Hub : Genes

Dock5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Dock5 0.12 0.11 3.8e-12 0.1 0.1 0.1 0.1 2.5e-11 1.8e-11 2.3e-11 4.0e-11
2 Adipose gene expression Dock5 0.12 0.1 2.3e-11 0.09 0.09 0.09 0.09 1.4e-10 1.5e-10 2.2e-10 2.1e-10
3 PL gene expression Dock5 0.04 0.04 1.6e-04 0.03 0.03 0.02 0.03 1.2e-04 1.4e-04 2.0e-03 4.1e-04
4 NAcc mRNA stability Dock5 0.05 0.04 4.8e-05 0.03 0.03 0.03 0.03 2.2e-04 1.4e-04 3.4e-04 4.9e-04
5 Brain alternative polyA XM_039093339.1 0.03 0.03 1.5e-03 0.02 0.03 0.02 0.02 8.4e-03 7.1e-04 3.2e-03 4.3e-03
6 Brain alternative polyA XM_039093338.1 0.04 0.03 1.2e-03 0.02 0.03 0.02 0.02 7.0e-03 5.3e-04 2.9e-03 3.1e-03
7 NAcc gene expression Dock5 0.08 0.07 4.1e-08 0.07 0.07 0.07 0.07 4.4e-08 2.5e-08 3.5e-08 3.2e-08
8 LHb gene expression Dock5 0.41 0.25 6.6e-07 0.2 0.21 0.18 0.19 1.4e-05 1.2e-05 4.0e-05 2.6e-05
9 Brain mRNA stability Dock5 0.06 0.05 1.7e-05 0.05 0.05 0.03 0.05 2.6e-05 1.4e-05 7.2e-04 4.2e-05
10 Brain gene expression Dock5 0.25 0.15 0.0e+00 0.26 0.26 0.26 0.26 1.6e-24 1.4e-24 7.1e-24 1.7e-24
11 Brain isoform ratio XM_039093339.1 0.04 0.04 1.1e-03 0.03 0.03 0.03 0.03 7.5e-04 9.2e-04 2.0e-03 2.0e-03
12 Liver gene expression Dock5 0.12 0.11 3.1e-12 0.1 0.1 0.1 0.1 2.5e-11 3.8e-11 1.1e-10 9.2e-11
13 Liver mRNA stability Dock5 0.02 0.02 6.5e-03 0.02 0.02 0.01 0.01 4.6e-03 5.1e-03 1.1e-02 1.1e-02
14 BLA mRNA stability Dock5 0.07 0.07 4.5e-03 0.01 0.01 -0 0.01 5.7e-02 8.4e-02 7.2e-01 6.0e-02
15 pVTA gene expression Dock5 0.37 0.25 1.8e-11 0.22 0.26 0.25 0.26 4.8e-10 1.4e-11 3.4e-11 2.0e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.83.03.21.7-1.7-1.71.71.7-1.71.71.71.71.7-1.8-1.8-1.8-1.81.7
Area under the delay curve0.10.10.1-0.30.20.2-0.3-0.30.3-0.3-0.3-0.3-0.30.20.20.20.2-0.3
BMI with tail0.31.11.2-1.01.01.0-1.0-1.01.0-1.0-1.0-1.0-1.01.11.11.11.0-1.0
BMI without tail0.81.62.01.3-1.2-1.21.31.3-1.31.31.31.31.3-1.2-1.2-1.2-1.41.3
Body weight0.41.71.8-1.31.31.3-1.3-1.31.3-1.3-1.3-1.3-1.31.21.21.21.2-1.3
Weight adjusted by age1.82.12.2-1.51.51.5-1.5-1.41.4-1.4-1.5-1.5-1.41.51.51.51.3-1.4
Bone surface0.71.31.51.1-1.1-1.11.11.1-1.11.11.11.11.2-1.1-1.1-1.1-1.21.1
Bone volume0.91.51.61.2-1.2-1.21.21.2-1.21.21.21.21.2-1.2-1.2-1.2-1.31.2
Breakpoint value in progressive ratio session0.00.00.1-0.20.20.2-0.2-0.20.2-0.2-0.2-0.2-0.2-0.3-0.3-0.30.1-0.2
Number of licking bursts0.00.00.0-0.10.20.2-0.1-0.00.0-0.1-0.1-0.1-0.00.10.10.1-0.0-0.0
Context. condit. distance diff. score0.91.11.31.0-0.9-0.91.01.0-1.01.01.01.01.0-1.1-1.1-1.1-1.11.0
Locomotion velocity, session 10.20.20.3-0.50.60.6-0.5-0.50.5-0.5-0.5-0.5-0.40.20.20.20.3-0.4
Locomotion distance, session 10.00.00.0-0.1-0.0-0.0-0.1-0.10.1-0.1-0.1-0.1-0.1-0.2-0.2-0.20.1-0.1
Locomotion velocity, session 20.00.00.00.0-0.1-0.10.00.0-0.00.00.00.1-0.00.20.20.20.20.0
Locomotion distance, session 20.00.00.00.0-0.1-0.10.00.0-0.00.00.00.1-0.0-0.0-0.0-0.00.00.0
Locomotion velocity, session 30.70.80.9-0.90.90.9-0.9-0.90.9-0.9-0.9-0.9-0.90.90.90.90.9-0.9
Locomotion distance, session 30.10.10.3-0.1-0.2-0.2-0.1-0.10.1-0.1-0.1-0.1-0.20.50.50.50.5-0.2
Stereotopy head waving bouts, day 30.70.81.3-0.91.21.2-0.9-0.90.9-0.9-0.9-0.9-0.80.70.70.70.8-0.9
Stereotopy head waving duration, day 32.22.74.0-1.72.02.0-1.7-1.71.7-1.7-1.7-1.7-1.61.31.31.31.5-1.7
Locomotion velocity, session 74.34.74.82.2-2.2-2.22.22.2-2.22.22.22.22.2-2.1-2.1-2.1-2.22.2
Locomotion distance, session 74.05.15.82.2-2.2-2.22.22.2-2.22.22.22.22.3-2.3-2.3-2.3-2.42.2
