Aldh3b2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Aldh3b2	0.24	0.13	0.0e+00	0.16	0.17	0.17	0.17	3.6e-17	1.3e-18	1.1e-18	1.6e-18
2	IL	mRNA stability	Aldh3b2	0.22	0.15	4.8e-03	0.1	0.03	0	0.06	2.6e-03	7.1e-02	2.4e-01	1.5e-02
3	Brain	mRNA stability	Aldh3b2	0.12	0.09	1.9e-06	0.04	0.06	0.06	0.06	1.4e-04	1.4e-06	4.4e-06	1.7e-06
4	IL	gene expression	Aldh3b2	0.2	0.14	8.1e-03	0.09	0.09	0.05	0.08	3.4e-03	3.1e-03	2.0e-02	6.0e-03
5	BLA	mRNA stability	Aldh3b2	0.06	0.05	4.0e-03	0.05	0.03	0.04	0.03	1.3e-03	7.9e-03	4.6e-03	7.0e-03
6	OFC	gene expression	Aldh3b2	0.58	0.18	2.1e-10	0.34	0.24	0.32	0.33	5.7e-09	2.5e-06	2.3e-08	1.2e-08
7	PL	gene expression	Aldh3b2	0.57	0.46	0.0e+00	0.34	0.33	0.33	0.33	1.9e-38	4.2e-37	1.0e-37	7.7e-37
8	Brain	gene expression	Aldh3b2	0.34	0.17	0.0e+00	0.26	0.24	0.27	0.27	2.5e-24	1.3e-22	4.3e-25	1.9e-25
9	BLA	gene expression	Aldh3b2	0.3	0.15	1.3e-14	0.21	0.24	0.23	0.23	2.2e-11	6.3e-13	1.7e-12	2.6e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	2.8	4.6	6.6	-1.3	-0.5	2.0	2.5	-1.9	-2.6	-2.6	2.5	2.6
Area under the delay curve	0.9	0.9	2.1	-0.3	0.2	0.6	1.0	-1.5	-0.9	-1.1	1.1	1.2
BMI with tail	3.6	11.8	15.2	-3.4	-2.7	3.8	3.6	-3.9	-3.4	-3.4	3.5	3.1
BMI without tail	2.1	4.3	5.6	-2.1	-1.7	2.4	2.2	-2.0	-2.2	-2.0	2.0	1.9
Body weight	2.0	8.4	17.6	-4.0	-4.2	3.8	2.5	-2.4	-2.1	-2.2	2.2	1.3
Weight adjusted by age	0.6	0.7	2.3	-1.5	-1.3	1.1	0.6	-0.6	-0.4	-0.5	0.6	0.2
Bone surface	4.3	7.6	9.1	-2.7	-1.8	3.0	3.0	-2.6	-3.0	-3.0	2.8	2.7
Bone volume	2.5	4.2	5.6	-1.6	-0.7	2.0	2.3	-2.0	-2.4	-2.4	2.3	2.3
Breakpoint value in progressive ratio session	1.2	1.3	3.0	-1.7	-1.7	1.5	1.0	-0.6	-0.8	-0.9	0.7	0.5
Number of licking bursts	0.1	0.1	0.2	-0.3	0.1	0.3	0.4	-0.3	-0.4	-0.4	0.4	0.4
Context. condit. distance diff. score	0.3	0.4	1.6	1.0	1.3	-0.7	-0.2	0.1	0.0	0.0	-0.1	0.2
Locomotion velocity, session 1	0.0	0.0	0.0	-0.1	0.1	0.1	0.1	-0.1	-0.1	-0.1	0.0	0.1
Locomotion distance, session 1	2.0	2.5	3.2	-1.4	-0.4	1.5	1.8	-1.8	-1.7	-1.7	1.8	1.7
Locomotion velocity, session 2	1.0	1.2	3.2	-1.8	-1.8	1.5	0.8	-0.7	-0.6	-0.6	0.6	0.2
Locomotion distance, session 2	1.2	1.7	2.7	-1.7	-0.9	1.5	1.3	-1.3	-1.2	-1.2	1.2	1.1
Locomotion velocity, session 3	1.5	1.7	2.6	-0.5	0.0	1.1	1.5	-1.5	-1.5	-1.5	1.5	1.6
Locomotion distance, session 3	0.1	0.1	0.2	-0.2	0.1	0.3	0.4	-0.5	-0.4	-0.4	0.4	0.4
Stereotopy head waving bouts, day 3	0.9	1.0	2.0	0.1	0.6	0.5	1.1	-1.1	-1.2	-1.2	1.2	1.4
Stereotopy head waving duration, day 3	0.4	0.4	1.3	0.8	1.2	-0.3	0.4	-0.4	-0.6	-0.6	0.5	0.9
Locomotion velocity, session 7	1.0	1.1	1.7	-0.5	0.2	0.8	1.2	-1.3	-1.2	-1.2	1.2	1.3
Locomotion distance, session 7	0.3	0.4	0.8	-0.9	-0.6	0.7	0.7	-0.6	-0.6	-0.6	0.6	0.5
Stereotopy head waving bouts, day 7	0.7	0.8	1.5	0.4	0.9	0.2	0.9	-1.0	-1.0	-1.0	1.0	1.2
Stereotopy head waving duration, day 7	2.2	2.6	3.3	-1.1	-0.6	1.6	1.8	-1.8	-1.8	-1.8	1.8	1.8
Locomotion velocity, session 8	0.7	0.8	1.9	-1.4	-1.4	1.2	0.7	-0.6	-0.6	-0.6	0.5	0.3
Locomotion distance, session 8	0.1	0.2	0.4	0.0	0.6	-0.0	0.4	-0.5	-0.5	-0.5	0.4	0.6
Degree of sensitization distance	0.5	0.5	0.7	-0.8	-0.6	0.8	0.8	-0.7	-0.7	-0.7	0.7	0.7
