Hub : Genes

Ahnak

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Ahnak 0.09 0.05 2.1e-06 0.01 0.04 0.04 0.03 1.7e-02 5.2e-05 3.1e-05 2.2e-04
2 Adipose isoform ratio NM_001398671.1 0.03 0.02 3.6e-03 0.02 0.01 0.01 0.01 3.5e-03 1.9e-02 2.1e-02 1.4e-02
3 Adipose mRNA stability Ahnak 0.2 0.1 0.0e+00 0.11 0.12 0.1 0.12 1.2e-12 3.3e-13 1.6e-11 1.5e-13
4 Liver alternative polyA XM_017588769.3 0.04 0.03 4.6e-04 0.03 0.02 0.02 0.02 2.4e-04 6.3e-03 9.2e-04 8.7e-04
5 Liver alternative polyA XM_017588769.3 0.04 0.03 9.8e-04 0.03 0.01 0.02 0.03 2.3e-04 7.6e-03 1.6e-03 6.1e-04
6 NAcc isoform ratio NM_001398671.1 0.03 0.02 2.5e-05 0.04 0.04 0.03 0.03 4.6e-06 4.6e-06 5.3e-06 8.2e-06
7 Adipose alternative polyA XM_063278638.1 0.31 0.16 1.6e-05 0.03 0.01 0.01 0.02 3.9e-04 1.1e-02 1.4e-02 4.0e-03
8 Adipose isoform ratio XM_063278638.1 0.07 0.08 1.7e-04 0.03 0.02 0.04 0.02 2.4e-04 1.5e-03 5.1e-05 1.5e-03
9 Adipose alternative polyA XM_017588769.3 0.22 0.15 7.2e-04 0.01 0.01 0.03 0.01 5.0e-02 4.1e-02 6.3e-04 4.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.20.40.7-0.40.70.7-0.8-0.8-0.5-0.5-0.10.7
Area under the delay curve0.10.10.50.50.10.2-0.1-0.1-0.1-0.40.70.0
BMI with tail1.55.28.1-1.32.82.8-2.8-2.8-2.1-2.70.91.3
BMI without tail0.21.12.60.11.31.3-1.0-1.0-0.9-1.60.70.7
Body weight2.611.216.0-2.54.04.0-3.8-3.8-3.4-3.9-0.92.6
Weight adjusted by age0.30.91.4-1.21.11.1-1.1-1.1-1.0-0.9-0.0-0.0
Bone surface1.83.55.0-2.12.12.0-2.2-2.2-1.7-1.6-1.01.4
Bone volume0.71.42.2-1.51.31.3-1.4-1.4-0.9-0.8-0.50.9
Breakpoint value in progressive ratio session1.32.44.5-2.11.61.6-1.7-1.7-1.9-1.2-0.70.3
Number of licking bursts0.10.21.0-0.20.20.10.00.00.0-0.2-1.00.7
Context. condit. distance diff. score0.60.82.21.5-0.9-0.70.70.70.70.51.40.1
Locomotion velocity, session 10.20.31.21.1-0.30.10.10.10.0-0.40.20.9
Locomotion distance, session 10.50.62.40.50.50.7-0.6-0.6-0.6-1.0-0.11.6
Locomotion velocity, session 21.92.23.1-1.31.81.7-1.6-1.6-1.7-1.7-0.81.0
Locomotion distance, session 20.10.20.50.20.40.4-0.3-0.3-0.6-0.70.10.5
Locomotion velocity, session 30.20.30.60.40.50.6-0.3-0.3-0.2-0.80.70.6
Locomotion distance, session 30.10.10.40.20.30.4-0.2-0.2-0.2-0.6-0.10.7
Stereotopy head waving bouts, day 30.60.73.71.0-0.6-0.50.50.50.60.51.9-0.5
Stereotopy head waving duration, day 30.40.52.21.0-0.6-0.50.50.50.40.41.5-0.2
Locomotion velocity, session 70.10.10.50.2-0.1-0.20.20.20.10.20.7-0.1
Locomotion distance, session 70.30.41.81.1-0.4-0.20.40.40.3-0.11.4-0.3
Stereotopy head waving bouts, day 70.20.20.4-0.60.40.3-0.4-0.4-0.30.0-0.30.7
Stereotopy head waving duration, day 71.31.72.1-1.41.41.3-1.4-1.4-1.3-1.1-1.01.2
Locomotion velocity, session 80.10.21.11.0-0.4-0.20.30.3-0.0-0.20.30.1
