Hub : Genes

Wdr72

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Wdr72	0.06	0.04	1.5e-03	0.05	0.03	0.03	0.04	1.1e-03	6.1e-03	1.5e-02	2.6e-03
2	NAcc	gene expression	Wdr72	0.06	0.03	2.8e-08	0.08	0.07	0.07	0.07	3.8e-09	1.7e-08	4.0e-08	6.8e-09
3	Eye	intron excision ratio	chr8_74941354_75012285	0.63	0.3	8.4e-03	0.03	-0.02	0.07	0.02	1.2e-01	7.2e-01	3.3e-02	1.5e-01
4	PL	gene expression	Wdr72	0.09	0.04	2.5e-13	0.12	0.12	0.12	0.13	1.2e-13	2.4e-13	4.0e-13	4.3e-14
5	Brain	gene expression	Wdr72	0.06	0.04	7.3e-04	0.01	0.03	0.02	0.03	2.0e-02	1.5e-03	3.7e-03	1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.2	0.4	1.0	0.5	1.0	-0.5	-0.5	-0.5
Area under the delay curve	0.1	0.1	0.4	-0.0	0.1	-0.0	0.6	-0.1
BMI with tail	4.9	15.7	20.9	-4.3	-4.1	3.5	4.6	3.2
BMI without tail	1.9	3.9	8.1	-1.4	-1.3	0.7	2.7	2.8
Body weight	2.6	10.7	14.6	-3.5	-3.3	3.1	3.8	2.5
Weight adjusted by age	4.4	4.9	7.5	-2.4	-2.5	2.1	2.7	1.1
Bone surface	0.1	0.3	0.7	-0.4	0.1	0.6	0.8	0.1
Bone volume	0.1	0.1	0.3	-0.3	0.1	0.4	0.5	0.1
Breakpoint value in progressive ratio session	0.1	0.1	0.2	-0.2	-0.3	0.4	0.4	0.3
Number of licking bursts	2.6	3.1	6.4	1.7	1.6	-1.4	-1.1	-2.5
Context. condit. distance diff. score	0.3	0.3	1.0	0.2	0.4	0.2	-0.6	-1.0
Locomotion velocity, session 1	0.3	0.4	0.8	-0.3	-0.2	0.6	0.7	0.9
Locomotion distance, session 1	0.9	1.1	2.2	1.4	1.5	-1.1	-0.5	0.0
Locomotion velocity, session 2	0.1	0.1	0.1	0.3	0.4	-0.1	0.3	0.4
Locomotion distance, session 2	0.5	0.6	2.2	0.4	0.4	-0.1	0.8	1.5
Locomotion velocity, session 3	0.2	0.2	0.5	0.7	0.4	-0.2	0.1	0.6
Locomotion distance, session 3	2.4	2.6	4.6	2.2	1.9	-1.7	-1.3	0.0
Stereotopy head waving bouts, day 3	1.3	1.5	2.7	-1.6	-1.6	1.5	0.5	0.1
Stereotopy head waving duration, day 3	1.6	1.9	3.7	-1.9	-1.9	1.3	0.5	0.2
Locomotion velocity, session 7	0.6	0.6	1.0	0.9	0.9	-1.0	-0.8	0.0
Locomotion distance, session 7	0.9	1.2	2.1	1.3	1.2	-1.5	-0.6	-0.2
Stereotopy head waving bouts, day 7	0.4	0.5	0.7	-0.7	-0.6	0.9	0.5	0.7
Stereotopy head waving duration, day 7	0.6	0.7	0.8	-0.9	-0.7	0.9	0.8	0.9
Locomotion velocity, session 8	0.3	0.4	0.7	-0.1	-0.1	0.8	0.7	0.9
Locomotion distance, session 8	0.4	0.5	1.3	1.0	1.1	-0.5	-0.1	-0.0
Degree of sensitization distance	0.2	0.2	0.9	-0.1	0.0	-0.4	-0.1	-0.9
Degree of sensitization stereotypy	0.3	0.3	0.5	-0.4	-0.4	0.7	0.5	0.7
Conditioned locomotion	0.1	0.1	0.5	0.2	0.3	-0.7	-0.0	-0.1
Cocaine response after cond. corrected	5.2	5.9	8.2	-2.9	-2.8	2.6	2.2	1.2
