Hub : Genes

Znrd2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC isoform ratio XR_005492543.1 0.19 0.16 6.5e-03 -0.01 0.06 -0.01 -0.01 4.7e-01 1.6e-02 8.9e-01 6.9e-01
2 Brain gene expression Znrd2 0.31 0.1 0.0e+00 0.33 0.3 0.31 0.33 1.5e-31 9.9e-29 1.6e-29 2.9e-31
3 OFC gene expression Znrd2 0.26 0.12 3.3e-05 0.16 0.18 0.16 0.16 1.2e-04 3.9e-05 1.2e-04 1.1e-04
4 pVTA gene expression Znrd2 0.21 0.1 4.6e-08 0.16 0.14 0.13 0.14 2.8e-07 1.4e-06 2.1e-06 1.3e-06
5 BLA gene expression Znrd2 0.31 0.12 0.0e+00 0.33 0.32 0.33 0.33 1.9e-18 7.4e-18 3.5e-18 1.9e-18
6 PL gene expression Znrd2 0.28 0.1 0.0e+00 0.41 0.39 0.39 0.4 2.7e-48 1.1e-45 1.3e-45 4.9e-47
7 Brain intron excision ratio chr1_203018382_203018914 0.33 0.1 0.0e+00 0.43 0.4 0.42 0.42 6.1e-43 3.1e-39 3.1e-42 1.1e-42
8 Brain isoform ratio XR_005492543.1 0.19 0.08 0.0e+00 0.23 0.22 0.2 0.22 9.1e-21 1.7e-20 1.2e-18 1.4e-20
9 Brain isoform ratio NM_001109537.2 0.2 0.08 0.0e+00 0.23 0.23 0.21 0.23 3.1e-21 8.2e-21 4.1e-19 5.7e-21
10 Brain intron excision ratio chr1_203018382_203018677 0.22 0.09 0.0e+00 0.28 0.25 0.27 0.27 6.4e-26 9.6e-23 2.8e-25 1.5e-25
11 pVTA intron excision ratio chr1_203018382_203018914 0.32 0.12 6.4e-13 0.22 0.24 0.21 0.22 4.6e-10 8.5e-11 2.1e-09 5.5e-10
12 IL isoform ratio XR_005492543.1 0.13 0.08 9.3e-03 0.07 0.02 0.01 0.04 8.7e-03 8.8e-02 2.1e-01 3.1e-02
13 OFC intron excision ratio chr1_203018382_203018914 0.22 0.12 6.4e-04 0.14 0.13 0.1 0.1 3.5e-04 5.5e-04 2.6e-03 1.9e-03
14 IL gene expression Znrd2 0.67 0.15 1.9e-09 0.26 0.26 0.27 0.26 5.2e-07 5.4e-07 2.9e-07 5.4e-07
15 BLA isoform ratio XR_005492543.1 0.29 0.12 8.1e-13 0.18 0.22 0.22 0.22 3.8e-10 4.5e-12 1.0e-11 2.8e-12
16 LHb gene expression Znrd2 0.22 0.11 1.7e-04 0.09 0.18 0.1 0.14 4.3e-03 3.8e-05 2.0e-03 3.2e-04
17 BLA isoform ratio NM_001109537.2 0.28 0.12 2.7e-12 0.17 0.21 0.21 0.22 1.4e-09 1.8e-11 2.6e-11 6.6e-12
18 Adipose intron excision ratio chr1_203018382_203018914 0.06 0.04 1.3e-04 0.01 0.02 0.01 0.01 1.6e-02 2.4e-03 7.4e-03 1.4e-02
19 RMTg isoform ratio NM_001109537.2 0.25 0.12 7.1e-05 0.1 0.12 0.13 0.11 1.2e-03 4.6e-04 2.3e-04 8.6e-04
20 RMTg isoform ratio XR_005492543.1 0.26 0.13 9.0e-05 0.1 0.12 0.12 0.1 9.7e-04 3.8e-04 3.6e-04 1.1e-03
21 pVTA isoform ratio XR_005492543.1 0.41 0.15 1.1e-16 0.29 0.32 0.32 0.32 7.2e-13 2.1e-14 1.6e-14 2.0e-14
22 pVTA isoform ratio NM_001109537.2 0.42 0.15 1.7e-16 0.29 0.32 0.32 0.32 6.8e-13 1.8e-14 1.0e-14 1.2e-14
23 NAcc gene expression Znrd2 0.2 0.09 0.0e+00 0.23 0.23 0.25 0.25 7.8e-26 1.3e-26 1.5e-28 2.3e-28
24 Brain mRNA stability Znrd2 0.06 0.04 1.8e-05 0.05 0.05 0.07 0.06 2.1e-05 1.2e-05 2.8e-07 6.4e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Bone: apparent density0.71.23.4-1.10.9-0.80.70.60.6-0.50.8-0.80.81.40.8-0.80.6-1.7-0.01.81.6-1.71.51.6-1.50.0-1.2
Area under the delay curve0.30.32.9-0.2-0.30.5-0.3-0.4-0.40.2-0.40.4-0.50.3-0.30.3-0.7-0.30.50.20.30.1-0.10.5-0.4-1.7-0.5
BMI with tail3.912.728.9-3.53.1-3.23.03.03.0-2.83.1-3.13.04.52.8-2.82.8-4.8-1.65.05.1-5.45.23.6-3.72.0-1.8
BMI without tail1.73.58.0-2.01.5-1.41.61.61.6-1.71.5-1.51.52.61.3-1.31.1-2.5-0.92.62.8-2.82.62.1-2.10.4-1.6
Body weight4.016.922.4-4.14.3-4.44.34.34.3-4.24.3-4.34.34.74.1-4.14.5-4.5-3.64.44.7-4.64.53.9-3.90.70.7
Weight adjusted by age2.22.43.8-1.51.6-1.91.61.51.5-1.51.8-1.81.81.41.8-1.81.9-1.4-1.71.41.3-1.21.21.2-1.20.61.8
Bone surface4.78.312.1-2.82.9-3.32.82.82.8-2.72.8-2.82.83.12.8-2.83.0-3.5-2.03.53.2-3.43.23.3-3.30.60.5
Bone volume2.03.46.7-1.81.7-2.11.51.51.5-1.41.6-1.61.62.01.6-1.61.7-2.5-0.82.62.2-2.62.52.2-2.11.0-0.4
Breakpoint value in progressive ratio session3.43.85.3-2.12.1-2.22.12.02.0-1.92.3-2.32.31.82.1-2.12.2-2.0-1.92.01.7-1.71.71.5-1.51.21.1
Number of licking bursts0.30.40.5-0.70.7-0.70.70.60.6-0.60.7-0.70.60.60.7-0.70.6-0.7-0.50.70.6-0.50.40.4-0.4-0.00.3
Context. condit. distance diff. score1.92.23.61.5-1.51.8-1.6-1.6-1.61.4-1.81.8-1.8-1.4-1.71.7-1.91.41.6-1.4-1.21.0-0.9-1.31.30.5-1.1
Locomotion velocity, session 10.00.00.30.20.10.10.0-0.0-0.0-0.20.0-0.00.00.00.1-0.10.20.4-0.4-0.5-0.00.2-0.20.1-0.1-0.50.3
Locomotion distance, session 10.70.92.2-0.90.7-0.50.60.60.6-0.70.8-0.80.81.40.9-0.90.6-1.3-0.41.31.5-1.21.11.2-1.2-1.0-0.3
Locomotion velocity, session 23.13.65.1-2.01.8-1.91.81.81.8-2.22.0-2.02.02.22.0-2.01.9-2.1-1.62.12.3-2.01.91.8-1.80.50.7
Locomotion distance, session 20.81.12.5-1.20.8-0.70.90.80.8-1.01.1-1.11.11.51.1-1.10.9-1.4-0.71.41.6-1.10.91.1-1.0-0.60.2
Locomotion velocity, session 30.20.21.30.4-0.40.3-0.5-0.5-0.50.5-0.30.3-0.30.2-0.20.2-0.0-0.20.60.30.5-0.91.00.1-0.10.4-1.1
Locomotion distance, session 30.00.00.10.2-0.20.2-0.3-0.2-0.20.1-0.10.1-0.1-0.1-0.10.10.00.20.2-0.2-0.10.00.0-0.20.20.0-0.2
