Cdca5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	alternative polyA	XM_008760176.2	0.04	0.02	4.1e-04	0.01	0.01	0.01	0	5.9e-02	8.1e-03	1.5e-02	8.8e-02
2	PL	alternative polyA	XM_008760176.2	0.04	0.03	8.6e-05	0.04	0.04	0.04	0.04	2.6e-05	2.8e-05	1.7e-05	1.5e-05
3	Brain	gene expression	Cdca5	0.04	0.03	6.8e-03	0	0.02	0.01	0.01	1.2e-01	5.0e-03	1.3e-02	4.0e-02
4	RMTg	alternative TSS	NM_001115042.2	0.14	0.09	3.7e-03	0.07	0.07	0.03	0.05	5.3e-03	5.3e-03	5.8e-02	1.6e-02
5	RMTg	alternative TSS	XM_008760177.3	0.14	0.09	4.9e-03	0.07	0.07	0.01	0.05	5.8e-03	7.7e-03	1.4e-01	1.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.1	1.8	2.0	-1.4	-1.4	1.4	-1.3	1.3
Area under the delay curve	0.1	0.1	0.1	-0.0	0.1	-0.3	0.4	-0.4
BMI with tail	3.8	12.3	17.8	-4.0	-4.2	3.9	-2.5	2.5
BMI without tail	1.4	2.8	5.6	-2.0	-2.4	1.7	-0.9	0.9
Body weight	2.5	10.3	18.3	-4.2	-4.3	4.0	0.3	-0.3
Weight adjusted by age	1.8	2.1	2.8	-1.7	-1.6	1.7	1.1	-1.1
Bone surface	4.5	7.9	14.9	-3.7	-3.3	3.9	-0.4	0.4
Bone volume	2.7	4.5	8.4	-2.6	-2.3	2.9	-1.0	1.0
Breakpoint value in progressive ratio session	2.8	3.1	4.5	-2.1	-2.0	2.0	1.2	-1.2
Number of licking bursts	0.3	0.3	0.5	-0.7	-0.7	0.7	0.2	-0.2
Context. condit. distance diff. score	1.5	1.8	2.4	1.6	1.4	-1.5	-1.1	1.1
Locomotion velocity, session 1	0.1	0.2	0.3	0.4	0.2	-0.5	0.4	-0.4
Locomotion distance, session 1	0.3	0.4	1.0	-0.8	-1.0	0.6	-0.1	0.1
Locomotion velocity, session 2	1.9	2.3	3.9	-1.9	-2.0	1.7	0.6	-0.6
Locomotion distance, session 2	0.4	0.5	1.3	-0.9	-1.1	0.6	0.3	-0.3
Locomotion velocity, session 3	0.8	1.0	2.4	0.2	0.0	-0.1	-1.6	1.6
Locomotion distance, session 3	0.0	0.1	0.1	0.3	0.2	-0.3	-0.2	0.2
Stereotopy head waving bouts, day 3	1.3	1.5	3.2	0.7	0.5	-0.5	-1.8	1.8
Stereotopy head waving duration, day 3	0.8	1.0	1.9	0.7	0.7	-0.5	-1.4	1.4
Locomotion velocity, session 7	1.0	1.1	2.8	0.0	-0.1	0.0	-1.7	1.7
Locomotion distance, session 7	0.2	0.2	0.3	0.4	-0.1	-0.5	-0.5	0.5
Stereotopy head waving bouts, day 7	0.6	0.7	1.5	-0.4	-0.1	0.6	-1.2	1.2
Stereotopy head waving duration, day 7	1.5	1.8	3.1	-1.7	-1.5	1.8	-0.4	0.4
Locomotion velocity, session 8	0.3	0.3	0.6	-0.3	-0.5	0.2	0.7	-0.7
Locomotion distance, session 8	0.5	0.7	1.8	0.1	0.0	-0.0	-1.3	1.3
Degree of sensitization distance	0.4	0.4	0.9	-0.0	-0.2	0.0	-1.0	1.0
Degree of sensitization stereotypy	1.1	1.2	2.3	-1.4	-1.1	1.5	-0.5	0.5
Conditioned locomotion	0.7	0.8	1.4	-1.1	-1.2	1.0	0.5	-0.5
Cocaine response after cond. corrected	1.7	1.9	2.9	1.7	1.5	-1.7	-0.8	0.8