Cocaine response after cond. not corrected	4.2	4.7	7.0	-2.6	-2.7	2.5	1.8	0.3
Cocaine response before conditioning	1.0	1.2	3.7	0.9	0.7	-0.7	-0.7	-1.9
Saline control response	0.2	0.3	0.9	0.0	0.2	-0.0	-0.6	-1.0
Bone: connectivity density	1.6	2.6	4.6	1.8	2.2	-1.6	-1.3	-0.8
Bone: cortical apparent density	0.4	0.6	1.6	0.7	0.8	-0.2	-1.3	0.3
Bone: cortical area	0.3	0.5	1.0	-1.0	-0.7	1.0	-0.0	-0.5
Bone: cortical porosity	0.7	0.8	2.3	0.6	0.5	-0.5	-0.9	-1.5
Bone: cortical porosity	1.1	1.1	2.6	0.8	0.8	-0.8	-1.1	-1.6
Bone: cortical thickness	0.7	1.1	3.3	0.5	0.8	-0.5	-1.8	-1.0
Bone: cortical thickness	0.3	0.4	1.1	-0.0	0.2	0.1	-0.9	-1.1
Bone: cortical tissue density	0.4	0.5	1.5	0.7	0.8	-0.2	-1.2	0.3
Condit. Reinf. active minus inactive responses	0.6	0.7	1.4	1.2	1.1	-0.5	-0.1	0.7
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.8	-0.2	-0.3	0.9	-0.2	-0.1
Condit. Reinf. active responses	0.9	1.1	1.8	1.4	1.3	-0.8	0.3	1.0
Condit. Reinf. inactive responses	1.2	1.5	2.3	1.4	1.5	-1.5	0.4	0.7
Incentive salience index mean	0.2	0.3	0.6	0.8	0.8	-0.3	0.4	-0.0
Condit. Reinf. lever presses	0.3	0.4	0.8	0.4	0.6	-0.4	0.5	-0.9
Condit. Reinf. active minus inactive responses	1.8	2.3	4.6	-1.5	-1.4	2.1	1.3	1.1
Condit. Reinf. active-inactive response ratio	1.8	1.8	3.4	-1.6	-1.3	1.9	0.8	0.9
Condit. Reinf. active responses	0.7	0.9	2.5	-0.7	-0.6	1.6	1.0	0.4
Condit. Reinf. inactive responses	0.9	1.1	2.2	1.5	1.2	-0.5	-0.5	-1.1
Condit. Reinf. lever presses	0.8	1.1	4.2	0.3	0.3	0.2	-0.9	-2.1
Condit. Reinf. lever reinforcers received	0.5	0.6	2.2	-0.5	-0.5	1.5	0.7	0.2
Conditioned reinforcement - actives	0.0	0.0	0.1	-0.0	0.1	-0.2	0.1	-0.3
Conditioned reinforcement - inactives	0.1	0.1	0.3	0.4	0.0	-0.1	-0.5	-0.3
Conditioned locomotion	0.1	0.1	0.3	0.1	0.2	-0.3	-0.5	-0.4
Patch foraging indifference point 0 sec	0.1	0.1	0.3	-0.2	-0.1	0.4	0.5	0.6
Patch foraging indifference point AUC	0.8	0.9	1.9	1.0	1.3	-1.4	-0.1	-0.2
Delay disc. indifference point, 0s delay	1.4	1.6	2.7	1.5	1.6	-1.7	-0.1	0.4
Delay disc. indifference point, 16s delay	0.2	0.2	0.3	0.1	0.4	-0.3	-0.6	-0.5
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.4	0.5	-0.3	0.0	-0.3
Delay disc. indifference point, 24s delay	0.6	0.5	0.8	0.7	0.9	-0.8	-0.8	-0.5
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	0.1	0.3	-0.3	0.4	0.1
Delay disc. indifference point, 8s delay	0.7	0.7	2.3	-0.6	-0.6	0.6	1.5	0.2
Indifference point function ln k	1.6	2.3	4.1	-1.8	-1.8	2.0	0.9	0.5
