Hub : Genes

Cdca5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL alternative polyA XM_008760176.3 0.05 0.03 2.5e-05 0.05 0.04 0.04 0.04 6.6e-06 1.0e-05 2.0e-05 1.1e-05
2 NAcc alternative polyA XM_008760176.3 0.05 0.03 1.4e-07 0.03 0.05 0.05 0.05 2.1e-05 9.9e-08 4.9e-08 1.3e-07
3 pVTA alternative polyA NM_001115042.2 0.03 0.02 5.7e-03 0.01 0.02 0.02 0.01 2.7e-02 5.0e-03 1.2e-02 2.7e-02
4 pVTA alternative polyA XM_008760176.3 0.04 0.02 5.3e-03 0.01 0.02 0.02 0.01 4.2e-02 4.9e-03 1.3e-02 2.8e-02
5 IC alternative polyA XM_008760176.3 0.13 0.08 1.1e-03 0.03 0.03 0.01 0.02 2.5e-02 2.3e-02 8.5e-02 3.9e-02
6 RMTg alternative TSS NM_001115042.2 0.13 0.08 9.2e-03 0.16 0.09 0.13 0.15 5.1e-05 2.5e-03 2.5e-04 8.3e-05
7 RMTg alternative TSS XM_008760177.4 0.12 0.08 9.4e-03 0.17 0.08 0.14 0.16 3.7e-05 3.5e-03 1.2e-04 6.8e-05
8 OFC alternative TSS NM_001115042.2 0.24 0.21 4.7e-03 0 0.01 0.05 -0.01 2.4e-01 1.9e-01 3.0e-02 7.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.01.83.00.91.71.5-1.6-1.7-1.31.30.3
Area under the delay curve0.20.30.9-0.00.40.4-0.5-0.9-0.50.5-0.9
BMI with tail3.110.821.42.34.24.0-4.2-4.6-1.91.91.1
BMI without tail0.73.99.91.62.22.5-2.7-3.1-0.40.40.6
Body weight2.711.819.43.83.94.4-4.4-4.10.1-0.13.2
Weight adjusted by age0.51.42.61.51.21.2-1.1-0.41.1-1.11.6
Bone surface3.67.014.83.13.93.3-3.4-2.5-0.70.71.4
Bone volume1.73.48.21.82.92.2-2.2-1.7-1.21.20.3
Breakpoint value in progressive ratio session1.42.64.92.02.22.0-2.0-1.30.7-0.71.0
Number of licking bursts0.10.20.50.60.70.6-0.6-0.30.1-0.10.2
Context. condit. distance diff. score1.11.42.6-1.6-1.4-1.31.30.6-1.01.0-1.0
Locomotion velocity, session 10.10.20.50.1-0.60.00.0-0.20.5-0.50.7
Locomotion distance, session 10.91.23.10.80.91.3-1.4-1.8-0.40.40.9
Locomotion velocity, session 22.52.94.92.02.02.2-2.2-2.1-0.10.11.3
Locomotion distance, session 21.01.43.21.01.01.4-1.5-1.8-0.00.01.2
Locomotion velocity, session 30.70.82.6-0.4-0.10.2-0.3-0.9-1.61.60.2
Locomotion distance, session 30.00.00.1-0.2-0.2-0.10.1-0.1-0.20.20.2
Stereotopy head waving bouts, day 30.70.82.3-0.8-0.5-0.10.0-0.8-1.51.50.6
Stereotopy head waving duration, day 30.40.51.4-0.9-0.5-0.50.4-0.1-1.21.2-0.2
Locomotion velocity, session 70.91.02.9-0.60.30.2-0.3-1.0-1.71.7-0.5
Locomotion distance, session 70.30.31.2-0.2-0.10.4-0.5-1.1-0.60.60.6
Stereotopy head waving bouts, day 70.30.30.7-0.10.80.1-0.2-0.1-0.90.9-0.6
Stereotopy head waving duration, day 70.70.93.01.01.71.1-1.2-0.8-0.20.2-0.2
Locomotion velocity, session 80.91.14.51.10.10.9-0.8-0.80.7-0.72.1
Locomotion distance, session 80.40.62.0-0.5-0.00.0-0.1-0.7-1.41.40.2
