Hub : Genes

Nudt2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Nudt2 0.07 0.05 2.9e-05 0.06 0.06 0.05 0.06 4.4e-06 3.2e-06 3.0e-05 7.5e-06
2 Liver gene expression Nudt2 0.03 0.02 6.9e-03 0.02 0.01 0.01 0.01 4.8e-03 3.6e-02 4.1e-02 1.6e-02
3 PL gene expression Nudt2 0.04 0.03 1.7e-03 0.02 0.02 0.02 0.02 1.5e-03 1.9e-03 2.2e-03 1.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density1.22.02.2-1.3-1.5-1.5
Area under the delay curve0.91.01.50.61.01.2
BMI with tail1.85.96.7-2.3-2.4-2.6
BMI without tail4.49.211.9-3.5-2.7-2.9
Body weight2.811.713.8-3.7-3.2-3.4
Weight adjusted by age0.20.20.2-0.50.40.5
Bone surface0.71.21.6-1.2-1.0-0.9
Bone volume0.71.21.4-1.1-1.2-1.0
Breakpoint value in progressive ratio session1.01.01.60.31.21.3
Number of licking bursts6.47.57.8-2.6-2.8-2.8
Context. condit. distance diff. score0.10.10.20.40.00.3
Locomotion velocity, session 10.80.81.6-1.30.60.7
Locomotion distance, session 10.30.30.8-0.90.30.3
Locomotion velocity, session 22.02.42.6-1.4-1.6-1.6
Locomotion distance, session 21.62.34.2-2.0-1.1-1.2
Locomotion velocity, session 30.10.10.3-0.60.10.2
Locomotion distance, session 31.71.93.0-1.7-1.2-1.1
Stereotopy head waving bouts, day 30.00.10.1-0.3-0.30.0
Stereotopy head waving duration, day 30.00.00.00.2-0.20.1
Locomotion velocity, session 70.00.00.00.2-0.10.2
Locomotion distance, session 70.20.20.4-0.6-0.4-0.3
Stereotopy head waving bouts, day 73.03.43.7-1.8-1.9-1.8
Stereotopy head waving duration, day 71.11.31.6-1.1-1.2-1.1
Locomotion velocity, session 80.10.10.3-0.5-0.00.3
Locomotion distance, session 80.10.20.6-0.8-0.1-0.0
Degree of sensitization distance0.60.61.11.10.50.7
Degree of sensitization stereotypy1.61.72.0-1.3-1.4-1.3
Conditioned locomotion0.10.10.2-0.20.20.5
Cocaine response after cond. corrected1.82.02.80.81.71.6
Cocaine response after cond. not corrected1.51.72.40.61.51.5
Cocaine response before conditioning1.21.51.9-1.1-1.4-1.1
Saline control response1.21.62.6-1.6-1.1-1.0
Bone: connectivity density0.50.81.0-0.7-0.9-1.0
Bone: cortical apparent density0.10.20.30.5-0.5-0.3
Bone: cortical area2.43.64.0-1.7-2.0-2.0
Bone: cortical porosity0.60.61.00.81.00.5
Bone: cortical porosity0.00.10.10.10.4-0.1
Bone: cortical thickness0.91.52.2-0.8-1.3-1.5
Bone: cortical thickness0.10.10.20.50.0-0.1
Bone: cortical tissue density0.10.20.30.5-0.4-0.2
Condit. Reinf. active minus inactive responses0.70.70.9-0.8-1.0-0.8
Condit. Reinf. active-inactive response ratio0.50.50.80.90.50.7
Condit. Reinf. active responses3.44.25.3-1.9-2.3-1.9
Condit. Reinf. inactive responses3.94.65.6-1.9-2.4-2.1
Incentive salience index mean4.55.56.4-2.5-2.3-2.2
Condit. Reinf. lever presses9.913.217.6-4.2-3.3-3.3
Condit. Reinf. active minus inactive responses0.50.60.7-0.8-0.7-0.8
Condit. Reinf. active-inactive response ratio0.00.00.0-0.00.1-0.1
Condit. Reinf. active responses2.23.03.3-1.8-1.7-1.7
Condit. Reinf. inactive responses4.15.05.7-2.0-2.3-2.4
Condit. Reinf. lever presses3.04.15.4-1.5-2.3-2.1
Condit. Reinf. lever reinforcers received2.63.73.9-2.0-1.9-1.9
