Hub : Genes

Nudt2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Nudt2	0.07	0.04	5.4e-05	0.05	0.03	0.04	0.04	2.0e-05	1.9e-03	9.2e-05	5.8e-05
2	Liver	gene expression	Nudt2	0.03	0.03	9.8e-03	0.02	0.01	0.01	0.01	6.3e-03	1.3e-02	8.6e-03	1.3e-02
3	PL	gene expression	Nudt2	0.04	0.03	1.0e-03	0.03	0.02	0.03	0.03	4.0e-04	2.4e-03	5.2e-04	6.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	1.0	1.9	2.2	1.1	-1.4	-1.5
Area under the delay curve	0.7	1.0	1.5	-0.7	1.0	1.2
BMI with tail	1.3	4.6	5.0	2.1	-2.1	-2.2
BMI without tail	1.0	5.4	6.2	2.5	-2.2	-2.3
Body weight	2.6	11.2	14.6	3.8	-3.1	-3.1
Weight adjusted by age	0.0	0.0	0.1	0.2	0.1	0.2
Bone surface	0.6	1.1	1.1	1.1	-1.0	-1.1
Bone volume	0.5	1.0	1.1	0.9	-1.0	-1.0
Breakpoint value in progressive ratio session	1.3	2.3	3.5	-0.5	1.8	1.9
Number of licking bursts	2.6	7.8	8.3	2.7	-2.9	-2.8
Context. condit. distance diff. score	0.1	0.1	0.1	-0.3	0.3	0.3
Locomotion velocity, session 1	0.7	0.7	1.3	1.1	0.7	0.7
Locomotion distance, session 1	0.2	0.2	0.5	0.7	0.3	0.3
Locomotion velocity, session 2	1.9	2.3	2.6	1.3	-1.6	-1.6
Locomotion distance, session 2	1.5	2.1	3.4	1.8	-1.2	-1.2
Locomotion velocity, session 3	0.1	0.1	0.3	0.5	0.1	0.2
Locomotion distance, session 3	1.3	1.5	2.4	1.6	-1.0	-1.0
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	0.1	0.1	0.0
Stereotopy head waving duration, day 3	0.0	0.0	0.1	-0.2	0.0	-0.0
Locomotion velocity, session 7	0.1	0.1	0.1	-0.3	0.2	0.2
Locomotion distance, session 7	0.1	0.1	0.2	0.5	-0.2	-0.3
Stereotopy head waving bouts, day 7	1.5	1.7	2.0	1.4	-1.2	-1.2
Stereotopy head waving duration, day 7	0.9	1.2	1.2	1.1	-1.1	-1.0
Locomotion velocity, session 8	0.2	0.2	0.3	0.6	0.4	0.4
Locomotion distance, session 8	0.1	0.2	0.5	0.7	0.0	0.0
Degree of sensitization distance	0.7	0.7	1.1	-1.1	0.8	0.7
Degree of sensitization stereotypy	1.5	1.7	1.8	1.3	-1.3	-1.3
Conditioned locomotion	0.1	0.1	0.1	0.1	0.2	0.4
Cocaine response after cond. corrected	1.3	2.0	2.7	-0.9	1.6	1.6
Cocaine response after cond. not corrected	1.2	1.7	2.3	-0.8	1.5	1.5
Cocaine response before conditioning	0.8	1.0	1.2	0.9	-1.1	-1.0
Saline control response	1.1	1.5	2.2	1.5	-1.1	-1.1
Bone: connectivity density	0.4	0.7	0.9	0.6	-0.9	-1.0
Bone: cortical apparent density	0.1	0.1	0.2	-0.0	-0.5	-0.4
Bone: cortical area	3.0	4.8	6.1	1.7	-2.5	-2.4
Bone: cortical porosity	0.1	0.1	0.3	-0.5	0.3	0.2
Bone: cortical porosity	0.0	0.0	0.0	0.0	-0.1	-0.2
Bone: cortical thickness	1.3	2.2	3.2	0.7	-1.8	-1.7
Bone: cortical thickness	0.2	0.2	0.5	-0.7	-0.1	-0.1
Bone: cortical tissue density	0.0	0.1	0.1	-0.1	-0.4	-0.3
Condit. Reinf. active minus inactive responses	0.5	0.6	0.6	0.7	-0.8	-0.8
Condit. Reinf. active-inactive response ratio	0.5	0.6	0.7	-0.8	0.7	0.7
Condit. Reinf. active responses	2.8	3.5	3.8	1.8	-1.9	-1.9