Stereotopy head waving bouts, day 30.50.61.21.0-0.80.8-0.8-0.9-0.90.9-1.01.0-1.0-0.1-1.11.1-0.70.31.0-0.30.2-0.40.60.2-0.2-0.3-0.6
Stereotopy head waving duration, day 30.70.81.71.0-1.01.0-1.0-1.0-1.01.0-1.21.2-1.2-0.5-1.31.3-1.10.51.1-0.5-0.30.1-0.1-0.0-0.0-0.6-0.7
Locomotion velocity, session 70.50.62.70.2-0.80.5-0.8-0.8-0.80.7-0.50.5-0.50.1-0.40.4-0.7-0.41.20.60.5-1.01.1-0.40.41.7-1.2
Locomotion distance, session 70.10.11.10.0-0.20.4-0.2-0.2-0.20.4-0.10.1-0.10.2-0.00.0-0.3-0.20.40.30.5-0.60.7-0.10.21.0-0.5
Stereotopy head waving bouts, day 70.10.20.50.1-0.30.0-0.4-0.5-0.50.5-0.50.5-0.5-0.1-0.50.5-0.5-0.20.70.30.0-0.20.2-0.10.10.4-0.6
Stereotopy head waving duration, day 71.01.22.8-1.41.1-1.31.01.01.0-1.00.9-0.90.91.40.9-0.90.7-1.7-0.61.71.4-1.21.01.2-1.2-0.2-0.4
Locomotion velocity, session 80.81.01.8-0.51.1-0.81.11.11.1-1.21.1-1.11.10.91.2-1.21.2-0.4-1.40.30.8-0.50.51.0-1.0-0.61.3
Locomotion distance, session 80.20.31.20.4-0.50.4-0.5-0.5-0.50.3-0.50.5-0.50.0-0.50.5-0.4-0.00.70.10.3-0.70.8-0.10.11.1-0.5
Degree of sensitization distance0.20.21.00.0-0.00.1-0.00.00.00.2-0.00.0-0.00.40.0-0.0-0.0-0.40.30.40.6-0.91.00.4-0.40.8-0.4
Degree of sensitization stereotypy0.50.61.5-1.00.8-1.10.70.60.6-0.60.7-0.70.70.80.7-0.70.6-1.1-0.31.20.8-0.90.70.5-0.50.8-0.4
Conditioned locomotion1.51.82.4-1.21.5-1.51.51.51.5-1.41.5-1.51.41.41.5-1.51.5-1.0-1.60.91.3-1.11.11.0-1.0-0.71.0
Cocaine response after cond. corrected1.41.62.71.6-1.51.6-1.5-1.4-1.41.4-1.41.4-1.4-1.2-1.41.4-1.31.51.2-1.5-1.00.9-0.8-0.90.9-0.5-0.7
Cocaine response after cond. not corrected1.11.22.31.5-1.31.4-1.3-1.2-1.21.2-1.21.2-1.2-1.0-1.21.2-1.11.31.1-1.3-0.80.6-0.5-0.60.6-0.5-0.4
Cocaine response before conditioning0.70.91.3-1.01.0-1.11.00.90.9-1.11.0-1.01.00.80.9-0.91.0-1.0-0.81.00.8-0.80.90.8-0.80.90.8
Saline control response4.05.26.9-2.22.6-2.22.62.62.6-2.42.6-2.62.52.42.5-2.52.4-2.1-2.41.92.3-1.71.52.3-2.3-1.22.0
Bone: connectivity density2.64.17.4-2.12.0-1.91.91.81.8-1.82.0-2.02.02.42.0-2.01.7-2.7-1.22.72.5-2.42.12.6-2.5-0.1-0.3
Bone: cortical apparent density0.20.31.0-1.00.6-0.20.70.70.7-0.70.5-0.50.50.40.6-0.60.0-0.3-0.60.30.20.4-0.7-0.00.1-0.60.1
Bone: cortical area0.81.22.7-0.81.0-1.51.00.90.9-1.01.3-1.31.30.81.3-1.31.6-0.9-1.01.00.9-1.41.50.4-0.41.40.6
Bone: cortical porosity0.20.20.6-0.50.4-0.20.30.30.3-0.40.3-0.30.30.60.2-0.2-0.1-0.80.00.80.7-0.50.30.6-0.6-0.5-0.7
Bone: cortical porosity0.60.71.2-1.00.9-0.70.90.80.8-1.00.8-0.80.81.10.6-0.60.5-1.1-0.51.11.1-0.80.51.1-1.0-0.8-0.3
Bone: cortical thickness2.23.76.6-1.92.2-2.02.12.22.2-2.22.5-2.52.51.62.5-2.52.5-1.2-2.61.11.3-1.00.90.6-0.60.41.6
Bone: cortical thickness0.40.51.5-0.50.7-0.40.70.70.7-0.71.0-1.01.00.41.0-1.00.90.0-1.2-0.10.20.3-0.30.1-0.10.11.1
Bone: cortical tissue density0.30.31.1-1.10.7-0.30.80.80.8-0.80.6-0.60.60.50.6-0.60.1-0.4-0.70.30.30.4-0.80.00.0-0.70.2
Condit. Reinf. active minus inactive responses0.20.20.4-0.70.3-0.30.50.50.5-0.40.5-0.50.50.60.5-0.50.3-0.6-0.30.60.6-0.30.20.2-0.10.20.2
Condit. Reinf. active-inactive response ratio0.10.10.4-0.50.10.10.10.10.1-0.10.1-0.10.10.10.2-0.2-0.1-0.2-0.10.20.00.4-0.7-0.10.2-0.40.1
Condit. Reinf. active responses0.20.21.0-0.40.2-0.30.30.30.3-0.10.4-0.40.40.40.4-0.40.3-0.60.10.70.6-0.70.70.1-0.01.0-0.0
Condit. Reinf. inactive responses0.20.32.50.2-0.1-0.2-0.1-0.1-0.10.30.1-0.10.10.1-0.00.00.2-0.40.50.60.5-1.11.30.1-0.11.6-0.4
Incentive salience index mean0.40.51.2-0.80.5-0.60.60.60.6-0.60.7-0.70.71.00.7-0.70.5-1.0-0.31.11.1-1.00.90.5-0.50.5-0.2
Condit. Reinf. lever presses0.60.82.4-0.60.6-1.00.70.70.7-0.70.7-0.70.70.90.7-0.70.9-0.9-0.51.01.1-1.41.60.7-0.81.20.0
Condit. Reinf. active minus inactive responses0.10.10.30.1-0.40.0-0.4-0.4-0.40.5-0.30.3-0.3-0.3-0.30.3-0.2-0.10.60.2-0.2-0.10.3-0.30.30.1-0.5
Condit. Reinf. active-inactive response ratio0.50.51.20.8-0.90.1-0.9-0.9-0.91.0-0.80.8-0.8-0.7-0.70.7-0.20.11.10.0-0.4-0.50.8-0.70.61.0-0.8
Condit. Reinf. active responses0.10.21.3-0.60.2-0.20.20.10.10.00.2-0.20.20.40.2-0.2-0.0-0.70.10.70.4-0.20.10.4-0.4-1.1-0.4
Condit. Reinf. inactive responses0.40.63.3-1.10.60.00.60.60.6-0.60.6-0.60.60.90.6-0.6-0.1-0.9-0.40.80.80.1-0.41.1-1.0-1.8-0.1
Condit. Reinf. lever presses2.43.35.0-1.91.8-2.21.81.81.8-1.82.0-2.02.01.72.1-2.12.1-2.0-1.52.01.7-1.81.81.5-1.51.00.8
Condit. Reinf. lever reinforcers received0.30.41.0-1.00.6-0.60.60.50.5-0.40.6-0.60.60.70.6-0.60.3-1.0-0.31.00.6-0.40.20.6-0.6-0.9-0.1
Conditioned reinforcement - actives0.30.31.90.6-0.6-0.0-0.6-0.5-0.50.5-0.30.3-0.3-0.7-0.30.30.00.50.3-0.5-0.70.00.2-0.00.01.40.6
Conditioned reinforcement - inactives5.76.59.42.6-2.62.4-2.8-2.8-2.82.9-2.72.7-2.7-3.1-2.62.6-2.62.62.7-2.4-2.92.5-2.2-2.22.21.4-0.6
Conditioned locomotion7.89.413.73.5-3.43.0-3.4-3.3-3.33.3-3.23.2-3.2-3.7-3.23.2-3.03.52.9-3.4-3.62.6-2.2-2.72.70.8-1.3
