Hub : Genes

Knop1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Knop1 0.07 0.05 9.2e-03 0.01 0.03 0.02 0.02 8.7e-02 2.6e-02 3.7e-02 5.0e-02
2 PL gene expression Knop1 0.13 0.07 6.3e-10 0.07 0.08 0.08 0.07 2.0e-08 4.4e-09 1.5e-09 1.3e-08
3 Brain gene expression Knop1 0.05 0.04 1.2e-03 0.02 0.01 0.02 0.01 3.9e-03 6.0e-02 6.1e-03 1.7e-02
4 NAcc gene expression Knop1 0.07 0.03 1.3e-09 0.05 0.08 0.07 0.07 1.5e-06 3.0e-09 1.1e-08 3.8e-08
5 BLA mRNA stability Knop1 0.09 0.06 6.2e-03 0 -0 0 0 2.5e-01 3.8e-01 3.1e-01 2.7e-01
6 NAcc mRNA stability Knop1 0.05 0.03 3.2e-04 0.01 0.03 0.02 0.03 8.4e-03 2.1e-04 3.2e-03 3.9e-04
7 Adipose mRNA stability Knop1 0.1 0.05 2.0e-10 0.09 0.07 0.07 0.08 1.9e-10 5.7e-08 1.1e-08 1.4e-09
8 Liver gene expression Knop1 0.05 0.03 9.1e-04 -0 0 -0 -0 4.3e-01 1.5e-01 4.2e-01 4.8e-01
9 Brain mRNA stability Knop1 0.07 0.04 1.0e-04 0.01 0.04 0.03 0.03 5.6e-02 3.4e-04 4.9e-04 1.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.81.42.51.5-1.5-1.61.3-1.21.20.10.90.5
Area under the delay curve0.10.10.4-0.4-0.00.6-0.20.10.3-0.3-0.10.2
BMI with tail1.54.910.03.2-2.6-3.02.5-2.41.11.81.2-0.2
BMI without tail4.89.920.34.5-4.0-4.33.5-3.41.82.01.7-0.2
Body weight1.66.813.23.6-3.6-3.33.0-2.71.91.51.40.0
Weight adjusted by age0.30.31.00.30.5-0.5-0.3-0.1-1.00.8-0.0-0.6
Bone surface0.71.22.31.4-1.5-1.51.5-0.60.61.0-0.0-0.6
Bone volume1.32.24.01.9-2.0-2.01.9-1.31.30.80.6-0.0
Breakpoint value in progressive ratio session1.21.33.3-1.11.21.2-1.80.2-0.6-1.70.71.0
Number of licking bursts4.65.410.4-3.23.02.7-2.13.0-1.8-0.2-2.2-0.9
Context. condit. distance diff. score0.30.40.8-0.60.70.8-0.90.4-0.7-0.7-0.00.0
Locomotion velocity, session 10.10.10.30.2-0.4-0.50.50.10.5-0.1-0.10.0
Locomotion distance, session 10.81.11.91.4-1.2-1.40.9-1.30.8-0.11.00.5
Locomotion velocity, session 20.00.00.2-0.2-0.1-0.30.10.10.4-0.0-0.10.2
Locomotion distance, session 21.52.14.61.9-1.9-2.11.8-1.41.30.50.70.1
Locomotion velocity, session 30.40.41.10.9-1.0-0.80.7-0.60.50.20.3-0.0
Locomotion distance, session 30.60.72.00.3-0.6-0.10.70.7-0.51.1-1.2-1.4
Stereotopy head waving bouts, day 30.40.40.9-0.60.60.7-0.90.0-0.2-0.90.40.7
Stereotopy head waving duration, day 30.30.41.0-0.40.40.5-0.8-0.30.0-1.00.70.9
Locomotion velocity, session 71.61.73.81.3-1.7-1.21.4-0.0-0.22.0-0.9-1.7
Locomotion distance, session 70.81.02.6-0.2-0.10.30.40.9-0.71.6-1.5-1.6
Stereotopy head waving bouts, day 70.50.60.90.8-0.9-0.70.4-0.90.7-0.70.90.6
Stereotopy head waving duration, day 71.21.53.01.7-1.6-1.61.2-1.30.80.11.00.3
Locomotion velocity, session 80.10.20.50.3-0.5-0.40.3-0.20.4-0.70.30.2
Locomotion distance, session 80.10.20.50.6-0.6-0.70.5-0.40.20.00.2-0.1