Condit. Reinf. inactive responses	3.2	4.1	4.7	1.8	-2.2	-2.1
Incentive salience index mean	4.0	5.1	6.0	2.4	-2.2	-2.1
Condit. Reinf. lever presses	8.7	13.0	17.4	4.2	-3.3	-3.2
Condit. Reinf. active minus inactive responses	0.5	0.8	0.9	0.9	-0.9	-0.9
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.1	-0.1	-0.2
Condit. Reinf. active responses	2.1	3.0	3.0	1.7	-1.7	-1.7
Condit. Reinf. inactive responses	3.3	5.0	5.9	1.9	-2.4	-2.3
Condit. Reinf. lever presses	3.3	4.7	6.0	1.6	-2.4	-2.4
Condit. Reinf. lever reinforcers received	2.6	3.6	3.7	1.9	-1.9	-1.9
Conditioned reinforcement - actives	0.2	0.6	0.8	0.6	-0.9	-0.9
Conditioned reinforcement - inactives	0.0	0.1	0.2	0.3	-0.3	-0.5
Conditioned locomotion	0.1	0.1	0.1	0.2	-0.3	-0.4
Patch foraging indifference point 0 sec	0.1	0.4	0.6	0.8	0.6	0.4
Patch foraging indifference point AUC	3.2	7.7	9.4	3.1	-2.7	-2.5
Delay disc. indifference point, 0s delay	1.0	1.1	1.4	-0.8	1.1	1.2
Delay disc. indifference point, 16s delay	1.2	1.8	2.5	-0.6	1.6	1.6
Delay disc. indifference point, 2s delay	0.3	0.3	0.6	0.2	-0.8	-0.6
Delay disc. indifference point, 24s delay	0.2	0.4	0.5	-0.5	0.7	0.6
Delay disc. indifference point, 4s delay	0.2	0.2	0.2	-0.5	0.4	0.5
Delay disc. indifference point, 8s delay	0.0	0.1	0.1	-0.1	0.1	0.4
Indifference point function ln k	0.9	2.7	3.1	-1.8	1.6	1.6
Indifference point function log k	0.9	2.7	3.1	-1.8	1.6	1.6
Patch foraging total patch changes 0 sec	0.2	0.5	1.4	1.2	0.1	-0.1
Patch foraging total patch changes 12 sec	1.4	1.8	2.4	1.5	-1.2	-1.3
Patch foraging total patch changes 18 sec	0.2	0.4	0.9	0.9	-0.5	-0.4
Patch foraging total patch changes 24 sec	0.6	2.0	3.2	1.8	-1.2	-1.1
Patch foraging total patch changes 6 sec	1.3	2.2	4.7	2.2	-0.8	-1.1
Patch foraging time to switch 0 sec	0.6	2.4	3.7	-1.9	1.3	1.4
Patch foraging water rate 0 sec	0.4	1.4	2.7	1.6	-0.7	-0.9
Patch foraging water rate 12 sec	0.0	0.0	0.0	0.2	0.0	-0.2
Patch foraging water rate 18 sec	0.4	0.9	1.3	0.6	-1.0	-1.1
Patch foraging water rate 24 sec	0.1	0.1	0.1	-0.3	-0.4	-0.4
Patch foraging water rate 6 sec	1.5	2.2	2.3	1.5	-1.5	-1.5
Seeking ratio, delayed vs. immediate footshock	2.6	3.8	4.5	2.1	-1.9	-1.8
Distance traveled before self-admin	2.9	6.3	7.6	2.8	-2.3	-2.4
Distance traveled after self-admin	3.1	5.4	6.4	1.8	-2.5	-2.5
Extensor digitorum longus weight	5.1	20.4	22.2	4.7	-4.4	-4.4
Bone: elastic displacement	5.9	7.5	9.7	-3.1	2.5	2.6
Bone: elastic work	1.6	2.0	4.6	-2.2	0.8	0.9
Bone: endosteal estimation	0.9	2.2	3.1	1.7	-1.4	-1.3
Bone: endosteal perimeter	0.7	1.8	2.7	1.6	-1.2	-1.1
Epididymis fat weight	0.1	0.7	0.8	0.8	-0.9	-0.9
Delta time in closed arm before/after self-admin	0.4	0.4	0.5	0.3	-0.7	-0.7
Delta time in open arm before/after self-admin	0.1	0.2	0.3	-0.2	0.5	0.5
Diff in mean of infusions in LGA sessions	0.1	0.2	0.2	-0.5	-0.4	-0.4