Degree of sensitization distance0.40.41.10.00.20.5-0.6-1.0-0.80.80.6
Degree of sensitization stereotypy0.50.52.10.71.50.8-0.8-0.3-0.30.3-0.5
Conditioned locomotion1.11.32.11.51.01.4-1.3-1.10.7-0.71.4
Cocaine response after cond. corrected0.60.92.4-1.4-1.6-1.11.00.3-0.60.60.0
Cocaine response after cond. not corrected0.50.71.6-1.2-1.3-0.90.90.2-0.70.70.2
Cocaine response before conditioning0.40.51.50.91.20.8-0.8-0.20.4-0.40.2
Saline control response3.14.26.42.51.82.4-2.3-1.91.4-1.42.5
Bone: connectivity density2.43.97.22.02.72.5-2.5-2.3-0.60.61.0
Bone: cortical apparent density0.30.51.70.3-0.2-0.00.10.41.3-1.3-0.2
Bone: cortical area0.40.71.51.11.21.0-1.0-0.5-0.30.30.5
Bone: cortical porosity0.20.20.40.50.60.6-0.7-0.7-0.10.1-0.1
Bone: cortical porosity0.60.61.10.90.91.0-1.1-1.0-0.00.00.4
Bone: cortical thickness1.82.95.02.21.01.6-1.4-0.82.1-2.11.8
Bone: cortical thickness0.60.72.00.7-0.50.4-0.3-0.31.4-1.41.0
Bone: cortical tissue density0.40.62.20.5-0.10.1-0.00.31.5-1.5-0.1
Condit. Reinf. active minus inactive responses0.20.20.50.40.50.6-0.6-0.70.2-0.2-0.1
Condit. Reinf. active-inactive response ratio0.10.20.40.10.20.1-0.1-0.00.6-0.6-0.6
Condit. Reinf. active responses0.20.30.50.10.50.4-0.5-0.6-0.70.7-0.1
Condit. Reinf. inactive responses0.60.82.8-0.30.40.1-0.2-0.5-1.71.70.2
Incentive salience index mean0.50.71.60.51.01.0-1.1-1.3-0.40.4-0.0
Condit. Reinf. lever presses0.71.01.80.71.31.1-1.2-1.1-1.01.00.3
Condit. Reinf. active minus inactive responses0.20.30.7-0.20.3-0.20.20.4-0.70.7-0.9
Condit. Reinf. active-inactive response ratio0.81.33.8-0.80.1-0.60.50.6-2.02.0-1.0
Condit. Reinf. active responses0.10.20.60.40.80.4-0.4-0.2-0.00.0-0.7
Condit. Reinf. inactive responses0.50.81.20.80.70.9-0.9-0.91.1-1.10.1
Condit. Reinf. lever presses1.11.74.21.72.11.6-1.6-0.80.0-0.00.4
Condit. Reinf. lever reinforcers received0.20.30.90.71.00.6-0.6-0.20.3-0.3-0.4
Conditioned reinforcement - actives0.10.31.4-0.10.4-0.40.41.2-0.20.20.2
Conditioned reinforcement - inactives1.23.36.3-2.1-1.2-2.32.32.5-0.90.9-1.5
Conditioned locomotion5.48.013.3-3.3-2.8-3.73.63.4-1.01.0-2.2
Patch foraging indifference point 0 sec0.00.00.1-0.30.0-0.10.0-0.0-0.10.1-0.0
Patch foraging indifference point AUC0.92.14.02.01.81.4-1.4-0.41.5-1.51.1
Delay disc. indifference point, 0s delay0.50.51.0-0.40.20.2-0.3-1.0-1.01.0-1.0
Delay disc. indifference point, 16s delay0.40.61.9-0.8-0.2-0.60.50.3-0.80.8-1.4
Delay disc. indifference point, 2s delay0.40.41.1-0.30.40.0-0.1-0.3-1.11.1-1.0
Delay disc. indifference point, 24s delay0.10.10.3-0.2-0.5-0.20.20.00.5-0.50.2