Indifference point function log k	1.6	2.3	4.1	-1.8	-1.8	2.0	0.9	0.5
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	-0.4	-0.2	0.5	0.6	0.6
Patch foraging total patch changes 12 sec	0.6	0.8	1.8	1.0	1.4	-0.9	-0.7	-0.0
Patch foraging total patch changes 18 sec	0.2	0.2	0.5	0.3	0.7	-0.4	-0.3	-0.6
Patch foraging total patch changes 24 sec	0.8	0.9	1.6	0.8	1.1	-1.0	0.4	1.3
Patch foraging total patch changes 6 sec	0.6	0.9	2.7	0.7	0.8	-0.8	0.5	1.6
Patch foraging time to switch 0 sec	0.3	0.4	1.1	0.7	0.4	-0.4	-1.0	-0.3
Patch foraging water rate 0 sec	1.6	2.6	3.2	-1.8	-1.7	1.7	1.8	1.1
Patch foraging water rate 12 sec	1.6	2.4	3.5	-1.6	-1.4	1.9	1.6	1.3
Patch foraging water rate 18 sec	0.2	0.3	1.3	-0.1	-0.2	0.2	0.2	1.1
Patch foraging water rate 24 sec	0.4	0.6	1.3	1.1	0.9	-0.6	-0.7	-0.1
Patch foraging water rate 6 sec	0.1	0.2	0.6	-0.6	-0.2	0.3	0.8	0.1
Seeking ratio, delayed vs. immediate footshock	3.4	4.0	7.0	-2.0	-1.9	2.0	2.6	1.2
Distance traveled before self-admin	1.2	1.3	2.4	-1.0	-1.5	1.5	0.8	0.2
Distance traveled after self-admin	3.6	4.0	5.4	-2.3	-2.3	2.3	1.9	0.6
Extensor digitorum longus weight	6.5	25.6	29.7	-5.1	-5.2	4.7	5.5	4.8
Bone: elastic displacement	0.0	0.0	0.1	-0.1	0.1	-0.0	0.1	0.3
Bone: elastic work	0.0	0.0	0.1	-0.3	-0.0	0.2	-0.3	-0.1
Bone: endosteal estimation	3.1	6.8	10.2	-2.9	-2.8	2.5	3.2	1.2
Bone: endosteal perimeter	2.4	4.9	6.9	-2.4	-2.4	2.2	2.6	1.1
Epididymis fat weight	0.6	1.5	2.5	1.3	1.5	-1.6	-0.9	0.6
Delta time in closed arm before/after self-admin	0.3	0.3	0.7	-0.2	-0.4	0.4	-0.6	-0.8
Delta time in open arm before/after self-admin	1.2	1.1	1.8	1.2	1.1	-1.1	-1.3	0.1
Diff in mean of infusions in LGA sessions	2.4	2.6	4.5	-1.6	-2.1	1.9	1.5	-0.3
Delay discount exponential model param	0.1	0.1	0.4	0.1	-0.1	0.0	-0.7	0.0
Extinction: sum of active levers before priming	1.0	1.0	1.6	0.9	0.8	-0.8	-1.3	-1.2
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.1	-0.4	0.3	0.4	0.3
Bone: final force	0.7	1.1	1.8	-1.3	-1.1	1.0	1.1	0.6
Bone: final moment	0.5	0.8	1.6	-1.3	-1.0	0.9	0.7	0.4
Food consumed during 24 hour testing period	2.4	2.9	5.0	-1.9	-1.8	2.2	1.2	-1.0
Glucose	1.0	1.5	3.1	-1.2	-1.0	0.9	0.9	1.8
Heart weight	0.0	0.0	0.1	0.2	0.2	-0.2	-0.1	0.2
Delay discount hyperbolic model param	0.1	0.1	0.3	0.1	-0.1	0.0	-0.6	0.1
Intermittent access intake day 1-15 change	1.0	1.0	1.7	1.1	1.3	-1.3	-0.5	-0.1
Intermittent access intake escalation	0.3	0.3	0.6	0.6	0.8	-0.8	0.0	-0.2