Delay discount exponential model param	0.7	0.9	1.3	0.7	-1.0	-1.1
Extinction: sum of active levers before priming	1.6	2.4	2.7	-1.7	1.5	1.5
Active lever presses in extinction session 6	0.6	0.6	0.7	-0.7	0.8	0.8
Bone: final force	2.2	3.5	4.0	1.7	-1.9	-2.0
Bone: final moment	1.8	2.9	3.5	1.4	-1.8	-1.9
Food consumed during 24 hour testing period	0.5	1.1	1.7	1.3	-0.8	-0.9
Glucose	1.6	2.5	3.4	1.8	-1.5	-1.4
Heart weight	0.3	0.4	0.5	0.7	-0.7	-0.6
Delay discount hyperbolic model param	0.5	0.7	1.0	0.5	-0.9	-1.0
Intermittent access intake day 1-15 change	0.3	1.4	1.8	1.0	-1.2	-1.3
Intermittent access intake escalation	0.3	1.4	1.9	0.8	-1.3	-1.4
Intermittent access intake escalation 2	1.9	3.2	4.3	1.2	-2.0	-2.1
Intermitt. access day 1 inactive lever presses	0.1	0.7	1.6	1.3	-0.5	-0.6
Intermitt. access day 15 inactive lever presses	0.0	0.3	0.4	0.5	-0.4	-0.6
Intermitt. access escalation Index	0.1	0.2	0.3	0.6	-0.4	-0.5
Intermittent access day 1 total infusions	0.8	2.3	3.0	-1.1	1.7	1.6
Intermittent access day 15 total infusions	0.1	0.2	0.4	0.2	-0.5	-0.6
Intermittent access terminal intake (last 3 days)	0.6	1.0	1.2	0.8	-1.1	-1.1
Intermittent access total infusions	0.2	0.2	0.3	0.6	-0.4	-0.4
Intermittent access day 1 locomotion	1.4	2.6	3.3	-1.4	1.8	1.7
Intermittent access day 15 total locomotion	0.5	1.8	2.1	-1.2	1.5	1.4
Intermittent access total locomotion	0.9	1.1	1.7	-1.3	0.9	0.9
Intermittent access standard deviation	0.1	0.5	0.7	0.9	-0.6	-0.6
Left kidney weight	0.2	1.7	3.5	1.9	-1.0	-0.9
Right kidney weight	0.1	1.0	1.1	1.1	-0.9	-1.0
Cocaine induced anxiety	0.0	0.1	0.2	0.4	-0.3	-0.3
Post-drug Anxiety	1.2	1.3	2.2	1.5	-1.0	-0.9
Baseline Anxiety	0.3	0.6	0.7	0.8	-0.6	-0.8
Tail length	1.3	6.8	7.8	2.8	-2.5	-2.5
Length with tail	1.1	4.7	7.5	2.7	-1.9	-1.8
Length without tail	0.0	0.1	0.4	0.6	0.1	0.1
Times rat made contact with spout	0.7	0.8	0.9	0.8	-0.9	-0.9
Lifetime Intake	0.2	0.3	0.6	0.8	-0.3	-0.4
Liver weight, left	0.0	0.0	0.1	-0.1	0.2	0.2
Liver weight, right	0.2	0.3	0.7	-0.8	0.4	0.4
Locomotor activity	0.0	0.0	0.1	0.1	-0.2	-0.2
Locomotor testing distance	0.1	0.2	0.3	-0.1	0.4	0.5
Locomotor testing rearing	0.5	1.8	2.3	1.5	-1.3	-1.2
Locomotion in novel chamber	0.2	0.2	0.4	-0.6	0.4	0.4
Locomotion in novel chamber post-restriction	0.8	2.4	3.2	0.9	-1.8	-1.8
Fecal boli incidents, locomotor time 1	0.7	1.9	2.2	-1.5	1.3	1.3
Change in fecal boli incidents, locomotor task	0.4	0.4	0.9	0.9	-0.5	-0.3
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.5	0.1	-0.1
Bouts of movement, locomotor time 1	1.0	1.3	2.3	-1.5	0.9	0.9
Total resting periods, locomotor time 1	1.5	1.8	3.5	-1.9	1.0	0.9
Rest time, locomotor task time 1	0.7	1.1	3.2	-1.8	0.3	0.1
Distance moved, locomotor task time 1	0.6	1.8	4.0	2.0	-0.9	-0.8
Vertical activity count, locomotor time 1	0.2	1.2	3.3	1.8	-0.4	-0.3
