Hub : Genes

Tnfrsf10b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Tnfrsf10b 0.42 0.25 5.4e-07 0.19 0.18 0.18 0.18 2.5e-05 5.3e-05 4.0e-05 3.6e-05
2 Adipose gene expression Tnfrsf10b 0.16 0.13 5.6e-17 0.14 0.14 0.14 0.15 8.6e-16 1.4e-15 1.1e-15 6.8e-16
3 OFC gene expression Tnfrsf10b 0.29 0.22 5.4e-04 0.09 0.08 0.09 0.08 4.8e-03 5.7e-03 4.3e-03 5.4e-03
4 Liver gene expression Tnfrsf10b 0.11 0.12 1.0e-09 0.08 0.08 0.08 0.08 2.7e-09 4.6e-09 2.1e-09 3.6e-09
5 Brain alternative TSS XM_063274494.1 0.03 0.03 4.8e-03 0.02 0.02 0.02 0.02 3.3e-03 3.3e-03 3.3e-03 4.1e-03
6 Eye gene expression Tnfrsf10b 0.31 0.23 2.2e-03 0.15 0.16 0.14 0.15 2.5e-03 2.0e-03 4.0e-03 2.6e-03
7 Brain gene expression Tnfrsf10b 0.16 0.14 1.7e-12 0.13 0.14 0.13 0.13 6.2e-12 1.3e-12 3.5e-12 5.8e-12
8 pVTA alternative TSS NM_001395720.1 0.09 0.08 1.1e-05 0.06 0.06 0.06 0.06 6.5e-06 7.9e-06 7.0e-06 7.7e-06
9 pVTA alternative TSS XM_063274494.1 0.07 0.07 5.0e-05 0.06 0.06 0.06 0.06 2.7e-05 3.3e-05 3.1e-05 3.1e-05
10 PL gene expression Tnfrsf10b 0.06 0.06 1.0e-05 0.04 0.04 0.04 0.04 1.9e-05 1.8e-05 1.2e-05 1.8e-05
11 pVTA gene expression Tnfrsf10b 0.3 0.21 0.0e+00 0.23 0.24 0.24 0.24 7.4e-19 2.6e-19 2.4e-19 3.5e-19
12 NAcc alternative TSS XM_063274494.1 0.02 0.02 9.0e-03 0.01 0.01 0.01 0.01 6.0e-03 7.3e-03 4.1e-02 1.1e-02
13 NAcc gene expression Tnfrsf10b 0.1 0.09 1.1e-11 0.07 0.07 0.07 0.07 6.4e-11 7.7e-11 9.0e-11 7.6e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.22.12.41.5-1.51.5-1.5-1.6-1.5-1.51.4-1.41.41.4-1.41.4
Area under the delay curve0.10.10.1-0.30.3-0.40.40.40.30.3-0.20.2-0.3-0.20.3-0.3
BMI with tail0.41.51.9-1.41.4-1.21.11.21.21.2-1.21.2-1.2-1.21.2-1.2
BMI without tail0.00.00.0-0.20.2-0.10.00.0-0.0-0.00.1-0.10.00.1-0.10.1
Body weight0.62.83.2-1.81.8-1.61.61.61.71.7-1.61.6-1.7-1.61.8-1.8
Weight adjusted by age0.82.22.4-1.51.5-1.51.51.51.51.5-1.51.5-1.5-1.51.5-1.5
Bone surface0.61.11.21.1-1.11.1-1.1-1.1-1.0-1.01.0-1.01.01.0-1.01.0
Bone volume0.61.21.31.1-1.11.1-1.2-1.2-1.1-1.11.1-1.11.11.1-1.11.1
Breakpoint value in progressive ratio session0.10.10.3-0.50.5-0.40.20.40.30.3-0.30.3-0.4-0.30.3-0.3
Number of licking bursts0.00.00.0-0.20.2-0.10.10.00.00.00.1-0.1-0.00.1-0.00.0
Context. condit. distance diff. score0.81.01.10.8-0.81.0-1.0-1.0-1.0-1.01.1-1.11.11.1-1.11.1
Locomotion velocity, session 10.20.20.3-0.40.4-0.40.50.50.50.5-0.50.5-0.5-0.50.4-0.4
Locomotion distance, session 10.00.00.00.0-0.00.00.0-0.0-0.1-0.10.2-0.20.10.2-0.20.2
Locomotion velocity, session 20.00.00.20.4-0.40.3-0.2-0.2-0.2-0.10.1-0.10.10.1-0.20.2
Locomotion distance, session 20.00.00.10.3-0.30.2-0.1-0.2-0.1-0.10.1-0.10.10.1-0.10.1
Locomotion velocity, session 30.50.60.7-0.80.8-0.80.90.80.80.8-0.70.7-0.8-0.70.7-0.7
Locomotion distance, session 30.00.00.00.1-0.10.1-0.1-0.1-0.2-0.20.2-0.20.20.2-0.20.2
Stereotopy head waving bouts, day 30.70.81.0-0.80.8-1.01.01.00.90.9-0.90.9-0.9-0.90.9-0.9
Stereotopy head waving duration, day 32.43.03.1-1.71.7-1.81.81.81.71.7-1.71.7-1.7-1.71.7-1.7
Locomotion velocity, session 73.94.34.61.9-1.92.1-2.1-2.1-2.1-2.12.1-2.12.12.1-2.12.1
Locomotion distance, session 73.14.04.32.0-2.02.0-2.0-2.1-2.0-2.02.0-2.02.02.0-2.02.0
Stereotopy head waving bouts, day 71.41.61.9-1.11.1-1.21.21.21.31.3-1.41.4-1.3-1.41.4-1.4