Stereotopy head waving bouts, day 71.92.12.5-1.41.61.6-1.4-1.41.4-1.4-1.4-1.3-1.41.51.51.51.5-1.4
Stereotopy head waving duration, day 72.73.23.7-1.71.81.8-1.7-1.71.7-1.7-1.7-1.7-1.81.91.91.91.9-1.8
Locomotion velocity, session 80.00.00.0-0.00.10.1-0.0-0.10.1-0.1-0.1-0.0-0.10.20.20.20.1-0.1
Locomotion distance, session 80.60.81.10.9-0.8-0.80.90.9-0.90.90.90.90.9-1.0-1.0-1.0-0.90.9
Degree of sensitization distance7.27.39.72.6-2.2-2.22.52.6-2.62.62.62.52.7-3.1-3.1-3.1-3.12.6
Degree of sensitization stereotypy1.31.41.8-1.11.21.2-1.1-1.11.1-1.1-1.1-1.1-1.21.41.41.41.3-1.1
Conditioned locomotion0.00.00.00.1-0.2-0.20.10.0-0.00.00.10.1-0.00.10.10.10.20.0
Cocaine response after cond. corrected0.40.50.7-0.70.60.6-0.7-0.70.7-0.7-0.7-0.7-0.70.70.70.70.8-0.7
Cocaine response after cond. not corrected0.30.30.5-0.50.40.4-0.5-0.60.6-0.6-0.5-0.5-0.60.70.70.70.7-0.6
Cocaine response before conditioning0.20.20.30.5-0.5-0.50.50.5-0.50.50.50.50.5-0.4-0.4-0.4-0.50.5
Saline control response0.30.40.50.6-0.6-0.60.60.6-0.60.60.60.60.7-0.7-0.7-0.7-0.70.6
Bone: connectivity density3.14.95.02.2-2.2-2.22.22.2-2.22.22.22.22.2-2.2-2.2-2.2-2.22.2
Bone: cortical apparent density0.10.10.30.2-0.2-0.20.20.2-0.20.20.20.20.3-0.6-0.6-0.6-0.30.3
Bone: cortical area0.00.00.10.1-0.2-0.20.10.1-0.10.10.10.10.2-0.0-0.0-0.0-0.20.1
Bone: cortical porosity1.51.71.8-1.31.31.3-1.3-1.31.3-1.3-1.3-1.3-1.31.31.31.31.3-1.3
Bone: cortical porosity0.70.70.9-0.80.80.8-0.8-0.80.8-0.8-0.8-0.8-0.90.90.90.90.9-0.8
Bone: cortical thickness0.00.00.10.2-0.3-0.30.20.2-0.20.20.20.20.2-0.1-0.1-0.1-0.20.2
Bone: cortical thickness0.00.00.10.2-0.2-0.20.20.2-0.20.20.20.20.2-0.1-0.1-0.1-0.20.2
Bone: cortical tissue density0.10.10.30.2-0.1-0.10.20.2-0.20.20.20.20.2-0.5-0.5-0.5-0.30.2
Condit. Reinf. active minus inactive responses0.60.60.8-0.80.90.9-0.8-0.80.8-0.8-0.8-0.8-0.80.60.60.60.8-0.8
Condit. Reinf. active-inactive response ratio2.52.72.9-1.71.71.7-1.7-1.71.7-1.7-1.7-1.7-1.71.51.51.51.7-1.7
Condit. Reinf. active responses0.00.00.0-0.10.20.2-0.1-0.10.1-0.1-0.1-0.1-0.1-0.1-0.1-0.10.1-0.1
Condit. Reinf. inactive responses2.93.53.61.9-1.8-1.81.91.9-1.91.91.91.91.9-1.9-1.9-1.9-1.91.9
Incentive salience index mean0.91.11.3-1.11.11.1-1.1-1.11.1-1.1-1.1-1.1-1.10.90.90.91.1-1.1
Condit. Reinf. lever presses0.40.50.7-0.70.60.6-0.7-0.70.7-0.7-0.7-0.7-0.80.60.60.60.8-0.7
Condit. Reinf. active minus inactive responses0.30.40.50.7-0.5-0.50.70.7-0.70.70.70.70.7-0.6-0.6-0.6-0.70.7
Condit. Reinf. active-inactive response ratio0.10.10.2-0.30.40.4-0.3-0.30.3-0.3-0.3-0.3-0.30.30.30.30.2-0.3
Condit. Reinf. active responses0.91.21.41.2-1.0-1.01.21.2-1.21.21.21.21.2-1.0-1.0-1.0-1.21.2
Condit. Reinf. inactive responses2.22.83.01.7-1.6-1.61.71.7-1.71.71.71.71.7-1.5-1.5-1.5-1.71.7
Condit. Reinf. lever presses0.10.10.20.3-0.3-0.30.30.4-0.40.40.30.30.4-0.1-0.1-0.1-0.40.4
Condit. Reinf. lever reinforcers received0.60.91.11.0-0.8-0.81.01.0-1.01.01.01.01.0-0.8-0.8-0.8-1.11.0
Conditioned reinforcement - actives2.72.72.91.7-1.7-1.71.71.7-1.71.61.71.71.6-1.7-1.7-1.7-1.61.6
Conditioned reinforcement - inactives3.13.53.91.9-1.8-1.81.91.9-1.91.91.91.91.9-1.8-1.8-1.8-2.01.9
Conditioned locomotion1.01.31.61.1-1.1-1.11.11.1-1.11.11.11.11.1-1.3-1.3-1.3-1.01.1
Patch foraging indifference point 0 sec2.33.84.21.9-2.0-2.01.91.9-1.91.91.91.91.9-2.0-2.0-2.0-2.01.9
Patch foraging indifference point AUC0.81.01.3-1.00.90.9-1.0-1.01.0-1.0-1.0-1.0-1.01.11.11.11.0-1.0
Delay disc. indifference point, 0s delay0.20.20.40.4-0.3-0.30.30.4-0.40.40.40.30.4-0.6-0.6-0.6-0.60.4
