Hub : Genes

Aldh3b3l-ps1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr1_201198745_201200051 0.03 0.03 7.7e-03 0.02 0.01 0.01 0.01 1.4e-03 9.9e-03 6.1e-02 1.7e-02
2 PL intron excision ratio chr1_201196081_201198646 0.04 0.03 2.8e-03 0.02 0.03 0.02 0.03 1.3e-03 6.6e-04 3.6e-03 8.4e-04
3 Brain intron excision ratio chr1_201243582_201243972 0.09 0.06 2.9e-05 0.03 0.04 0.05 0.05 8.0e-04 1.2e-04 2.3e-05 2.8e-05
4 IL intron excision ratio chr1_201244082_201244258 0.22 0.14 2.6e-03 0.03 0.07 0.04 0.07 8.4e-02 1.1e-02 5.0e-02 1.1e-02
5 Brain intron excision ratio chr1_201212851_201215435 0.07 0.05 2.0e-04 0.01 0.03 0.03 0.03 4.6e-02 5.2e-04 4.6e-04 1.5e-03
6 OFC intron excision ratio chr1_201248714_201250020 0.36 0.18 7.9e-05 0.05 0.12 0.15 0.12 2.1e-02 7.6e-04 2.1e-04 1.0e-03
7 OFC intron excision ratio chr1_201198745_201200051 0.35 0.18 1.2e-04 0.06 0.12 0.15 0.11 1.6e-02 1.0e-03 1.7e-04 1.7e-03
8 BLA intron excision ratio chr1_201212851_201215435 0.11 0.08 1.8e-04 0.02 0.05 0.02 0.04 2.2e-02 7.0e-04 1.8e-02 4.2e-03
9 Brain intron excision ratio chr1_201246038_201248615 0.11 0.08 1.4e-06 0.04 0.08 0.07 0.07 1.6e-04 1.5e-07 1.9e-07 2.4e-07
10 BLA intron excision ratio chr1_201244082_201244258 0.2 0.12 1.3e-08 0.12 0.14 0.12 0.14 6.2e-07 4.5e-08 5.3e-07 7.3e-08
11 PL intron excision ratio chr1_201244082_201244258 0.31 0.16 0.0e+00 0.19 0.26 0.26 0.26 2.8e-20 9.3e-29 9.9e-29 1.6e-28
12 Brain intron excision ratio chr1_201244082_201244258 0.14 0.09 1.3e-08 0.04 0.09 0.1 0.09 1.0e-04 4.3e-09 3.2e-09 4.3e-09
13 PL intron excision ratio chr1_201248714_201250020 0.11 0.07 1.9e-10 0.09 0.1 0.09 0.1 3.6e-10 3.4e-11 3.8e-10 7.4e-11
14 BLA intron excision ratio chr1_201246038_201248615 0.14 0.09 2.8e-06 0.12 0.1 0.1 0.1 1.1e-06 3.8e-06 3.8e-06 3.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density2.13.65.70.3-1.7-1.51.91.81.41.4-2.1-2.12.22.2-2.0-2.32.4
Area under the delay curve0.40.41.0-0.1-0.5-0.30.60.60.30.3-0.7-0.70.80.8-0.4-0.81.0
BMI with tail4.012.814.72.5-3.6-3.63.73.83.33.3-3.8-3.83.83.8-3.6-3.83.6
BMI without tail2.34.85.71.6-2.3-2.12.32.31.91.9-2.4-2.42.42.4-2.3-2.42.1
Body weight2.912.116.13.9-4.0-3.93.83.93.13.1-3.6-3.53.43.4-3.1-3.22.2
Weight adjusted by age1.21.42.91.7-1.2-1.51.11.31.41.3-1.0-1.00.90.9-1.2-0.90.6
Bone surface4.78.39.61.9-2.9-2.83.02.92.82.8-3.0-3.03.13.1-2.9-3.12.8
Bone volume2.23.74.90.8-1.8-1.61.91.81.91.9-2.1-2.12.22.2-1.8-2.22.2
Breakpoint value in progressive ratio session1.92.12.91.7-1.6-1.71.51.51.31.4-1.5-1.41.41.4-1.5-1.30.8
Number of licking bursts0.10.10.20.2-0.3-0.30.30.20.40.4-0.3-0.30.30.4-0.2-0.30.1
Context. condit. distance diff. score0.40.51.3-1.20.90.8-0.8-0.8-0.9-0.90.70.6-0.5-0.60.70.5-0.0
Locomotion velocity, session 10.00.00.00.0-0.1-0.20.10.1-0.1-0.1-0.1-0.10.10.1-0.0-0.10.1
Locomotion distance, session 11.92.43.30.8-1.4-1.51.51.51.41.4-1.6-1.61.71.7-1.7-1.71.8
Locomotion velocity, session 21.72.03.51.9-1.6-1.71.51.51.41.4-1.4-1.31.21.2-1.3-1.10.7
Locomotion distance, session 21.72.43.31.4-1.5-1.61.51.61.81.8-1.5-1.51.51.5-1.8-1.41.3
Locomotion velocity, session 30.91.02.6-0.2-0.9-0.71.01.00.50.5-1.1-1.21.21.2-0.8-1.31.6
Locomotion distance, session 30.10.10.30.0-0.2-0.20.20.40.30.3-0.3-0.30.30.3-0.2-0.30.6
Stereotopy head waving bouts, day 30.30.31.1-0.8-0.30.00.40.3-0.2-0.1-0.6-0.60.70.7-0.3-0.81.0
Stereotopy head waving duration, day 30.20.31.5-1.20.50.7-0.3-0.4-0.6-0.60.20.1-0.0-0.00.2-0.10.4
