Hub : Genes

LOC120103113

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression LOC120103113 0.17 0.14 7.5e-12 0.08 0.08 0.08 0.08 4.3e-09 8.8e-09 7.4e-09 8.1e-09
2 Brain gene expression LOC120103113 0.03 0.03 1.9e-03 0.02 0.01 0.02 0.01 3.9e-03 1.7e-02 8.4e-03 1.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.10.20.20.4-0.5
Area under the delay curve1.31.41.51.1-1.2
BMI with tail0.10.40.5-0.60.7
BMI without tail0.20.50.6-0.70.7
Body weight0.10.30.40.7-0.5
Weight adjusted by age2.73.13.1-1.71.8
Bone surface1.72.93.0-1.71.7
Bone volume0.50.80.9-0.90.9
Breakpoint value in progressive ratio session2.12.32.41.5-1.5
Number of licking bursts0.00.00.00.2-0.1
Context. condit. distance diff. score2.53.03.01.7-1.7
Locomotion velocity, session 10.10.10.1-0.20.3
Locomotion distance, session 10.81.01.11.1-0.9
Locomotion velocity, session 20.40.40.5-0.60.7
Locomotion distance, session 20.00.00.0-0.10.2
Locomotion velocity, session 30.00.00.00.1-0.0
Locomotion distance, session 30.00.00.0-0.0-0.0
Stereotopy head waving bouts, day 31.01.21.21.1-1.0
Stereotopy head waving duration, day 30.91.01.11.0-1.0
Locomotion velocity, session 70.70.80.91.0-0.8
Locomotion distance, session 70.20.20.20.5-0.4
Stereotopy head waving bouts, day 70.70.80.9-0.90.9
Stereotopy head waving duration, day 70.50.60.6-0.80.8
Locomotion velocity, session 80.40.50.60.8-0.7
Locomotion distance, session 80.91.31.31.1-1.1
Degree of sensitization distance0.10.10.1-0.30.3
Degree of sensitization stereotypy1.11.21.3-1.11.0
Conditioned locomotion0.00.00.00.1-0.0
Cocaine response after cond. corrected0.40.50.5-0.70.7
Cocaine response after cond. not corrected0.30.40.4-0.50.7
Cocaine response before conditioning0.00.00.00.1-0.1
Saline control response0.00.00.0-0.10.0
Bone: connectivity density1.72.72.8-1.71.6
Bone: cortical apparent density7.59.810.13.1-3.2
Bone: cortical area0.10.20.2-0.50.4
Bone: cortical porosity0.40.50.5-0.70.7
Bone: cortical porosity0.60.70.7-0.90.8
Bone: cortical thickness0.20.30.40.5-0.6
Bone: cortical thickness0.00.00.1-0.30.2
Bone: cortical tissue density7.29.59.83.0-3.1
Condit. Reinf. active minus inactive responses0.00.00.00.0-0.1
Condit. Reinf. active-inactive response ratio0.00.00.10.2-0.3
Condit. Reinf. active responses0.10.20.2-0.40.4
Condit. Reinf. inactive responses0.20.30.3-0.50.6
Incentive salience index mean0.00.00.0-0.00.0
Condit. Reinf. lever presses0.20.30.30.5-0.6
Condit. Reinf. active minus inactive responses0.60.70.70.8-0.8
Condit. Reinf. active-inactive response ratio0.00.00.00.2-0.2
Condit. Reinf. active responses0.60.80.90.9-0.9
Condit. Reinf. inactive responses1.92.32.51.6-1.5
Condit. Reinf. lever presses2.94.04.0-2.02.0
Condit. Reinf. lever reinforcers received0.10.20.20.5-0.4
Conditioned reinforcement - actives0.60.60.60.8-0.8
Conditioned reinforcement - inactives1.61.81.81.3-1.4
Conditioned locomotion0.30.30.30.6-0.6
Patch foraging indifference point 0 sec5.79.19.4-3.13.0
Patch foraging indifference point AUC0.50.60.6-0.70.8
Delay disc. indifference point, 0s delay2.42.72.81.6-1.7
Delay disc. indifference point, 16s delay0.10.10.1-0.30.2
Delay disc. indifference point, 2s delay0.80.91.10.8-1.1
Delay disc. indifference point, 24s delay0.30.20.30.5-0.5
Delay disc. indifference point, 4s delay4.34.54.92.1-2.2
Delay disc. indifference point, 8s delay2.93.03.11.7-1.8
Indifference point function ln k0.10.20.20.3-0.5
Indifference point function log k0.10.20.20.3-0.5
Patch foraging total patch changes 0 sec5.08.18.3-2.92.8