Degree of sensitization stereotypy	0.8	0.9	1.2	-0.6	-0.2	0.9	1.1	-1.1	-1.1	-1.1	1.1	1.1
Conditioned locomotion	1.0	1.2	3.1	-1.2	-1.8	0.3	-0.8	0.9	1.0	1.0	-1.0	-1.4
Cocaine response after cond. corrected	0.0	0.1	0.2	0.4	0.4	-0.2	0.0	0.0	-0.1	-0.1	0.0	0.2
Cocaine response after cond. not corrected	0.2	0.2	0.4	0.2	0.4	0.1	0.5	-0.5	-0.5	-0.5	0.5	0.7
Cocaine response before conditioning	0.2	0.3	0.5	-0.5	-0.2	0.5	0.6	-0.7	-0.5	-0.5	0.6	0.5
Saline control response	1.4	1.8	4.3	-2.1	-2.0	1.8	1.1	-0.9	-0.9	-0.9	0.9	0.5
Bone: connectivity density	4.7	7.3	9.3	-2.4	-1.7	3.0	3.0	-2.2	-3.0	-3.0	2.9	2.7
Bone: cortical apparent density	0.2	0.2	1.0	-0.8	-1.0	0.5	0.1	-0.0	0.0	0.0	-0.0	-0.2
Bone: cortical area	0.2	0.4	0.9	-0.5	-0.9	0.1	-0.4	0.6	0.5	0.5	-0.6	-0.8
Bone: cortical porosity	0.1	0.1	0.3	0.0	-0.0	0.2	0.3	-0.6	-0.3	-0.3	0.3	0.3
Bone: cortical porosity	0.2	0.2	0.4	-0.5	-0.7	0.5	0.3	-0.6	-0.3	-0.3	0.3	0.2
Bone: cortical thickness	1.3	2.2	8.6	-2.0	-2.9	0.9	-0.6	1.0	0.9	0.9	-1.0	-1.6
Bone: cortical thickness	0.6	0.7	3.1	-1.4	-1.8	0.8	-0.0	0.6	0.2	0.2	-0.3	-0.6
Bone: cortical tissue density	0.2	0.3	1.2	-0.8	-1.1	0.6	0.1	-0.0	0.1	0.1	-0.0	-0.3
Condit. Reinf. active minus inactive responses	0.5	0.5	0.8	-0.5	-0.0	0.7	0.8	-0.9	-0.8	-0.8	0.9	0.8
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.0	0.3	0.3	0.5	-0.6	-0.5	-0.5	0.6	0.6
Condit. Reinf. active responses	0.0	0.1	0.1	-0.1	0.1	0.2	0.2	-0.4	-0.2	-0.2	0.3	0.3
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.3	0.2	-0.3	-0.3	0.2	0.3	0.3	-0.3	-0.3
Incentive salience index mean	0.4	0.5	0.7	-0.6	-0.2	0.7	0.7	-0.8	-0.7	-0.7	0.8	0.7
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.3	-0.2	-0.0	-0.1	0.0	0.2	0.2	-0.1	-0.2
Condit. Reinf. active minus inactive responses	0.7	0.9	1.7	0.4	1.0	0.2	0.9	-1.1	-1.0	-1.0	1.1	1.3
Condit. Reinf. active-inactive response ratio	0.6	0.6	2.6	1.2	1.6	-0.7	0.1	-0.3	-0.3	-0.3	0.3	0.7
Condit. Reinf. active responses	1.4	1.9	3.0	-0.3	0.3	0.9	1.5	-1.7	-1.6	-1.6	1.6	1.7
Condit. Reinf. inactive responses	1.7	2.1	2.4	-1.3	-1.0	1.5	1.5	-1.6	-1.5	-1.5	1.5	1.4
Condit. Reinf. lever presses	1.4	1.9	2.2	-1.4	-0.9	1.5	1.5	-1.4	-1.4	-1.4	1.4	1.3
Condit. Reinf. lever reinforcers received	1.6	2.2	3.3	-0.6	0.1	1.2	1.7	-1.8	-1.7	-1.7	1.8	1.8
Conditioned reinforcement - actives	0.7	0.7	0.9	0.8	0.6	-0.9	-1.0	0.7	1.0	0.9	-0.7	-0.9
Conditioned reinforcement - inactives	2.7	3.1	7.7	2.8	2.7	-2.4	-1.4	0.9	1.3	1.2	-0.9	-0.6
Conditioned locomotion	7.1	8.5	13.9	3.7	3.5	-3.7	-2.9	2.3	2.7	2.6	-2.4	-2.0
Patch foraging indifference point 0 sec	0.1	0.2	1.2	1.1	0.7	-0.5	-0.2	-0.3	0.1	0.1	-0.1	0.0
Patch foraging indifference point AUC	0.4	0.5	1.7	-1.2	-1.3	0.7	0.0	-0.4	0.1	0.2	-0.1	-0.5
Delay disc. indifference point, 0s delay	1.6	1.7	3.8	-0.4	-0.0	1.0	1.5	-1.9	-1.5	-1.4	1.3	1.6
Delay disc. indifference point, 16s delay	0.5	0.5	2.0	1.1	1.4	-0.8	-0.2	-0.3	0.2	0.1	-0.2	0.2
Delay disc. indifference point, 2s delay	0.3	0.3	0.6	0.1	0.5	0.0	0.5	-0.8	-0.6	-0.7	0.5	0.8
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.1	-0.2	-0.1	-0.4	0.4	0.4	0.4	-0.5	-0.5
Delay disc. indifference point, 4s delay	0.5	0.5	1.6	-0.5	-0.0	0.5	0.7	-1.3	-0.6	-0.8	0.8	0.8