Conditioned reinforcement - actives1.01.01.2-0.8-1.1-1.1
Conditioned reinforcement - inactives0.70.71.2-0.6-0.8-1.1
Conditioned locomotion0.50.60.8-0.9-0.7-0.7
Patch foraging indifference point 0 sec0.40.61.4-1.20.50.4
Patch foraging indifference point AUC5.56.38.5-2.9-2.2-2.4
Delay disc. indifference point, 0s delay1.31.41.71.01.21.3
Delay disc. indifference point, 16s delay1.71.82.40.71.61.6
Delay disc. indifference point, 2s delay0.20.20.4-0.1-0.7-0.5
Delay disc. indifference point, 24s delay0.40.40.50.50.70.7
Delay disc. indifference point, 4s delay0.10.20.20.40.40.4
Delay disc. indifference point, 8s delay0.10.10.20.00.20.4
Indifference point function ln k1.62.22.81.71.11.6
Indifference point function log k1.62.22.81.71.11.6
Patch foraging total patch changes 0 sec0.50.82.3-1.50.1-0.1
Patch foraging total patch changes 12 sec1.31.72.6-1.6-0.8-1.3
Patch foraging total patch changes 18 sec0.40.51.1-1.0-0.4-0.5
Patch foraging total patch changes 24 sec1.51.83.4-1.8-0.9-1.2
Patch foraging total patch changes 6 sec1.62.45.4-2.3-0.6-1.2
Patch foraging time to switch 0 sec1.82.74.62.11.41.2
Patch foraging water rate 0 sec0.91.43.1-1.8-0.7-0.7
Patch foraging water rate 12 sec0.10.10.1-0.4-0.4-0.1
Patch foraging water rate 18 sec0.40.50.9-0.4-0.7-1.0
Patch foraging water rate 24 sec0.10.10.20.3-0.5-0.3
Patch foraging water rate 6 sec1.52.22.7-1.4-1.6-1.4
Seeking ratio, delayed vs. immediate footshock3.33.83.9-2.0-1.9-1.9
Distance traveled before self-admin6.16.48.7-2.9-2.4-2.2
Distance traveled after self-admin3.13.44.6-1.4-2.1-1.9
Extensor digitorum longus weight5.421.122.2-4.7-4.6-4.5
Bone: elastic displacement5.15.87.52.72.22.3
Bone: elastic work1.62.04.62.10.90.8
Bone: endosteal estimation1.12.33.2-1.8-1.6-1.1
Bone: endosteal perimeter1.02.23.3-1.8-1.5-1.0
Epididymis fat weight0.51.11.8-1.4-0.8-0.9
Delta time in closed arm before/after self-admin1.61.51.8-1.0-1.3-1.3
Delta time in open arm before/after self-admin0.30.30.50.30.50.7
Diff in mean of infusions in LGA sessions0.00.00.10.3-0.10.1
Delay discount exponential model param0.80.91.3-0.6-1.0-1.1
Extinction: sum of active levers before priming1.21.21.61.31.01.0
Active lever presses in extinction session 62.12.12.51.11.51.6
Bone: final force1.52.52.6-1.5-1.6-1.6
Bone: final moment1.21.92.2-1.2-1.5-1.5
Food consumed during 24 hour testing period0.91.11.9-1.4-0.7-0.9
Glucose0.71.01.7-1.3-0.7-0.9
Heart weight0.40.61.1-1.0-0.4-0.7
Delay discount hyperbolic model param0.70.81.2-0.5-0.9-1.1
Intermittent access intake day 1-15 change0.90.91.2-0.6-1.1-1.1
Intermittent access intake escalation0.90.90.9-0.9-1.0-1.0
Intermittent access intake escalation 21.91.92.6-0.9-1.6-1.5
Intermitt. access day 1 inactive lever presses0.40.40.8-0.9-0.5-0.5
Intermitt. access day 15 inactive lever presses0.10.10.3-0.6-0.0-0.4
Intermitt. access escalation Index0.70.61.2-1.1-0.6-0.6
Intermittent access day 1 total infusions0.60.71.00.51.00.9
Intermittent access day 15 total infusions0.30.40.5-0.7-0.5-0.6