Delay disc. indifference point, 16s delay0.40.40.40.6-0.7-0.70.60.6-0.60.60.60.60.6-0.6-0.6-0.6-0.60.6
Delay disc. indifference point, 2s delay1.51.71.7-1.31.31.3-1.3-1.31.3-1.3-1.3-1.3-1.31.31.31.31.2-1.3
Delay disc. indifference point, 24s delay0.20.20.3-0.60.50.5-0.6-0.60.6-0.6-0.6-0.6-0.50.30.30.30.4-0.5
Delay disc. indifference point, 4s delay1.61.72.0-1.31.31.3-1.3-1.31.3-1.3-1.3-1.3-1.31.41.41.41.2-1.3
Delay disc. indifference point, 8s delay0.00.00.0-0.10.00.0-0.1-0.10.1-0.1-0.1-0.1-0.1-0.2-0.2-0.2-0.0-0.1
Indifference point function ln k0.00.00.10.1-0.1-0.10.10.1-0.10.10.10.10.1-0.3-0.3-0.3-0.20.1
Indifference point function log k0.00.00.10.1-0.1-0.10.10.1-0.10.10.10.10.1-0.3-0.3-0.3-0.20.1
Patch foraging total patch changes 0 sec2.03.23.61.7-1.8-1.81.71.7-1.71.71.71.71.8-1.9-1.9-1.9-1.91.7
Patch foraging total patch changes 12 sec0.60.81.00.9-1.0-1.00.90.9-0.90.90.90.90.9-0.8-0.8-0.8-1.00.9
Patch foraging total patch changes 18 sec1.72.12.71.5-1.6-1.61.51.5-1.51.51.51.51.5-1.3-1.3-1.3-1.41.5
Patch foraging total patch changes 24 sec0.00.00.0-0.10.00.0-0.1-0.10.1-0.1-0.1-0.1-0.10.10.10.10.1-0.1
Patch foraging total patch changes 6 sec0.40.60.80.7-0.7-0.70.70.7-0.70.70.70.70.7-0.9-0.9-0.9-0.90.7
Patch foraging time to switch 0 sec0.71.11.41.1-1.2-1.21.11.1-1.11.11.11.11.0-1.0-1.0-1.0-0.81.0
Patch foraging water rate 0 sec0.50.81.1-0.80.80.8-0.8-0.80.8-0.8-0.8-0.8-0.91.11.11.10.8-0.9
Patch foraging water rate 12 sec0.50.81.0-0.80.80.8-0.8-0.80.8-0.8-0.8-0.8-0.81.01.01.00.9-0.8
Patch foraging water rate 18 sec2.63.54.1-1.92.02.0-1.9-1.91.9-1.9-1.9-1.9-1.91.71.71.71.7-1.9
Patch foraging water rate 24 sec0.10.10.2-0.30.40.4-0.3-0.30.3-0.3-0.3-0.3-0.30.10.10.10.2-0.3
Patch foraging water rate 6 sec2.43.54.1-1.81.91.9-1.8-1.81.8-1.8-1.8-1.8-1.82.02.02.01.8-1.8
Seeking ratio, delayed vs. immediate footshock0.70.81.20.9-1.1-1.10.90.9-0.90.90.90.90.8-1.0-1.0-1.0-0.60.9
Distance traveled before self-admin0.80.91.1-0.91.01.0-0.9-0.90.9-0.9-0.9-1.0-1.00.80.80.81.0-0.9
Distance traveled after self-admin2.22.43.0-1.61.71.7-1.7-1.61.6-1.6-1.6-1.7-1.61.11.11.11.6-1.6
Extensor digitorum longus weight12.749.950.7-7.16.96.9-7.1-7.17.1-7.1-7.1-7.1-7.17.07.07.07.0-7.1
Bone: elastic displacement0.40.40.80.7-0.9-0.90.70.7-0.70.70.70.70.6-0.5-0.5-0.5-0.60.6
Bone: elastic work0.30.30.60.6-0.7-0.70.60.6-0.60.60.60.60.6-0.4-0.4-0.4-0.50.6
Bone: endosteal estimation0.00.10.2-0.30.50.5-0.3-0.30.3-0.3-0.3-0.3-0.20.20.20.20.0-0.3
Bone: endosteal perimeter0.00.10.1-0.20.30.3-0.2-0.20.2-0.2-0.2-0.2-0.20.20.20.20.0-0.2
Epididymis fat weight2.04.65.02.2-2.2-2.22.22.2-2.22.22.22.22.2-1.8-1.8-1.8-2.22.2
Delta time in closed arm before/after self-admin1.31.21.71.1-1.3-1.31.11.1-1.11.11.11.21.1-0.8-0.8-0.8-1.01.1
Delta time in open arm before/after self-admin0.20.20.20.4-0.3-0.30.40.4-0.40.40.40.40.5-0.4-0.4-0.4-0.50.4
Diff in mean of infusions in LGA sessions1.61.82.3-1.41.51.5-1.4-1.41.4-1.4-1.4-1.4-1.41.01.01.01.2-1.4
Delay discount exponential model param0.30.30.30.6-0.5-0.50.60.6-0.60.60.60.60.5-0.5-0.5-0.5-0.50.5
Extinction: sum of active levers before priming3.23.25.31.6-1.7-1.71.61.6-1.61.61.61.61.6-2.3-2.3-2.3-1.81.6
Active lever presses in extinction session 60.30.31.00.3-0.1-0.10.30.3-0.30.30.30.30.3-1.0-1.0-1.0-0.40.3
Bone: final force0.00.10.1-0.30.40.4-0.3-0.30.3-0.3-0.3-0.3-0.30.20.20.20.1-0.3
Bone: final moment0.00.00.1-0.20.30.3-0.2-0.20.2-0.2-0.2-0.2-0.20.00.00.0-0.1-0.2
Food consumed during 24 hour testing period0.40.50.90.7-0.6-0.60.70.7-0.70.70.70.70.8-0.8-0.8-0.8-0.90.7