Delay disc. indifference point, 8s delay	0.5	0.5	1.0	-0.3	-0.1	0.6	0.8	-1.0	-0.7	-0.8	0.8	0.8
Indifference point function ln k	2.2	3.1	8.1	2.8	2.6	-2.2	-1.4	1.6	1.2	1.1	-1.1	-0.6
Indifference point function log k	2.2	3.1	8.1	2.8	2.6	-2.2	-1.4	1.6	1.2	1.1	-1.1	-0.6
Patch foraging total patch changes 0 sec	0.2	0.3	1.0	1.0	0.3	-0.6	-0.6	0.1	0.5	0.4	-0.5	-0.4
Patch foraging total patch changes 12 sec	1.0	1.3	3.4	-1.7	-1.8	1.5	0.8	-1.2	-0.7	-0.6	0.7	0.3
Patch foraging total patch changes 18 sec	0.3	0.3	1.0	-0.5	-0.7	0.6	0.5	-1.0	-0.5	-0.5	0.4	0.4
Patch foraging total patch changes 24 sec	0.2	0.3	1.2	-0.8	-1.1	0.5	-0.0	0.0	0.1	0.2	-0.2	-0.4
Patch foraging total patch changes 6 sec	1.0	1.4	2.2	-0.9	-1.1	1.4	1.2	-1.5	-1.2	-1.2	1.1	1.0
Patch foraging time to switch 0 sec	3.4	5.3	6.6	-2.4	-1.3	2.4	2.6	-2.2	-2.4	-2.4	2.5	2.3
Patch foraging water rate 0 sec	6.3	10.2	12.8	3.6	2.5	-3.6	-3.4	2.9	3.2	3.2	-3.2	-2.9
Patch foraging water rate 12 sec	8.2	12.6	16.5	4.0	3.0	-4.1	-3.7	3.4	3.5	3.5	-3.5	-3.1
Patch foraging water rate 18 sec	1.5	2.0	3.2	1.8	1.5	-1.8	-1.5	1.3	1.4	1.2	-1.3	-1.1
Patch foraging water rate 24 sec	4.0	5.6	6.7	2.4	1.5	-2.6	-2.6	2.3	2.5	2.4	-2.6	-2.3
Patch foraging water rate 6 sec	3.3	4.8	5.9	2.1	1.2	-2.3	-2.4	2.4	2.4	2.2	-2.3	-2.2
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	1.2	-0.4	-0.2	0.8	1.1	-0.9	-1.1	-1.1	1.0	1.1
Distance traveled before self-admin	0.1	0.1	0.2	-0.4	-0.3	0.4	0.5	-0.0	-0.5	-0.4	0.3	0.4
Distance traveled after self-admin	0.1	0.1	0.3	-0.1	-0.0	0.2	0.2	0.6	-0.2	-0.2	0.2	0.2
Extensor digitorum longus weight	2.3	9.1	29.7	-5.2	-5.4	3.9	1.8	-1.5	-1.1	-1.2	1.3	0.1
Bone: elastic displacement	2.8	3.2	4.7	1.1	0.1	-1.5	-2.0	1.9	2.1	2.1	-2.2	-2.2
Bone: elastic work	0.7	0.9	2.7	-0.7	-1.6	0.3	-0.6	0.7	0.8	0.8	-0.9	-1.2
Bone: endosteal estimation	0.5	1.1	3.9	1.2	2.0	-0.6	0.5	-1.0	-0.8	-0.8	0.8	1.2
Bone: endosteal perimeter	1.1	2.2	7.9	1.8	2.8	-0.8	0.7	-1.3	-1.1	-1.1	1.1	1.7
Epididymis fat weight	1.3	3.1	8.7	2.9	3.0	-2.4	-1.3	0.7	1.1	1.0	-1.0	-0.4
Delta time in closed arm before/after self-admin	0.2	0.2	0.9	-0.8	-0.9	0.4	-0.1	-0.1	0.3	0.2	-0.1	-0.5
Delta time in open arm before/after self-admin	0.0	0.0	0.2	0.3	0.4	-0.2	0.1	0.0	-0.1	-0.1	0.1	0.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.5	-0.6	-0.7	0.3	0.0	0.3	-0.0	0.0	-0.3	-0.2
Delay discount exponential model param	0.7	0.7	1.6	0.4	-0.1	-0.6	-0.9	1.3	0.8	1.0	-1.0	-1.0
Extinction: sum of active levers before priming	2.9	2.9	5.1	-2.3	-2.0	2.2	1.7	-1.1	-1.6	-1.5	1.3	1.1
Active lever presses in extinction session 6	0.6	0.6	1.3	-0.7	-1.1	0.2	-0.6	0.6	0.9	0.6	-0.5	-1.0
Bone: final force	1.1	1.7	3.8	-1.9	-1.7	1.7	1.3	-0.8	-1.1	-1.1	1.0	0.8
Bone: final moment	0.9	1.4	3.1	-1.8	-1.6	1.5	1.1	-0.7	-1.0	-1.0	0.9	0.7
Food consumed during 24 hour testing period	0.5	0.6	0.7	0.7	0.7	-0.8	-0.8	0.8	0.7	0.7	-0.8	-0.6
Glucose	0.7	1.1	3.4	0.9	1.8	-0.3	0.7	-0.9	-0.9	-0.9	0.9	1.4
Heart weight	0.4	0.6	2.3	1.5	1.5	-0.9	-0.3	0.1	0.1	0.3	-0.2	0.2
Delay discount hyperbolic model param	0.7	0.8	1.7	0.4	-0.0	-0.6	-0.9	1.3	0.8	1.0	-1.0	-1.0
Intermittent access intake day 1-15 change	1.8	1.8	2.6	1.6	1.5	-1.6	-1.3	1.5	1.2	1.2	-1.0	-0.9
