Hub : Genes

LOC102554489

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr15_38820277_38825743 0.04 0.03 3.1e-04 0.02 0.02 0.02 0 9.0e-04 9.6e-04 1.9e-03 2.9e-01
2 NAcc intron excision ratio chr15_38820277_38826400 0.04 0.03 4.7e-04 0.02 0.02 0.03 0.02 1.4e-03 1.6e-03 5.0e-04 3.9e-03
3 Brain intron excision ratio chr15_38820277_38826400 0.07 0.05 8.7e-06 0.03 0.07 0.06 0.06 5.3e-04 8.6e-07 1.7e-06 1.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.71.21.81.0-1.01.3
Area under the delay curve7.17.59.9-2.42.6-3.1
BMI with tail2.27.310.3-2.33.2-2.5
BMI without tail0.10.20.30.40.50.2
Body weight1.77.19.0-3.02.8-2.0
Weight adjusted by age0.50.51.4-1.20.40.2
Bone surface0.40.80.90.7-0.90.9
Bone volume0.10.20.40.4-0.70.4
Breakpoint value in progressive ratio session1.21.41.8-0.81.3-1.3
Number of licking bursts1.01.11.8-0.71.3-1.0
Context. condit. distance diff. score0.40.51.41.20.4-0.0
Locomotion velocity, session 10.20.20.2-0.50.5-0.5
Locomotion distance, session 10.20.20.7-0.0-0.90.1
Locomotion velocity, session 20.30.30.7-0.4-0.1-0.9
Locomotion distance, session 20.50.71.70.4-1.30.5
Locomotion velocity, session 31.01.12.2-1.01.5-0.4
Locomotion distance, session 30.80.91.4-0.91.2-0.8
Stereotopy head waving bouts, day 30.50.61.20.4-0.71.1
Stereotopy head waving duration, day 30.20.30.7-0.80.30.1
Locomotion velocity, session 70.50.61.51.20.40.2
Locomotion distance, session 71.11.43.41.8-0.50.8
Stereotopy head waving bouts, day 71.01.12.1-1.40.7-0.8
Stereotopy head waving duration, day 71.61.93.5-1.91.2-0.8
Locomotion velocity, session 80.20.30.5-0.20.5-0.7
Locomotion distance, session 80.10.20.60.8-0.2-0.0
Degree of sensitization distance4.14.17.32.7-1.71.5
Degree of sensitization stereotypy1.31.42.0-1.40.9-1.2
Conditioned locomotion0.20.20.60.8-0.10.3
Cocaine response after cond. corrected0.50.61.00.11.0-0.9
Cocaine response after cond. not corrected0.50.60.9-0.10.9-0.9
Cocaine response before conditioning0.10.10.2-0.5-0.20.2
Saline control response0.10.10.4-0.1-0.60.1
Bone: connectivity density2.84.57.21.9-1.62.7
Bone: cortical apparent density0.70.92.2-0.41.5-0.6
Bone: cortical area1.52.34.0-1.31.0-2.0
Bone: cortical porosity1.61.72.8-1.71.0-1.2
Bone: cortical porosity1.11.22.0-1.40.7-1.0
Bone: cortical thickness3.04.97.1-2.01.9-2.7
Bone: cortical thickness3.64.28.1-1.31.7-2.8
Bone: cortical tissue density0.70.92.2-0.41.5-0.6
Condit. Reinf. active minus inactive responses0.10.10.3-0.50.2-0.1
Condit. Reinf. active-inactive response ratio0.10.10.20.2-0.20.5
Condit. Reinf. active responses0.30.30.5-0.70.5-0.4
Condit. Reinf. inactive responses0.10.10.2-0.40.3-0.3
Incentive salience index mean1.21.42.1-1.51.0-1.1
Condit. Reinf. lever presses1.82.43.2-1.81.3-1.6
Condit. Reinf. active minus inactive responses0.10.10.10.4-0.3-0.1
Condit. Reinf. active-inactive response ratio0.00.00.10.20.3-0.1
Condit. Reinf. active responses0.20.20.40.6-0.60.1
Condit. Reinf. inactive responses1.01.32.01.1-1.40.8
Condit. Reinf. lever presses0.20.30.6-0.0-0.80.6