Patch foraging total patch changes 12 sec0.40.50.6-0.70.8
Patch foraging total patch changes 18 sec1.62.02.1-1.41.4
Patch foraging total patch changes 24 sec1.01.31.3-1.11.2
Patch foraging total patch changes 6 sec1.72.52.6-1.61.6
Patch foraging time to switch 0 sec2.33.63.71.9-1.9
Patch foraging water rate 0 sec1.52.42.4-1.61.6
Patch foraging water rate 12 sec3.24.95.2-2.32.1
Patch foraging water rate 18 sec0.10.10.2-0.40.3
Patch foraging water rate 24 sec0.00.10.10.1-0.3
Patch foraging water rate 6 sec0.20.30.3-0.50.6
Seeking ratio, delayed vs. immediate footshock0.00.00.00.1-0.1
Distance traveled before self-admin0.40.40.50.6-0.7
Distance traveled after self-admin0.20.20.20.4-0.5
Extensor digitorum longus weight0.62.22.41.6-1.4
Bone: elastic displacement0.40.40.50.6-0.7
Bone: elastic work0.91.11.31.0-1.2
Bone: endosteal estimation0.51.11.1-1.01.1
Bone: endosteal perimeter1.12.32.3-1.51.5
Epididymis fat weight2.25.25.82.4-2.1
Delta time in closed arm before/after self-admin0.40.40.4-0.70.5
Delta time in open arm before/after self-admin0.90.91.0-0.91.0
Diff in mean of infusions in LGA sessions0.80.91.00.9-1.0
Delay discount exponential model param1.31.41.5-1.11.2
Extinction: sum of active levers before priming0.90.90.91.0-1.0
Active lever presses in extinction session 60.30.30.40.4-0.6
Bone: final force0.50.80.90.9-1.0
Bone: final moment0.00.00.10.1-0.2
Food consumed during 24 hour testing period0.81.01.01.0-1.0
Glucose0.50.80.9-0.90.9
Heart weight2.13.03.11.7-1.8
Delay discount hyperbolic model param1.51.61.8-1.21.4
Intermittent access intake day 1-15 change1.21.11.21.0-1.1
Intermittent access intake escalation1.21.21.21.1-1.1
Intermittent access intake escalation 21.01.01.01.0-1.0
Intermitt. access day 1 inactive lever presses1.92.02.1-1.41.4
Intermitt. access day 15 inactive lever presses0.50.60.60.8-0.7
Intermitt. access escalation Index2.11.82.0-1.31.4
Intermittent access day 1 total infusions0.00.00.00.2-0.2
Intermittent access day 15 total infusions0.40.50.50.7-0.7
Intermittent access terminal intake (last 3 days)0.20.20.20.4-0.4
Intermittent access total infusions0.10.10.10.4-0.4
Intermittent access day 1 locomotion0.40.50.5-0.70.7
Intermittent access day 15 total locomotion0.00.10.1-0.30.2
Intermittent access total locomotion0.20.30.3-0.60.5
Intermittent access standard deviation1.01.01.01.0-1.0
Left kidney weight0.51.51.61.3-1.2
Right kidney weight0.51.31.51.2-1.1
Cocaine induced anxiety0.00.00.00.0-0.1
Post-drug Anxiety1.11.21.31.1-1.1
Baseline Anxiety0.40.40.50.7-0.6
Tail length0.92.83.01.6-1.7
Length with tail0.62.22.21.5-1.5
Length without tail0.10.10.20.4-0.2
Times rat made contact with spout0.00.00.0-0.20.0
Lifetime Intake0.00.00.00.1-0.1
Liver weight, left1.62.52.61.6-1.6
Liver weight, right5.89.610.13.2-3.0
Locomotor activity0.00.00.0-0.10.1
Locomotor testing distance1.32.12.1-1.41.5
Locomotor testing rearing0.00.00.00.2-0.2
Locomotion in novel chamber1.21.51.6-1.11.3
Locomotion in novel chamber post-restriction0.00.00.0-0.2-0.2
Fecal boli incidents, locomotor time 10.10.10.1-0.30.3
Change in fecal boli incidents, locomotor task0.10.10.10.4-0.3
Time >=10cm from walls, locomotor time 10.20.20.2-0.40.5
Bouts of movement, locomotor time 10.10.10.1-0.20.3
Total resting periods, locomotor time 10.00.10.1-0.20.3
Rest time, locomotor task time 10.00.00.00.0-0.0
Distance moved, locomotor task time 10.00.00.00.1-0.2
Vertical activity count, locomotor time 10.00.00.0-0.20.1