Cocaine response after cond. not corrected	1.3	1.5	2.2	1.5	1.3	-1.4	-0.8	0.8
Cocaine response before conditioning	0.7	0.9	1.5	-1.2	-1.0	1.2	0.5	-0.5
Saline control response	2.2	2.9	4.4	-1.9	-2.1	1.6	1.4	-1.4
Bone: connectivity density	2.2	3.5	5.7	-2.4	-2.4	2.3	-0.5	0.5
Bone: cortical apparent density	0.7	1.0	2.3	-0.3	-0.4	-0.1	1.5	-1.5
Bone: cortical area	0.6	0.9	2.0	-1.3	-1.0	1.4	-0.2	0.2
Bone: cortical porosity	0.3	0.3	0.4	-0.5	-0.7	0.5	-0.5	0.5
Bone: cortical porosity	0.5	0.5	1.1	-0.9	-1.1	0.8	-0.1	0.1
Bone: cortical thickness	1.7	2.8	4.7	-1.3	-1.5	0.9	2.2	-2.2
Bone: cortical thickness	1.0	1.1	2.7	0.2	-0.1	-0.6	1.6	-1.6
Bone: cortical tissue density	0.9	1.2	2.7	-0.3	-0.5	-0.1	1.7	-1.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	-0.4	-0.6	0.2	0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.1	-0.2	-0.1	0.6	-0.6
Condit. Reinf. active responses	0.1	0.2	0.3	-0.4	-0.5	0.4	-0.3	0.3
Condit. Reinf. inactive responses	0.6	0.8	1.6	-0.3	-0.3	0.6	-1.3	1.3
Incentive salience index mean	0.3	0.4	0.9	-0.7	-1.0	0.6	-0.2	0.2
Condit. Reinf. lever presses	0.6	0.8	1.3	-1.0	-0.9	1.1	-0.6	0.6
Condit. Reinf. active minus inactive responses	0.2	0.3	0.6	-0.2	0.1	0.4	-0.7	0.7
Condit. Reinf. active-inactive response ratio	1.5	1.6	3.7	-0.2	0.3	0.7	-1.9	1.9
Condit. Reinf. active responses	0.1	0.2	0.4	-0.6	-0.4	0.6	0.0	-0.0
Condit. Reinf. inactive responses	0.5	0.7	1.4	-0.4	-0.6	-0.1	1.2	-1.2
Condit. Reinf. lever presses	2.1	2.9	5.7	-2.3	-1.8	2.4	0.2	-0.2
Condit. Reinf. lever reinforcers received	0.4	0.5	0.9	-1.0	-0.7	0.9	0.3	-0.3
Conditioned reinforcement - actives	0.1	0.1	0.3	-0.0	0.5	0.4	0.3	-0.3
Conditioned reinforcement - inactives	2.6	2.9	7.4	2.0	2.7	-1.5	-0.5	0.5
Conditioned locomotion	4.7	5.6	12.4	3.0	3.5	-2.5	-0.4	0.4
Patch foraging indifference point 0 sec	0.0	0.0	0.0	0.2	0.2	-0.1	-0.1	0.1
Patch foraging indifference point AUC	3.0	3.4	5.0	-2.2	-2.0	2.1	1.3	-1.3
Delay disc. indifference point, 0s delay	0.2	0.2	0.6	0.5	0.5	-0.7	0.1	-0.1
Delay disc. indifference point, 16s delay	0.3	0.3	0.4	0.4	0.7	-0.5	-0.5	0.5
Delay disc. indifference point, 2s delay	0.3	0.3	0.8	0.0	0.0	-0.0	-0.9	0.9
Delay disc. indifference point, 24s delay	0.9	0.9	1.3	0.7	0.7	-1.0	1.1	-1.1
Delay disc. indifference point, 4s delay	0.4	0.4	0.7	0.5	0.5	-0.9	0.6	-0.6
Delay disc. indifference point, 8s delay	0.4	0.4	0.6	0.3	0.3	-0.7	0.8	-0.8
Indifference point function ln k	7.7	10.7	16.1	4.0	3.7	-3.9	-2.0	2.0