Condit. Reinf. lever reinforcers received0.00.10.10.2-0.4-0.1
Conditioned reinforcement - actives7.67.69.73.1-2.62.5
Conditioned reinforcement - inactives2.32.63.01.7-1.31.7
Conditioned locomotion0.70.91.91.4-0.80.4
Patch foraging indifference point 0 sec0.50.82.1-0.1-1.40.4
Patch foraging indifference point AUC0.30.30.70.00.5-0.9
Delay disc. indifference point, 0s delay0.00.00.1-0.1-0.1-0.2
Delay disc. indifference point, 16s delay5.35.47.7-1.92.2-2.8
Delay disc. indifference point, 2s delay0.50.50.8-0.80.2-0.9
Delay disc. indifference point, 24s delay7.37.19.4-1.92.8-3.1
Delay disc. indifference point, 4s delay4.54.75.5-2.12.1-2.3
Delay disc. indifference point, 8s delay8.48.79.9-2.73.0-3.1
Indifference point function ln k0.10.20.5-0.7-0.1-0.0
Indifference point function log k0.10.20.5-0.7-0.1-0.0
Patch foraging total patch changes 0 sec0.30.51.3-0.5-1.20.1
Patch foraging total patch changes 12 sec0.20.20.3-0.6-0.1-0.6
Patch foraging total patch changes 18 sec0.10.10.30.4-0.50.0
Patch foraging total patch changes 24 sec0.30.31.0-0.2-1.0-0.0
Patch foraging total patch changes 6 sec0.00.00.0-0.20.1-0.2
Patch foraging time to switch 0 sec0.00.10.10.20.10.3
Patch foraging water rate 0 sec0.50.81.2-1.10.5-1.0
Patch foraging water rate 12 sec0.10.10.3-0.4-0.2-0.5
Patch foraging water rate 18 sec3.34.45.5-2.22.3-1.7
Patch foraging water rate 24 sec0.10.20.30.00.4-0.6
Patch foraging water rate 6 sec0.30.51.0-1.00.1-0.7
Seeking ratio, delayed vs. immediate footshock0.10.10.10.0-0.30.3
Distance traveled before self-admin1.01.12.50.6-1.60.6
Distance traveled after self-admin0.40.51.30.3-1.10.3
Extensor digitorum longus weight6.425.230.8-5.54.8-4.7
Bone: elastic displacement0.60.61.60.3-1.30.4
Bone: elastic work0.30.30.6-0.7-0.5-0.4
Bone: endosteal estimation0.10.20.30.4-0.50.4
Bone: endosteal perimeter0.91.82.91.1-1.71.2
Epididymis fat weight0.00.00.10.00.1-0.4
Delta time in closed arm before/after self-admin0.80.80.90.9-1.00.8
Delta time in open arm before/after self-admin0.00.00.00.20.20.0
Diff in mean of infusions in LGA sessions3.53.96.5-2.51.7-1.5
Delay discount exponential model param7.98.310.62.6-2.83.3
Extinction: sum of active levers before priming0.00.00.10.3-0.0-0.1
Active lever presses in extinction session 60.20.20.50.7-0.10.3
Bone: final force1.42.23.2-1.41.2-1.8
Bone: final moment1.01.72.2-1.40.9-1.5
Food consumed during 24 hour testing period0.10.10.2-0.0-0.50.4
Glucose0.30.40.8-0.30.6-0.9
Heart weight0.10.10.2-0.20.00.4
Delay discount hyperbolic model param7.68.010.02.6-2.73.2
Intermittent access intake day 1-15 change1.01.01.21.1-0.81.1
Intermittent access intake escalation0.80.81.11.1-0.60.9
Intermittent access intake escalation 20.40.40.70.7-0.20.8
Intermitt. access day 1 inactive lever presses0.91.01.61.0-0.51.3
Intermitt. access day 15 inactive lever presses0.50.51.5-0.00.31.2
Intermitt. access escalation Index0.10.10.20.5-0.3-0.1
Intermittent access day 1 total infusions0.10.10.30.6-0.2-0.2
Intermittent access day 15 total infusions1.01.12.31.5-0.60.7