Stereotopy head waving duration, day 72.02.42.6-1.51.5-1.51.51.51.61.6-1.61.6-1.6-1.61.6-1.6
Locomotion velocity, session 80.00.00.10.2-0.20.10.0-0.0-0.0-0.0-0.00.00.0-0.0-0.00.0
Locomotion distance, session 80.60.90.90.9-0.90.9-0.9-0.9-0.9-0.90.9-0.90.90.9-1.01.0
Degree of sensitization distance4.24.54.92.1-2.12.2-2.2-2.2-2.1-2.12.1-2.12.12.1-2.12.1
Degree of sensitization stereotypy1.01.11.3-0.90.9-1.01.01.01.11.1-1.11.1-1.1-1.11.1-1.1
Conditioned locomotion0.00.00.10.1-0.10.2-0.2-0.2-0.2-0.20.2-0.20.20.2-0.20.2
Cocaine response after cond. corrected0.20.30.4-0.60.6-0.60.50.60.60.6-0.60.6-0.5-0.60.5-0.5
Cocaine response after cond. not corrected0.10.20.3-0.40.4-0.50.40.50.40.4-0.40.4-0.4-0.40.4-0.4
Cocaine response before conditioning0.20.20.40.6-0.60.5-0.4-0.4-0.4-0.40.4-0.40.40.4-0.40.4
Saline control response0.10.10.20.4-0.40.4-0.4-0.4-0.4-0.40.3-0.30.40.3-0.40.4
Bone: connectivity density2.43.94.21.9-1.92.0-2.1-2.1-2.0-2.01.9-1.92.01.9-1.91.9
Bone: cortical apparent density0.00.10.10.1-0.10.2-0.3-0.3-0.3-0.30.3-0.30.30.3-0.30.3
Bone: cortical area0.00.00.00.0-0.00.0-0.1-0.1-0.0-0.0-0.00.00.0-0.00.0-0.0
Bone: cortical porosity1.11.21.3-1.01.0-1.11.11.11.11.1-1.11.1-1.1-1.11.1-1.1
Bone: cortical porosity0.60.70.7-0.70.7-0.80.90.90.90.9-0.90.9-0.9-0.90.9-0.9
Bone: cortical thickness0.00.00.00.1-0.10.0-0.0-0.0-0.0-0.00.0-0.00.00.0-0.00.0
Bone: cortical thickness0.00.00.00.1-0.10.0-0.0-0.0-0.0-0.00.0-0.00.00.0-0.00.0
Bone: cortical tissue density0.10.10.10.2-0.20.3-0.3-0.3-0.3-0.30.3-0.30.30.3-0.30.3
Condit. Reinf. active minus inactive responses0.60.70.9-0.90.9-0.90.90.90.80.8-0.70.7-0.7-0.70.7-0.7
Condit. Reinf. active-inactive response ratio2.52.73.1-1.71.7-1.71.81.71.61.6-1.61.6-1.5-1.61.5-1.5
Condit. Reinf. active responses0.00.00.0-0.10.1-0.10.20.10.10.1-0.00.0-0.0-0.00.0-0.0
Condit. Reinf. inactive responses2.43.13.31.8-1.81.8-1.8-1.8-1.7-1.71.7-1.71.71.7-1.71.7
Incentive salience index mean0.81.11.4-1.21.2-1.11.11.11.01.0-1.01.0-1.0-1.00.9-0.9
Condit. Reinf. lever presses0.30.50.7-0.90.9-0.80.80.70.70.7-0.70.7-0.6-0.70.6-0.6
Condit. Reinf. active minus inactive responses0.30.50.60.8-0.80.7-0.6-0.6-0.7-0.70.7-0.70.70.7-0.70.7
Condit. Reinf. active-inactive response ratio0.00.10.1-0.30.3-0.30.30.30.30.3-0.20.2-0.3-0.20.2-0.2
Condit. Reinf. active responses0.91.31.71.3-1.31.2-1.1-1.1-1.1-1.11.1-1.11.11.1-1.11.1
Condit. Reinf. inactive responses1.82.63.01.7-1.71.7-1.6-1.6-1.6-1.61.6-1.61.61.6-1.61.6
Condit. Reinf. lever presses0.10.20.20.5-0.50.5-0.4-0.5-0.4-0.40.5-0.50.40.5-0.40.4
Condit. Reinf. lever reinforcers received0.71.01.31.1-1.11.0-1.0-1.0-1.0-1.01.0-1.01.01.0-1.01.0
Conditioned reinforcement - actives0.41.71.71.2-1.21.3-1.3-1.3-1.3-1.31.3-1.31.31.3-1.31.3
Conditioned reinforcement - inactives1.64.54.72.0-2.02.1-2.2-2.1-2.1-2.12.1-2.12.12.1-2.12.1
Conditioned locomotion0.10.20.20.5-0.50.4-0.4-0.4-0.4-0.40.4-0.40.40.4-0.40.4
Patch foraging indifference point 0 sec1.23.34.02.0-2.01.8-1.9-1.8-1.8-1.81.7-1.71.81.7-1.71.7
Patch foraging indifference point AUC0.10.30.5-0.70.7-0.70.70.70.60.6-0.50.5-0.5-0.50.5-0.5
Delay disc. indifference point, 0s delay0.30.30.50.5-0.50.5-0.5-0.5-0.6-0.60.6-0.60.70.6-0.70.7