Intermittent access intake escalation	1.1	1.1	2.1	1.4	1.5	-1.3	-0.9	1.1	0.8	0.7	-0.6	-0.5
Intermittent access intake escalation 2	0.9	0.8	1.3	1.1	1.0	-1.1	-0.9	1.1	0.8	0.8	-0.7	-0.6
Intermitt. access day 1 inactive lever presses	0.6	0.6	1.9	1.4	1.3	-1.0	-0.5	0.0	0.4	0.4	-0.3	-0.0
Intermitt. access day 15 inactive lever presses	0.6	0.6	2.4	1.4	1.5	-0.9	-0.2	0.2	0.1	0.1	-0.1	0.3
Intermitt. access escalation Index	1.9	1.7	2.9	1.7	1.7	-1.7	-1.2	0.7	1.1	1.1	-1.2	-0.8
Intermittent access day 1 total infusions	1.6	1.8	3.7	1.1	1.8	-0.2	1.1	-1.4	-1.2	-1.3	1.4	1.9
Intermittent access day 15 total infusions	2.2	2.5	9.3	2.8	3.0	-2.0	-0.6	0.5	0.4	0.3	-0.2	0.4
Intermittent access terminal intake (last 3 days)	1.3	1.4	6.0	2.0	2.4	-1.4	-0.1	-0.1	-0.1	-0.2	0.2	0.8
Intermittent access total infusions	0.9	1.0	3.7	1.4	1.9	-0.8	0.3	-0.7	-0.4	-0.5	0.6	1.1
Intermittent access day 1 locomotion	1.5	1.5	3.2	0.3	0.9	0.3	1.2	-1.8	-1.2	-1.3	1.5	1.7
Intermittent access day 15 total locomotion	1.3	1.4	5.5	1.9	2.3	-1.6	-0.5	0.1	0.4	0.3	-0.2	0.3
Intermittent access total locomotion	1.4	1.6	6.6	1.8	2.6	-1.2	0.3	-0.8	-0.4	-0.5	0.7	1.2
Intermittent access standard deviation	0.5	0.5	1.1	1.1	1.0	-1.0	-0.6	0.7	0.6	0.5	-0.4	-0.3
Left kidney weight	1.0	2.8	5.1	2.3	1.7	-2.0	-1.7	1.1	1.5	1.6	-1.7	-1.3
Right kidney weight	1.3	3.5	4.5	2.1	1.4	-2.1	-2.1	1.4	1.9	1.9	-2.0	-1.8
Cocaine induced anxiety	0.0	0.0	0.1	0.1	0.0	-0.1	-0.1	0.4	0.1	0.0	-0.1	-0.1
Post-drug Anxiety	0.3	0.3	1.5	-0.6	-1.2	0.5	-0.2	0.6	0.2	0.2	-0.4	-0.6
Baseline Anxiety	0.5	0.5	2.1	-1.1	-1.5	0.9	0.1	0.1	0.0	0.1	-0.1	-0.4
Tail length	0.4	1.1	2.6	-0.8	-1.6	0.3	-0.7	1.4	0.8	0.9	-1.0	-1.3
Length with tail	0.6	2.2	10.0	-2.3	-3.2	1.7	0.1	0.3	0.2	0.1	-0.3	-0.9
Length without tail	0.8	1.7	6.6	-2.0	-2.6	1.7	0.6	-0.7	-0.3	-0.5	0.4	-0.2
Times rat made contact with spout	1.0	1.1	1.4	-0.9	-0.7	1.2	1.1	-1.0	-1.1	-1.1	1.1	1.0
Lifetime Intake	0.8	0.9	2.8	1.3	1.7	-0.6	0.4	-0.8	-0.5	-0.6	0.7	1.1
Liver weight, left	0.1	0.1	0.5	0.4	0.5	-0.4	-0.3	0.7	0.2	0.2	-0.3	-0.1
Liver weight, right	0.3	0.6	0.8	0.6	0.2	-0.7	-0.9	0.8	0.9	0.9	-0.8	-0.9
Locomotor activity	0.9	1.4	2.4	1.6	1.0	-1.3	-1.2	1.4	1.0	1.0	-1.0	-0.9
Locomotor testing distance	1.0	1.7	3.3	1.8	1.2	-1.4	-1.2	1.5	1.1	1.1	-1.1	-0.9
Locomotor testing rearing	0.2	0.3	1.2	1.1	1.1	-0.6	-0.0	0.2	-0.1	-0.2	0.2	0.4
Locomotion in novel chamber	2.2	2.7	9.0	2.7	3.0	-2.2	-0.9	1.1	0.7	0.7	-0.6	0.1
Locomotion in novel chamber post-restriction	1.5	1.8	4.4	2.1	2.0	-1.8	-1.1	0.9	0.9	1.0	-1.1	-0.5
Fecal boli incidents, locomotor time 1	0.0	0.0	0.1	0.1	0.1	-0.2	-0.1	-0.3	0.2	-0.1	-0.1	0.0
Change in fecal boli incidents, locomotor task	0.4	0.4	0.5	-0.6	-0.7	0.7	0.6	-0.5	-0.5	-0.6	0.7	0.5
Time >=10cm from walls, locomotor time 1	1.2	1.2	2.6	0.5	1.2	0.2	1.1	-0.9	-1.0	-1.2	1.4	1.6
Bouts of movement, locomotor time 1	0.3	0.3	0.7	-0.6	-0.8	0.2	-0.4	0.3	0.5	0.5	-0.6	-0.7
Total resting periods, locomotor time 1	0.2	0.3	0.6	-0.3	-0.5	-0.0	-0.5	0.4	0.6	0.6	-0.7	-0.7
Rest time, locomotor task time 1	2.2	2.4	3.1	1.7	1.0	-1.7	-1.6	1.7	1.7	1.4	-1.6	-1.3