Locomotion distance, session 80.50.82.01.3-0.8-0.80.80.80.80.61.40.1
Degree of sensitization distance0.30.31.80.7-0.3-0.30.20.20.40.21.4-0.4
Degree of sensitization stereotypy0.91.02.2-1.51.00.9-1.0-1.0-1.0-0.5-0.90.8
Conditioned locomotion0.40.50.7-0.60.80.8-0.9-0.9-0.8-0.8-0.30.3
Cocaine response after cond. corrected0.61.03.71.9-1.2-0.90.70.70.80.40.60.6
Cocaine response after cond. not corrected0.40.62.11.4-0.9-0.70.60.60.70.40.30.5
Cocaine response before conditioning0.50.62.4-1.50.90.7-0.7-0.7-0.6-0.3-0.8-0.4
Saline control response2.94.05.8-1.32.22.2-1.9-1.9-2.1-2.4-1.92.0
Bone: connectivity density1.32.13.3-1.11.71.7-1.8-1.8-1.4-1.5-0.30.7
Bone: cortical apparent density0.40.72.3-0.70.40.5-0.7-0.7-0.8-0.3-1.51.1
Bone: cortical area0.91.42.4-1.51.41.3-1.2-1.2-1.0-1.0-1.10.9
Bone: cortical porosity0.10.10.2-0.3-0.2-0.20.10.1-0.20.4-0.0-0.5
Bone: cortical porosity0.00.00.2-0.30.00.0-0.1-0.1-0.40.00.0-0.3
Bone: cortical thickness3.45.77.3-2.12.52.5-2.3-2.3-2.6-2.6-2.71.8
Bone: cortical thickness0.50.71.5-0.10.60.7-0.7-0.7-0.8-0.9-1.21.1
Bone: cortical tissue density0.50.92.6-0.80.60.6-0.8-0.8-1.0-0.5-1.61.1
Condit. Reinf. active minus inactive responses1.01.11.4-1.01.11.2-1.2-1.2-1.1-1.0-0.90.7
Condit. Reinf. active-inactive response ratio0.50.60.9-0.50.60.8-0.8-0.8-0.8-0.6-1.00.7
Condit. Reinf. active responses0.60.81.6-1.31.11.0-1.1-1.1-0.9-0.6-0.20.2
Condit. Reinf. inactive responses0.20.20.9-0.50.1-0.10.10.10.30.41.0-0.6
Incentive salience index mean1.01.31.8-1.01.31.3-1.3-1.3-1.1-1.2-0.81.1
Condit. Reinf. lever presses0.81.11.9-0.81.21.2-1.1-1.1-0.8-1.0-0.81.4
Condit. Reinf. active minus inactive responses0.10.20.5-0.6-0.2-0.40.30.30.30.7-0.3-0.3
Condit. Reinf. active-inactive response ratio0.60.92.0-0.4-0.7-0.90.70.70.91.41.0-1.4
Condit. Reinf. active responses0.20.31.2-0.70.40.4-0.3-0.3-0.3-0.2-1.10.8
Condit. Reinf. inactive responses0.60.92.80.10.60.7-0.6-0.6-0.6-1.1-1.61.7
Condit. Reinf. lever presses1.01.42.1-1.41.41.3-1.3-1.3-1.0-1.0-1.20.8
Condit. Reinf. lever reinforcers received0.40.61.5-1.00.70.6-0.6-0.6-0.6-0.4-1.20.8
Conditioned reinforcement - actives0.10.51.3-0.8-0.6-0.70.60.60.51.1-0.2-0.9
Conditioned reinforcement - inactives0.10.20.6-0.6-0.3-0.30.20.20.50.8-0.0-0.4
Conditioned locomotion2.02.94.01.7-1.9-1.81.71.71.92.01.1-1.3
Patch foraging indifference point 0 sec0.30.81.7-0.50.91.0-0.9-0.9-0.9-1.0-0.51.3
Patch foraging indifference point AUC0.92.16.0-2.51.41.3-1.5-1.5-1.5-0.6-1.50.3
Delay disc. indifference point, 0s delay0.60.72.21.5-0.7-0.60.70.70.70.21.2-0.1
Delay disc. indifference point, 16s delay0.10.10.1-0.30.30.3-0.3-0.3-0.1-0.20.3-0.1
Delay disc. indifference point, 2s delay0.30.40.60.7-0.5-0.60.50.50.70.50.8-0.7