Delay disc. indifference point, 16s delay0.20.20.30.4-0.40.4-0.4-0.4-0.5-0.50.5-0.50.50.5-0.40.4
Delay disc. indifference point, 2s delay1.51.61.7-1.31.3-1.31.31.31.31.3-1.31.3-1.3-1.31.3-1.3
Delay disc. indifference point, 24s delay0.10.20.3-0.50.5-0.50.50.50.40.4-0.40.4-0.5-0.40.5-0.5
Delay disc. indifference point, 4s delay1.81.92.1-1.41.4-1.41.51.41.41.4-1.31.3-1.3-1.31.3-1.3
Delay disc. indifference point, 8s delay0.00.00.00.1-0.10.1-0.1-0.1-0.2-0.20.2-0.20.20.2-0.20.2
Indifference point function ln k0.00.00.00.1-0.10.1-0.2-0.1-0.1-0.1-0.00.00.1-0.0-0.00.0
Indifference point function log k0.00.00.00.1-0.10.1-0.2-0.1-0.1-0.1-0.00.00.1-0.0-0.00.0
Patch foraging total patch changes 0 sec0.82.43.01.7-1.71.6-1.6-1.6-1.5-1.51.5-1.51.51.5-1.41.4
Patch foraging total patch changes 12 sec0.60.81.01.0-1.00.8-0.9-0.8-0.9-0.90.9-0.90.90.9-0.90.9
Patch foraging total patch changes 18 sec0.92.02.41.5-1.51.3-1.3-1.3-1.4-1.41.5-1.51.41.5-1.41.4
Patch foraging total patch changes 24 sec0.00.00.0-0.20.2-0.20.10.20.00.00.0-0.0-0.10.00.0-0.0
Patch foraging total patch changes 6 sec0.20.30.40.6-0.60.5-0.6-0.5-0.6-0.60.6-0.60.60.6-0.60.6
Patch foraging time to switch 0 sec0.31.01.10.9-0.91.0-1.0-1.0-1.0-1.01.0-1.01.01.0-1.01.0
Patch foraging water rate 0 sec0.10.50.6-0.60.6-0.60.60.60.70.7-0.70.7-0.7-0.70.8-0.8
Patch foraging water rate 12 sec0.21.01.1-1.01.0-0.90.90.91.01.0-1.01.0-1.0-1.01.0-1.0
Patch foraging water rate 18 sec1.73.94.4-1.81.8-1.81.81.92.02.0-2.12.1-2.0-2.12.1-2.1
Patch foraging water rate 24 sec0.10.20.3-0.20.2-0.20.20.20.40.4-0.50.5-0.4-0.50.5-0.5
Patch foraging water rate 6 sec1.92.93.2-1.81.8-1.71.71.61.71.7-1.71.7-1.7-1.71.7-1.7
Seeking ratio, delayed vs. immediate footshock0.91.31.61.2-1.21.2-1.2-1.2-1.1-1.11.0-1.01.11.0-1.01.0
Distance traveled before self-admin0.51.01.1-1.01.0-1.01.01.01.01.0-1.01.0-1.0-1.01.0-1.0
Distance traveled after self-admin1.73.03.3-1.51.5-1.71.81.71.81.8-1.81.8-1.8-1.81.8-1.8
Extensor digitorum longus weight13.152.256.2-7.57.5-7.37.27.37.27.2-7.17.1-7.1-7.17.1-7.1
Bone: elastic displacement0.40.50.50.7-0.70.6-0.6-0.6-0.7-0.70.7-0.70.70.7-0.70.7
Bone: elastic work0.20.20.30.5-0.50.5-0.5-0.5-0.5-0.50.5-0.50.50.5-0.50.5
Bone: endosteal estimation0.00.10.1-0.30.3-0.30.30.30.30.3-0.40.4-0.3-0.40.4-0.4
Bone: endosteal perimeter0.00.10.1-0.20.2-0.20.20.20.20.2-0.30.3-0.2-0.30.3-0.3
Epididymis fat weight0.52.52.61.5-1.51.6-1.6-1.6-1.6-1.61.6-1.61.61.6-1.61.6
Delta time in closed arm before/after self-admin4.23.94.22.0-2.01.9-1.9-1.9-1.9-2.02.0-2.02.02.0-2.02.0
Delta time in open arm before/after self-admin0.10.10.1-0.20.2-0.10.10.20.20.2-0.30.3-0.4-0.30.3-0.3
Diff in mean of infusions in LGA sessions0.81.42.2-1.51.5-1.31.11.21.11.1-1.11.1-1.1-1.11.1-1.1
Delay discount exponential model param0.30.50.60.7-0.70.7-0.7-0.7-0.7-0.70.6-0.60.70.6-0.60.6
Extinction: sum of active levers before priming1.52.32.41.4-1.41.5-1.5-1.6-1.5-1.51.5-1.51.51.5-1.51.5
Active lever presses in extinction session 60.50.50.70.4-0.40.4-0.6-0.4-0.7-0.70.8-0.80.80.8-0.80.8
Bone: final force0.10.20.3-0.60.6-0.50.40.40.40.4-0.40.4-0.4-0.40.4-0.4
Bone: final moment0.10.10.2-0.50.5-0.40.30.30.30.3-0.40.4-0.3-0.40.4-0.4
Food consumed during 24 hour testing period0.20.30.30.6-0.60.5-0.5-0.5-0.6-0.60.6-0.60.60.6-0.60.6