Distance moved, locomotor task time 1	1.1	1.2	1.7	-0.7	-0.1	0.9	1.2	-1.3	-1.2	-1.2	1.2	1.3
Vertical activity count, locomotor time 1	0.3	0.3	1.3	0.8	1.1	-0.5	0.1	-0.2	-0.3	-0.2	0.1	0.6
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.4	0.5	0.3	-0.5	-0.5	0.2	0.7	0.4	-0.3	-0.4
Bouts of movement, locomotor time 2	0.2	0.2	0.7	-0.7	-0.8	0.6	0.2	-0.6	0.0	-0.0	0.1	-0.1
Total resting periods, locomotor time 2	0.1	0.1	0.6	-0.5	-0.5	0.5	0.3	-0.7	-0.1	-0.1	0.2	0.1
Rest time, locomotor task time 2	0.5	0.6	2.2	1.3	1.5	-0.8	0.1	-0.1	-0.2	-0.2	-0.0	0.6
Distance moved, locomotor task time 2	0.2	0.2	0.7	-0.6	-0.8	0.3	-0.3	0.3	0.4	0.4	-0.3	-0.6
Vertical activity count, locomotor time 2	1.6	1.7	3.1	0.4	-0.3	-0.9	-1.5	1.5	1.5	1.6	-1.5	-1.7
Light reinforcement 1	0.6	1.2	1.9	1.1	1.4	-1.4	-1.1	0.8	1.0	1.0	-1.0	-0.8
Light reinforcement 2	2.0	2.6	4.7	2.1	2.2	-2.1	-1.6	1.0	1.4	1.3	-1.3	-1.0
Bone: marrow area	0.5	1.1	3.9	1.2	2.0	-0.6	0.5	-1.0	-0.8	-0.8	0.8	1.2
Bone: maximum diameter	0.1	0.3	0.4	0.5	0.5	-0.6	-0.5	0.3	0.5	0.5	-0.6	-0.4
Bone: maximum force	3.0	5.1	6.0	-2.2	-1.5	2.4	2.4	-2.3	-2.4	-2.4	2.3	2.1
Bone: maximum moment	2.5	4.3	5.0	-2.0	-1.5	2.2	2.2	-2.2	-2.2	-2.2	2.1	1.9
Mean time between licks in bursts	0.3	0.4	1.4	-0.8	-1.2	0.9	0.4	-0.1	-0.3	-0.3	0.2	0.0
Mean num. licks in bursts	0.1	0.1	0.1	-0.0	-0.3	0.3	0.3	-0.4	-0.4	-0.4	0.3	0.3
Cd content in liver	1.1	1.2	2.1	1.5	1.4	-1.4	-1.1	0.7	0.9	1.0	-0.9	-0.7
Co content in liver	1.2	1.4	2.0	0.8	0.4	-1.1	-1.3	1.2	1.4	1.3	-1.3	-1.3
Cu content in liver	0.0	0.0	0.2	-0.3	-0.4	0.2	-0.1	-0.1	0.1	0.1	-0.1	-0.2
Fe content in liver	0.0	0.0	0.1	-0.2	-0.3	0.2	0.1	0.0	0.0	-0.0	0.1	0.0
K content in liver	2.8	2.8	3.4	-1.6	-1.1	1.8	1.8	-1.8	-1.8	-1.7	1.7	1.6
Mg content in liver	2.9	3.0	5.2	-0.8	0.2	1.3	1.9	-2.3	-2.0	-2.0	2.0	2.1
Mn content in liver	0.9	1.0	2.7	-1.6	-1.3	1.2	0.8	-1.0	-0.8	-0.6	0.6	0.5
Na content in liver	0.3	0.3	0.7	0.1	-0.1	-0.3	-0.6	0.8	0.5	0.6	-0.7	-0.7
Rb content in liver	1.2	1.5	2.6	0.7	1.3	0.1	1.1	-1.5	-1.3	-1.3	1.3	1.6
Se content in liver	0.4	0.5	1.0	0.1	0.6	0.3	0.8	-0.5	-0.9	-0.8	0.9	1.0
Sr content in liver	0.7	0.7	2.6	-1.2	-1.6	0.6	-0.2	0.6	0.5	0.4	-0.4	-0.8
Zn content in liver	0.3	0.4	1.2	-1.1	-1.1	0.8	0.4	-0.2	-0.4	-0.3	0.2	0.0
Bone: minimum diameter	0.9	1.7	3.0	0.6	1.4	0.2	1.2	-1.5	-1.4	-1.4	1.4	1.7
Time in familiar zone, hab. session 1	0.2	0.1	0.5	0.4	0.7	-0.2	0.2	-0.3	-0.3	-0.3	0.3	0.4
Time in novel zone, hab. session 1	0.0	0.0	0.1	-0.0	-0.2	0.0	-0.2	0.2	0.2	0.2	-0.1	-0.2
Total zone transitions, hab. session 1	0.4	0.6	1.3	-1.1	-0.7	0.9	0.7	-0.8	-0.6	-0.6	0.8	0.5
Total locomotion distance, hab. session 1	0.1	0.2	0.9	0.4	1.0	-0.5	-0.0	-0.1	-0.0	-0.0	0.1	0.2
Locomotion velocity, hab. session 1	0.0	0.0	0.3	0.1	0.5	-0.3	-0.0	-0.1	0.0	0.0	0.1	0.1
Time in familiar zone, hab. session 2	0.3	0.3	0.8	-0.5	-0.9	0.1	-0.4	0.6	0.5	0.5	-0.6	-0.8
Time in novel zone, hab. session 2	0.9	0.9	1.5	-0.1	0.4	0.6	1.0	-1.2	-1.1	-1.1	1.1	1.2
Total zone transitions, hab. session 2	4.9	6.3	7.8	-2.2	-1.0	2.5	2.8	-2.8	-2.7	-2.7	2.8	2.6
Total locomotion distance, hab. session 2	1.2	1.6	2.4	-0.7	0.3	0.9	1.4	-1.5	-1.4	-1.4	1.5	1.6
Locomotion velocity, hab. session 2	0.9	1.2	2.1	-0.4	0.6	0.6	1.2	-1.3	-1.3	-1.3	1.3	1.4