Locomotion velocity, session 70.60.71.7-0.0-0.6-0.70.70.80.40.4-0.8-0.90.90.9-1.0-1.01.3
Locomotion distance, session 70.50.61.40.7-0.7-0.90.70.80.60.7-0.7-0.70.70.7-1.2-0.70.6
Stereotopy head waving bouts, day 70.20.21.0-1.00.00.30.20.2-0.1-0.1-0.3-0.40.50.5-0.0-0.61.0
Stereotopy head waving duration, day 71.82.23.30.5-1.5-1.21.61.51.21.1-1.7-1.71.71.7-1.2-1.81.8
Locomotion velocity, session 81.11.31.91.4-1.3-1.41.31.31.11.0-1.2-1.11.11.1-0.8-1.00.6
Locomotion distance, session 80.00.00.3-0.30.1-0.1-0.00.00.20.2-0.1-0.10.20.2-0.3-0.20.5
Degree of sensitization distance0.60.61.50.6-0.7-0.90.80.70.60.6-0.8-0.80.80.8-1.2-0.80.7
Degree of sensitization stereotypy0.60.71.20.2-0.8-0.60.90.80.70.7-0.9-1.01.01.0-0.6-1.01.1
Conditioned locomotion0.50.63.92.0-0.7-0.80.40.41.11.1-0.2-0.1-0.1-0.0-0.20.2-1.0
Cocaine response after cond. corrected0.10.10.5-0.60.20.3-0.2-0.3-0.7-0.70.20.1-0.1-0.10.40.1-0.0
Cocaine response after cond. not corrected0.10.10.3-0.5-0.00.10.10.1-0.2-0.3-0.2-0.20.20.30.0-0.30.5
Cocaine response before conditioning0.30.41.00.4-0.5-0.50.50.61.01.0-0.5-0.50.50.5-0.7-0.50.7
Saline control response2.22.94.32.1-1.9-2.01.81.81.81.7-1.7-1.71.61.6-1.5-1.50.8
Bone: connectivity density4.97.69.61.5-2.8-2.62.92.82.22.2-3.0-3.03.13.1-3.0-3.12.8
Bone: cortical apparent density0.20.30.90.9-0.7-0.70.60.60.30.3-0.5-0.40.40.4-0.8-0.30.0
Bone: cortical area0.10.20.90.9-0.3-0.30.20.10.50.5-0.10.0-0.1-0.10.10.2-0.7
Bone: cortical porosity0.00.10.3-0.2-0.20.00.20.1-0.1-0.1-0.2-0.20.20.20.5-0.20.3
Bone: cortical porosity0.20.20.30.4-0.6-0.40.50.60.30.3-0.5-0.50.50.50.2-0.50.4
Bone: cortical thickness1.01.78.52.9-1.4-1.51.11.11.61.6-0.8-0.60.40.4-0.8-0.2-1.1
Bone: cortical thickness0.91.03.51.9-1.0-1.00.90.81.41.5-0.7-0.60.50.5-1.1-0.4-0.4
Bone: cortical tissue density0.30.31.01.0-0.7-0.80.60.70.40.4-0.5-0.50.40.4-0.8-0.30.0
Condit. Reinf. active minus inactive responses0.40.40.90.2-0.6-0.60.60.70.40.4-0.7-0.70.70.7-0.6-0.80.9
Condit. Reinf. active-inactive response ratio0.10.10.5-0.2-0.2-0.20.20.3-0.0-0.0-0.3-0.30.30.4-0.2-0.40.7
Condit. Reinf. active responses0.00.00.20.0-0.1-0.30.20.30.10.1-0.2-0.20.20.2-0.3-0.20.4
Condit. Reinf. inactive responses0.10.10.1-0.20.30.2-0.3-0.3-0.3-0.30.30.3-0.4-0.40.30.3-0.2
Incentive salience index mean0.40.50.80.5-0.6-0.80.60.80.70.7-0.7-0.70.70.7-0.8-0.70.9
Condit. Reinf. lever presses0.10.10.30.5-0.0-0.30.00.10.50.50.00.0-0.0-0.1-0.40.1-0.0
Condit. Reinf. active minus inactive responses0.20.21.1-1.00.00.20.10.1-0.2-0.2-0.3-0.40.50.5-0.3-0.61.1
Condit. Reinf. active-inactive response ratio0.60.62.7-1.60.91.0-0.7-0.8-0.9-0.90.60.5-0.4-0.40.60.30.2
Condit. Reinf. active responses0.70.92.7-0.4-0.7-0.50.90.90.60.6-1.0-1.11.21.2-0.9-1.31.6
Condit. Reinf. inactive responses1.82.22.50.9-1.5-1.41.51.61.41.4-1.6-1.61.61.6-1.4-1.61.6
Condit. Reinf. lever presses1.62.12.61.1-1.4-1.41.51.41.61.6-1.5-1.51.51.5-1.4-1.51.3
Condit. Reinf. lever reinforcers received0.91.33.0-0.1-1.0-0.81.11.10.70.7-1.3-1.31.41.4-1.1-1.51.7
Conditioned reinforcement - actives0.70.71.0-0.50.90.7-0.9-0.9-0.9-0.81.01.0-1.0-1.00.51.0-0.8
Conditioned reinforcement - inactives4.44.98.5-2.92.62.4-2.5-2.3-2.3-2.32.32.2-2.1-2.11.42.0-1.0
Conditioned locomotion9.611.614.8-3.23.83.6-3.8-3.5-3.1-3.13.73.6-3.5-3.53.33.4-2.3
Patch foraging indifference point 0 sec0.40.61.6-1.20.61.0-0.6-0.6-1.0-1.10.50.5-0.4-0.41.30.4-0.0