Indifference point function log k	7.7	10.7	16.1	4.0	3.7	-3.9	-2.0	2.0
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	0.4	0.3	-0.4	0.3	-0.3
Patch foraging total patch changes 12 sec	3.7	4.8	6.9	-2.6	-2.6	2.3	1.6	-1.6
Patch foraging total patch changes 18 sec	0.6	0.8	1.6	-1.2	-1.0	1.2	0.2	-0.2
Patch foraging total patch changes 24 sec	1.8	2.3	2.6	-1.5	-1.4	1.4	1.6	-1.6
Patch foraging total patch changes 6 sec	0.4	0.7	1.3	-0.9	-1.1	0.8	0.5	-0.5
Patch foraging time to switch 0 sec	2.7	4.1	6.7	-2.6	-2.4	2.6	-0.8	0.8
Patch foraging water rate 0 sec	3.7	5.9	10.5	3.2	3.2	-3.0	-0.4	0.4
Patch foraging water rate 12 sec	8.6	13.1	23.3	4.8	4.4	-4.7	-0.7	0.7
Patch foraging water rate 18 sec	3.4	4.6	8.0	2.8	2.6	-2.8	-0.6	0.6
Patch foraging water rate 24 sec	3.9	5.5	9.5	3.1	2.9	-2.9	-0.8	0.8
Patch foraging water rate 6 sec	4.9	7.1	12.7	3.6	3.3	-3.5	-0.5	0.5
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.1	-0.1	-0.3	-0.2	0.2
Distance traveled before self-admin	0.9	0.9	1.9	-1.3	-1.0	1.4	0.1	-0.1
Distance traveled after self-admin	0.2	0.3	0.5	-0.7	-0.5	0.7	0.1	-0.1
Extensor digitorum longus weight	4.9	19.2	31.3	-5.5	-5.6	5.0	2.1	-2.1
Bone: elastic displacement	2.4	2.8	5.0	2.2	1.9	-2.2	0.5	-0.5
Bone: elastic work	0.6	0.7	1.7	0.2	-0.1	-0.5	1.3	-1.3
Bone: endosteal estimation	2.1	4.5	11.1	0.1	0.5	0.4	-3.3	3.3
Bone: endosteal perimeter	2.6	5.3	12.8	-0.1	0.5	0.8	-3.6	3.6
Epididymis fat weight	1.9	4.4	6.3	1.8	2.2	-1.3	-2.5	2.5
Delta time in closed arm before/after self-admin	0.8	0.7	1.3	0.9	0.4	-1.1	0.9	-0.9
Delta time in open arm before/after self-admin	0.3	0.3	0.9	-0.8	-0.3	0.9	0.2	-0.2
Diff in mean of infusions in LGA sessions	1.1	1.2	2.7	-0.5	-0.2	0.4	1.6	-1.6
Delay discount exponential model param	0.1	0.1	0.2	-0.0	-0.1	0.3	-0.5	0.5
Extinction: sum of active levers before priming	4.1	4.1	7.1	-2.6	-2.7	2.3	0.9	-0.9
Active lever presses in extinction session 6	2.3	2.3	3.6	-1.7	-1.4	1.9	1.2	-1.2
Bone: final force	2.3	3.7	6.4	-2.5	-2.4	2.5	0.2	-0.2
Bone: final moment	2.0	3.2	5.7	-2.3	-2.2	2.4	0.2	-0.2
Food consumed during 24 hour testing period	0.2	0.3	0.6	-0.2	0.1	0.3	0.8	-0.8
Glucose	1.7	2.5	4.9	1.0	1.1	-0.7	-2.2	2.2
Heart weight	2.6	3.7	5.6	2.3	2.4	-2.2	-1.1	1.1
Delay discount hyperbolic model param	0.1	0.1	0.1	0.0	-0.0	0.3	-0.4	0.4
Intermittent access intake day 1-15 change	0.4	0.4	1.2	0.6	1.1	-0.3	0.4	-0.4
Intermittent access intake escalation	0.2	0.2	0.9	0.5	0.9	-0.2	0.1	-0.1
