Length with tail

Tags: Physiology

21 loci · 58 genes with independent associations · 340 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	1	82883896	87558983	82	9	1.74e-09	3.68e-09	1.00e+00	Ech1 Actn4 Sipa1l3 Cd22 Fam98c U2af1l4 Dmkn ENSRNOG00000063599 Capns1
2	1	233061060	234537919	3	1	9.23e-10	2.31e-08	1.92e-35	ENSRNOG00000064807
3	2	33156304	36920918	16	2	4.04e-12	3.69e-12	1.00e+00	Nln Shisal2b
4	2	43366934	44763574	1	1	2.79e-08	5.30e-05	9.51e-02	Il6st
5	3	122254021	123489307	1	1	1.50e-07	1.84e-06	5.56e-01	Plcb4
6	5	20704626	22101976	1	1	1.48e-07	5.78e-08	1.00e+00	Ca8
7	6	60630015	62029190	1	1	6.69e-10	8.06e-07	5.93e-01	Pnpla8
8	6	100080023	101706303	4	1	3.38e-08	7.06e-08	7.57e-24	Smoc1
9	6	130177816	132888501	23	1	2.84e-11	4.61e-10	7.65e-01	Tedc1
10	7	26575816	30904027	24	6	4.49e-23	5.05e-25	NaN	Lta4h Hal Ntn4 Ndufa12 Tmcc3 Socs2
11	8	108584253	112100485	48	10	7.99e-11	5.15e-10	1.00e+00	Camp Map4 Cspg5 Setd2 Pth1r Nbeal2 Dclk3 Mlh1 Rtp3 Epm2aip1
12	9	49427717	51433051	2	1	4.35e-09	2.10e-09	1.00e+00	Tmeff2
13	9	52642068	54039163	1	1	6.82e-08	1.54e-09	1.00e+00	ENSRNOG00000069389
14	9	54140250	57601104	19	1	8.17e-14	8.17e-14	1.00e+00	Hecw2
15	9	58279121	60963686	7	4	1.10e-08	5.75e-09	1.00e+00	Nif3l1 Aox4 Maip1 Kctd18
16	9	67025649	69247638	8	5	4.88e-12	4.98e-13	0.00e+00	Map2 Acadl Unc80 ENSRNOG00000063935 ENSRNOG00000068276
17	10	10636724	12227767	2	1	9.56e-08	7.42e-07	4.79e-03	Crebbp
18	10	79556862	83457143	39	5	1.04e-14	7.90e-15	1.00e+00	Phospho1 Nfe2l1 Mrpl45 Npepps Psmb3
19	12	27006	8298962	45	4	1.05e-21	1.40e-19	NaN	Camsap3 Trappc5 Timm44 Insr
20	19	27506939	28903917	1	1	3.49e-07	1.54e-07	1.00e+00	Anapc10
21	20	2357921	3884026	12	1	7.67e-08	3.78e-06	8.30e-01	AABR07044375.1

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr	Corr P	Genes
BMI with tail	12.66	41	33	56.9	-0.95	1.73e-72	Spop Ttll6 Phospho1 Abi3 Gip Snf8 Ube2z Atp5mc1 Hoxb3 ENSRNOG00000008365 Snx11 Cbx1 Nfe2l1 Copz2 Kpnb1 Tbkbp1 Osbpl7 Mrpl10 Lrrc46 Scrn2 Sp2 Mrpl45 Srcin1 Aox4 Nabp1 Tmeff2 Zfp652 Kat7 Npepps Sp6 Skap1 Kctd18 Unc80 Lrrc8e Pnpo Phb Cdk5rap3 Prr15l B4galnt2 Atp5mc1 ENSRNOG00000069592
BMI without tail	8.92	4	0	0	1	7.72e-06	Lta4h Hal Vezt Metap2