Delay disc. indifference point, 24s delay0.10.10.40.40.30.4-0.3-0.3-0.3-0.6-0.00.6
Delay disc. indifference point, 4s delay0.30.30.90.70.40.6-0.4-0.4-0.5-1.00.50.3
Delay disc. indifference point, 8s delay0.30.51.51.2-0.7-0.50.70.70.50.21.0-0.3
Indifference point function ln k1.75.115.53.9-2.5-2.12.22.22.41.31.40.5
Indifference point function log k1.75.115.53.9-2.5-2.12.22.22.41.31.40.5
Patch foraging total patch changes 0 sec0.31.02.5-0.30.91.0-0.9-0.9-1.0-1.2-0.81.6
Patch foraging total patch changes 12 sec5.47.39.7-3.12.92.9-3.0-3.0-3.1-2.5-1.91.6
Patch foraging total patch changes 18 sec0.51.12.0-1.30.90.8-1.0-1.0-1.0-0.6-1.40.8
Patch foraging total patch changes 24 sec2.38.010.0-2.53.03.0-3.2-3.2-2.9-2.8-2.12.6
Patch foraging total patch changes 6 sec1.11.92.7-0.91.41.4-1.5-1.5-1.4-1.4-1.01.7
Patch foraging time to switch 0 sec0.10.40.9-0.70.60.5-0.5-0.5-0.4-0.20.9-0.7
Patch foraging water rate 0 sec0.20.71.11.0-0.8-0.70.70.70.80.4-1.01.1
Patch foraging water rate 12 sec0.62.46.62.6-1.7-1.51.71.71.70.70.30.3
Patch foraging water rate 18 sec0.41.04.82.2-0.7-0.50.80.80.9-0.30.41.0
Patch foraging water rate 24 sec1.11.63.71.9-1.5-1.41.41.41.30.90.60.0
Patch foraging water rate 6 sec1.21.85.32.3-1.4-1.21.51.51.40.6-0.20.7
Seeking ratio, delayed vs. immediate footshock0.00.00.10.10.20.2-0.2-0.2-0.1-0.3-0.40.1
Distance traveled before self-admin1.22.64.1-2.01.81.7-1.8-1.8-1.5-1.2-1.31.2
Distance traveled after self-admin0.40.81.3-1.20.70.8-0.9-0.9-0.9-0.5-1.10.8
Extensor digitorum longus weight5.722.829.2-4.05.45.4-5.2-5.2-5.0-5.2-3.43.7
Bone: elastic displacement0.20.30.70.8-0.6-0.60.60.60.40.20.2-0.5
Bone: elastic work0.81.12.4-0.21.11.2-1.1-1.1-1.2-1.5-0.50.7
Bone: endosteal estimation1.02.55.61.4-1.4-1.41.31.32.01.62.4-0.9
Bone: endosteal perimeter1.43.36.01.0-1.7-1.91.71.72.42.32.2-1.1
Epididymis fat weight0.42.23.90.7-1.1-1.41.31.32.01.52.0-1.7
Delta time in closed arm before/after self-admin0.90.92.60.70.81.0-0.8-0.8-1.1-1.60.70.6
Delta time in open arm before/after self-admin1.61.95.0-2.21.41.3-1.5-1.5-1.4-0.7-1.20.7
Diff in mean of infusions in LGA sessions1.42.63.8-1.41.61.7-1.7-1.7-2.0-1.6-1.21.5
Delay discount exponential model param0.10.10.4-0.5-0.1-0.20.10.10.10.4-0.6-0.0
Extinction: sum of active levers before priming2.63.94.8-1.92.12.1-2.2-2.2-2.0-1.8-1.61.8
Active lever presses in extinction session 62.72.75.6-2.41.71.7-1.8-1.8-1.8-1.1-1.30.8
Bone: final force1.42.23.1-1.51.81.7-1.6-1.6-1.4-1.5-1.01.3
Bone: final moment1.52.43.4-1.51.81.8-1.7-1.7-1.4-1.6-1.01.3
Food consumed during 24 hour testing period0.00.10.5-0.40.0-0.20.20.20.30.2-0.70.1
Glucose2.53.96.22.1-1.9-1.91.91.92.31.72.5-1.4
Heart weight0.50.83.11.8-0.4-0.30.50.50.9-0.21.7-0.0