Degree of sensitization distance0.60.61.8-0.20.40.4-0.5-0.70.6-0.81.01.3
Degree of sensitization stereotypy1.31.43.01.6-1.7-1.61.3-1.10.90.10.60.0
Conditioned locomotion1.21.42.5-0.80.70.7-0.61.6-1.51.2-1.5-1.6
Cocaine response after cond. corrected0.10.20.4-0.60.60.3-0.40.5-0.3-0.2-0.3-0.1
Cocaine response after cond. not corrected0.10.10.20.2-0.3-0.50.40.1-0.00.2-0.3-0.4
Cocaine response before conditioning1.61.94.21.8-2.0-1.61.8-0.80.71.4-0.2-0.9
Saline control response0.20.20.4-0.30.50.6-0.6-0.2-0.1-0.50.40.6
Bone: connectivity density0.30.41.01.0-0.9-1.00.8-0.50.30.40.2-0.2
Bone: cortical apparent density0.50.61.4-1.11.01.2-0.70.7-0.3-0.7-0.50.1
Bone: cortical area2.74.17.12.5-2.7-2.72.6-2.01.81.40.80.1
Bone: cortical porosity0.60.61.51.2-1.1-1.00.6-0.90.20.50.6-0.0
Bone: cortical porosity0.20.20.60.8-0.7-0.5-0.0-0.6-0.20.10.6-0.0
Bone: cortical thickness1.72.84.41.8-2.1-1.92.1-1.82.10.61.00.7
Bone: cortical thickness1.01.23.70.7-1.1-0.51.1-1.11.9-0.40.91.2
Bone: cortical tissue density0.50.61.5-1.11.01.2-0.80.7-0.3-0.7-0.50.1
Condit. Reinf. active minus inactive responses0.10.10.4-0.20.40.3-0.6-0.0-0.3-0.50.30.3
Condit. Reinf. active-inactive response ratio0.10.10.4-0.00.30.0-0.50.1-0.6-0.20.1-0.2
Condit. Reinf. active responses0.10.10.3-0.30.50.3-0.5-0.1-0.1-0.40.40.5
Condit. Reinf. inactive responses0.10.10.3-0.10.20.1-0.0-0.30.4-0.10.40.6
Incentive salience index mean0.10.20.50.00.1-0.3-0.10.3-0.60.7-0.4-0.6
Condit. Reinf. lever presses0.71.02.1-0.40.60.0-0.31.0-1.31.4-1.2-1.4
Condit. Reinf. active minus inactive responses0.80.92.90.8-0.1-0.3-0.1-1.40.6-0.81.71.3
Condit. Reinf. active-inactive response ratio0.80.92.30.10.60.3-0.7-1.00.3-1.21.51.4
Condit. Reinf. active responses0.30.51.40.8-0.3-0.20.1-1.00.4-0.31.20.8
Condit. Reinf. inactive responses0.70.91.71.1-1.3-0.91.2-0.20.11.3-0.4-1.0
Condit. Reinf. lever presses0.71.02.21.5-1.0-1.20.8-1.30.60.11.10.4
Condit. Reinf. lever reinforcers received0.20.31.10.50.00.1-0.3-0.80.0-0.51.00.7
Conditioned reinforcement - actives1.31.33.30.9-1.0-0.50.8-1.01.8-0.11.51.6
Conditioned reinforcement - inactives0.40.51.1-0.50.60.7-0.20.40.8-1.10.51.1
Conditioned locomotion0.00.00.2-0.1-0.10.4-0.10.20.20.20.10.2
Patch foraging indifference point 0 sec1.32.14.51.2-1.1-0.80.3-2.01.4-1.52.11.8
Patch foraging indifference point AUC0.70.81.70.9-0.6-0.71.0-1.11.3-0.20.90.9
Delay disc. indifference point, 0s delay0.50.51.80.5-0.9-0.31.30.00.80.8-0.6-0.5
Delay disc. indifference point, 16s delay2.82.85.4-2.21.92.3-2.31.0-0.7-1.9-0.00.9
Delay disc. indifference point, 2s delay2.83.16.32.2-2.4-1.92.5-1.51.51.50.3-0.3
Delay disc. indifference point, 24s delay2.52.44.6-2.11.82.0-1.91.7-1.2-1.1-0.9-0.2