Patch foraging indifference point 0 sec0.00.10.60.10.00.3-0.1-0.2-0.20.2-0.20.2-0.2-0.2-0.20.2-0.40.10.3-0.0-0.10.1-0.1-0.00.00.80.1
Patch foraging indifference point AUC3.54.05.6-2.22.2-2.42.32.32.3-2.32.3-2.32.41.92.2-2.22.2-2.0-2.11.91.7-1.41.31.7-1.70.60.7
Delay disc. indifference point, 0s delay0.70.84.70.4-1.01.1-1.0-0.7-0.70.5-1.01.0-1.1-0.0-1.01.0-1.20.20.9-0.40.10.5-0.40.6-0.5-2.2-0.4
Delay disc. indifference point, 16s delay0.70.71.70.4-0.91.0-0.9-1.1-1.11.1-0.80.8-1.0-0.7-0.90.9-1.20.21.3-0.1-0.60.5-0.4-0.91.00.2-1.2
Delay disc. indifference point, 2s delay0.10.10.30.3-0.40.2-0.4-0.4-0.40.3-0.40.4-0.3-0.1-0.40.4-0.10.00.40.0-0.0-0.40.6-0.10.10.5-0.5
Delay disc. indifference point, 24s delay0.30.32.70.2-0.30.7-0.3-0.5-0.50.3-0.30.3-0.4-0.2-0.30.3-0.60.50.1-0.6-0.30.9-0.8-0.00.1-1.60.7
Delay disc. indifference point, 4s delay0.40.43.10.2-0.50.9-0.5-0.5-0.50.4-0.60.6-0.50.1-0.50.5-0.80.10.5-0.20.10.7-0.70.6-0.5-1.80.4
Delay disc. indifference point, 8s delay0.40.47.0-0.1-0.30.6-0.3-0.4-0.40.1-0.40.4-0.50.2-0.30.3-0.70.10.3-0.30.20.3-0.30.6-0.5-2.6-0.4
Indifference point function ln k8.211.416.03.8-3.74.0-3.8-3.8-3.83.9-3.63.6-3.6-3.3-3.83.8-3.63.53.3-3.4-3.02.7-2.4-3.23.20.2-1.3
Indifference point function log k8.211.416.03.8-3.74.0-3.8-3.8-3.83.9-3.63.6-3.6-3.3-3.83.8-3.63.53.3-3.4-3.02.7-2.4-3.23.20.2-1.3
Patch foraging total patch changes 0 sec0.00.10.30.20.10.3-0.0-0.1-0.10.1-0.10.1-0.1-0.2-0.20.2-0.30.30.0-0.3-0.30.3-0.3-0.10.10.50.4
Patch foraging total patch changes 12 sec5.06.48.6-2.92.8-2.62.92.82.8-2.82.9-2.92.92.62.9-2.92.5-2.7-2.42.72.5-1.91.62.4-2.30.80.7
Patch foraging total patch changes 18 sec0.70.91.5-1.01.0-1.01.01.01.0-1.10.8-0.80.91.00.9-0.90.8-1.2-0.61.21.0-1.00.91.0-1.00.50.1
Patch foraging total patch changes 24 sec2.42.94.6-1.61.9-1.82.02.02.0-2.11.9-1.91.91.52.0-2.01.9-1.3-2.01.21.3-0.90.81.5-1.5-0.42.1
Patch foraging total patch changes 6 sec1.11.62.4-1.21.5-1.11.41.31.3-1.31.4-1.41.41.31.6-1.61.2-1.3-1.11.31.3-1.10.91.3-1.20.60.5
Patch foraging time to switch 0 sec2.43.77.6-2.21.8-2.01.81.71.7-1.61.6-1.61.52.31.7-1.71.4-2.7-0.92.82.6-2.62.42.0-2.00.9-0.8
Patch foraging water rate 0 sec4.57.312.53.2-2.72.7-2.6-2.6-2.62.6-2.62.6-2.6-3.3-2.72.7-2.33.51.8-3.5-3.43.0-2.7-3.02.90.10.4
Patch foraging water rate 12 sec9.814.923.64.5-4.04.3-3.9-3.9-3.93.8-3.83.8-3.8-4.3-3.93.9-3.64.82.7-4.9-4.44.3-4.1-3.73.6-1.9-0.1
Patch foraging water rate 18 sec3.44.67.42.7-2.32.5-2.3-2.3-2.32.2-2.22.2-2.2-2.3-2.02.0-1.92.71.7-2.7-2.22.2-2.0-1.81.8-0.90.1
Patch foraging water rate 24 sec4.86.711.33.2-2.72.7-2.7-2.7-2.72.4-2.92.9-2.8-2.8-2.62.6-2.23.31.8-3.4-2.92.5-2.2-2.42.4-0.7-0.1
Patch foraging water rate 6 sec4.66.812.13.3-2.62.9-2.6-2.6-2.62.5-2.52.5-2.5-2.9-2.42.4-2.23.41.7-3.5-2.92.9-2.7-2.62.6-1.70.2
Seeking ratio, delayed vs. immediate footshock0.10.10.7-0.40.10.4-0.0-0.2-0.20.2-0.20.2-0.20.2-0.10.1-0.6-0.30.40.40.20.1-0.3-0.20.2-0.2-0.8
Distance traveled before self-admin0.60.61.3-1.00.8-1.20.80.90.9-0.90.7-0.70.70.80.6-0.60.8-0.9-0.70.90.8-0.70.70.8-0.80.30.2
Distance traveled after self-admin0.20.20.5-0.60.6-0.70.60.50.5-0.50.5-0.50.50.30.4-0.40.4-0.5-0.40.60.3-0.20.10.2-0.2-0.1-0.0
Extensor digitorum longus weight7.629.735.5-5.75.8-5.95.95.95.9-5.85.9-5.95.95.96.0-6.06.0-5.5-5.45.45.8-5.45.24.7-4.80.91.9
Bone: elastic displacement1.71.94.21.7-1.21.5-1.2-1.2-1.21.3-0.90.9-0.9-1.6-1.01.0-0.92.00.4-2.0-1.71.9-1.8-1.51.5-1.60.6
Bone: elastic work0.60.72.6-0.40.8-0.50.90.90.9-0.81.2-1.21.20.61.1-1.11.1-0.1-1.3-0.00.4-0.0-0.00.3-0.3-1.61.1
Bone: endosteal estimation0.61.33.41.4-1.30.7-1.3-1.5-1.51.4-1.41.4-1.4-0.5-1.41.4-0.90.11.80.00.1-1.01.30.0-0.10.5-1.5
Bone: endosteal perimeter0.71.54.21.5-1.50.6-1.5-1.6-1.61.6-1.51.5-1.5-0.7-1.51.5-0.90.12.10.1-0.2-1.01.30.0-0.10.9-1.5
Epididymis fat weight2.25.17.92.5-2.72.2-2.7-2.7-2.72.5-2.72.7-2.7-2.2-2.82.8-2.41.92.8-1.7-1.81.2-0.8-1.51.40.9-1.9
Delta time in closed arm before/after self-admin0.20.23.20.30.10.40.10.00.0-0.00.1-0.10.10.20.2-0.20.20.3-0.4-0.40.20.4-0.20.6-0.6-1.80.6
Delta time in open arm before/after self-admin0.10.10.8-0.40.3-0.60.20.30.3-0.20.2-0.20.2-0.10.2-0.20.2-0.2-0.20.3-0.2-0.10.2-0.10.10.9-0.2
Diff in mean of infusions in LGA sessions0.40.52.6-0.60.7-0.70.70.50.5-0.60.8-0.80.80.30.8-0.80.9-0.4-0.80.40.20.00.20.8-0.80.31.6
Delay discount exponential model param0.20.22.70.20.3-0.50.30.40.4-0.10.3-0.30.3-0.30.3-0.30.60.3-0.4-0.2-0.3-0.20.1-0.50.41.60.3
Extinction: sum of active levers before priming5.05.07.7-2.82.4-2.42.42.32.3-2.22.5-2.52.52.52.3-2.32.0-2.7-1.92.82.5-2.22.01.8-1.80.90.6
Active lever presses in extinction session 62.52.55.0-1.21.5-2.11.61.61.6-1.71.7-1.71.71.11.7-1.72.2-1.1-1.81.00.9-1.11.31.3-1.41.32.1
Bone: final force3.15.06.8-2.12.4-2.62.42.42.4-2.42.2-2.22.22.42.3-2.32.5-2.3-2.12.22.4-2.52.52.0-2.10.41.0