Delay discount hyperbolic model param0.10.10.4-0.5-0.0-0.10.00.0-0.00.3-0.70.1
Intermittent access intake day 1-15 change0.31.73.4-0.0-1.3-1.61.41.41.51.8-0.2-1.2
Intermittent access intake escalation0.42.14.2-0.1-1.5-1.81.61.61.62.0-0.3-1.2
Intermittent access intake escalation 20.40.61.5-0.6-0.7-0.90.80.80.81.2-0.5-0.6
Intermitt. access day 1 inactive lever presses0.11.42.20.3-1.3-1.41.41.41.11.50.5-1.3
Intermitt. access day 15 inactive lever presses0.10.72.0-1.40.90.8-0.8-0.8-0.5-0.4-1.00.3
Intermitt. access escalation Index0.20.71.61.3-1.0-0.90.90.90.90.70.4-0.1
Intermittent access day 1 total infusions0.30.91.61.3-0.8-0.70.80.81.30.81.1-0.8
Intermittent access day 15 total infusions1.74.16.71.2-2.1-2.32.22.22.62.60.7-1.7
Intermittent access terminal intake (last 3 days)0.81.42.70.4-1.1-1.31.11.11.71.60.5-1.1
Intermittent access total infusions1.31.52.71.0-1.2-1.21.21.21.61.50.9-1.1
Intermittent access day 1 locomotion0.20.30.80.9-0.4-0.30.30.30.70.40.9-0.5
Intermittent access day 15 total locomotion0.10.41.2-0.0-0.6-0.60.40.40.81.10.5-0.8
Intermittent access total locomotion0.50.61.40.3-0.6-0.60.50.51.21.20.8-0.8
Intermittent access standard deviation0.21.01.80.3-1.1-1.21.11.11.11.40.2-1.0
Left kidney weight0.10.93.60.4-0.4-0.60.60.61.00.71.9-1.1
Right kidney weight0.10.41.50.1-0.2-0.40.40.40.70.51.2-1.0
Cocaine induced anxiety0.00.10.7-0.80.10.1-0.1-0.1-0.30.10.0-0.6
Post-drug Anxiety0.30.30.8-0.90.60.5-0.6-0.6-0.6-0.4-0.30.0
Baseline Anxiety0.30.51.10.20.60.7-0.6-0.6-0.6-0.9-0.41.1
Tail length0.41.93.7-0.81.31.3-1.0-1.0-1.3-1.6-1.91.8
Length with tail1.67.18.8-2.12.82.7-2.5-2.5-2.6-2.8-3.03.0
Length without tail1.89.611.4-2.43.33.3-3.2-3.2-3.2-3.4-2.83.0
Times rat made contact with spout0.40.51.80.00.40.4-0.3-0.3-0.5-0.8-1.41.1
Lifetime Intake1.01.32.11.3-1.1-1.11.11.11.51.20.7-0.8
Liver weight, left0.81.41.81.1-1.3-1.31.31.31.31.10.6-0.9
Liver weight, right1.22.15.02.2-1.5-1.51.61.61.80.90.9-0.0
Locomotor activity0.61.03.41.9-1.1-0.91.11.10.80.20.60.1
Locomotor testing distance0.61.45.32.3-1.2-1.01.21.21.00.20.80.1
Locomotor testing rearing0.41.33.81.9-1.2-1.11.31.31.20.40.9-0.2
Locomotion in novel chamber2.02.73.41.1-1.7-1.61.61.61.81.81.7-1.7
Locomotion in novel chamber post-restriction0.92.74.30.9-1.8-1.91.71.71.72.11.1-1.5
Fecal boli incidents, locomotor time 10.10.31.1-0.7-0.4-0.60.40.40.51.0-0.1-0.7
Change in fecal boli incidents, locomotor task1.21.23.71.9-1.2-1.01.21.21.10.50.7-0.2
Time >=10cm from walls, locomotor time 11.72.14.30.4-1.4-1.61.51.51.72.10.8-1.3
Bouts of movement, locomotor time 10.30.41.9-1.40.30.3-0.2-0.2-0.90.1-0.3-0.7
Total resting periods, locomotor time 10.30.41.9-1.40.30.3-0.3-0.3-0.80.1-0.3-0.7