Delay disc. indifference point, 4s delay0.40.41.60.2-0.60.00.6-0.61.3-0.20.50.8
Delay disc. indifference point, 8s delay0.10.10.4-0.0-0.50.00.40.20.40.6-0.4-0.2
Indifference point function ln k0.30.41.10.8-0.9-1.10.6-0.60.50.70.40.1
Indifference point function log k0.30.41.10.8-0.9-1.10.6-0.60.50.70.40.1
Patch foraging total patch changes 0 sec1.52.45.21.3-1.1-0.90.3-2.11.4-1.52.31.9
Patch foraging total patch changes 12 sec0.10.20.40.5-0.1-0.30.2-0.70.2-0.40.50.3
Patch foraging total patch changes 18 sec0.30.41.4-0.00.10.4-0.1-0.50.7-1.20.70.9
Patch foraging total patch changes 24 sec1.21.42.81.1-1.0-0.80.6-1.71.3-1.01.51.3
Patch foraging total patch changes 6 sec2.53.710.00.10.20.3-0.6-1.81.8-3.22.63.1
Patch foraging time to switch 0 sec3.04.78.3-2.12.01.6-1.82.8-2.90.6-2.5-2.3
Patch foraging water rate 0 sec0.20.30.50.7-0.7-0.50.6-0.70.60.20.50.4
Patch foraging water rate 12 sec2.03.15.71.8-1.9-1.31.1-2.42.0-0.72.21.8
Patch foraging water rate 18 sec0.60.91.81.0-1.1-0.60.3-1.20.8-0.41.41.0
Patch foraging water rate 24 sec0.71.01.91.0-1.4-0.51.1-1.11.40.50.80.7
Patch foraging water rate 6 sec0.60.92.50.2-0.2-0.40.4-0.91.5-0.81.21.6
Seeking ratio, delayed vs. immediate footshock0.10.10.20.2-0.1-0.40.1-0.10.30.20.40.3
Distance traveled before self-admin0.20.20.90.2-0.3-0.40.6-0.10.90.50.30.5
Distance traveled after self-admin1.71.93.81.4-1.7-1.81.9-0.71.21.7-0.1-0.3
Extensor digitorum longus weight2.911.422.64.1-4.3-4.54.8-1.71.93.8-0.5-1.9
Bone: elastic displacement0.50.62.1-0.50.40.4-0.6-0.30.5-1.40.81.2
Bone: elastic work0.40.50.80.7-0.8-0.80.7-0.80.90.00.60.5
Bone: endosteal estimation0.91.93.41.8-1.6-1.81.7-0.60.21.8-0.2-1.1
Bone: endosteal perimeter0.81.63.91.0-1.0-1.61.40.2-0.32.0-1.1-1.6
Epididymis fat weight0.61.42.91.6-1.1-1.40.9-1.70.90.11.50.9
Delta time in closed arm before/after self-admin1.31.33.0-0.70.50.7-0.51.2-1.60.7-1.7-1.7
Delta time in open arm before/after self-admin2.32.24.01.7-1.5-1.61.5-2.01.7-0.11.51.1
Diff in mean of infusions in LGA sessions1.01.13.1-0.51.00.4-1.1-0.50.4-1.41.51.8
Delay discount exponential model param0.10.10.40.4-0.0-0.60.3-0.2-0.10.20.2-0.1
Extinction: sum of active levers before priming0.40.40.7-0.80.80.8-0.60.7-0.5-0.6-0.5-0.2
Active lever presses in extinction session 60.40.41.1-0.10.30.6-0.6-0.40.1-1.10.90.9
Bone: final force4.16.611.33.3-3.2-3.33.4-2.52.21.71.20.1
Bone: final moment3.55.79.83.1-3.0-3.03.0-2.52.21.41.40.4
Food consumed during 24 hour testing period1.21.53.11.4-1.4-1.71.7-1.01.21.00.40.0
Glucose0.50.72.10.3-0.3-0.10.1-0.81.2-0.91.31.4
Heart weight0.50.72.2-0.10.30.2-0.1-0.91.0-1.11.11.5
Delay discount hyperbolic model param0.00.00.10.10.3-0.4-0.10.0-0.40.10.1-0.2
