Hub : Genes

Znrd2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA intron excision ratio chr1_212447710_212448242 0.35 0.11 0.0e+00 0.4 0.41 0.4 0.41 8.7e-34 2.7e-35 5.9e-34 5.2e-35
2 Brain intron excision ratio chr1_212447710_212448005 0.22 0.09 0.0e+00 0.29 0.27 0.28 0.28 7.1e-27 3.6e-25 3.2e-26 4.4e-26
3 IC intron excision ratio chr1_212447710_212448242 0.27 0.11 8.0e-11 0.16 0.16 0.15 0.12 3.0e-07 3.5e-07 6.0e-07 1.3e-05
4 pVTA gene expression Znrd2 0.1 0.05 1.3e-09 0.12 0.12 0.12 0.12 7.3e-10 1.4e-09 1.2e-09 9.9e-10
5 Brain intron excision ratio chr1_212447710_212448242 0.33 0.1 0.0e+00 0.42 0.42 0.42 0.43 1.0e-42 3.5e-42 1.6e-42 1.3e-43
6 IC gene expression Znrd2 0.42 0.14 2.2e-16 0.27 0.26 0.25 0.26 1.2e-11 1.6e-11 9.9e-11 3.3e-11
7 BLA gene expression Znrd2 0.22 0.1 6.0e-13 0.23 0.23 0.23 0.22 1.8e-12 2.3e-12 3.2e-12 6.2e-12
8 PL alternative polyA NM_001109537.2 0.04 0.03 6.6e-05 0.04 0.04 0.03 0.04 3.9e-05 6.0e-05 3.9e-04 4.6e-05
9 PL alternative polyA XM_063274608.1 0.04 0.03 1.0e-04 0.04 0.03 0.03 0.03 8.7e-05 1.1e-04 6.8e-04 1.6e-04
10 PL gene expression Znrd2 0.24 0.09 0.0e+00 0.34 0.34 0.34 0.34 5.1e-39 9.6e-38 1.5e-38 8.1e-39
11 OFC intron excision ratio chr1_212447710_212448242 0.22 0.12 1.0e-03 0.08 0.13 0.1 0.1 6.3e-03 5.5e-04 2.1e-03 2.8e-03
12 NAcc gene expression Znrd2 0.17 0.07 0.0e+00 0.22 0.21 0.22 0.21 1.3e-32 4.0e-31 6.9e-32 1.1e-31
13 Adipose intron excision ratio chr1_212447710_212448242 0.05 0.03 2.8e-04 0.01 0.01 0.01 0.01 3.9e-02 7.6e-03 1.5e-02 4.5e-02
14 Brain gene expression Znrd2 0.25 0.1 0.0e+00 0.25 0.25 0.25 0.26 3.7e-23 1.9e-23 4.1e-23 6.3e-24
15 IL gene expression Znrd2 0.6 0.18 7.9e-07 0.12 0.18 0.2 0.19 7.4e-04 4.0e-05 1.3e-05 3.2e-05
16 LHb gene expression Znrd2 0.21 0.11 9.5e-05 0.11 0.22 0.15 0.16 1.3e-03 6.8e-06 2.3e-04 1.3e-04
17 OFC gene expression Znrd2 0.25 0.13 1.1e-04 0.18 0.12 0.19 0.18 4.0e-05 9.4e-04 2.9e-05 5.3e-05
18 pVTA mRNA stability Znrd2 0.04 0.03 9.8e-04 0.05 0.04 0.04 0.04 1.1e-04 4.3e-04 5.3e-04 6.6e-04
19 Brain mRNA stability Znrd2 0.04 0.03 2.0e-03 0.04 0.03 0.04 0.03 2.3e-04 1.5e-03 2.8e-04 4.3e-04
20 Adipose isoform ratio NM_001109537.2 0.08 0.05 4.1e-03 0.02 0 0.01 0.01 2.4e-03 3.6e-01 2.7e-02 3.4e-02
21 Liver gene expression Znrd2 0.04 0.03 9.5e-04 0.01 0.01 0.01 0.01 7.0e-03 1.4e-02 6.6e-02 1.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.50.93.41.2-0.81.0-1.00.9-0.9-0.8-0.80.8-0.81.5-1.01.6-0.1-0.00.0-0.90.10.70.61.8
Area under the delay curve0.30.31.40.10.2-0.20.2-0.20.00.40.4-0.40.40.50.30.30.70.80.60.50.21.21.01.1
BMI with tail2.06.923.23.3-2.62.8-2.82.5-2.4-2.4-2.42.4-2.43.7-2.54.3-1.2-1.1-0.4-2.11.71.51.44.8
BMI without tail0.92.810.32.1-1.51.9-1.91.6-1.5-1.5-1.51.5-1.52.6-1.62.7-0.6-0.3-0.4-1.00.91.11.13.2
Body weight2.711.819.84.1-3.73.9-3.93.7-3.7-3.8-3.83.8-3.84.1-3.64.4-2.9-3.2-2.6-3.8-0.7-1.1-1.13.1
Weight adjusted by age1.32.03.81.4-1.41.6-1.61.5-1.5-1.3-1.31.3-1.31.1-1.41.1-1.6-2.0-1.5-1.8-1.0-1.4-1.6-0.0
Bone surface4.37.811.73.3-3.03.2-3.23.1-3.1-3.1-3.13.1-3.13.2-3.13.4-2.3-2.3-1.9-3.4-1.4-1.3-1.42.0
Bone volume1.52.65.22.1-1.61.9-1.91.8-1.8-1.7-1.71.7-1.72.0-1.82.3-1.1-1.1-0.7-2.0-0.5-0.3-0.41.8
Breakpoint value in progressive ratio session3.23.85.22.2-2.22.3-2.32.2-2.0-2.1-2.12.1-2.12.0-2.22.0-2.1-2.0-1.6-1.9-1.5-1.3-1.51.0
Number of licking bursts0.30.40.80.7-0.60.9-0.90.7-0.6-0.8-0.80.8-0.80.6-0.80.6-0.7-0.8-0.5-0.6-0.2-0.5-0.50.3
Context. condit. distance diff. score2.12.53.3-1.61.7-1.81.8-1.81.61.71.7-1.71.7-1.41.8-1.31.71.71.61.51.21.51.4-0.1
Locomotion velocity, session 10.00.00.1-0.10.1-0.00.0-0.1-0.10.10.1-0.10.1-0.10.0-0.1-0.1-0.3-0.4-0.2-0.3-0.2-0.2-0.3
Locomotion distance, session 10.60.73.11.0-0.70.8-0.80.7-0.8-0.7-0.70.7-0.71.3-0.81.4-0.2-0.2-0.2-0.60.80.60.61.8
Locomotion velocity, session 22.63.05.02.1-1.91.9-1.91.9-1.9-1.8-1.81.8-1.82.1-2.02.2-1.6-1.7-1.4-1.9-0.3-0.5-0.51.6
Locomotion distance, session 20.71.02.91.2-1.01.1-1.11.0-1.0-0.9-0.90.9-0.91.6-1.01.5-0.5-0.5-0.5-0.70.70.30.31.7
Locomotion velocity, session 30.30.41.5-0.20.2-0.40.4-0.30.40.50.5-0.50.5-0.00.30.40.50.20.70.21.21.21.11.2
Locomotion distance, session 30.00.00.0-0.1-0.0-0.10.1-0.10.20.20.2-0.20.2-0.10.1-0.10.1-0.10.10.10.00.20.10.2
Stereotopy head waving bouts, day 30.91.14.1-0.60.9-1.11.1-1.00.90.80.8-0.80.8-0.41.1-0.01.20.81.10.62.01.51.51.0