Patch foraging indifference point AUC0.50.62.31.5-0.9-1.00.71.00.80.8-0.6-0.50.50.5-0.3-0.30.2
Delay disc. indifference point, 0s delay0.80.92.0-0.2-0.7-0.40.90.90.70.7-1.0-1.11.21.2-0.7-1.21.4
Delay disc. indifference point, 16s delay0.70.71.6-1.31.01.1-0.9-0.9-0.9-0.90.80.7-0.7-0.60.90.6-0.2
Delay disc. indifference point, 2s delay0.10.10.3-0.50.10.20.00.0-0.2-0.2-0.1-0.20.20.2-0.1-0.30.6
Delay disc. indifference point, 24s delay0.10.10.4-0.00.00.2-0.1-0.3-0.5-0.50.20.2-0.2-0.20.60.3-0.6
Delay disc. indifference point, 4s delay0.30.31.00.2-0.4-0.40.50.70.50.5-0.6-0.60.60.6-0.1-0.61.0
Delay disc. indifference point, 8s delay0.30.30.50.0-0.5-0.40.60.50.10.1-0.6-0.70.70.7-0.2-0.70.5
Indifference point function ln k3.95.49.3-3.02.52.5-2.3-2.5-2.8-2.82.22.1-2.0-2.01.81.9-1.4
Indifference point function log k3.95.49.3-3.02.52.5-2.3-2.5-2.8-2.82.22.1-2.0-2.01.81.9-1.4
Patch foraging total patch changes 0 sec0.40.72.1-0.90.60.9-0.6-0.6-1.1-1.10.60.6-0.6-0.61.50.6-0.3
Patch foraging total patch changes 12 sec1.51.93.51.9-1.6-1.51.51.71.41.4-1.4-1.31.31.3-0.6-1.20.9
Patch foraging total patch changes 18 sec0.20.30.50.5-0.6-0.50.60.70.30.3-0.6-0.60.60.6-0.1-0.60.6
Patch foraging total patch changes 24 sec0.20.20.91.0-0.7-0.60.60.60.30.3-0.5-0.40.40.40.1-0.3-0.1
Patch foraging total patch changes 6 sec0.91.31.90.5-1.3-1.01.31.40.60.5-1.3-1.31.31.3-0.7-1.31.4
Patch foraging time to switch 0 sec4.06.18.31.8-2.3-2.42.42.42.72.7-2.5-2.52.52.6-2.9-2.52.3
Patch foraging water rate 0 sec7.812.515.9-2.83.53.6-3.6-3.5-3.5-3.63.63.6-3.6-3.74.03.6-3.0
Patch foraging water rate 12 sec10.215.617.8-3.34.03.9-4.1-4.0-4.0-4.14.14.1-4.1-4.14.24.0-3.4
Patch foraging water rate 18 sec2.23.03.6-1.61.81.8-1.8-1.8-1.9-1.91.71.7-1.7-1.71.71.6-1.4
Patch foraging water rate 24 sec4.66.47.7-1.82.42.6-2.5-2.6-2.5-2.52.62.6-2.6-2.72.82.6-2.6
Patch foraging water rate 6 sec3.55.26.0-1.52.22.0-2.3-2.3-2.4-2.42.42.4-2.4-2.42.22.4-2.4
Seeking ratio, delayed vs. immediate footshock0.40.50.9-0.1-0.7-0.50.80.60.20.2-0.9-0.90.90.9-0.6-1.00.8
Distance traveled before self-admin0.10.20.20.2-0.5-0.40.50.40.00.0-0.5-0.50.50.5-0.3-0.50.3
Distance traveled after self-admin0.00.00.3-0.0-0.1-0.00.2-0.00.20.2-0.2-0.20.20.2-0.5-0.2-0.1
Extensor digitorum longus weight4.015.837.06.1-4.4-4.84.04.24.44.4-3.6-3.43.23.2-3.6-2.91.3
Bone: elastic displacement2.12.44.6-0.31.31.3-1.5-1.5-1.2-1.21.61.7-1.7-1.71.91.8-2.1
Bone: elastic work0.20.31.71.3-0.6-0.50.40.30.10.1-0.2-0.1-0.0-0.00.30.2-0.9
Bone: endosteal estimation0.30.63.4-1.90.90.9-0.6-0.7-0.9-0.90.40.3-0.2-0.20.6-0.00.8
Bone: endosteal perimeter0.61.37.2-2.71.31.5-1.0-1.0-1.1-1.10.60.5-0.3-0.31.00.01.0
Epididymis fat weight2.25.28.3-2.92.72.6-2.5-2.4-2.2-2.22.32.2-2.1-2.12.31.9-1.0
Delta time in closed arm before/after self-admin0.20.21.21.1-0.6-0.70.50.60.40.4-0.4-0.30.20.3-0.1-0.1-0.1
Delta time in open arm before/after self-admin0.00.00.2-0.40.30.3-0.2-0.1-0.1-0.10.20.1-0.1-0.1-0.20.10.3
Diff in mean of infusions in LGA sessions0.10.10.60.7-0.5-0.50.40.20.20.2-0.3-0.30.30.3-0.2-0.2-0.4
Delay discount exponential model param0.30.30.80.10.50.4-0.5-0.6-0.2-0.20.60.7-0.7-0.70.30.8-0.9
Extinction: sum of active levers before priming4.04.05.41.9-2.3-2.32.31.91.51.5-2.2-2.12.12.1-2.2-2.01.2
Active lever presses in extinction session 60.20.21.61.3-0.4-0.60.20.40.50.5-0.00.0-0.1-0.1-0.10.3-0.4
Bone: final force1.72.73.41.8-1.8-1.71.71.61.81.9-1.7-1.61.61.6-1.6-1.50.8