Time >=10cm from walls, locomotor time 22.02.12.21.4-1.5
Bouts of movement, locomotor time 20.80.81.0-1.00.8
Total resting periods, locomotor time 21.01.11.2-1.11.0
Rest time, locomotor task time 20.70.80.9-0.81.0
Distance moved, locomotor task time 21.41.61.81.2-1.3
Vertical activity count, locomotor time 20.50.60.70.6-0.9
Light reinforcement 10.50.91.00.9-1.0
Light reinforcement 20.30.50.60.6-0.8
Bone: marrow area0.51.01.0-1.01.0
Bone: maximum diameter0.40.80.9-0.90.8
Bone: maximum force0.20.30.40.5-0.6
Bone: maximum moment0.00.10.1-0.30.2
Mean time between licks in bursts6.38.99.13.0-2.9
Mean num. licks in bursts0.10.10.2-0.40.3
Cd content in liver1.51.71.7-1.31.3
Co content in liver0.10.10.10.4-0.4
Cu content in liver0.40.40.50.6-0.7
Fe content in liver0.91.11.1-1.11.0
K content in liver1.31.21.41.1-1.2
Mg content in liver0.30.30.3-0.60.4
Mn content in liver0.10.10.10.4-0.2
Na content in liver3.33.53.61.9-1.8
Rb content in liver0.81.01.11.0-1.1
Se content in liver0.81.01.1-1.11.0
Sr content in liver0.00.00.1-0.20.1
Zn content in liver1.01.11.2-1.11.0
Bone: minimum diameter1.42.62.7-1.61.6
Time in familiar zone, hab. session 12.82.62.71.6-1.6
Time in novel zone, hab. session 17.16.97.2-2.62.7
Total zone transitions, hab. session 12.43.43.51.9-1.8
Total locomotion distance, hab. session 10.30.40.40.7-0.5
Locomotion velocity, hab. session 10.30.40.50.7-0.6
Time in familiar zone, hab. session 20.60.60.70.8-0.8
Time in novel zone, hab. session 21.31.31.4-1.11.2
Total zone transitions, hab. session 25.47.07.42.7-2.6
Total locomotion distance, hab. session 22.33.13.41.9-1.6
Locomotion velocity, hab. session 22.02.83.11.8-1.6
Novel to familiar place preference ratio1.81.92.0-1.41.3
Novelty place preference1.41.51.5-1.21.2
Time in novel zone, NPP test2.02.12.2-1.51.4
Total zone transitions, NPP test2.13.13.11.8-1.7
Total locomotion distance, NPP test0.30.40.50.7-0.6
Locomotion velocity, NPP test0.60.80.90.9-0.8
Intraocular pressure0.10.10.2-0.40.4
Delta distance traveled before/after self-admin0.30.30.4-0.50.7
Delta ambulatory time before/after self-admin0.10.10.1-0.20.3
Parametrial fat weight5.510.810.8-3.33.3
Pavlov. Cond. lever latency0.20.20.30.5-0.4
Pavlov. Cond. magazine entry latency0.50.70.70.8-0.8
Pavlov. Cond. change in total contacts0.40.40.4-0.70.6
Pavlov. Cond. index score0.00.00.0-0.0-0.1
Pavlov. Cond. latency score0.00.00.0-0.10.0
Pavlov. Cond. lever contacts0.00.00.00.0-0.1
Pavlov. Cond. magazine entry number0.70.80.9-0.90.9
Pavlov. Cond. intertrial magazine entries0.50.70.80.9-0.7
Pavlov. Cond. lever-magazine prob. diff.0.00.00.0-0.0-0.0
Pavlov. Cond. response bias0.40.40.50.6-0.7
Pavlov. Cond. lever latency1.62.12.21.5-1.4
Pavlov. Cond. magazine entry latency1.61.82.0-1.41.3
Pavlov. Cond. change in total contacts2.12.82.9-1.71.7
Pavlov. Cond. index score1.82.32.4-1.61.5
Pavlov. Cond. latency score1.41.81.9-1.41.3
Pavlov. Cond. lever contacts2.23.03.1-1.71.7
Pavlov. Cond. magazine entry number0.60.70.70.9-0.8
Pavlov. Cond. intertrial magazine entries1.01.31.41.2-1.1
Pavlov. Cond. lever-magazine prob. diff.1.72.22.3-1.51.4
Pavlov. Cond. response bias1.82.52.5-1.61.6
Time in closed arm before self-admin0.10.10.20.4-0.4
Time in closed arm after self-admin0.10.10.1-0.40.2
Time in open arm before self-admin0.00.00.00.1-0.1
Time in open arm after self-admin1.41.51.5-1.21.2
Bone: periosteal estimation0.51.11.1-1.11.0
Bone: periosteal perimeter0.50.80.8-0.90.9
Bone: post-yield work1.21.61.6-1.31.3
Progressive ratio test 1 active lever presses3.33.53.61.8-1.9