Delay disc. indifference point, 4s delay0.10.20.9-0.20.00.3-0.3-0.9-0.30.3-0.2
Delay disc. indifference point, 8s delay0.10.10.60.1-0.10.3-0.3-0.8-0.20.2-0.5
Indifference point function ln k2.68.014.2-3.8-3.6-3.13.01.5-2.42.4-2.1
Indifference point function log k2.68.014.2-3.8-3.6-3.13.01.5-2.42.4-2.1
Patch foraging total patch changes 0 sec0.00.10.2-0.2-0.3-0.10.10.10.3-0.30.4
Patch foraging total patch changes 12 sec3.44.66.62.62.42.5-2.4-1.81.7-1.71.8
Patch foraging total patch changes 18 sec0.30.71.81.01.31.0-1.0-0.70.2-0.20.7
Patch foraging total patch changes 24 sec0.62.13.51.81.11.3-1.2-0.61.6-1.61.9
Patch foraging total patch changes 6 sec0.71.21.71.21.01.3-1.3-1.20.6-0.61.2
Patch foraging time to switch 0 sec0.93.68.31.72.92.4-2.5-2.3-0.60.60.5
Patch foraging water rate 0 sec1.87.013.4-2.6-3.7-3.43.43.1-0.70.7-1.4
Patch foraging water rate 12 sec2.911.825.6-3.7-5.1-4.44.43.4-1.01.0-1.9
Patch foraging water rate 18 sec1.53.28.0-2.1-2.8-2.22.21.4-0.80.8-0.6
Patch foraging water rate 24 sec3.85.411.1-2.4-3.3-2.92.92.3-1.31.3-1.1
Patch foraging water rate 6 sec4.05.915.3-2.5-3.9-3.03.02.2-1.01.0-0.9
Seeking ratio, delayed vs. immediate footshock0.00.10.2-0.40.1-0.0-0.1-0.4-0.10.1-0.4
Distance traveled before self-admin0.40.92.90.91.71.1-1.1-0.7-0.40.4-0.1
Distance traveled after self-admin0.20.30.50.50.70.4-0.40.00.5-0.5-0.7
Extensor digitorum longus weight5.823.335.15.95.35.9-5.8-4.72.5-2.54.6
Bone: elastic displacement1.31.75.1-1.0-2.2-1.51.61.20.6-0.60.5
Bone: elastic work0.91.13.41.0-0.20.8-0.7-0.81.2-1.21.8
Bone: endosteal estimation1.33.111.1-1.20.3-0.20.0-0.6-3.33.3-0.7
Bone: endosteal perimeter1.63.913.1-1.40.4-0.50.3-0.1-3.63.6-1.4
Epididymis fat weight1.89.313.1-3.3-2.3-3.23.02.6-3.63.6-2.5
Delta time in closed arm before/after self-admin0.60.51.50.3-0.60.5-0.5-1.00.6-0.61.2
Delta time in open arm before/after self-admin0.20.31.10.41.00.2-0.20.6-0.00.0-0.7
Diff in mean of infusions in LGA sessions0.30.50.90.80.60.7-0.6-0.40.8-0.80.9
Delay discount exponential model param0.20.20.7-0.0-0.4-0.40.50.80.3-0.30.7
Extinction: sum of active levers before priming1.92.85.21.62.32.0-2.1-1.80.7-0.71.4
Active lever presses in extinction session 62.22.24.62.02.21.8-1.7-0.90.4-0.41.5
Bone: final force1.82.94.72.12.12.2-2.2-1.6-0.10.11.5
Bone: final moment1.72.74.42.12.02.1-2.1-1.6-0.00.01.4
Food consumed during 24 hour testing period0.10.31.00.3-0.0-0.30.41.00.6-0.6-0.2
Glucose1.62.66.0-2.0-0.9-1.10.9-0.2-2.42.4-1.3
Heart weight1.11.75.0-1.1-0.3-0.0-0.2-1.5-2.22.2-0.1