Bone: final moment1.42.22.91.7-1.6-1.61.61.41.71.7-1.5-1.51.41.5-1.4-1.40.7
Food consumed during 24 hour testing period0.50.60.9-0.40.80.8-0.8-0.9-0.3-0.30.80.8-0.8-0.80.70.8-0.9
Glucose0.30.42.7-1.60.70.6-0.4-0.4-0.6-0.60.20.10.00.0-0.1-0.21.0
Heart weight0.91.33.1-1.81.21.3-1.0-1.2-1.7-1.70.90.9-0.8-0.70.90.7-0.4
Delay discount hyperbolic model param0.30.31.0-0.00.50.4-0.6-0.6-0.3-0.20.60.7-0.7-0.70.30.8-1.0
Intermittent access intake day 1-15 change2.52.53.4-1.41.61.4-1.6-1.8-1.8-1.71.61.5-1.5-1.51.41.5-1.5
Intermittent access intake escalation1.81.82.5-1.41.41.2-1.4-1.6-1.6-1.51.31.3-1.2-1.21.11.1-1.1
Intermittent access intake escalation 21.21.21.6-1.11.11.0-1.1-1.3-1.3-1.21.11.1-1.0-1.00.91.0-1.1
Intermitt. access day 1 inactive lever presses0.91.02.3-1.51.21.3-1.1-1.0-0.9-0.91.00.9-0.9-0.90.90.8-0.2
Intermitt. access day 15 inactive lever presses0.91.03.3-1.81.21.2-1.0-1.3-1.0-1.00.90.8-0.7-0.70.40.6-0.5
Intermitt. access escalation Index3.12.73.9-1.61.81.8-1.7-1.7-1.6-1.71.71.6-1.6-1.62.01.5-1.2
Intermittent access day 1 total infusions0.50.63.9-2.00.70.8-0.4-0.3-0.3-0.30.1-0.10.20.3-0.8-0.41.4
Intermittent access day 15 total infusions3.64.010.5-3.22.42.4-2.2-2.2-2.3-2.21.91.7-1.6-1.61.01.4-0.4
Intermittent access terminal intake (last 3 days)1.82.07.1-2.71.81.7-1.5-1.5-1.6-1.51.21.0-1.0-0.90.40.70.1
Intermittent access total infusions0.70.83.9-2.01.21.1-0.9-0.8-0.8-0.80.70.5-0.5-0.4-0.00.30.6
Intermittent access day 1 locomotion0.50.53.0-1.00.10.00.20.40.30.3-0.4-0.50.60.6-1.1-0.71.7
Intermittent access day 15 total locomotion2.02.14.8-2.21.91.7-1.6-1.5-1.5-1.51.51.3-1.3-1.20.81.1-0.2
Intermittent access total locomotion1.11.35.5-2.41.61.5-1.3-1.1-0.9-0.91.00.8-0.7-0.70.10.50.7
Intermittent access standard deviation0.80.81.1-1.11.00.9-1.0-1.0-0.9-0.80.90.9-0.9-0.80.70.8-0.7
Left kidney weight1.54.27.0-1.92.02.2-2.0-2.0-2.1-2.22.02.0-1.9-1.92.61.9-1.6
Right kidney weight1.64.47.1-1.52.12.1-2.1-2.1-2.0-2.02.12.1-2.1-2.12.72.1-1.9
Cocaine induced anxiety0.00.00.1-0.20.10.2-0.1-0.1-0.2-0.20.10.1-0.1-0.1-0.10.1-0.2
Post-drug Anxiety0.20.20.60.8-0.7-0.50.50.30.10.1-0.4-0.30.30.2-0.1-0.2-0.6
Baseline Anxiety0.60.61.81.3-1.1-1.00.90.70.70.7-0.8-0.70.60.6-0.3-0.5-0.2
Tail length0.10.31.81.3-0.6-0.50.40.30.20.2-0.2-0.1-0.0-0.0-0.20.2-1.0
Length with tail0.72.68.73.0-2.1-2.01.81.81.41.4-1.5-1.31.21.2-1.1-0.9-0.3
Length without tail1.12.45.22.3-2.0-2.01.81.91.41.3-1.6-1.51.31.3-1.1-1.20.5
Times rat made contact with spout0.91.01.40.6-1.1-1.01.21.00.90.8-1.2-1.21.21.2-0.5-1.21.0
Lifetime Intake0.50.63.4-1.81.00.9-0.7-0.6-0.6-0.60.50.4-0.3-0.3-0.20.10.8
Liver weight, left0.10.10.3-0.20.40.5-0.4-0.6-0.1-0.10.40.4-0.4-0.40.30.3-0.4
Liver weight, right0.30.51.1-0.00.60.6-0.7-0.6-0.4-0.40.80.8-0.8-0.81.10.8-0.8
Locomotor activity1.32.03.3-1.41.31.5-1.3-1.4-1.8-1.81.31.3-1.3-1.31.41.3-1.1
Locomotor testing distance1.62.74.9-1.81.51.7-1.5-1.6-2.2-2.21.41.5-1.4-1.41.81.4-1.2
Locomotor testing rearing0.40.72.2-1.50.80.8-0.7-0.7-1.3-1.30.50.5-0.4-0.40.60.30.1
Locomotion in novel chamber3.44.28.7-3.02.52.4-2.2-2.3-2.2-2.12.01.9-1.8-1.71.41.6-0.7
Locomotion in novel chamber post-restriction2.53.04.7-2.11.92.2-1.8-1.9-1.7-1.71.71.6-1.6-1.51.61.5-1.0
Fecal boli incidents, locomotor time 10.00.00.1-0.10.20.2-0.2-0.30.20.20.20.2-0.2-0.20.30.1-0.2
Change in fecal boli incidents, locomotor task0.40.40.50.4-0.7-0.70.70.70.30.3-0.7-0.70.70.7-0.6-0.70.5