Glucose0.00.00.10.2-0.2-0.20.20.2-0.20.20.20.20.2-0.2-0.2-0.2-0.30.2
Heart weight0.10.10.30.3-0.2-0.20.30.3-0.30.30.30.30.4-0.4-0.4-0.4-0.50.4
Delay discount hyperbolic model param0.60.60.70.8-0.7-0.70.80.8-0.80.80.80.80.8-0.8-0.8-0.8-0.70.8
Intermittent access intake day 1-15 change1.81.82.01.3-1.4-1.41.31.3-1.31.31.31.31.3-1.2-1.2-1.2-1.41.3
Intermittent access intake escalation1.21.21.41.2-1.1-1.11.21.2-1.21.21.21.21.2-0.7-0.7-0.7-1.21.2
Intermittent access intake escalation 20.30.30.40.6-0.6-0.60.60.6-0.60.60.60.60.7-0.2-0.2-0.2-0.70.6
Intermitt. access day 1 inactive lever presses0.10.10.10.3-0.3-0.30.30.3-0.30.30.30.30.3-0.0-0.0-0.0-0.30.3
Intermitt. access day 15 inactive lever presses0.00.00.00.1-0.1-0.10.10.1-0.10.10.10.10.1-0.1-0.1-0.1-0.10.1
Intermitt. access escalation Index0.60.61.2-0.60.60.6-0.6-0.60.6-0.6-0.6-0.6-0.61.11.11.10.6-0.6
Intermittent access day 1 total infusions0.00.10.20.2-0.2-0.20.20.2-0.20.20.20.20.1-0.4-0.4-0.4-0.00.2
Intermittent access day 15 total infusions0.91.01.01.0-1.0-1.01.01.0-1.01.01.01.01.0-0.9-0.9-0.9-1.01.0
Intermittent access terminal intake (last 3 days)0.20.20.20.4-0.4-0.40.50.4-0.40.40.40.50.4-0.3-0.3-0.3-0.40.4
Intermittent access total infusions0.40.50.60.7-0.7-0.70.70.7-0.70.70.70.70.6-0.7-0.7-0.7-0.60.7
Intermittent access day 1 locomotion0.30.30.40.6-0.6-0.60.60.6-0.60.60.60.60.6-0.6-0.6-0.6-0.50.6
Intermittent access day 15 total locomotion1.41.51.61.2-1.3-1.31.21.2-1.21.21.21.21.2-1.2-1.2-1.2-1.21.2
Intermittent access total locomotion0.40.50.50.7-0.7-0.70.70.7-0.70.70.70.70.7-0.6-0.6-0.6-0.60.7
Intermittent access standard deviation1.11.11.21.1-1.1-1.11.11.1-1.11.11.11.11.1-0.8-0.8-0.8-1.11.1
Left kidney weight0.20.60.8-0.80.90.9-0.8-0.80.8-0.8-0.8-0.8-0.80.60.60.60.8-0.8
Right kidney weight0.10.40.70.6-0.5-0.50.60.6-0.60.60.60.60.6-0.8-0.8-0.8-0.60.6
Cocaine induced anxiety0.10.20.3-0.40.40.4-0.4-0.40.4-0.4-0.4-0.4-0.40.50.50.50.3-0.4
Post-drug Anxiety0.60.61.10.7-0.7-0.70.70.7-0.70.70.70.70.7-1.0-1.0-1.0-0.70.7
Baseline Anxiety0.80.91.40.9-0.9-0.90.90.9-0.90.90.90.90.9-1.2-1.2-1.2-0.80.9
Tail length0.92.63.11.6-1.5-1.51.61.6-1.61.61.61.61.6-1.7-1.7-1.7-1.81.6
Length with tail0.10.30.4-0.60.60.6-0.6-0.60.6-0.6-0.6-0.6-0.60.50.50.50.5-0.6
Length without tail4.08.99.4-3.02.82.8-3.0-3.03.0-3.0-3.0-3.0-3.03.03.03.03.1-3.0
Times rat made contact with spout0.70.81.10.8-0.7-0.70.80.9-0.90.90.80.80.9-1.0-1.0-1.0-1.00.9
Lifetime Intake0.40.50.70.7-0.7-0.70.70.7-0.70.70.70.70.7-0.8-0.8-0.8-0.60.7
Liver weight, left1.93.03.5-1.81.91.9-1.8-1.71.7-1.7-1.7-1.8-1.71.71.71.71.6-1.7
Liver weight, right0.91.42.1-1.11.11.1-1.1-1.11.1-1.1-1.1-1.1-1.11.41.41.41.2-1.1
Locomotor activity1.52.32.4-1.51.51.5-1.5-1.51.5-1.5-1.5-1.5-1.51.61.61.61.5-1.5
Locomotor testing distance0.00.00.00.1-0.2-0.20.10.1-0.10.10.10.10.1-0.0-0.0-0.0-0.20.1
Locomotor testing rearing0.30.40.60.6-0.8-0.80.60.6-0.60.60.60.60.6-0.6-0.6-0.6-0.60.6
Locomotion in novel chamber0.10.20.30.4-0.4-0.40.40.4-0.40.40.40.40.5-0.1-0.1-0.1-0.60.4
Locomotion in novel chamber post-restriction0.60.71.1-1.00.80.8-1.0-1.01.0-1.0-1.0-1.0-1.00.30.30.31.0-1.0
Fecal boli incidents, locomotor time 10.50.50.8-0.80.90.9-0.8-0.80.8-0.8-0.8-0.8-0.70.40.40.40.6-0.8
Change in fecal boli incidents, locomotor task0.20.10.3-0.30.30.3-0.3-0.30.3-0.3-0.3-0.3-0.40.50.50.50.5-0.3
Time >=10cm from walls, locomotor time 11.11.21.51.1-0.9-0.91.11.1-1.11.11.11.11.1-1.2-1.2-1.2-1.21.1
Bouts of movement, locomotor time 15.56.06.3-2.52.42.4-2.5-2.52.5-2.5-2.5-2.5-2.52.32.32.32.5-2.5