Novel to familiar place preference ratio	0.6	0.6	0.8	-0.6	-0.2	0.7	0.9	-0.9	-0.9	-0.9	0.9	0.9
Novelty place preference	0.5	0.5	0.7	-0.3	0.1	0.5	0.8	-0.8	-0.8	-0.8	0.8	0.9
Time in novel zone, NPP test	0.5	0.5	0.8	-0.4	0.0	0.5	0.8	-0.8	-0.8	-0.8	0.8	0.9
Total zone transitions, NPP test	1.8	2.6	3.8	-1.9	-1.0	1.7	1.7	-1.7	-1.6	-1.6	1.6	1.4
Total locomotion distance, NPP test	0.3	0.4	0.6	-0.5	0.3	0.4	0.7	-0.7	-0.7	-0.7	0.7	0.8
Locomotion velocity, NPP test	0.1	0.2	0.3	-0.4	0.3	0.2	0.5	-0.5	-0.5	-0.5	0.6	0.6
Intraocular pressure	1.4	1.9	2.6	1.1	0.7	-1.4	-1.5	1.5	1.5	1.5	-1.6	-1.4
Delta distance traveled before/after self-admin	0.0	0.0	0.3	0.1	0.0	-0.1	-0.1	0.6	0.1	0.1	-0.0	-0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.4	-0.1	-0.3	0.1	-0.1	0.6	0.2	0.1	-0.0	-0.2
Parametrial fat weight	0.5	1.0	4.6	1.4	2.2	-0.9	0.1	-0.6	-0.4	-0.3	0.4	0.8
Pavlov. Cond. lever latency	0.2	0.3	0.7	0.8	0.3	-0.5	-0.5	0.6	0.5	0.5	-0.5	-0.4
Pavlov. Cond. magazine entry latency	0.9	1.1	1.9	-0.3	0.3	0.6	1.2	-1.3	-1.2	-1.2	1.3	1.4
Pavlov. Cond. change in total contacts	0.2	0.3	0.6	0.3	0.8	-0.1	0.4	-0.6	-0.5	-0.5	0.6	0.7
Pavlov. Cond. index score	0.0	0.0	0.1	-0.0	0.3	-0.1	0.0	-0.1	-0.1	-0.1	0.2	0.1
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.2	0.3	0.1	0.3	-0.4	-0.3	-0.3	0.4	0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.5	0.0	0.2	0.3	-0.4	-0.3	-0.3	0.4	0.3
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.2	-0.3	0.4	0.2	-0.2	-0.2	-0.2	0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.2	0.9	0.5	-0.9	-1.1	1.1	1.1	1.1	-1.1	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.1	0.1	0.0	0.1	-0.2	-0.1	-0.1	0.2	0.2
Pavlov. Cond. response bias	0.0	0.0	0.1	0.0	0.2	-0.1	0.0	-0.1	-0.1	-0.1	0.1	0.1
Pavlov. Cond. lever latency	0.1	0.1	0.1	0.4	0.2	-0.3	-0.3	0.3	0.3	0.3	-0.2	-0.2
Pavlov. Cond. magazine entry latency	3.6	4.1	5.6	-2.3	-1.9	2.4	2.1	-2.0	-2.0	-2.0	1.9	1.7
Pavlov. Cond. change in total contacts	0.8	1.1	1.5	-0.9	-0.3	1.0	1.2	-1.1	-1.2	-1.2	1.1	1.2
Pavlov. Cond. index score	1.1	1.4	2.1	-1.4	-1.0	1.3	1.3	-1.1	-1.2	-1.2	1.1	1.1
Pavlov. Cond. latency score	0.9	1.1	1.6	-1.2	-0.8	1.1	1.1	-1.0	-1.1	-1.1	0.9	0.9
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.2	-0.2	-0.0	-0.2	0.2	0.2	0.2	-0.2	-0.3
Pavlov. Cond. magazine entry number	4.5	5.5	7.5	2.7	2.2	-2.7	-2.4	2.3	2.3	2.3	-2.2	-1.9
Pavlov. Cond. intertrial magazine entries	1.1	1.5	3.0	1.7	1.5	-1.5	-1.1	1.1	1.0	1.0	-1.0	-0.7
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	2.7	-1.6	-1.2	1.5	1.4	-1.3	-1.3	-1.3	1.2	1.1
Pavlov. Cond. response bias	0.7	0.9	1.4	-1.2	-0.9	1.1	0.9	-0.9	-0.9	-0.9	0.8	0.7
Time in closed arm before self-admin	0.1	0.1	0.2	0.3	0.5	-0.2	0.1	-0.2	-0.1	-0.2	0.2	0.3
Time in closed arm after self-admin	0.1	0.1	0.2	-0.2	-0.2	-0.1	-0.3	-0.1	0.4	0.3	-0.2	-0.4
Time in open arm before self-admin	0.1	0.1	0.3	-0.4	-0.6	0.3	-0.0	0.3	0.0	0.1	-0.2	-0.2
Time in open arm after self-admin	0.0	0.1	0.3	0.1	-0.1	-0.1	-0.2	0.5	0.2	0.2	-0.3	-0.2
Bone: periosteal estimation	0.0	0.1	0.4	0.4	0.6	-0.3	0.0	-0.2	-0.1	-0.1	0.0	0.2