Delay discount hyperbolic model param0.20.30.7-0.0-0.5-0.40.50.80.5-0.50.8
Intermittent access intake day 1-15 change0.31.63.9-1.4-0.9-1.71.72.0-0.20.2-0.6
Intermittent access intake escalation0.31.54.0-1.3-0.8-1.61.62.0-0.20.2-0.5
Intermittent access intake escalation 20.81.33.6-1.2-0.7-1.51.51.9-0.20.2-0.7
Intermitt. access day 1 inactive lever presses0.00.61.6-0.4-0.3-0.50.60.61.3-1.3-0.3
Intermitt. access day 15 inactive lever presses0.31.72.8-1.7-0.7-1.61.51.5-0.90.9-1.3
Intermitt. access escalation Index1.13.36.4-2.0-1.5-1.71.60.8-2.02.0-2.5
Intermittent access day 1 total infusions1.23.49.2-1.9-0.2-1.10.80.2-3.03.0-1.9
Intermittent access day 15 total infusions2.25.48.2-2.9-1.4-2.72.52.4-2.22.2-1.9
Intermittent access terminal intake (last 3 days)2.85.08.0-2.6-0.9-2.22.01.9-2.82.8-2.0
Intermittent access total infusions3.13.77.8-2.2-0.6-1.71.51.1-2.82.8-1.6
Intermittent access day 1 locomotion0.91.73.6-1.6-0.3-1.00.90.4-1.91.9-1.3
Intermittent access day 15 total locomotion1.14.46.3-2.5-0.8-2.32.22.2-2.22.2-2.0
Intermittent access total locomotion5.66.711.5-2.9-0.7-2.42.21.9-3.43.4-2.8
Intermittent access standard deviation0.31.52.9-1.4-1.2-1.71.71.70.1-0.1-0.4
Left kidney weight0.32.55.5-1.7-0.5-1.21.00.6-2.42.4-1.9
Right kidney weight0.21.31.7-1.1-0.8-1.21.11.0-1.31.3-1.2
Cocaine induced anxiety0.00.10.3-0.00.50.1-0.10.20.3-0.30.0
Post-drug Anxiety0.40.50.90.70.90.8-0.8-0.40.4-0.40.7
Baseline Anxiety0.30.40.90.6-0.10.6-0.5-0.60.8-0.81.0
Tail length0.42.04.71.50.10.8-0.7-0.32.2-2.21.8
Length with tail1.46.413.23.11.62.6-2.4-1.72.2-2.23.6
Length without tail0.84.410.52.71.12.2-2.0-1.51.6-1.63.2
Times rat made contact with spout0.50.60.90.70.50.8-0.8-0.80.9-0.90.3
Lifetime Intake2.12.76.0-1.9-0.6-1.31.20.7-2.52.5-1.3
Liver weight, left0.61.02.1-1.1-1.4-1.11.10.6-1.01.00.2
Liver weight, right1.22.25.2-2.1-2.3-1.71.70.6-0.80.80.4
Locomotor activity1.92.98.4-1.9-2.9-2.22.21.5-0.10.1-0.1
Locomotor testing distance1.53.811.7-2.0-3.4-2.42.41.6-0.10.1-0.0
Locomotor testing rearing0.83.08.2-2.0-2.9-2.12.21.40.1-0.1-0.6
Locomotion in novel chamber3.74.97.4-2.7-2.1-2.62.52.0-2.02.0-1.5
Locomotion in novel chamber post-restriction1.23.75.8-2.2-1.4-2.12.11.8-1.61.6-2.4
Fecal boli incidents, locomotor time 10.10.20.90.10.90.0-0.00.5-0.50.5-0.4
Change in fecal boli incidents, locomotor task0.30.30.8-0.0-0.60.3-0.3-0.9-0.10.10.9
Time >=10cm from walls, locomotor time 11.31.65.7-0.80.9-0.1-0.0-0.2-2.42.4-0.6
Bouts of movement, locomotor time 11.62.05.41.61.10.9-0.70.12.3-2.3-0.6
Total resting periods, locomotor time 11.21.33.31.31.10.7-0.60.21.8-1.8-0.7