Progressive ratio test 1 breakpoint4.64.84.92.2-2.2
Progressive ratio test 1 inactive lever presses1.41.51.71.1-1.3
Progressive ratio test 2 active lever presses0.30.30.30.6-0.6
Progressive ratio test 2 breakpoint0.30.30.30.6-0.5
Progressive ratio test 2 inactive lever presses0.40.40.40.7-0.6
Incentive Sensitization - Responses0.10.10.2-0.30.4
Incentive Sensitization - Breakpoint0.10.10.2-0.40.4
Sum of active levers in priming session hrs 5-64.14.04.12.0-2.0
Progressive ratio0.30.30.40.5-0.6
Food seeking constrained by brief footshock3.64.44.62.1-2.1
Seeking ratio, punishment vs. effort0.60.70.90.9-0.7
Retroperitoneal fat weight0.30.81.01.0-0.8
Reaction time number correct0.00.00.00.1-0.1
Reaction time mean minus median0.10.10.1-0.20.4
Reaction time mean minus median AUC0.00.00.10.2-0.1
Reaction time num false alarms0.20.30.3-0.50.6
Reaction time num false alarms AUC0.71.01.1-1.01.0
Reaction time trials correct on left0.00.00.00.1-0.1
Reaction time trials on left0.00.00.0-0.00.0
Reaction time mean0.71.01.2-1.01.1
Reaction time mean AUC0.30.40.5-0.60.7
Median of all reaction times1.01.41.5-1.11.2
Reaction time omissions1.62.12.4-1.41.5
Reaction time false alarm rate0.91.31.4-1.11.2
Reaction time premature initiation rate0.50.70.80.7-0.9
Reaction time premature initiations0.71.01.20.9-1.1
Std. dev. reaction times1.21.71.9-1.21.4
Reaction time trials completed0.00.00.0-0.00.0
Reaction time trials AUC0.00.00.0-0.00.1
Run reversals in cocaine runway, females0.00.00.0-0.00.1
Run reversals in cocaine runway, males0.30.20.3-0.50.4
Latency to leave start box in cocaine runway0.20.20.20.5-0.5
Latency to leave start box in cocaine runway, F0.10.10.10.2-0.3
Latency to leave start box in cocaine runway, M0.20.20.20.5-0.3
Std. dev. time between licks in bursts0.00.00.00.1-0.0
Total sessions with >9 infusions1.51.61.71.2-1.3
Short access day 1 total inactive lever presses0.20.20.2-0.50.4
Short access day 10 total inactive lever presses2.12.32.3-1.51.5
Short access day 1 total infusions0.10.10.1-0.30.3
Short access day 10 total infusions0.20.20.20.5-0.4
Short access total infusions0.00.00.0-0.10.1
Short access day 1 locomotion0.60.60.6-0.80.8
Short access day 10 total locomotion0.40.40.5-0.70.6
Short access total locomotion0.00.00.00.1-0.2
One hour access (0.3 mA shock)0.00.00.00.1-0.1
Compulsive drug intake7.07.17.2-2.72.7
One hour access (shock baseline)3.23.73.82.0-1.9
Social response proportion1.51.61.6-1.31.2
Social responses0.10.10.10.3-0.4
Social time0.50.60.7-0.80.8
Soleus weight0.20.40.50.7-0.6
Bone: stiffness0.20.40.40.6-0.6
Tibialis anterior weight7.927.127.5-5.25.2
Time to tail flick, vehicle, before self-admin1.11.11.3-1.11.0
Time to tail flick, vehicle, after self-admin1.31.41.5-1.21.2
Time to tail flick, test, before self-admin0.20.20.2-0.50.3
Time to tail flick, test, after self-admin0.00.00.0-0.00.0
Delta time to tail flick, vehicle, before/after SA0.20.20.20.5-0.4
Delta time to tail flick, test, before/after SA0.10.10.1-0.20.3
Tibia length2.87.98.42.7-2.9
Ambulatory time before self-admin0.80.91.00.8-1.0
Ambulatory time after self-admin0.10.10.10.3-0.4
Bone: tissue strength0.30.30.4-0.60.5
Total heroin consumption1.31.51.61.2-1.3
Bone: trabecular number0.00.00.00.2-0.2
Bone: trabecular spacing0.00.00.00.1-0.2
Bone: trabecular thickness0.00.00.00.1-0.1
Bone: trabecular tissue density15.621.922.04.7-4.7
Water consumed over 24 hours0.00.00.0-0.20.1
Number of responses in last shaping day0.30.40.50.7-0.5