Bone: final moment2.74.46.0-2.02.3-2.52.22.22.2-2.22.1-2.12.12.22.2-2.22.4-2.1-1.92.12.2-2.42.41.9-2.00.30.9
Food consumed during 24 hour testing period0.10.10.9-0.10.2-0.40.20.20.2-0.30.3-0.30.2-0.30.2-0.20.30.2-0.4-0.3-0.50.5-0.5-0.10.10.01.0
Glucose1.52.24.81.5-1.91.6-1.8-1.8-1.81.8-1.91.9-1.9-1.1-1.91.9-1.80.82.2-0.6-0.70.1-0.0-0.40.40.0-1.8
Heart weight3.14.46.52.3-2.42.6-2.5-2.4-2.42.3-2.42.4-2.4-2.0-2.42.4-2.42.02.4-1.9-1.81.6-1.5-1.51.5-0.2-1.2
Delay discount hyperbolic model param0.20.22.20.20.2-0.40.20.30.3-0.10.2-0.20.3-0.30.2-0.20.50.3-0.3-0.2-0.3-0.0-0.0-0.50.41.50.2
Intermittent access intake day 1-15 change0.80.81.91.0-0.80.4-0.8-0.8-0.80.8-0.80.8-0.8-1.3-0.60.6-0.51.30.5-1.3-1.40.6-0.3-1.01.00.90.2
Intermittent access intake escalation0.60.61.30.9-0.80.5-0.8-0.8-0.80.8-0.80.8-0.8-1.2-0.60.6-0.51.00.7-1.0-1.20.6-0.3-1.01.00.80.2
Intermittent access intake escalation 20.30.31.00.5-0.40.1-0.3-0.3-0.30.4-0.40.4-0.4-0.9-0.40.4-0.20.80.1-0.9-1.00.7-0.6-0.70.70.40.7
Intermitt. access day 1 inactive lever presses2.22.43.31.5-1.61.6-1.7-1.8-1.81.8-1.71.7-1.7-1.7-1.71.7-1.81.41.8-1.3-1.61.0-0.7-1.11.10.8-1.7
Intermitt. access day 15 inactive lever presses2.12.33.71.6-1.71.3-1.8-1.8-1.81.9-1.61.6-1.6-1.9-1.31.3-1.31.51.8-1.3-1.81.2-0.8-1.51.51.2-0.5
Intermitt. access escalation Index3.22.85.61.5-1.92.2-2.0-1.8-1.81.8-1.81.8-1.8-1.3-1.81.8-2.11.02.1-0.9-1.01.0-1.1-1.71.7-0.7-2.4
Intermittent access day 1 total infusions4.04.610.62.3-2.82.3-2.7-2.6-2.62.6-2.52.5-2.5-1.7-2.42.4-2.41.13.3-0.9-1.20.4-0.2-0.70.81.4-2.8
Intermittent access day 15 total infusions6.67.411.73.2-3.42.6-3.3-3.2-3.23.3-3.03.0-3.0-3.0-2.82.8-2.72.43.4-2.2-2.61.3-0.9-1.91.92.1-1.9
Intermittent access terminal intake (last 3 days)4.44.88.62.6-2.81.9-2.7-2.6-2.62.7-2.52.5-2.5-2.4-2.32.3-2.01.72.9-1.5-1.90.6-0.3-1.41.42.2-1.8
Intermittent access total infusions3.43.88.32.2-2.61.9-2.6-2.4-2.42.4-2.12.1-2.1-1.9-1.91.9-1.91.22.9-0.9-1.40.4-0.2-1.01.02.0-2.1
Intermittent access day 1 locomotion2.83.09.01.8-2.32.0-2.2-2.1-2.12.1-1.91.9-1.9-1.2-1.81.8-1.90.82.6-0.6-0.7-0.20.4-0.30.31.0-3.0
Intermittent access day 15 total locomotion4.04.37.32.3-2.52.0-2.5-2.5-2.52.5-2.32.3-2.3-2.3-2.12.1-2.11.82.7-1.6-2.00.6-0.2-1.21.31.6-2.1
Intermittent access total locomotion4.75.411.82.5-2.92.2-2.9-2.8-2.82.8-2.72.7-2.7-2.1-2.52.5-2.51.43.4-1.1-1.50.20.1-1.01.12.2-3.0
Intermittent access standard deviation1.11.22.21.3-1.40.9-1.3-1.2-1.21.2-1.21.2-1.2-1.5-1.01.0-0.91.41.0-1.3-1.50.7-0.5-0.70.7-0.1-0.6
Left kidney weight0.61.72.81.3-1.40.9-1.3-1.3-1.31.3-1.51.5-1.5-1.4-1.51.5-1.31.21.4-1.0-1.20.6-0.3-1.71.61.5-0.7
Right kidney weight0.20.54.70.7-0.5-0.2-0.5-0.5-0.50.3-0.60.6-0.6-0.9-0.50.5-0.00.70.4-0.6-0.8-0.00.5-1.10.92.20.1
Cocaine induced anxiety0.10.11.30.2-0.1-0.30.0-0.1-0.1-0.00.0-0.00.0-0.1-0.10.10.30.1-0.1-0.1-0.1-0.10.20.1-0.11.10.7
Post-drug Anxiety1.41.53.1-0.81.3-1.71.31.21.2-1.21.3-1.31.30.81.1-1.11.7-0.7-1.40.60.7-1.31.50.9-1.01.81.4
Baseline Anxiety2.42.53.8-1.41.9-1.71.81.81.8-1.61.7-1.71.71.41.8-1.82.0-1.1-1.91.01.3-1.51.61.4-1.40.31.3
Tail length0.51.44.3-0.81.2-1.11.41.41.4-1.51.3-1.31.30.61.3-1.31.4-0.0-2.1-0.30.20.3-0.40.6-0.6-1.31.8
Length with tail1.86.611.7-2.33.0-2.93.03.03.0-3.03.0-3.03.02.23.0-3.03.4-1.7-3.41.51.8-1.31.31.9-2.0-0.72.6
Length without tail2.55.410.1-2.02.7-2.62.52.52.5-2.32.8-2.82.72.12.7-2.73.2-1.9-2.51.92.0-1.81.91.8-1.90.01.9
Times rat made contact with spout0.40.52.1-1.00.7-0.20.70.80.8-0.70.8-0.80.70.80.7-0.70.2-0.8-0.60.70.7-0.1-0.20.7-0.6-1.5-0.2
Lifetime Intake2.83.27.52.0-2.41.9-2.4-2.2-2.22.3-2.02.0-2.0-1.6-1.81.8-1.81.02.7-0.8-1.10.3-0.1-0.70.81.7-2.0
Liver weight, left0.10.11.40.4-0.20.1-0.2-0.3-0.30.3-0.30.3-0.3-0.2-0.40.4-0.10.20.3-0.2-0.1-0.30.3-0.20.21.2-0.6
Liver weight, right0.10.10.70.8-0.30.3-0.3-0.3-0.30.4-0.20.2-0.3-0.1-0.30.30.10.50.1-0.5-0.0-0.30.50.1-0.20.30.1
Locomotor activity2.13.36.42.3-1.72.1-1.9-1.9-1.91.7-1.71.7-1.7-2.1-1.61.6-1.42.51.1-2.5-2.12.1-1.9-1.61.5-1.60.2
Locomotor testing distance3.15.19.22.8-2.22.7-2.3-2.4-2.42.1-2.02.0-2.0-2.4-2.02.0-1.82.91.3-3.0-2.52.6-2.5-1.81.8-2.70.1
Locomotor testing rearing2.84.312.32.3-2.12.6-2.1-2.2-2.22.0-1.91.9-1.9-2.0-1.91.9-2.02.31.5-2.4-2.12.4-2.4-0.80.9-3.5-0.6
Locomotion in novel chamber4.25.27.12.7-2.61.9-2.6-2.7-2.72.5-2.62.6-2.6-2.6-2.42.4-2.22.22.5-2.1-2.41.5-1.0-2.01.91.8-0.3
Locomotion in novel chamber post-restriction2.73.34.52.0-2.11.8-2.0-2.1-2.12.0-1.91.9-1.9-2.0-1.91.9-1.81.82.0-1.6-1.81.0-0.7-1.81.81.3-1.1
Fecal boli incidents, locomotor time 10.20.23.0-0.30.2-0.90.00.10.1-0.20.2-0.20.30.00.0-0.00.6-0.3-0.00.40.1-0.50.7-0.0-0.01.70.3
Change in fecal boli incidents, locomotor task0.20.20.80.20.00.40.2-0.0-0.00.1-0.00.0-0.00.40.0-0.0-0.2-0.1-0.00.00.50.0-0.00.9-0.9-0.90.7