Body weight	9.44	129	110	189.7	0.99	0.00e+00	RT1-S3 RT1-N3 Abcf1 Gtf2h4 Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Slc7a1 Mcoln1 Pnpla6 Camsap3 Xab2 Pcp2 Stxbp2 Retn Trappc5 Evi5l Map2k7 Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Nedd1 Cwc25 Cdk17 Elk3 Lta4h Hal Amdhd1 Snrpf Ntn4 Vezt Nr2c1 Ndufa12 Tmcc3 Cep83 Plxnc1 Cradd Socs2 Nudt4 Srcin1 Pip4k2b Il6st P4htm Prkar2a Slc26a6 Col7a1 Pfkfb4 Shisa5 Atrip Ccdc51 Nme6 Camp Cdc25a Map4 Smarcc1 Cspg5 Elp6 Scap Ptpn23 Klhl18 Kif9 Setd2 Ccdc12 Pth1r Myl3 Lrrfip2 Trank1 Metap2 Ccdc38 Trex1 Npepps Ngp AABR07056633.1 Tmie Nbeal2 Arhgef18 Pex11g Mcemp1 Lrrc8e Plxnb1 Insr Dhx16 Lrrc2 AC107280.1 ENSRNOG00000031607 Nckipsd Impdh2 Uqcrc1 RT1-T24-1 Dclk3 Mlh1 Als2cl Mir331 Cisd3 Rtp3 Prss50 RT1-T24-4 Epm2aip1 ENSRNOG00000046155 Tma7 Katnal1 Clip3 Pet100 AABR07044375.1 Psmb3 Celsr3 Fgd6 ENSRNOG00000054635 Ddr1 Ube2n N4bp2l1 B3glct RT1-T18 ENSRNOG00000064836 ENSRNOG00000065248 Zfp958 ENSRNOG00000065898 ENSRNOG00000067247 ENSRNOG00000068541 ENSRNOG00000068850 ENSRNOG00000070140
Epididymis fat weight	9.78	1	0	0	0	1.00e+00	Map2
Left kidney weight	9.92	36	25	43.1	1	2.44e-196	Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Arhgef18 Pex11g Mcemp1 Lrrc8e Insr Katnal1 Pet100 N4bp2l1 B3glct ENSRNOG00000065248 Zfp958 ENSRNOG00000065898 ENSRNOG00000067247 ENSRNOG00000068541 ENSRNOG00000068850
Right kidney weight	8.49	53	24	41.4	0.99	1.02e-165	Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Slc7a1 Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Pds5b N4bp2l2 Brca2 Zfp382 Lrfn3 Aplp1 Kirrel2 Hspb6 Tmem147 Sbsn Mag Fxyd5 Hpn Cd22 Haus5 U2af1l4 Proser3 Alkbh6 Arhgef18 Mcemp1 Lrrc8e Insr Katnal1 Syne4 Pet100 Dmkn N4bp2l1 B3glct ENSRNOG00000063599 Zfp958 ENSRNOG00000065898 Capns1 ENSRNOG00000067247 ENSRNOG00000068541 ENSRNOG00000069365
Tail length	8.91	253	128	220.7	0.98	0.00e+00	RT1-S3 RT1-N3 Abcf1 Gtf2h4 Zfp958l1 Rxfp2 Slc7a1 Slc46a3 Pan3 Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Gtf3c3 Nedd1 Cwc25 Cdk17 Elk3 Lta4h Hal Galnt16 Spop Ttll6 Crip2 Amdhd1 Snrpf Phospho1 Ntn4 Abi3 Smoc1 Gip Snf8 Vezt Ube2z Nr2c1 Atp5mc1 Ndufa12 Tmcc3 Cep83 Plxnc1 Hoxb3 ENSRNOG00000008365 Cradd Snx11 Cbx1 Nfe2l1 Socs2 Nudt4 Copz2 Kpnb1 Tbkbp1 Osbpl7 Mrpl10 Lrrc46 Scrn2 Sp2 Mrpl45 Srcin1 Nln Slc39a10 Sgtb Trappc13 Casp8 Trim23 Stk17b Adamts6 Acadl Pip4k2b Cwc27 Hecw2 Ccdc150 Shisal2b Pgap1 Rgs7bp Nif3l1 Sf3b1 Lancl1 Clba1 Cdca4 Coq10b Hspd1 Aox4 Brf1 Pacs2 Mob4 Aox1 Nabp1 Rftn2 Maip1 Tmeff2 Zfp652 Anapc10 Rpp30 Htr7 Pde2a P4htm Prkar2a Ech1 Actn4 Slc26a6 Map4k1 Ryr1 Col7a1 Kcnk6 Spint2 Pfkfb4 Shisa5 Atrip Ppp1r14a Dpf1 Ccdc51 Sipa1l3 Nme6 Camp Cdc25a Map4 Zfp382 Polr2i Smarcc1 Cspg5 Elp6 Scap Ptpn23 Klhl18 Kif9 Setd2 Ccdc12 Pth1r Myl3 Lrrfip2 Trank1 Ankrd44 Metap2 Ccdc38 Trex1 Kat7 