Hub : Genes

Wdr72

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Wdr72	0.06	0.04	1.8e-03	0.04	0.04	0.02	0.04	2.4e-03	2.3e-03	3.1e-02	1.9e-03
2	NAcc	gene expression	Wdr72	0.07	0.04	4.9e-11	0.08	0.07	0.08	0.08	8.7e-12	8.9e-11	1.1e-11	1.3e-11
3	pVTA	gene expression	Wdr72	0.04	0.03	3.9e-03	0.02	0.02	0.02	0.03	6.6e-03	6.2e-03	4.4e-03	3.4e-03
4	Eye	intron excision ratio	chr8_83821925_83892849	0.61	0.27	7.0e-03	-0.02	-0.02	-0	-0.02	9.3e-01	9.1e-01	3.9e-01	9.8e-01
5	IC	gene expression	Wdr72	0.06	0.04	8.1e-03	-0	0.01	-0.01	0	6.0e-01	9.4e-02	9.4e-01	3.2e-01
6	PL	gene expression	Wdr72	0.08	0.04	1.4e-12	0.12	0.12	0.12	0.12	2.3e-13	9.4e-13	4.5e-13	1.6e-13
7	Brain	gene expression	Wdr72	0.08	0.05	2.0e-04	0.04	0.03	0.04	0.03	1.4e-04	1.1e-03	2.2e-04	3.4e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	0.3	0.6	1.2	-1.1	1.1	-0.6	-1.1	-0.6	-0.6	0.0
Area under the delay curve	0.1	0.1	0.7	-0.0	-0.0	0.1	0.1	0.2	0.5	0.8
BMI with tail	5.9	20.6	28.5	4.7	-4.7	4.7	3.8	5.3	4.8	-3.3
BMI without tail	0.8	4.4	7.1	1.6	-1.6	2.3	0.8	2.7	2.6	-2.5
Body weight	2.8	12.1	17.3	3.5	-3.4	3.9	2.7	4.2	3.7	-2.5
Weight adjusted by age	1.3	3.9	5.7	2.2	-2.1	1.8	2.3	1.9	2.4	0.3
Bone surface	0.1	0.2	0.8	-0.1	0.2	0.9	0.2	0.4	0.7	-0.1
Bone volume	0.1	0.2	0.5	-0.2	0.2	0.7	-0.2	0.4	0.5	-0.3
Breakpoint value in progressive ratio session	0.1	0.2	0.8	0.2	-0.3	0.9	0.4	0.3	0.4	-0.5
Number of licking bursts	1.1	3.2	7.9	-1.7	1.9	-0.4	-1.5	-2.2	-1.1	2.8
Context. condit. distance diff. score	0.2	0.3	0.9	-0.3	0.3	0.6	-0.3	-0.4	-0.6	0.9
Locomotion velocity, session 1	0.7	0.8	3.6	0.3	-0.4	0.6	0.5	0.7	0.9	-1.9
Locomotion distance, session 1	1.2	1.5	2.5	-1.6	1.6	-1.4	-1.5	-1.0	-0.5	-0.6
Locomotion velocity, session 2	0.3	0.3	1.8	-0.4	0.4	0.3	-0.4	-0.0	0.3	-1.3
Locomotion distance, session 2	0.5	0.8	2.9	-0.6	0.6	-0.9	-0.6	0.2	0.7	-1.7
Locomotion velocity, session 3	0.1	0.1	0.4	-0.4	0.3	-0.0	-0.2	-0.3	0.2	-0.6
Locomotion distance, session 3	2.0	2.2	4.2	-2.1	1.9	-1.3	-1.5	-1.3	-1.2	-0.7
Stereotopy head waving bouts, day 3	1.0	1.2	2.8	1.7	-1.6	0.6	1.3	0.8	0.4	0.3
Stereotopy head waving duration, day 3	1.3	1.6	4.0	2.0	-2.0	0.8	1.2	0.9	0.4	0.3
Locomotion velocity, session 7	0.4	0.5	1.3	-0.7	0.6	-0.6	-1.2	-0.6	-0.7	0.0
Locomotion distance, session 7	0.6	0.8	1.9	-1.2	1.1	-0.3	-1.4	-0.7	-0.6	-0.1
Stereotopy head waving bouts, day 7	0.2	0.3	0.5	0.7	-0.6	0.1	0.7	0.4	0.7	0.2
Stereotopy head waving duration, day 7	0.2	0.3	0.5	0.6	-0.5	-0.0	0.7	0.3	0.7	0.5
Locomotion velocity, session 8	0.2	0.2	0.8	0.1	-0.2	-0.1	0.4	0.0	0.7	-0.9
Locomotion distance, session 8	0.5	0.7	1.5	-1.2	1.2	-0.4	-1.2	-0.7	-0.2	-0.1
Degree of sensitization distance	0.3	0.3	1.7	0.1	-0.0	0.2	-0.4	-0.4	-0.2	1.3
Degree of sensitization stereotypy	0.1	0.1	0.3	0.3	-0.2	0.0	0.5	0.3	0.6	-0.0