Intermittent access intake escalation 2	0.2	0.2	0.4	0.2	0.6	0.0	0.6	-0.6
Intermitt. access day 1 inactive lever presses	1.0	1.1	2.7	1.3	1.7	-1.1	0.0	-0.0
Intermitt. access day 15 inactive lever presses	0.9	1.0	3.0	1.1	1.7	-0.7	-0.3	0.3
Intermitt. access escalation Index	3.6	3.2	4.0	1.7	1.3	-1.8	-2.0	2.0
Intermittent access day 1 total infusions	3.8	4.4	8.0	1.4	1.8	-0.9	-2.8	2.8
Intermittent access day 15 total infusions	4.1	4.6	8.3	2.1	2.9	-1.4	-2.0	2.0
Intermittent access terminal intake (last 3 days)	3.4	3.8	6.1	1.4	2.1	-0.6	-2.5	2.5
Intermittent access total infusions	3.1	3.4	6.1	1.2	1.8	-0.6	-2.5	2.5
Intermittent access day 1 locomotion	2.2	2.3	3.0	1.4	1.6	-1.1	-1.7	1.7
Intermittent access day 15 total locomotion	1.7	1.8	5.0	1.5	2.2	-1.0	-0.6	0.6
Intermittent access total locomotion	3.2	3.6	6.0	1.3	2.0	-0.7	-2.5	2.5
Intermittent access standard deviation	0.7	0.7	2.1	0.9	1.5	-0.6	0.3	-0.3
Left kidney weight	0.4	1.2	2.0	0.8	1.0	-0.5	-1.4	1.4
Right kidney weight	0.1	0.3	0.4	-0.1	0.6	0.5	-0.6	0.6
Cocaine induced anxiety	0.2	0.2	0.3	-0.3	-0.1	0.5	-0.5	0.5
Post-drug Anxiety	1.3	1.4	2.5	-1.4	-1.1	1.6	0.8	-0.8
Baseline Anxiety	2.6	2.8	5.1	-1.1	-1.3	1.0	2.3	-2.3
Tail length	0.9	2.6	6.4	-0.3	-0.5	-0.0	2.5	-2.5
Length with tail	1.3	4.6	6.1	-2.0	-2.0	1.8	2.5	-2.5
Length without tail	1.2	2.7	3.8	-1.9	-1.8	1.9	1.1	-1.1
Times rat made contact with spout	0.6	0.7	1.5	-0.4	-0.6	0.0	1.2	-1.2
Lifetime Intake	2.8	3.2	5.6	1.2	1.7	-0.7	-2.4	2.4
Liver weight, left	0.2	0.3	0.7	0.1	-0.0	-0.0	-0.9	0.9
Liver weight, right	0.3	0.5	0.9	0.6	0.5	-0.5	-1.0	1.0
Locomotor activity	2.7	4.3	7.4	2.7	2.5	-2.7	0.5	-0.5
Locomotor testing distance	4.0	6.7	12.0	3.4	3.0	-3.5	0.5	-0.5
Locomotor testing rearing	2.9	4.5	8.1	2.8	2.5	-2.8	0.6	-0.6
Locomotion in novel chamber	2.4	3.0	5.5	1.7	2.4	-1.0	-1.7	1.7
Locomotion in novel chamber post-restriction	2.0	2.4	3.4	1.6	1.9	-1.3	-1.4	1.4
Fecal boli incidents, locomotor time 1	0.7	0.8	1.9	-1.1	-0.4	1.4	-0.6	0.6
Change in fecal boli incidents, locomotor task	0.3	0.2	0.6	0.6	0.2	-0.8	0.3	-0.3
Time >=10cm from walls, locomotor time 1	1.5	1.5	3.1	-0.5	0.2	1.0	-1.8	1.8
Bouts of movement, locomotor time 1	2.7	3.0	5.7	-1.2	-1.1	0.9	2.4	-2.4
Total resting periods, locomotor time 1	1.9	2.1	3.5	-1.2	-1.0	1.0	1.9	-1.9
Rest time, locomotor task time 1	0.9	1.0	2.4	1.2	1.6	-1.0	-0.1	0.1
Distance moved, locomotor task time 1	0.4	0.5	0.7	-0.6	-0.7	0.5	-0.8	0.8
Vertical activity count, locomotor time 1	1.0	1.0	1.5	1.2	1.2	-1.1	-0.7	0.7