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.1	0.3	0.2	-0.0
Bouts of movement, locomotor time 2	0.2	0.8	0.8	0.9	-0.9	-0.8
Total resting periods, locomotor time 2	0.1	0.4	0.5	0.5	-0.7	-0.6
Rest time, locomotor task time 2	0.3	0.6	1.7	-1.3	0.2	0.2
Distance moved, locomotor task time 2	0.4	0.6	0.6	0.8	-0.7	-0.7
Vertical activity count, locomotor time 2	0.2	0.6	1.4	1.2	-0.4	-0.4
Light reinforcement 1	0.3	1.4	3.8	1.9	-0.4	-0.5
Light reinforcement 2	0.2	0.5	1.3	1.1	0.3	0.4
Bone: marrow area	1.0	2.5	3.1	1.8	-1.5	-1.4
Bone: maximum diameter	2.5	5.1	5.9	2.0	-2.4	-2.3
Bone: maximum force	3.7	7.3	8.4	2.4	-2.8	-2.9
Bone: maximum moment	3.2	6.0	7.1	2.1	-2.6	-2.7
Mean time between licks in bursts	0.1	0.6	0.6	-0.8	0.7	0.7
Mean num. licks in bursts	1.3	3.5	3.6	-1.9	1.9	1.8
Cd content in liver	1.1	1.2	1.5	0.9	-1.1	-1.2
Co content in liver	0.6	0.7	1.0	-0.6	1.0	0.9
Cu content in liver	1.5	1.8	2.9	-1.7	1.1	1.1
Fe content in liver	0.8	0.9	1.4	-0.4	1.1	1.2
K content in liver	0.4	0.4	0.6	-0.4	0.8	0.7
Mg content in liver	1.2	1.3	1.5	-1.0	1.2	1.2
Mn content in liver	2.2	2.4	3.4	0.8	-1.8	-1.8
Na content in liver	0.9	1.1	1.7	-1.3	0.9	0.9
Rb content in liver	4.8	5.6	6.5	-2.1	2.4	2.6
Se content in liver	3.5	4.2	4.8	1.7	-2.2	-2.2
Sr content in liver	0.3	0.3	0.5	-0.2	-0.5	-0.7
Zn content in liver	0.0	0.0	0.0	-0.2	0.0	-0.1
Bone: minimum diameter	0.0	0.0	0.1	-0.4	-0.0	0.1
Time in familiar zone, hab. session 1	0.4	0.4	1.0	-1.0	-0.2	-0.3
Time in novel zone, hab. session 1	2.3	2.5	3.7	-0.8	1.8	1.9
Total zone transitions, hab. session 1	0.0	0.0	0.1	-0.2	0.2	0.2
Total locomotion distance, hab. session 1	0.4	0.5	0.8	0.1	-0.9	-0.9
Locomotion velocity, hab. session 1	1.5	2.1	2.6	1.0	-1.6	-1.6
Time in familiar zone, hab. session 2	0.5	0.6	1.6	-1.3	0.3	0.4
Time in novel zone, hab. session 2	1.2	1.3	1.8	-0.6	1.3	1.4
Total zone transitions, hab. session 2	0.3	0.4	1.0	1.0	-0.2	-0.2
Total locomotion distance, hab. session 2	0.6	0.8	1.1	1.0	-0.8	-0.8
Locomotion velocity, hab. session 2	0.8	1.1	1.4	1.2	-0.9	-0.9
Novel to familiar place preference ratio	3.1	4.0	4.6	-1.8	2.2	2.0
Novelty place preference	4.1	5.2	5.7	-2.1	2.4	2.3
Time in novel zone, NPP test	5.1	6.2	6.8	-2.3	2.6	2.5
Total zone transitions, NPP test	0.3	0.4	1.2	1.1	-0.3	-0.2
Total locomotion distance, NPP test	1.0	1.4	2.6	1.6	-1.0	-0.9
Locomotion velocity, NPP test	1.4	2.1	3.3	1.8	-1.3	-1.2
Intraocular pressure	1.9	3.1	4.2	2.1	-1.7	-1.5
Delta distance traveled before/after self-admin	0.1	0.1	0.1	0.1	-0.3	-0.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	-0.5	0.1	0.2
Parametrial fat weight	0.4	0.8	1.4	-0.4	1.2	1.0
Pavlov. Cond. lever latency	7.0	8.8	10.8	-3.3	2.9	2.7
Pavlov. Cond. magazine entry latency	0.3	0.4	0.4	0.7	-0.6	-0.6
Pavlov. Cond. change in total contacts	2.5	2.7	3.8	2.0	-1.5	-1.4
Pavlov. Cond. index score	3.2	4.0	4.6	2.1	-2.0	-1.9
