Hub : Genes

Nudt2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Nudt2 0.07 0.04 5.4e-05 0.05 0.03 0.04 0.04 2.0e-05 1.9e-03 8.9e-05 6.1e-05
2 Liver gene expression Nudt2 0.03 0.03 9.8e-03 0.02 0.01 0.01 0.01 6.3e-03 1.3e-02 8.7e-03 1.3e-02
3 PL gene expression Nudt2 0.04 0.03 1.0e-03 0.03 0.02 0.03 0.03 4.0e-04 2.4e-03 5.2e-04 6.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density1.11.92.2-1.11.41.5
Area under the delay curve0.91.01.50.7-1.0-1.2
BMI with tail1.34.65.0-2.12.12.2
BMI without tail1.85.46.2-2.52.22.3
Body weight2.611.214.6-3.83.13.1
Weight adjusted by age0.00.00.1-0.2-0.1-0.2
Bone surface0.61.11.1-1.11.01.1
Bone volume0.51.01.1-0.91.01.0
Breakpoint value in progressive ratio session1.92.33.50.5-1.8-1.9
Number of licking bursts4.87.88.3-2.72.92.8
Context. condit. distance diff. score0.10.10.10.3-0.3-0.3
Locomotion velocity, session 10.70.71.3-1.1-0.7-0.7
Locomotion distance, session 10.20.20.5-0.7-0.3-0.3
Locomotion velocity, session 22.02.32.6-1.31.61.6
Locomotion distance, session 21.52.13.4-1.81.21.2
Locomotion velocity, session 30.10.10.3-0.5-0.1-0.2
Locomotion distance, session 31.41.52.4-1.61.01.0
Stereotopy head waving bouts, day 30.00.00.0-0.1-0.1-0.0
Stereotopy head waving duration, day 30.00.00.10.2-0.00.0
Locomotion velocity, session 70.10.10.10.3-0.2-0.2
Locomotion distance, session 70.10.10.2-0.50.20.3
Stereotopy head waving bouts, day 71.51.72.0-1.41.21.2
Stereotopy head waving duration, day 71.01.21.2-1.11.11.0
Locomotion velocity, session 80.20.20.3-0.6-0.4-0.4
Locomotion distance, session 80.10.20.5-0.7-0.0-0.0
Degree of sensitization distance0.70.71.11.1-0.8-0.7
Degree of sensitization stereotypy1.61.71.8-1.31.31.3
Conditioned locomotion0.10.10.1-0.1-0.2-0.4
Cocaine response after cond. corrected1.62.02.70.9-1.6-1.6
Cocaine response after cond. not corrected1.41.72.30.8-1.5-1.5
Cocaine response before conditioning0.81.01.2-0.91.11.0
Saline control response1.11.52.2-1.51.11.1
Bone: connectivity density0.40.70.9-0.60.91.0
Bone: cortical apparent density0.10.10.20.00.50.4
Bone: cortical area3.14.86.1-1.72.52.4
Bone: cortical porosity0.10.10.30.5-0.3-0.2
Bone: cortical porosity0.00.00.0-0.00.10.2
Bone: cortical thickness1.32.23.2-0.71.81.7
Bone: cortical thickness0.20.20.50.70.10.1
Bone: cortical tissue density0.10.10.10.10.40.3
Condit. Reinf. active minus inactive responses0.50.60.6-0.70.80.8
Condit. Reinf. active-inactive response ratio0.50.60.70.8-0.7-0.7
Condit. Reinf. active responses2.93.53.8-1.81.91.9
Condit. Reinf. inactive responses3.44.14.7-1.82.22.1
Incentive salience index mean4.15.16.0-2.42.22.1
Condit. Reinf. lever presses9.213.017.4-4.23.33.2
Condit. Reinf. active minus inactive responses0.60.80.9-0.90.90.9
Condit. Reinf. active-inactive response ratio0.00.00.0-0.10.10.2
Condit. Reinf. active responses2.13.03.0-1.71.71.7
Condit. Reinf. inactive responses3.85.05.9-1.92.42.3
Condit. Reinf. lever presses3.44.76.0-1.62.42.4
Condit. Reinf. lever reinforcers received2.63.63.7-1.91.91.9