Conditioned locomotion	0.1	0.1	0.2	-0.3	0.3	-0.3	-0.4	-0.0	-0.4	0.1
Cocaine response after cond. corrected	4.1	6.1	10.1	2.7	-2.7	3.2	2.3	2.6	2.1	-1.1
Cocaine response after cond. not corrected	3.4	4.9	8.7	2.5	-2.5	3.0	2.1	2.2	1.8	-0.4
Cocaine response before conditioning	0.6	0.7	2.3	-0.7	0.6	-0.5	-0.4	-1.0	-0.4	1.5
Saline control response	0.0	0.0	0.1	0.0	0.0	0.1	0.1	-0.2	-0.4	0.3
Bone: connectivity density	2.1	3.4	5.1	-2.3	2.3	-2.1	-2.0	-1.8	-1.3	0.3
Bone: cortical apparent density	0.7	1.1	2.6	-1.0	1.0	-1.2	-1.0	-0.8	-1.6	-0.4
Bone: cortical area	0.2	0.3	0.9	0.5	-0.4	1.0	0.2	0.5	-0.4	0.2
Bone: cortical porosity	0.6	0.6	1.1	-0.7	0.6	-0.6	-0.5	-1.0	-1.0	0.8
Bone: cortical porosity	0.6	0.6	1.1	-0.7	0.6	-0.6	-0.6	-1.0	-1.0	0.8
Bone: cortical thickness	0.9	1.5	4.7	-0.9	1.0	-1.0	-1.4	-0.9	-2.2	0.2
Bone: cortical thickness	0.2	0.2	0.8	0.0	-0.0	0.1	-0.1	-0.2	-0.9	0.9
Bone: cortical tissue density	0.7	1.1	2.4	-1.0	1.0	-1.2	-1.0	-0.8	-1.6	-0.4
Condit. Reinf. active minus inactive responses	0.4	0.4	0.9	-0.9	0.7	-0.5	-0.9	-0.2	0.1	-0.7
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.5	-0.6	0.6	0.3	0.3	-0.1	0.5
Condit. Reinf. active responses	0.7	0.9	1.9	-1.2	1.3	-0.7	-1.4	-0.3	0.4	-0.7
Condit. Reinf. inactive responses	1.2	1.6	3.3	-1.6	1.8	-1.2	-1.6	-0.8	0.3	-0.7
Incentive salience index mean	0.1	0.2	0.3	-0.6	0.5	-0.3	-0.5	-0.3	0.5	0.3
Condit. Reinf. lever presses	0.3	0.4	1.7	-0.4	0.4	-0.2	-0.2	-0.6	0.5	1.3
Condit. Reinf. active minus inactive responses	1.0	1.6	2.3	1.2	-1.3	1.5	0.7	1.4	1.3	-1.3
Condit. Reinf. active-inactive response ratio	0.8	1.2	2.1	1.3	-1.3	1.4	0.7	1.2	0.8	-0.8
Condit. Reinf. active responses	0.4	0.6	1.2	0.5	-0.6	1.1	0.3	0.9	1.1	-0.7
Condit. Reinf. inactive responses	0.6	0.9	1.8	-1.3	1.2	-0.9	-0.7	-1.0	-0.4	0.8
Condit. Reinf. lever presses	0.6	0.9	4.0	-0.4	0.2	0.5	-0.4	-0.9	-0.9	2.0
Condit. Reinf. lever reinforcers received	0.3	0.4	0.7	0.3	-0.5	0.9	0.2	0.6	0.7	-0.7
Conditioned reinforcement - actives	0.2	0.6	1.3	0.7	-0.7	1.2	0.6	0.4	0.6	1.1
Conditioned reinforcement - inactives	0.1	0.2	0.6	0.5	-0.6	-0.0	0.7	0.0	0.1	0.5
Conditioned locomotion	0.1	0.1	0.6	-0.2	0.3	-0.0	-0.1	-0.0	-0.3	0.8
Patch foraging indifference point 0 sec	0.1	0.3	0.9	0.2	-0.2	0.7	0.9	0.6	0.4	-0.1
Patch foraging indifference point AUC	0.4	1.0	2.0	-1.4	1.4	-1.3	-0.9	-0.9	-0.3	0.1
Delay disc. indifference point, 0s delay	1.5	1.7	3.2	-1.8	1.8	-0.9	-1.7	-0.7	-0.2	-1.1
Delay disc. indifference point, 16s delay	0.4	0.5	1.6	-0.2	0.2	-1.0	-0.3	-0.6	-0.7	1.2
Delay disc. indifference point, 2s delay	0.1	0.2	0.3	-0.5	0.5	-0.3	-0.2	-0.3	0.0	0.6
Delay disc. indifference point, 24s delay	0.2	0.4	0.5	-0.6	0.5	-0.7	-0.6	-0.6	-0.6	0.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.3	0.3	0.4	-0.2	0.3	0.4	-0.1
Delay disc. indifference point, 8s delay	0.5	0.8	2.2	0.6	-0.6	0.9	0.7	0.8	1.5	0.8
