Hub : Genes

Cdca5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL alternative polyA XM_008760176.3 0.05 0.03 2.5e-05 0.05 0.04 0.04 0.04 6.6e-06 1.0e-05 2.0e-05 1.2e-05
2 NAcc alternative polyA XM_008760176.3 0.05 0.03 1.4e-07 0.03 0.05 0.05 0.05 2.1e-05 9.9e-08 4.9e-08 1.3e-07
3 pVTA alternative polyA NM_001115042.2 0.03 0.02 5.7e-03 0.01 0.02 0.02 0.01 2.7e-02 5.0e-03 1.2e-02 2.6e-02
4 pVTA alternative polyA XM_008760176.3 0.04 0.02 5.3e-03 0.01 0.02 0.02 0.01 4.2e-02 4.9e-03 1.3e-02 2.8e-02
5 IC alternative polyA XM_008760176.3 0.13 0.08 1.1e-03 0.03 0.03 0.01 0.02 2.5e-02 2.3e-02 8.5e-02 3.9e-02
6 RMTg alternative TSS NM_001115042.2 0.13 0.08 9.2e-03 0.16 0.09 0.13 0.15 5.1e-05 2.5e-03 2.5e-04 8.1e-05
7 RMTg alternative TSS XM_008760177.4 0.12 0.08 9.4e-03 0.17 0.08 0.14 0.16 3.7e-05 3.5e-03 1.2e-04 5.9e-05
8 OFC alternative TSS NM_001115042.2 0.24 0.21 4.7e-03 0 0.01 0.05 -0.01 2.4e-01 1.9e-01 3.0e-02 6.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.11.83.0-0.9-1.71.5-1.6-1.71.3-1.3-0.3
Area under the delay curve0.30.30.90.0-0.40.4-0.5-0.90.5-0.50.9
BMI with tail3.110.821.4-2.3-4.24.0-4.2-4.61.9-1.9-1.1
BMI without tail1.33.99.9-1.6-2.22.5-2.7-3.10.4-0.4-0.6
Body weight2.711.819.4-3.8-3.94.4-4.4-4.1-0.10.1-3.2
Weight adjusted by age0.91.42.6-1.5-1.21.2-1.1-0.4-1.11.1-1.6
Bone surface3.87.014.8-3.1-3.93.3-3.4-2.50.7-0.7-1.4
Bone volume1.93.48.2-1.8-2.92.2-2.2-1.71.2-1.2-0.3
Breakpoint value in progressive ratio session2.12.64.9-2.0-2.22.0-2.0-1.3-0.70.7-1.0
Number of licking bursts0.10.20.5-0.6-0.70.6-0.6-0.3-0.10.1-0.2
Context. condit. distance diff. score1.11.42.61.61.4-1.31.30.61.0-1.01.0
Locomotion velocity, session 10.20.20.5-0.10.60.00.0-0.2-0.50.5-0.7
Locomotion distance, session 10.91.23.1-0.8-0.91.3-1.4-1.80.4-0.4-0.9
Locomotion velocity, session 22.52.94.9-2.0-2.02.2-2.2-2.10.1-0.1-1.3
Locomotion distance, session 21.01.43.2-1.0-1.01.4-1.5-1.80.0-0.0-1.2
Locomotion velocity, session 30.70.82.60.40.10.2-0.3-0.91.6-1.6-0.2
Locomotion distance, session 30.00.00.10.20.2-0.10.1-0.10.2-0.2-0.2
Stereotopy head waving bouts, day 30.70.82.30.80.5-0.10.0-0.81.5-1.5-0.6
Stereotopy head waving duration, day 30.40.51.40.90.5-0.50.4-0.11.2-1.20.2
Locomotion velocity, session 70.91.02.90.6-0.30.2-0.3-1.01.7-1.70.5
Locomotion distance, session 70.30.31.20.20.10.4-0.5-1.10.6-0.6-0.6
Stereotopy head waving bouts, day 70.30.30.70.1-0.80.1-0.2-0.10.9-0.90.6
Stereotopy head waving duration, day 70.80.93.0-1.0-1.71.1-1.2-0.80.2-0.20.2
Locomotion velocity, session 80.91.14.5-1.1-0.10.9-0.8-0.8-0.70.7-2.1