Total resting periods, locomotor time 15.46.06.4-2.52.42.4-2.5-2.52.5-2.5-2.5-2.5-2.52.32.32.32.4-2.5
Rest time, locomotor task time 13.43.73.9-2.01.81.8-2.0-2.02.0-2.0-2.0-2.0-1.91.91.91.91.9-2.0
Distance moved, locomotor task time 12.32.52.71.7-1.6-1.61.71.7-1.71.71.71.71.6-1.4-1.4-1.4-1.61.6
Vertical activity count, locomotor time 10.60.61.00.9-1.0-1.00.90.9-0.90.90.90.90.8-0.2-0.2-0.2-0.70.8
Time >=10cm from walls, locomotor time 20.30.30.5-0.60.70.7-0.6-0.60.6-0.6-0.6-0.6-0.60.30.30.30.6-0.6
Bouts of movement, locomotor time 23.74.04.3-2.02.12.1-2.0-2.02.0-2.0-2.0-2.0-2.01.81.81.81.9-2.0
Total resting periods, locomotor time 24.24.54.8-2.22.22.2-2.2-2.22.2-2.2-2.2-2.2-2.12.02.02.02.0-2.1
Rest time, locomotor task time 21.01.21.3-1.11.01.0-1.1-1.11.1-1.1-1.1-1.1-1.11.11.11.11.1-1.1
Distance moved, locomotor task time 22.22.52.61.6-1.6-1.61.61.6-1.61.61.61.61.6-1.5-1.5-1.5-1.61.6
Vertical activity count, locomotor time 20.20.20.30.5-0.6-0.60.50.5-0.50.50.50.50.5-0.4-0.4-0.4-0.40.5
Light reinforcement 13.86.97.32.7-2.5-2.52.72.7-2.72.72.72.72.7-2.5-2.5-2.5-2.72.7
Light reinforcement 21.62.12.21.5-1.4-1.41.51.5-1.51.51.51.51.5-1.3-1.3-1.3-1.51.5
Bone: marrow area0.00.00.1-0.20.30.3-0.2-0.10.1-0.1-0.2-0.2-0.10.00.00.0-0.1-0.1
Bone: maximum diameter0.30.50.6-0.70.60.6-0.7-0.70.7-0.7-0.7-0.7-0.70.80.80.80.6-0.7
Bone: maximum force0.10.20.3-0.50.50.5-0.5-0.50.5-0.5-0.5-0.5-0.50.40.40.40.3-0.5
Bone: maximum moment0.00.10.1-0.30.40.4-0.3-0.30.3-0.3-0.3-0.3-0.30.20.20.20.1-0.3
Mean time between licks in bursts2.02.82.81.7-1.7-1.71.71.7-1.71.71.71.71.7-1.7-1.7-1.7-1.71.7
Mean num. licks in bursts0.40.50.60.7-0.7-0.70.70.7-0.70.70.70.70.7-0.8-0.8-0.8-0.70.7
Cd content in liver0.20.30.30.5-0.5-0.50.50.5-0.50.50.50.50.5-0.6-0.6-0.6-0.50.5
Co content in liver3.94.65.2-2.22.32.3-2.2-2.22.2-2.2-2.2-2.2-2.22.02.02.02.1-2.2
Cu content in liver0.70.80.9-0.90.90.9-0.9-0.90.9-0.9-0.9-0.9-1.00.80.80.81.0-0.9
Fe content in liver2.22.72.81.7-1.6-1.61.71.7-1.71.71.71.71.6-1.5-1.5-1.5-1.61.7
K content in liver0.40.40.50.7-0.7-0.70.70.7-0.70.70.70.70.7-0.4-0.4-0.4-0.50.7
Mg content in liver1.01.01.21.1-1.1-1.11.11.1-1.01.11.11.11.0-0.8-0.8-0.8-0.91.0
Mn content in liver2.12.32.51.6-1.5-1.51.61.6-1.61.61.61.51.6-1.4-1.4-1.4-1.61.6
Na content in liver0.80.80.9-0.90.90.9-0.9-0.90.9-0.9-0.9-0.9-0.90.90.90.91.0-0.9
Rb content in liver0.30.30.40.6-0.6-0.60.60.6-0.60.60.60.60.6-0.4-0.4-0.4-0.50.6
Se content in liver0.70.91.21.0-1.1-1.11.01.0-1.01.01.01.01.0-0.7-0.7-0.7-0.81.0
Sr content in liver0.30.30.30.6-0.6-0.60.50.6-0.60.60.60.50.5-0.5-0.5-0.5-0.60.6
Zn content in liver1.01.11.2-1.11.11.1-1.1-1.11.1-1.1-1.1-1.1-1.11.01.01.01.1-1.1
Bone: minimum diameter0.00.10.1-0.30.30.3-0.3-0.30.3-0.3-0.3-0.3-0.30.30.30.30.1-0.3
Time in familiar zone, hab. session 10.00.00.1-0.10.20.2-0.1-0.10.1-0.1-0.1-0.1-0.10.10.10.1-0.0-0.1
Time in novel zone, hab. session 11.31.31.3-1.21.11.1-1.2-1.21.2-1.2-1.2-1.2-1.11.11.11.11.2-1.2
Total zone transitions, hab. session 10.20.30.5-0.60.70.7-0.6-0.60.6-0.6-0.6-0.6-0.60.30.30.30.4-0.6
Total locomotion distance, hab. session 10.00.00.1-0.00.20.2-0.00.0-0.0-0.0-0.0-0.00.0-0.2-0.2-0.2-0.10.0
Locomotion velocity, hab. session 10.10.10.30.3-0.1-0.10.30.3-0.30.30.30.30.3-0.6-0.6-0.6-0.40.3
Time in familiar zone, hab. session 21.81.92.9-1.31.71.7-1.3-1.31.3-1.3-1.3-1.3-1.31.31.31.31.2-1.3
Time in novel zone, hab. session 20.70.71.10.8-1.0-1.00.80.8-0.80.80.80.80.7-0.8-0.8-0.8-0.70.8