Indifference point function ln k	0.9	2.6	4.6	2.1	-2.0	1.9	1.7	1.4	1.1	-0.0
Indifference point function log k	0.9	2.6	4.6	2.1	-2.0	1.9	1.7	1.4	1.1	-0.0
Patch foraging total patch changes 0 sec	0.1	0.3	1.0	0.3	-0.2	0.6	1.0	0.5	0.4	-0.0
Patch foraging total patch changes 12 sec	0.8	1.1	2.0	-1.4	1.4	-1.4	-0.2	-0.9	-0.9	0.1
Patch foraging total patch changes 18 sec	0.3	0.8	1.9	-0.9	1.0	-0.6	-0.3	-0.8	-0.9	1.4
Patch foraging total patch changes 24 sec	0.3	0.9	1.9	-1.3	1.4	-0.4	-0.9	0.1	0.1	-1.3
Patch foraging total patch changes 6 sec	0.6	1.0	4.0	-1.1	1.0	-0.6	-0.6	0.1	0.1	-2.0
Patch foraging time to switch 0 sec	0.1	0.3	0.8	-0.4	0.3	-0.7	-0.5	-0.6	-0.9	0.1
Patch foraging water rate 0 sec	0.7	2.8	5.2	1.6	-1.5	2.3	1.7	1.8	1.7	-0.6
Patch foraging water rate 12 sec	0.6	2.4	3.3	1.6	-1.6	1.8	1.6	1.6	1.6	-0.5
Patch foraging water rate 18 sec	0.2	0.4	1.9	0.2	-0.2	0.6	-0.3	0.7	0.2	-1.4
Patch foraging water rate 24 sec	0.3	0.4	0.7	-0.8	0.8	0.1	-0.8	-0.5	-0.4	-0.4
Patch foraging water rate 6 sec	0.3	0.5	1.5	0.5	-0.3	1.2	0.7	0.4	0.7	0.5
Seeking ratio, delayed vs. immediate footshock	2.5	3.5	5.9	1.7	-1.6	2.1	2.1	2.0	2.4	-0.6
Distance traveled before self-admin	0.4	0.8	1.4	1.0	-1.0	0.9	1.2	0.6	1.1	-0.2
Distance traveled after self-admin	2.3	4.0	5.7	2.3	-2.2	2.4	2.2	1.8	1.9	-0.5
Extensor digitorum longus weight	6.1	24.2	33.0	5.2	-5.2	3.8	4.8	5.5	5.7	-4.0
Bone: elastic displacement	0.1	0.2	0.7	-0.0	0.1	-0.3	-0.5	0.3	0.1	-0.8
Bone: elastic work	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.0	0.1	-0.2	-0.2
Bone: endosteal estimation	3.0	7.3	10.7	2.8	-2.7	3.3	2.9	2.7	3.0	0.1
Bone: endosteal perimeter	1.8	4.5	5.9	2.2	-2.2	2.3	2.3	2.2	2.4	-0.5
Epididymis fat weight	0.3	1.3	3.8	-1.0	1.0	-2.0	-1.4	-0.2	-0.4	-1.2
Delta time in closed arm before/after self-admin	0.6	0.6	1.4	-0.5	0.3	-0.8	-0.3	-0.8	-1.0	1.2
Delta time in open arm before/after self-admin	0.4	0.4	0.7	-0.7	0.7	-0.7	-0.4	-0.6	-0.8	-0.3
Diff in mean of infusions in LGA sessions	1.5	2.6	4.1	1.7	-1.9	2.0	1.7	1.2	1.5	1.0
Delay discount exponential model param	0.1	0.2	0.7	-0.0	0.1	-0.3	-0.1	-0.3	-0.6	-0.8
Extinction: sum of active levers before priming	0.2	0.4	2.0	-0.1	-0.0	-0.1	0.2	-0.6	-0.3	1.4
Active lever presses in extinction session 6	1.1	1.1	1.9	1.0	-1.0	1.4	0.9	1.0	1.2	-0.9
Bone: final force	0.6	0.9	1.9	1.1	-1.0	1.4	0.4	1.2	0.8	-0.3
Bone: final moment	0.4	0.6	1.2	1.0	-0.9	1.1	0.3	1.0	0.4	0.0
Food consumed during 24 hour testing period	1.9	3.9	9.0	1.9	-1.9	3.0	2.2	1.3	1.3	1.7
Glucose	0.5	0.8	1.2	0.8	-0.8	0.5	0.8	1.1	0.9	-1.1
Heart weight	0.2	0.4	1.0	-0.4	0.4	0.7	-0.7	0.4	0.5	-1.0
Delay discount hyperbolic model param	0.1	0.2	0.7	0.0	0.0	-0.2	-0.1	-0.2	-0.6	-0.8
Intermittent access intake day 1-15 change	0.0	0.2	0.8	0.2	-0.2	0.8	0.2	0.4	0.9	-0.1