Intermittent access terminal intake (last 3 days)1.31.41.5-1.2-1.2-1.2
Intermittent access total infusions0.60.71.1-1.0-0.7-0.8
Intermittent access day 1 locomotion2.12.22.81.21.71.6
Intermittent access day 15 total locomotion1.21.31.51.01.21.2
Intermittent access total locomotion0.50.60.80.90.70.6
Intermittent access standard deviation0.60.60.7-0.7-0.7-0.8
Left kidney weight0.41.02.1-1.5-0.4-0.8
Right kidney weight0.00.10.2-0.50.3-0.2
Cocaine induced anxiety0.40.50.50.70.60.7
Post-drug Anxiety0.60.60.8-0.9-0.7-0.7
Baseline Anxiety0.70.71.0-0.7-0.8-1.0
Tail length2.26.69.0-3.0-2.4-2.3
Length with tail0.72.64.4-2.1-1.4-1.2
Length without tail0.30.70.80.70.90.9
Times rat made contact with spout0.80.91.4-0.6-1.2-1.0
Lifetime Intake0.81.01.8-1.4-0.7-0.8
Liver weight, left0.50.71.0-1.0-0.7-0.9
Liver weight, right0.00.00.0-0.0-0.10.2
Locomotor activity0.00.00.1-0.20.0-0.3
Locomotor testing distance0.00.10.1-0.30.20.1
Locomotor testing rearing1.32.02.7-1.6-1.3-1.3
Locomotion in novel chamber0.10.10.20.40.20.1
Locomotion in novel chamber post-restriction2.22.63.4-1.0-1.8-1.8
Fecal boli incidents, locomotor time 11.71.81.91.31.41.3
Change in fecal boli incidents, locomotor task0.80.81.6-1.3-0.7-0.5
Time >=10cm from walls, locomotor time 10.00.00.1-0.30.1-0.1
Bouts of movement, locomotor time 10.91.01.71.30.80.9
Total resting periods, locomotor time 11.31.42.81.70.80.9
Rest time, locomotor task time 10.91.02.81.70.30.2
Distance moved, locomotor task time 11.71.83.7-1.9-1.0-0.9
Vertical activity count, locomotor time 10.91.02.2-1.5-0.6-0.5
Time >=10cm from walls, locomotor time 20.00.00.1-0.30.1-0.1
Bouts of movement, locomotor time 20.80.91.2-0.8-1.1-0.9
Total resting periods, locomotor time 20.50.50.7-0.5-0.9-0.7
Rest time, locomotor task time 20.30.41.01.00.30.2
Distance moved, locomotor task time 20.30.40.4-0.6-0.6-0.7
Vertical activity count, locomotor time 20.20.30.5-0.7-0.4-0.4
Light reinforcement 10.91.74.4-2.1-0.4-0.8
Light reinforcement 20.50.61.5-1.20.60.2
Bone: marrow area1.22.63.3-1.8-1.7-1.2
Bone: maximum diameter2.44.55.2-2.1-2.3-2.0
Bone: maximum force3.56.16.5-2.4-2.5-2.5
Bone: maximum moment2.84.75.2-2.0-2.3-2.3
Mean time between licks in bursts0.20.30.60.70.20.7
Mean num. licks in bursts2.63.23.71.91.61.8
Cd content in liver1.11.21.8-0.7-1.3-1.2
Co content in liver0.91.11.40.91.11.2
Cu content in liver0.40.51.31.10.20.6
Fe content in liver0.20.30.7-0.9-0.10.3
K content in liver0.80.81.40.41.20.9
Mg content in liver1.31.31.51.01.21.2
Mn content in liver0.60.71.3-0.3-0.8-1.2
Na content in liver0.91.01.31.10.90.9
Rb content in liver4.65.76.62.22.62.4
Se content in liver2.43.04.3-1.4-1.7-2.1
Sr content in liver0.60.60.8-0.5-0.9-0.8
Zn content in liver0.10.20.40.1-0.6-0.3
Bone: minimum diameter0.00.10.10.4-0.10.2
Time in familiar zone, hab. session 10.60.51.21.1-0.6-0.3
Time in novel zone, hab. session 11.61.63.40.51.11.9
Total zone transitions, hab. session 10.10.10.10.10.40.3
Total locomotion distance, hab. session 10.20.30.7-0.2-0.4-0.9
Locomotion velocity, hab. session 11.01.42.5-1.0-0.8-1.6