Bone: periosteal perimeter	0.2	0.3	0.5	0.2	0.5	0.1	0.5	-0.7	-0.6	-0.6	0.5	0.7
Bone: post-yield work	6.0	8.2	13.4	-0.7	0.7	1.8	3.1	-3.5	-3.4	-3.4	3.4	3.7
Progressive ratio test 1 active lever presses	0.8	0.8	2.1	1.5	1.3	-1.2	-0.8	0.3	0.8	0.7	-0.6	-0.4
Progressive ratio test 1 breakpoint	0.9	0.9	2.0	1.4	1.2	-1.3	-0.9	0.4	0.9	0.8	-0.7	-0.5
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.5	0.7	0.7	-0.5	-0.2	-0.6	0.2	0.1	0.1	0.1
Progressive ratio test 2 active lever presses	1.2	1.3	3.7	1.9	1.9	-1.5	-0.8	0.4	0.7	0.6	-0.4	-0.2
Progressive ratio test 2 breakpoint	2.1	2.4	5.5	2.3	2.1	-2.0	-1.4	0.9	1.2	1.2	-1.0	-0.7
Progressive ratio test 2 inactive lever presses	2.3	2.6	9.5	2.8	3.1	-2.2	-0.8	0.2	0.6	0.5	-0.4	0.3
Incentive Sensitization - Responses	0.1	0.1	0.3	0.5	0.5	-0.3	-0.1	0.1	0.1	0.0	0.1	0.1
Incentive Sensitization - Breakpoint	0.2	0.2	0.6	0.7	0.8	-0.5	-0.2	0.2	0.2	0.2	-0.0	0.0
Sum of active levers in priming session hrs 5-6	2.2	2.2	3.7	0.4	-0.4	-0.9	-1.6	1.9	1.7	1.7	-1.6	-1.9
Progressive ratio	5.1	5.9	7.5	-2.3	-1.4	2.6	2.7	-2.2	-2.7	-2.6	2.5	2.5
Food seeking constrained by brief footshock	0.2	0.2	0.5	-0.7	-0.7	0.6	0.5	-0.1	-0.4	-0.4	0.4	0.3
Seeking ratio, punishment vs. effort	3.1	3.8	4.9	1.8	1.0	-2.1	-2.2	1.8	2.2	2.1	-2.0	-2.0
Retroperitoneal fat weight	2.2	7.2	20.1	4.3	4.5	-3.6	-1.9	1.5	1.5	1.5	-1.5	-0.5
Reaction time number correct	0.2	0.3	0.7	-0.5	-0.7	0.1	-0.5	0.6	0.6	0.6	-0.6	-0.8
Reaction time mean minus median	1.8	2.4	3.7	-1.9	-1.9	1.9	1.5	-1.5	-1.4	-1.4	1.3	1.1
Reaction time mean minus median AUC	0.8	1.1	3.0	-1.5	-1.7	1.4	0.8	-0.7	-0.6	-0.6	0.6	0.3
Reaction time num false alarms	0.6	0.8	1.3	0.4	-0.3	-0.5	-1.0	1.1	0.9	1.0	-1.1	-1.1
Reaction time num false alarms AUC	0.3	0.4	1.1	-0.4	-1.1	0.3	-0.4	0.7	0.4	0.6	-0.7	-0.8
Reaction time trials correct on left	0.2	0.3	0.7	-0.5	-0.7	0.1	-0.5	0.6	0.6	0.6	-0.6	-0.8
Reaction time trials on left	0.3	0.4	0.8	-0.5	-0.8	0.1	-0.5	0.6	0.6	0.6	-0.6	-0.9
Reaction time mean	0.3	0.4	0.6	-0.4	-0.0	0.5	0.7	-0.6	-0.7	-0.7	0.7	0.8
Reaction time mean AUC	0.3	0.4	0.7	-0.3	0.1	0.4	0.7	-0.7	-0.7	-0.8	0.8	0.9
Median of all reaction times	0.3	0.4	0.8	-0.1	0.4	0.2	0.7	-0.6	-0.6	-0.7	0.7	0.9
Reaction time omissions	0.8	1.1	3.4	-1.6	-1.8	1.4	0.7	-0.7	-0.5	-0.5	0.6	0.1
Reaction time false alarm rate	0.1	0.2	0.3	0.1	-0.4	-0.1	-0.4	0.6	0.3	0.5	-0.6	-0.5
Reaction time premature initiation rate	1.0	1.4	3.9	-1.9	-2.0	1.7	0.8	-0.4	-0.7	-0.6	0.7	0.2
Reaction time premature initiations	1.1	1.6	6.2	-2.2	-2.5	1.7	0.5	-0.0	-0.3	-0.2	0.3	-0.4
Std. dev. reaction times	0.6	0.9	1.3	-1.0	-1.0	1.1	1.0	-1.0	-0.9	-0.9	0.8	0.7
Reaction time trials completed	0.3	0.4	0.8	-0.5	-0.8	0.1	-0.5	0.6	0.6	0.6	-0.6	-0.9
Reaction time trials AUC	0.2	0.3	0.6	-0.4	-0.7	0.1	-0.5	0.5	0.5	0.5	-0.5	-0.8
Run reversals in cocaine runway, females	2.9	2.8	3.3	-1.7	-1.1	1.8	1.8	-1.7	-1.7	-1.7	1.7	1.6
Run reversals in cocaine runway, males	0.7	0.7	1.7	0.1	-0.5	-0.3	-0.8	1.3	0.9	0.9	-0.8	-1.0
Latency to leave start box in cocaine runway	0.8	0.9	1.6	-0.3	0.3	0.6	1.1	-1.0	-1.1	-1.1	1.1	1.3
Latency to leave start box in cocaine runway, F	0.6	0.7	1.1	-0.4	0.0	0.6	1.0	-0.8	-1.0	-1.0	0.9	1.1