Rest time, locomotor task time 10.81.32.10.7-1.3-1.51.21.21.41.4-0.0-0.8
Distance moved, locomotor task time 10.10.30.4-0.20.60.6-0.6-0.6-0.5-0.60.00.5
Vertical activity count, locomotor time 10.10.60.80.9-0.8-0.70.80.80.80.60.7-0.3
Time >=10cm from walls, locomotor time 20.10.20.9-0.9-0.1-0.20.10.10.20.8-0.4-0.6
Bouts of movement, locomotor time 20.41.41.7-1.31.31.2-1.3-1.3-1.3-1.1-1.01.0
Total resting periods, locomotor time 20.20.70.9-0.90.90.8-0.9-0.9-0.9-0.7-0.70.7
Rest time, locomotor task time 22.03.34.21.7-2.0-2.02.02.02.01.91.0-1.4
Distance moved, locomotor task time 20.50.71.0-1.00.80.9-0.9-0.9-1.0-0.8-0.60.5
Vertical activity count, locomotor time 20.00.10.20.3-0.10.00.10.1-0.2-0.3-0.20.5
Light reinforcement 10.10.31.6-0.1-0.1-0.10.10.10.10.1-1.30.9
Light reinforcement 20.20.31.0-0.9-0.1-0.50.30.30.61.00.1-0.6
Bone: marrow area1.22.95.91.5-1.5-1.61.51.52.21.72.4-1.0
Bone: maximum diameter0.10.20.9-1.00.50.4-0.5-0.5-0.10.0-0.10.2
Bone: maximum force1.73.35.2-2.02.32.1-2.2-2.2-1.6-1.8-0.41.0
Bone: maximum moment1.83.55.4-2.02.32.2-2.2-2.2-1.7-1.9-0.41.1
Mean time between licks in bursts0.10.72.50.70.70.9-0.6-0.6-0.6-1.6-0.20.8
Mean num. licks in bursts0.00.10.20.4-0.3-0.20.10.1-0.0-0.00.3-0.2
Cd content in liver0.80.92.10.4-1.1-1.20.90.91.01.40.5-0.3
Co content in liver0.60.71.81.4-1.1-0.91.01.00.60.5-0.50.2
Cu content in liver0.00.00.10.2-0.1-0.10.10.1-0.10.10.2-0.3
Fe content in liver0.00.10.10.4-0.3-0.20.10.10.20.30.30.1
K content in liver0.50.51.0-0.40.90.8-0.5-0.5-0.5-0.9-0.71.0
Mg content in liver0.20.21.40.60.10.2-0.0-0.00.1-0.5-0.21.2
Mn content in liver3.13.54.9-2.22.22.0-2.0-2.0-1.9-1.7-1.51.2
Na content in liver0.60.61.3-0.70.80.7-0.7-0.7-0.5-0.7-1.11.1
Rb content in liver2.22.64.32.1-1.7-1.72.02.01.81.21.0-0.4
Se content in liver0.10.20.8-0.90.40.2-0.3-0.3-0.10.10.2-0.4
Sr content in liver4.23.64.5-2.02.02.0-2.0-2.0-2.1-1.8-1.61.2
Zn content in liver2.12.43.3-1.31.71.7-1.8-1.8-1.8-1.6-0.91.2
Bone: minimum diameter0.61.13.00.6-0.7-0.90.90.91.51.11.7-0.7
Time in familiar zone, hab. session 10.10.10.70.00.20.4-0.4-0.4-0.1-0.3-0.10.8
Time in novel zone, hab. session 11.01.11.61.3-1.2-1.21.31.31.10.80.3-0.7
Total zone transitions, hab. session 10.40.62.1-0.40.50.4-0.4-0.4-0.6-0.5-1.31.5
Total locomotion distance, hab. session 10.10.10.30.2-0.4-0.40.30.30.40.60.30.3
Locomotion velocity, hab. session 10.00.10.2-0.30.20.2-0.2-0.2-0.30.0-0.10.4
Time in familiar zone, hab. session 20.20.30.80.6-0.4-0.20.30.30.4-0.1-0.90.8
Time in novel zone, hab. session 20.30.30.6-0.40.60.6-0.6-0.6-0.6-0.50.7-0.3
Total zone transitions, hab. session 21.51.95.3-0.31.31.4-1.2-1.2-1.2-1.6-1.22.3
Total locomotion distance, hab. session 20.20.21.40.30.30.3-0.2-0.2-0.2-0.5-0.11.2