Time >=10cm from walls, locomotor time 10.60.62.00.7-0.70.1-0.8-0.8-0.80.8-0.90.9-1.0-0.2-0.90.9-0.6-0.31.40.40.2-0.50.90.6-0.71.4-0.2
Bouts of movement, locomotor time 11.11.23.6-1.91.4-1.11.31.31.3-1.41.2-1.21.11.01.3-1.30.7-1.0-1.30.80.7-0.30.10.5-0.3-1.7-0.1
Total resting periods, locomotor time 10.80.92.9-1.71.2-1.01.11.11.1-1.11.0-1.01.00.91.1-1.10.6-0.9-1.00.90.6-0.30.20.4-0.3-1.2-0.2
Rest time, locomotor task time 11.21.42.31.5-1.31.0-1.3-1.4-1.41.2-1.11.1-1.1-1.4-1.31.3-0.91.50.9-1.4-1.41.2-0.9-0.90.80.0-0.0
Distance moved, locomotor task time 10.20.20.8-0.50.3-0.20.30.20.2-0.20.3-0.30.30.70.5-0.50.2-0.70.10.70.8-0.90.70.5-0.40.8-0.4
Vertical activity count, locomotor time 11.21.31.91.2-1.21.3-1.3-1.3-1.31.4-1.21.2-1.1-1.2-1.11.1-1.21.11.2-1.0-1.11.0-0.9-1.11.10.7-0.0
Time >=10cm from walls, locomotor time 20.10.10.4-0.50.1-0.50.10.20.2-0.3-0.10.1-0.10.30.0-0.0-0.1-0.40.00.30.20.1-0.20.5-0.5-0.10.7
Bouts of movement, locomotor time 20.50.61.6-1.30.8-0.60.90.80.8-0.70.9-0.90.90.70.8-0.80.4-0.8-0.60.80.50.2-0.30.4-0.4-1.10.4
Total resting periods, locomotor time 20.30.31.1-1.10.6-0.30.70.60.6-0.50.7-0.70.70.50.6-0.60.1-0.7-0.30.70.40.3-0.40.4-0.3-1.00.2
Rest time, locomotor task time 22.22.53.81.8-1.91.6-1.9-2.0-2.01.6-1.91.9-1.9-1.5-1.91.9-1.61.51.8-1.5-1.41.5-1.1-0.70.7-0.5-0.9
Distance moved, locomotor task time 20.91.11.9-1.21.2-1.11.21.11.1-1.21.2-1.21.21.01.4-1.41.1-0.9-1.30.80.8-0.80.50.5-0.50.40.9
Vertical activity count, locomotor time 20.30.42.40.60.00.30.0-0.1-0.10.20.0-0.0-0.0-0.60.1-0.10.00.9-0.5-1.0-0.80.8-0.8-0.80.8-0.21.5
Light reinforcement 10.20.41.70.5-0.50.7-0.5-0.4-0.40.3-0.40.4-0.3-0.7-0.60.6-0.60.70.3-0.7-0.81.2-1.3-0.20.3-0.30.4
Light reinforcement 20.91.26.01.1-1.30.4-1.2-1.2-1.21.0-1.01.0-0.9-1.3-1.21.2-0.60.91.0-0.8-1.20.5-0.2-1.11.02.5-0.1
Bone: marrow area0.61.43.61.4-1.40.8-1.4-1.5-1.51.4-1.51.5-1.5-0.5-1.51.5-0.90.21.90.00.1-1.01.30.0-0.10.3-1.6
Bone: maximum diameter0.30.52.4-0.10.5-1.30.50.40.4-0.50.5-0.50.50.40.5-0.51.3-0.5-0.40.50.5-1.21.50.4-0.61.20.8
Bone: maximum force4.17.011.9-2.62.6-3.02.62.52.5-2.52.5-2.52.53.02.6-2.62.8-3.2-1.83.23.1-3.43.42.5-2.60.80.4
Bone: maximum moment3.56.010.4-2.42.4-2.82.32.32.3-2.32.3-2.32.32.72.4-2.42.6-2.9-1.73.02.9-3.23.22.4-2.40.70.3
Mean time between licks in bursts0.50.85.6-0.41.0-0.21.00.90.9-0.80.9-0.90.70.80.8-0.80.6-0.1-1.1-0.10.6-0.1-0.10.8-0.8-2.40.9
Mean num. licks in bursts0.30.30.80.3-0.60.9-0.6-0.5-0.50.5-0.50.5-0.5-0.4-0.50.5-0.90.40.4-0.5-0.40.8-0.9-0.20.3-0.9-0.4
Cd content in liver1.41.52.91.4-1.20.9-1.2-1.2-1.21.1-1.31.3-1.3-1.7-1.21.2-1.01.41.0-1.4-1.71.3-1.1-1.31.30.50.0
Co content in liver2.53.08.11.4-1.32.0-1.3-1.3-1.31.1-1.41.4-1.4-1.8-1.41.4-1.82.10.7-2.2-2.02.7-2.8-1.71.7-2.5-0.2
Cu content in liver0.30.41.1-1.10.5-0.50.50.50.5-0.50.7-0.70.70.70.7-0.70.3-0.9-0.31.00.7-0.50.20.4-0.30.0-0.5
Fe content in liver0.20.20.9-0.00.3-0.60.30.30.3-0.30.5-0.50.50.20.4-0.40.8-0.2-0.50.20.3-0.50.70.3-0.40.81.0
K content in liver2.32.34.6-1.41.3-1.41.31.31.3-1.31.4-1.41.41.81.5-1.51.4-1.9-0.81.92.0-2.12.01.6-1.60.6-0.4
Mg content in liver0.60.62.3-0.90.3-0.20.20.20.2-0.20.3-0.30.31.10.4-0.4-0.0-1.40.41.51.4-1.31.01.0-0.8-0.2-1.4
Mn content in liver2.73.04.7-1.81.8-2.21.81.81.8-1.82.0-2.02.01.71.9-1.92.0-1.8-1.61.81.6-1.61.61.4-1.40.21.1
Na content in liver1.11.22.4-0.81.2-1.51.21.21.2-1.21.2-1.21.20.91.1-1.11.5-0.8-1.30.70.8-1.01.10.8-0.91.10.7
Rb content in liver1.21.53.10.9-1.51.6-1.5-1.5-1.51.6-1.31.3-1.3-0.9-1.31.3-1.80.61.7-0.5-0.70.6-0.7-0.60.7-0.6-1.5
Se content in liver0.10.10.4-0.1-0.1-0.5-0.1-0.1-0.10.10.1-0.10.10.00.2-0.20.3-0.60.30.70.1-0.30.40.2-0.2-0.10.1
Sr content in liver2.42.24.3-1.61.9-1.81.91.91.9-1.91.7-1.71.71.21.7-1.71.8-0.9-2.10.80.8-0.50.40.9-0.9-0.01.1
Zn content in liver1.21.32.5-1.61.3-1.11.21.21.2-1.21.2-1.21.21.31.2-1.21.0-1.4-0.91.41.3-1.10.90.9-0.80.10.1
Bone: minimum diameter0.61.25.20.7-1.20.7-1.2-1.3-1.31.3-1.11.1-1.1-0.2-1.11.1-1.1-0.31.80.60.3-1.01.0-0.10.20.7-2.3
Time in familiar zone, hab. session 10.20.21.10.4-0.40.4-0.5-0.5-0.50.7-0.30.3-0.3-0.2-0.40.4-0.40.00.70.1-0.0-0.40.4-0.20.21.1-0.8
Time in novel zone, hab. session 10.50.52.10.7-0.40.8-0.4-0.4-0.40.2-0.60.6-0.6-0.6-0.50.5-0.51.1-0.0-1.2-0.81.1-1.0-0.20.2-1.40.5
Total zone transitions, hab. session 10.71.01.9-1.41.1-1.01.01.01.0-0.91.2-1.21.21.11.2-1.20.8-1.2-0.81.21.1-0.80.60.7-0.60.40.0
Total locomotion distance, hab. session 10.20.30.70.4-0.60.4-0.7-0.7-0.70.7-0.70.7-0.7-0.2-0.70.7-0.60.10.8-0.00.0-0.40.6-0.20.20.8-0.9
Locomotion velocity, hab. session 10.10.10.3-0.1-0.1-0.0-0.2-0.2-0.20.2-0.20.2-0.20.2-0.20.2-0.2-0.30.40.40.4-0.50.50.0-0.00.4-0.6