Rest time, locomotor task time 10.91.52.3-1.2-1.2-1.51.51.4-0.70.7-1.1
Distance moved, locomotor task time 10.20.61.30.30.90.8-0.9-1.1-0.80.80.1
Vertical activity count, locomotor time 10.10.81.4-1.2-1.0-1.01.00.6-0.80.8-0.4
Time >=10cm from walls, locomotor time 20.00.10.70.30.80.2-0.20.3-0.00.0-0.2
Bouts of movement, locomotor time 20.20.51.00.70.70.6-0.6-0.31.0-1.0-0.6
Total resting periods, locomotor time 20.10.31.00.40.60.5-0.4-0.20.6-0.6-1.0
Rest time, locomotor task time 21.42.44.6-1.6-1.4-1.51.40.9-1.51.5-2.1
Distance moved, locomotor task time 20.91.21.61.20.91.0-0.9-0.51.3-1.31.3
Vertical activity count, locomotor time 20.41.02.8-0.1-1.2-0.60.70.71.1-1.11.7
Light reinforcement 10.10.20.4-0.4-0.5-0.50.60.60.5-0.5-0.3
Light reinforcement 20.61.32.1-1.0-0.3-1.21.11.4-1.31.3-1.1
Bone: marrow area1.33.211.5-1.30.2-0.30.1-0.7-3.43.4-0.7
Bone: maximum diameter0.30.61.50.51.10.5-0.5-0.0-1.21.20.1
Bone: maximum force2.75.39.92.53.22.9-3.0-2.4-0.80.81.4
Bone: maximum moment2.64.99.02.43.02.8-2.8-2.4-0.80.81.4
Mean time between licks in bursts0.10.72.40.5-0.40.5-0.4-0.81.0-1.01.6
Mean num. licks in bursts0.10.20.4-0.5-0.7-0.40.40.10.4-0.4-0.3
Cd content in liver1.31.53.8-1.2-0.4-1.31.21.4-0.90.9-1.9
Co content in liver2.02.45.5-1.2-2.3-1.71.81.51.3-1.3-0.5
Cu content in liver0.10.10.4-0.20.30.1-0.2-0.30.0-0.0-0.6
Fe content in liver0.40.53.40.4-0.00.2-0.2-0.1-0.00.01.8
K content in liver1.01.02.10.60.91.1-1.2-1.4-0.80.80.9
Mg content in liver0.30.41.0-0.7-0.5-0.20.1-0.4-1.01.0-0.1
Mn content in liver2.12.44.32.12.01.8-1.8-1.00.4-0.41.7
Na content in liver0.20.31.00.70.20.4-0.30.10.4-0.41.0
Rb content in liver1.31.52.8-1.6-1.7-1.41.30.5-1.01.0-1.1
Se content in liver0.30.41.0-0.40.1-0.50.50.7-1.01.0-0.4
Sr content in liver1.51.32.91.71.21.2-1.0-0.31.3-1.30.5
Zn content in liver0.30.30.50.50.70.7-0.7-0.70.5-0.50.1
Bone: minimum diameter1.52.88.8-1.20.5-0.1-0.1-0.8-3.03.0-1.6
Time in familiar zone, hab. session 10.20.30.7-0.6-0.1-0.20.2-0.2-0.90.9-0.4
Time in novel zone, hab. session 10.40.41.5-0.4-1.2-0.60.70.50.5-0.50.3
Total zone transitions, hab. session 10.50.81.11.01.01.1-1.1-0.90.6-0.60.4
Total locomotion distance, hab. session 10.20.31.1-0.50.0-0.10.0-0.4-1.01.0-0.3
Locomotion velocity, hab. session 10.10.20.3-0.00.40.3-0.4-0.6-0.50.50.1
Time in familiar zone, hab. session 20.30.31.7-0.2-0.8-0.20.2-0.10.4-0.41.3
Time in novel zone, hab. session 20.20.31.00.40.70.4-0.5-0.3-0.10.1-1.0
Total zone transitions, hab. session 22.12.75.81.41.92.1-2.2-2.4-0.40.40.7
Total locomotion distance, hab. session 20.71.02.6-0.00.70.8-1.0-1.6-1.21.20.1