Locomotion distance, session 80.40.62.00.50.00.0-0.1-0.71.4-1.4-0.2
Degree of sensitization distance0.40.41.1-0.0-0.20.5-0.6-1.00.8-0.8-0.6
Degree of sensitization stereotypy0.50.52.1-0.7-1.50.8-0.8-0.30.3-0.30.5
Conditioned locomotion1.21.32.1-1.5-1.01.4-1.3-1.1-0.70.7-1.4
Cocaine response after cond. corrected0.80.92.41.41.6-1.11.00.30.6-0.6-0.0
Cocaine response after cond. not corrected0.60.71.61.21.3-0.90.90.20.7-0.7-0.2
Cocaine response before conditioning0.40.51.5-0.9-1.20.8-0.8-0.2-0.40.4-0.2
Saline control response3.24.26.3-2.5-1.82.4-2.3-1.9-1.41.4-2.5
Bone: connectivity density2.53.97.2-2.0-2.72.5-2.5-2.30.6-0.6-1.0
Bone: cortical apparent density0.30.51.7-0.30.2-0.00.10.4-1.31.30.2
Bone: cortical area0.40.71.5-1.1-1.21.0-1.0-0.50.3-0.3-0.5
Bone: cortical porosity0.20.20.4-0.5-0.60.6-0.7-0.70.1-0.10.1
Bone: cortical porosity0.60.61.1-0.9-0.91.0-1.1-1.00.0-0.0-0.4
Bone: cortical thickness1.82.95.0-2.2-1.01.6-1.4-0.8-2.12.1-1.8
Bone: cortical thickness0.60.72.0-0.70.50.4-0.3-0.3-1.41.4-1.0
Bone: cortical tissue density0.40.62.2-0.50.10.1-0.00.3-1.51.50.1
Condit. Reinf. active minus inactive responses0.20.20.5-0.4-0.50.6-0.6-0.7-0.20.20.1
Condit. Reinf. active-inactive response ratio0.10.20.4-0.1-0.20.1-0.1-0.0-0.60.60.6
Condit. Reinf. active responses0.20.30.5-0.1-0.50.4-0.5-0.60.7-0.70.1
Condit. Reinf. inactive responses0.60.82.80.3-0.40.1-0.2-0.51.7-1.7-0.2
Incentive salience index mean0.50.71.6-0.5-1.01.0-1.1-1.30.4-0.40.0
Condit. Reinf. lever presses0.71.01.8-0.7-1.31.1-1.2-1.11.0-1.0-0.3
Condit. Reinf. active minus inactive responses0.20.30.80.2-0.3-0.20.20.40.7-0.70.9
Condit. Reinf. active-inactive response ratio1.11.33.80.8-0.1-0.60.50.62.0-2.01.0
Condit. Reinf. active responses0.10.20.6-0.4-0.80.4-0.4-0.20.0-0.00.7
Condit. Reinf. inactive responses0.60.81.2-0.8-0.70.9-0.9-0.9-1.11.1-0.1
Condit. Reinf. lever presses1.21.74.2-1.7-2.11.6-1.6-0.8-0.00.0-0.4
Condit. Reinf. lever reinforcers received0.20.30.9-0.7-1.00.6-0.6-0.2-0.30.30.4
Conditioned reinforcement - actives0.10.31.40.1-0.4-0.40.41.20.2-0.2-0.2
Conditioned reinforcement - inactives2.33.36.32.11.2-2.32.32.50.9-0.91.5
Conditioned locomotion6.18.013.33.32.8-3.73.63.41.0-1.02.2
Patch foraging indifference point 0 sec0.00.00.10.3-0.0-0.10.0-0.00.1-0.10.0
Patch foraging indifference point AUC1.52.14.0-2.0-1.81.4-1.4-0.4-1.51.5-1.1
Delay disc. indifference point, 0s delay0.50.51.00.4-0.20.2-0.3-1.01.0-1.01.0
Delay disc. indifference point, 16s delay0.50.61.90.80.2-0.60.50.30.8-0.81.4
Delay disc. indifference point, 2s delay0.40.41.10.3-0.40.0-0.1-0.31.1-1.11.0
