Best TWAS P=7.42e-10 · Best GWAS P=3.91e-10 conditioned to 1.18e-01
Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
---|---|---|---|---|---|---|---|---|---|---|---|
Adipose | Rasgrp3 | isoform ratio | XM_006239762.4 | 0.05 | 1 | 0.04 | 8.2e-05 | -6.16 | 7.42e-10 | 0.37 | TRUE |
Adipose | Rasgrp3 | intron excision ratio | chr6_19968222_19993572 | 0.04 | 22 | 0.01 | 2.2e-02 | -5.26 | 1.47e-07 | 0.42 | FALSE |
BLA | Ltbp1 | gene expression | Ltbp1 | 0.19 | 2413 | 0.17 | 3.2e-09 | -5.26 | 1.43e-07 | 0.59 | FALSE |
BLA | Rasgrp3 | isoform ratio | NM_001399544.1 | 0.07 | 10 | 0.03 | 1.7e-02 | -5.55 | 2.85e-08 | 0.51 | FALSE |
BLA | Rasgrp3 | intron excision ratio | chr6_19935344_19993572 | 0.15 | 1 | 0.08 | 5.9e-05 | -5.19 | 2.12e-07 | 0.04 | FALSE |
Brain | Ltbp1 | gene expression | Ltbp1 | 0.53 | 149 | 0.43 | 9.4e-43 | 5.19 | 2.13e-07 | 0.83 | FALSE |
IL | Ltbp1 | gene expression | Ltbp1 | 0.32 | 39 | 0.24 | 2.3e-06 | -6.06 | 1.38e-09 | 0.72 | FALSE |
OFC | Ltbp1 | gene expression | Ltbp1 | 0.2 | 2413 | 0.13 | 6.0e-04 | -5.78 | 7.67e-09 | 0.64 | FALSE |
PL | Rasgrp3 | isoform ratio | XM_006239759.4 | 0.04 | 26 | 0.02 | 1.5e-03 | -5.77 | 7.76e-09 | 0.65 | FALSE |
PL | Rasgrp3 | intron excision ratio | chr6_19935344_19958446 | 0.03 | 2404 | 0.01 | 6.8e-02 | -5.75 | 8.90e-09 | 0.6 | FALSE |
PL | Rasgrp3 | mRNA stability | Rasgrp3 | 0.05 | 1 | 0.05 | 7.1e-06 | -5.5 | 3.70e-08 | 0.08 | FALSE |
pVTA | Fam98a | gene expression | Fam98a | 0.09 | 66 | 0.08 | 1.7e-04 | -5.4 | 6.63e-08 | 0.32 | FALSE |
pVTA | Ltbp1 | gene expression | Ltbp1 | 0.25 | 6 | 0.22 | 9.3e-10 | -5.9 | 3.63e-09 | 0.82 | FALSE |