Intermittent access intake escalation 2	0.1	0.1	0.5	-0.1	0.2	-0.1	0.7	0.1
Intermitt. access day 1 inactive lever presses	0.6	0.6	2.1	0.2	-0.2	0.5	-0.9	-1.4
Intermitt. access day 15 inactive lever presses	0.6	0.6	1.0	0.8	0.5	-0.7	-1.0	-0.8
Intermitt. access escalation Index	1.0	0.9	1.7	-1.0	-1.0	1.3	1.0	0.1
Intermittent access day 1 total infusions	0.2	0.3	0.8	0.0	-0.3	0.1	-0.9	-0.6
Intermittent access day 15 total infusions	0.2	0.2	0.4	0.3	0.4	-0.4	-0.6	-0.3
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.2	-0.1	-0.0	-0.1	-0.3
Intermittent access total infusions	0.2	0.2	0.7	-0.2	-0.2	-0.0	-0.6	-0.9
Intermittent access day 1 locomotion	0.3	0.3	1.0	0.0	-0.3	0.4	-1.0	-0.4
Intermittent access day 15 total locomotion	0.1	0.1	0.5	0.0	-0.1	0.3	-0.7	-0.2
Intermittent access total locomotion	0.2	0.2	0.5	-0.4	-0.7	0.7	-0.2	-0.0
Intermittent access standard deviation	0.5	0.5	1.6	0.5	0.6	-0.6	-0.3	-1.3
Left kidney weight	0.7	2.0	2.9	-1.7	-1.6	1.2	1.7	0.8
Right kidney weight	0.5	1.4	2.4	-1.2	-1.1	0.8	1.5	1.2
Cocaine induced anxiety	0.4	0.5	0.8	0.6	0.8	-0.9	-0.3	-0.7
Post-drug Anxiety	2.0	2.3	3.7	1.7	1.9	-1.9	-1.1	-0.3
Baseline Anxiety	0.8	0.8	1.1	1.1	0.9	-0.9	-0.8	0.8
Tail length	0.3	0.8	1.5	1.2	1.0	-1.1	0.0	0.7
Length with tail	0.1	0.2	0.5	-0.2	-0.3	0.5	0.7	0.3
Length without tail	1.8	4.0	6.8	-2.3	-2.4	2.6	1.3	-0.6
Times rat made contact with spout	0.7	0.8	2.8	0.5	0.6	-0.6	-0.5	-1.7
Lifetime Intake	0.2	0.3	0.7	0.0	0.1	-0.3	-0.8	-0.8
Liver weight, left	1.0	1.6	2.3	-1.3	-1.2	1.5	1.5	0.8
Liver weight, right	2.5	4.1	6.4	-1.6	-1.6	1.9	2.4	2.5
Locomotor activity	2.8	4.4	6.1	-2.5	-2.1	2.2	2.1	1.5
Locomotor testing distance	1.0	1.7	3.2	-1.8	-1.3	1.2	1.3	0.6
Locomotor testing rearing	0.3	0.4	0.7	-0.9	-0.5	0.8	0.6	0.6
Locomotion in novel chamber	0.4	0.5	1.0	0.2	0.6	-0.8	-1.0	-0.7
Locomotion in novel chamber post-restriction	0.1	0.1	0.3	0.6	0.2	-0.3	-0.1	0.2
Fecal boli incidents, locomotor time 1	0.2	0.2	0.9	0.3	0.1	0.2	-0.1	-0.9
Change in fecal boli incidents, locomotor task	2.1	2.0	3.0	-1.7	-1.7	1.6	1.0	0.8
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.8	-0.6	-0.5	0.2	0.9	-0.1
Bouts of movement, locomotor time 1	0.3	0.4	0.5	-0.5	-0.7	0.7	0.6	0.5
Total resting periods, locomotor time 1	0.2	0.3	0.6	-0.3	-0.7	0.8	0.3	0.2
Rest time, locomotor task time 1	0.3	0.3	0.9	0.2	0.1	0.1	-0.9	-0.8
Distance moved, locomotor task time 1	0.6	0.6	0.9	0.7	0.9	-1.0	0.2	0.9
Vertical activity count, locomotor time 1	0.2	0.2	0.4	0.3	0.4	-0.6	0.3	0.5