Intermittent access terminal intake (last 3 days)0.70.81.91.4-0.40.6
Intermittent access total infusions0.70.72.01.4-0.50.3
Intermittent access day 1 locomotion0.20.20.6-0.3-0.1-0.7
Intermittent access day 15 total locomotion0.30.30.40.6-0.60.3
Intermittent access total locomotion0.10.10.10.0-0.3-0.4
Intermittent access standard deviation1.41.52.01.3-1.40.9
Left kidney weight0.92.53.7-1.91.9-0.4
Right kidney weight1.02.74.7-2.21.8-0.3
Cocaine induced anxiety0.10.10.3-0.5-0.2-0.0
Post-drug Anxiety0.30.40.6-0.3-0.80.7
Baseline Anxiety0.10.10.30.1-0.60.2
Tail length0.92.64.11.3-1.52.0
Length with tail0.10.40.9-1.00.10.4
Length without tail2.45.38.7-2.92.0-1.8
Times rat made contact with spout0.10.10.10.3-0.40.1
Lifetime Intake1.21.42.71.6-1.10.6
Liver weight, left2.13.44.3-2.12.0-1.4
Liver weight, right1.72.83.1-1.71.8-1.6
Locomotor activity1.11.84.3-2.10.5-0.8
Locomotor testing distance0.91.43.6-0.2-1.90.8
Locomotor testing rearing3.24.99.40.6-3.12.2
Locomotion in novel chamber0.81.01.5-1.01.2-0.7
Locomotion in novel chamber post-restriction0.30.40.8-0.40.3-0.9
Fecal boli incidents, locomotor time 10.20.20.3-0.60.5-0.4
Change in fecal boli incidents, locomotor task0.10.10.30.00.20.5
Time >=10cm from walls, locomotor time 10.60.61.00.2-0.91.0
Bouts of movement, locomotor time 10.00.00.1-0.1-0.1-0.3
Total resting periods, locomotor time 10.10.10.30.10.2-0.6
Rest time, locomotor task time 10.40.40.8-0.40.6-0.9
Distance moved, locomotor task time 10.80.91.50.7-1.20.8
Vertical activity count, locomotor time 10.40.41.0-0.2-1.00.5
Time >=10cm from walls, locomotor time 20.90.91.40.7-0.91.2
Bouts of movement, locomotor time 22.93.13.7-1.61.8-1.9
Total resting periods, locomotor time 24.14.35.0-1.82.2-2.2
Rest time, locomotor task time 23.64.15.3-1.42.2-2.3
Distance moved, locomotor task time 21.92.24.21.0-2.01.2
Vertical activity count, locomotor time 20.80.92.10.3-1.50.7
Light reinforcement 10.10.10.20.40.40.0
Light reinforcement 20.30.40.80.90.40.4
Bone: marrow area0.10.30.30.5-0.50.5
Bone: maximum diameter0.51.02.1-0.70.5-1.4
Bone: maximum force1.62.84.4-1.61.2-2.1
Bone: maximum moment1.22.13.1-1.60.9-1.8
Mean time between licks in bursts5.17.18.42.5-2.62.9
Mean num. licks in bursts1.21.42.20.9-1.51.1
Cd content in liver0.91.01.20.7-1.11.1
Co content in liver1.51.82.6-0.91.4-1.6
Cu content in liver0.20.30.4-0.60.6-0.3
Fe content in liver1.01.21.91.1-0.81.4
K content in liver0.10.10.20.50.20.0
Mg content in liver0.60.61.01.0-0.50.7
Mn content in liver0.80.91.31.2-1.00.5
Na content in liver3.43.66.6-2.61.5-1.4
Rb content in liver1.21.52.01.3-0.91.4
Se content in liver0.30.40.80.1-0.90.5
Sr content in liver2.42.23.11.5-1.11.8
Zn content in liver0.40.51.3-1.20.2-0.1
Bone: minimum diameter0.40.81.5-0.8-0.3-1.2
Time in familiar zone, hab. session 10.20.20.20.4-0.5-0.4
Time in novel zone, hab. session 11.71.72.6-1.31.6-0.9
Total zone transitions, hab. session 10.50.71.4-0.80.4-1.2
Total locomotion distance, hab. session 10.10.20.4-0.2-0.4-0.6
Locomotion velocity, hab. session 10.20.20.5-0.2-0.7-0.4