Intermittent access intake escalation	0.0	0.2	0.8	0.2	-0.2	0.7	0.2	0.4	0.9	-0.2
Intermittent access intake escalation 2	0.6	1.0	2.2	0.8	-0.7	1.4	0.9	0.8	1.5	0.2
Intermitt. access day 1 inactive lever presses	0.1	1.1	3.2	-0.4	0.3	-0.8	-0.0	-1.2	-1.4	1.8
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.9	-0.2	0.2	-0.9	-0.2	-0.2	-0.3	-0.4
Intermitt. access escalation Index	0.2	0.5	0.7	0.7	-0.7	0.7	0.8	0.6	0.5	0.8
Intermittent access day 1 total infusions	0.1	0.3	0.9	-0.5	0.4	-0.1	-0.4	-0.7	-0.9	0.4
Intermittent access day 15 total infusions	0.0	0.0	0.1	-0.3	0.2	0.1	-0.3	-0.2	-0.2	0.1
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.7	0.4	-0.4	0.8	0.3	0.3	0.3	0.4
Intermittent access total infusions	0.3	0.3	1.5	0.1	-0.0	0.6	-0.0	-0.3	-0.4	1.2
Intermittent access day 1 locomotion	0.1	0.1	0.4	-0.1	-0.1	-0.3	0.2	-0.0	-0.6	-0.5
Intermittent access day 15 total locomotion	0.1	0.3	0.6	0.5	-0.6	0.3	0.8	0.5	-0.0	-0.6
Intermittent access total locomotion	0.7	0.8	1.3	0.9	-1.0	1.2	1.1	0.9	0.5	-0.2
Intermittent access standard deviation	0.0	0.3	0.8	0.3	-0.3	0.6	0.4	-0.0	0.4	0.9
Left kidney weight	0.5	4.1	5.6	2.3	-2.3	2.4	1.8	2.3	2.1	-0.2
Right kidney weight	0.4	3.1	4.6	1.7	-1.7	1.9	1.5	2.1	2.1	-1.2
Cocaine induced anxiety	0.1	0.4	0.9	-0.6	0.8	0.1	-0.7	-0.5	-0.5	1.0
Post-drug Anxiety	1.1	1.2	2.6	-1.4	1.6	-0.4	-1.6	-0.9	-0.9	0.2
Baseline Anxiety	0.6	0.9	3.5	-0.7	0.6	-1.1	-0.9	-0.1	-0.2	-1.9
Tail length	0.5	2.9	6.4	-2.2	2.3	-0.9	-2.5	-1.3	-1.1	-0.3
Length with tail	0.1	0.3	0.7	-0.4	0.5	0.5	-0.9	0.3	0.4	-0.8
Length without tail	1.5	7.7	9.9	3.0	-2.9	3.1	2.8	3.0	2.9	-1.0
Times rat made contact with spout	0.7	0.8	2.3	-0.5	0.6	1.5	-0.7	-0.5	-0.5	1.2
Lifetime Intake	0.2	0.3	1.3	-0.1	0.1	0.4	-0.1	-0.4	-0.4	1.1
Liver weight, left	1.7	2.9	4.6	1.6	-1.6	1.7	1.6	2.1	2.0	-1.3
Liver weight, right	1.3	2.4	3.8	1.3	-1.2	1.6	1.3	2.0	1.6	-1.6
Locomotor activity	2.3	3.5	5.5	2.3	-2.4	1.2	1.8	2.2	2.0	-0.6
Locomotor testing distance	0.6	1.6	2.8	1.7	-1.7	0.7	1.2	1.4	1.2	0.5
Locomotor testing rearing	0.1	0.4	0.8	0.7	-0.7	0.6	0.6	0.9	0.6	-0.2
Locomotion in novel chamber	0.1	0.2	0.4	-0.1	0.2	-0.0	-0.5	-0.2	-0.5	0.6
Locomotion in novel chamber post-restriction	0.1	0.3	0.6	-0.7	0.5	-0.4	-0.7	-0.3	-0.3	-0.8
Fecal boli incidents, locomotor time 1	0.1	0.3	0.8	-0.4	0.3	-0.1	-0.0	-0.8	-0.2	0.9
Change in fecal boli incidents, locomotor task	1.4	1.5	2.4	1.5	-1.5	1.4	1.6	1.0	0.9	-0.4
Time >=10cm from walls, locomotor time 1	0.2	0.3	0.7	0.6	-0.5	0.4	0.3	0.2	0.8	0.8
Bouts of movement, locomotor time 1	0.3	0.4	0.6	0.5	-0.6	-0.0	0.8	0.5	0.6	-0.7
Total resting periods, locomotor time 1	0.2	0.2	0.7	0.4	-0.5	0.1	0.8	0.4	0.4	-0.6
Rest time, locomotor task time 1	0.1	0.2	0.6	-0.2	0.2	0.7	0.4	-0.1	-0.8	0.1
Distance moved, locomotor task time 1	0.3	0.7	1.7	-0.8	0.9	-1.2	-1.3	-0.3	0.2	-0.5