Locomotion velocity, hab. session 20.10.10.90.30.10.1-0.0-0.00.0-0.20.10.9
Novel to familiar place preference ratio1.31.73.1-1.81.61.5-1.4-1.4-1.5-1.1-0.0-0.2
Novelty place preference0.91.12.3-1.51.31.1-1.1-1.1-1.1-0.80.3-0.5
Time in novel zone, NPP test0.91.12.0-1.41.31.2-1.1-1.1-1.2-0.90.3-0.5
Total zone transitions, NPP test0.91.43.2-0.41.11.2-1.1-1.1-1.3-1.3-1.01.8
Total locomotion distance, NPP test0.10.10.30.50.00.10.00.0-0.2-0.30.40.4
Locomotion velocity, NPP test0.00.10.20.4-0.1-0.00.10.1-0.2-0.10.20.4
Intraocular pressure0.10.10.2-0.3-0.3-0.30.30.30.20.5-0.3-0.2
Delta distance traveled before/after self-admin0.40.41.31.1-0.8-0.60.60.60.40.3-0.10.5
Delta ambulatory time before/after self-admin0.40.61.71.3-1.0-0.80.90.90.70.50.10.1
Parametrial fat weight1.63.87.41.1-1.7-1.91.71.72.32.22.7-1.7
Pavlov. Cond. lever latency0.81.01.30.9-1.1-1.11.11.10.90.90.5-1.1
Pavlov. Cond. magazine entry latency0.81.02.1-1.41.21.1-1.3-1.3-0.8-0.6-0.30.4
Pavlov. Cond. change in total contacts0.40.41.6-1.30.60.5-0.7-0.7-0.40.2-0.10.1
Pavlov. Cond. index score0.60.81.6-1.31.00.9-1.1-1.1-0.8-0.5-0.60.5
Pavlov. Cond. latency score0.50.60.9-0.90.90.9-1.0-1.0-0.7-0.6-0.50.7
Pavlov. Cond. lever contacts0.40.50.8-0.60.80.7-0.8-0.8-0.5-0.6-0.30.9
Pavlov. Cond. magazine entry number0.81.02.51.6-1.0-1.01.21.21.00.40.7-0.2
Pavlov. Cond. intertrial magazine entries0.40.42.4-0.90.20.1-0.1-0.1-0.40.30.6-1.5
Pavlov. Cond. lever-magazine prob. diff.0.70.92.0-1.41.01.0-1.1-1.1-0.8-0.4-0.60.5
Pavlov. Cond. response bias0.81.02.2-1.51.11.0-1.2-1.2-0.9-0.6-0.70.6
Pavlov. Cond. lever latency0.60.81.21.0-1.0-1.01.11.10.70.70.8-0.6
Pavlov. Cond. magazine entry latency4.15.87.5-2.72.72.6-2.7-2.7-2.6-2.2-1.81.2
Pavlov. Cond. change in total contacts1.02.44.5-2.11.61.5-1.8-1.8-1.3-0.9-1.60.9
Pavlov. Cond. index score2.23.55.5-2.32.12.0-2.2-2.2-1.8-1.5-1.40.7
Pavlov. Cond. latency score1.93.05.1-2.32.01.9-2.1-2.1-1.7-1.3-1.10.6
Pavlov. Cond. lever contacts0.50.71.1-1.10.90.9-1.0-1.0-0.7-0.6-0.80.4
Pavlov. Cond. magazine entry number6.88.811.83.4-3.3-3.23.43.43.22.62.1-1.4
Pavlov. Cond. intertrial magazine entries0.81.82.91.0-1.6-1.61.51.51.51.70.5-0.6
Pavlov. Cond. lever-magazine prob. diff.2.64.16.1-2.52.32.1-2.4-2.4-2.0-1.6-1.50.8
Pavlov. Cond. response bias2.12.93.9-1.81.91.8-2.0-2.0-1.6-1.5-1.41.0
Time in closed arm before self-admin0.10.10.4-0.60.0-0.20.10.10.40.5-0.5-0.0
Time in closed arm after self-admin0.70.81.61.3-0.8-0.91.01.01.00.50.7-0.7
Time in open arm before self-admin1.11.46.32.5-1.2-0.81.11.10.80.10.80.1
Time in open arm after self-admin0.30.40.8-0.30.40.7-0.7-0.7-0.9-0.6-0.40.6
Bone: periosteal estimation0.10.10.6-0.30.1-0.0-0.0-0.00.60.40.70.0