Intermittent access intake day 1-15 change1.21.22.9-1.31.41.2-0.31.7-0.40.4-1.3-0.6
Intermittent access intake escalation0.80.82.1-1.11.21.1-0.21.5-0.20.2-1.0-0.4
Intermittent access intake escalation 21.21.22.7-1.31.41.4-0.31.6-0.50.4-1.2-0.6
Intermitt. access day 1 inactive lever presses0.20.21.2-0.40.21.10.10.20.50.1-0.00.4
Intermitt. access day 15 inactive lever presses0.40.41.10.7-0.8-0.51.0-0.00.41.0-0.3-0.5
Intermitt. access escalation Index0.30.30.60.7-0.4-0.80.7-0.50.40.50.40.1
Intermittent access day 1 total infusions1.51.73.31.6-1.6-0.90.7-1.81.1-0.61.71.1
Intermittent access day 15 total infusions0.30.30.70.4-0.20.10.3-0.40.7-0.60.80.8
Intermittent access terminal intake (last 3 days)0.30.30.90.4-0.20.20.3-0.60.7-0.50.90.9
Intermittent access total infusions1.21.32.61.4-1.2-0.50.7-1.51.2-0.31.61.2
Intermittent access day 1 locomotion1.61.73.51.4-1.2-0.90.5-1.91.1-0.91.91.4
Intermittent access day 15 total locomotion2.12.35.9-0.71.21.3-1.1-0.50.8-2.41.82.3
Intermittent access total locomotion1.61.85.30.9-0.2-0.1-0.0-1.81.1-1.42.32.0
Intermittent access standard deviation0.10.10.50.2-0.20.20.70.10.70.0-0.10.1
Left kidney weight2.67.212.23.5-3.4-3.43.3-2.72.51.71.60.5
Right kidney weight3.08.414.33.8-3.8-3.73.6-2.92.61.81.60.4
Cocaine induced anxiety0.20.31.1-0.61.10.4-0.50.4-0.5-0.3-0.10.0
Post-drug Anxiety0.40.51.5-0.30.50.5-0.4-0.30.6-0.80.91.2
Baseline Anxiety1.31.33.01.1-1.5-0.91.1-1.11.70.21.11.1
Tail length2.16.312.93.3-3.6-2.92.8-2.82.20.91.60.5
Length with tail0.51.74.21.6-2.0-1.41.6-1.31.40.10.70.3
Length without tail0.30.71.6-1.30.71.0-0.71.1-0.3-0.6-0.9-0.2
Times rat made contact with spout1.41.64.31.0-1.3-1.31.80.00.52.1-1.0-1.2
Lifetime Intake1.82.13.51.8-1.7-0.81.1-1.91.5-0.11.81.2
Liver weight, left0.10.10.40.7-0.4-0.50.2-0.5-0.00.20.50.1
Liver weight, right0.30.51.60.5-0.1-0.20.10.3-1.11.1-0.6-1.3
Locomotor activity0.10.10.40.10.10.5-0.3-0.2-0.4-0.60.1-0.1
Locomotor testing distance0.20.30.90.6-0.4-0.10.2-1.00.4-0.70.80.5
Locomotor testing rearing0.10.20.60.10.20.6-0.6-0.4-0.4-0.70.50.3
Locomotion in novel chamber0.70.92.31.1-0.5-0.90.3-1.40.6-0.41.51.0
Locomotion in novel chamber post-restriction1.11.33.1-0.30.90.8-0.9-1.00.4-1.81.61.7
Fecal boli incidents, locomotor time 10.91.03.1-0.71.00.3-1.11.1-1.80.3-0.8-1.1
Change in fecal boli incidents, locomotor task3.23.15.91.1-1.5-0.50.6-2.42.2-1.32.32.4
Time >=10cm from walls, locomotor time 10.60.61.40.9-0.9-1.01.2-0.50.80.60.2-0.0
Bouts of movement, locomotor time 12.72.97.0-2.22.61.7-2.21.7-1.6-1.1-0.6-0.0
Total resting periods, locomotor time 13.13.47.0-2.32.72.0-2.31.8-1.9-1.1-0.9-0.3
Rest time, locomotor task time 11.21.33.0-1.20.81.2-0.71.7-1.00.1-1.6-1.2