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.9	-0.8	-0.4	0.9	0.1	-0.1
Bouts of movement, locomotor time 2	0.9	0.9	1.8	-0.7	-0.6	0.4	1.4	-1.4
Total resting periods, locomotor time 2	0.6	0.6	1.3	-0.6	-0.4	0.3	1.1	-1.1
Rest time, locomotor task time 2	1.4	1.6	3.4	1.5	1.9	-1.2	-0.6	0.6
Distance moved, locomotor task time 2	0.7	0.8	1.6	-1.0	-1.3	0.8	0.7	-0.7
Vertical activity count, locomotor time 2	0.7	0.8	1.2	1.0	0.6	-1.1	0.8	-0.8
Light reinforcement 1	0.3	0.6	0.7	0.7	0.6	-0.8	0.8	-0.8
Light reinforcement 2	0.6	0.7	1.4	0.3	0.9	0.2	-1.2	1.2
Bone: marrow area	2.1	4.5	11.1	0.2	0.5	0.3	-3.3	3.3
Bone: maximum diameter	0.8	1.4	2.9	-1.2	-0.6	1.7	-1.1	1.1
Bone: maximum force	3.7	6.3	11.5	-3.2	-3.0	3.4	-0.7	0.7
Bone: maximum moment	3.1	5.4	9.8	-3.0	-2.7	3.1	-0.7	0.7
Mean time between licks in bursts	0.5	0.6	1.4	0.3	-0.2	-0.6	1.2	-1.2
Mean num. licks in bursts	0.3	0.4	0.9	0.7	0.6	-0.9	0.4	-0.4
Cd content in liver	0.6	0.6	1.5	0.8	1.2	-0.5	-0.6	0.6
Co content in liver	3.4	4.0	7.0	2.3	1.8	-2.7	1.5	-1.5
Cu content in liver	0.4	0.4	0.7	-0.7	-0.8	0.5	0.6	-0.6
Fe content in liver	0.1	0.2	0.5	-0.5	-0.3	0.7	-0.1	0.1
K content in liver	1.7	1.7	2.8	-1.6	-1.7	1.5	-0.6	0.6
Mg content in liver	0.9	0.9	1.1	-0.8	-1.0	0.7	-1.0	1.0
Mn content in liver	2.3	2.6	4.8	-2.1	-1.8	2.2	0.6	-0.6
Na content in liver	0.8	0.8	1.8	-1.2	-1.0	1.3	0.1	-0.1
Rb content in liver	0.9	1.1	1.3	1.1	0.9	-1.1	-1.1	1.1
Se content in liver	0.6	0.7	1.6	-0.9	-0.3	1.2	-0.8	0.8
Sr content in liver	2.6	2.4	2.9	-1.5	-1.5	1.3	1.7	-1.7
Zn content in liver	1.2	1.3	2.2	-1.3	-1.5	1.1	0.8	-0.8
Bone: minimum diameter	1.8	3.3	8.1	-0.0	0.1	0.4	-2.8	2.8
Time in familiar zone, hab. session 1	0.4	0.3	0.8	0.2	0.2	-0.1	-0.9	0.9
Time in novel zone, hab. session 1	1.1	1.0	1.4	1.1	1.0	-1.2	0.9	-0.9
Total zone transitions, hab. session 1	0.6	0.8	1.3	-1.1	-1.1	0.9	0.7	-0.7
Total locomotion distance, hab. session 1	0.2	0.3	0.8	0.1	0.2	-0.1	-0.9	0.9
Locomotion velocity, hab. session 1	0.2	0.2	0.5	-0.2	-0.3	0.3	-0.7	0.7
Time in familiar zone, hab. session 2	0.5	0.5	1.1	0.9	0.6	-1.1	0.2	-0.2
Time in novel zone, hab. session 2	0.3	0.3	0.6	-0.8	-0.6	0.7	0.2	-0.2
Total zone transitions, hab. session 2	1.4	1.8	3.6	-1.7	-1.9	1.5	-0.2	0.2
Total locomotion distance, hab. session 2	0.5	0.6	1.3	-0.4	-0.6	0.3	-1.1	1.1
Locomotion velocity, hab. session 2	0.7	1.0	2.3	-0.4	-0.4	0.4	-1.5	1.5
Novel to familiar place preference ratio	1.9	2.0	3.9	-1.9	-1.5	2.0	0.4	-0.4