Locomotion velocity, hab. session 20.81.12.4-0.20.70.7-0.8-1.4-1.61.6-0.2
Novel to familiar place preference ratio0.70.93.11.21.81.1-1.1-0.40.3-0.3-0.4
Novelty place preference0.40.51.90.81.40.7-0.7-0.10.2-0.2-0.7
Time in novel zone, NPP test0.30.41.30.71.20.6-0.6-0.10.2-0.2-0.6
Total zone transitions, NPP test2.03.05.02.02.12.2-2.2-2.00.3-0.31.2
Total locomotion distance, NPP test0.40.51.40.30.60.8-0.8-1.2-0.60.60.1
Locomotion velocity, NPP test0.30.41.20.40.70.8-0.9-1.1-0.40.4-0.0
Intraocular pressure1.21.95.5-1.2-0.9-1.81.82.30.3-0.3-0.8
Delta distance traveled before/after self-admin0.60.61.5-0.4-1.2-0.60.70.51.0-1.0-0.2
Delta ambulatory time before/after self-admin0.30.51.3-0.2-1.0-0.40.50.31.2-1.20.1
Parametrial fat weight2.45.78.8-2.9-1.3-2.32.11.3-3.03.0-2.6
Pavlov. Cond. lever latency0.40.50.9-0.6-0.8-0.90.90.90.4-0.4-0.5
Pavlov. Cond. magazine entry latency0.70.92.00.51.41.1-1.1-1.1-0.60.6-0.6
Pavlov. Cond. change in total contacts0.50.51.50.31.20.5-0.6-0.3-0.50.5-1.2
Pavlov. Cond. index score0.20.30.90.50.90.7-0.7-0.4-0.10.1-0.3
Pavlov. Cond. latency score0.20.30.70.40.80.7-0.7-0.7-0.30.3-0.1
Pavlov. Cond. lever contacts0.30.40.80.30.60.7-0.7-0.9-0.60.60.2
Pavlov. Cond. magazine entry number0.20.30.9-0.6-0.9-0.60.50.0-0.30.30.6
Pavlov. Cond. intertrial magazine entries0.80.91.8-0.9-0.7-1.21.21.30.0-0.0-1.2
Pavlov. Cond. lever-magazine prob. diff.0.40.61.60.61.30.9-1.0-0.7-0.10.1-0.4
Pavlov. Cond. response bias0.20.20.60.50.80.5-0.5-0.20.1-0.1-0.4
Pavlov. Cond. lever latency0.30.51.4-1.0-1.2-0.80.70.20.3-0.3-0.3
Pavlov. Cond. magazine entry latency2.94.18.12.42.92.6-2.6-1.90.9-0.90.9
Pavlov. Cond. change in total contacts0.81.86.41.62.51.6-1.6-0.70.1-0.1-0.4
Pavlov. Cond. index score1.62.56.62.02.62.0-2.0-1.20.2-0.20.4
Pavlov. Cond. latency score1.32.15.91.82.41.8-1.8-1.1-0.00.00.4
Pavlov. Cond. lever contacts0.30.51.51.01.20.8-0.8-0.2-0.20.20.3
Pavlov. Cond. magazine entry number4.86.212.1-3.2-3.5-3.13.01.9-1.41.4-1.1
Pavlov. Cond. intertrial magazine entries0.51.21.7-1.3-1.1-1.31.21.0-0.90.9-0.8
Pavlov. Cond. lever-magazine prob. diff.1.92.97.52.22.72.1-2.1-1.30.4-0.40.5
Pavlov. Cond. response bias1.42.05.01.92.21.8-1.8-1.00.2-0.20.5
Time in closed arm before self-admin0.20.30.6-0.50.3-0.40.30.5-0.80.8-0.3
Time in closed arm after self-admin0.20.20.5-0.6-0.7-0.40.4-0.1-0.20.20.2
Time in open arm before self-admin0.50.62.3-0.4-1.5-0.30.3-0.50.9-0.90.3
Time in open arm after self-admin0.10.10.30.3-0.10.2-0.1-0.10.5-0.5-0.2
Bone: periosteal estimation0.71.65.3-0.01.00.5-0.6-0.7-2.32.3-0.2