Time in familiar zone, hab. session 20.20.20.20.5-0.50.2
Time in novel zone, hab. session 20.10.10.1-0.30.3-0.3
Total zone transitions, hab. session 20.20.20.4-0.70.2-0.5
Total locomotion distance, hab. session 20.20.30.4-0.40.5-0.7
Locomotion velocity, hab. session 20.40.60.8-0.70.7-0.9
Novel to familiar place preference ratio0.20.20.30.5-0.60.0
Novelty place preference0.20.20.40.5-0.70.2
Time in novel zone, NPP test0.20.20.40.4-0.60.1
Total zone transitions, NPP test0.10.20.6-0.1-0.8-0.1
Total locomotion distance, NPP test2.02.74.61.4-2.11.3
Locomotion velocity, NPP test1.92.74.61.4-2.21.3
Intraocular pressure3.44.75.62.0-2.42.2
Delta distance traveled before/after self-admin0.50.50.9-0.61.0-0.5
Delta ambulatory time before/after self-admin0.30.30.4-0.50.6-0.5
Parametrial fat weight2.03.96.12.5-2.11.1
Pavlov. Cond. lever latency0.81.01.01.0-1.01.0
Pavlov. Cond. magazine entry latency0.60.81.4-0.81.2-0.4
Pavlov. Cond. change in total contacts3.13.33.5-1.91.9-1.7
Pavlov. Cond. index score2.43.03.7-1.81.9-1.4
Pavlov. Cond. latency score1.72.22.8-1.51.7-1.2
Pavlov. Cond. lever contacts1.21.51.9-1.31.4-0.9
Pavlov. Cond. magazine entry number1.21.52.01.4-1.31.0
Pavlov. Cond. intertrial magazine entries0.10.10.1-0.1-0.40.3
Pavlov. Cond. lever-magazine prob. diff.3.13.84.9-2.02.2-1.6
Pavlov. Cond. response bias2.22.73.4-1.81.8-1.3
Pavlov. Cond. lever latency0.30.41.31.1-0.20.0
Pavlov. Cond. magazine entry latency1.41.62.9-1.70.8-1.2
Pavlov. Cond. change in total contacts1.72.34.6-2.11.2-1.0
Pavlov. Cond. index score1.21.53.4-1.90.7-0.9
Pavlov. Cond. latency score1.01.23.0-1.70.5-0.7
Pavlov. Cond. lever contacts0.20.30.9-1.0-0.10.1
Pavlov. Cond. magazine entry number0.70.91.41.2-0.41.1
Pavlov. Cond. intertrial magazine entries9.111.914.13.8-3.43.2
Pavlov. Cond. lever-magazine prob. diff.1.31.73.5-1.90.7-1.0
Pavlov. Cond. response bias0.81.12.5-1.60.4-0.7
Time in closed arm before self-admin2.62.94.4-2.11.7-1.2
Time in closed arm after self-admin0.50.50.9-1.00.5-0.5
Time in open arm before self-admin1.51.61.91.3-1.41.0
Time in open arm after self-admin0.91.01.41.1-0.71.2
Bone: periosteal estimation0.10.20.5-0.30.2-0.7
Bone: periosteal perimeter0.00.10.1-0.0-0.3-0.3
Bone: post-yield work1.41.84.3-0.21.1-2.1
Progressive ratio test 1 active lever presses0.30.30.50.50.3-0.7
Progressive ratio test 1 breakpoint0.30.40.70.40.4-0.8
Progressive ratio test 1 inactive lever presses1.31.42.01.0-1.41.1
Progressive ratio test 2 active lever presses2.02.23.92.0-1.01.3
Progressive ratio test 2 breakpoint1.61.83.11.8-0.91.3
Progressive ratio test 2 inactive lever presses1.82.03.11.8-0.71.6
Incentive Sensitization - Responses3.33.45.31.8-1.22.3
Incentive Sensitization - Breakpoint3.73.75.91.8-1.42.4
Sum of active levers in priming session hrs 5-60.30.30.70.8-0.30.3
Progressive ratio0.40.51.3-1.10.4-0.1
Food seeking constrained by brief footshock0.30.41.00.41.0-0.3
Seeking ratio, punishment vs. effort0.30.30.50.70.6-0.4
Retroperitoneal fat weight0.10.30.91.0-0.20.2