Npepps Sp6 Skap1 Fam98c Ngp AABR07056633.1 Mast4 Kctd18 Tmie Nbeal2 Arhgef18 Pex11g Kansl1l Mcemp1 Unc80 Lrrc8e Zfp84 Plxnb1 Slc8a3 Insr Dhx16 Lrrc2 Zfp14 AC107280.1 ENSRNOG00000031607 Nckipsd Impdh2 Uqcrc1 Mtus2 RT1-T24-1 Plcl1 Srek1 Dclk3 Plcb4 Cep170b Rasgrp4 Mlh1 Als2cl Aox2 Mir331 Cisd3 Rtp3 Prss50 Zfp420 Psmd8 Plekhd1 Cenpk Mrpl42 RT1-T24-4 Epm2aip1 ENSRNOG00000046155 Pnpo Zfp84 Phb Erbin Tma7 Srek1ip1 Zfp566 Cdk5rap3 Prr15l Pomp Syne4 Cox7a1 Clip3 Pet100 AABR07044375.1 Spred3 Psmb3 Celsr3 Boll Fgd6 ENSRNOG00000054635 Yif1b AABR07002868.1 Ddr1 Ube2n N4bp2l1 Catsperg Dnah7 RT1-T18 ENSRNOG00000062698 ENSRNOG00000063935 ENSRNOG00000064807 ENSRNOG00000064815 ENSRNOG00000064836 ENSRNOG00000065023 ENSRNOG00000065195 ENSRNOG00000065339 Zfp958 ENSRNOG00000065623 Shld3 Capns1 ENSRNOG00000067131 B4galnt2 ENSRNOG00000068276 ENSRNOG00000068541 ENSRNOG00000068850 Atp5mc1 ENSRNOG00000069389 Zfp74 ENSRNOG00000069592 ENSRNOG00000069961 ENSRNOG00000070140 Tedc1 Zfp27
Length without tail	11.69	64	29	50	0.98	3.72e-177	Zfp958l1 Fry Rxfp2 Hsph1 Wdr95 Slc7a1 Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Retn Trappc5 Evi5l Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Elk3 Lta4h Amdhd1 Snrpf Ntn4 Vezt Ndufa12 Plxnc1 Cradd Socs2 Trim23 Shisal2b Rgs7bp Il6st Map4 Scn1b Gramd1a Metap2 Trex1 Arhgef18 Mcemp1 Lrrc8e Insr Dclk3 Mir331 Pnpla8 Srek1ip1 Katnal1 Pet100 Fgd6 Dmkn N4bp2l1 B3glct ENSRNOG00000063599 ENSRNOG00000065248 Zfp958 ENSRNOG00000065898 Capns1 ENSRNOG00000067247 ENSRNOG00000068541 ENSRNOG00000069365
Liver weight, right	11.06	1	0	0	0	1.00e+00	Rxfp2
Extensor digitorum longus weight	7.78	62	38	65.5	0.91	1.56e-134	Zfp958l1 Fry Rxfp2 Mcoln1 Camsap3 Xab2 Pcp2 Stxbp2 Trappc5 Evi5l Map2k7 Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Cwc25 Crip2 Tmem121 Mrpl45 Srcin1 Zfyve21 Pip4k2b ENSRNOG00000013097 Tmem179 Cwc27 Rgs7bp Clba1 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Npepps Crip1 Arhgef18 Tex22 Mcemp1 Lrrc8e Pld4 Akt1 Siva1 Inf2 Insr Cep170b Cisd3 Srek1ip1 Pet100 Psmb3 N4bp2l1 ENSRNOG00000065195 Zfp958 ENSRNOG00000067921 ENSRNOG00000068541 ENSRNOG00000068850 Tedc1
Soleus weight	7.52	1	0	0	0	1.00e+00	Ca8
Tibialis anterior weight	7.3	33	19	32.8	0.99	5.96e-166	Zfp958l1 Fry Rxfp2 Mcoln1 Pnpla6 Camsap3 Xab2 Pcp2 Stxbp2 Retn Trappc5 Evi5l Map2k7 Snapc2 Timm44 Elavl1 Cers4 Stard13 Kl Pds5b N4bp2l2 Brca2 Arhgef18 Pex11g Mcemp1 Lrrc8e Insr Pnpla8 Pet100 N4bp2l1 Zfp958 ENSRNOG00000068541 ENSRNOG00000068850