Bone: periosteal perimeter0.51.12.60.41.20.7-0.8-0.7-1.61.6-0.1
Bone: post-yield work3.86.611.10.83.32.2-2.5-2.6-3.33.3-1.2
Progressive ratio test 1 active lever presses0.20.30.5-0.6-0.2-0.60.50.7-0.70.7-0.7
Progressive ratio test 1 breakpoint0.20.30.4-0.5-0.1-0.50.50.7-0.60.6-0.6
Progressive ratio test 1 inactive lever presses0.10.30.6-0.3-0.1-0.40.40.70.8-0.8-0.3
Progressive ratio test 2 active lever presses1.62.33.3-1.8-0.8-1.81.71.7-1.41.4-1.3
Progressive ratio test 2 breakpoint1.82.33.2-1.8-0.8-1.81.71.8-1.41.4-1.3
Progressive ratio test 2 inactive lever presses2.47.711.6-3.4-1.9-3.33.12.9-2.22.2-2.8
Incentive Sensitization - Responses0.10.41.2-0.20.60.1-0.2-0.1-1.11.1-0.0
Incentive Sensitization - Breakpoint0.20.31.2-0.40.4-0.10.00.1-1.11.1-0.1
Sum of active levers in priming session hrs 5-61.11.02.11.00.80.10.11.41.2-1.21.3
Progressive ratio1.03.06.31.22.52.1-2.2-2.2-1.01.00.8
Food seeking constrained by brief footshock0.20.31.30.2-0.10.2-0.2-0.40.5-0.51.2
Seeking ratio, punishment vs. effort1.22.77.2-1.4-2.7-2.02.01.60.9-0.9-0.4
Retroperitoneal fat weight6.127.344.8-6.7-5.6-6.15.83.9-4.54.5-4.0
Reaction time number correct0.10.31.00.8-0.00.2-0.20.10.5-0.51.0
Reaction time mean minus median0.63.67.22.32.72.3-2.2-1.31.3-1.31.3
Reaction time mean minus median AUC0.32.02.81.71.61.4-1.4-0.61.5-1.51.3
Reaction time num false alarms0.30.62.5-0.8-1.6-0.70.7-0.00.4-0.40.5
Reaction time num false alarms AUC0.20.51.1-0.2-0.9-0.00.1-0.50.9-0.91.0
Reaction time trials correct on left0.10.31.00.8-0.00.2-0.20.10.5-0.51.0
Reaction time trials on left0.10.41.30.90.00.3-0.20.10.6-0.61.1
Reaction time mean0.10.20.40.40.60.2-0.20.30.6-0.6-0.5
Reaction time mean AUC0.10.20.50.30.70.2-0.20.20.6-0.6-0.6
Median of all reaction times0.10.21.0-0.20.1-0.30.30.50.2-0.2-1.0
Reaction time omissions1.42.23.31.81.51.5-1.5-0.91.7-1.71.1
Reaction time false alarm rate0.20.31.3-0.8-1.1-0.40.4-0.30.2-0.20.4
Reaction time premature initiation rate1.72.63.71.80.61.8-1.7-1.71.5-1.51.9
Reaction time premature initiations1.44.16.32.50.82.0-1.8-1.52.3-2.32.5
Std. dev. reaction times0.41.22.21.31.51.1-1.1-0.41.2-1.20.5
Reaction time trials completed0.10.41.30.90.00.3-0.20.10.6-0.61.1
Reaction time trials AUC0.10.31.10.7-0.20.2-0.10.10.5-0.51.0
Run reversals in cocaine runway, females1.11.24.50.60.71.3-1.4-2.1-0.60.60.2
Run reversals in cocaine runway, males0.80.91.9-0.5-1.4-1.11.21.30.1-0.1-0.4
Latency to leave start box in cocaine runway0.30.41.0-0.40.70.3-0.4-0.7-1.01.0-0.2
Latency to leave start box in cocaine runway, F0.10.20.4-0.10.60.2-0.3-0.5-0.30.3-0.7