Novelty place preference	1.1	1.2	2.3	-1.5	-1.1	1.5	0.3	-0.3
Time in novel zone, NPP test	0.8	0.8	1.6	-1.2	-0.9	1.3	0.2	-0.2
Total zone transitions, NPP test	1.9	2.7	4.5	-2.1	-2.1	1.9	0.7	-0.7
Total locomotion distance, NPP test	0.2	0.2	0.3	-0.5	-0.6	0.4	-0.4	0.4
Locomotion velocity, NPP test	0.2	0.2	0.4	-0.6	-0.7	0.5	-0.2	0.2
Intraocular pressure	0.4	0.6	2.0	0.7	1.4	-0.2	0.5	-0.5
Delta distance traveled before/after self-admin	0.2	0.2	0.6	0.7	0.4	-0.7	0.1	-0.1
Delta ambulatory time before/after self-admin	0.3	0.4	0.7	0.7	0.3	-0.9	0.5	-0.5
Parametrial fat weight	2.0	3.9	8.5	1.0	1.1	-0.6	-2.9	2.9
Pavlov. Cond. lever latency	0.4	0.5	0.8	0.9	0.8	-0.9	0.3	-0.3
Pavlov. Cond. magazine entry latency	0.6	0.7	1.3	-1.1	-1.0	1.0	-0.3	0.3
Pavlov. Cond. change in total contacts	0.6	0.6	1.3	-1.0	-0.8	1.1	-0.3	0.3
Pavlov. Cond. index score	0.3	0.3	0.6	-0.8	-0.7	0.8	0.1	-0.1
Pavlov. Cond. latency score	0.2	0.2	0.4	-0.6	-0.6	0.6	-0.2	0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.1	-0.2	-0.3	0.2	-0.3	0.3
Pavlov. Cond. magazine entry number	0.5	0.6	0.9	1.0	0.7	-0.9	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.7	0.8	0.8	-0.6	-0.1	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.2	-1.1	-1.0	1.0	0.1	-0.1
Pavlov. Cond. response bias	0.2	0.2	0.4	-0.6	-0.5	0.6	0.2	-0.2
Pavlov. Cond. lever latency	0.7	1.0	2.2	1.3	0.9	-1.5	0.3	-0.3
Pavlov. Cond. magazine entry latency	2.9	3.3	5.5	-2.3	-2.3	2.1	0.9	-0.9
Pavlov. Cond. change in total contacts	2.7	3.7	7.4	-2.6	-2.1	2.7	0.1	-0.1
Pavlov. Cond. index score	2.6	3.3	6.2	-2.5	-2.1	2.5	0.2	-0.2
Pavlov. Cond. latency score	2.3	2.8	5.4	-2.2	-1.9	2.3	-0.0	0.0
Pavlov. Cond. lever contacts	0.5	0.7	1.6	-1.1	-0.7	1.3	0.2	-0.2
Pavlov. Cond. magazine entry number	5.5	6.7	11.1	3.3	3.1	-3.1	-1.3	1.3
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.7	1.1	1.3	-0.9	-0.8	0.8
Pavlov. Cond. lever-magazine prob. diff.	2.9	3.8	6.7	-2.6	-2.3	2.6	0.4	-0.4
Pavlov. Cond. response bias	1.7	2.3	4.3	-2.0	-1.6	2.1	0.5	-0.5
Time in closed arm before self-admin	0.5	0.6	1.0	-0.8	-0.5	1.0	-0.7	0.7
Time in closed arm after self-admin	0.1	0.1	0.2	0.5	0.3	-0.5	0.0	-0.0
Time in open arm before self-admin	1.7	1.9	4.8	1.7	1.0	-2.2	0.6	-0.6
Time in open arm after self-admin	0.4	0.4	0.8	0.7	0.6	-0.9	0.5	-0.5
Bone: periosteal estimation	1.2	2.5	5.0	-0.8	-0.4	1.3	-2.2	2.2
Bone: periosteal perimeter	0.9	1.5	2.0	-1.0	-0.7	1.4	-1.4	1.4
Bone: post-yield work	6.4	8.8	10.5	-2.8	-2.4	3.2	-3.1	3.1