Stereotopy head waving duration, day 30.91.12.1-0.81.1-1.31.3-1.20.90.90.9-0.90.9-0.61.3-0.41.31.11.20.71.41.21.30.4
Locomotion velocity, session 70.91.03.8-0.20.7-0.50.5-0.50.60.70.7-0.70.70.10.50.40.91.11.31.02.01.81.81.7
Locomotion distance, session 70.20.31.70.10.10.0-0.00.00.2-0.0-0.00.0-0.00.50.10.50.30.40.30.61.20.91.01.3
Stereotopy head waving bouts, day 70.10.10.40.00.2-0.30.3-0.20.10.20.2-0.20.20.00.10.20.40.40.60.00.40.50.50.5
Stereotopy head waving duration, day 70.50.61.21.1-0.80.7-0.70.8-1.0-0.7-0.70.7-0.71.1-0.91.1-0.5-0.4-0.2-0.8-0.30.0-0.01.0
Locomotion velocity, session 80.91.12.00.9-1.21.1-1.11.1-1.0-1.1-1.11.1-1.10.9-1.10.8-1.1-1.3-1.4-1.3-0.7-1.1-1.1-0.0
Locomotion distance, session 80.40.62.4-0.40.6-0.60.6-0.70.50.60.6-0.60.6-0.20.70.10.80.60.90.21.51.21.21.0
Degree of sensitization distance0.20.31.80.30.10.1-0.10.0-0.0-0.2-0.20.2-0.20.50.00.70.30.30.30.11.30.70.81.1
Degree of sensitization stereotypy0.30.40.70.8-0.70.6-0.60.7-0.7-0.6-0.60.6-0.60.7-0.80.8-0.6-0.5-0.1-0.7-0.5-0.2-0.20.6
Conditioned locomotion1.61.82.81.4-1.41.4-1.41.4-1.4-1.4-1.41.4-1.41.3-1.41.3-1.4-1.6-1.4-1.7-1.0-1.1-1.10.3
Cocaine response after cond. corrected1.41.62.4-1.31.6-1.41.4-1.41.41.41.4-1.41.4-1.21.3-1.11.31.11.01.31.21.21.2-0.3
Cocaine response after cond. not corrected1.01.11.7-1.11.3-1.11.1-1.21.21.21.2-1.21.2-1.01.1-0.91.10.80.91.11.11.00.9-0.2
Cocaine response before conditioning0.80.91.41.0-1.11.2-1.21.1-1.0-1.0-1.01.0-1.00.8-1.00.8-1.1-1.0-0.7-0.8-0.6-0.9-0.90.3
Saline control response3.95.26.62.5-2.62.5-2.52.5-2.5-2.5-2.52.5-2.52.4-2.62.3-2.2-2.2-2.4-2.2-1.2-1.8-1.80.8
Bone: connectivity density2.23.56.72.3-2.02.2-2.22.1-2.0-2.0-2.02.0-2.02.5-2.12.6-1.3-1.1-1.1-2.0-0.6-0.3-0.52.0
Bone: cortical apparent density0.10.20.90.2-0.30.3-0.30.3-0.3-0.4-0.40.4-0.40.2-0.4-0.1-0.5-0.2-0.40.3-1.0-0.5-0.5-0.2
Bone: cortical area0.81.32.21.1-1.11.4-1.41.2-1.1-1.1-1.11.1-1.10.8-1.31.0-1.3-1.5-1.0-1.4-0.9-1.0-1.00.1
Bone: cortical porosity0.20.20.60.6-0.40.4-0.40.3-0.5-0.4-0.40.4-0.40.7-0.30.7-0.0-0.2-0.1-0.5-0.20.10.30.8
Bone: cortical porosity0.50.61.21.0-0.70.7-0.70.7-0.9-0.8-0.80.8-0.81.1-0.71.1-0.4-0.6-0.5-0.9-0.3-0.1-0.00.9
Bone: cortical thickness3.25.37.82.0-2.32.6-2.62.5-2.3-2.3-2.32.3-2.31.7-2.61.4-2.8-2.8-2.7-1.8-2.7-2.4-2.4-0.4
Bone: cortical thickness0.70.81.70.6-0.91.0-1.00.9-0.7-0.8-0.80.8-0.80.5-1.00.3-1.1-1.1-1.3-0.4-1.3-1.0-1.0-0.5
Bone: cortical tissue density0.20.31.20.3-0.40.4-0.40.5-0.5-0.6-0.60.6-0.60.3-0.5-0.0-0.7-0.3-0.60.1-1.1-0.7-0.7-0.2
Condit. Reinf. active minus inactive responses0.10.20.50.5-0.40.3-0.30.4-0.4-0.4-0.40.4-0.40.7-0.50.6-0.20.0-0.10.00.40.20.20.7
Condit. Reinf. active-inactive response ratio0.00.00.20.10.0-0.10.10.0-0.1-0.0-0.00.0-0.00.2-0.10.00.00.40.00.5-0.40.10.20.2
Condit. Reinf. active responses0.10.20.90.3-0.10.2-0.20.2-0.1-0.1-0.10.1-0.10.4-0.40.5-0.10.10.3-0.01.00.50.50.9
Condit. Reinf. inactive responses0.20.32.5-0.00.2-0.10.1-0.10.30.20.2-0.20.2-0.10.00.40.20.10.6-0.21.60.80.60.8
Incentive salience index mean0.40.41.70.8-0.60.6-0.60.6-0.5-0.6-0.60.6-0.61.0-0.71.1-0.3-0.1-0.1-0.40.70.40.51.3
Condit. Reinf. lever presses0.50.71.51.0-0.90.9-0.90.8-0.7-0.9-0.90.9-0.90.9-0.91.2-0.7-0.7-0.3-1.10.4-0.0-0.01.0
Condit. Reinf. active minus inactive responses0.00.00.2-0.10.1-0.10.1-0.10.20.20.2-0.20.2-0.20.1-0.10.30.40.40.00.20.10.00.1
Condit. Reinf. active-inactive response ratio0.50.61.4-0.70.8-0.70.7-0.80.80.80.8-0.80.8-0.90.7-0.50.80.61.20.31.00.70.60.0
Condit. Reinf. active responses0.10.20.40.5-0.50.5-0.50.5-0.4-0.4-0.40.4-0.40.6-0.50.5-0.10.20.0-0.2-0.10.0-0.00.6
Condit. Reinf. inactive responses0.50.61.70.9-0.90.9-0.90.9-0.8-0.9-0.90.9-0.91.3-0.80.9-0.5-0.1-0.6-0.2-0.4-0.1-0.10.9
Condit. Reinf. lever presses2.02.84.01.9-1.91.9-1.91.9-1.7-1.8-1.81.8-1.81.6-2.01.7-1.6-1.6-1.2-1.9-1.1-1.2-1.20.7
Condit. Reinf. lever reinforcers received0.30.40.70.8-0.80.8-0.80.8-0.7-0.8-0.80.8-0.80.9-0.80.7-0.5-0.1-0.3-0.5-0.4-0.4-0.40.5
Conditioned reinforcement - actives0.10.21.0-0.10.00.2-0.20.0-0.0-0.1-0.10.1-0.1-0.6-0.1-0.3-0.2-0.7-0.1-0.6-0.1-0.9-0.8-1.0
Conditioned reinforcement - inactives2.33.35.8-2.12.0-1.91.9-1.92.12.02.0-2.02.0-2.41.8-2.21.71.81.91.60.70.80.6-1.6
Conditioned locomotion7.19.313.3-3.53.3-3.33.3-3.33.33.33.3-3.33.3-3.63.3-3.52.93.02.93.31.61.61.6-2.2