Time >=10cm from walls, locomotor time 2	0.3	0.3	1.1	0.0	0.3	-0.4	-0.0	-1.1
Bouts of movement, locomotor time 2	0.6	0.7	2.0	-0.4	0.6	-0.6	0.8	1.4
Total resting periods, locomotor time 2	0.5	0.5	1.5	-0.4	0.5	-0.4	0.7	1.2
Rest time, locomotor task time 2	0.5	0.6	1.8	0.2	0.3	-0.2	-1.4	-1.0
Distance moved, locomotor task time 2	0.5	0.6	1.3	0.8	0.6	-0.7	0.4	1.1
Vertical activity count, locomotor time 2	1.0	1.0	1.8	1.2	1.2	-1.4	-0.5	-0.6
Light reinforcement 1	1.0	1.8	4.5	-1.1	-0.8	1.2	2.1	1.1
Light reinforcement 2	0.7	0.9	3.5	-0.1	0.3	-0.2	-1.0	-1.9
Bone: marrow area	3.2	7.0	10.3	-3.0	-2.9	2.5	3.2	1.1
Bone: maximum diameter	1.9	3.5	4.8	-2.2	-2.0	2.1	2.0	0.2
Bone: maximum force	1.0	1.8	2.6	-1.5	-1.3	1.6	1.4	0.6
Bone: maximum moment	0.8	1.4	2.2	-1.5	-1.2	1.5	1.0	0.3
Mean time between licks in bursts	0.9	1.3	2.0	1.0	0.8	-1.1	-1.2	-1.4
Mean num. licks in bursts	1.4	1.7	2.7	-1.6	-1.4	1.2	0.8	1.4
Cd content in liver	0.7	0.8	1.7	1.3	0.9	-1.2	0.0	0.5
Co content in liver	0.4	0.5	1.0	0.8	0.7	-1.0	-0.4	-0.3
Cu content in liver	0.6	0.8	1.2	-0.9	-1.1	0.6	0.9	0.8
Fe content in liver	1.3	1.5	2.2	1.4	1.5	-1.5	-0.9	-0.8
K content in liver	0.4	0.4	0.6	-0.6	-0.3	0.5	0.7	0.7
Mg content in liver	2.3	2.3	2.9	-1.5	-1.6	1.6	1.7	1.2
Mn content in liver	1.0	1.1	2.0	-0.9	-0.5	1.4	-0.6	-1.4
Na content in liver	0.7	0.7	1.5	-1.1	-0.6	0.4	1.2	0.6
Rb content in liver	2.1	2.6	4.3	-1.1	-1.5	1.4	1.8	2.1
Se content in liver	1.2	1.4	2.4	1.3	1.2	-0.9	-1.5	-1.0
Sr content in liver	0.8	0.7	1.1	0.8	0.9	-0.9	-0.5	-1.0
Zn content in liver	0.2	0.2	0.5	0.1	0.3	-0.4	-0.4	-0.7
Bone: minimum diameter	0.2	0.3	0.6	-0.8	-0.6	0.6	0.2	-0.5
Time in familiar zone, hab. session 1	0.2	0.2	0.5	0.2	0.1	0.5	-0.0	-0.7
Time in novel zone, hab. session 1	0.1	0.1	0.4	0.1	0.2	-0.4	-0.6	0.2
Total zone transitions, hab. session 1	1.8	2.6	4.7	2.2	2.0	-1.6	-1.0	0.7
Total locomotion distance, hab. session 1	1.0	1.4	2.1	1.5	1.4	-1.0	-0.6	1.3
Locomotion velocity, hab. session 1	0.5	0.6	1.3	0.9	0.8	-0.6	-0.1	1.1
Time in familiar zone, hab. session 2	0.2	0.2	0.5	0.5	0.3	0.0	-0.6	-0.7
Time in novel zone, hab. session 2	0.4	0.4	0.9	-0.9	-0.8	0.7	0.4	0.3
Total zone transitions, hab. session 2	1.6	2.0	3.1	1.6	1.8	-1.7	0.1	1.2
Total locomotion distance, hab. session 2	1.2	1.6	2.4	1.4	1.5	-1.5	0.1	1.1
Locomotion velocity, hab. session 2	1.0	1.4	2.3	1.3	1.4	-1.5	-0.0	0.9
Novel to familiar place preference ratio	1.8	1.8	2.3	-1.5	-1.5	1.3	1.4	1.0