Tibia length	7.71	94	22	37.9	0.99	0.00e+00	Mcoln1 Stxbp2 Trappc5 Evi5l Snapc2 Pds5b N4bp2l2 Brca2 Nedd1 Cdk17 Elk3 Lta4h Hal Amdhd1 Snrpf Ntn4 Vezt Nr2c1 Ndufa12 Tmcc3 Cep83 Plxnc1 Cradd Socs2 Nln Sgtb Trappc13 Trim23 Stk17b Adamts6 Hecw2 Pgap1 Rgs7bp Sf3b1 Coq10b Hspd1 Prkar2a Slc26a6 Pfkfb4 Shisa5 Atrip Ccdc51 Nme6 Camp Cdc25a Map4 Smarcc1 Cspg5 Elp6 Scap Ptpn23 Klhl18 Kif9 Setd2 Ccdc12 Pth1r Myl3 Lrrfip2 Trank1 Metap2 Ccdc38 Trex1 Ngp AABR07056633.1 Mast4 Tmie Nbeal2 Plxnb1 Insr Lrrc2 AC107280.1 Nckipsd Impdh2 Srek1 Dclk3 Mlh1 Als2cl Mir331 Rtp3 Prss50 Cenpk Epm2aip1 ENSRNOG00000046155 Erbin Tma7 Pet100 Celsr3 Fgd6 Usp4 ENSRNOG00000062698 ENSRNOG00000064815 ENSRNOG00000065339 Shld3 ENSRNOG00000070140
Delay discounting time to switch 0 sec	12.85	20	0	0	-1	5.14e-208	Crip2 Tmem121 ENSRNOG00000013097 Tmem179 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Tex22 Pld4 Akt1 Siva1 Inf2 Cep170b ENSRNOG00000065195 ENSRNOG00000067921 Tedc1
Delay discounting water rate 0 sec	17.6	23	21	36.2	1	1.29e-219	Crip2 Tmem121 Zfyve21 ENSRNOG00000013097 Tmem179 Clba1 Cdca4 Gpr132 Jag2 Nudt14 Brf1 Btbd6 Pacs2 Crip1 Tex22 Pld4 Akt1 Siva1 Inf2 Cep170b ENSRNOG00000065195 ENSRNOG00000067921 Tedc1
Delay discounting water rate 12 sec	13.62	1	0	0	0	1.00e+00	Zfyve21
Delay discounting water rate 6 sec	13.54	15	0	0	1	6.41e-199	Nln Sgtb Trappc13 Trim23 Adamts6 Cwc27 Shisal2b Rgs7bp Mast4 Srek1 Cenpk Erbin Srek1ip1 ENSRNOG00000062698 Shld3
Locomotor activity	14.39	1	0	0	0	1.00e+00	Pnpla8
Locomotor testing distance	12.45	1	0	0	0	1.00e+00	Pnpla8
Light reinforcement 1	9.98	1	0	0	0	1.00e+00	Kctd18
Reaction time num false alarms	22.57	1	1	1.7	0	1.00e+00	Slx4
Reaction time num false alarms AUC	20.34	1	1	1.7	0	1.00e+00	Slx4
Reaction time premature initiations	12.92	5	0	0	1	8.31e-16	Trappc13 Cwc27 Shisal2b Rgs7bp Srek1ip1
One hour access (shock baseline)	15.37	1	0	0	0	1.00e+00	Cradd
Bone: apparent density	11.98	7	0	0	0.99	1.33e-29	Zfp958l1 Fry Rxfp2 ENSRNOG00000065248 Zfp958 ENSRNOG00000065898 ENSRNOG00000068541
Bone surface	11.55	11	1	1.7	0.99	1.61e-28	Zfp958l1 Fry Rxfp2 Snapc2 Elavl1 Cers4 Il6st ENSRNOG00000065248 Zfp958 ENSRNOG00000065898 ENSRNOG00000068541
Bone volume	11.84	8	0	0	1	1.67e-26	Zfp958l1 Fry Rxfp2 Il6st ENSRNOG00000065248 Zfp958 ENSRNOG00000065898 ENSRNOG00000068541
Bone: connectivity density	12.35	10	0	0	0.99	1.46e-30	Zfp958l1 Fry Rxfp2 Snapc2 Elavl1 Lrrc8e Pet100 ENSRNOG00000065248 Zfp958 ENSRNOG00000068541
Bone: cortical area	13.04	1	0	0	0	1.00e+00	Il6st