Time in familiar zone, hab. session 20.50.51.41.20.20.4
Time in novel zone, hab. session 21.01.01.70.51.01.3
Total zone transitions, hab. session 20.30.41.1-1.00.1-0.2
Total locomotion distance, hab. session 20.50.61.0-1.0-0.5-0.8
Locomotion velocity, hab. session 20.50.71.2-1.1-0.5-0.9
Novel to familiar place preference ratio3.33.44.21.51.92.1
Novelty place preference4.74.75.31.92.32.3
Time in novel zone, NPP test5.35.46.42.12.42.5
Total zone transitions, NPP test0.30.51.3-1.2-0.1-0.2
Total locomotion distance, NPP test0.91.22.8-1.7-0.3-0.9
Locomotion velocity, NPP test1.11.63.3-1.8-0.4-1.1
Intraocular pressure1.92.73.6-1.9-1.6-1.3
Delta distance traveled before/after self-admin0.10.10.30.60.10.1
Delta ambulatory time before/after self-admin0.50.51.11.10.50.5
Parametrial fat weight0.10.10.4-0.60.0-0.0
Pavlov. Cond. lever latency8.510.812.83.63.23.1
Pavlov. Cond. magazine entry latency0.60.81.6-0.8-1.3-0.5
Pavlov. Cond. change in total contacts2.93.14.2-2.0-1.7-1.5
Pavlov. Cond. index score3.94.95.8-2.3-2.4-2.0
Pavlov. Cond. latency score3.64.65.4-2.2-2.3-1.9
Pavlov. Cond. lever contacts6.37.48.2-2.9-2.8-2.5
Pavlov. Cond. magazine entry number1.01.21.91.11.40.8
Pavlov. Cond. intertrial magazine entries0.30.30.4-0.5-0.6-0.6
Pavlov. Cond. lever-magazine prob. diff.3.64.55.6-2.0-2.4-1.9
Pavlov. Cond. response bias3.74.45.4-2.2-2.3-1.8
Pavlov. Cond. lever latency4.76.410.61.73.32.4
Pavlov. Cond. magazine entry latency0.20.20.40.5-0.70.2
Pavlov. Cond. change in total contacts1.82.45.1-0.5-2.3-1.4
Pavlov. Cond. index score1.21.53.8-0.2-1.9-0.9
Pavlov. Cond. latency score1.61.94.5-0.3-2.1-1.1
Pavlov. Cond. lever contacts2.53.56.3-1.2-2.5-1.6
Pavlov. Cond. magazine entry number0.91.12.7-0.11.60.7
Pavlov. Cond. intertrial magazine entries0.20.30.5-0.70.5-0.5
Pavlov. Cond. lever-magazine prob. diff.1.21.53.7-0.2-1.9-0.9
Pavlov. Cond. response bias1.52.14.3-0.7-2.1-1.2
Time in closed arm before self-admin3.94.44.62.12.12.1
Time in closed arm after self-admin0.40.40.50.70.70.5
Time in open arm before self-admin2.52.84.3-2.1-1.5-1.4
Time in open arm after self-admin1.21.32.2-1.5-1.1-0.8
Bone: periosteal estimation1.73.64.0-2.0-2.0-1.7
Bone: periosteal perimeter0.50.91.5-1.2-0.9-0.6
Bone: post-yield work1.52.12.9-1.7-1.4-1.2
Progressive ratio test 1 active lever presses0.50.50.7-0.8-0.6-0.6
Progressive ratio test 1 breakpoint0.70.71.0-1.0-0.8-0.7
Progressive ratio test 1 inactive lever presses0.70.81.7-1.3-0.5-0.6
Progressive ratio test 2 active lever presses0.10.10.4-0.6-0.1-0.0
Progressive ratio test 2 breakpoint0.00.10.1-0.40.10.2
Progressive ratio test 2 inactive lever presses0.60.71.1-1.0-0.7-0.7
Incentive Sensitization - Responses0.30.30.5-0.7-0.4-0.4
Incentive Sensitization - Breakpoint0.10.10.2-0.5-0.3-0.2
Sum of active levers in priming session hrs 5-64.94.85.91.82.32.4
Progressive ratio0.30.30.50.30.70.7
Food seeking constrained by brief footshock6.78.312.6-3.6-2.4-2.5
Seeking ratio, punishment vs. effort3.23.94.0-2.0-2.0-2.0
Retroperitoneal fat weight0.10.20.40.60.40.4