Time in familiar zone, hab. session 20.20.21.30.7-0.10.5-0.0-0.0-0.00.2-0.00.0-0.0-0.2-0.00.00.20.7-0.3-0.8-0.30.3-0.3-0.10.0-1.10.5
Time in novel zone, hab. session 20.20.20.7-0.80.2-0.30.20.20.2-0.30.2-0.20.20.50.2-0.2-0.2-0.80.10.80.5-0.30.10.4-0.30.0-0.5
Total zone transitions, hab. session 21.92.45.4-1.81.3-1.11.31.21.2-1.41.3-1.31.32.21.3-1.30.8-2.3-0.72.32.3-1.81.42.1-2.0-1.2-0.5
Total locomotion distance, hab. session 20.30.31.1-0.3-0.10.2-0.1-0.1-0.10.0-0.20.2-0.20.8-0.20.2-0.3-0.80.50.91.1-1.01.00.7-0.7-0.5-1.0
Locomotion velocity, hab. session 20.30.41.2-0.1-0.40.2-0.3-0.3-0.30.2-0.40.4-0.40.6-0.40.4-0.4-0.70.80.80.9-1.01.10.6-0.60.0-1.1
Novel to familiar place preference ratio1.31.32.5-1.51.1-1.51.21.21.2-1.01.1-1.11.11.11.0-1.01.0-1.5-0.71.61.1-1.11.00.9-0.91.40.2
Novelty place preference0.60.61.8-1.20.7-1.10.70.70.7-0.60.7-0.70.70.70.6-0.60.5-1.1-0.41.20.7-0.70.60.7-0.71.3-0.1
Time in novel zone, NPP test0.40.41.1-1.00.6-0.90.60.60.6-0.50.6-0.60.60.60.5-0.50.4-0.9-0.31.00.6-0.60.40.6-0.61.0-0.1
Total zone transitions, NPP test2.43.55.1-2.21.9-1.91.91.81.8-2.01.9-1.91.92.31.8-1.81.5-2.3-1.52.22.3-1.91.72.1-2.10.10.6
Total locomotion distance, NPP test0.20.20.9-0.50.2-0.20.20.20.2-0.30.1-0.10.10.70.1-0.10.0-0.70.10.80.9-0.90.90.5-0.50.4-0.5
Locomotion velocity, NPP test0.20.30.8-0.70.3-0.40.30.30.3-0.30.3-0.30.30.80.2-0.20.1-0.8-0.00.90.9-0.90.90.5-0.50.6-0.5
Intraocular pressure0.91.22.91.3-1.10.6-1.1-1.1-1.11.0-1.11.1-1.2-1.6-1.21.2-0.91.40.8-1.4-1.71.3-0.9-0.80.80.60.6
Delta distance traveled before/after self-admin0.10.10.60.3-0.10.4-0.0-0.3-0.30.2-0.10.1-0.1-0.3-0.00.0-0.20.3-0.0-0.3-0.30.3-0.3-0.40.4-0.8-0.1
Delta ambulatory time before/after self-admin0.10.11.10.20.00.40.1-0.2-0.20.10.0-0.00.0-0.20.0-0.0-0.10.3-0.2-0.3-0.20.4-0.4-0.20.2-1.10.3
Parametrial fat weight1.73.47.31.7-2.11.8-2.1-2.1-2.12.2-2.32.3-2.3-1.4-2.62.6-2.30.92.7-0.6-0.90.5-0.4-0.90.91.1-2.1
Pavlov. Cond. lever latency0.40.51.20.6-0.50.8-0.6-0.6-0.60.7-0.60.6-0.6-0.8-0.50.5-0.70.80.4-0.9-1.01.1-1.1-0.70.8-0.4-0.0
Pavlov. Cond. magazine entry latency0.30.41.6-1.10.4-0.50.40.40.4-0.40.3-0.30.30.90.3-0.30.1-1.20.01.31.0-0.80.70.7-0.60.5-0.8
Pavlov. Cond. change in total contacts0.30.32.2-0.80.2-0.60.20.20.2-0.20.2-0.20.20.40.1-0.10.1-0.80.21.00.5-0.70.60.1-0.01.5-0.7
Pavlov. Cond. index score0.20.20.8-0.70.3-0.60.40.40.4-0.40.3-0.30.30.50.2-0.20.3-0.6-0.30.60.5-0.50.50.3-0.30.9-0.0
Pavlov. Cond. latency score0.10.10.3-0.50.2-0.40.30.30.3-0.30.2-0.20.20.50.1-0.10.2-0.6-0.10.60.6-0.60.60.4-0.40.5-0.2
Pavlov. Cond. lever contacts0.10.10.3-0.20.1-0.20.10.10.1-0.10.1-0.10.10.3-0.00.00.1-0.3-0.00.30.4-0.50.60.2-0.30.4-0.3
Pavlov. Cond. magazine entry number0.20.31.20.9-0.50.8-0.6-0.6-0.60.5-0.50.5-0.5-0.4-0.50.5-0.50.60.5-0.7-0.30.2-0.2-0.20.2-1.1-0.3
Pavlov. Cond. intertrial magazine entries0.50.61.90.7-0.80.6-0.8-0.7-0.70.8-0.40.4-0.4-1.2-0.40.4-0.50.90.6-0.8-1.10.9-0.9-1.31.40.9-0.1
Pavlov. Cond. lever-magazine prob. diff.0.40.51.0-1.00.6-0.80.60.60.6-0.60.6-0.60.60.80.5-0.50.6-0.9-0.51.00.8-0.80.80.5-0.51.0-0.1
Pavlov. Cond. response bias0.10.21.5-0.60.3-0.50.30.30.3-0.30.3-0.30.30.30.3-0.30.3-0.4-0.20.50.3-0.20.20.1-0.11.20.1
Pavlov. Cond. lever latency0.70.91.90.8-0.81.3-0.8-0.8-0.80.9-0.90.9-0.9-0.8-0.90.9-1.21.00.7-1.0-0.91.2-1.4-0.80.8-1.3-0.5
Pavlov. Cond. magazine entry latency3.74.36.5-2.52.1-2.22.12.12.1-2.02.3-2.32.32.32.4-2.42.1-2.4-1.82.42.2-1.91.61.8-1.70.40.0
Pavlov. Cond. change in total contacts2.33.15.5-2.21.6-2.31.61.61.6-1.61.9-1.91.91.71.8-1.81.8-2.2-1.22.31.7-1.81.71.2-1.22.0-0.0
Pavlov. Cond. index score2.83.65.2-2.21.8-2.31.81.81.8-1.82.0-2.02.01.92.1-2.12.0-2.2-1.52.21.9-2.01.91.5-1.51.60.2
Pavlov. Cond. latency score2.43.04.5-1.91.6-2.11.61.61.6-1.61.8-1.81.81.71.9-1.91.9-2.0-1.32.11.8-2.02.01.3-1.31.80.2
Pavlov. Cond. lever contacts0.60.81.6-0.70.9-1.20.90.80.8-0.90.9-0.90.90.60.9-0.91.3-0.6-0.90.60.5-0.80.90.7-0.71.01.0
Pavlov. Cond. magazine entry number6.47.812.03.5-3.03.1-3.0-3.0-3.02.8-3.13.1-3.1-3.0-3.23.2-2.93.32.5-3.2-2.82.4-2.0-2.32.2-0.4-0.6
Pavlov. Cond. intertrial magazine entries1.11.42.21.5-1.41.2-1.4-1.4-1.41.1-1.51.5-1.4-1.3-1.41.4-1.11.31.2-1.2-1.20.8-0.5-0.90.90.4-0.1
Pavlov. Cond. lever-magazine prob. diff.3.34.15.8-2.42.0-2.42.02.02.0-2.02.2-2.22.22.12.3-2.32.2-2.4-1.72.42.1-2.12.01.6-1.61.40.3
Pavlov. Cond. response bias1.92.64.0-1.81.7-2.01.71.71.7-1.71.8-1.81.81.51.8-1.81.9-1.7-1.51.61.4-1.41.41.4-1.40.90.7
Time in closed arm before self-admin0.10.21.7-0.30.2-0.50.10.30.3-0.20.2-0.20.20.2-0.00.00.2-0.40.00.50.3-0.60.50.2-0.21.3-0.2
Time in closed arm after self-admin0.00.00.10.2-0.00.3-0.0-0.2-0.20.30.0-0.00.00.0-0.10.1-0.10.00.20.10.20.10.00.1-0.10.10.4
Time in open arm before self-admin0.91.03.80.7-0.91.6-0.8-0.8-0.80.8-0.90.9-0.9-0.6-0.70.7-1.21.00.5-1.1-0.61.5-1.7-0.60.7-2.00.0