Distance moved, locomotor task time 12.02.24.41.6-1.3-1.41.1-2.11.5-0.41.81.4
Vertical activity count, locomotor time 13.13.25.71.9-1.7-1.92.1-2.12.40.21.71.5
Time >=10cm from walls, locomotor time 21.92.04.11.7-2.0-1.62.0-0.81.21.40.1-0.4
Bouts of movement, locomotor time 21.11.23.4-0.00.70.0-0.31.1-1.80.7-1.3-1.8
Total resting periods, locomotor time 20.80.93.00.30.4-0.3-0.00.8-1.60.8-1.1-1.7
Rest time, locomotor task time 20.10.10.30.3-0.5-0.20.1-0.50.4-0.30.40.4
Distance moved, locomotor task time 20.40.41.40.4-0.6-0.61.20.10.70.9-0.4-0.3
Vertical activity count, locomotor time 20.80.92.80.7-0.9-0.81.4-0.61.7-0.10.50.8
Light reinforcement 10.30.51.3-0.20.40.7-0.9-0.4-0.3-1.10.80.7
Light reinforcement 20.30.41.10.20.00.2-0.5-0.70.1-0.81.00.8
Bone: marrow area0.81.73.01.7-1.5-1.71.6-0.50.11.7-0.3-1.1
Bone: maximum diameter1.42.65.72.1-1.9-2.42.0-1.51.01.30.4-0.3
Bone: maximum force3.35.710.13.1-3.0-3.13.2-2.22.11.61.00.1
Bone: maximum moment2.84.98.12.8-2.8-2.82.8-2.22.01.21.20.3
Mean time between licks in bursts0.40.61.2-0.71.00.1-0.50.9-1.10.6-0.8-0.8
Mean num. licks in bursts5.66.712.33.5-3.5-3.23.0-2.82.11.21.50.3
Cd content in liver3.23.57.2-2.01.92.5-2.70.5-0.8-2.70.71.4
Co content in liver1.01.23.5-0.40.30.8-0.6-0.91.0-1.51.31.9
Cu content in liver1.01.22.40.7-0.6-0.40.4-1.51.3-1.01.61.6
Fe content in liver0.40.51.0-0.90.81.0-0.50.30.5-0.80.20.9
K content in liver0.00.00.10.10.3-0.1-0.1-0.2-0.10.00.30.2
Mg content in liver0.50.51.6-0.41.00.6-1.00.4-1.3-0.0-0.2-0.4
Mn content in liver0.40.41.50.2-0.2-0.50.40.4-0.41.2-0.8-1.0
Na content in liver3.13.38.81.9-1.6-2.22.3-0.10.13.0-1.0-1.9
Rb content in liver1.92.35.9-0.40.60.8-1.2-1.40.8-2.32.12.4
Se content in liver0.20.20.80.00.2-0.30.50.40.00.9-0.4-0.4
Sr content in liver0.30.20.60.7-0.6-0.70.7-0.40.20.40.0-0.3
Zn content in liver1.21.33.11.8-1.3-1.71.4-1.10.40.80.3-0.5
Bone: minimum diameter1.22.34.51.9-2.0-2.12.0-1.00.61.6-0.1-0.9
Time in familiar zone, hab. session 10.90.82.2-0.60.70.4-0.4-0.30.9-1.50.91.5
Time in novel zone, hab. session 11.01.02.70.9-1.4-0.50.50.1-0.91.2-0.8-1.6
Total zone transitions, hab. session 13.04.26.12.4-2.4-2.52.2-2.22.4-0.01.81.2
Total locomotion distance, hab. session 15.88.212.23.5-3.4-3.32.9-3.53.0-0.22.61.7
Locomotion velocity, hab. session 14.66.510.33.1-2.8-2.92.4-3.22.6-0.32.61.7
Time in familiar zone, hab. session 20.30.30.60.6-0.5-0.50.7-0.70.70.10.50.4
Time in novel zone, hab. session 20.10.10.2-0.10.10.0-0.40.1-0.3-0.40.10.0
Total zone transitions, hab. session 22.63.35.02.2-2.2-2.21.8-2.11.9-0.31.71.1
Total locomotion distance, hab. session 23.64.76.92.6-2.6-2.62.3-2.52.4-0.21.91.3