Time >=10cm from walls, locomotor time 10.40.41.7-1.20.30.2-0.00.20.10.2-0.2-0.30.40.5-1.0-0.61.3
Bouts of movement, locomotor time 10.10.21.01.0-0.4-0.50.30.30.10.1-0.1-0.10.00.00.30.1-0.6
Total resting periods, locomotor time 10.10.10.40.6-0.1-0.20.00.1-0.1-0.10.10.2-0.2-0.20.50.3-0.7
Rest time, locomotor task time 12.62.83.3-1.31.71.7-1.8-1.8-1.5-1.51.81.8-1.8-1.71.81.7-1.6
Distance moved, locomotor task time 10.80.81.50.2-0.8-0.70.90.80.60.5-1.0-1.01.11.1-1.2-1.11.2
Vertical activity count, locomotor time 10.40.41.5-1.20.70.8-0.5-0.6-0.9-0.90.40.3-0.3-0.3-0.00.20.2
Time >=10cm from walls, locomotor time 20.20.20.3-0.30.50.4-0.5-0.3-0.1-0.10.60.6-0.6-0.50.40.5-0.3
Bouts of movement, locomotor time 20.30.30.70.8-0.6-0.70.50.50.80.7-0.5-0.40.40.4-0.2-0.30.1
Total resting periods, locomotor time 20.20.20.40.5-0.5-0.50.40.40.60.6-0.4-0.40.40.4-0.1-0.30.2
Rest time, locomotor task time 20.60.72.7-1.61.01.2-0.8-0.9-0.7-0.70.70.6-0.5-0.50.50.40.0
Distance moved, locomotor task time 20.10.10.90.9-0.4-0.50.30.20.10.1-0.2-0.10.10.00.00.0-0.4
Vertical activity count, locomotor time 20.91.02.50.20.60.6-0.8-0.9-0.8-0.81.01.1-1.1-1.11.11.2-1.6
Light reinforcement 10.81.42.2-0.81.31.3-1.3-1.2-1.0-1.01.31.3-1.3-1.21.51.2-0.9
Light reinforcement 22.83.75.5-1.82.12.1-2.1-2.0-1.7-1.72.02.0-1.9-2.02.41.9-1.2
Bone: marrow area0.30.63.5-1.90.90.9-0.7-0.7-0.9-0.90.40.3-0.2-0.20.50.00.8
Bone: maximum diameter0.20.30.6-0.40.60.6-0.6-0.6-0.5-0.50.60.6-0.6-0.60.70.6-0.6
Bone: maximum force3.15.36.41.6-2.4-2.22.42.22.22.2-2.5-2.52.52.5-2.2-2.52.1
Bone: maximum moment2.54.45.31.4-2.2-2.02.22.12.01.9-2.3-2.32.32.3-1.9-2.31.9
Mean time between licks in bursts0.40.51.10.8-1.0-0.90.90.80.10.2-0.8-0.80.70.8-0.7-0.70.1
Mean num. licks in bursts0.10.10.2-0.2-0.3-0.10.30.3-0.2-0.2-0.3-0.30.30.30.1-0.30.5
Cd content in liver1.61.82.3-1.41.51.5-1.5-1.5-1.1-1.11.41.4-1.3-1.31.31.3-1.0
Co content in liver0.91.11.7-0.21.00.9-1.1-0.9-0.5-0.61.21.2-1.3-1.21.21.3-1.1
Cu content in liver0.00.10.20.4-0.2-0.30.20.30.30.3-0.1-0.10.10.1-0.2-0.10.0
Fe content in liver0.00.00.10.1-0.2-0.30.20.3-0.3-0.3-0.1-0.10.10.1-0.2-0.10.2
K content in liver3.13.13.61.1-1.8-1.61.81.81.81.8-1.9-1.91.91.9-1.5-1.91.8
Mg content in liver1.81.84.10.0-1.0-0.81.21.21.41.4-1.4-1.51.51.5-1.1-1.62.0
Mn content in liver1.71.93.61.8-1.3-1.41.31.41.91.9-1.2-1.21.21.1-1.2-1.10.8
Na content in liver0.10.10.30.00.20.2-0.3-0.3-0.4-0.40.30.3-0.4-0.40.50.4-0.6
Rb content in liver0.30.42.1-1.40.20.50.00.0-0.1-0.1-0.2-0.40.50.4-0.1-0.61.3
Se content in liver0.10.20.7-0.6-0.1-0.10.20.2-0.0-0.0-0.4-0.40.50.5-0.4-0.50.9
Sr content in liver0.70.73.11.8-0.8-1.00.70.71.01.0-0.5-0.40.30.3-0.8-0.2-0.4
Zn content in liver0.70.71.41.2-0.9-0.80.80.81.21.2-0.8-0.70.70.7-0.9-0.60.2
Bone: minimum diameter0.20.42.0-1.40.20.40.10.0-0.1-0.1-0.3-0.40.60.50.1-0.71.3
Time in familiar zone, hab. session 10.10.10.5-0.70.30.3-0.2-0.2-0.4-0.40.20.1-0.1-0.1-0.10.00.4
Time in novel zone, hab. session 10.00.00.10.1-0.1-0.00.0-0.0-0.1-0.10.00.0-0.0-0.00.30.1-0.2
Total zone transitions, hab. session 10.81.12.21.1-0.9-1.10.91.01.51.5-0.9-0.90.90.9-1.2-0.80.8
Total locomotion distance, hab. session 10.10.10.4-0.50.60.4-0.5-0.4-0.1-0.00.40.4-0.3-0.3-0.30.30.1
Locomotion velocity, hab. session 10.00.10.2-0.00.30.0-0.3-0.10.30.30.20.2-0.2-0.2-0.50.10.1
Time in familiar zone, hab. session 20.10.10.60.8-0.3-0.30.20.10.10.1-0.00.0-0.1-0.10.00.2-0.6