Delay disc. indifference point, 24s delay0.10.10.30.20.5-0.20.20.0-0.50.5-0.2
Delay disc. indifference point, 4s delay0.20.20.90.2-0.00.3-0.3-0.90.3-0.30.1
Delay disc. indifference point, 8s delay0.10.10.6-0.10.10.3-0.3-0.80.2-0.20.5
Indifference point function ln k4.68.014.23.83.6-3.13.01.52.4-2.42.1
Indifference point function log k4.68.014.23.83.6-3.13.01.52.4-2.42.1
Patch foraging total patch changes 0 sec0.00.10.20.20.3-0.10.10.1-0.30.3-0.4
Patch foraging total patch changes 12 sec3.54.66.6-2.6-2.42.5-2.4-1.8-1.71.7-1.8
Patch foraging total patch changes 18 sec0.50.71.8-1.0-1.31.0-1.0-0.7-0.20.2-0.7
Patch foraging total patch changes 24 sec1.22.13.5-1.8-1.11.3-1.2-0.6-1.61.6-1.9
Patch foraging total patch changes 6 sec0.81.21.7-1.2-1.01.3-1.3-1.2-0.60.6-1.2
Patch foraging time to switch 0 sec1.83.68.3-1.7-2.92.4-2.5-2.30.6-0.6-0.5
Patch foraging water rate 0 sec3.37.013.42.63.7-3.43.43.10.7-0.71.4
Patch foraging water rate 12 sec5.711.825.63.75.1-4.44.43.41.0-1.01.9
Patch foraging water rate 18 sec2.13.28.02.12.8-2.22.21.40.8-0.80.6
Patch foraging water rate 24 sec3.85.411.12.43.3-2.92.92.31.3-1.31.1
Patch foraging water rate 6 sec4.15.915.32.53.9-3.03.02.21.0-1.00.9
Seeking ratio, delayed vs. immediate footshock0.10.10.20.4-0.1-0.0-0.1-0.40.1-0.10.4
Distance traveled before self-admin0.70.92.9-0.9-1.71.1-1.1-0.70.4-0.40.1
Distance traveled after self-admin0.20.30.5-0.5-0.70.4-0.40.0-0.50.50.7
Extensor digitorum longus weight5.923.335.1-5.9-5.35.9-5.8-4.7-2.52.5-4.5
Bone: elastic displacement1.41.75.11.02.2-1.51.61.2-0.60.6-0.5
Bone: elastic work0.91.13.4-1.00.20.8-0.7-0.8-1.21.2-1.8
Bone: endosteal estimation1.43.111.11.2-0.3-0.20.0-0.63.3-3.30.7
Bone: endosteal perimeter1.83.913.11.4-0.4-0.50.3-0.13.6-3.61.4
Epididymis fat weight2.79.313.13.32.3-3.23.02.63.6-3.62.5
Delta time in closed arm before/after self-admin0.60.51.5-0.30.60.5-0.5-1.0-0.60.6-1.2
Delta time in open arm before/after self-admin0.30.31.1-0.4-1.00.2-0.20.60.0-0.00.7
Diff in mean of infusions in LGA sessions0.40.50.9-0.8-0.60.7-0.6-0.4-0.80.8-0.9
Delay discount exponential model param0.20.20.70.00.4-0.40.50.8-0.30.3-0.7
Extinction: sum of active levers before priming2.62.85.2-1.6-2.32.0-2.1-1.8-0.70.7-1.4
Active lever presses in extinction session 62.32.24.6-2.0-2.21.8-1.7-0.9-0.40.4-1.5
Bone: final force1.82.94.7-2.1-2.12.2-2.2-1.60.1-0.1-1.5
Bone: final moment1.72.74.4-2.1-2.02.1-2.1-1.60.0-0.0-1.4
Food consumed during 24 hour testing period0.20.31.0-0.30.0-0.30.41.0-0.60.60.2
Glucose1.62.66.02.00.9-1.10.9-0.22.4-2.41.3
Heart weight1.11.75.01.10.3-0.0-0.2-1.52.2-2.20.1