Glucose0.00.00.1-0.30.3-0.10.00.10.00.00.0-0.00.00.0-0.00.0
Heart weight0.40.60.80.7-0.70.8-0.9-0.9-0.8-0.80.7-0.70.80.7-0.80.8
Delay discount hyperbolic model param0.40.60.70.8-0.80.8-0.8-0.8-0.7-0.70.7-0.70.70.7-0.70.7
Intermittent access intake day 1-15 change0.73.64.42.1-2.11.9-1.9-1.9-1.9-1.91.9-1.91.91.9-1.91.9
Intermittent access intake escalation0.73.84.52.1-2.12.0-1.9-1.9-1.9-1.91.9-1.91.91.9-1.91.9
Intermittent access intake escalation 21.01.72.41.5-1.51.3-1.3-1.3-1.3-1.31.3-1.31.31.3-1.31.3
Intermitt. access day 1 inactive lever presses0.00.00.00.1-0.10.1-0.1-0.1-0.1-0.10.1-0.10.10.1-0.10.1
Intermitt. access day 15 inactive lever presses0.00.00.10.0-0.00.2-0.2-0.2-0.2-0.20.2-0.20.20.2-0.20.2
Intermitt. access escalation Index0.00.10.2-0.40.4-0.30.30.20.20.2-0.20.2-0.2-0.20.2-0.2
Intermittent access day 1 total infusions0.00.00.0-0.10.1-0.10.00.00.00.0-0.00.0-0.0-0.00.0-0.0
Intermittent access day 15 total infusions1.02.52.71.6-1.61.6-1.6-1.6-1.6-1.61.6-1.61.61.6-1.61.6
Intermittent access terminal intake (last 3 days)0.81.41.71.3-1.31.2-1.2-1.2-1.2-1.21.2-1.21.21.2-1.21.2
Intermittent access total infusions1.21.41.41.2-1.21.2-1.2-1.2-1.2-1.21.2-1.21.21.2-1.21.2
Intermittent access day 1 locomotion0.00.00.00.1-0.10.1-0.1-0.1-0.1-0.10.1-0.10.10.1-0.10.1
Intermittent access day 15 total locomotion0.10.40.70.8-0.80.7-0.6-0.6-0.6-0.60.6-0.60.60.6-0.60.6
Intermittent access total locomotion0.10.10.20.4-0.40.3-0.3-0.3-0.3-0.30.3-0.30.30.3-0.30.3
Intermittent access standard deviation0.10.30.60.8-0.80.6-0.5-0.5-0.5-0.50.5-0.50.50.5-0.50.5
Left kidney weight0.00.20.2-0.40.4-0.30.30.30.40.4-0.40.4-0.4-0.40.5-0.5
Right kidney weight0.00.10.1-0.20.2-0.20.10.10.20.2-0.20.2-0.3-0.20.3-0.3
Cocaine induced anxiety0.00.00.0-0.20.2-0.10.10.10.10.1-0.00.0-0.1-0.00.0-0.0
Post-drug Anxiety0.80.91.00.9-0.90.9-0.9-0.9-1.0-1.01.0-1.01.01.0-1.01.0
Baseline Anxiety0.30.50.60.7-0.70.7-0.6-0.6-0.7-0.70.7-0.70.70.7-0.70.7
Tail length0.41.92.11.3-1.31.4-1.3-1.4-1.4-1.41.4-1.41.41.4-1.41.4
Length with tail0.00.20.2-0.40.4-0.40.40.40.40.4-0.40.4-0.4-0.40.5-0.5
Length without tail1.47.27.6-2.72.7-2.72.62.62.72.7-2.72.7-2.7-2.72.7-2.7
Times rat made contact with spout0.50.60.70.8-0.80.7-0.7-0.7-0.8-0.80.8-0.80.70.8-0.80.8
Lifetime Intake0.60.80.80.9-0.90.9-0.9-0.9-0.9-0.90.9-0.90.90.9-0.90.9
Liver weight, left1.83.13.3-1.81.8-1.81.81.81.71.7-1.71.7-1.7-1.71.7-1.7
Liver weight, right0.50.80.9-0.90.9-0.90.90.90.90.9-0.90.9-0.9-0.90.9-0.9
Locomotor activity1.52.42.6-1.41.4-1.51.51.61.61.6-1.61.6-1.6-1.61.6-1.6
Locomotor testing distance0.00.10.20.4-0.40.3-0.2-0.2-0.2-0.20.2-0.20.20.2-0.20.2
Locomotor testing rearing0.10.30.60.8-0.80.6-0.5-0.5-0.5-0.50.5-0.50.50.5-0.50.5
Locomotion in novel chamber0.40.60.70.8-0.80.8-0.8-0.8-0.8-0.80.7-0.70.80.7-0.80.8
Locomotion in novel chamber post-restriction0.41.11.2-0.90.9-0.90.90.91.01.0-1.11.1-1.0-1.11.1-1.1
Fecal boli incidents, locomotor time 10.61.51.6-1.21.2-1.21.31.31.21.2-1.21.2-1.3-1.21.2-1.2
Change in fecal boli incidents, locomotor task0.30.30.4-0.60.6-0.50.50.50.50.5-0.50.5-0.5-0.50.5-0.5
Time >=10cm from walls, locomotor time 10.80.91.10.8-0.80.9-0.9-0.9-1.0-1.01.1-1.11.01.0-1.01.0
Bouts of movement, locomotor time 14.25.45.8-2.42.4-2.42.42.42.32.3-2.32.3-2.2-2.32.1-2.1