Latency to leave start box in cocaine runway, M0.50.41.0-0.10.30.3-0.4-0.6-1.01.01.0
Std. dev. time between licks in bursts0.20.31.4-0.2-1.2-0.20.3-0.20.3-0.30.9
Total sessions with >9 infusions0.60.82.40.00.50.4-0.5-0.7-1.61.6-0.5
Short access day 1 total inactive lever presses0.81.63.2-1.8-1.5-1.61.50.9-0.50.5-0.8
Short access day 10 total inactive lever presses0.10.81.7-0.9-1.0-0.80.80.31.3-1.30.4
Short access day 1 total infusions0.81.63.7-1.3-0.6-0.90.70.1-1.91.9-1.3
Short access day 10 total infusions1.11.85.5-0.60.80.1-0.3-0.8-2.32.3-1.1
Short access total infusions0.71.03.5-0.60.1-0.1-0.1-0.6-1.91.9-0.3
Short access day 1 locomotion0.91.52.4-1.5-0.7-1.11.00.5-1.51.5-1.4
Short access day 10 total locomotion0.20.92.0-1.00.1-0.70.60.4-1.41.4-1.0
Short access total locomotion1.01.53.3-1.3-0.3-0.90.80.5-1.81.8-1.4
One hour access (0.3 mA shock)4.65.58.9-3.0-2.2-2.92.82.2-1.91.9-1.6
Compulsive drug intake1.31.93.21.6-0.21.2-1.0-1.11.8-1.81.6
One hour access (shock baseline)2.66.810.6-3.3-1.6-3.02.92.7-2.32.3-2.4
Social response proportion0.40.51.00.91.00.8-0.8-0.30.4-0.40.5
Social responses0.30.41.00.60.20.3-0.20.00.9-0.91.0
Social time0.50.71.90.9-0.00.4-0.3-0.11.2-1.21.4
Soleus weight2.98.614.1-3.8-3.3-3.53.42.3-2.32.3-2.3
Bone: stiffness2.03.68.12.12.92.4-2.4-1.8-0.60.60.7
Tibialis anterior weight6.923.840.76.44.95.5-5.3-3.43.6-3.65.4
Time to tail flick, vehicle, before self-admin0.40.50.90.50.90.8-0.8-0.8-0.50.50.4
Time to tail flick, vehicle, after self-admin1.12.25.20.81.61.7-1.8-2.3-1.01.01.0
Time to tail flick, test, before self-admin1.31.53.5-1.5-0.8-0.80.6-0.4-1.91.9-1.2
Time to tail flick, test, after self-admin0.00.00.20.30.40.1-0.10.30.0-0.00.0
Delta time to tail flick, vehicle, before/after SA0.60.71.80.60.81.0-1.1-1.3-0.20.20.7
Delta time to tail flick, test, before/after SA1.51.84.71.50.50.4-0.11.12.2-2.21.1
Tibia length0.51.34.41.82.11.2-1.10.2-0.30.30.5
Ambulatory time before self-admin0.20.72.80.71.70.9-0.9-0.4-0.60.6-0.2
Ambulatory time after self-admin0.20.42.2-0.40.4-0.30.30.4-0.40.4-1.5
Bone: tissue strength0.00.00.00.10.20.1-0.1-0.0-0.10.10.1
Total heroin consumption4.35.17.22.72.62.5-2.4-1.62.0-2.02.1
Bone: trabecular number1.01.94.51.12.11.5-1.6-1.4-1.11.10.0
Bone: trabecular spacing0.40.61.8-0.7-1.3-0.80.80.40.8-0.8-0.0
Bone: trabecular thickness0.40.51.2-0.60.0-0.30.2-0.1-1.11.1-1.0
Bone: trabecular tissue density2.64.67.4-2.6-2.3-2.72.72.3-1.01.0-1.7
Water consumed over 24 hours0.61.12.31.30.70.9-0.8-0.41.5-1.50.4
Number of responses in last shaping day0.10.20.5-0.1-0.5-0.20.30.20.7-0.70.2