Delay discount hyperbolic model param0.30.30.70.00.5-0.40.50.8-0.50.5-0.8
Intermittent access intake day 1-15 change0.81.63.91.40.9-1.71.72.00.2-0.20.6
Intermittent access intake escalation0.71.54.01.30.8-1.61.62.00.2-0.20.5
Intermittent access intake escalation 21.21.33.61.20.7-1.51.51.90.2-0.20.7
Intermitt. access day 1 inactive lever presses0.20.61.60.40.3-0.50.60.6-1.31.30.3
Intermitt. access day 15 inactive lever presses0.81.72.81.70.7-1.61.51.50.9-0.91.3
Intermitt. access escalation Index2.33.36.42.01.5-1.71.60.82.0-2.02.5
Intermittent access day 1 total infusions2.13.49.21.90.2-1.10.80.23.0-3.01.9
Intermittent access day 15 total infusions3.65.48.22.91.4-2.72.52.42.2-2.21.9
Intermittent access terminal intake (last 3 days)3.85.08.02.60.9-2.22.01.92.8-2.82.0
Intermittent access total infusions3.13.77.82.20.6-1.71.51.12.8-2.81.6
Intermittent access day 1 locomotion1.31.73.61.60.3-1.00.90.41.9-1.91.3
Intermittent access day 15 total locomotion2.44.46.32.50.8-2.32.22.22.2-2.22.0
Intermittent access total locomotion5.66.711.52.90.7-2.42.21.93.4-3.42.8
Intermittent access standard deviation0.71.52.91.41.2-1.71.71.7-0.10.10.4
Left kidney weight0.52.55.51.70.5-1.21.00.62.4-2.41.9
Right kidney weight0.31.31.71.10.8-1.21.11.01.3-1.31.2
Cocaine induced anxiety0.10.10.30.0-0.50.1-0.10.2-0.30.3-0.0
Post-drug Anxiety0.40.50.9-0.7-0.90.8-0.8-0.4-0.40.4-0.7
Baseline Anxiety0.40.40.9-0.60.10.6-0.5-0.6-0.80.8-1.0
Tail length0.52.04.7-1.5-0.10.8-0.7-0.3-2.22.2-1.7
Length with tail1.56.413.2-3.1-1.62.6-2.4-1.7-2.22.2-3.6
Length without tail1.44.410.4-2.7-1.12.2-2.0-1.5-1.61.6-3.2
Times rat made contact with spout0.50.60.9-0.7-0.50.8-0.8-0.8-0.90.9-0.3
Lifetime Intake2.22.76.01.90.6-1.31.20.72.5-2.51.3
Liver weight, left0.61.02.11.11.4-1.11.10.61.0-1.0-0.2
Liver weight, right1.22.25.22.12.3-1.71.70.60.8-0.8-0.4
Locomotor activity1.92.98.41.92.9-2.22.21.50.1-0.10.1
Locomotor testing distance2.13.811.72.03.4-2.42.41.60.1-0.10.0
Locomotor testing rearing1.53.08.22.02.9-2.12.21.4-0.10.10.6
Locomotion in novel chamber3.94.97.42.72.1-2.62.52.02.0-2.01.5
Locomotion in novel chamber post-restriction2.33.75.82.21.4-2.12.11.81.6-1.62.4
Fecal boli incidents, locomotor time 10.20.20.9-0.1-0.90.0-0.00.50.5-0.50.4
Change in fecal boli incidents, locomotor task0.30.30.80.00.60.3-0.3-0.90.1-0.1-0.9
Time >=10cm from walls, locomotor time 11.51.65.70.8-0.9-0.1-0.0-0.22.4-2.40.6
Bouts of movement, locomotor time 11.82.05.4-1.6-1.10.9-0.70.1-2.32.30.6
Total resting periods, locomotor time 11.21.43.3-1.3-1.10.7-0.60.2-1.81.80.7