Patch foraging indifference point 0 sec0.00.00.2-0.1-0.2-0.10.1-0.00.3-0.0-0.00.0-0.00.00.30.00.10.40.30.40.20.10.20.2
Patch foraging indifference point AUC2.43.54.61.8-2.01.9-1.91.9-2.0-2.1-2.12.1-2.11.5-2.01.4-2.0-1.8-1.7-1.7-2.1-1.9-1.80.1
Delay disc. indifference point, 0s delay0.91.03.1-0.41.0-0.80.8-1.00.40.70.7-0.70.70.11.00.11.41.31.00.80.91.71.71.4
Delay disc. indifference point, 16s delay0.80.81.8-0.70.8-0.80.8-0.71.01.01.0-1.01.0-0.50.8-0.60.91.31.21.10.71.30.90.7
Delay disc. indifference point, 2s delay0.20.20.6-0.20.4-0.40.4-0.40.30.50.5-0.50.5-0.20.1-0.00.60.40.60.50.80.70.70.4
Delay disc. indifference point, 24s delay0.10.10.2-0.30.3-0.30.3-0.30.10.50.5-0.50.5-0.10.5-0.30.20.1-0.10.2-0.20.3-0.1-0.1
Delay disc. indifference point, 4s delay0.30.31.3-0.20.3-0.40.4-0.40.20.40.4-0.40.40.30.40.20.80.80.50.80.71.11.00.8
Delay disc. indifference point, 8s delay0.20.20.7-0.00.2-0.20.2-0.3-0.00.30.3-0.30.30.40.50.20.60.70.30.2-0.10.80.80.6
Indifference point function ln k6.511.314.4-3.63.6-3.63.6-3.63.83.83.8-3.83.8-3.23.7-3.03.43.13.03.33.32.92.8-0.9
Indifference point function log k6.511.314.4-3.63.6-3.63.6-3.63.83.83.8-3.83.8-3.23.7-3.03.43.13.03.33.32.92.8-0.9
Patch foraging total patch changes 0 sec0.00.00.1-0.1-0.2-0.00.00.10.1-0.1-0.10.1-0.1-0.00.2-0.1-0.10.1-0.10.2-0.1-0.2-0.2-0.2
Patch foraging total patch changes 12 sec4.76.18.62.7-2.92.8-2.82.8-2.6-2.8-2.82.8-2.82.7-2.72.5-2.5-2.0-2.1-2.1-1.8-1.6-1.51.4
Patch foraging total patch changes 18 sec0.50.81.21.0-1.01.0-1.01.0-1.0-1.1-1.11.1-1.11.0-1.01.0-0.9-0.7-0.5-0.8-0.5-0.5-0.40.7
Patch foraging total patch changes 24 sec1.73.04.01.6-1.91.7-1.71.8-1.8-2.0-2.02.0-2.01.4-1.61.3-1.9-1.7-1.9-1.5-1.6-2.0-1.8-0.2
Patch foraging total patch changes 6 sec1.11.72.71.4-1.71.5-1.51.6-1.2-1.5-1.51.5-1.51.4-1.51.4-1.3-0.9-1.1-0.8-0.6-0.8-0.80.9
Patch foraging time to switch 0 sec1.22.56.22.1-1.71.7-1.71.7-1.7-1.6-1.61.6-1.62.2-1.62.5-1.0-0.9-0.4-1.60.20.40.32.5
Patch foraging water rate 0 sec2.85.911.5-3.12.7-2.72.7-2.72.72.52.5-2.52.5-3.32.7-3.41.91.71.42.00.50.20.4-2.9
Patch foraging water rate 12 sec6.012.519.8-4.43.9-3.93.9-4.03.74.04.0-4.04.0-4.33.9-4.53.32.82.23.31.51.31.3-3.4
Patch foraging water rate 18 sec2.64.05.7-2.42.4-2.32.3-2.22.22.22.2-2.22.2-2.32.1-2.31.91.51.31.81.31.01.2-1.5
Patch foraging water rate 24 sec4.15.89.1-2.92.8-2.82.8-2.82.52.72.7-2.72.7-3.02.7-3.02.21.71.51.81.30.80.8-2.2
Patch foraging water rate 6 sec3.85.59.1-3.02.7-2.62.6-2.62.62.62.6-2.62.6-3.02.5-3.02.01.61.32.21.20.70.7-2.4
Seeking ratio, delayed vs. immediate footshock0.30.30.9-0.10.1-0.30.3-0.20.50.40.4-0.40.40.20.30.10.50.80.80.80.90.90.91.0
Distance traveled before self-admin0.50.71.21.1-0.90.9-0.90.8-0.9-1.0-1.01.0-1.01.0-0.91.1-0.6-0.5-0.3-1.0-0.4-0.1-0.30.9
Distance traveled after self-admin0.30.31.70.6-0.60.7-0.70.5-0.5-0.5-0.50.5-0.50.5-0.50.4-0.60.0-0.4-0.2-1.3-0.5-0.60.1
Extensor digitorum longus weight7.429.036.96.1-6.05.9-5.95.9-5.9-5.8-5.85.8-5.85.7-5.95.8-5.5-5.6-5.0-5.7-3.3-3.3-3.42.7
Bone: elastic displacement0.80.92.8-1.30.8-0.90.9-0.91.01.01.0-1.01.0-1.40.9-1.50.50.3-0.00.8-0.2-0.3-0.3-1.7
Bone: elastic work1.01.32.50.9-1.21.3-1.31.2-1.0-1.1-1.11.1-1.10.8-1.20.7-1.3-1.4-1.6-1.1-1.3-1.2-1.2-0.2
Bone: endosteal estimation0.91.96.3-0.81.2-1.21.2-1.31.31.21.2-1.21.2-0.71.4-0.01.81.41.90.22.52.01.81.3
Bone: endosteal perimeter1.12.35.8-1.01.6-1.31.3-1.41.51.41.4-1.41.4-0.91.5-0.32.01.62.20.42.42.01.91.0
Epididymis fat weight3.010.313.6-3.43.5-3.63.6-3.63.33.63.6-3.63.6-3.63.7-3.13.32.83.32.02.82.32.2-1.4
Delta time in closed arm before/after self-admin0.10.10.50.3-0.30.3-0.30.3-0.3-0.3-0.30.3-0.30.5-0.40.4-0.3-0.5-0.7-0.4-0.1-0.1-0.10.3
Delta time in open arm before/after self-admin0.30.31.10.4-0.50.5-0.50.5-0.4-0.5-0.50.5-0.50.1-0.30.1-0.5-0.3-0.2-0.6-1.0-0.6-0.7-0.3
Diff in mean of infusions in LGA sessions0.60.71.50.8-0.90.9-0.90.9-0.8-0.7-0.70.7-0.70.7-1.20.6-1.0-0.9-1.0-0.8-0.6-0.9-1.0-0.1
Delay discount exponential model param0.20.21.0-0.1-0.10.1-0.10.10.1-0.3-0.30.3-0.3-0.5-0.2-0.3-0.5-0.6-0.4-0.4-0.1-1.0-0.7-1.0
Extinction: sum of active levers before priming2.42.64.42.0-1.82.0-2.01.8-1.6-1.7-1.71.7-1.72.1-2.02.1-1.5-1.3-1.1-1.1-0.4-0.5-0.51.7
Active lever presses in extinction session 63.33.35.71.9-1.82.0-2.01.8-2.0-1.9-1.91.9-1.91.4-1.91.7-2.0-2.4-1.7-2.2-0.9-1.7-1.70.3
Bone: final force2.54.06.12.2-2.22.2-2.22.2-2.1-2.2-2.22.2-2.22.0-2.12.2-1.9-2.0-1.7-2.5-1.1-1.3-1.40.9