Reaction time number correct0.10.10.1-0.30.20.3
Reaction time mean minus median0.91.11.80.1-1.3-1.3
Reaction time mean minus median AUC1.51.92.9-0.5-1.6-1.7
Reaction time num false alarms0.30.40.60.1-0.7-0.8
Reaction time num false alarms AUC0.70.91.3-0.6-1.0-1.1
Reaction time trials correct on left0.10.10.1-0.30.20.3
Reaction time trials on left0.10.10.2-0.20.30.4
Reaction time mean0.81.12.91.70.00.7
Reaction time mean AUC0.91.33.31.8-0.10.7
Median of all reaction times1.82.44.62.10.71.5
Reaction time omissions1.01.32.21.50.51.2
Reaction time false alarm rate0.20.30.50.2-0.6-0.7
Reaction time premature initiation rate2.02.64.02.01.51.2
Reaction time premature initiations1.62.22.71.71.51.3
Std. dev. reaction times0.40.50.80.9-0.7-0.4
Reaction time trials completed0.10.10.2-0.20.30.4
Reaction time trials AUC0.10.10.2-0.10.30.4
Run reversals in cocaine runway, females0.10.10.30.50.30.2
Run reversals in cocaine runway, males0.00.00.00.2-0.1-0.1
Latency to leave start box in cocaine runway1.11.21.4-1.0-1.2-1.1
Latency to leave start box in cocaine runway, F0.10.10.1-0.00.30.3
Latency to leave start box in cocaine runway, M2.52.42.6-1.6-1.6-1.4
Std. dev. time between licks in bursts0.40.40.60.80.70.5
Total sessions with >9 infusions0.20.20.5-0.70.0-0.0
Short access day 1 total inactive lever presses2.62.94.6-2.2-1.3-1.5
Short access day 10 total inactive lever presses0.40.40.6-0.8-0.5-0.7
Short access day 1 total infusions2.32.54.3-2.1-1.2-1.3
Short access day 10 total infusions0.30.41.1-1.0-0.0-0.0
Short access total infusions0.50.61.5-1.2-0.4-0.4
Short access day 1 locomotion0.60.71.00.31.01.0
Short access day 10 total locomotion0.91.01.51.20.90.8
Short access total locomotion0.10.10.2-0.10.40.5
One hour access (0.3 mA shock)0.30.30.8-0.9-0.3-0.3
Compulsive drug intake0.00.00.1-0.30.0-0.0
One hour access (shock baseline)0.20.20.7-0.8-0.10.0
Social response proportion3.13.44.21.72.01.7
Social responses0.30.40.7-0.8-0.5-0.6
Social time0.10.10.40.10.30.6
Soleus weight0.20.71.3-0.40.71.1
Bone: stiffness4.57.17.9-2.6-2.6-2.8
Tibialis anterior weight7.425.530.4-5.5-5.0-4.5
Time to tail flick, vehicle, before self-admin2.12.22.51.61.51.3
Time to tail flick, vehicle, after self-admin0.00.00.0-0.1-0.10.2
Time to tail flick, test, before self-admin0.60.60.9-0.5-0.9-0.8
Time to tail flick, test, after self-admin0.10.10.1-0.1-0.4-0.2
Delta time to tail flick, vehicle, before/after SA0.50.50.7-0.8-0.8-0.5
Delta time to tail flick, test, before/after SA0.50.50.60.60.70.7
Tibia length0.10.20.5-0.70.10.2
Ambulatory time before self-admin3.84.06.4-2.5-1.7-1.6
Ambulatory time after self-admin0.91.01.3-1.0-1.1-0.9
Bone: tissue strength0.20.20.2-0.4-0.4-0.4
Total heroin consumption0.20.30.50.30.50.7
Bone: trabecular number1.11.72.2-1.1-1.3-1.5
Bone: trabecular spacing0.00.10.10.1-0.2-0.3
Bone: trabecular thickness0.10.10.20.4-0.20.3
Bone: trabecular tissue density3.44.85.1-2.1-2.2-2.2
Water consumed over 24 hours1.31.61.7-1.2-1.3-1.3
Number of responses in last shaping day0.50.51.2-1.10.40.4