Pavlov. Cond. latency score	2.9	3.7	4.3	2.1	-1.9	-1.8
Pavlov. Cond. lever contacts	6.5	7.8	9.4	3.1	-2.7	-2.6
Pavlov. Cond. magazine entry number	0.5	0.6	0.7	-0.8	0.8	0.8
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.4	0.5	-0.6	-0.5
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.0	4.2	2.1	-2.0	-1.9
Pavlov. Cond. response bias	3.6	4.5	5.3	2.3	-2.1	-2.0
Pavlov. Cond. lever latency	3.1	4.3	5.5	-1.5	2.3	2.3
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.5	0.0	-0.0
Pavlov. Cond. change in total contacts	0.7	1.7	2.5	0.4	-1.5	-1.6
Pavlov. Cond. index score	0.5	0.8	1.2	0.1	-1.0	-1.1
Pavlov. Cond. latency score	0.6	1.0	1.6	0.3	-1.2	-1.3
Pavlov. Cond. lever contacts	2.2	3.3	4.3	1.2	-2.0	-2.1
Pavlov. Cond. magazine entry number	0.5	0.6	1.0	-0.0	1.0	1.0
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	0.5	-0.4	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.8	1.2	0.1	-1.1	-1.1
Pavlov. Cond. response bias	1.4	1.9	2.7	0.6	-1.6	-1.6
Time in closed arm before self-admin	0.5	0.8	1.0	-0.7	1.0	1.0
Time in closed arm after self-admin	0.1	0.1	0.2	-0.5	0.2	0.1
Time in open arm before self-admin	0.6	0.7	1.2	1.1	-0.7	-0.7
Time in open arm after self-admin	0.6	0.6	1.1	1.0	-0.7	-0.6
Bone: periosteal estimation	1.8	4.2	4.8	1.9	-2.2	-2.0
Bone: periosteal perimeter	0.4	0.9	1.1	1.1	-0.9	-0.8
Bone: post-yield work	1.6	2.8	3.6	1.9	-1.5	-1.6
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.3	0.3	0.3
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.4	0.3	0.2
Progressive ratio test 1 inactive lever presses	0.4	0.9	2.2	1.5	-0.5	-0.6
Progressive ratio test 2 active lever presses	0.1	0.2	0.2	0.2	0.4	0.5
Progressive ratio test 2 breakpoint	0.1	0.2	0.3	0.2	0.5	0.5
Progressive ratio test 2 inactive lever presses	0.1	0.4	0.5	0.7	-0.6	-0.6
Incentive Sensitization - Responses	0.1	0.2	0.5	0.7	-0.2	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	0.6	-0.1	-0.1
Sum of active levers in priming session hrs 5-6	4.8	4.5	5.7	-1.5	2.3	2.4
Progressive ratio	0.1	0.3	0.5	-0.0	0.7	0.6
Food seeking constrained by brief footshock	7.0	8.7	15.0	3.9	-2.3	-2.4
Seeking ratio, punishment vs. effort	1.9	4.2	4.5	2.1	-2.0	-2.0
Retroperitoneal fat weight	0.4	2.0	2.4	-1.6	1.3	1.3
Reaction time number correct	0.0	0.1	0.1	0.3	0.3	0.2
Reaction time mean minus median	0.2	1.0	1.5	-0.3	-1.2	-1.2
Reaction time mean minus median AUC	0.3	1.8	2.8	0.4	-1.6	-1.7
Reaction time num false alarms	0.3	0.5	0.7	-0.0	-0.8	-0.9
Reaction time num false alarms AUC	0.5	1.1	1.4	0.6	-1.2	-1.2
Reaction time trials correct on left	0.0	0.1	0.1	0.3	0.3	0.2
Reaction time trials on left	0.0	0.1	0.2	0.2	0.4	0.3
Reaction time mean	0.6	1.4	3.1	-1.8	0.7	0.7
Reaction time mean AUC	0.6	1.4	3.4	-1.9	0.7	0.7
Median of all reaction times	2.0	3.1	4.6	-2.1	1.5	1.6