Locomotion velocity, hab. session 23.75.07.82.7-2.7-2.82.5-2.52.40.11.81.1
Novel to familiar place preference ratio0.50.61.6-1.11.30.9-0.70.6-0.1-0.4-0.20.5
Novelty place preference0.50.51.4-1.21.20.8-0.60.7-0.0-0.3-0.30.4
Time in novel zone, NPP test0.50.51.3-1.01.10.8-0.70.40.1-0.70.00.6
Total zone transitions, NPP test1.72.43.81.9-1.9-2.01.7-1.71.60.11.20.7
Total locomotion distance, NPP test1.92.63.81.8-1.8-1.91.9-1.91.9-0.11.31.0
Locomotion velocity, NPP test1.62.33.31.7-1.7-1.81.7-1.71.80.31.10.8
Intraocular pressure0.10.20.50.6-0.7-0.30.3-0.4-0.20.6-0.1-0.5
Delta distance traveled before/after self-admin0.91.02.31.3-1.5-1.31.1-0.70.20.9-0.2-0.8
Delta ambulatory time before/after self-admin0.90.92.01.2-1.4-1.41.2-0.70.40.8-0.1-0.6
Parametrial fat weight2.75.28.92.8-2.4-3.02.2-2.62.30.32.31.5
Pavlov. Cond. lever latency1.62.05.6-0.40.00.7-0.2-0.81.9-2.41.52.3
Pavlov. Cond. magazine entry latency1.82.38.41.4-0.8-1.50.9-0.1-1.32.9-0.9-2.1
Pavlov. Cond. change in total contacts3.43.710.40.1-0.0-0.20.41.4-2.13.2-2.5-3.1
Pavlov. Cond. index score2.12.68.10.6-0.1-0.80.30.7-2.12.8-1.6-2.6
Pavlov. Cond. latency score1.62.16.70.7-0.1-0.90.30.5-1.82.6-1.3-2.3
Pavlov. Cond. lever contacts2.42.88.70.6-0.3-0.90.50.9-2.02.9-1.8-2.7
Pavlov. Cond. magazine entry number2.32.99.2-0.60.20.7-0.5-0.82.0-3.01.92.8
Pavlov. Cond. intertrial magazine entries1.61.96.0-0.70.71.1-1.0-0.60.9-2.51.52.1
Pavlov. Cond. lever-magazine prob. diff.2.22.78.70.8-0.2-1.00.50.6-2.02.9-1.5-2.6
Pavlov. Cond. response bias3.13.711.10.5-0.2-0.70.51.2-2.33.3-2.2-3.2
Pavlov. Cond. lever latency0.60.81.7-1.31.01.0-0.91.1-0.7-0.2-0.9-0.4
Pavlov. Cond. magazine entry latency2.02.43.9-1.61.51.3-1.22.0-1.90.6-1.8-1.5
Pavlov. Cond. change in total contacts0.81.02.60.20.20.2-0.5-1.10.6-1.51.61.6
Pavlov. Cond. index score0.10.10.2-0.20.50.2-0.40.3-0.50.0-0.1-0.1
Pavlov. Cond. latency score0.10.10.2-0.10.30.1-0.20.3-0.50.2-0.2-0.3
Pavlov. Cond. lever contacts0.60.81.81.4-1.0-1.10.8-1.10.50.40.80.2
Pavlov. Cond. magazine entry number1.61.93.51.8-1.9-1.71.7-1.51.40.50.80.3
Pavlov. Cond. intertrial magazine entries1.62.14.32.1-1.8-1.91.6-1.60.90.71.00.1
Pavlov. Cond. lever-magazine prob. diff.0.20.30.6-0.50.70.4-0.60.5-0.80.1-0.3-0.3
Pavlov. Cond. response bias0.00.00.10.20.1-0.1-0.2-0.2-0.20.20.30.1
Time in closed arm before self-admin1.11.22.21.2-1.0-1.51.0-1.21.3-0.21.20.9
Time in closed arm after self-admin0.70.72.0-0.60.60.6-0.9-0.20.3-1.40.81.2
Time in open arm before self-admin2.42.66.0-1.91.92.5-1.71.7-1.6-0.0-1.2-0.7
Time in open arm after self-admin0.60.72.10.9-0.8-0.51.4-0.30.41.2-0.5-0.7
Bone: periosteal estimation2.04.27.92.7-2.6-2.82.7-1.61.22.00.3-0.7