Vertical activity count, locomotor time 1	0.1	0.4	1.2	-0.5	0.6	-1.0	-1.1	-0.3	0.2	-0.3
Time >=10cm from walls, locomotor time 2	0.1	0.2	1.2	-0.0	0.1	-0.1	-0.3	-0.4	-0.2	1.1
Bouts of movement, locomotor time 2	0.2	0.7	3.5	-0.1	0.3	-0.4	-0.5	0.6	0.5	-1.9
Total resting periods, locomotor time 2	0.1	0.5	2.7	-0.0	0.1	-0.3	-0.4	0.6	0.5	-1.6
Rest time, locomotor task time 2	0.5	0.9	2.0	-0.4	0.4	-1.0	-0.1	-1.0	-1.4	1.3
Distance moved, locomotor task time 2	0.3	0.4	1.2	-0.6	0.6	-0.1	-0.8	0.2	0.7	-1.1
Vertical activity count, locomotor time 2	0.3	0.8	1.8	-1.1	1.1	-0.5	-1.3	-1.0	-0.3	0.4
Light reinforcement 1	0.6	2.6	4.9	1.2	-1.2	2.0	1.6	1.9	2.2	-0.3
Light reinforcement 2	0.4	0.9	5.1	0.1	-0.0	0.2	0.1	-0.7	-0.9	2.3
Bone: marrow area	3.1	7.5	11.0	2.9	-2.8	3.3	3.0	2.7	3.0	0.1
Bone: maximum diameter	2.1	4.2	10.6	2.0	-1.9	3.3	1.8	2.1	2.0	-0.3
Bone: maximum force	0.6	1.3	2.7	1.2	-1.1	1.6	0.8	1.3	1.0	-0.5
Bone: maximum moment	0.5	0.9	1.9	1.1	-1.0	1.4	0.7	1.1	0.6	-0.2
Mean time between licks in bursts	0.2	1.3	2.4	-0.7	0.8	-1.4	-0.5	-1.5	-1.0	1.5
Mean num. licks in bursts	0.9	2.4	3.8	1.6	-1.6	1.5	1.2	1.9	0.7	-1.9
Cd content in liver	3.0	3.4	6.2	-2.4	2.4	-1.5	-2.5	-0.9	-0.9	-1.4
Co content in liver	1.2	1.5	2.2	-1.4	1.4	-1.1	-1.5	-1.1	-1.2	0.6
Cu content in liver	0.4	0.5	1.1	0.7	-0.8	1.0	0.7	0.9	0.5	-0.1
Fe content in liver	0.1	0.2	0.8	0.1	-0.1	0.9	-0.0	0.1	0.5	-0.1
K content in liver	0.4	0.4	1.5	0.2	-0.2	0.7	0.2	0.7	0.4	-1.2
Mg content in liver	0.7	0.8	1.2	0.7	-0.7	1.1	0.8	0.9	0.8	-0.9
Mn content in liver	0.7	0.7	2.9	0.5	-0.4	-0.4	0.7	-0.6	-1.0	1.7
Na content in liver	3.0	3.4	5.6	1.6	-1.6	1.8	1.7	2.1	2.4	-1.5
Rb content in liver	1.0	1.2	1.7	1.0	-1.1	1.1	0.7	1.3	1.1	-1.3
Se content in liver	0.2	0.3	0.6	-0.5	0.5	-0.4	-0.5	-0.5	-0.8	0.2
Sr content in liver	2.1	1.8	2.5	-1.4	1.4	-1.6	-1.3	-1.6	-1.0	1.0
Zn content in liver	0.1	0.1	0.2	0.1	-0.1	-0.5	0.0	0.2	-0.2	-0.5
Bone: minimum diameter	0.1	0.2	0.7	0.5	-0.4	0.9	0.4	0.6	-0.1	0.2
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.1	0.0	0.5	0.3	-0.2	0.0	0.5
Time in novel zone, hab. session 1	0.1	0.1	0.3	-0.1	0.1	-0.3	-0.2	-0.2	-0.6	-0.4
Total zone transitions, hab. session 1	2.2	3.1	4.5	-2.1	2.1	-2.1	-2.1	-1.3	-1.1	-1.1
Total locomotion distance, hab. session 1	1.4	2.0	3.8	-1.6	1.5	-2.0	-1.5	-0.8	-0.7	-1.6
Locomotion velocity, hab. session 1	0.7	1.0	2.3	-1.0	1.0	-1.5	-0.9	-0.5	-0.3	-1.1
Time in familiar zone, hab. session 2	0.1	0.2	0.5	-0.4	0.3	0.1	-0.2	-0.7	-0.5	0.2
Time in novel zone, hab. session 2	0.4	0.4	0.8	0.9	-0.8	0.5	0.8	0.8	0.4	0.1
Total zone transitions, hab. session 2	1.6	2.0	3.2	-1.6	1.6	-1.5	-1.8	-0.4	0.2	-1.7
Total locomotion distance, hab. session 2	1.4	1.8	3.1	-1.5	1.5	-1.7	-1.5	-0.6	-0.0	-1.8
Locomotion velocity, hab. session 2	1.2	1.6	3.2	-1.4	1.4	-1.8	-1.3	-0.6	-0.1	-1.4