Total resting periods, locomotor time 14.55.25.6-2.42.4-2.42.42.42.32.3-2.32.3-2.2-2.22.1-2.1
Rest time, locomotor task time 11.52.42.8-1.71.7-1.61.61.61.51.5-1.51.5-1.5-1.51.4-1.4
Distance moved, locomotor task time 11.23.43.82.0-2.01.9-1.8-1.8-1.8-1.81.9-1.91.81.9-1.71.7
Vertical activity count, locomotor time 10.21.21.31.2-1.21.1-1.1-1.1-1.1-1.11.1-1.11.11.1-1.01.0
Time >=10cm from walls, locomotor time 20.20.40.5-0.70.7-0.70.60.60.70.7-0.70.7-0.6-0.70.6-0.6
Bouts of movement, locomotor time 21.55.15.4-2.22.2-2.32.32.32.32.3-2.32.3-2.2-2.32.2-2.2
Total resting periods, locomotor time 21.45.55.7-2.32.3-2.32.42.32.42.4-2.42.4-2.3-2.32.3-2.3
Rest time, locomotor task time 20.61.11.3-1.21.2-1.01.01.01.01.0-1.11.1-1.0-1.01.0-1.0
Distance moved, locomotor task time 22.73.64.02.0-2.01.9-1.9-1.9-1.9-1.91.9-1.91.91.9-1.81.8
Vertical activity count, locomotor time 20.20.50.60.7-0.70.7-0.7-0.7-0.7-0.70.8-0.80.70.7-0.70.7
Light reinforcement 11.25.35.82.4-2.42.4-2.4-2.4-2.3-2.32.3-2.32.22.3-2.22.2
Light reinforcement 20.51.11.40.8-0.81.1-1.1-1.1-1.1-1.11.2-1.21.11.2-1.11.1
Bone: marrow area0.00.00.1-0.20.2-0.20.10.10.20.2-0.20.2-0.2-0.20.2-0.2
Bone: maximum diameter0.30.60.7-0.70.7-0.70.70.70.80.8-0.80.8-0.8-0.80.8-0.8
Bone: maximum force0.30.50.5-0.70.7-0.70.70.70.70.7-0.70.7-0.7-0.70.7-0.7
Bone: maximum moment0.20.30.3-0.50.5-0.50.50.50.60.6-0.60.6-0.6-0.60.6-0.6
Mean time between licks in bursts0.42.52.71.4-1.41.6-1.6-1.6-1.6-1.61.7-1.71.61.7-1.61.6
Mean num. licks in bursts0.10.40.60.8-0.80.6-0.6-0.6-0.6-0.60.5-0.50.60.5-0.60.6
Cd content in liver1.21.31.5-1.21.2-1.21.21.21.11.1-1.11.1-1.1-1.11.1-1.1
Co content in liver5.15.96.3-2.52.5-2.52.52.52.42.4-2.42.4-2.4-2.42.4-2.4
Cu content in liver0.40.50.7-0.80.8-0.80.70.80.70.7-0.70.7-0.7-0.70.6-0.6
Fe content in liver1.62.02.21.5-1.51.5-1.4-1.4-1.4-1.41.4-1.41.41.4-1.41.4
K content in liver1.11.11.21.1-1.11.0-1.1-1.0-1.1-1.11.1-1.11.11.1-1.11.1
Mg content in liver2.62.83.31.8-1.81.7-1.7-1.7-1.7-1.71.7-1.71.71.7-1.71.7
Mn content in liver2.62.93.41.8-1.81.7-1.7-1.7-1.7-1.71.7-1.71.71.7-1.71.7
Na content in liver0.91.01.1-0.90.9-1.01.01.01.01.0-1.01.0-1.0-1.01.0-1.0
Rb content in liver0.00.00.10.3-0.30.2-0.2-0.2-0.2-0.20.1-0.10.20.1-0.20.2
Se content in liver1.01.11.21.1-1.11.1-1.1-1.0-1.1-1.11.0-1.01.11.0-1.11.1
Sr content in liver0.00.00.00.1-0.10.1-0.1-0.0-0.1-0.10.2-0.20.10.2-0.20.2
Zn content in liver0.10.10.20.2-0.20.3-0.3-0.3-0.4-0.40.4-0.40.40.4-0.40.4
Bone: minimum diameter0.10.20.3-0.50.5-0.50.40.40.50.5-0.50.5-0.5-0.50.5-0.5
Time in familiar zone, hab. session 10.00.00.0-0.10.1-0.10.10.10.20.2-0.20.2-0.2-0.20.2-0.2
Time in novel zone, hab. session 11.11.21.4-1.11.1-1.21.11.21.11.1-1.11.1-1.1-1.11.1-1.1
Total zone transitions, hab. session 10.20.30.4-0.50.5-0.60.60.60.50.5-0.50.5-0.5-0.50.5-0.5
Total locomotion distance, hab. session 10.00.00.00.1-0.1-0.00.10.0-0.0-0.00.1-0.10.00.1-0.10.1
Locomotion velocity, hab. session 10.10.10.20.4-0.40.3-0.2-0.3-0.3-0.30.4-0.40.30.4-0.40.4
Time in familiar zone, hab. session 21.92.22.3-1.51.5-1.41.51.41.51.5-1.51.5-1.5-1.51.5-1.5
Time in novel zone, hab. session 20.70.80.90.9-0.90.9-0.9-0.8-0.9-0.90.9-0.90.90.9-0.90.9
Total zone transitions, hab. session 21.41.82.0-1.41.4-1.41.41.41.31.3-1.31.3-1.3-1.31.3-1.3