Bone: periosteal perimeter1.01.63.91.7-1.5-2.01.5-1.00.41.30.1-0.7
Bone: post-yield work1.52.14.42.1-1.7-1.81.2-1.80.80.21.50.5
Progressive ratio test 1 active lever presses0.50.51.20.8-0.6-0.20.2-1.00.5-0.61.10.7
Progressive ratio test 1 breakpoint0.40.51.10.8-0.6-0.10.2-1.00.4-0.61.10.7
Progressive ratio test 1 inactive lever presses0.20.30.50.7-0.5-0.30.5-0.70.5-0.10.70.4
Progressive ratio test 2 active lever presses0.50.61.40.8-0.8-0.00.1-1.10.6-0.31.20.8
Progressive ratio test 2 breakpoint0.50.51.40.8-0.70.20.0-1.10.5-0.21.20.8
Progressive ratio test 2 inactive lever presses0.40.41.20.4-0.20.5-0.2-0.80.4-0.71.11.0
Incentive Sensitization - Responses0.10.10.20.2-0.30.2-0.3-0.3-0.40.50.2-0.2
Incentive Sensitization - Breakpoint0.10.10.20.3-0.40.2-0.3-0.4-0.30.40.3-0.0
Sum of active levers in priming session hrs 5-60.20.20.5-0.10.40.4-0.7-0.1-0.6-0.40.30.1
Progressive ratio0.80.92.50.1-0.10.0-0.4-1.00.8-1.21.41.6
Food seeking constrained by brief footshock0.70.82.0-1.41.21.1-1.10.7-0.3-0.7-0.30.4
Seeking ratio, punishment vs. effort0.50.61.7-0.10.1-0.10.20.8-0.81.2-1.1-1.3
Retroperitoneal fat weight0.72.26.11.1-0.8-0.7-0.2-2.21.0-1.22.52.0
Reaction time number correct0.60.91.7-1.00.91.1-1.30.8-1.1-1.0-0.4-0.2
Reaction time mean minus median0.10.20.60.20.0-0.80.4-0.30.5-0.30.40.4
Reaction time mean minus median AUC0.40.51.9-0.10.5-0.3-0.4-0.40.3-1.41.01.1
Reaction time num false alarms0.70.92.1-1.51.31.1-0.51.2-0.4-0.0-1.2-0.4
Reaction time num false alarms AUC0.70.91.7-1.31.21.0-0.61.2-0.70.1-1.2-0.7
Reaction time trials correct on left0.60.91.7-1.00.91.1-1.30.8-1.1-1.0-0.4-0.2
Reaction time trials on left0.60.91.8-1.00.91.0-1.30.8-1.1-1.0-0.3-0.2
Reaction time mean0.30.41.00.7-0.4-1.00.4-0.80.5-0.00.70.5
Reaction time mean AUC0.10.10.50.4-0.1-0.70.1-0.50.00.10.40.2
Median of all reaction times0.20.30.90.7-0.4-0.90.4-0.70.30.20.60.3
Reaction time omissions0.50.72.2-0.60.80.1-1.00.9-1.5-0.0-0.7-0.9
Reaction time false alarm rate0.30.41.2-0.70.50.40.30.8-0.10.8-1.1-0.7
Reaction time premature initiation rate1.21.73.01.3-1.7-1.61.7-0.50.61.7-0.6-1.0
Reaction time premature initiations0.50.71.50.5-1.0-0.90.80.2-0.21.1-1.0-1.2
Std. dev. reaction times0.30.51.00.7-0.4-1.00.4-0.80.7-0.40.90.7
Reaction time trials completed0.60.91.8-1.00.91.0-1.30.8-1.1-1.0-0.3-0.2
Reaction time trials AUC0.40.61.3-0.80.70.8-1.10.6-0.9-0.9-0.2-0.2
Run reversals in cocaine runway, females5.25.19.62.6-3.1-3.13.0-1.71.91.90.3-0.3
Run reversals in cocaine runway, males0.20.20.5-0.70.50.2-0.40.6-0.2-0.4-0.4-0.1
Latency to leave start box in cocaine runway0.91.03.20.0-0.00.1-0.5-0.90.6-1.81.41.5
Latency to leave start box in cocaine runway, F0.20.20.6-0.40.40.3-0.80.2-0.7-0.80.1-0.0