Rest time, locomotor task time 11.21.52.31.21.2-1.51.51.40.7-0.71.1
Distance moved, locomotor task time 10.40.61.3-0.3-0.90.8-0.9-1.10.8-0.8-0.1
Vertical activity count, locomotor time 10.30.81.41.21.0-1.01.00.60.8-0.80.4
Time >=10cm from walls, locomotor time 20.10.10.7-0.3-0.80.2-0.20.30.0-0.00.2
Bouts of movement, locomotor time 20.30.51.0-0.7-0.70.6-0.6-0.3-1.01.00.6
Total resting periods, locomotor time 20.20.31.0-0.4-0.60.5-0.4-0.2-0.60.61.0
Rest time, locomotor task time 21.92.44.61.61.4-1.51.40.91.5-1.52.1
Distance moved, locomotor task time 21.01.11.6-1.2-0.91.0-0.9-0.5-1.31.3-1.3
Vertical activity count, locomotor time 20.71.02.80.11.2-0.60.70.7-1.11.1-1.7
Light reinforcement 10.10.20.40.40.5-0.50.60.6-0.50.50.3
Light reinforcement 20.81.32.11.00.3-1.21.11.41.3-1.31.1
Bone: marrow area1.53.211.51.3-0.2-0.30.1-0.73.4-3.40.7
Bone: maximum diameter0.30.61.5-0.5-1.10.5-0.5-0.01.2-1.2-0.1
Bone: maximum force3.05.39.9-2.5-3.22.9-3.0-2.40.8-0.8-1.4
Bone: maximum moment2.84.99.0-2.4-3.02.8-2.8-2.40.8-0.8-1.4
Mean time between licks in bursts0.30.72.4-0.50.40.5-0.4-0.8-1.01.0-1.6
Mean num. licks in bursts0.10.20.40.50.7-0.40.40.1-0.40.40.3
Cd content in liver1.31.53.71.20.4-1.31.21.40.9-0.91.9
Co content in liver2.12.45.51.22.3-1.71.81.5-1.31.30.5
Cu content in liver0.10.10.40.2-0.30.1-0.2-0.3-0.00.00.6
Fe content in liver0.40.53.4-0.40.00.2-0.2-0.10.0-0.0-1.8
K content in liver1.01.02.1-0.6-0.91.1-1.2-1.40.8-0.8-0.9
Mg content in liver0.40.41.00.70.5-0.20.1-0.41.0-1.00.1
Mn content in liver2.12.44.3-2.1-2.01.8-1.8-1.0-0.40.4-1.7
Na content in liver0.20.30.9-0.7-0.20.4-0.30.1-0.40.4-1.0
Rb content in liver1.31.52.81.61.7-1.41.30.51.0-1.01.1
Se content in liver0.30.41.00.4-0.1-0.50.50.71.0-1.00.4
Sr content in liver1.51.32.9-1.7-1.21.2-1.0-0.3-1.31.3-0.5
Zn content in liver0.30.30.5-0.5-0.70.7-0.7-0.7-0.50.5-0.1
Bone: minimum diameter1.52.88.81.2-0.5-0.1-0.1-0.83.0-3.01.6
Time in familiar zone, hab. session 10.30.30.70.60.1-0.20.2-0.20.9-0.90.4
Time in novel zone, hab. session 10.40.41.50.41.2-0.60.70.5-0.50.5-0.3
Total zone transitions, hab. session 10.50.81.1-1.0-1.01.1-1.1-0.9-0.60.6-0.4
Total locomotion distance, hab. session 10.20.31.10.5-0.0-0.10.0-0.41.0-1.00.2
Locomotion velocity, hab. session 10.10.20.30.0-0.40.3-0.4-0.60.5-0.5-0.1
Time in familiar zone, hab. session 20.30.31.70.20.8-0.20.2-0.1-0.40.4-1.3
Time in novel zone, hab. session 20.30.31.0-0.4-0.70.4-0.5-0.30.1-0.11.0
Total zone transitions, hab. session 22.12.75.8-1.4-1.92.1-2.2-2.40.4-0.4-0.7
Total locomotion distance, hab. session 20.71.02.60.0-0.70.8-1.0-1.61.2-1.2-0.1