Time in novel zone, hab. session 20.40.41.3-0.4-0.4-0.30.50.50.30.3-0.6-0.70.70.7-0.5-0.81.1
Total zone transitions, hab. session 24.96.47.81.4-2.3-2.22.52.52.82.8-2.6-2.62.72.7-2.7-2.72.8
Total locomotion distance, hab. session 20.91.12.20.2-0.7-0.80.90.91.11.1-1.0-1.11.11.1-1.5-1.21.5
Locomotion velocity, hab. session 20.50.61.7-0.1-0.4-0.40.60.60.80.8-0.7-0.80.90.8-1.2-0.91.3
Novel to familiar place preference ratio0.50.61.10.4-0.6-0.60.70.60.80.8-0.8-0.80.80.8-1.0-0.80.8
Novelty place preference0.30.30.70.0-0.4-0.30.50.40.50.5-0.6-0.60.60.6-0.8-0.70.8
Time in novel zone, NPP test0.30.30.60.0-0.4-0.40.50.40.50.5-0.6-0.60.70.7-0.8-0.70.8
Total zone transitions, NPP test2.43.44.71.6-1.7-1.91.71.92.12.1-1.8-1.81.81.8-2.2-1.81.7
Total locomotion distance, NPP test0.20.31.20.3-0.3-0.50.40.50.60.7-0.4-0.50.50.5-1.1-0.50.8
Locomotion velocity, NPP test0.10.20.80.2-0.1-0.40.20.30.50.5-0.3-0.30.30.3-0.9-0.40.6
Intraocular pressure1.31.83.1-0.61.31.3-1.4-1.5-0.9-0.91.41.5-1.5-1.51.41.5-1.8
Delta distance traveled before/after self-admin0.00.00.2-0.00.10.2-0.1-0.30.10.20.10.1-0.1-0.1-0.40.1-0.4
Delta ambulatory time before/after self-admin0.00.00.20.2-0.0-0.00.0-0.10.30.30.00.0-0.1-0.1-0.40.1-0.4
Parametrial fat weight0.51.03.4-1.81.21.3-1.0-0.9-1.1-1.10.80.7-0.5-0.60.90.40.5
Pavlov. Cond. lever latency0.40.51.1-0.80.60.8-0.6-0.6-1.0-1.00.60.6-0.6-0.60.70.6-0.6
Pavlov. Cond. magazine entry latency0.40.51.6-0.2-0.5-0.40.60.60.70.7-0.7-0.80.90.9-0.6-0.91.3
Pavlov. Cond. change in total contacts0.10.10.3-0.60.30.2-0.2-0.10.20.20.00.00.10.1-0.0-0.10.6
Pavlov. Cond. index score0.00.00.10.00.20.0-0.1-0.10.30.30.10.1-0.1-0.10.00.00.1
Pavlov. Cond. latency score0.10.10.30.1-0.0-0.20.10.10.60.6-0.1-0.10.20.2-0.2-0.20.4
Pavlov. Cond. lever contacts0.20.20.70.5-0.2-0.50.30.40.80.8-0.3-0.30.30.3-0.5-0.30.5
Pavlov. Cond. magazine entry number0.10.10.10.1-0.4-0.20.30.3-0.2-0.2-0.3-0.30.30.3-0.2-0.30.2
Pavlov. Cond. intertrial magazine entries0.80.91.3-0.50.90.8-0.9-0.9-1.1-1.11.01.0-1.0-1.01.11.0-1.1
Pavlov. Cond. lever-magazine prob. diff.0.00.00.20.10.0-0.10.00.10.40.4-0.0-0.00.10.1-0.1-0.10.2
Pavlov. Cond. response bias0.00.00.1-0.00.20.1-0.1-0.10.30.30.10.1-0.1-0.10.00.00.1
Pavlov. Cond. lever latency0.10.20.7-0.30.30.2-0.3-0.2-0.9-0.90.30.3-0.3-0.30.20.3-0.2
Pavlov. Cond. magazine entry latency4.55.26.21.9-2.4-2.32.42.32.52.5-2.4-2.42.42.3-2.0-2.31.9
Pavlov. Cond. change in total contacts0.81.11.80.6-1.0-0.81.00.91.31.3-1.1-1.11.11.1-0.9-1.21.0
Pavlov. Cond. index score1.51.93.21.2-1.3-1.31.41.31.81.8-1.4-1.41.41.4-1.3-1.41.0
Pavlov. Cond. latency score1.21.52.71.0-1.2-1.11.21.11.61.6-1.2-1.21.21.2-1.1-1.20.9
Pavlov. Cond. lever contacts0.00.10.30.3-0.0-0.0-0.0-0.00.60.60.00.1-0.1-0.10.10.1-0.2
Pavlov. Cond. magazine entry number5.97.28.7-2.32.72.6-2.8-2.7-3.0-3.02.72.7-2.7-2.72.72.6-2.2
Pavlov. Cond. intertrial magazine entries1.82.43.9-1.71.61.6-1.5-1.6-2.0-1.91.51.4-1.4-1.41.31.3-1.1
Pavlov. Cond. lever-magazine prob. diff.1.92.54.01.4-1.6-1.51.61.52.02.0-1.6-1.61.61.6-1.5-1.51.2
Pavlov. Cond. response bias1.01.32.51.1-1.1-1.11.11.11.61.6-1.1-1.11.11.1-1.0-1.10.8
Time in closed arm before self-admin0.00.10.1-0.30.30.3-0.2-0.10.40.40.20.1-0.1-0.10.00.00.3
Time in closed arm after self-admin0.00.00.20.50.0-0.1-0.10.10.30.30.10.1-0.2-0.20.10.2-0.1
Time in open arm before self-admin0.10.10.20.5-0.5-0.50.40.2-0.2-0.2-0.3-0.30.20.30.0-0.2-0.4
Time in open arm after self-admin0.00.00.1-0.00.00.0-0.1-0.1-0.3-0.30.10.1-0.1-0.1-0.00.1-0.2