Novelty place preference	2.2	2.3	2.9	-1.7	-1.7	1.5	1.6	0.9
Time in novel zone, NPP test	2.8	2.9	3.8	-1.9	-2.0	1.8	1.6	0.9
Total zone transitions, NPP test	0.8	1.2	2.3	1.2	1.5	-1.2	-0.1	0.8
Total locomotion distance, NPP test	0.9	1.2	2.2	1.2	1.5	-1.2	0.1	0.9
Locomotion velocity, NPP test	1.4	2.0	3.7	1.7	1.9	-1.7	-0.2	0.8
Intraocular pressure	0.2	0.3	0.5	0.7	0.7	-0.1	-0.6	0.2
Delta distance traveled before/after self-admin	1.9	2.1	3.4	-1.8	-1.4	1.5	1.5	0.7
Delta ambulatory time before/after self-admin	1.2	1.3	2.8	-1.7	-1.1	1.2	1.1	0.0
Parametrial fat weight	0.9	1.7	3.2	1.8	1.4	-1.4	-1.1	0.2
Pavlov. Cond. lever latency	0.7	0.8	1.1	-0.9	-1.1	1.0	-0.3	1.0
Pavlov. Cond. magazine entry latency	2.4	3.1	3.9	2.0	2.0	-1.6	-1.2	-2.0
Pavlov. Cond. change in total contacts	0.4	0.4	0.8	0.7	0.9	-0.4	-0.1	-0.8
Pavlov. Cond. index score	1.9	2.5	3.6	1.8	1.9	-1.6	-0.6	-1.5
Pavlov. Cond. latency score	1.9	2.4	3.6	1.8	1.9	-1.6	-0.5	-1.5
Pavlov. Cond. lever contacts	0.6	0.7	1.0	0.9	1.0	-0.9	0.2	-0.9
Pavlov. Cond. magazine entry number	2.2	2.7	3.9	-2.0	-1.9	1.7	1.1	1.5
Pavlov. Cond. intertrial magazine entries	0.6	0.7	2.7	0.3	0.4	-0.0	0.6	1.6
Pavlov. Cond. lever-magazine prob. diff.	1.6	1.9	2.9	1.6	1.7	-1.5	-0.3	-1.4
Pavlov. Cond. response bias	1.0	1.2	1.9	1.4	1.4	-1.2	-0.4	-0.9
Pavlov. Cond. lever latency	0.6	0.9	2.3	-1.0	-0.8	0.3	0.6	1.5
Pavlov. Cond. magazine entry latency	5.4	6.3	8.1	2.5	2.3	-2.3	-2.8	-2.5
Pavlov. Cond. change in total contacts	1.2	1.7	2.3	1.5	1.3	-0.9	-1.2	-1.4
Pavlov. Cond. index score	2.4	3.1	4.5	1.8	1.7	-1.5	-1.6	-2.1
Pavlov. Cond. latency score	2.0	2.5	4.5	1.6	1.4	-1.2	-1.5	-2.1
Pavlov. Cond. lever contacts	0.5	0.7	2.3	0.8	0.6	-0.1	-0.4	-1.5
Pavlov. Cond. magazine entry number	3.7	4.6	5.1	-2.3	-2.1	2.0	2.2	2.0
Pavlov. Cond. intertrial magazine entries	0.8	1.1	1.6	-0.9	-1.1	1.3	1.2	0.6
Pavlov. Cond. lever-magazine prob. diff.	2.8	3.6	5.4	2.0	1.8	-1.6	-1.7	-2.3
Pavlov. Cond. response bias	1.6	2.2	2.9	1.7	1.5	-1.1	-1.3	-1.7
Time in closed arm before self-admin	0.1	0.1	0.2	0.0	0.4	-0.4	0.2	-0.4
Time in closed arm after self-admin	0.1	0.1	0.2	-0.1	0.1	-0.1	-0.2	-0.5
Time in open arm before self-admin	2.6	2.8	5.3	-1.7	-2.0	2.3	1.3	0.3
Time in open arm after self-admin	0.3	0.3	0.8	-0.4	-0.9	0.8	-0.1	0.2
Bone: periosteal estimation	2.1	4.3	6.1	-2.5	-2.2	2.2	2.3	0.8
Bone: periosteal perimeter	1.9	3.2	4.2	-2.0	-1.9	2.0	1.8	0.9
Bone: post-yield work	0.2	0.3	1.2	-0.3	-0.1	0.3	1.1	-0.2