Bone: final moment2.33.65.82.1-2.12.1-2.12.1-2.0-2.1-2.12.1-2.11.9-2.12.1-1.8-2.0-1.6-2.4-1.1-1.2-1.30.9
Food consumed during 24 hour testing period0.20.31.6-0.0-0.10.1-0.10.1-0.3-0.2-0.20.2-0.2-0.3-0.2-0.4-0.4-0.6-0.5-0.3-1.3-0.9-1.0-1.2
Glucose2.84.48.0-1.72.1-2.02.0-2.12.02.02.0-2.02.0-1.22.1-0.92.62.42.51.72.52.82.81.2
Heart weight1.82.77.5-0.91.3-1.41.4-1.41.21.41.4-1.41.4-0.31.40.12.11.91.81.22.62.72.71.9
Delay discount hyperbolic model param0.20.21.0-0.1-0.10.2-0.20.20.0-0.3-0.30.3-0.3-0.4-0.2-0.3-0.6-0.6-0.4-0.4-0.2-1.0-0.8-0.9
Intermittent access intake day 1-15 change0.71.53.3-1.51.4-1.41.4-1.41.31.21.2-1.21.2-1.81.3-1.71.01.01.11.20.40.20.2-1.4
Intermittent access intake escalation0.61.23.0-1.41.2-1.21.2-1.21.21.11.1-1.11.1-1.71.2-1.60.80.80.91.00.2-0.0-0.0-1.5
Intermittent access intake escalation 21.01.12.6-1.31.1-1.21.2-1.21.11.01.0-1.01.0-1.61.2-1.50.80.80.91.00.0-0.00.0-1.3
Intermitt. access day 1 inactive lever presses0.10.20.8-0.40.4-0.50.5-0.40.40.50.5-0.50.5-0.40.5-0.60.30.60.40.9-0.40.30.1-0.3
Intermitt. access day 15 inactive lever presses1.02.13.1-1.51.5-1.51.5-1.41.71.61.6-1.61.6-1.71.2-1.41.41.51.81.21.01.31.1-0.6
Intermitt. access escalation Index2.83.96.6-2.02.2-2.02.0-2.12.12.02.0-2.02.0-1.62.0-1.72.42.62.12.11.71.92.1-0.2
Intermittent access day 1 total infusions2.54.18.5-1.52.0-1.71.7-1.81.91.81.8-1.81.8-1.31.7-0.82.62.52.71.42.92.82.90.8
Intermittent access day 15 total infusions4.46.58.7-2.72.8-2.52.5-2.62.82.72.7-2.72.7-2.92.4-2.52.72.62.92.32.42.02.0-1.1
Intermittent access terminal intake (last 3 days)4.15.48.3-2.42.6-2.32.3-2.42.52.42.4-2.42.4-2.62.2-2.02.62.42.91.82.62.12.1-0.7
Intermittent access total infusions3.64.37.8-1.92.3-1.81.8-1.92.22.12.1-2.12.1-2.01.7-1.42.52.32.71.62.82.32.3-0.1
Intermittent access day 1 locomotion2.32.95.3-1.41.8-1.51.5-1.61.61.61.6-1.61.6-1.21.5-0.92.12.12.21.52.32.22.30.5
Intermittent access day 15 total locomotion2.95.28.1-2.32.5-2.32.3-2.32.52.42.4-2.42.4-2.62.1-2.12.42.52.82.12.02.01.9-0.8
Intermittent access total locomotion6.67.813.2-2.73.0-2.82.8-2.82.92.92.9-2.92.9-2.82.6-2.13.13.23.62.43.12.92.9-0.3
Intermittent access standard deviation0.81.73.3-1.61.6-1.51.5-1.51.41.31.3-1.31.3-1.81.3-1.71.21.21.11.30.20.40.5-1.3
Left kidney weight0.73.34.6-1.61.9-2.12.1-2.01.61.81.8-1.81.8-1.52.1-1.22.02.12.11.31.72.02.10.1
Right kidney weight0.31.32.1-1.31.3-1.41.4-1.41.11.21.2-1.21.2-1.51.4-1.21.10.81.10.70.60.80.8-0.7
Cocaine induced anxiety0.00.00.10.2-0.20.4-0.40.2-0.1-0.0-0.00.0-0.00.1-0.10.1-0.2-0.1-0.0-0.1-0.2-0.2-0.10.0
Post-drug Anxiety0.80.91.51.0-1.21.2-1.21.1-0.9-0.9-0.90.9-0.90.8-0.80.9-1.1-1.1-0.8-0.9-0.4-0.8-1.00.3
Baseline Anxiety0.40.51.00.6-0.90.6-0.60.7-0.7-0.8-0.80.8-0.80.6-0.60.5-0.8-1.0-0.9-0.6-0.4-0.7-0.9-0.0
Tail length0.41.83.61.0-1.01.2-1.21.2-1.4-1.4-1.41.4-1.41.0-1.20.6-1.3-1.3-1.9-1.2-1.8-1.8-1.5-0.6
Length with tail1.98.411.32.8-2.93.0-3.03.0-3.0-3.1-3.13.1-3.12.5-2.92.3-3.0-3.3-3.4-3.2-2.6-2.9-2.70.1
Length without tail2.16.911.52.4-2.72.7-2.72.7-2.7-2.6-2.62.6-2.62.2-2.62.0-2.9-3.4-3.1-3.1-2.3-2.6-2.7-0.1
Times rat made contact with spout0.40.41.10.8-0.60.7-0.70.7-0.7-0.6-0.60.6-0.61.0-0.80.7-0.4-0.1-0.6-0.4-0.9-0.1-0.20.7
Lifetime Intake2.63.26.5-1.61.9-1.51.5-1.61.81.81.8-1.81.8-1.61.4-1.12.22.02.31.42.62.12.10.1
Liver weight, left0.81.32.0-1.31.4-1.31.3-1.41.21.31.3-1.31.3-1.31.3-1.11.20.70.80.80.80.70.7-0.7
Liver weight, right2.13.64.7-2.22.1-2.12.1-2.12.12.12.1-2.12.1-1.92.2-1.82.01.41.51.61.81.51.5-0.8
Locomotor activity1.72.64.6-2.11.8-1.71.7-1.81.91.91.9-1.91.9-2.11.6-2.11.31.00.81.50.40.60.5-1.7
Locomotor testing distance1.93.45.8-2.42.1-2.02.0-2.02.12.22.2-2.22.2-2.31.8-2.41.61.30.91.70.50.70.5-1.8
Locomotor testing rearing1.73.45.0-2.22.1-2.02.0-2.02.02.22.2-2.22.2-1.91.7-2.22.01.81.21.70.21.00.9-1.5
Locomotion in novel chamber5.06.47.9-2.82.8-2.82.8-2.82.72.82.8-2.82.8-2.82.8-2.52.62.42.52.02.21.81.9-1.3
Locomotion in novel chamber post-restriction2.54.15.1-2.22.3-2.12.1-2.12.22.32.3-2.32.3-2.21.9-2.02.12.22.12.11.51.41.5-0.8
Fecal boli incidents, locomotor time 10.00.00.20.1-0.1-0.00.00.0-0.10.00.0-0.00.0-0.3-0.2-0.1-0.3-0.40.2-0.4-0.4-0.2-0.4-0.1
Change in fecal boli incidents, locomotor task0.10.11.00.00.00.1-0.1-0.00.10.10.1-0.10.10.30.20.40.30.1-0.00.11.00.60.40.7