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.1	0.2	-0.0	0.1	0.0	-0.1	-0.1	0.2	0.2
Std. dev. time between licks in bursts	0.6	0.8	1.6	-0.2	-0.8	-0.1	-0.9	1.0	1.0	1.0	-0.9	-1.2
Total sessions with >9 infusions	0.2	0.2	0.7	0.7	0.9	-0.4	0.0	-0.4	-0.0	-0.1	0.4	0.4
Short access day 1 total inactive lever presses	0.9	1.0	3.1	1.8	1.7	-1.3	-0.6	-0.0	0.5	0.4	-0.4	0.0
Short access day 10 total inactive lever presses	0.4	0.5	1.6	1.2	1.3	-0.9	-0.3	0.3	0.2	0.2	-0.2	0.1
Short access day 1 total infusions	0.6	0.6	1.9	1.3	1.4	-0.6	0.3	-0.6	-0.4	-0.4	0.6	0.9
Short access day 10 total infusions	2.1	2.3	4.4	-0.1	0.6	0.7	1.6	-1.9	-1.7	-1.7	1.8	2.1
Short access total infusions	0.7	0.8	1.5	0.3	0.8	0.2	0.9	-1.2	-0.9	-0.8	1.1	1.2
Short access day 1 locomotion	0.5	0.6	1.5	0.8	1.2	-0.4	0.4	-0.9	-0.5	-0.5	0.7	0.9
Short access day 10 total locomotion	0.4	0.4	1.1	0.3	0.7	-0.1	0.5	-1.0	-0.5	-0.6	0.8	0.9
Short access total locomotion	0.5	0.5	1.7	0.2	0.7	0.1	0.6	-1.3	-0.6	-0.5	0.9	0.9
One hour access (0.3 mA shock)	2.9	3.4	9.9	3.2	3.1	-2.4	-1.2	0.8	1.0	0.9	-0.8	-0.2
Compulsive drug intake	1.0	1.0	4.9	-1.5	-2.2	1.2	0.1	-0.1	0.0	0.1	-0.1	-0.6
One hour access (shock baseline)	3.6	4.2	12.3	3.4	3.5	-2.8	-1.4	0.9	1.2	1.1	-1.0	-0.3
Social response proportion	1.3	1.4	1.9	-1.2	-1.1	1.4	1.2	-1.3	-1.1	-1.1	1.2	1.0
Social responses	0.2	0.2	0.8	-0.7	-0.9	0.5	0.0	-0.3	0.1	0.1	0.1	-0.3
Social time	0.4	0.5	1.2	-1.0	-1.1	0.9	0.5	-0.8	-0.4	-0.5	0.5	0.2
Soleus weight	3.3	9.6	16.1	4.0	3.7	-3.9	-3.0	2.5	2.8	2.7	-2.6	-2.0
Bone: stiffness	2.9	4.6	5.6	-2.0	-1.1	2.2	2.4	-2.3	-2.3	-2.3	2.2	2.2
Tibialis anterior weight	2.2	7.4	32.4	-4.7	-5.7	2.8	0.1	0.0	0.6	0.6	-0.5	-1.8
Time to tail flick, vehicle, before self-admin	2.4	2.4	3.6	-1.2	-0.5	1.5	1.9	-1.3	-1.9	-1.8	1.5	1.9
Time to tail flick, vehicle, after self-admin	1.9	2.1	3.6	-1.9	-1.7	1.8	1.3	-1.6	-1.1	-1.1	1.3	0.8
Time to tail flick, test, before self-admin	1.6	1.6	2.5	-0.6	0.2	0.9	1.4	-1.6	-1.4	-1.4	1.5	1.6
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.4	-0.2	0.1	0.0	0.3	-0.0	-0.0	-0.1	-0.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.1	-1.0	-1.0	0.8	0.2	-1.1	-0.1	-0.1	0.4	-0.1
Delta time to tail flick, test, before/after SA	2.0	1.8	3.4	-0.1	-0.8	-0.5	-1.4	1.8	1.5	1.5	-1.7	-1.8
Tibia length	0.5	1.3	2.4	0.1	-0.6	-0.6	-1.2	1.2	1.3	1.3	-1.4	-1.5
Ambulatory time before self-admin	0.2	0.2	0.4	-0.4	-0.1	0.4	0.6	-0.1	-0.7	-0.6	0.3	0.6
Ambulatory time after self-admin	0.4	0.4	1.1	0.3	0.7	0.1	0.7	-0.1	-0.8	-0.8	0.7	1.0
Bone: tissue strength	0.1	0.1	0.4	0.2	0.4	-0.0	0.3	-0.6	-0.3	-0.3	0.3	0.4
Total heroin consumption	1.7	2.0	5.6	-2.2	-2.4	1.9	1.0	-1.0	-0.8	-0.8	0.7	0.3
Bone: trabecular number	2.5	3.9	5.5	-1.3	-0.6	1.8	2.3	-1.7	-2.3	-2.3	2.2	2.3
Bone: trabecular spacing	0.8	1.0	1.5	0.5	0.5	-1.0	-1.2	0.4	1.2	1.2	-1.1	-1.2
Bone: trabecular thickness	0.9	1.0	2.2	0.4	0.7	0.4	1.1	-0.5	-1.3	-1.3	1.2	1.5
Bone: trabecular tissue density	4.5	6.4	10.1	3.1	3.0	-3.2	-2.5	2.0	2.3	2.3	-2.2	-1.8
Water consumed over 24 hours	0.7	0.9	1.2	-1.1	-0.8	1.1	1.0	-0.8	-0.9	-0.9	0.9	0.8
Number of responses in last shaping day	0.3	0.4	0.7	0.9	0.8	-0.8	-0.6	0.1	0.6	0.6	-0.4	-0.4