Novel to familiar place preference ratio	1.3	1.7	2.8	1.4	-1.3	1.3	1.2	1.7	1.4	-0.5
Novelty place preference	1.7	2.2	3.2	1.6	-1.5	1.6	1.5	1.8	1.5	-0.4
Time in novel zone, NPP test	2.4	2.9	4.1	1.8	-1.8	2.0	1.7	2.0	1.6	-0.4
Total zone transitions, NPP test	0.9	1.3	2.3	-1.4	1.4	-1.0	-1.5	-0.4	-0.1	-1.5
Total locomotion distance, NPP test	1.0	1.4	3.4	-1.4	1.4	-1.1	-1.3	-0.4	0.1	-1.8
Locomotion velocity, NPP test	1.6	2.4	3.5	-1.9	1.9	-1.8	-1.8	-0.9	-0.2	-1.6
Intraocular pressure	0.2	0.3	0.5	-0.7	0.6	-0.4	-0.7	-0.4	-0.7	0.1
Delta distance traveled before/after self-admin	2.2	2.4	3.5	1.9	-1.7	1.6	1.8	1.7	1.3	-0.1
Delta ambulatory time before/after self-admin	0.9	1.5	2.4	1.6	-1.4	1.5	1.4	1.1	0.8	0.5
Parametrial fat weight	2.4	5.6	9.6	-2.8	2.7	-1.9	-3.1	-1.8	-2.3	-1.3
Pavlov. Cond. lever latency	0.5	0.6	0.9	0.9	-0.9	0.5	0.7	0.7	-0.5	-1.0
Pavlov. Cond. magazine entry latency	2.6	3.4	5.4	-2.1	2.0	-2.3	-1.6	-2.2	-1.1	1.2
Pavlov. Cond. change in total contacts	0.7	0.7	1.5	-0.8	0.8	-1.1	-0.6	-0.8	-0.0	1.2
Pavlov. Cond. index score	1.9	2.4	3.6	-1.9	1.9	-1.8	-1.5	-1.7	-0.5	1.1
Pavlov. Cond. latency score	1.9	2.4	3.6	-1.9	1.9	-1.7	-1.4	-1.7	-0.4	1.2
Pavlov. Cond. lever contacts	0.6	0.7	1.5	-0.9	0.9	-0.9	-0.6	-0.9	0.3	1.2
Pavlov. Cond. magazine entry number	2.2	2.7	4.2	2.0	-2.0	2.0	1.5	1.8	0.9	-0.8
Pavlov. Cond. intertrial magazine entries	0.6	0.7	2.9	-0.5	0.5	0.6	-0.6	0.6	0.5	-1.7
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.9	-1.7	1.7	-1.6	-1.3	-1.5	-0.2	1.0
Pavlov. Cond. response bias	1.1	1.3	2.2	-1.4	1.4	-1.5	-1.1	-1.3	-0.2	0.6
Pavlov. Cond. lever latency	0.3	0.4	0.6	0.7	-0.5	-0.8	0.7	0.6	0.4	-0.7
Pavlov. Cond. magazine entry latency	3.8	5.3	8.1	-2.3	2.1	-1.8	-2.5	-2.8	-2.9	1.4
Pavlov. Cond. change in total contacts	0.5	1.3	2.6	-1.4	1.2	-0.0	-1.6	-1.2	-1.3	-0.1
Pavlov. Cond. index score	1.3	2.1	3.1	-1.6	1.4	-0.4	-1.7	-1.8	-1.6	1.0
Pavlov. Cond. latency score	0.9	1.5	2.5	-1.3	1.1	-0.1	-1.4	-1.6	-1.4	1.0
Pavlov. Cond. lever contacts	0.3	0.4	1.0	-0.7	0.4	1.0	-0.6	-0.5	-0.4	0.8
Pavlov. Cond. magazine entry number	3.0	3.8	5.5	2.0	-1.9	1.2	2.3	2.3	2.3	-1.1
Pavlov. Cond. intertrial magazine entries	0.5	1.1	2.5	0.9	-0.8	0.7	1.3	1.2	1.6	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.5	3.8	-1.8	1.6	-0.6	-1.8	-2.0	-1.7	1.1
Pavlov. Cond. response bias	1.5	2.1	3.3	-1.8	1.6	-0.5	-1.8	-1.6	-1.5	0.9
Time in closed arm before self-admin	0.1	0.1	0.7	-0.2	0.3	0.1	-0.2	-0.2	0.1	0.9
Time in closed arm after self-admin	0.8	0.9	2.3	-0.7	0.7	-1.1	-0.7	-0.8	-0.8	1.5
Time in open arm before self-admin	1.6	2.0	3.3	1.5	-1.6	1.7	1.8	1.3	1.1	0.4
Time in open arm after self-admin	0.8	0.9	1.8	1.0	-1.0	1.3	1.3	0.7	0.4	-0.6
Bone: periosteal estimation	1.9	4.5	8.5	2.2	-2.1	2.9	2.1	2.3	2.0	0.0
Bone: periosteal perimeter	1.6	3.2	4.6	2.0	-1.9	2.2	1.9	2.0	1.6	-0.7