Conditioned reinforcement - actives0.40.60.8-0.60.90.9
Conditioned reinforcement - inactives0.10.10.2-0.30.30.5
Conditioned locomotion0.10.10.1-0.20.30.4
Patch foraging indifference point 0 sec0.20.40.6-0.8-0.6-0.4
Patch foraging indifference point AUC5.37.79.4-3.12.72.5
Delay disc. indifference point, 0s delay1.01.11.40.8-1.1-1.2
Delay disc. indifference point, 16s delay1.61.82.50.6-1.6-1.6
Delay disc. indifference point, 2s delay0.30.30.6-0.20.80.6
Delay disc. indifference point, 24s delay0.30.40.50.5-0.7-0.6
Delay disc. indifference point, 4s delay0.20.20.20.5-0.4-0.5
Delay disc. indifference point, 8s delay0.00.10.10.1-0.1-0.4
Indifference point function ln k1.62.73.11.8-1.6-1.6
Indifference point function log k1.62.73.11.8-1.6-1.6
Patch foraging total patch changes 0 sec0.20.51.4-1.2-0.10.1
Patch foraging total patch changes 12 sec1.41.82.4-1.51.21.3
Patch foraging total patch changes 18 sec0.30.40.9-0.90.50.4
Patch foraging total patch changes 24 sec1.22.03.2-1.81.21.1
Patch foraging total patch changes 6 sec1.52.24.7-2.20.81.1
Patch foraging time to switch 0 sec1.22.43.71.9-1.3-1.4
Patch foraging water rate 0 sec0.61.42.7-1.60.70.9
Patch foraging water rate 12 sec0.00.00.0-0.2-0.00.2
Patch foraging water rate 18 sec0.60.91.3-0.61.01.1
Patch foraging water rate 24 sec0.10.10.10.30.40.4
Patch foraging water rate 6 sec1.52.22.3-1.51.51.5
Seeking ratio, delayed vs. immediate footshock3.13.84.5-2.11.91.8
Distance traveled before self-admin4.86.37.6-2.82.32.4
Distance traveled after self-admin4.45.46.4-1.82.52.5
Extensor digitorum longus weight5.220.422.2-4.74.44.4
Bone: elastic displacement6.57.59.73.1-2.5-2.6
Bone: elastic work1.62.04.62.2-0.8-0.9
Bone: endosteal estimation1.02.23.1-1.71.41.3
Bone: endosteal perimeter0.91.82.7-1.61.21.1
Epididymis fat weight0.20.70.8-0.80.90.9
Delta time in closed arm before/after self-admin0.40.40.5-0.30.70.7
Delta time in open arm before/after self-admin0.20.20.30.2-0.5-0.5
Diff in mean of infusions in LGA sessions0.10.20.20.50.40.4
Delay discount exponential model param0.80.91.3-0.71.01.1
Extinction: sum of active levers before priming2.22.42.71.7-1.5-1.5
Active lever presses in extinction session 60.60.60.70.7-0.8-0.8
Bone: final force2.23.54.0-1.71.92.0
Bone: final moment1.82.93.5-1.41.81.9
Food consumed during 24 hour testing period0.81.11.7-1.30.80.9
Glucose1.62.53.4-1.81.51.4
Heart weight0.30.40.5-0.70.70.6
Delay discount hyperbolic model param0.60.71.0-0.50.91.0
Intermittent access intake day 1-15 change0.71.41.8-1.01.21.3
Intermittent access intake escalation0.71.41.9-0.81.31.4
Intermittent access intake escalation 22.83.24.3-1.22.02.1
Intermitt. access day 1 inactive lever presses0.20.71.6-1.30.50.6
Intermitt. access day 15 inactive lever presses0.10.30.4-0.50.40.6
Intermitt. access escalation Index0.20.20.3-0.60.40.5
Intermittent access day 1 total infusions1.42.33.01.1-1.7-1.6
Intermittent access day 15 total infusions0.10.20.4-0.20.50.6
Intermittent access terminal intake (last 3 days)0.81.01.2-0.81.11.1