Total locomotion distance, hab. session 20.20.30.4-0.60.6-0.60.60.60.60.6-0.50.5-0.5-0.50.5-0.5
Locomotion velocity, hab. session 20.60.80.9-0.90.9-0.90.90.90.90.9-0.80.8-0.9-0.80.8-0.8
Novel to familiar place preference ratio1.31.71.71.3-1.31.3-1.3-1.3-1.3-1.31.3-1.31.31.3-1.31.3
Novelty place preference1.01.31.41.2-1.21.1-1.2-1.1-1.2-1.21.2-1.21.21.2-1.11.1
Time in novel zone, NPP test0.60.70.70.8-0.80.8-0.8-0.8-0.8-0.80.9-0.90.80.9-0.80.8
Total zone transitions, NPP test0.10.20.20.4-0.40.4-0.4-0.4-0.4-0.40.5-0.50.50.5-0.50.5
Total locomotion distance, NPP test2.63.63.81.9-1.91.9-1.8-1.8-1.9-1.91.9-1.91.91.9-1.91.9
Locomotion velocity, NPP test2.53.53.71.9-1.91.8-1.8-1.8-1.9-1.91.9-1.91.91.9-1.91.9
Intraocular pressure0.40.60.70.8-0.80.7-0.7-0.7-0.8-0.80.9-0.90.80.9-0.80.8
Delta distance traveled before/after self-admin2.83.03.3-1.61.6-1.71.81.71.81.8-1.81.8-1.8-1.81.8-1.8
Delta ambulatory time before/after self-admin1.93.23.4-1.61.6-1.71.81.71.81.8-1.81.8-1.9-1.81.8-1.8
Parametrial fat weight2.04.75.52.4-2.42.3-2.2-2.3-2.2-2.12.1-2.12.12.1-2.02.0
Pavlov. Cond. lever latency0.00.00.0-0.00.0-0.0-0.00.0-0.0-0.00.0-0.00.00.0-0.00.0
Pavlov. Cond. magazine entry latency0.00.00.00.1-0.10.2-0.1-0.2-0.2-0.20.2-0.20.10.2-0.20.2
Pavlov. Cond. change in total contacts1.11.21.3-1.11.1-1.11.11.01.11.1-1.11.1-1.1-1.11.1-1.1
Pavlov. Cond. index score0.10.10.1-0.30.3-0.30.30.30.30.3-0.30.3-0.3-0.30.3-0.3
Pavlov. Cond. latency score0.00.00.0-0.10.1-0.10.20.10.20.2-0.20.2-0.2-0.20.2-0.2
Pavlov. Cond. lever contacts0.00.00.00.0-0.00.1-0.1-0.1-0.1-0.10.1-0.10.10.1-0.10.1
Pavlov. Cond. magazine entry number0.40.50.50.7-0.70.7-0.7-0.7-0.7-0.70.7-0.70.70.7-0.70.7
Pavlov. Cond. intertrial magazine entries0.10.10.20.4-0.40.3-0.3-0.3-0.4-0.40.4-0.40.40.4-0.40.4
Pavlov. Cond. lever-magazine prob. diff.0.20.20.3-0.50.5-0.50.50.40.50.5-0.50.5-0.5-0.50.5-0.5
Pavlov. Cond. response bias0.20.20.2-0.50.5-0.40.40.40.40.4-0.50.5-0.4-0.50.4-0.4
Pavlov. Cond. lever latency0.40.50.60.7-0.70.7-0.8-0.7-0.7-0.70.7-0.70.70.7-0.70.7
Pavlov. Cond. magazine entry latency0.00.10.10.0-0.00.2-0.2-0.2-0.3-0.30.3-0.30.30.3-0.30.3
Pavlov. Cond. change in total contacts0.81.92.1-1.41.4-1.41.51.41.41.4-1.31.3-1.4-1.31.4-1.4
Pavlov. Cond. index score0.30.50.7-0.90.9-0.80.80.70.70.7-0.60.6-0.7-0.60.7-0.7
Pavlov. Cond. latency score0.20.40.6-0.80.8-0.60.60.60.60.6-0.50.5-0.6-0.50.6-0.6
Pavlov. Cond. lever contacts0.20.20.3-0.50.5-0.50.60.50.50.5-0.40.4-0.5-0.40.5-0.5
Pavlov. Cond. magazine entry number0.00.00.00.1-0.1-0.10.10.10.20.2-0.20.2-0.2-0.20.2-0.2
Pavlov. Cond. intertrial magazine entries3.67.88.32.8-2.82.8-2.8-2.9-2.8-2.82.8-2.82.82.8-2.82.8
Pavlov. Cond. lever-magazine prob. diff.0.40.71.0-1.01.0-0.90.90.80.80.8-0.70.7-0.8-0.70.8-0.8
Pavlov. Cond. response bias0.20.30.4-0.60.6-0.60.60.60.50.5-0.50.5-0.6-0.50.5-0.5
Time in closed arm before self-admin1.11.92.2-1.31.3-1.21.31.21.41.4-1.51.5-1.5-1.51.5-1.5
Time in closed arm after self-admin0.00.00.0-0.00.0-0.10.20.10.20.2-0.20.2-0.2-0.20.2-0.2
Time in open arm before self-admin0.00.00.0-0.20.2-0.20.20.20.00.00.1-0.10.10.1-0.10.1
Time in open arm after self-admin0.00.00.10.1-0.10.1-0.1-0.0-0.2-0.20.2-0.20.20.2-0.20.2