Bone: periosteal perimeter0.00.10.3-0.60.2-0.0-0.1-0.10.40.40.00.2
Bone: post-yield work0.30.52.8-0.1-0.2-0.3-0.0-0.00.90.81.7-0.3
Progressive ratio test 1 active lever presses0.30.60.90.6-0.9-0.80.80.80.81.00.6-0.8
Progressive ratio test 1 breakpoint0.30.61.00.6-0.8-0.80.80.80.81.00.6-0.8
Progressive ratio test 1 inactive lever presses0.20.40.6-0.70.80.8-0.7-0.7-0.7-0.7-0.40.4
Progressive ratio test 2 active lever presses0.81.12.30.3-1.1-1.11.01.01.31.50.6-1.0
Progressive ratio test 2 breakpoint0.81.02.20.3-1.0-1.10.90.91.21.50.5-1.0
Progressive ratio test 2 inactive lever presses0.30.91.60.1-0.8-0.90.80.81.11.30.8-1.2
Incentive Sensitization - Responses0.20.51.1-1.10.80.7-0.9-0.9-0.4-0.4-0.10.2
Incentive Sensitization - Breakpoint0.10.30.9-1.00.60.6-0.8-0.8-0.3-0.2-0.10.1
Sum of active levers in priming session hrs 5-61.71.66.8-2.61.00.8-1.1-1.1-1.1-0.0-1.50.1
Progressive ratio0.00.10.5-0.10.10.0-0.0-0.00.40.2-0.50.7
Food seeking constrained by brief footshock0.10.20.60.5-0.2-0.20.30.30.20.0-0.40.8
Seeking ratio, punishment vs. effort0.10.21.01.0-0.3-0.10.20.2-0.1-0.40.5-0.0
Retroperitoneal fat weight3.616.120.03.9-4.0-4.14.24.24.53.74.4-3.1
Reaction time number correct0.31.11.8-0.61.11.1-0.9-0.9-0.8-1.3-1.31.3
Reaction time mean minus median0.21.04.6-2.20.80.6-0.9-0.9-0.90.2-0.2-0.8
Reaction time mean minus median AUC0.10.42.2-1.50.40.3-0.5-0.5-0.60.1-0.5-0.5
Reaction time num false alarms0.30.52.51.6-0.8-0.50.50.50.3-0.00.50.0
Reaction time num false alarms AUC0.10.21.31.1-0.30.1-0.1-0.1-0.3-0.60.20.3
Reaction time trials correct on left0.31.11.8-0.61.11.1-0.9-0.9-0.8-1.3-1.31.3
Reaction time trials on left0.31.21.9-0.61.11.1-0.9-0.9-0.8-1.3-1.41.3
Reaction time mean0.10.20.8-0.8-0.3-0.4-0.1-0.10.00.90.1-0.7
Reaction time mean AUC0.10.20.9-0.7-0.3-0.50.10.10.20.9-0.1-0.7
Median of all reaction times0.10.10.5-0.4-0.3-0.3-0.1-0.10.10.70.1-0.3
Reaction time omissions0.30.51.3-1.10.60.5-0.8-0.8-0.9-0.3-0.60.2
Reaction time false alarm rate0.40.62.11.4-0.9-0.60.50.50.30.31.0-0.5
Reaction time premature initiation rate3.75.810.0-1.02.62.7-2.5-2.5-2.3-3.2-1.82.4
Reaction time premature initiations2.78.313.6-1.43.13.2-2.9-2.9-2.8-3.7-2.63.0
Std. dev. reaction times0.10.41.2-1.1-0.3-0.3-0.1-0.1-0.10.90.1-1.1
Reaction time trials completed0.31.21.9-0.61.11.1-0.9-0.9-0.8-1.3-1.41.3
Reaction time trials AUC0.31.01.7-0.41.01.0-0.8-0.8-0.7-1.3-1.31.3
Run reversals in cocaine runway, females0.50.51.21.00.50.7-0.5-0.5-0.3-1.00.21.1
Run reversals in cocaine runway, males0.30.40.60.6-0.7-0.70.80.80.60.6-0.1-0.4
Latency to leave start box in cocaine runway0.40.51.30.8-0.6-0.70.60.60.90.61.1-0.5
Latency to leave start box in cocaine runway, F0.00.00.1-0.10.20.2-0.2-0.2-0.0-0.30.2-0.1