Intermittent access total infusions0.20.20.3-0.60.40.4
Intermittent access day 1 locomotion2.12.63.31.4-1.8-1.7
Intermittent access day 15 total locomotion1.01.82.11.2-1.5-1.4
Intermittent access total locomotion0.91.11.71.3-0.9-0.9
Intermittent access standard deviation0.20.50.7-0.90.60.6
Left kidney weight0.41.73.5-1.91.00.9
Right kidney weight0.21.01.1-1.10.91.0
Cocaine induced anxiety0.10.10.2-0.40.30.3
Post-drug Anxiety1.21.32.2-1.51.00.9
Baseline Anxiety0.50.60.7-0.80.60.8
Tail length1.76.87.8-2.82.52.5
Length with tail1.14.77.5-2.71.91.8
Length without tail0.00.10.4-0.6-0.1-0.1
Times rat made contact with spout0.70.80.9-0.80.90.9
Lifetime Intake0.20.30.6-0.80.30.4
Liver weight, left0.00.00.10.1-0.2-0.2
Liver weight, right0.20.30.70.8-0.4-0.4
Locomotor activity0.00.00.1-0.10.20.2
Locomotor testing distance0.10.20.30.1-0.4-0.5
Locomotor testing rearing0.91.82.3-1.51.31.2
Locomotion in novel chamber0.20.20.40.6-0.4-0.4
Locomotion in novel chamber post-restriction1.52.43.2-0.91.81.8
Fecal boli incidents, locomotor time 11.31.92.21.5-1.3-1.3
Change in fecal boli incidents, locomotor task0.40.40.9-0.90.50.3
Time >=10cm from walls, locomotor time 10.10.10.2-0.5-0.10.1
Bouts of movement, locomotor time 11.11.32.31.5-0.9-0.9
Total resting periods, locomotor time 11.61.83.51.9-1.0-0.9
Rest time, locomotor task time 10.91.13.21.8-0.3-0.1
Distance moved, locomotor task time 11.21.84.0-2.00.90.8
Vertical activity count, locomotor time 10.51.23.3-1.80.40.3
Time >=10cm from walls, locomotor time 20.00.10.1-0.3-0.20.0
Bouts of movement, locomotor time 20.50.80.8-0.90.90.8
Total resting periods, locomotor time 20.20.40.5-0.50.70.6
Rest time, locomotor task time 20.50.61.71.3-0.2-0.2
Distance moved, locomotor task time 20.50.60.6-0.80.70.7
Vertical activity count, locomotor time 20.40.61.4-1.20.40.4
Light reinforcement 10.61.43.8-1.90.40.5
Light reinforcement 20.30.51.3-1.1-0.3-0.4
Bone: marrow area1.12.53.1-1.81.51.4
Bone: maximum diameter2.75.15.9-2.02.42.3
Bone: maximum force4.17.38.4-2.42.82.9
Bone: maximum moment3.46.07.1-2.12.62.7
Mean time between licks in bursts0.20.60.60.8-0.7-0.7
Mean num. licks in bursts2.33.53.61.9-1.9-1.8
Cd content in liver1.11.21.5-0.91.11.2
Co content in liver0.60.71.00.6-1.0-0.9
Cu content in liver1.51.82.91.7-1.1-1.1
Fe content in liver0.80.91.40.4-1.1-1.2
K content in liver0.40.40.60.4-0.8-0.7
Mg content in liver1.31.31.51.0-1.2-1.2
Mn content in liver2.22.43.4-0.81.81.8
Na content in liver1.01.11.71.3-0.9-0.9
Rb content in liver4.85.66.52.1-2.4-2.6
Se content in liver3.54.24.8-1.72.22.2
Sr content in liver0.30.30.50.20.50.7
Zn content in liver0.00.00.00.2-0.00.1
Bone: minimum diameter0.00.00.10.40.0-0.1
Time in familiar zone, hab. session 10.40.41.01.00.20.3
Time in novel zone, hab. session 12.52.53.70.8-1.8-1.9
Total zone transitions, hab. session 10.00.00.10.2-0.2-0.2
Total locomotion distance, hab. session 10.40.50.8-0.10.90.9
Locomotion velocity, hab. session 11.52.12.6-1.01.61.6