Time in open arm after self-admin0.40.41.60.4-0.50.7-0.5-0.4-0.40.4-0.50.5-0.5-0.7-0.40.4-0.60.80.1-0.9-0.91.1-1.3-0.70.7-0.9-0.2
Bone: periosteal estimation0.20.43.50.3-0.1-0.7-0.2-0.3-0.30.2-0.00.0-0.00.2-0.00.00.6-0.50.40.70.6-1.61.90.2-0.31.4-0.4
Bone: periosteal perimeter0.30.42.3-0.20.3-0.90.30.20.2-0.20.4-0.40.40.50.4-0.40.8-0.8-0.00.90.7-1.41.50.7-0.70.3-0.1
Bone: post-yield work2.33.211.0-1.60.7-1.50.70.70.7-0.70.6-0.60.62.00.6-0.60.5-3.00.83.32.6-3.33.21.8-1.72.2-1.9
Progressive ratio test 1 active lever presses2.62.74.51.8-2.11.7-2.0-1.9-1.91.9-1.71.7-1.7-1.8-1.61.6-1.71.51.9-1.4-1.71.4-1.4-1.21.20.6-1.1
Progressive ratio test 1 breakpoint2.42.54.11.8-2.01.6-1.9-1.8-1.81.8-1.61.6-1.6-1.8-1.51.5-1.51.61.8-1.5-1.71.5-1.5-1.21.30.5-1.0
Progressive ratio test 1 inactive lever presses1.11.22.11.0-1.31.4-1.3-1.2-1.21.3-1.21.2-1.2-1.1-1.11.1-1.41.01.3-0.9-1.01.2-1.2-0.60.7-0.0-0.8
Progressive ratio test 2 active lever presses3.53.76.42.3-2.51.8-2.4-2.2-2.22.4-2.12.1-2.1-2.3-1.81.8-1.81.72.5-1.5-2.01.3-1.1-1.51.51.6-1.0
Progressive ratio test 2 breakpoint4.75.38.22.7-2.92.3-2.7-2.5-2.52.7-2.42.4-2.4-2.8-2.22.2-2.12.32.6-2.1-2.62.0-1.8-2.02.01.4-0.6
Progressive ratio test 2 inactive lever presses7.28.413.33.0-3.43.0-3.5-3.2-3.23.4-3.33.3-3.3-3.2-3.13.1-3.22.53.7-2.2-2.91.8-1.6-2.02.11.7-2.3
Incentive Sensitization - Responses0.30.32.40.6-0.80.4-0.7-0.6-0.60.8-0.50.5-0.5-0.7-0.30.3-0.30.20.9-0.1-0.50.10.0-0.50.51.5-0.2
Incentive Sensitization - Breakpoint0.50.52.40.8-1.00.5-0.9-0.8-0.81.0-0.60.6-0.6-0.9-0.50.5-0.50.41.0-0.3-0.70.2-0.1-0.70.71.6-0.3
Sum of active levers in priming session hrs 5-61.91.87.0-0.91.3-2.01.41.21.2-1.21.4-1.41.40.41.5-1.52.0-0.6-1.60.60.2-0.60.90.4-0.52.02.6
Progressive ratio2.93.46.7-2.11.6-1.81.51.51.5-1.71.5-1.51.52.41.4-1.41.4-2.5-0.92.52.6-2.22.02.6-2.50.40.1
Food seeking constrained by brief footshock0.20.21.6-0.20.5-0.10.50.40.4-0.30.5-0.50.50.30.6-0.60.5-0.2-0.60.10.30.2-0.40.3-0.3-0.31.3
Seeking ratio, punishment vs. effort2.53.15.62.0-1.52.0-1.4-1.4-1.41.6-1.41.4-1.4-2.1-1.31.3-1.52.30.8-2.4-2.22.3-2.3-2.32.3-1.10.1
Retroperitoneal fat weight4.715.421.54.3-4.54.0-4.5-4.6-4.64.6-4.44.4-4.4-3.9-4.54.5-4.13.44.6-3.1-3.32.5-2.2-3.53.41.4-3.0
Reaction time number correct0.30.53.7-0.20.5-0.70.60.60.6-0.80.7-0.70.70.30.6-0.61.0-0.2-1.00.00.20.10.00.5-0.60.11.9
Reaction time mean minus median3.24.26.9-2.42.2-2.62.22.22.2-2.12.1-2.12.02.12.1-2.12.2-2.2-1.82.22.0-2.12.21.5-1.61.31.1
Reaction time mean minus median AUC1.62.13.7-1.61.5-1.91.61.61.6-1.61.6-1.61.51.31.6-1.61.8-1.3-1.51.31.2-1.21.31.0-1.01.11.2
Reaction time num false alarms0.30.41.10.8-0.41.0-0.4-0.5-0.50.7-0.40.4-0.3-0.6-0.40.4-0.41.10.2-1.0-0.60.8-0.8-0.80.8-0.20.1
Reaction time num false alarms AUC0.10.10.30.10.30.30.20.10.1-0.00.3-0.30.40.00.3-0.30.20.4-0.4-0.30.10.3-0.3-0.30.30.10.5
Reaction time trials correct on left0.30.53.7-0.20.5-0.70.60.60.6-0.80.7-0.70.70.30.6-0.61.0-0.2-1.00.00.20.10.00.5-0.60.11.9
Reaction time trials on left0.40.64.3-0.30.6-0.80.70.70.7-0.90.8-0.80.80.40.7-0.71.1-0.2-1.10.00.30.10.10.5-0.60.22.1
Reaction time mean0.10.10.8-0.60.2-0.50.40.40.4-0.30.1-0.10.00.10.2-0.20.2-0.3-0.00.30.0-0.00.10.1-0.10.90.2
Reaction time mean AUC0.10.11.2-0.60.2-0.50.40.30.3-0.2-0.00.0-0.00.10.1-0.10.1-0.40.10.40.1-0.10.10.1-0.11.10.2
Median of all reaction times0.10.10.5-0.2-0.30.00.0-0.0-0.00.2-0.40.4-0.4-0.2-0.30.3-0.40.00.40.0-0.30.3-0.3-0.20.20.7-0.2
Reaction time omissions1.21.72.9-1.71.3-1.51.31.31.3-1.31.5-1.51.41.31.4-1.41.4-1.3-1.31.31.2-1.01.00.9-0.80.61.2
Reaction time false alarm rate0.20.30.80.6-0.30.9-0.4-0.5-0.50.7-0.40.4-0.3-0.4-0.40.4-0.50.80.4-0.6-0.30.3-0.3-0.70.80.0-0.6
Reaction time premature initiation rate1.92.64.9-1.51.9-1.31.91.91.9-1.91.8-1.81.91.71.8-1.81.7-0.9-2.20.71.4-0.50.41.4-1.4-1.61.4
Reaction time premature initiations3.14.48.7-1.92.4-1.92.42.52.5-2.52.5-2.52.52.02.4-2.42.4-1.2-2.90.91.6-0.40.41.7-1.8-1.42.6
Std. dev. reaction times0.81.12.1-1.41.2-1.51.31.21.2-1.21.0-1.00.91.01.1-1.11.1-1.1-0.91.10.9-0.90.90.6-0.71.00.9
Reaction time trials completed0.40.64.3-0.30.6-0.80.70.70.7-0.90.8-0.80.80.40.7-0.71.1-0.2-1.10.00.30.10.10.5-0.60.22.1
Reaction time trials AUC0.30.43.5-0.10.4-0.60.50.50.5-0.60.6-0.60.60.30.5-0.50.9-0.1-0.9-0.10.20.2-0.00.4-0.50.11.9
Run reversals in cocaine runway, females0.80.72.6-0.80.6-0.20.50.60.6-0.60.6-0.60.61.40.7-0.70.3-1.3-0.21.41.6-1.21.11.0-1.0-0.1-0.7
Run reversals in cocaine runway, males0.60.62.21.2-0.50.4-0.5-0.5-0.50.5-0.50.5-0.5-1.1-0.40.40.01.4-0.1-1.5-1.20.9-0.7-1.11.00.20.6
Latency to leave start box in cocaine runway0.20.32.0-0.2-0.0-0.0-0.2-0.2-0.20.20.0-0.00.00.3-0.00.0-0.1-0.60.50.80.5-0.80.80.1-0.01.1-1.4