Latency to leave start box in cocaine runway, M2.22.12.81.4-1.5-1.51.51.51.71.41.6-0.8
Std. dev. time between licks in bursts0.10.21.41.2-0.2-0.10.30.30.2-0.60.30.3
Total sessions with >9 infusions0.81.01.41.2-1.1-1.11.01.01.11.10.5-0.7
Short access day 1 total inactive lever presses0.10.20.70.8-0.4-0.20.10.10.40.30.8-0.4
Short access day 10 total inactive lever presses0.10.60.80.8-0.9-0.80.80.80.70.70.5-0.5
Short access day 1 total infusions0.81.62.71.6-1.4-1.31.31.31.51.20.5-0.8
Short access day 10 total infusions0.30.51.01.0-0.6-0.60.60.61.00.60.4-0.3
Short access total infusions0.71.02.81.7-1.0-0.91.01.01.20.80.6-0.5
Short access day 1 locomotion0.20.30.60.6-0.6-0.60.60.60.80.70.0-0.3
Short access day 10 total locomotion0.00.00.10.10.00.0-0.1-0.10.30.2-0.10.1
Short access total locomotion0.10.20.40.5-0.5-0.40.40.40.70.70.3-0.3
One hour access (0.3 mA shock)1.11.32.20.9-1.2-1.21.11.11.51.40.5-1.0
Compulsive drug intake0.71.02.1-0.31.01.1-1.1-1.1-1.2-1.5-0.40.9
One hour access (shock baseline)1.64.16.61.1-2.1-2.32.22.22.42.60.9-1.8
Social response proportion0.10.10.4-0.10.50.3-0.1-0.1-0.2-0.6-0.3-0.1
Social responses0.30.31.5-0.30.40.3-0.2-0.2-0.4-0.6-1.20.7
Social time0.10.10.60.10.0-0.00.10.1-0.2-0.3-0.80.7
Soleus weight2.67.710.02.8-3.1-3.13.23.23.12.81.7-1.3
Bone: stiffness0.61.02.7-1.61.21.0-1.0-1.0-0.7-0.6-0.80.6
Tibialis anterior weight8.128.034.5-5.35.95.8-5.8-5.8-5.9-5.2-4.13.5
Time to tail flick, vehicle, before self-admin0.10.10.3-0.20.30.2-0.4-0.4-0.1-0.10.6-0.3
Time to tail flick, vehicle, after self-admin0.20.30.90.30.50.6-0.5-0.5-0.4-0.7-0.40.9
Time to tail flick, test, before self-admin0.30.30.60.80.30.6-0.5-0.5-0.1-0.70.60.6
Time to tail flick, test, after self-admin0.10.10.4-0.70.30.1-0.2-0.2-0.10.1-0.0-0.4
Delta time to tail flick, vehicle, before/after SA0.30.30.80.10.50.6-0.3-0.3-0.5-0.7-0.60.9
Delta time to tail flick, test, before/after SA0.30.42.2-1.50.2-0.1-0.1-0.1-0.40.4-0.6-0.7
Tibia length1.43.89.5-3.12.21.8-2.0-2.0-1.9-1.1-1.81.1
Ambulatory time before self-admin0.72.24.8-2.21.61.5-1.6-1.6-1.4-0.9-1.20.9
Ambulatory time after self-admin0.20.30.8-0.90.40.4-0.5-0.5-0.4-0.1-0.90.7
Bone: tissue strength0.20.20.40.5-0.3-0.30.60.60.60.0-0.50.5
Total heroin consumption5.46.49.2-2.92.72.6-2.7-2.7-3.0-2.4-1.71.6
Bone: trabecular number0.71.21.9-0.91.31.4-1.4-1.4-1.0-1.1-0.20.8
Bone: trabecular spacing0.30.50.91.0-0.8-0.70.90.90.60.3-0.3-0.2
Bone: trabecular thickness0.10.20.6-0.1-0.4-0.40.30.30.50.80.3-0.3
Bone: trabecular tissue density3.56.29.22.3-3.0-2.92.92.92.62.80.8-1.1
Water consumed over 24 hours0.71.33.1-0.71.11.0-0.9-0.9-0.9-1.3-1.81.4
Number of responses in last shaping day0.10.10.30.30.30.4-0.3-0.3-0.5-0.60.4-0.0