Bone: periosteal estimation0.00.10.2-0.50.40.4-0.3-0.4-0.2-0.20.20.2-0.2-0.20.50.1-0.0
Bone: periosteal perimeter0.00.00.2-0.50.10.10.1-0.10.10.0-0.1-0.20.20.20.1-0.30.4
Bone: post-yield work2.73.710.6-0.8-1.3-1.01.71.61.31.2-2.0-2.22.42.3-1.7-2.63.3
Progressive ratio test 1 active lever presses1.21.32.1-1.51.31.2-1.3-1.1-1.2-1.21.21.1-1.1-1.10.51.1-0.4
Progressive ratio test 1 breakpoint1.31.32.0-1.41.31.3-1.3-1.1-1.2-1.21.21.2-1.2-1.20.61.1-0.5
Progressive ratio test 1 inactive lever presses0.20.20.8-0.90.60.4-0.5-0.3-0.4-0.40.50.4-0.4-0.40.10.40.3
Progressive ratio test 2 active lever presses2.02.14.3-2.11.71.6-1.6-1.5-1.7-1.61.51.4-1.3-1.30.71.2-0.4
Progressive ratio test 2 breakpoint3.33.75.3-2.32.22.1-2.1-2.0-2.1-2.12.01.9-1.9-1.91.31.8-1.0
Progressive ratio test 2 inactive lever presses3.54.010.1-3.22.62.4-2.3-2.1-1.9-1.92.01.8-1.8-1.70.91.5-0.4
Incentive Sensitization - Responses0.10.20.4-0.60.40.3-0.4-0.4-0.6-0.60.30.3-0.3-0.3-0.10.2-0.1
Incentive Sensitization - Breakpoint0.30.30.7-0.80.60.5-0.6-0.6-0.8-0.70.50.5-0.5-0.50.10.4-0.2
Sum of active levers in priming session hrs 5-61.01.02.90.30.60.5-0.9-0.9-0.9-0.91.01.1-1.2-1.20.61.3-1.7
Progressive ratio5.46.27.61.5-2.4-2.12.62.42.52.5-2.7-2.72.72.7-2.6-2.82.5
Food seeking constrained by brief footshock0.30.40.60.5-0.7-0.60.70.50.50.6-0.6-0.60.60.6-0.8-0.60.3
Seeking ratio, punishment vs. effort3.34.04.9-1.12.01.7-2.1-2.0-2.0-2.02.22.1-2.2-2.22.12.2-2.0
Retroperitoneal fat weight3.612.019.9-4.54.04.1-3.7-3.7-3.7-3.73.43.2-3.1-3.03.22.8-1.5
Reaction time number correct0.10.10.80.9-0.3-0.40.10.1-0.2-0.20.00.1-0.1-0.10.20.2-0.6
Reaction time mean minus median2.73.55.01.8-1.9-1.81.91.92.22.2-1.8-1.81.81.8-2.1-1.71.4
Reaction time mean minus median AUC1.41.82.61.6-1.5-1.41.41.41.51.5-1.3-1.21.21.2-1.5-1.10.7
Reaction time num false alarms0.30.51.0-0.10.40.5-0.5-0.5-0.9-0.90.60.6-0.7-0.70.80.8-1.0
Reaction time num false alarms AUC0.10.10.50.7-0.4-0.30.30.1-0.3-0.3-0.2-0.10.00.00.00.1-0.6
Reaction time trials correct on left0.10.10.80.9-0.3-0.40.10.1-0.2-0.20.00.1-0.1-0.10.20.2-0.6
Reaction time trials on left0.10.11.01.0-0.3-0.40.20.2-0.2-0.2-0.00.0-0.1-0.10.20.2-0.6
Reaction time mean0.40.51.70.4-0.3-0.40.40.51.31.3-0.5-0.50.50.6-1.2-0.60.7
Reaction time mean AUC0.30.51.40.2-0.3-0.30.40.51.21.2-0.4-0.50.50.5-1.1-0.60.8
Median of all reaction times0.20.31.1-0.0-0.0-0.20.20.20.70.8-0.3-0.30.40.4-1.1-0.40.7
Reaction time omissions1.31.83.31.8-1.5-1.51.41.41.51.4-1.3-1.21.21.2-1.4-1.00.6
Reaction time false alarm rate0.00.10.20.00.00.2-0.1-0.2-0.4-0.40.10.2-0.2-0.20.30.3-0.5
Reaction time premature initiation rate1.72.33.41.8-1.8-1.81.71.81.11.1-1.6-1.51.41.4-1.5-1.30.9
Reaction time premature initiations1.72.56.32.5-2.0-2.01.81.81.11.1-1.5-1.41.31.3-1.5-1.10.4
Std. dev. reaction times1.01.42.61.0-1.1-1.01.11.11.61.6-1.1-1.01.11.1-1.5-1.00.9
Reaction time trials completed0.10.11.01.0-0.3-0.40.20.2-0.2-0.2-0.00.0-0.1-0.10.20.2-0.6
Reaction time trials AUC0.10.10.70.8-0.3-0.40.10.1-0.2-0.3-0.00.0-0.1-0.10.20.2-0.5
Run reversals in cocaine runway, females3.02.94.91.1-1.7-1.71.81.71.31.3-1.8-1.81.81.8-2.2-1.81.7
Run reversals in cocaine runway, males0.20.21.10.40.20.2-0.3-0.4-0.2-0.20.40.4-0.5-0.50.40.6-1.1
Latency to leave start box in cocaine runway0.40.41.3-0.2-0.4-0.40.50.60.40.5-0.7-0.70.80.8-0.8-0.81.1