Progressive ratio test 1 active lever presses	0.2	0.2	0.6	-0.8	-0.5	0.5	0.2	-0.1
Progressive ratio test 1 breakpoint	0.2	0.2	0.3	-0.6	-0.4	0.5	0.0	-0.4
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.9	0.1	-0.2	0.3	-0.7	-1.0
Progressive ratio test 2 active lever presses	0.6	0.6	0.9	-1.0	-0.8	0.7	0.7	0.8
Progressive ratio test 2 breakpoint	0.5	0.6	0.8	-0.9	-0.8	0.7	0.6	0.8
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.9	0.6	0.3	-0.5	-1.4	-1.1
Incentive Sensitization - Responses	1.0	1.1	1.2	-1.0	-1.1	1.0	1.1	0.9
Incentive Sensitization - Breakpoint	0.7	0.8	1.0	-0.8	-0.9	0.7	0.9	1.0
Sum of active levers in priming session hrs 5-6	0.6	0.5	0.9	-1.0	-0.8	0.8	0.5	0.3
Progressive ratio	0.1	0.1	0.2	0.0	0.0	0.4	0.2	-0.5
Food seeking constrained by brief footshock	0.3	0.3	1.4	-0.4	0.0	0.0	1.2	0.2
Seeking ratio, punishment vs. effort	0.8	1.0	1.8	-0.9	-0.7	0.3	1.3	1.3
Retroperitoneal fat weight	0.4	1.2	1.9	1.4	1.1	-1.1	-0.4	1.1
Reaction time number correct	0.4	0.5	0.9	-0.7	-0.4	0.4	0.9	1.0
Reaction time mean minus median	0.1	0.1	0.2	0.2	0.3	-0.4	-0.5	0.1
Reaction time mean minus median AUC	0.4	0.5	0.9	0.6	0.7	-0.8	-1.0	-0.5
Reaction time num false alarms	0.3	0.5	1.0	0.5	0.8	-1.0	-0.7	0.1
Reaction time num false alarms AUC	0.2	0.2	0.6	0.2	0.5	-0.8	-0.4	0.3
Reaction time trials correct on left	0.4	0.5	0.9	-0.7	-0.4	0.4	0.9	1.0
Reaction time trials on left	0.4	0.5	1.0	-0.7	-0.4	0.4	0.9	1.0
Reaction time mean	1.1	1.6	2.7	1.1	1.1	-1.2	-1.6	-1.2
Reaction time mean AUC	0.7	1.0	1.6	0.9	0.9	-0.9	-1.3	-0.7
Median of all reaction times	1.6	2.3	3.7	1.3	1.4	-1.4	-1.9	-1.4
Reaction time omissions	0.2	0.3	1.5	0.2	0.2	0.1	0.1	1.2
Reaction time false alarm rate	0.5	0.7	1.1	0.7	0.9	-1.0	-1.0	-0.3
Reaction time premature initiation rate	0.2	0.3	0.7	-0.8	-0.4	-0.2	0.7	0.4
Reaction time premature initiations	0.6	0.8	1.5	-1.2	-0.6	0.1	1.1	0.9
Std. dev. reaction times	0.8	1.1	1.8	1.1	1.0	-1.1	-1.4	-0.4
Reaction time trials completed	0.4	0.5	1.0	-0.7	-0.4	0.4	0.9	1.0
Reaction time trials AUC	0.3	0.5	0.9	-0.6	-0.4	0.4	0.9	1.0
Run reversals in cocaine runway, females	0.2	0.2	0.6	0.2	0.2	-0.2	-0.8	-0.4
Run reversals in cocaine runway, males	0.3	0.3	0.8	0.4	0.2	-0.0	0.8	0.9
Latency to leave start box in cocaine runway	1.6	1.8	3.0	-1.4	-1.7	1.4	1.3	0.7
Latency to leave start box in cocaine runway, F	0.4	0.4	0.6	-0.4	-0.8	0.6	0.8	0.5
Latency to leave start box in cocaine runway, M	1.3	1.3	2.2	-1.2	-1.5	0.9	1.0	0.8