Progressive ratio test 1 active lever presses	1.9	2.0	3.0	1.5	1.7	-1.1	-1.3	1.3
Progressive ratio test 1 breakpoint	1.9	2.0	2.9	1.5	1.7	-1.1	-1.3	1.3
Progressive ratio test 1 inactive lever presses	0.8	0.9	1.5	1.2	1.2	-1.2	-0.2	0.2
Progressive ratio test 2 active lever presses	2.4	2.6	4.2	1.5	2.0	-0.9	-1.7	1.7
Progressive ratio test 2 breakpoint	3.2	3.6	6.6	2.1	2.6	-1.5	-1.5	1.5
Progressive ratio test 2 inactive lever presses	3.6	4.1	8.7	2.2	2.9	-1.6	-1.5	1.5
Incentive Sensitization - Responses	0.3	0.3	0.6	0.2	0.5	0.1	-0.7	0.7
Incentive Sensitization - Breakpoint	0.4	0.4	0.6	0.3	0.7	-0.0	-0.8	0.8
Sum of active levers in priming session hrs 5-6	2.1	2.1	3.6	-1.5	-0.9	1.9	1.3	-1.3
Progressive ratio	2.9	3.4	6.0	-2.5	-2.3	2.3	-0.3	0.3
Food seeking constrained by brief footshock	0.3	0.3	0.7	0.3	-0.0	-0.5	0.8	-0.8
Seeking ratio, punishment vs. effort	3.3	4.1	7.8	2.7	2.2	-2.8	0.5	-0.5
Retroperitoneal fat weight	4.4	14.4	19.3	3.5	3.7	-2.8	-4.4	4.4
Reaction time number correct	0.2	0.3	0.6	-0.3	-0.0	0.3	0.8	-0.8
Reaction time mean minus median	3.3	4.3	7.9	-2.8	-2.2	2.8	0.8	-0.8
Reaction time mean minus median AUC	1.6	2.0	3.4	-1.8	-1.4	1.8	0.9	-0.9
Reaction time num false alarms	1.0	1.3	3.1	1.5	1.0	-1.8	0.4	-0.4
Reaction time num false alarms AUC	0.6	0.8	1.4	0.9	0.4	-1.2	0.9	-0.9
Reaction time trials correct on left	0.2	0.3	0.6	-0.3	-0.0	0.3	0.8	-0.8
Reaction time trials on left	0.2	0.3	0.8	-0.3	-0.1	0.3	0.9	-0.9
Reaction time mean	0.2	0.3	0.7	-0.8	-0.4	0.8	0.3	-0.3
Reaction time mean AUC	0.3	0.4	0.8	-0.8	-0.5	0.9	0.3	-0.3
Median of all reaction times	0.0	0.1	0.1	-0.3	-0.1	0.4	0.1	-0.1
Reaction time omissions	1.4	1.9	2.4	-1.4	-1.2	1.2	1.6	-1.6
Reaction time false alarm rate	0.6	0.8	2.0	1.2	0.7	-1.4	0.1	-0.1
Reaction time premature initiation rate	0.8	1.1	1.7	-0.7	-1.1	0.2	1.3	-1.3
Reaction time premature initiations	1.8	2.6	4.9	-1.1	-1.3	0.6	2.2	-2.2
Std. dev. reaction times	1.1	1.5	2.7	-1.6	-1.2	1.7	0.7	-0.7
Reaction time trials completed	0.2	0.3	0.8	-0.3	-0.1	0.3	0.9	-0.9
Reaction time trials AUC	0.1	0.2	0.4	-0.1	0.1	0.1	0.6	-0.6
Run reversals in cocaine runway, females	0.3	0.3	0.7	-0.4	-0.9	0.1	-0.5	0.5
Run reversals in cocaine runway, males	0.7	0.6	1.2	1.1	1.0	-0.9	0.2	-0.2
Latency to leave start box in cocaine runway	0.6	0.7	1.5	-0.4	-0.3	0.4	-1.2	1.2
Latency to leave start box in cocaine runway, F	0.3	0.3	0.4	-0.5	-0.5	0.4	-0.7	0.7