Latency to leave start box in cocaine runway, F0.40.40.80.1-0.5-0.50.60.60.70.7-0.7-0.70.70.7-0.7-0.80.9
Latency to leave start box in cocaine runway, M0.00.00.2-0.30.0-0.1-0.00.0-0.4-0.4-0.0-0.00.00.0-0.2-0.00.3
Std. dev. time between licks in bursts0.10.20.90.8-0.1-0.2-0.1-0.1-0.2-0.20.30.3-0.4-0.40.10.5-1.0
Total sessions with >9 infusions0.20.20.9-0.90.60.4-0.5-0.3-0.3-0.30.40.3-0.3-0.30.00.20.5
Short access day 1 total inactive lever presses1.51.74.4-2.11.51.5-1.4-1.5-1.4-1.41.31.1-1.1-1.10.71.0-0.4
Short access day 10 total inactive lever presses0.70.71.9-1.41.01.1-0.9-1.1-0.8-0.70.80.7-0.7-0.70.50.6-0.4
Short access day 1 total infusions0.50.63.4-1.90.90.9-0.7-0.7-0.7-0.70.50.4-0.3-0.30.10.20.5
Short access day 10 total infusions0.91.03.6-0.7-0.4-0.40.60.80.60.6-0.8-1.01.01.1-1.4-1.21.9
Short access total infusions0.20.31.4-0.90.1-0.00.10.20.10.1-0.3-0.40.40.4-0.8-0.51.2
Short access day 1 locomotion0.20.31.7-1.30.60.5-0.5-0.2-0.3-0.30.30.2-0.1-0.1-0.0-0.00.9
Short access day 10 total locomotion0.10.10.9-0.60.30.2-0.10.20.20.2-0.0-0.10.10.1-0.4-0.20.9
Short access total locomotion0.20.21.2-0.60.10.00.00.30.40.4-0.1-0.20.20.2-0.5-0.31.1
One hour access (0.3 mA shock)4.85.611.8-3.42.82.7-2.6-2.4-2.7-2.62.32.2-2.1-2.11.51.9-0.6
Compulsive drug intake1.21.23.61.9-1.5-1.51.31.31.00.9-1.1-0.90.90.8-0.6-0.70.1
One hour access (shock baseline)5.86.712.5-3.53.13.1-2.9-2.7-2.5-2.52.72.5-2.4-2.41.92.2-0.9
Social response proportion1.61.72.41.0-1.3-1.31.31.41.21.2-1.3-1.31.31.3-1.6-1.31.3
Social responses0.20.30.80.9-0.6-0.80.50.80.20.2-0.4-0.30.30.3-0.3-0.20.5
Social time0.50.71.21.0-0.9-1.10.91.10.50.5-0.8-0.80.80.8-0.7-0.70.8
Soleus weight4.613.516.3-3.54.03.9-4.0-3.9-3.6-3.63.83.8-3.7-3.73.63.5-2.5
Bone: stiffness2.84.45.51.3-2.0-1.92.22.02.02.0-2.2-2.32.32.3-2.2-2.32.1
Tibialis anterior weight3.010.340.46.4-3.6-4.13.13.23.83.8-2.5-2.21.91.9-2.3-1.4-0.5
Time to tail flick, vehicle, before self-admin2.02.13.00.6-1.4-1.11.51.01.51.6-1.6-1.61.71.7-1.3-1.71.2
Time to tail flick, vehicle, after self-admin2.62.83.81.7-1.8-1.91.81.91.61.5-1.7-1.71.61.6-1.5-1.61.5
Time to tail flick, test, before self-admin1.11.02.50.1-0.6-0.70.81.01.11.1-0.9-1.01.11.1-1.2-1.11.6
Time to tail flick, test, after self-admin0.30.31.50.6-0.2-0.10.2-0.11.21.2-0.2-0.10.10.10.4-0.1-0.5
Delta time to tail flick, vehicle, before/after SA0.60.61.61.0-0.8-1.10.71.30.40.3-0.6-0.60.50.5-0.6-0.50.9
Delta time to tail flick, test, before/after SA0.80.83.71.00.20.4-0.4-0.80.40.40.60.7-0.8-0.81.31.0-1.9
Tibia length0.20.52.00.50.40.4-0.5-0.50.00.00.70.8-0.8-0.80.80.9-1.4
Ambulatory time before self-admin0.20.20.30.1-0.4-0.30.50.30.00.1-0.5-0.50.50.6-0.2-0.60.4
Ambulatory time after self-admin0.10.10.5-0.70.10.20.1-0.10.10.2-0.2-0.30.30.3-0.6-0.40.5
Bone: tissue strength0.00.00.2-0.40.10.1-0.0-0.1-0.2-0.2-0.0-0.00.10.10.4-0.10.3
Total heroin consumption2.83.35.52.3-2.1-2.21.91.91.91.9-1.8-1.71.61.6-1.5-1.50.8
Bone: trabecular number2.13.24.60.5-1.6-1.41.81.71.51.5-2.0-2.02.12.1-1.9-2.12.2
Bone: trabecular spacing0.70.91.4-0.00.90.7-1.0-0.9-0.5-0.51.11.1-1.1-1.11.21.1-1.1
Bone: trabecular thickness0.30.41.4-1.2-0.10.20.30.2-0.2-0.2-0.5-0.60.70.7-0.4-0.81.1
Bone: trabecular tissue density6.28.710.6-2.73.33.2-3.2-3.1-2.9-2.83.13.1-3.0-3.02.72.9-2.2
Water consumed over 24 hours0.91.01.30.9-1.1-1.01.11.01.01.0-1.1-1.11.11.1-0.7-1.10.8
Number of responses in last shaping day0.40.40.7-0.80.80.6-0.8-0.5-0.6-0.60.80.7-0.7-0.80.30.7-0.1