Latency to leave start box in cocaine runway, F0.10.22.0-0.60.1-0.0-0.10.00.0-0.00.1-0.10.10.30.1-0.1-0.3-0.50.30.60.4-0.40.1-0.20.30.2-1.4
Latency to leave start box in cocaine runway, M0.20.22.00.30.0-0.20.0-0.2-0.20.20.2-0.20.20.10.1-0.10.5-0.20.10.40.3-0.71.00.4-0.41.4-0.2
Std. dev. time between licks in bursts0.20.32.20.7-0.10.7-0.1-0.1-0.10.2-0.20.2-0.3-0.3-0.30.3-0.31.0-0.2-1.1-0.40.6-0.6-0.20.1-1.50.4
Total sessions with >9 infusions1.31.43.01.5-1.51.4-1.5-1.4-1.41.5-1.31.3-1.3-0.9-1.31.3-1.30.81.7-0.7-0.60.00.1-0.40.41.0-1.5
Short access day 1 total inactive lever presses3.13.55.42.0-2.12.2-2.2-2.1-2.12.3-2.12.1-2.1-1.9-2.02.0-2.11.72.3-1.6-1.71.5-1.3-1.21.20.4-1.2
Short access day 10 total inactive lever presses3.64.06.32.1-2.02.5-2.1-2.1-2.12.2-2.12.1-2.1-2.1-2.02.0-2.32.12.0-2.0-2.02.1-2.0-1.51.5-0.5-0.9
Short access day 1 total infusions2.12.35.51.4-2.01.8-1.9-1.8-1.81.8-1.81.8-1.8-1.1-1.71.7-1.90.72.4-0.5-0.60.4-0.4-0.80.80.6-2.1
Short access day 10 total infusions1.11.24.20.8-1.51.0-1.4-1.4-1.41.4-0.90.9-0.9-0.3-0.90.9-1.0-0.32.10.60.2-0.70.70.3-0.21.5-1.9
Short access total infusions0.91.03.11.1-1.51.2-1.4-1.3-1.31.3-1.11.1-1.1-0.5-1.01.0-1.10.21.8-0.0-0.1-0.40.50.1-0.01.0-1.6
Short access day 1 locomotion1.81.94.41.5-1.81.7-1.8-1.8-1.81.8-1.61.6-1.6-1.1-1.21.2-1.50.72.1-0.6-0.7-0.30.4-0.50.60.6-2.0
Short access day 10 total locomotion1.31.46.11.1-1.61.4-1.5-1.5-1.51.5-1.21.2-1.2-0.8-1.11.1-1.30.41.9-0.2-0.4-0.20.2-0.50.60.4-2.5
Short access total locomotion1.11.15.41.0-1.51.3-1.4-1.3-1.31.3-1.11.1-1.1-0.6-0.90.9-1.20.31.7-0.1-0.2-0.50.6-0.20.20.6-2.3
One hour access (0.3 mA shock)9.210.715.33.8-3.93.4-3.9-3.7-3.73.7-3.73.7-3.7-3.7-3.43.4-3.33.23.7-3.1-3.42.7-2.4-2.52.50.9-1.4
Compulsive drug intake2.02.17.4-1.61.7-0.91.71.71.7-1.71.6-1.61.61.41.6-1.61.3-0.9-2.00.71.00.1-0.50.6-0.5-2.70.7
One hour access (shock baseline)7.68.913.23.4-3.62.6-3.6-3.5-3.53.5-3.33.3-3.3-3.4-3.13.1-2.92.83.6-2.5-3.11.9-1.4-2.32.32.4-1.3
Social response proportion0.91.01.6-1.11.3-1.11.11.11.1-1.10.8-0.80.91.01.0-1.00.9-1.0-0.91.00.9-0.80.71.3-1.3-0.80.3
Social responses0.20.30.7-0.30.7-0.40.60.60.6-0.40.4-0.40.50.30.7-0.70.6-0.1-0.70.10.2-0.20.10.7-0.7-0.90.5
Social time0.30.41.7-0.30.6-0.50.70.60.6-0.70.4-0.40.50.50.8-0.80.9-0.2-0.90.00.3-0.20.00.8-0.8-1.31.1
Soleus weight3.811.215.13.7-3.73.5-3.7-3.7-3.73.7-3.93.9-3.9-3.5-3.83.8-3.53.43.5-3.2-3.12.4-2.0-3.13.00.0-1.7
Bone: stiffness3.35.38.6-2.52.2-2.62.22.22.2-2.22.1-2.12.12.62.2-2.22.2-2.9-1.52.92.7-2.92.82.3-2.31.50.2
Tibialis anterior weight10.234.752.4-5.76.5-6.86.56.56.5-6.66.6-6.66.65.76.7-6.77.2-5.1-6.64.85.3-5.15.14.6-4.71.64.1
Time to tail flick, vehicle, before self-admin0.70.72.0-0.70.6-0.90.60.80.8-0.70.7-0.70.71.00.6-0.60.8-1.0-0.41.01.1-1.31.40.9-0.90.70.8
Time to tail flick, vehicle, after self-admin1.51.63.3-1.11.1-1.01.11.21.2-1.31.0-1.01.01.71.2-1.21.1-1.4-0.91.31.8-1.81.71.5-1.4-0.4-0.4
Time to tail flick, test, before self-admin0.60.51.40.7-0.91.0-0.9-0.8-0.80.8-1.01.0-1.0-0.1-0.60.6-0.90.21.2-0.20.2-0.20.20.00.0-0.9-1.0
Time to tail flick, test, after self-admin0.00.00.30.10.1-0.10.10.10.1-0.2-0.10.1-0.1-0.00.0-0.00.00.2-0.2-0.3-0.1-0.10.2-0.10.1-0.50.4
Delta time to tail flick, vehicle, before/after SA0.50.40.9-0.60.7-0.40.60.60.6-0.70.4-0.40.40.90.7-0.70.5-0.7-0.50.60.9-0.80.70.8-0.8-0.9-0.7
Delta time to tail flick, test, before/after SA0.90.82.7-0.81.1-1.21.11.11.1-1.21.1-1.11.10.30.8-0.81.2-0.1-1.6-0.1-0.20.1-0.10.0-0.00.21.6
Tibia length1.23.37.9-1.51.8-2.81.81.81.8-1.82.0-2.02.01.21.8-1.82.6-1.6-1.81.61.1-1.92.10.9-1.01.91.5
Ambulatory time before self-admin0.50.51.4-0.80.7-1.20.70.70.7-0.70.6-0.60.60.60.6-0.60.8-0.9-0.50.90.6-0.91.00.5-0.51.10.1
Ambulatory time after self-admin0.10.10.6-0.2-0.1-0.1-0.0-0.2-0.20.3-0.20.2-0.2-0.1-0.30.3-0.4-0.40.50.50.0-0.10.1-0.10.10.3-0.8
Bone: tissue strength0.10.10.2-0.30.2-0.30.20.20.2-0.40.1-0.10.10.20.2-0.20.1-0.4-0.00.40.2-0.30.30.0-0.0-0.30.3
Total heroin consumption5.56.48.7-3.02.8-2.82.82.82.8-2.82.8-2.82.92.72.7-2.72.7-2.7-2.62.62.5-2.11.82.0-2.0-0.01.4
Bone: trabecular number0.81.33.4-1.20.9-1.10.80.70.7-0.50.9-0.90.91.21.0-1.00.9-1.7-0.21.81.4-1.61.51.4-1.30.8-0.8
Bone: trabecular spacing0.30.40.90.6-0.60.9-0.5-0.5-0.50.3-0.60.6-0.6-0.6-0.60.6-0.70.80.3-0.9-0.60.9-0.9-0.60.6-0.30.1
Bone: trabecular thickness0.40.52.50.4-0.60.7-0.8-0.9-0.91.0-0.70.7-0.7-0.4-0.60.6-0.9-0.01.10.2-0.2-0.10.0-0.10.2-0.4-1.6
Bone: trabecular tissue density3.65.06.32.4-2.42.1-2.3-2.3-2.32.3-2.52.5-2.5-2.5-2.42.4-2.32.42.1-2.3-2.41.9-1.7-2.42.4-0.8-1.0
Water consumed over 24 hours0.60.81.7-1.21.0-0.61.01.11.1-1.11.0-1.01.00.81.0-1.00.6-0.7-1.10.60.50.3-0.60.8-0.7-1.30.6
Number of responses in last shaping day1.31.32.11.3-1.41.4-1.3-1.2-1.21.3-1.11.1-1.1-1.4-1.01.0-1.11.41.0-1.3-1.41.0-1.0-0.90.9-0.7-0.8