Total zone transitions, hab. session 21.72.22.5-1.51.41.4-1.5-1.51.5-1.5-1.5-1.5-1.51.41.41.41.6-1.5
Total locomotion distance, hab. session 20.40.50.8-0.70.80.8-0.7-0.70.7-0.7-0.7-0.7-0.80.60.60.60.9-0.7
Locomotion velocity, hab. session 20.81.01.4-1.01.11.1-1.0-1.01.0-1.0-1.0-1.0-1.10.90.90.91.2-1.0
Novel to familiar place preference ratio1.31.42.21.2-1.5-1.51.21.2-1.21.21.21.21.1-1.1-1.1-1.1-0.91.1
Novelty place preference1.01.01.71.0-1.3-1.31.01.0-1.01.01.01.00.9-0.9-0.9-0.9-0.81.0
Time in novel zone, NPP test0.50.51.00.7-1.0-1.00.70.7-0.70.70.70.70.6-0.6-0.6-0.6-0.50.7
Total zone transitions, NPP test0.10.10.20.3-0.3-0.30.30.3-0.30.30.30.30.3-0.4-0.4-0.4-0.30.3
Total locomotion distance, NPP test2.43.33.51.8-1.7-1.71.81.8-1.81.81.81.81.8-1.9-1.9-1.9-1.81.8
Locomotion velocity, NPP test2.33.23.41.8-1.7-1.71.81.8-1.81.81.81.81.8-1.8-1.8-1.8-1.81.8
Intraocular pressure0.60.91.30.9-0.9-0.90.90.9-0.90.90.90.91.0-0.9-0.9-0.9-1.10.9
Delta distance traveled before/after self-admin2.72.93.3-1.71.81.8-1.7-1.71.7-1.7-1.7-1.7-1.71.51.51.51.7-1.7
Delta ambulatory time before/after self-admin2.42.63.1-1.71.81.8-1.7-1.71.7-1.7-1.7-1.7-1.71.31.31.31.6-1.7
Parametrial fat weight3.97.68.92.7-2.7-2.72.72.7-2.72.72.72.72.7-3.0-3.0-3.0-2.62.7
Pavlov. Cond. lever latency0.00.00.00.00.20.20.00.0-0.00.00.00.00.1-0.2-0.2-0.2-0.20.0
Pavlov. Cond. magazine entry latency0.10.10.20.3-0.2-0.20.30.3-0.30.30.30.30.3-0.4-0.4-0.4-0.40.3
Pavlov. Cond. change in total contacts1.11.21.5-1.11.01.0-1.1-1.11.1-1.1-1.1-1.1-1.11.11.11.11.2-1.1
Pavlov. Cond. index score0.10.10.2-0.30.20.2-0.3-0.30.3-0.3-0.3-0.3-0.30.40.40.40.3-0.3
Pavlov. Cond. latency score0.00.00.1-0.10.10.1-0.1-0.10.1-0.1-0.1-0.1-0.10.20.20.20.2-0.1
Pavlov. Cond. lever contacts0.00.00.0-0.0-0.2-0.2-0.0-0.00.0-0.0-0.00.0-0.00.10.10.10.2-0.0
Pavlov. Cond. magazine entry number0.30.40.60.7-0.8-0.80.70.6-0.60.60.70.70.6-0.5-0.5-0.5-0.50.6
Pavlov. Cond. intertrial magazine entries0.10.10.20.3-0.4-0.40.30.3-0.30.30.30.30.3-0.4-0.4-0.4-0.40.3
Pavlov. Cond. lever-magazine prob. diff.0.20.20.3-0.40.30.3-0.4-0.40.4-0.4-0.4-0.4-0.40.50.50.50.5-0.4
Pavlov. Cond. response bias0.10.10.1-0.40.30.3-0.4-0.40.4-0.4-0.4-0.4-0.40.30.30.30.4-0.4
Pavlov. Cond. lever latency0.50.71.30.7-0.7-0.70.70.7-0.70.70.70.70.7-1.1-1.1-1.1-0.80.7
Pavlov. Cond. magazine entry latency0.00.10.10.3-0.2-0.20.30.3-0.30.30.30.30.30.00.00.0-0.30.3
Pavlov. Cond. change in total contacts1.72.33.0-1.51.51.5-1.5-1.51.5-1.5-1.5-1.5-1.51.71.71.71.4-1.5
Pavlov. Cond. index score0.60.71.2-0.80.80.8-0.8-0.80.8-0.8-0.8-0.8-0.81.11.11.10.7-0.8
Pavlov. Cond. latency score0.40.40.8-0.60.60.6-0.6-0.60.6-0.6-0.6-0.6-0.60.90.90.90.5-0.6
Pavlov. Cond. lever contacts0.50.71.2-0.70.70.7-0.7-0.70.7-0.7-0.7-0.7-0.71.11.11.10.7-0.7
Pavlov. Cond. magazine entry number0.00.00.1-0.20.20.2-0.2-0.20.2-0.2-0.2-0.2-0.2-0.1-0.1-0.10.2-0.2
Pavlov. Cond. intertrial magazine entries6.58.48.82.9-2.8-2.82.92.9-2.92.92.92.92.9-3.0-3.0-3.0-2.92.9
Pavlov. Cond. lever-magazine prob. diff.0.70.81.3-0.90.90.9-0.9-0.80.8-0.8-0.8-0.8-0.81.11.11.10.8-0.8
Pavlov. Cond. response bias0.60.81.5-0.80.80.8-0.8-0.80.8-0.8-0.8-0.8-0.81.21.21.20.9-0.8
Time in closed arm before self-admin1.31.51.8-1.21.31.3-1.2-1.21.2-1.2-1.2-1.2-1.21.01.01.01.3-1.2
Time in closed arm after self-admin0.50.50.7-0.70.70.7-0.7-0.70.7-0.7-0.7-0.7-0.80.70.70.70.9-0.7
Time in open arm before self-admin0.20.20.2-0.50.30.3-0.5-0.50.5-0.5-0.5-0.5-0.50.20.20.20.5-0.5
Time in open arm after self-admin0.10.10.20.2-0.2-0.20.20.3-0.30.30.20.20.3-0.4-0.4-0.4-0.40.3