Latency to leave start box in cocaine runway, M	0.3	0.3	0.7	0.0	0.1	0.2	-0.9	0.9
Std. dev. time between licks in bursts	0.8	0.9	1.9	1.2	0.8	-1.4	0.5	-0.5
Total sessions with >9 infusions	1.8	2.0	3.2	1.2	1.2	-0.9	-1.8	1.8
Short access day 1 total inactive lever presses	2.2	2.5	4.8	2.0	2.2	-1.7	-0.5	0.5
Short access day 10 total inactive lever presses	3.3	3.7	6.4	2.5	2.4	-2.5	0.3	-0.3
Short access day 1 total infusions	2.8	3.0	5.9	1.1	1.2	-0.9	-2.4	2.4
Short access day 10 total infusions	2.1	2.4	5.7	0.3	0.6	0.0	-2.4	2.4
Short access total infusions	1.6	1.8	3.8	0.7	0.8	-0.4	-2.0	2.0
Short access day 1 locomotion	1.6	1.7	2.2	1.2	1.3	-1.0	-1.5	1.5
Short access day 10 total locomotion	1.1	1.2	1.9	0.8	1.0	-0.7	-1.4	1.4
Short access total locomotion	0.8	0.8	1.1	0.8	0.8	-0.7	-1.1	1.1
One hour access (0.3 mA shock)	6.0	7.1	12.5	2.9	3.5	-2.3	-2.1	2.1
Compulsive drug intake	0.8	0.8	1.6	-0.5	-1.3	-0.1	1.1	-1.1
One hour access (shock baseline)	4.0	4.6	9.7	2.1	3.1	-1.2	-1.9	1.9
Social response proportion	0.9	0.9	1.5	-1.2	-1.0	1.2	0.6	-0.6
Social responses	0.3	0.4	1.0	-0.2	-0.3	0.2	1.0	-1.0
Social time	0.3	0.4	1.0	-0.2	-0.4	0.2	1.0	-1.0
Soleus weight	2.9	8.5	10.9	3.3	3.3	-2.9	-2.5	2.5
Bone: stiffness	3.4	5.4	9.6	-3.0	-2.8	3.1	-0.5	0.5
Tibialis anterior weight	6.5	22.3	32.8	-5.7	-5.6	5.4	3.0	-3.0
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.4	-1.1	-1.0	1.2	-0.1	0.1
Time to tail flick, vehicle, after self-admin	0.8	0.9	2.0	-1.1	-1.4	0.9	-0.3	0.3
Time to tail flick, test, before self-admin	0.9	0.8	1.5	0.6	0.5	-0.6	-1.2	1.2
Time to tail flick, test, after self-admin	0.0	0.0	0.0	-0.0	-0.0	0.0	0.2	-0.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.4	-0.4	-0.6	0.2	-0.1	0.1
Delta time to tail flick, test, before/after SA	1.5	1.3	2.6	-0.7	-0.7	0.7	1.6	-1.6
Tibia length	1.3	3.6	8.7	-2.5	-1.7	2.9	0.2	-0.2
Ambulatory time before self-admin	1.0	1.0	2.5	-1.3	-0.9	1.6	-0.1	0.1
Ambulatory time after self-admin	0.3	0.3	0.6	-0.4	-0.1	0.6	-0.7	0.7
Bone: tissue strength	0.1	0.1	0.3	-0.5	-0.3	0.6	-0.2	0.2
Total heroin consumption	4.3	5.0	8.0	-2.6	-2.8	2.3	1.6	-1.6
Bone: trabecular number	1.4	2.1	3.3	-1.7	-1.4	1.8	-1.1	1.1
Bone: trabecular spacing	0.7	0.9	1.8	1.1	0.8	-1.3	0.7	-0.7
Bone: trabecular thickness	0.4	0.5	1.2	0.2	0.3	-0.1	-1.1	1.1
Bone: trabecular tissue density	2.1	2.9	5.0	2.1	2.2	-1.8	-1.0	1.0
Water consumed over 24 hours	1.3	1.5	3.4	-0.6	-0.7	0.2	1.8	-1.8
Number of responses in last shaping day	1.5	1.5	2.5	1.6	1.6	-1.6	0.2	-0.2