Reaction time number correct0.60.91.11.0-0.81.1
Reaction time mean minus median0.20.30.9-1.00.1-0.2
Reaction time mean minus median AUC0.10.20.4-0.6-0.10.3
Reaction time num false alarms0.20.30.7-0.80.40.0
Reaction time num false alarms AUC0.30.40.7-0.90.6-0.1
Reaction time trials correct on left0.60.91.11.0-0.81.1
Reaction time trials on left0.81.11.41.1-0.91.2
Reaction time mean0.30.50.80.2-0.70.9
Reaction time mean AUC0.40.50.9-0.0-0.80.9
Median of all reaction times0.60.81.30.5-0.91.2
Reaction time omissions3.54.86.81.8-2.12.6
Reaction time false alarm rate0.81.21.6-1.31.1-0.8
Reaction time premature initiation rate0.81.11.7-0.71.3-1.1
Reaction time premature initiations0.20.20.5-0.00.7-0.4
Std. dev. reaction times0.10.10.2-0.1-0.40.4
Reaction time trials completed0.81.11.41.1-0.91.2
Reaction time trials AUC1.01.41.61.2-1.01.3
Run reversals in cocaine runway, females0.30.30.60.6-0.80.2
Run reversals in cocaine runway, males3.83.74.1-2.01.8-2.0
Latency to leave start box in cocaine runway1.51.61.71.2-1.31.2
Latency to leave start box in cocaine runway, F0.20.20.30.3-0.60.5
Latency to leave start box in cocaine runway, M2.72.63.71.5-1.31.9
Std. dev. time between licks in bursts2.53.03.81.5-1.91.8
Total sessions with >9 infusions1.81.92.21.3-1.41.5
Short access day 1 total inactive lever presses0.20.30.70.80.00.2
Short access day 10 total inactive lever presses0.30.40.50.7-0.40.7
Short access day 1 total infusions2.42.63.82.0-1.31.5
Short access day 10 total infusions0.30.30.90.1-0.3-1.0
Short access total infusions0.60.70.90.9-1.00.4
Short access day 1 locomotion0.60.71.00.3-1.01.0
Short access day 10 total locomotion0.20.20.6-0.8-0.0-0.3
Short access total locomotion0.20.20.3-0.3-0.50.3
One hour access (0.3 mA shock)0.30.30.80.9-0.4-0.1
Compulsive drug intake0.20.20.5-0.40.3-0.7
One hour access (shock baseline)0.80.91.81.3-0.70.7
Social response proportion2.22.33.31.8-1.11.6
Social responses3.34.35.12.3-2.11.8
Social time1.21.62.80.5-1.31.7
Soleus weight0.72.23.4-1.11.9-1.4
Bone: stiffness1.32.12.7-1.31.7-1.4
Tibialis anterior weight6.321.728.4-5.34.5-4.1
Time to tail flick, vehicle, before self-admin1.31.42.0-1.40.5-1.4
Time to tail flick, vehicle, after self-admin1.81.92.1-1.31.4-1.4
Time to tail flick, test, before self-admin0.10.10.1-0.40.10.3
Time to tail flick, test, after self-admin5.05.15.62.4-2.32.2
Delta time to tail flick, vehicle, before/after SA0.20.20.40.6-0.20.5
Delta time to tail flick, test, before/after SA4.54.05.92.4-1.91.6
Tibia length0.20.61.6-1.3-0.30.4
Ambulatory time before self-admin0.10.10.30.4-0.5-0.0
Ambulatory time after self-admin0.20.30.3-0.6-0.3-0.6
Bone: tissue strength1.00.91.30.7-1.11.0
Total heroin consumption0.40.50.8-0.90.4-0.7
Bone: trabecular number1.32.02.61.3-1.31.6
Bone: trabecular spacing3.03.94.7-1.91.8-2.2
Bone: trabecular thickness0.30.40.6-0.70.1-0.8
Bone: trabecular tissue density2.53.64.1-2.01.9-1.8
Water consumed over 24 hours0.60.71.2-1.10.8-0.6
Number of responses in last shaping day0.10.10.2-0.5-0.10.0