Time >=10cm from walls, locomotor time 10.91.03.2-0.50.7-0.80.8-0.80.70.70.7-0.70.7-0.50.9-0.01.11.11.70.21.81.61.41.0
Bouts of movement, locomotor time 11.61.85.91.3-1.51.4-1.41.3-1.4-1.4-1.41.4-1.41.3-1.20.8-1.4-0.9-1.4-0.7-2.4-1.6-1.50.0
Total resting periods, locomotor time 11.11.24.11.1-1.21.1-1.11.1-1.1-1.1-1.11.1-1.11.0-1.00.6-1.1-0.6-1.0-0.5-2.0-1.2-1.20.1
Rest time, locomotor task time 11.31.62.6-1.51.4-1.51.5-1.41.31.51.5-1.51.5-1.61.3-1.51.10.91.10.90.10.60.5-1.0
Distance moved, locomotor task time 10.20.31.40.6-0.30.5-0.50.4-0.3-0.2-0.20.2-0.20.8-0.40.80.10.10.2-0.31.00.70.81.2
Vertical activity count, locomotor time 10.41.01.3-1.11.1-1.01.0-1.01.11.11.1-1.11.1-1.01.1-0.91.01.01.01.11.10.80.8-0.3
Time >=10cm from walls, locomotor time 20.00.10.40.3-0.10.2-0.20.1-0.4-0.2-0.20.2-0.20.20.10.2-0.1-0.10.1-0.6-0.4-0.0-0.00.1
Bouts of movement, locomotor time 20.40.61.40.8-0.80.9-0.90.8-0.7-0.8-0.80.8-0.81.0-0.70.6-0.6-0.4-0.6-0.6-1.2-0.6-0.60.6
Total resting periods, locomotor time 20.10.30.80.6-0.50.6-0.60.5-0.4-0.5-0.50.5-0.50.7-0.40.5-0.30.0-0.2-0.3-0.9-0.2-0.20.7
Rest time, locomotor task time 22.32.93.8-1.71.9-1.91.9-1.91.71.91.9-1.91.9-1.71.9-1.51.81.71.71.40.81.61.3-0.3
Distance moved, locomotor task time 21.11.41.81.2-1.21.3-1.31.3-1.3-1.2-1.21.2-1.21.1-1.20.9-1.3-1.3-1.3-1.1-0.8-1.2-0.90.0
Vertical activity count, locomotor time 20.20.31.6-0.3-0.10.1-0.10.10.10.00.0-0.00.0-0.50.0-0.6-0.5-0.7-0.8-0.1-0.4-1.2-0.9-1.3
Light reinforcement 10.10.10.4-0.40.4-0.40.4-0.30.30.20.2-0.20.2-0.40.2-0.60.30.40.10.6-0.5-0.20.0-0.6
Light reinforcement 20.50.81.9-1.01.0-1.01.0-1.01.01.01.0-1.01.0-1.40.9-1.10.80.61.00.60.50.10.4-1.0
Bone: marrow area1.02.27.1-0.91.3-1.31.3-1.31.31.31.3-1.31.3-0.71.5-0.01.91.52.00.32.72.11.91.4
Bone: maximum diameter0.20.31.50.5-0.50.6-0.60.5-0.5-0.5-0.50.5-0.50.1-0.50.5-0.6-1.0-0.3-1.2-0.2-0.7-0.7-0.2
Bone: maximum force3.25.69.12.8-2.62.7-2.72.6-2.5-2.6-2.62.6-2.62.7-2.73.0-2.1-2.2-1.5-2.9-0.7-0.9-1.02.0
Bone: maximum moment2.95.18.42.7-2.52.6-2.62.5-2.4-2.4-2.42.4-2.42.5-2.52.9-2.0-2.1-1.5-2.8-0.7-0.8-0.91.9
Mean time between licks in bursts0.10.30.90.4-0.60.6-0.60.5-0.5-0.7-0.70.7-0.70.6-0.60.4-0.6-0.8-1.0-0.2-0.0-0.6-0.70.0
Mean num. licks in bursts0.20.41.1-0.50.5-0.70.7-0.60.50.70.7-0.70.7-0.20.6-0.40.81.00.40.7-0.10.60.60.0
Cd content in liver1.11.21.8-1.21.2-1.21.2-1.21.21.21.2-1.21.2-1.31.1-1.21.11.31.30.90.40.60.6-0.7
Co content in liver1.31.63.6-1.61.4-1.31.3-1.41.21.21.2-1.21.2-1.51.4-1.90.81.10.31.6-0.6-0.10.1-1.6
Cu content in liver0.10.10.80.1-0.00.1-0.10.10.20.20.2-0.20.20.3-0.10.20.10.50.40.70.10.80.70.9
Fe content in liver0.20.31.00.3-0.60.5-0.50.4-0.4-0.4-0.40.4-0.40.1-0.50.2-0.6-1.0-0.7-0.8-0.3-0.7-0.8-0.5
K content in liver0.50.51.40.8-0.70.7-0.70.7-0.6-0.7-0.70.7-0.71.0-0.71.1-0.4-0.4-0.3-0.60.10.20.31.2
Mg content in liver0.50.51.1-0.50.6-0.60.6-0.60.70.60.6-0.60.6-0.20.6-0.20.80.90.70.71.01.01.10.6
Mn content in liver3.43.84.92.1-2.22.1-2.12.2-2.1-2.1-2.12.1-2.11.7-2.21.8-2.1-2.2-1.8-2.0-1.1-1.6-1.70.4
Na content in liver0.70.71.90.5-0.70.7-0.70.7-0.7-0.7-0.70.7-0.70.2-0.70.2-1.0-1.3-1.0-1.0-1.4-1.2-1.1-0.7
Rb content in liver2.02.34.2-1.51.5-1.51.5-1.61.61.71.7-1.71.7-1.11.5-1.31.82.11.51.80.91.51.40.1
Se content in liver0.10.10.3-0.40.2-0.20.2-0.30.40.40.4-0.40.4-0.50.2-0.40.40.30.50.10.30.10.0-0.3
Sr content in liver2.92.53.71.4-1.61.6-1.61.6-1.7-1.7-1.71.7-1.71.1-1.61.0-1.8-1.8-1.8-1.6-1.9-1.8-1.6-0.4
Zn content in liver0.20.20.60.6-0.50.6-0.60.5-0.5-0.5-0.50.5-0.50.8-0.50.6-0.4-0.1-0.4-0.1-0.5-0.00.10.7
Bone: minimum diameter1.12.05.4-0.61.2-0.90.9-1.01.21.21.2-1.21.2-0.21.10.21.81.82.00.72.12.32.11.8
Time in familiar zone, hab. session 10.40.41.5-0.40.5-0.40.4-0.50.50.50.5-0.50.5-0.30.3-0.10.50.60.80.91.20.80.90.5
Time in novel zone, hab. session 10.20.21.0-0.60.4-0.50.5-0.50.40.40.4-0.40.4-0.60.6-0.70.30.1-0.20.0-0.5-0.3-0.4-1.0
Total zone transitions, hab. session 10.60.81.41.1-1.01.1-1.11.1-1.0-0.9-0.90.9-0.91.2-1.11.1-0.9-0.6-0.6-0.5-0.3-0.2-0.21.1
Total locomotion distance, hab. session 10.40.61.5-0.40.7-0.70.7-0.70.50.60.6-0.60.6-0.30.7-0.00.70.71.00.61.21.21.20.8
Locomotion velocity, hab. session 10.10.20.90.10.2-0.20.2-0.10.10.10.1-0.10.10.20.20.40.30.30.50.20.60.80.80.9
Time in familiar zone, hab. session 20.10.10.3-0.30.0-0.00.0-0.00.3-0.0-0.00.0-0.0-0.20.0-0.3-0.2-0.4-0.50.3-0.1-0.4-0.3-0.5