Locomotion velocity, hab. session 20.81.12.40.2-0.70.7-0.8-1.41.6-1.60.2
Novel to familiar place preference ratio0.80.93.1-1.2-1.81.1-1.1-0.4-0.30.30.4
Novelty place preference0.50.51.9-0.8-1.40.7-0.7-0.1-0.20.20.7
Time in novel zone, NPP test0.30.41.3-0.7-1.20.6-0.6-0.1-0.20.20.6
Total zone transitions, NPP test2.13.05.0-2.0-2.12.2-2.2-2.0-0.30.3-1.2
Total locomotion distance, NPP test0.40.51.4-0.3-0.60.8-0.8-1.20.6-0.6-0.1
Locomotion velocity, NPP test0.30.41.2-0.4-0.70.8-0.9-1.10.4-0.40.0
Intraocular pressure1.31.95.51.20.9-1.81.82.3-0.30.30.9
Delta distance traveled before/after self-admin0.60.61.50.41.2-0.60.70.5-1.01.00.2
Delta ambulatory time before/after self-admin0.40.51.30.21.0-0.40.50.3-1.21.2-0.1
Parametrial fat weight2.45.78.82.91.3-2.32.11.33.0-3.02.6
Pavlov. Cond. lever latency0.40.50.90.60.8-0.90.90.9-0.40.40.5
Pavlov. Cond. magazine entry latency0.70.92.0-0.5-1.41.1-1.1-1.10.6-0.60.6
Pavlov. Cond. change in total contacts0.50.51.5-0.3-1.20.5-0.6-0.30.5-0.51.2
Pavlov. Cond. index score0.20.30.9-0.5-0.90.7-0.7-0.40.1-0.10.3
Pavlov. Cond. latency score0.20.30.7-0.4-0.80.7-0.7-0.70.3-0.30.1
Pavlov. Cond. lever contacts0.30.40.8-0.3-0.60.7-0.7-0.90.6-0.6-0.2
Pavlov. Cond. magazine entry number0.20.30.90.60.9-0.60.50.00.3-0.3-0.6
Pavlov. Cond. intertrial magazine entries0.80.91.80.90.7-1.21.21.3-0.00.01.2
Pavlov. Cond. lever-magazine prob. diff.0.50.61.6-0.6-1.30.9-1.0-0.70.1-0.10.4
Pavlov. Cond. response bias0.20.20.6-0.5-0.80.5-0.5-0.2-0.10.10.4
Pavlov. Cond. lever latency0.40.51.41.01.2-0.80.70.2-0.30.30.3
Pavlov. Cond. magazine entry latency3.44.18.1-2.4-2.92.6-2.6-1.9-0.90.9-0.9
Pavlov. Cond. change in total contacts1.21.86.4-1.6-2.51.6-1.6-0.7-0.10.10.4
Pavlov. Cond. index score1.82.56.6-2.0-2.62.0-2.0-1.2-0.20.2-0.4
Pavlov. Cond. latency score1.62.15.9-1.8-2.41.8-1.8-1.10.0-0.0-0.4
Pavlov. Cond. lever contacts0.40.51.5-1.0-1.20.8-0.8-0.20.2-0.2-0.3
Pavlov. Cond. magazine entry number5.16.212.13.23.5-3.13.01.91.4-1.41.1
Pavlov. Cond. intertrial magazine entries0.81.21.71.31.1-1.31.21.00.9-0.90.8
Pavlov. Cond. lever-magazine prob. diff.2.22.97.5-2.2-2.72.1-2.1-1.3-0.40.4-0.5
Pavlov. Cond. response bias1.52.05.0-1.9-2.21.8-1.8-1.0-0.20.2-0.5
Time in closed arm before self-admin0.20.30.60.5-0.3-0.40.30.50.8-0.80.3
Time in closed arm after self-admin0.20.20.50.60.7-0.40.4-0.10.2-0.2-0.2
Time in open arm before self-admin0.50.62.30.41.5-0.30.3-0.5-0.90.9-0.3
Time in open arm after self-admin0.10.10.3-0.30.10.2-0.1-0.1-0.50.50.2
Bone: periosteal estimation0.81.65.30.0-1.00.5-0.6-0.72.3-2.30.2
