif9 Setd2 Ccdc12 Pth1r Myl3 Lrrfip2 Trank1 Metap2 Ccdc38 Trex1 Ngp AABR07056633.1 Mast4 Tmie Nbeal2 Plxnb1 Insr Lrrc2 AC107280.1 Nckipsd Impdh2 Srek1 Dclk3 Mlh1 Als2cl Mir331 Rtp3 Prss50 Cenpk Epm2aip1 NA Erbin Tma7 Pet100 Celsr3 Fgd6 Usp4 NA NA NA Shld3 NA
Delay discounting time to switch 0 sec 12.8 20 0 0.0 -1.00 5.1e-208 Crip2 Tmem121 NA Tmem179 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Tex22 Pld4 Akt1 Siva1 Inf2 Cep170b NA NA Tedc1
Delay discounting water rate 0 sec 17.6 23 21 36.2 1.00 1.3e-219 Crip2 Tmem121 Zfyve21 NA Tmem179 Clba1 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Crip1 Tex22 Pld4 Akt1 Siva1 Inf2 Cep170b NA NA Tedc1
Delay discounting water rate 12 sec 13.6 1 0 0.0 0.00 1.0e+00 Zfyve21
Delay discounting water rate 6 sec 13.5 15 0 0.0 1.00 6.4e-199 Nln Sgtb Trappc13 Trim23 Adamts6 Cwc27 Shisal2b Rgs7bp Mast4 Srek1 Cenpk Erbin Srek1ip1 NA Shld3
Locomotor activity 14.4 1 0 0.0 0.00 1.0e+00 Pnpla8
Locomotor testing distance 12.4 1 0 0.0 0.00 1.0e+00 Pnpla8
Light reinforcement 1 10.0 1 0 0.0 0.00 1.0e+00 Kctd18
Reaction time num false alarms 22.6 1 1 1.7 0.00 1.0e+00 Slx4
Reaction time num false alarms AUC 20.3 1 1 1.7 0.00 1.0e+00 Slx4
Reaction time premature initiations 12.9 5 0 0.0 1.00 8.3e-16 Trappc13 Cwc27 Shisal2b Rgs7bp Srek1ip1
One hour access (shock baseline) 15.4 1 0 0.0 0.00 1.0e+00 Cradd
Bone: apparent density 12.0 7 0 0.0 0.99 1.3e-29 Zfp958l1 Fry Rxfp2 NA Zfp958 NA NA
Bone surface 11.6 11 1 1.7 0.99 1.6e-28 Zfp958l1 Fry Rxfp2 Snapc2 Elavl1 Cers4 Il6st NA Zfp958 NA NA
Bone volume 11.8 8 0 0.0 1.00 1.7e-26 Zfp958l1 Fry Rxfp2 Il6st NA Zfp958 NA NA
Bone: connectivity density 12.3 10 0 0.0 0.99 1.5e-30 Zfp958l1 Fry Rxfp2 Snapc2 Elavl1 Lrrc8e Pet100 NA Zfp958 NA
Bone: cortical area 13.0 1 0 0.0 0.00 1.0e+00 Il6st
Bone: endosteal estimation 8.3 5 0 0.0 1.00 1.7e-09 RT1-S3 RT1-N3 RT1-T24-1 RT1-T24-4 NA
Bone: final moment 11.4 1 0 0.0 0.00 1.0e+00 Il6st
Bone: maximum force 11.2 1 0 0.0 0.00 1.0e+00 Il6st
Bone: maximum moment 11.4 1 0 0.0 0.00 1.0e+00 Il6st
Bone: periosteal estimation 10.8 1 0 0.0 0.00 1.0e+00 Il6st
Fe content in liver 15.1 1 0 0.0 0.00 1.0e+00 B3glct
Se content in liver 15.1 2 0 0.0 0.00 1.0e+00 Rpp30 Htr7

chisq ratio: Average Chi2 statistic for the selected genes in the secondary trait, divided by the average statistic for all genes in the secondary trait. # genes+: Shared significant genes at Bonferroni correction. # genes++: Shared significant genes at transcriptome-wide significance. % genes++: Number of [++] genes as a percentage of primary trait’s total joint genes. corr: Correlation of effect sizes across the [+] genes.

Associations by panel

tissue modality # hits % hits/tests avg chisq
Adipose alternative polyA 29 1.37 3.9
Adipose alternative TSS 20 1.24 3.6
Adipose gene expression 112 1.35 3.5
Adipose isoform ratio 29 1.03 3.5
Adipose intron excision ratio 22 0.75 3.5
Adipose mRNA stability 46 1.33 3.6
BLA alternative polyA 10 0.83 3.7
BLA alternative TSS 9 1.07 3.6
BLA gene expression 105 1.73 3.7
BLA isoform ratio 25 1.42 4.0
BLA intron excision ratio 35 1.17 3.8
BLA mRNA stability 37 1.83 3.8
Brain alternative polyA 23 1.15 3.7
Brain alternative TSS 28 1.63 3.8
Brain gene expression 126 1.39 3.5
Brain isoform ratio 30 0.95 3.6
Brain intron excision ratio 72 1.33 3.9
Brain mRNA stability 56 1.28 3.5
Eye alternative polyA 2 1.12 3.3
Eye alternative TSS 9 3.75 3.9
Eye gene expression 19 1.69 3.6
Eye isoform ratio 1 0.28 3.9
Eye intron excision ratio 10 1.63 4.1
Eye mRNA stability 6 2.59 3.9
IL alternative polyA 13 2.13 4.2
IL alternative TSS 8 2.77 4.2
IL gene expression 48 1.32 3.6
IL isoform ratio 12 1.52 4.6
IL intron excision ratio 8 0.83 3.5
IL mRNA stability 21 1.89 3.7
LHb alternative polyA 11 1.91 4.3
LHb alternative TSS 1 0.29 3.2
LHb gene expression 45 1.40 3.5
LHb isoform ratio 11 1.46 4.0
LHb intron excision ratio 13 1.26 3.8
LHb mRNA stability 20 1.93 3.7
Liver alternative polyA 11 0.73 3.6
Liver alternative TSS 14 0.92 3.3
Liver gene expression 101 1.40 3.5
Liver isoform ratio 26 1.09 3.4
Liver intron excision ratio 44 1.01 3.5
Liver mRNA stability 42 1.71 3.6
NAcc alternative polyA 20 1.53 3.8
NAcc alternative TSS 15 1.62 3.9
NAcc gene expression 107 1.70 3.8
NAcc isoform ratio 24 1.27 3.9
NAcc intron excision ratio 40 1.31 3.9
NAcc mRNA stability 43 1.90 3.7
OFC alternative polyA 6 1.03 3.6
OFC alternative TSS 5 1.57 3.5
OFC gene expression 57 1.54 3.6
OFC isoform ratio 13 1.59 4.1
OFC intron excision ratio 12 1.19 4.0
OFC mRNA stability 20 1.85 3.7
PL alternative polyA 17 1.19 3.7
PL alternative TSS 19 1.62 4.1
PL gene expression 114 1.54 3.6
PL isoform ratio 35 1.59 4.0
PL intron excision ratio 61 1.70 4.0
PL mRNA stability 55 1.89 3.7

avg chisq: Average Chi2 (squared Z-score) across all models in this panel for this trait.