Time in novel zone, hab. session 20.10.10.70.4-0.20.2-0.20.2-0.4-0.2-0.20.2-0.20.6-0.20.50.10.50.3-0.30.10.40.40.8
Total zone transitions, hab. session 21.51.96.71.8-1.31.4-1.41.3-1.4-1.3-1.31.3-1.32.2-1.32.2-0.4-0.3-0.4-1.10.80.60.72.6
Total locomotion distance, hab. session 20.50.73.70.30.2-0.20.2-0.2-0.00.00.0-0.00.00.80.20.90.70.60.70.11.61.41.61.9
Locomotion velocity, hab. session 20.60.83.30.20.4-0.30.3-0.30.20.30.3-0.30.30.50.40.80.90.71.00.11.81.61.71.8
Novel to familiar place preference ratio0.91.01.51.2-1.01.1-1.11.1-1.2-1.2-1.21.2-1.21.0-1.11.1-1.0-0.7-0.5-1.0-0.4-0.6-0.70.6
Novelty place preference0.40.40.70.8-0.60.7-0.70.7-0.8-0.7-0.70.7-0.70.7-0.70.7-0.6-0.3-0.2-0.6-0.3-0.3-0.30.4
Time in novel zone, NPP test0.30.30.50.7-0.50.6-0.60.6-0.7-0.6-0.60.6-0.60.6-0.60.6-0.4-0.2-0.1-0.5-0.2-0.3-0.30.4
Total zone transitions, NPP test2.13.05.12.1-1.91.9-1.91.9-2.0-1.9-1.91.9-1.92.3-1.82.3-1.4-1.3-1.3-1.9-0.5-0.5-0.51.7
Total locomotion distance, NPP test0.20.31.80.5-0.20.2-0.20.2-0.3-0.3-0.30.3-0.30.7-0.10.90.10.20.2-0.20.70.80.81.4
Locomotion velocity, NPP test0.20.31.80.6-0.30.3-0.30.3-0.4-0.3-0.30.3-0.30.8-0.30.9-0.00.20.2-0.30.50.70.71.3
Intraocular pressure1.01.53.7-1.51.3-1.31.3-1.31.11.21.2-1.21.2-1.91.5-1.90.80.60.80.7-0.5-0.3-0.4-1.9
Delta distance traveled before/after self-admin0.20.20.6-0.50.3-0.30.3-0.20.40.40.4-0.40.4-0.40.3-0.70.10.5-0.20.8-0.7-0.3-0.3-0.7
Delta ambulatory time before/after self-admin0.10.10.5-0.30.1-0.10.1-0.00.20.20.2-0.20.2-0.20.1-0.4-0.10.2-0.40.6-0.7-0.5-0.4-0.6
Parametrial fat weight3.58.311.5-2.83.1-3.23.2-3.23.02.82.8-2.82.8-2.63.4-2.23.23.13.42.52.92.82.9-0.1
Pavlov. Cond. lever latency0.30.30.8-0.70.6-0.60.6-0.50.60.60.6-0.60.6-0.80.6-0.90.40.40.20.8-0.4-0.0-0.1-0.7
Pavlov. Cond. magazine entry latency0.30.42.10.9-0.50.4-0.40.4-0.6-0.6-0.60.6-0.61.0-0.41.1-0.20.00.2-0.50.50.50.71.4
Pavlov. Cond. change in total contacts0.10.10.70.5-0.20.3-0.30.3-0.3-0.3-0.30.3-0.30.5-0.30.6-0.3-0.10.3-0.30.20.30.40.8
Pavlov. Cond. index score0.20.30.50.7-0.50.5-0.50.5-0.5-0.6-0.60.6-0.60.6-0.50.6-0.5-0.4-0.2-0.7-0.1-0.20.00.4
Pavlov. Cond. latency score0.10.20.40.6-0.30.3-0.30.3-0.4-0.5-0.50.5-0.50.6-0.30.7-0.3-0.2-0.0-0.60.30.10.30.6
Pavlov. Cond. lever contacts0.10.20.60.5-0.30.4-0.40.3-0.3-0.4-0.40.4-0.40.6-0.30.7-0.2-0.10.0-0.50.60.30.40.8
Pavlov. Cond. magazine entry number0.30.40.6-0.70.6-0.60.6-0.60.60.70.7-0.70.7-0.60.6-0.50.80.50.40.70.70.50.4-0.1
Pavlov. Cond. intertrial magazine entries0.40.51.2-0.90.7-0.40.4-0.51.00.80.8-0.80.8-1.00.4-1.10.40.80.50.80.20.00.0-1.0
Pavlov. Cond. lever-magazine prob. diff.0.40.40.80.9-0.70.6-0.60.6-0.7-0.8-0.80.8-0.80.9-0.60.9-0.6-0.5-0.2-0.8-0.1-0.10.10.8
Pavlov. Cond. response bias0.20.30.40.6-0.50.6-0.60.5-0.5-0.6-0.60.6-0.60.5-0.50.5-0.7-0.5-0.3-0.6-0.3-0.4-0.30.2
Pavlov. Cond. lever latency0.70.91.5-0.91.0-1.01.0-1.01.01.01.0-1.01.0-0.61.0-0.81.01.20.71.20.80.90.90.0
Pavlov. Cond. magazine entry latency4.35.17.22.7-2.52.7-2.72.6-2.4-2.5-2.52.5-2.52.7-2.72.6-2.0-1.9-1.8-2.1-1.4-1.1-1.21.7
Pavlov. Cond. change in total contacts1.42.33.31.8-1.81.8-1.81.8-1.6-1.6-1.61.6-1.61.6-1.81.6-1.4-1.3-0.8-1.4-0.8-0.8-0.91.0
Pavlov. Cond. index score2.43.34.72.1-1.92.1-2.12.0-2.0-2.0-2.02.0-2.01.9-2.22.0-1.7-1.7-1.3-1.8-1.1-1.0-1.11.1
Pavlov. Cond. latency score2.12.84.02.0-1.82.0-2.01.9-1.8-1.8-1.81.8-1.81.7-2.01.9-1.6-1.6-1.1-1.7-0.9-0.9-1.01.1
Pavlov. Cond. lever contacts0.60.91.51.0-1.01.0-1.01.0-1.0-1.0-1.01.0-1.00.7-1.10.8-0.9-1.2-0.7-1.2-0.8-0.9-0.90.0
Pavlov. Cond. magazine entry number6.98.611.4-3.43.3-3.33.3-3.33.23.23.2-3.23.2-3.23.4-3.12.82.62.42.72.01.81.9-1.6
Pavlov. Cond. intertrial magazine entries0.91.31.9-1.41.3-1.31.3-1.31.31.31.3-1.31.3-1.41.4-1.31.11.01.11.00.80.60.7-0.8
Pavlov. Cond. lever-magazine prob. diff.3.03.95.52.3-2.22.3-2.32.2-2.2-2.2-2.22.2-2.22.1-2.42.2-1.9-1.8-1.4-1.9-1.2-1.2-1.21.2
Pavlov. Cond. response bias2.12.83.81.9-1.81.9-1.91.9-1.9-1.8-1.81.8-1.81.7-1.91.8-1.6-1.7-1.3-1.8-1.2-1.0-1.10.9
Time in closed arm before self-admin0.20.30.9-0.40.5-0.40.4-0.50.50.50.5-0.50.5-0.50.8-0.30.70.70.90.50.90.60.60.1
Time in closed arm after self-admin0.30.31.1-0.50.4-0.30.3-0.40.60.50.5-0.50.5-0.40.6-0.30.50.50.50.81.00.40.50.1
Time in open arm before self-admin0.20.20.8-0.50.6-0.70.7-0.60.40.40.4-0.40.4-0.10.2-0.40.40.5-0.10.90.40.50.70.0