Std. dev. time between licks in bursts	0.1	0.2	0.4	0.2	0.3	-0.3	0.4	-0.6
Total sessions with >9 infusions	0.5	0.6	1.1	-1.0	-1.1	0.8	0.2	-0.2
Short access day 1 total inactive lever presses	0.4	0.4	0.8	-0.7	-0.9	0.8	-0.1	-0.4
Short access day 10 total inactive lever presses	0.5	0.6	1.2	0.7	0.4	0.2	-1.0	-1.1
Short access day 1 total infusions	0.1	0.1	0.4	-0.2	-0.1	-0.0	-0.5	-0.7
Short access day 10 total infusions	0.3	0.3	1.0	-0.1	-0.1	-0.2	-0.8	-1.0
Short access total infusions	0.4	0.4	1.2	0.2	0.2	-0.4	-1.1	-0.8
Short access day 1 locomotion	0.3	0.3	0.6	-0.8	-0.5	0.7	0.4	0.1
Short access day 10 total locomotion	0.6	0.7	2.0	-0.7	-1.0	1.4	0.1	-0.3
Short access total locomotion	0.4	0.5	1.3	-0.2	-0.2	0.5	-0.8	-1.2
One hour access (0.3 mA shock)	0.2	0.3	0.5	-0.4	-0.7	0.6	0.1	0.6
Compulsive drug intake	0.7	0.7	1.7	-0.6	-1.2	1.3	-0.1	-0.6
One hour access (shock baseline)	0.0	0.0	0.1	-0.0	0.1	-0.3	-0.0	-0.0
Social response proportion	0.7	0.8	1.6	-1.3	-1.2	0.9	0.2	0.3
Social responses	0.2	0.2	1.0	-0.0	0.2	-0.3	-0.1	-1.0
Social time	0.6	0.7	1.2	-0.8	-1.0	1.1	0.7	0.6
Soleus weight	13.5	39.6	55.2	-6.3	-6.4	6.2	7.4	4.9
Bone: stiffness	1.6	2.6	3.5	-1.4	-1.4	1.7	1.7	1.9
Tibialis anterior weight	12.9	44.1	51.6	-7.2	-7.2	7.0	6.8	4.7
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.8	1.4	1.2	-1.3	-0.2	0.1
Time to tail flick, vehicle, after self-admin	1.6	1.7	2.6	-1.6	-1.5	1.5	1.0	-0.2
Time to tail flick, test, before self-admin	1.1	1.1	1.7	1.2	1.3	-1.3	-0.6	-0.4
Time to tail flick, test, after self-admin	2.0	2.1	3.4	1.4	1.4	-1.3	-1.1	-1.8
Delta time to tail flick, vehicle, before/after SA	1.7	1.7	2.7	-1.6	-1.6	1.6	0.7	-0.2
Delta time to tail flick, test, before/after SA	0.5	0.4	1.6	-0.4	-0.5	0.5	-0.1	-1.2
Tibia length	0.5	1.3	1.6	-1.3	-1.2	1.2	0.5	-1.2
Ambulatory time before self-admin	0.2	0.2	0.6	-0.2	-0.7	0.8	0.1	-0.0
Ambulatory time after self-admin	2.8	3.1	4.7	-2.2	-2.0	2.1	1.5	0.3
Bone: tissue strength	0.3	0.3	1.1	0.4	0.3	-0.5	-1.0	-0.2
Total heroin consumption	0.8	1.0	1.9	-0.9	-0.8	0.9	1.4	0.8
Bone: trabecular number	0.9	1.5	2.4	1.3	1.6	-1.2	-0.9	-1.0
Bone: trabecular spacing	0.3	0.4	0.6	0.6	0.3	-0.8	-0.7	0.5
Bone: trabecular thickness	0.2	0.2	0.6	-0.4	0.1	0.4	-0.4	-0.8
Bone: trabecular tissue density	6.5	9.2	13.1	-3.5	-3.6	3.1	2.3	2.4
Water consumed over 24 hours	0.4	0.5	2.6	0.1	0.1	-0.0	-0.1	-1.6
Number of responses in last shaping day	0.9	0.9	3.9	-0.5	-0.5	0.4	-0.2	-2.0