Bone: periosteal perimeter0.61.12.6-0.4-1.20.7-0.8-0.71.6-1.60.1
Bone: post-yield work4.56.611.1-0.8-3.32.2-2.5-2.63.3-3.31.2
Progressive ratio test 1 active lever presses0.30.30.50.60.2-0.60.50.70.7-0.70.7
Progressive ratio test 1 breakpoint0.20.30.40.50.1-0.50.50.70.6-0.60.6
Progressive ratio test 1 inactive lever presses0.20.30.60.30.1-0.40.40.7-0.80.80.3
Progressive ratio test 2 active lever presses2.02.33.31.80.8-1.81.71.71.4-1.41.3
Progressive ratio test 2 breakpoint2.02.33.21.80.8-1.81.71.81.4-1.41.3
Progressive ratio test 2 inactive lever presses4.77.711.63.41.9-3.33.12.92.2-2.22.8
Incentive Sensitization - Responses0.30.41.20.2-0.60.1-0.2-0.11.1-1.10.0
Incentive Sensitization - Breakpoint0.30.31.20.4-0.4-0.10.00.11.1-1.10.1
Sum of active levers in priming session hrs 5-61.11.02.1-1.0-0.80.10.11.4-1.21.2-1.3
Progressive ratio1.93.06.3-1.2-2.52.1-2.2-2.21.0-1.0-0.8
Food seeking constrained by brief footshock0.20.31.3-0.20.10.2-0.2-0.4-0.50.5-1.2
Seeking ratio, punishment vs. effort1.82.77.21.42.7-2.02.01.6-0.90.90.4
Retroperitoneal fat weight6.427.244.86.75.6-6.15.83.94.5-4.54.0
Reaction time number correct0.10.31.0-0.80.00.2-0.20.1-0.50.5-1.0
Reaction time mean minus median1.53.67.2-2.3-2.72.3-2.2-1.3-1.31.3-1.3
Reaction time mean minus median AUC0.82.02.8-1.7-1.61.4-1.4-0.6-1.51.5-1.2
Reaction time num false alarms0.40.62.50.81.6-0.70.7-0.0-0.40.4-0.5
Reaction time num false alarms AUC0.30.51.00.20.9-0.00.1-0.5-0.90.9-1.0
Reaction time trials correct on left0.10.31.0-0.80.00.2-0.20.1-0.50.5-1.0
Reaction time trials on left0.20.41.3-0.9-0.00.3-0.20.1-0.60.6-1.1
Reaction time mean0.10.20.4-0.4-0.60.2-0.20.3-0.60.60.5
Reaction time mean AUC0.10.20.5-0.3-0.70.2-0.20.2-0.60.60.6
Median of all reaction times0.10.21.00.2-0.1-0.30.30.5-0.20.21.0
Reaction time omissions1.52.23.3-1.8-1.51.5-1.5-0.9-1.71.7-1.1
Reaction time false alarm rate0.20.31.30.81.1-0.40.4-0.3-0.20.2-0.4
Reaction time premature initiation rate1.92.63.7-1.8-0.61.8-1.7-1.7-1.51.5-1.9
Reaction time premature initiations2.34.16.2-2.5-0.82.0-1.8-1.5-2.32.3-2.5
Std. dev. reaction times0.71.22.2-1.3-1.51.1-1.1-0.4-1.21.2-0.5
Reaction time trials completed0.20.41.3-0.9-0.00.3-0.20.1-0.60.6-1.1
Reaction time trials AUC0.10.31.1-0.70.20.2-0.10.1-0.50.5-1.0
Run reversals in cocaine runway, females1.21.24.5-0.6-0.71.3-1.4-2.10.6-0.6-0.2
Run reversals in cocaine runway, males0.80.91.90.51.4-1.11.21.3-0.10.10.4
Latency to leave start box in cocaine runway0.40.41.00.4-0.70.3-0.4-0.71.0-1.00.2
Latency to leave start box in cocaine runway, F0.20.20.40.1-0.60.2-0.3-0.50.3-0.30.7