Bone: post-yield work	0.3	0.5	1.3	0.3	-0.2	1.1	0.6	0.2	0.9	0.9
Progressive ratio test 1 active lever presses	0.1	0.3	1.0	-0.2	0.2	0.6	-0.2	-0.2	-0.5	1.0
Progressive ratio test 1 breakpoint	0.2	0.3	1.1	-0.2	0.2	0.6	-0.1	-0.3	-0.6	1.0
Progressive ratio test 1 inactive lever presses	0.3	0.8	1.8	-0.7	0.7	0.1	-0.4	-0.9	-1.3	1.3
Progressive ratio test 2 active lever presses	0.5	0.8	1.1	0.9	-0.9	1.0	1.0	0.9	0.8	0.3
Progressive ratio test 2 breakpoint	0.4	0.5	0.7	0.8	-0.8	0.9	0.8	0.8	0.7	0.3
Progressive ratio test 2 inactive lever presses	0.0	0.2	0.8	0.2	-0.1	0.1	0.2	-0.1	-0.4	0.9
Incentive Sensitization - Responses	0.6	1.6	2.5	1.4	-1.4	1.0	1.4	1.4	1.6	-0.2
Incentive Sensitization - Breakpoint	0.6	1.3	2.2	1.2	-1.2	0.8	1.2	1.3	1.5	-0.4
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.9	0.7	-0.6	1.0	0.9	0.6	0.6	-0.3
Progressive ratio	0.0	0.0	0.1	-0.1	0.0	-0.2	0.2	-0.3	0.2	0.3
Food seeking constrained by brief footshock	0.6	0.7	3.5	0.1	-0.1	1.9	-0.2	0.5	0.9	-0.6
Seeking ratio, punishment vs. effort	0.8	1.9	3.8	1.1	-1.1	1.9	0.6	1.6	1.4	-1.4
Retroperitoneal fat weight	1.2	5.5	8.0	-2.6	2.6	-2.3	-2.8	-0.9	-1.8	-2.8
Reaction time number correct	0.1	0.2	0.5	0.5	-0.3	0.5	0.3	0.4	0.7	0.1
Reaction time mean minus median	0.1	0.4	0.8	-0.5	0.5	-0.6	-0.9	0.0	-0.6	-0.7
Reaction time mean minus median AUC	0.1	0.7	1.7	-0.8	0.9	-0.6	-1.3	-0.5	-1.0	-0.1
Reaction time num false alarms	0.4	0.6	1.5	-0.7	0.8	-1.0	-1.2	-0.6	-0.7	-0.0
Reaction time num false alarms AUC	0.2	0.4	0.9	-0.5	0.6	-0.9	-0.8	-0.5	-0.4	0.2
Reaction time trials correct on left	0.1	0.2	0.5	0.5	-0.3	0.5	0.3	0.4	0.7	0.1
Reaction time trials on left	0.1	0.2	0.5	0.5	-0.3	0.4	0.2	0.4	0.7	0.1
Reaction time mean	0.5	1.2	2.5	-1.1	1.1	-0.9	-1.4	-0.9	-1.6	0.1
Reaction time mean AUC	0.3	0.7	1.6	-0.9	0.9	-0.4	-1.3	-0.5	-1.2	-0.4
Median of all reaction times	1.1	1.7	3.6	-1.3	1.2	-1.0	-1.5	-1.3	-1.9	0.5
Reaction time omissions	0.4	0.6	2.9	-0.5	0.5	-1.7	-0.6	-0.2	-0.4	-0.5
Reaction time false alarm rate	0.5	0.7	1.3	-0.8	0.8	-1.1	-1.1	-0.7	-0.9	0.2
Reaction time premature initiation rate	0.1	0.1	0.4	0.3	-0.1	0.1	-0.3	0.6	0.4	-0.4
Reaction time premature initiations	0.1	0.2	0.6	0.5	-0.3	0.3	-0.1	0.8	0.8	-0.3
Std. dev. reaction times	0.4	1.2	2.1	-1.1	1.0	-1.2	-1.5	-0.7	-1.3	-0.5
Reaction time trials completed	0.1	0.2	0.5	0.5	-0.3	0.4	0.2	0.4	0.7	0.1
Reaction time trials AUC	0.0	0.2	0.5	0.4	-0.3	0.5	0.2	0.4	0.7	0.1
Run reversals in cocaine runway, females	0.1	0.1	0.5	-0.1	0.1	-0.5	-0.1	-0.5	-0.7	0.0
Run reversals in cocaine runway, males	0.6	0.7	1.9	-0.2	0.0	1.2	0.0	0.8	0.8	-1.4
Latency to leave start box in cocaine runway	1.1	1.5	2.6	1.6	-1.6	0.5	1.5	1.1	1.4	-0.4
Latency to leave start box in cocaine runway, F	0.3	0.4	0.6	0.7	-0.8	0.2	0.8	0.7	0.8	-0.6