Time in open arm after self-admin0.10.11.10.2-0.10.1-0.10.1-0.3-0.3-0.30.3-0.30.2-0.20.0-0.2-0.1-0.5-0.3-1.0-0.2-0.3-0.2
Bone: periosteal estimation0.10.20.90.20.00.1-0.10.00.10.00.0-0.00.00.10.00.60.2-0.20.5-0.90.90.50.40.8
Bone: periosteal perimeter0.10.20.80.6-0.30.5-0.50.4-0.4-0.4-0.40.4-0.40.5-0.40.9-0.2-0.40.1-0.90.50.20.10.8
Bone: post-yield work1.72.514.91.7-0.80.9-0.90.9-0.8-0.8-0.80.8-0.82.0-0.92.60.20.41.2-1.02.42.12.13.9
Progressive ratio test 1 active lever presses0.20.20.6-0.50.8-0.30.3-0.40.60.50.5-0.50.5-0.60.2-0.40.70.50.70.20.50.40.5-0.3
Progressive ratio test 1 breakpoint0.20.20.5-0.40.7-0.30.3-0.40.50.40.4-0.40.4-0.60.1-0.40.60.40.60.10.40.30.5-0.3
Progressive ratio test 1 inactive lever presses0.10.10.2-0.30.4-0.30.3-0.20.30.20.2-0.20.2-0.40.1-0.40.30.40.30.3-0.20.10.0-0.3
Progressive ratio test 2 active lever presses2.12.43.6-1.71.9-1.51.5-1.61.81.51.5-1.51.5-1.91.4-1.61.81.61.91.31.41.11.3-0.9
Progressive ratio test 2 breakpoint2.02.33.7-1.71.9-1.51.5-1.61.71.51.5-1.51.5-1.91.3-1.61.71.51.81.31.41.11.2-0.9
Progressive ratio test 2 inactive lever presses5.89.412.1-3.33.3-3.23.2-3.23.33.23.2-3.23.2-3.43.1-3.13.43.43.53.02.42.52.3-1.3
Incentive Sensitization - Responses0.10.10.90.10.10.1-0.10.00.1-0.1-0.10.1-0.10.0-0.10.30.30.20.5-0.11.00.50.60.5
Incentive Sensitization - Breakpoint0.10.21.1-0.10.4-0.10.1-0.20.30.10.1-0.10.1-0.20.10.00.40.40.70.11.00.60.70.3
Sum of active levers in priming session hrs 5-62.42.37.20.7-1.21.2-1.21.2-1.0-1.0-1.01.0-1.0-0.1-1.5-0.0-2.0-2.2-1.5-1.4-1.8-2.7-2.6-1.8
Progressive ratio0.91.55.91.6-1.10.9-0.91.0-1.2-1.0-1.01.0-1.01.9-0.92.1-0.3-0.40.0-1.30.91.10.92.4
Food seeking constrained by brief footshock0.10.10.20.2-0.40.3-0.30.4-0.2-0.2-0.20.2-0.20.3-0.40.2-0.4-0.4-0.30.00.3-0.3-0.20.0
Seeking ratio, punishment vs. effort1.11.63.9-1.81.3-1.11.1-1.21.41.31.3-1.31.3-1.71.1-2.00.70.80.31.8-0.0-0.3-0.2-1.9
Retroperitoneal fat weight9.239.247.7-6.86.8-6.86.8-6.96.76.86.8-6.86.8-6.46.8-5.96.76.36.25.75.24.95.0-2.2
Reaction time number correct0.30.51.60.4-0.50.6-0.60.5-0.8-0.5-0.50.5-0.50.1-0.60.2-0.8-1.3-1.0-0.7-0.8-1.1-0.9-0.8
Reaction time mean minus median1.74.25.92.4-2.32.3-2.32.3-2.2-2.2-2.22.2-2.22.1-2.12.2-2.2-2.3-1.6-2.3-1.1-1.4-1.61.1
Reaction time mean minus median AUC0.92.33.71.6-1.61.7-1.71.6-1.6-1.6-1.61.6-1.61.3-1.51.3-1.7-1.9-1.4-1.7-1.1-1.3-1.60.3
Reaction time num false alarms0.20.31.2-0.70.7-0.60.6-0.50.80.40.4-0.40.4-0.50.4-0.60.40.60.21.10.50.30.4-0.1
Reaction time num false alarms AUC0.00.00.2-0.1-0.10.1-0.10.10.1-0.1-0.10.1-0.10.1-0.2-0.0-0.2-0.1-0.40.50.2-0.00.10.2
Reaction time trials correct on left0.30.51.60.4-0.50.6-0.60.5-0.8-0.5-0.50.5-0.50.1-0.60.2-0.8-1.3-1.0-0.7-0.8-1.1-0.9-0.8
Reaction time trials on left0.30.62.00.5-0.60.7-0.70.6-0.9-0.6-0.60.6-0.60.2-0.70.3-1.0-1.4-1.1-0.8-0.8-1.2-1.0-0.8
Reaction time mean0.00.10.10.3-0.20.2-0.20.2-0.2-0.4-0.40.4-0.40.20.10.1-0.3-0.20.1-0.3-0.2-0.2-0.30.2
Reaction time mean AUC0.00.00.10.3-0.10.1-0.10.2-0.1-0.3-0.30.3-0.30.20.10.2-0.2-0.00.2-0.1-0.1-0.0-0.10.4
Median of all reaction times0.10.10.4-0.30.4-0.50.5-0.40.40.20.2-0.20.2-0.20.6-0.30.40.50.60.30.20.30.30.1
Reaction time omissions1.72.53.71.8-1.81.9-1.91.8-1.7-1.6-1.61.6-1.61.7-1.61.6-1.7-1.8-1.4-1.5-1.0-0.9-1.20.7
Reaction time false alarm rate0.20.30.9-0.60.5-0.50.5-0.40.80.40.4-0.40.4-0.30.4-0.40.50.70.40.90.70.70.60.4
Reaction time premature initiation rate2.43.35.21.8-2.01.8-1.81.9-1.9-1.9-1.91.9-1.91.9-1.81.7-1.9-2.1-2.3-1.8-1.4-1.5-1.60.6
Reaction time premature initiations3.15.69.22.2-2.52.3-2.32.4-2.6-2.4-2.42.4-2.42.1-2.41.8-2.6-3.0-3.0-2.2-2.3-2.3-2.30.1
Std. dev. reaction times0.71.21.71.3-1.31.2-1.21.2-1.3-1.2-1.21.2-1.21.1-0.91.1-1.2-1.2-0.8-1.2-0.6-0.9-1.10.5
Reaction time trials completed0.30.62.00.5-0.60.7-0.70.6-0.9-0.6-0.60.6-0.60.2-0.70.3-1.0-1.4-1.1-0.8-0.8-1.2-1.0-0.8
Reaction time trials AUC0.20.41.40.3-0.40.5-0.50.5-0.7-0.5-0.50.5-0.50.1-0.50.2-0.8-1.2-0.9-0.6-0.6-1.0-0.8-0.7
Run reversals in cocaine runway, females0.70.73.20.8-0.50.6-0.60.5-0.6-0.6-0.60.6-0.61.2-0.41.3-0.1-0.1-0.00.11.21.01.11.8
Run reversals in cocaine runway, males0.60.63.1-0.90.6-0.60.6-0.60.60.60.6-0.60.6-1.30.5-1.2-0.1-0.3-0.20.2-0.6-0.8-0.7-1.8
Latency to leave start box in cocaine runway0.30.41.40.00.2-0.00.0-0.10.40.40.4-0.40.40.20.10.40.50.70.80.41.21.11.21.1