Latency to leave start box in cocaine runway, M1.71.74.40.2-0.30.1-0.1-1.31.6-1.71.82.1
Std. dev. time between licks in bursts0.20.20.6-0.10.80.2-0.20.3-0.80.6-0.2-0.4
Total sessions with >9 infusions4.34.89.72.9-3.1-2.42.5-2.12.01.51.30.4
Short access day 1 total inactive lever presses0.30.40.70.4-0.50.40.1-0.60.7-0.60.80.8
Short access day 10 total inactive lever presses0.50.61.8-1.00.91.3-0.50.80.1-0.4-0.30.4
Short access day 1 total infusions2.02.13.81.8-1.9-0.51.2-1.91.70.41.71.2
Short access day 10 total infusions1.51.73.21.8-1.8-1.71.4-1.31.10.51.00.3
Short access total infusions3.03.45.72.4-2.4-1.31.5-2.41.90.32.11.3
Short access day 1 locomotion0.60.71.30.8-1.0-0.40.6-0.91.10.20.90.8
Short access day 10 total locomotion1.01.12.91.5-1.0-1.00.9-1.70.60.21.10.4
Short access total locomotion3.53.67.52.0-1.7-1.10.9-2.71.9-0.82.72.1
One hour access (0.3 mA shock)1.41.73.61.7-1.2-1.01.0-1.91.00.21.70.9
Compulsive drug intake0.20.20.80.3-0.10.1-0.4-0.9-0.50.20.40.0
One hour access (shock baseline)0.30.41.0-0.10.30.5-0.1-0.10.7-1.00.81.0
Social response proportion0.60.62.3-0.30.70.4-0.9-0.3-0.2-1.50.90.9
Social responses0.81.12.3-1.11.51.0-1.40.7-1.1-1.2-0.10.0
Social time0.91.23.0-1.21.31.2-1.50.6-0.6-1.70.00.5
Soleus weight2.16.29.12.9-3.0-3.03.0-2.62.90.91.71.2
Bone: stiffness2.84.48.62.5-2.6-2.72.9-1.82.01.60.70.0
Tibialis anterior weight5.017.029.35.3-5.4-5.35.4-3.73.72.91.70.1
Time to tail flick, vehicle, before self-admin0.10.10.40.2-0.2-0.60.5-0.00.00.3-0.4-0.4
Time to tail flick, vehicle, after self-admin1.21.32.5-1.21.40.7-1.41.4-1.6-0.5-0.8-0.7
Time to tail flick, test, before self-admin0.40.41.1-0.30.2-0.30.40.6-0.20.8-1.1-0.9
Time to tail flick, test, after self-admin2.82.95.6-1.51.80.5-0.82.4-2.01.2-2.2-1.9
Delta time to tail flick, vehicle, before/after SA0.20.20.6-0.20.40.5-0.80.2-0.7-0.20.1-0.1
Delta time to tail flick, test, before/after SA0.40.40.8-0.40.60.4-0.40.8-0.90.6-0.5-0.7
Tibia length0.20.61.40.00.0-0.00.0-0.80.9-1.20.91.2
Ambulatory time before self-admin0.30.31.40.1-0.20.20.5-0.21.20.40.50.9
Ambulatory time after self-admin2.12.34.31.5-1.9-2.02.1-0.81.42.0-0.1-0.3
Bone: tissue strength0.10.10.20.0-0.1-0.10.30.20.10.5-0.4-0.3
Total heroin consumption0.60.71.9-0.40.70.9-1.40.0-0.6-1.10.70.6
Bone: trabecular number0.60.91.61.1-1.1-1.21.1-0.91.10.20.70.4
Bone: trabecular spacing1.31.73.9-1.21.51.2-1.41.4-2.00.2-1.1-1.2
Bone: trabecular thickness4.85.79.62.2-2.2-2.01.6-3.12.9-1.22.92.5
Bone: trabecular tissue density0.10.10.30.0-0.1-0.20.3-0.30.5-0.10.20.4
Water consumed over 24 hours1.92.35.7-1.30.60.9-0.12.1-1.11.6-2.4-1.9
Number of responses in last shaping day0.50.51.61.0-1.3-0.40.8-0.80.50.40.3-0.0