Latency to leave start box in cocaine runway, M	2.9	2.7	4.9	2.2	-2.2	0.7	1.8	1.5	1.8	-0.5
Std. dev. time between licks in bursts	0.2	0.3	0.6	-0.4	0.6	-0.8	-0.1	-0.7	0.3	0.8
Total sessions with >9 infusions	0.1	0.1	0.6	0.1	-0.2	0.3	0.2	-0.2	-0.2	0.8
Short access day 1 total inactive lever presses	0.1	0.2	0.5	0.5	-0.6	-0.1	0.5	-0.2	-0.5	0.7
Short access day 10 total inactive lever presses	0.0	0.3	0.8	-0.2	0.1	-0.9	0.5	-0.7	-0.4	0.6
Short access day 1 total infusions	0.2	0.3	1.1	0.6	-0.5	0.2	0.6	0.1	0.2	1.1
Short access day 10 total infusions	0.5	0.8	1.8	-0.7	0.7	0.2	-0.9	-1.0	-1.3	1.0
Short access total infusions	0.3	0.5	1.2	-0.5	0.5	-0.1	-0.5	-0.8	-0.8	1.1
Short access day 1 locomotion	0.1	0.1	0.3	0.4	-0.4	0.3	0.5	0.3	0.3	0.1
Short access day 10 total locomotion	0.1	0.4	1.2	0.6	-0.8	0.3	1.1	0.1	-0.1	0.8
Short access total locomotion	0.2	0.4	1.5	0.2	-0.3	-0.2	0.6	-0.4	-0.5	1.2
One hour access (0.3 mA shock)	0.6	0.7	1.3	0.8	-0.8	1.1	1.0	0.8	0.6	-0.2
Compulsive drug intake	0.5	0.7	1.3	0.9	-1.0	0.9	1.1	-0.0	-0.1	1.1
One hour access (shock baseline)	0.0	0.0	0.1	-0.3	0.4	0.1	-0.3	0.0	-0.0	0.0
Social response proportion	0.8	1.0	1.8	1.4	-1.4	0.7	1.0	0.9	0.2	0.9
Social responses	0.6	0.7	4.5	-0.2	0.3	0.0	-0.2	-0.6	-0.4	2.1
Social time	0.3	0.5	0.8	0.9	-0.9	0.4	0.9	0.6	0.5	0.1
Soleus weight	12.8	37.7	54.9	6.5	-6.4	5.8	6.4	6.7	7.4	-2.7
Bone: stiffness	0.7	1.3	2.3	1.1	-1.0	1.2	0.8	1.5	1.3	-1.2
Tibialis anterior weight	11.8	40.6	52.7	7.3	-7.2	5.7	6.7	6.6	7.1	-2.8
Time to tail flick, vehicle, before self-admin	1.1	1.3	3.1	-1.5	1.4	-0.1	-1.7	-0.6	-0.9	-0.8
Time to tail flick, vehicle, after self-admin	0.4	0.7	1.6	0.9	-0.8	1.3	0.6	0.4	0.5	1.2
Time to tail flick, test, before self-admin	1.5	1.7	3.5	-1.6	1.6	-1.2	-1.9	-0.9	-1.1	-0.1
Time to tail flick, test, after self-admin	3.0	3.1	4.8	-1.9	1.8	-1.1	-1.7	-2.2	-1.4	2.1
Delta time to tail flick, vehicle, before/after SA	1.0	1.1	1.6	1.3	-1.2	0.7	1.2	0.5	1.1	1.1
Delta time to tail flick, test, before/after SA	0.7	0.8	3.7	0.6	-0.7	0.7	0.9	-0.3	0.2	1.9
Tibia length	0.6	1.7	5.1	1.3	-1.3	2.3	1.2	1.0	0.5	1.0
Ambulatory time before self-admin	0.1	0.2	0.4	0.3	-0.4	0.2	0.6	0.1	0.6	-0.4
Ambulatory time after self-admin	1.9	3.1	4.4	2.1	-2.0	2.1	2.1	1.5	1.5	-0.1
Bone: tissue strength	0.2	0.2	0.5	-0.2	0.3	0.2	-0.5	-0.2	-0.7	-0.4
Total heroin consumption	0.7	0.8	1.6	0.5	-0.4	1.3	0.8	0.9	1.2	-0.7
Bone: trabecular number	1.2	2.4	3.8	-1.9	1.9	-1.6	-1.7	-1.5	-1.1	0.5
Bone: trabecular spacing	0.2	0.2	0.9	-0.0	-0.0	-0.6	-0.7	0.0	-0.2	-0.9
Bone: trabecular thickness	0.1	0.2	0.4	-0.2	0.2	-0.2	-0.2	-0.3	-0.7	0.6
Bone: trabecular tissue density	4.2	7.3	11.6	3.4	-3.3	1.9	2.8	3.1	2.3	-1.4
Water consumed over 24 hours	0.3	0.7	2.4	-0.2	0.2	1.5	-0.1	-0.4	-0.2	1.4
Number of responses in last shaping day	0.3	0.4	2.4	0.0	-0.1	0.6	0.4	-0.3	0.2	1.6