Latency to leave start box in cocaine runway, F0.20.21.10.10.20.0-0.0-0.10.10.20.2-0.20.20.30.00.30.40.70.60.30.41.01.00.9
Latency to leave start box in cocaine runway, M0.10.11.10.2-0.30.4-0.40.30.10.00.0-0.00.00.1-0.20.5-0.1-0.30.1-0.21.10.10.20.5
Std. dev. time between licks in bursts0.00.00.2-0.30.2-0.10.1-0.20.20.10.1-0.10.1-0.20.2-0.3-0.0-0.3-0.50.20.2-0.2-0.2-0.4
Total sessions with >9 infusions0.20.31.40.20.10.2-0.20.10.0-0.0-0.00.0-0.00.3-0.20.60.50.40.6-0.31.21.01.00.9
Short access day 1 total inactive lever presses2.02.73.6-1.71.6-1.71.7-1.61.81.71.7-1.71.7-1.61.6-1.41.71.71.71.91.61.61.4-0.4
Short access day 10 total inactive lever presses0.30.72.9-0.90.8-0.80.8-0.70.90.90.9-0.90.9-0.70.7-0.80.70.90.71.70.50.70.6-0.2
Short access day 1 total infusions1.72.24.7-1.21.5-1.31.3-1.41.51.41.4-1.41.4-1.01.2-0.71.81.71.91.32.22.12.00.5
Short access day 10 total infusions1.11.45.8-0.20.8-0.30.3-0.50.70.70.7-0.70.7-0.00.20.41.41.41.70.62.42.22.31.5
Short access total infusions0.81.05.0-0.40.8-0.50.5-0.60.70.70.7-0.70.7-0.30.30.21.21.01.30.52.21.71.81.0
Short access day 1 locomotion1.62.03.4-1.31.5-1.31.3-1.31.51.41.4-1.41.4-1.21.0-1.01.61.61.71.71.81.71.60.0
Short access day 10 total locomotion0.81.53.0-0.91.3-1.21.2-1.11.11.11.1-1.11.1-0.90.9-0.61.41.41.71.01.61.71.70.4
Short access total locomotion1.51.93.5-1.11.4-1.31.3-1.31.41.31.3-1.31.3-1.11.0-0.81.61.61.81.21.91.81.80.3
One hour access (0.3 mA shock)6.67.610.0-3.03.2-2.92.9-2.93.02.92.9-2.92.9-3.12.8-2.73.02.92.92.52.22.12.2-1.3
Compulsive drug intake1.92.24.51.3-1.41.4-1.41.4-1.5-1.5-1.51.5-1.51.5-1.31.0-1.6-1.6-2.1-1.3-2.1-1.7-1.6-0.0
One hour access (shock baseline)5.78.711.5-3.13.3-3.03.0-3.13.23.13.1-3.13.1-3.32.9-2.83.23.13.42.82.62.42.4-1.2
Social response proportion0.70.71.20.9-1.11.0-1.01.0-0.9-0.9-0.90.9-0.90.8-0.80.8-0.9-0.8-0.7-0.9-0.7-0.8-0.90.2
Social responses0.30.30.80.4-0.50.5-0.50.6-0.5-0.5-0.50.5-0.50.3-0.60.2-0.6-0.7-0.7-0.6-0.8-0.8-0.9-0.5
Social time0.30.51.00.5-0.60.6-0.60.6-0.9-0.5-0.50.5-0.50.4-0.60.3-0.7-1.0-1.0-0.8-0.9-0.9-0.9-0.5
Soleus weight4.011.915.3-3.83.8-3.93.9-3.93.73.83.8-3.83.8-3.73.9-3.43.53.43.32.92.32.52.6-1.5
Bone: stiffness2.33.86.32.4-2.12.2-2.22.1-2.1-2.2-2.22.2-2.22.3-2.12.5-1.6-1.6-1.1-2.2-0.8-0.7-0.71.7
Tibialis anterior weight10.435.348.26.1-6.56.4-6.46.3-6.4-6.3-6.36.3-6.35.2-6.45.3-6.5-6.9-6.1-6.5-4.7-5.1-5.10.8
Time to tail flick, vehicle, before self-admin0.20.20.70.6-0.30.4-0.40.3-0.5-0.5-0.50.5-0.50.6-0.30.8-0.1-0.1-0.0-0.10.80.20.30.8
Time to tail flick, vehicle, after self-admin0.60.84.51.1-0.60.5-0.50.6-0.8-0.7-0.70.7-0.71.4-0.51.6-0.0-0.20.0-0.81.01.10.92.1
Time to tail flick, test, before self-admin2.62.75.2-1.31.5-1.71.7-1.51.51.41.4-1.41.4-0.81.4-0.61.92.11.91.92.32.32.31.0
Time to tail flick, test, after self-admin0.10.10.30.1-0.20.1-0.10.1-0.3-0.2-0.20.2-0.2-0.1-0.00.0-0.2-0.2-0.2-0.1-0.2-0.6-0.5-0.4
Delta time to tail flick, vehicle, before/after SA0.40.31.40.7-0.60.5-0.50.5-0.6-0.5-0.50.5-0.50.9-0.51.0-0.3-0.3-0.3-0.7-0.00.40.21.2
Delta time to tail flick, test, before/after SA3.03.18.61.0-1.41.4-1.41.3-1.5-1.4-1.41.4-1.40.4-1.20.1-2.0-2.2-2.1-1.9-2.7-2.9-2.9-1.9
Tibia length1.23.35.81.6-1.71.9-1.91.9-1.8-1.8-1.81.8-1.80.9-1.91.1-2.1-2.3-1.5-2.4-1.8-2.1-2.2-0.6
Ambulatory time before self-admin0.30.50.80.9-0.80.8-0.80.7-0.7-0.8-0.80.8-0.80.8-0.70.9-0.5-0.3-0.0-0.8-0.2-0.1-0.20.8
Ambulatory time after self-admin0.20.31.5-0.30.3-0.30.3-0.40.40.40.4-0.40.4-0.20.5-0.20.51.20.80.8-0.20.50.50.3
Bone: tissue strength0.00.00.10.1-0.10.1-0.10.1-0.0-0.1-0.10.1-0.10.1-0.10.1-0.00.10.1-0.10.30.10.10.2
Total heroin consumption5.26.17.72.7-2.72.6-2.62.6-2.7-2.7-2.72.7-2.72.6-2.82.4-2.6-2.6-2.3-2.3-2.1-2.0-1.81.1
Bone: trabecular number0.71.22.71.4-1.01.3-1.31.2-1.1-1.1-1.11.1-1.11.5-1.31.7-0.5-0.4-0.2-1.2-0.20.20.01.5
Bone: trabecular spacing0.40.61.1-0.90.8-0.90.9-0.90.70.80.8-0.80.8-0.70.8-0.90.70.60.41.10.40.40.5-0.3
Bone: trabecular thickness0.40.51.3-0.40.6-0.40.4-0.50.60.70.7-0.70.7-0.20.5-0.10.81.01.00.70.71.11.00.7
Bone: trabecular tissue density3.95.78.1-2.82.5-2.72.7-2.72.72.62.6-2.62.6-2.82.6-2.82.22.22.12.41.21.31.2-1.6
Water consumed over 24 hours0.91.22.61.1-1.21.2-1.21.2-1.3-1.2-1.21.2-1.21.2-1.30.8-1.0-0.8-1.3-0.8-1.6-1.0-1.00.1
Number of responses in last shaping day0.00.00.4-0.20.3-0.00.0-0.10.10.00.0-0.00.0-0.10.1-0.30.1-0.0-0.20.1-0.6-0.3-0.2-0.4