Time in familiar zone, hab. session 20.60.61.61.3-0.3-0.4
Time in novel zone, hab. session 21.31.31.80.6-1.3-1.4
Total zone transitions, hab. session 20.30.41.0-1.00.20.2
Total locomotion distance, hab. session 20.60.81.1-1.00.80.8
Locomotion velocity, hab. session 20.81.11.4-1.20.90.9
Novel to familiar place preference ratio3.74.04.61.8-2.2-2.0
Novelty place preference4.85.25.72.1-2.4-2.3
Time in novel zone, NPP test5.86.26.82.3-2.6-2.5
Total zone transitions, NPP test0.30.41.2-1.10.30.2
Total locomotion distance, NPP test1.11.42.6-1.61.00.9
Locomotion velocity, NPP test1.52.13.3-1.81.31.2
Intraocular pressure2.23.14.2-2.11.71.5
Delta distance traveled before/after self-admin0.10.10.1-0.10.30.3
Delta ambulatory time before/after self-admin0.10.10.30.5-0.1-0.2
Parametrial fat weight0.40.81.40.4-1.2-1.0
Pavlov. Cond. lever latency7.08.810.83.3-2.9-2.7
Pavlov. Cond. magazine entry latency0.30.40.4-0.70.60.6
Pavlov. Cond. change in total contacts2.62.73.8-2.01.51.4
Pavlov. Cond. index score3.24.04.6-2.12.01.9
Pavlov. Cond. latency score2.93.74.3-2.11.91.8
Pavlov. Cond. lever contacts6.57.89.4-3.12.72.6
Pavlov. Cond. magazine entry number0.50.60.70.8-0.8-0.8
Pavlov. Cond. intertrial magazine entries0.20.30.4-0.50.60.5
Pavlov. Cond. lever-magazine prob. diff.3.24.04.2-2.12.01.9
Pavlov. Cond. response bias3.64.55.3-2.32.12.0
Pavlov. Cond. lever latency3.24.35.51.5-2.3-2.3
Pavlov. Cond. magazine entry latency0.10.10.30.5-0.00.0
Pavlov. Cond. change in total contacts1.01.72.5-0.41.51.6
Pavlov. Cond. index score0.60.81.2-0.11.01.1
Pavlov. Cond. latency score0.81.01.6-0.31.21.3
Pavlov. Cond. lever contacts2.43.34.3-1.22.02.1
Pavlov. Cond. magazine entry number0.50.61.00.0-1.0-1.0
Pavlov. Cond. intertrial magazine entries0.10.20.3-0.50.40.4
Pavlov. Cond. lever-magazine prob. diff.0.60.81.2-0.11.11.1
Pavlov. Cond. response bias1.41.92.7-0.61.61.6
Time in closed arm before self-admin0.60.81.00.7-1.0-1.0
Time in closed arm after self-admin0.10.10.20.5-0.2-0.1
Time in open arm before self-admin0.70.71.2-1.10.70.7
Time in open arm after self-admin0.60.61.1-1.00.70.6
Bone: periosteal estimation2.04.24.8-1.92.22.0
Bone: periosteal perimeter0.50.91.1-1.10.90.8
Bone: post-yield work1.92.83.6-1.91.51.6
Progressive ratio test 1 active lever presses0.10.10.1-0.3-0.3-0.3
Progressive ratio test 1 breakpoint0.10.10.2-0.4-0.3-0.2
Progressive ratio test 1 inactive lever presses0.60.92.2-1.50.50.6
Progressive ratio test 2 active lever presses0.10.20.2-0.2-0.4-0.5
Progressive ratio test 2 breakpoint0.20.20.3-0.2-0.5-0.5
Progressive ratio test 2 inactive lever presses0.20.40.5-0.70.60.6
Incentive Sensitization - Responses0.20.20.5-0.70.20.2
Incentive Sensitization - Breakpoint0.10.10.4-0.60.10.1
Sum of active levers in priming session hrs 5-64.84.55.71.5-2.3-2.4
Progressive ratio0.20.30.50.0-0.7-0.6
Food seeking constrained by brief footshock7.18.715.0-3.92.32.4
Seeking ratio, punishment vs. effort2.94.24.5-2.12.02.0
Retroperitoneal fat weight0.52.02.41.6-1.3-1.3