Bone: periosteal estimation0.00.10.1-0.30.3-0.20.20.20.30.3-0.30.3-0.3-0.30.3-0.3
Bone: periosteal perimeter0.00.00.0-0.10.1-0.10.10.10.20.2-0.20.2-0.2-0.20.2-0.2
Bone: post-yield work0.10.20.20.5-0.50.5-0.5-0.5-0.4-0.40.4-0.40.40.4-0.40.4
Progressive ratio test 1 active lever presses0.10.10.2-0.40.4-0.40.30.30.30.3-0.30.3-0.3-0.30.3-0.3
Progressive ratio test 1 breakpoint0.10.20.3-0.50.5-0.50.40.40.40.4-0.40.4-0.4-0.40.4-0.4
Progressive ratio test 1 inactive lever presses0.41.11.20.8-0.81.0-1.1-1.1-1.1-1.11.1-1.11.11.1-1.11.1
Progressive ratio test 2 active lever presses0.00.00.00.2-0.20.2-0.2-0.2-0.2-0.20.2-0.20.20.2-0.20.2
Progressive ratio test 2 breakpoint0.00.00.00.1-0.10.1-0.2-0.1-0.1-0.10.1-0.10.10.1-0.10.1
Progressive ratio test 2 inactive lever presses0.10.40.50.5-0.50.6-0.7-0.6-0.6-0.60.6-0.60.60.6-0.60.6
Incentive Sensitization - Responses0.10.30.40.6-0.60.6-0.6-0.6-0.6-0.60.6-0.60.60.6-0.60.6
Incentive Sensitization - Breakpoint0.20.50.50.7-0.70.7-0.7-0.7-0.7-0.70.7-0.70.70.7-0.70.7
Sum of active levers in priming session hrs 5-60.10.10.10.2-0.20.2-0.2-0.1-0.3-0.30.3-0.30.30.3-0.30.3
Progressive ratio0.00.00.0-0.10.1-0.10.10.10.10.1-0.10.1-0.1-0.10.1-0.1
Food seeking constrained by brief footshock2.12.72.7-1.61.6-1.61.61.61.61.6-1.61.6-1.6-1.61.6-1.6
Seeking ratio, punishment vs. effort0.51.01.1-1.01.0-1.01.01.01.01.0-1.01.0-1.0-1.01.0-1.0
Retroperitoneal fat weight0.10.50.90.9-0.90.8-0.8-0.7-0.7-0.70.7-0.70.60.7-0.60.6
Reaction time number correct0.30.91.1-1.01.0-0.91.00.81.01.0-1.01.0-1.0-1.01.0-1.0
Reaction time mean minus median0.00.20.2-0.50.5-0.40.50.40.40.4-0.40.4-0.4-0.40.4-0.4
Reaction time mean minus median AUC0.00.10.2-0.40.4-0.40.40.30.30.3-0.30.3-0.3-0.30.3-0.3
Reaction time num false alarms0.10.10.2-0.10.1-0.20.20.20.30.3-0.40.4-0.4-0.40.4-0.4
Reaction time num false alarms AUC0.00.10.1-0.10.1-0.10.20.10.20.3-0.30.3-0.3-0.30.4-0.4
Reaction time trials correct on left0.30.91.1-1.01.0-0.91.00.81.01.0-1.01.0-1.0-1.01.0-1.0
Reaction time trials on left0.20.70.8-0.80.8-0.80.90.70.90.9-0.90.9-0.9-0.90.8-0.8
Reaction time mean0.10.30.4-0.60.6-0.60.60.60.50.5-0.50.5-0.5-0.50.4-0.4
Reaction time mean AUC0.20.50.7-0.80.8-0.80.80.80.70.7-0.60.6-0.7-0.60.6-0.6
Median of all reaction times0.10.20.4-0.60.6-0.60.60.50.50.4-0.40.4-0.4-0.40.4-0.4
Reaction time omissions1.52.52.61.5-1.51.5-1.6-1.5-1.6-1.61.6-1.61.61.6-1.61.6
Reaction time false alarm rate0.10.10.20.5-0.50.4-0.4-0.4-0.3-0.30.2-0.20.30.2-0.20.2
Reaction time premature initiation rate1.82.73.0-1.71.7-1.71.51.71.61.6-1.71.7-1.6-1.71.6-1.6
Reaction time premature initiations1.33.94.3-2.12.1-2.01.91.92.02.0-2.02.0-1.9-2.02.0-2.0
Std. dev. reaction times0.10.20.3-0.50.5-0.50.50.50.40.4-0.40.4-0.4-0.40.4-0.4
Reaction time trials completed0.20.70.8-0.80.8-0.80.90.70.90.9-0.90.9-0.9-0.90.8-0.8
Reaction time trials AUC0.20.70.7-0.80.8-0.70.80.70.80.8-0.90.9-0.8-0.90.8-0.8
Run reversals in cocaine runway, females2.83.13.31.8-1.81.8-1.7-1.8-1.8-1.81.8-1.81.71.8-1.71.7
Run reversals in cocaine runway, males1.82.02.0-1.41.4-1.41.41.41.41.4-1.41.4-1.4-1.41.4-1.4
Latency to leave start box in cocaine runway0.30.50.6-0.60.6-0.60.60.60.70.7-0.70.7-0.7-0.70.8-0.8
Latency to leave start box in cocaine runway, F1.21.41.7-1.21.2-1.21.21.21.21.2-1.21.2-1.3-1.21.3-1.3