Bone: periosteal estimation0.00.00.0-0.10.10.1-0.1-0.00.0-0.1-0.1-0.10.00.00.00.0-0.2-0.0
Bone: periosteal perimeter0.00.00.0-0.00.00.0-0.00.0-0.0-0.0-0.0-0.00.00.10.10.1-0.10.0
Bone: post-yield work0.20.30.40.5-0.5-0.50.50.5-0.50.50.50.50.5-0.6-0.6-0.6-0.60.5
Progressive ratio test 1 active lever presses0.10.20.3-0.40.50.5-0.4-0.40.4-0.4-0.4-0.4-0.40.20.20.20.5-0.4
Progressive ratio test 1 breakpoint0.10.10.1-0.20.30.3-0.2-0.20.2-0.2-0.2-0.2-0.30.00.00.00.3-0.2
Progressive ratio test 1 inactive lever presses1.61.81.81.3-1.3-1.31.31.3-1.31.31.31.31.3-1.3-1.3-1.3-1.31.3
Progressive ratio test 2 active lever presses0.30.30.90.4-0.5-0.50.50.4-0.40.40.40.40.4-0.9-0.9-0.9-0.40.4
Progressive ratio test 2 breakpoint0.30.41.20.4-0.5-0.50.40.4-0.40.40.40.40.4-1.1-1.1-1.1-0.40.4
Progressive ratio test 2 inactive lever presses0.40.50.90.6-0.7-0.70.60.6-0.60.60.60.60.6-0.9-0.9-0.9-0.60.6
Incentive Sensitization - Responses1.11.11.90.9-1.0-1.00.90.9-0.90.90.90.90.9-1.4-1.4-1.4-0.90.9
Incentive Sensitization - Breakpoint1.41.52.31.1-1.2-1.21.11.1-1.11.11.11.11.1-1.5-1.5-1.5-1.11.1
Sum of active levers in priming session hrs 5-60.10.10.40.00.00.00.00.0-0.00.00.00.00.1-0.7-0.7-0.7-0.10.1
Progressive ratio0.00.00.10.1-0.3-0.30.10.1-0.10.10.10.20.10.30.30.30.00.1
Food seeking constrained by brief footshock1.21.51.6-1.31.31.3-1.3-1.31.3-1.3-1.3-1.3-1.21.01.01.01.1-1.2
Seeking ratio, punishment vs. effort0.50.61.0-0.91.01.0-0.9-0.80.8-0.8-0.8-0.9-0.80.20.20.20.5-0.8
Retroperitoneal fat weight0.20.81.00.9-0.7-0.70.90.9-0.90.90.90.90.9-1.0-1.0-1.0-1.00.9
Reaction time number correct0.40.60.8-0.80.90.9-0.8-0.80.8-0.8-0.8-0.8-0.70.50.50.50.5-0.8
Reaction time mean minus median0.30.40.6-0.60.70.7-0.6-0.60.6-0.6-0.6-0.6-0.60.50.50.50.6-0.6
Reaction time mean minus median AUC0.30.30.4-0.60.70.7-0.6-0.60.6-0.6-0.6-0.6-0.60.50.50.50.6-0.6
Reaction time num false alarms0.00.00.2-0.00.20.2-0.0-0.00.0-0.0-0.0-0.00.0-0.4-0.4-0.4-0.30.0
Reaction time num false alarms AUC0.10.10.20.1-0.0-0.00.10.2-0.20.20.20.10.2-0.5-0.5-0.5-0.40.2
Reaction time trials correct on left0.40.60.8-0.80.90.9-0.8-0.80.8-0.8-0.8-0.8-0.70.50.50.50.5-0.8
Reaction time trials on left0.30.40.6-0.70.80.8-0.7-0.70.7-0.7-0.7-0.7-0.60.40.40.40.4-0.6
Reaction time mean0.30.40.5-0.60.70.7-0.6-0.60.6-0.6-0.6-0.6-0.60.60.60.60.6-0.6
Reaction time mean AUC0.50.70.8-0.80.90.9-0.8-0.80.8-0.8-0.8-0.8-0.80.90.90.90.9-0.8
Median of all reaction times0.10.10.2-0.30.30.3-0.3-0.30.3-0.3-0.3-0.3-0.30.40.40.40.4-0.3
Reaction time omissions2.33.13.31.8-1.8-1.81.81.8-1.81.81.81.81.8-1.6-1.6-1.6-1.81.8
Reaction time false alarm rate0.20.30.50.5-0.5-0.50.50.5-0.50.50.50.50.5-0.7-0.7-0.7-0.60.5
Reaction time premature initiation rate1.31.72.1-1.31.51.5-1.3-1.31.3-1.3-1.3-1.3-1.31.11.11.11.3-1.3
Reaction time premature initiations1.82.53.3-1.61.81.8-1.6-1.61.6-1.6-1.6-1.7-1.61.31.31.31.5-1.6
Std. dev. reaction times0.30.40.6-0.60.80.8-0.6-0.60.6-0.6-0.6-0.6-0.60.50.50.50.6-0.6
Reaction time trials completed0.30.40.6-0.70.80.8-0.7-0.70.7-0.7-0.7-0.7-0.60.40.40.40.4-0.6
Reaction time trials AUC0.20.30.6-0.60.70.7-0.6-0.60.6-0.6-0.6-0.7-0.60.30.30.30.4-0.6
Run reversals in cocaine runway, females3.83.74.12.0-1.8-1.82.02.0-2.02.02.02.02.0-1.7-1.7-1.7-2.02.0
Run reversals in cocaine runway, males2.42.32.4-1.51.51.5-1.5-1.51.5-1.5-1.5-1.5-1.51.51.51.51.4-1.5
Latency to leave start box in cocaine runway1.21.22.9-0.90.70.7-0.9-0.90.9-0.9-0.9-0.9-1.01.71.71.71.1-1.0
Latency to leave start box in cocaine runway, F2.42.65.1-1.41.21.2-1.4-1.41.4-1.4-1.4-1.4-1.52.32.32.31.8-1.5