Reaction time number correct0.00.10.1-0.3-0.3-0.2
Reaction time mean minus median0.41.01.50.31.21.2
Reaction time mean minus median AUC0.71.82.8-0.41.61.7
Reaction time num false alarms0.30.50.70.00.80.9
Reaction time num false alarms AUC0.71.11.4-0.61.21.2
Reaction time trials correct on left0.00.10.1-0.3-0.3-0.2
Reaction time trials on left0.10.10.2-0.2-0.4-0.3
Reaction time mean0.91.43.11.8-0.7-0.7
Reaction time mean AUC0.91.43.41.9-0.7-0.7
Median of all reaction times2.23.14.62.1-1.5-1.6
Reaction time omissions2.23.23.92.0-1.7-1.7
Reaction time false alarm rate0.30.40.60.10.80.7
Reaction time premature initiation rate2.02.74.62.2-1.4-1.3
Reaction time premature initiations1.32.33.31.8-1.4-1.3
Std. dev. reaction times0.20.41.01.00.40.4
Reaction time trials completed0.10.10.2-0.2-0.4-0.3
Reaction time trials AUC0.10.10.2-0.1-0.4-0.3
Run reversals in cocaine runway, females0.10.10.20.4-0.2-0.2
Run reversals in cocaine runway, males0.00.00.00.2-0.1-0.1
Latency to leave start box in cocaine runway0.91.01.4-0.71.21.0
Latency to leave start box in cocaine runway, F0.20.20.30.3-0.4-0.6
Latency to leave start box in cocaine runway, M4.13.94.4-1.82.12.0
Std. dev. time between licks in bursts0.20.30.40.7-0.5-0.5
Total sessions with >9 infusions0.40.51.0-1.00.50.5
Short access day 1 total inactive lever presses0.81.12.6-1.60.50.7
Short access day 10 total inactive lever presses0.41.01.4-1.00.91.2
Short access day 1 total infusions0.50.71.5-1.20.50.5
Short access day 10 total infusions0.20.30.4-0.3-0.6-0.6
Short access total infusions0.10.20.4-0.6-0.1-0.1
Short access day 1 locomotion1.72.12.51.2-1.6-1.6
Short access day 10 total locomotion0.61.11.71.3-1.0-0.8
Short access total locomotion0.70.81.10.7-1.0-1.0
One hour access (0.3 mA shock)0.20.20.4-0.60.30.4
Compulsive drug intake0.00.00.10.10.20.2
One hour access (shock baseline)0.10.10.3-0.6-0.2-0.2
Social response proportion2.83.23.41.8-1.8-1.7
Social responses0.50.60.7-0.90.80.8
Social time0.10.10.20.1-0.5-0.5
Soleus weight0.30.91.3-0.6-1.1-1.0
Bone: stiffness5.69.110.3-2.83.03.2
Tibialis anterior weight7.826.332.9-5.74.94.7
Time to tail flick, vehicle, before self-admin1.51.62.21.5-1.1-1.1
Time to tail flick, vehicle, after self-admin0.00.10.1-0.10.30.2
Time to tail flick, test, before self-admin0.70.70.9-0.90.80.7
Time to tail flick, test, after self-admin0.90.91.2-0.71.11.1
Delta time to tail flick, vehicle, before/after SA0.70.60.9-1.00.70.6
Delta time to tail flick, test, before/after SA0.20.20.40.6-0.2-0.2
Tibia length0.00.10.4-0.60.1-0.1
Ambulatory time before self-admin3.04.55.8-2.41.92.0
Ambulatory time after self-admin1.61.92.0-1.31.41.4
Bone: tissue strength0.10.10.2-0.30.30.4
Total heroin consumption1.01.11.40.8-1.1-1.2
Bone: trabecular number0.91.41.7-1.01.21.3
Bone: trabecular spacing0.10.10.20.00.50.3
Bone: trabecular thickness0.20.20.50.7-0.3-0.3
Bone: trabecular tissue density4.16.06.4-2.42.52.4
Water consumed over 24 hours1.31.71.8-1.31.31.3
Number of responses in last shaping day0.60.71.0-0.2-1.0-1.0