Latency to leave start box in cocaine runway, M0.50.41.00.1-0.30.3-0.4-0.61.0-1.0-1.0
Std. dev. time between licks in bursts0.20.31.40.21.2-0.20.3-0.2-0.30.3-0.9
Total sessions with >9 infusions0.60.82.4-0.0-0.50.4-0.5-0.71.6-1.60.5
Short access day 1 total inactive lever presses1.21.63.21.81.5-1.61.50.90.5-0.50.8
Short access day 10 total inactive lever presses0.30.81.70.91.0-0.80.80.3-1.31.3-0.4
Short access day 1 total infusions1.21.63.71.30.6-0.90.70.11.9-1.91.3
Short access day 10 total infusions1.41.85.50.6-0.80.1-0.3-0.82.3-2.31.1
Short access total infusions0.81.03.50.6-0.1-0.1-0.1-0.61.9-1.90.3
Short access day 1 locomotion1.21.52.41.50.7-1.11.00.51.5-1.51.4
Short access day 10 total locomotion0.50.92.01.0-0.1-0.70.60.41.4-1.41.0
Short access total locomotion1.21.53.31.30.3-0.90.80.51.8-1.81.4
One hour access (0.3 mA shock)4.85.58.93.02.2-2.92.82.21.9-1.91.6
Compulsive drug intake1.61.93.2-1.60.21.2-1.0-1.1-1.81.8-1.6
One hour access (shock baseline)4.46.810.63.31.6-3.02.92.72.3-2.32.4
Social response proportion0.40.51.0-0.9-1.00.8-0.8-0.3-0.40.4-0.5
Social responses0.30.41.0-0.6-0.20.3-0.20.0-0.90.9-1.0
Social time0.50.71.9-0.90.00.4-0.3-0.1-1.21.2-1.4
Soleus weight2.98.614.13.83.3-3.53.42.32.3-2.32.3
Bone: stiffness2.23.68.1-2.1-2.92.4-2.4-1.80.6-0.6-0.7
Tibialis anterior weight7.023.840.7-6.4-4.95.5-5.3-3.4-3.63.6-5.4
Time to tail flick, vehicle, before self-admin0.40.50.9-0.5-0.90.8-0.8-0.80.5-0.5-0.4
Time to tail flick, vehicle, after self-admin1.62.25.2-0.8-1.61.7-1.8-2.31.0-1.0-1.0
Time to tail flick, test, before self-admin1.51.53.51.50.8-0.80.6-0.41.9-1.91.2
Time to tail flick, test, after self-admin0.00.00.2-0.3-0.40.1-0.10.3-0.00.0-0.0
Delta time to tail flick, vehicle, before/after SA0.70.71.8-0.6-0.81.0-1.1-1.30.2-0.2-0.7
Delta time to tail flick, test, before/after SA1.81.84.7-1.5-0.50.4-0.11.1-2.22.2-1.1
Tibia length0.51.34.4-1.8-2.11.2-1.10.20.3-0.3-0.5
Ambulatory time before self-admin0.50.72.8-0.7-1.70.9-0.9-0.40.6-0.60.2
Ambulatory time after self-admin0.30.42.20.4-0.4-0.30.30.40.4-0.41.5
Bone: tissue strength0.00.00.0-0.1-0.20.1-0.1-0.00.1-0.1-0.1
Total heroin consumption4.45.17.2-2.7-2.62.5-2.4-1.6-2.02.0-2.1
Bone: trabecular number1.11.94.5-1.1-2.11.5-1.6-1.41.1-1.1-0.0
Bone: trabecular spacing0.50.61.80.71.3-0.80.80.4-0.80.80.0
Bone: trabecular thickness0.40.51.20.6-0.0-0.30.2-0.11.1-1.11.0
Bone: trabecular tissue density3.14.67.42.62.3-2.72.72.31.0-1.01.7
Water consumed over 24 hours0.81.12.3-1.3-0.70.9-0.8-0.4-1.51.5-0.3
Number of responses in last shaping day0.20.20.50.10.5-0.20.30.2-0.70.7-0.2