Latency to leave start box in cocaine runway, M0.10.10.10.3-0.30.3-0.3-0.3-0.3-0.30.3-0.30.30.3-0.30.3
Std. dev. time between licks in bursts0.91.61.81.1-1.11.3-1.3-1.3-1.3-1.31.3-1.31.31.3-1.31.3
Total sessions with >9 infusions0.10.10.2-0.40.4-0.20.20.20.20.2-0.20.2-0.2-0.20.2-0.2
Short access day 1 total inactive lever presses0.10.10.20.3-0.30.4-0.4-0.4-0.4-0.40.4-0.40.40.4-0.40.4
Short access day 10 total inactive lever presses0.00.20.30.4-0.40.5-0.5-0.5-0.5-0.50.5-0.50.50.5-0.50.5
Short access day 1 total infusions0.00.10.1-0.40.4-0.30.20.20.30.3-0.30.3-0.3-0.30.3-0.3
Short access day 10 total infusions0.20.40.5-0.70.7-0.60.60.60.60.6-0.60.6-0.6-0.60.6-0.6
Short access total infusions0.00.10.1-0.30.3-0.20.20.20.20.2-0.20.2-0.2-0.20.2-0.2
Short access day 1 locomotion0.61.11.1-1.01.0-1.01.01.01.01.0-1.01.0-1.0-1.01.0-1.0
Short access day 10 total locomotion0.00.00.00.0-0.00.1-0.1-0.1-0.1-0.10.1-0.10.10.1-0.10.1
Short access total locomotion0.10.10.2-0.50.5-0.40.30.30.40.4-0.40.4-0.4-0.40.4-0.4
One hour access (0.3 mA shock)0.70.81.01.0-1.00.9-0.9-0.9-0.9-0.90.9-0.90.90.9-0.90.9
Compulsive drug intake0.60.81.21.1-1.10.9-0.9-0.9-0.9-0.90.9-0.90.90.9-0.90.9
One hour access (shock baseline)0.00.00.0-0.10.1-0.00.00.00.00.0-0.00.0-0.0-0.00.0-0.0
Social response proportion0.10.10.2-0.10.1-0.30.20.30.40.4-0.40.4-0.4-0.40.4-0.4
Social responses1.21.52.11.5-1.51.3-1.2-1.2-1.2-1.21.2-1.21.21.2-1.21.2
Social time0.30.50.91.0-1.00.9-0.8-0.8-0.7-0.70.6-0.60.70.6-0.60.6
Soleus weight1.33.83.8-2.02.0-2.01.92.01.91.9-1.91.9-1.9-1.91.9-1.9
Bone: stiffness0.61.11.2-1.11.1-1.01.01.01.11.1-1.11.1-1.1-1.11.1-1.1
Tibialis anterior weight8.328.731.4-5.65.6-5.55.35.45.35.3-5.35.3-5.3-5.35.3-5.3
Time to tail flick, vehicle, before self-admin0.70.91.00.9-0.90.9-0.9-0.8-1.0-1.01.0-1.01.01.0-1.01.0
Time to tail flick, vehicle, after self-admin1.02.12.7-1.61.6-1.51.41.51.41.4-1.41.4-1.4-1.41.4-1.4
Time to tail flick, test, before self-admin2.52.93.11.6-1.61.6-1.7-1.7-1.7-1.71.8-1.81.71.8-1.81.8
Time to tail flick, test, after self-admin2.42.52.91.7-1.71.6-1.5-1.5-1.6-1.61.6-1.61.61.6-1.61.6
Delta time to tail flick, vehicle, before/after SA0.30.30.3-0.60.6-0.50.40.50.50.5-0.50.5-0.5-0.50.5-0.5
Delta time to tail flick, test, before/after SA0.00.00.10.3-0.30.2-0.1-0.1-0.1-0.10.1-0.10.10.1-0.10.1
Tibia length1.23.43.91.7-1.71.9-1.9-2.0-1.8-1.81.8-1.81.81.8-1.81.8
Ambulatory time before self-admin0.10.40.5-0.70.7-0.70.70.70.60.6-0.60.6-0.6-0.60.6-0.6
Ambulatory time after self-admin3.76.06.4-2.32.3-2.42.52.42.52.5-2.52.5-2.5-2.52.5-2.5
Bone: tissue strength0.10.10.10.2-0.20.3-0.3-0.3-0.2-0.20.2-0.20.20.2-0.20.2
Total heroin consumption0.60.71.0-1.01.0-0.80.60.80.80.8-0.80.8-0.9-0.80.8-0.8
Bone: trabecular number2.03.74.11.9-1.92.0-2.0-2.0-1.9-1.91.9-1.91.91.9-1.91.9
Bone: trabecular spacing2.13.03.1-1.81.8-1.71.71.71.71.7-1.71.7-1.7-1.71.7-1.7
Bone: trabecular thickness1.01.41.41.1-1.11.1-1.2-1.2-1.2-1.21.2-1.21.21.2-1.21.2
Bone: trabecular tissue density1.11.92.2-1.31.3-1.41.51.51.41.4-1.41.4-1.4-1.41.4-1.4
Water consumed over 24 hours0.91.71.9-1.41.4-1.41.41.31.31.3-1.31.3-1.3-1.31.3-1.3
Number of responses in last shaping day0.60.81.1-1.11.1-0.90.80.80.80.8-0.80.8-0.8-0.80.8-0.8