Latency to leave start box in cocaine runway, M1.31.21.61.1-1.1-1.11.11.1-1.11.11.11.11.2-0.9-0.9-0.9-1.31.1
Std. dev. time between licks in bursts1.92.33.11.4-1.3-1.31.41.5-1.51.41.41.41.5-1.8-1.8-1.8-1.61.5
Total sessions with >9 infusions0.10.10.20.1-0.1-0.10.10.1-0.10.10.10.10.1-0.5-0.5-0.5-0.10.1
Short access day 1 total inactive lever presses0.70.71.30.8-0.8-0.80.80.8-0.80.80.80.80.8-1.1-1.1-1.1-0.70.8
Short access day 10 total inactive lever presses0.30.40.40.7-0.6-0.60.70.7-0.70.70.70.70.7-0.3-0.3-0.3-0.70.6
Short access day 1 total infusions0.10.10.3-0.40.30.3-0.4-0.40.4-0.4-0.4-0.3-0.40.20.20.20.6-0.4
Short access day 10 total infusions0.00.00.00.2-0.2-0.20.20.2-0.20.20.20.20.2-0.1-0.1-0.1-0.10.2
Short access total infusions0.20.20.40.5-0.5-0.50.50.5-0.50.50.50.50.4-0.6-0.6-0.6-0.30.5
Short access day 1 locomotion0.30.30.5-0.50.50.5-0.5-0.50.5-0.5-0.5-0.5-0.60.60.60.60.7-0.5
Short access day 10 total locomotion0.60.60.80.9-0.8-0.80.90.9-0.90.90.90.90.9-0.5-0.5-0.5-0.70.8
Short access total locomotion0.70.70.90.9-0.9-0.90.90.9-0.90.90.90.90.9-0.6-0.6-0.6-0.80.9
One hour access (0.3 mA shock)0.20.30.30.5-0.5-0.50.50.5-0.50.50.50.50.5-0.6-0.6-0.6-0.50.5
Compulsive drug intake0.00.00.1-0.10.10.1-0.1-0.10.2-0.1-0.1-0.1-0.20.30.30.30.3-0.2
One hour access (shock baseline)0.00.00.00.00.00.00.00.0-0.00.00.00.00.00.00.00.0-0.00.0
Social response proportion0.10.20.3-0.40.30.3-0.4-0.40.4-0.4-0.4-0.4-0.40.30.30.30.6-0.4
Social responses1.31.72.01.3-1.2-1.21.31.3-1.31.31.31.31.3-1.4-1.4-1.4-1.41.3
Social time0.20.20.50.5-0.7-0.70.50.5-0.50.50.50.50.4-0.2-0.2-0.2-0.30.5
Soleus weight0.92.62.6-1.61.61.6-1.6-1.61.6-1.6-1.6-1.6-1.61.61.61.61.5-1.6
Bone: stiffness0.40.70.8-0.90.90.9-0.9-0.80.8-0.8-0.8-0.9-0.80.70.70.70.6-0.8
Tibialis anterior weight8.328.328.7-5.45.15.1-5.4-5.45.3-5.4-5.3-5.3-5.45.35.35.35.3-5.3
Time to tail flick, vehicle, before self-admin1.01.01.60.9-0.9-0.90.90.9-0.90.90.90.91.0-1.3-1.3-1.3-1.01.0
Time to tail flick, vehicle, after self-admin2.22.43.3-1.41.61.6-1.4-1.41.4-1.4-1.4-1.4-1.41.81.81.81.6-1.4
Time to tail flick, test, before self-admin1.11.11.51.0-0.9-0.91.01.0-1.01.01.01.01.1-1.2-1.2-1.2-1.21.0
Time to tail flick, test, after self-admin3.23.33.51.9-1.8-1.81.91.9-1.91.91.91.91.8-1.8-1.8-1.8-1.71.8
Delta time to tail flick, vehicle, before/after SA0.70.71.7-0.70.70.7-0.7-0.70.7-0.7-0.7-0.7-0.71.31.31.30.9-0.7
Delta time to tail flick, test, before/after SA0.20.20.30.5-0.5-0.50.50.5-0.50.50.50.50.4-0.3-0.3-0.3-0.20.4
Tibia length1.13.13.41.8-1.8-1.81.81.8-1.81.81.81.81.7-1.8-1.8-1.8-1.71.7
Ambulatory time before self-admin0.40.40.5-0.60.70.7-0.6-0.60.6-0.6-0.6-0.6-0.60.50.50.50.6-0.6
Ambulatory time after self-admin3.64.04.9-2.12.22.2-2.1-2.12.1-2.1-2.1-2.1-2.11.61.61.62.1-2.1
Bone: tissue strength0.20.20.20.4-0.5-0.50.40.4-0.40.40.40.40.4-0.5-0.5-0.5-0.40.4
Total heroin consumption0.30.30.6-0.60.70.7-0.6-0.60.6-0.6-0.6-0.6-0.60.40.40.40.5-0.6
Bone: trabecular number2.84.44.52.1-2.0-2.02.12.1-2.12.12.12.12.1-2.1-2.1-2.1-2.12.1
Bone: trabecular spacing2.53.33.5-1.81.81.8-1.8-1.81.8-1.8-1.8-1.8-1.81.91.91.91.8-1.8
Bone: trabecular thickness1.31.61.81.2-1.3-1.31.21.2-1.21.21.21.21.2-1.3-1.3-1.3-1.31.2
Bone: trabecular tissue density1.31.82.3-1.41.51.5-1.4-1.41.4-1.4-1.4-1.4-1.41.11.11.11.3-1.4
Water consumed over 24 hours0.91.11.6-1.11.31.3-1.1-1.11.1-1.1-1.1-1.1-1.00.90.90.90.8-1.0
Number of responses in last shaping day0.00.00.0-0.10.00.0-0.1-0.10.1-0.1-0.1-0.1-0.10.10.10.10.2-0.1