Bone: endosteal estimation	8.29	5	0	0	1	1.71e-09	RT1-S3 RT1-N3 RT1-T24-1 RT1-T24-4 ENSRNOG00000064836
Bone: final moment	11.37	1	0	0	0	1.00e+00	Il6st
Bone: maximum force	11.23	1	0	0	0	1.00e+00	Il6st
Bone: maximum moment	11.42	1	0	0	0	1.00e+00	Il6st
Bone: periosteal estimation	10.76	1	0	0	0	1.00e+00	Il6st
Fe content in liver	15.06	1	0	0	0	1.00e+00	B3glct
Se content in liver	15.08	2	0	0	0	1.00e+00	Rpp30 Htr7

Associations by panel

Tissue	RNA modality	# hits	% hits/tests	Avg chisq
Adipose	alternative polyA	29	1.4	3.87
Adipose	alternative TSS	20	1.2	3.62
Adipose	gene expression	112	1.3	3.53
Adipose	isoform ratio	29	1	3.47
Adipose	intron excision ratio	22	0.8	3.53
Adipose	mRNA stability	46	1.3	3.58
BLA	alternative polyA	10	0.8	3.65
BLA	alternative TSS	9	1.1	3.55
BLA	gene expression	105	1.7	3.7
BLA	isoform ratio	25	1.4	3.97
BLA	intron excision ratio	35	1.2	3.81
BLA	mRNA stability	37	1.8	3.79
Brain	alternative polyA	23	1.1	3.65
Brain	alternative TSS	28	1.6	3.84
Brain	gene expression	126	1.4	3.54
Brain	isoform ratio	30	0.9	3.6
Brain	intron excision ratio	72	1.3	3.86
Brain	mRNA stability	56	1.3	3.47
Eye	alternative polyA	2	1.1	3.27
Eye	alternative TSS	9	3.8	3.87
Eye	gene expression	19	1.7	3.61
Eye	isoform ratio	1	0.3	3.91
Eye	intron excision ratio	10	1.6	4.11
Eye	mRNA stability	6	2.6	3.89
IL	alternative polyA	13	2.1	4.21
IL	alternative TSS	8	2.8	4.18
IL	gene expression	48	1.3	3.57
IL	isoform ratio	12	1.5	4.61
IL	intron excision ratio	8	0.8	3.55
IL	mRNA stability	21	1.9	3.67
LHb	alternative polyA	11	1.9	4.29
LHb	alternative TSS	1	0.3	3.22
LHb	gene expression	45	1.4	3.5
LHb	isoform ratio	11	1.5	4.04
LHb	intron excision ratio	13	1.3	3.79
LHb	mRNA stability	20	1.9	3.74
Liver	alternative polyA	11	0.7	3.61
Liver	alternative TSS	14	0.9	3.33
Liver	gene expression	101	1.4	3.5
Liver	isoform ratio	26	1.1	3.45
Liver	intron excision ratio	44	1	3.53
Liver	mRNA stability	42	1.7	3.61
NAcc	alternative polyA	20	1.5	3.79
NAcc	alternative TSS	15	1.6	3.89
NAcc	gene expression	107	1.7	3.77
NAcc	isoform ratio	24	1.3	3.93
NAcc	intron excision ratio	40	1.3	3.87
NAcc	mRNA stability	43	1.9	3.74
OFC	alternative polyA	6	1	3.56
OFC	alternative TSS	5	1.6	3.48
OFC	gene expression	57	1.5	3.61
OFC	isoform ratio	13	1.6	4.12
OFC	intron excision ratio	12	1.2	4.04
OFC	mRNA stability	20	1.9	3.71
PL	alternative polyA	17	1.2	3.66
PL	alternative TSS	19	1.6	4.1
PL	gene expression	114	1.5	3.61
PL	isoform ratio	35	1.6	4.02
PL	intron excision ratio	61	1.7	4.04
PL	mRNA stability	55	1.9	3.65