Reaction time omissions	2.0	3.2	3.9	-2.0	1.7	1.7
Reaction time false alarm rate	0.3	0.4	0.6	-0.1	-0.8	-0.7
Reaction time premature initiation rate	1.8	2.7	4.6	-2.2	1.4	1.3
Reaction time premature initiations	0.8	2.3	3.3	-1.8	1.4	1.3
Std. dev. reaction times	0.1	0.4	1.0	-1.0	-0.4	-0.4
Reaction time trials completed	0.0	0.1	0.2	0.2	0.4	0.3
Reaction time trials AUC	0.0	0.1	0.2	0.1	0.4	0.3
Run reversals in cocaine runway, females	0.1	0.1	0.2	-0.4	0.2	0.2
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.2	0.1	0.1
Latency to leave start box in cocaine runway	0.7	1.0	1.4	0.7	-1.2	-1.0
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	-0.3	0.4	0.6
Latency to leave start box in cocaine runway, M	4.0	3.9	4.4	1.8	-2.1	-2.0
Std. dev. time between licks in bursts	0.2	0.3	0.4	-0.7	0.5	0.5
Total sessions with >9 infusions	0.4	0.5	1.0	1.0	-0.5	-0.5
Short access day 1 total inactive lever presses	0.6	1.1	2.6	1.6	-0.5	-0.7
Short access day 10 total inactive lever presses	0.1	1.0	1.4	1.0	-0.9	-1.2
Short access day 1 total infusions	0.3	0.7	1.5	1.2	-0.5	-0.5
Short access day 10 total infusions	0.2	0.3	0.4	0.3	0.6	0.6
Short access total infusions	0.1	0.2	0.4	0.6	0.1	0.1
Short access day 1 locomotion	1.3	2.1	2.5	-1.2	1.6	1.6
Short access day 10 total locomotion	0.3	1.1	1.7	-1.3	1.0	0.8
Short access total locomotion	0.5	0.8	1.1	-0.7	1.0	1.0
One hour access (0.3 mA shock)	0.2	0.2	0.4	0.6	-0.3	-0.4
Compulsive drug intake	0.0	0.0	0.1	-0.1	-0.2	-0.2
One hour access (shock baseline)	0.1	0.1	0.3	0.6	0.2	0.2
Social response proportion	2.5	3.2	3.4	-1.8	1.8	1.7
Social responses	0.5	0.6	0.7	0.9	-0.8	-0.8
Social time	0.1	0.1	0.2	-0.1	0.5	0.5
Soleus weight	0.3	0.9	1.3	0.6	1.1	1.0
Bone: stiffness	5.0	9.1	10.3	2.8	-3.0	-3.2
Tibialis anterior weight	7.6	26.3	32.9	5.7	-4.9	-4.7
Time to tail flick, vehicle, before self-admin	1.3	1.6	2.2	-1.5	1.1	1.1
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.1	0.1	-0.3	-0.2
Time to tail flick, test, before self-admin	0.6	0.7	0.9	0.9	-0.8	-0.7
Time to tail flick, test, after self-admin	0.9	0.9	1.2	0.7	-1.1	-1.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	0.9	1.0	-0.7	-0.6
Delta time to tail flick, test, before/after SA	0.1	0.2	0.4	-0.6	0.2	0.2
Tibia length	0.0	0.1	0.4	0.6	-0.1	0.1
Ambulatory time before self-admin	1.5	4.5	5.8	2.4	-1.9	-2.0
Ambulatory time after self-admin	1.2	1.9	2.0	1.3	-1.4	-1.4
Bone: tissue strength	0.1	0.1	0.2	0.3	-0.3	-0.4
Total heroin consumption	1.0	1.1	1.4	-0.8	1.1	1.2
Bone: trabecular number	0.8	1.4	1.7	1.0	-1.2	-1.3
Bone: trabecular spacing	0.1	0.1	0.2	-0.0	-0.5	-0.3
Bone: trabecular thickness	0.2	0.2	0.5	-0.7	0.3	0.3
Bone: trabecular tissue density	3.4	6.0	6.4	2.4	-2.5	-2.4
Water consumed over 24 hours	0.9	1.7	1.8	1.3	-1.3	-1.3
Number of responses in last shaping day	0.5	0.7	1.0	0.2	1.0	1.0