Hub : Genes

Chmp7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Chmp7 0.04 0.04 7.1e-04 0.04 0.04 0.04 0.04 1.4e-04 2.7e-04 1.7e-04 1.5e-04
2 PL mRNA stability Chmp7 0.02 0.03 7.5e-03 0.01 0.01 0 0.01 1.7e-02 2.5e-02 8.7e-02 2.3e-02
3 PL gene expression Chmp7 0.09 0.09 2.8e-08 0.07 0.07 0.07 0.07 2.7e-08 3.9e-08 3.3e-08 3.6e-08
4 pVTA mRNA stability Chmp7 0.05 0.05 1.5e-03 0.04 0.03 0.03 0.03 3.6e-04 1.6e-03 1.3e-03 1.1e-03
5 Adipose gene expression Chmp7 0.37 0.19 0.0e+00 0.35 0.35 0.35 0.35 6.0e-40 7.2e-40 2.1e-40 4.4e-40
6 Brain gene expression Chmp7 0.04 0.04 9.6e-04 0.03 0.03 0.03 0.03 6.8e-04 6.3e-04 5.5e-04 8.2e-04
7 NAcc mRNA stability Chmp7 0.04 0.04 3.9e-05 0.03 0.03 0.03 0.03 8.1e-05 3.5e-05 3.5e-05 4.3e-05
8 pVTA gene expression Chmp7 0.04 0.04 6.9e-03 0.02 0.02 0.02 0.02 1.2e-02 1.6e-02 9.6e-03 1.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.32.22.41.51.51.51.5-1.51.61.51.4
Area under the delay curve0.10.10.1-0.3-0.3-0.3-0.30.3-0.4-0.3-0.2
BMI with tail0.51.62.1-1.4-1.4-1.2-1.31.2-1.2-1.2-1.1
BMI without tail0.00.00.0-0.2-0.2-0.0-0.10.0-0.1-0.00.1
Body weight0.72.93.4-1.9-1.9-1.7-1.81.7-1.6-1.7-1.6
Weight adjusted by age1.52.22.4-1.6-1.6-1.4-1.41.5-1.5-1.5-1.5
Bone surface0.61.11.31.11.11.11.1-1.11.11.01.0
Bone volume0.71.21.31.11.11.11.1-1.11.21.11.1
Breakpoint value in progressive ratio session0.10.20.2-0.4-0.4-0.5-0.50.4-0.4-0.3-0.3
Number of licking bursts0.00.00.0-0.1-0.1-0.10.10.0-0.1-0.00.1
Context. condit. distance diff. score0.81.01.10.90.91.01.0-1.01.01.01.1
Locomotion velocity, session 10.20.20.3-0.5-0.5-0.5-0.50.5-0.5-0.5-0.5
Locomotion distance, session 10.00.00.0-0.0-0.0-0.00.1-0.10.00.10.2
Locomotion velocity, session 20.00.00.10.30.30.20.1-0.20.20.20.1
Locomotion distance, session 20.00.00.00.20.20.10.1-0.10.20.10.0
Locomotion velocity, session 30.60.60.7-0.8-0.8-0.9-0.80.8-0.8-0.8-0.7
Locomotion distance, session 30.00.00.00.10.10.10.1-0.10.10.10.2
Stereotopy head waving bouts, day 30.70.81.0-0.8-0.8-1.0-1.00.9-1.0-0.9-0.9
Stereotopy head waving duration, day 32.42.93.1-1.6-1.6-1.8-1.71.7-1.8-1.7-1.7
Locomotion velocity, session 73.94.24.61.91.92.12.1-2.12.12.12.1
Locomotion distance, session 73.13.94.31.91.92.02.0-2.02.12.02.0
Stereotopy head waving bouts, day 71.31.41.9-0.9-0.9-1.2-1.31.3-1.2-1.3-1.4
Stereotopy head waving duration, day 71.92.32.6-1.4-1.4-1.5-1.51.6-1.5-1.6-1.6
Locomotion velocity, session 80.00.00.10.20.2-0.0-0.0-0.00.00.0-0.0
Locomotion distance, session 80.60.80.90.90.90.90.9-0.90.90.90.9
Degree of sensitization distance4.54.64.92.12.12.22.1-2.12.22.12.1
Degree of sensitization stereotypy0.91.01.3-0.8-0.8-1.0-1.01.0-1.0-1.1-1.2
Conditioned locomotion0.00.00.10.20.20.20.2-0.20.20.20.2
Cocaine response after cond. corrected0.30.40.5-0.7-0.7-0.5-0.60.6-0.6-0.6-0.6
Cocaine response after cond. not corrected0.20.20.4-0.6-0.6-0.4-0.40.5-0.5-0.4-0.4
Cocaine response before conditioning0.20.20.40.60.60.40.4-0.40.40.40.4
Saline control response0.10.10.20.40.40.40.3-0.40.40.40.3
Bone: connectivity density2.64.04.22.02.02.02.0-2.02.12.01.9
Bone: cortical apparent density0.00.10.10.20.20.30.3-0.30.30.30.3
Bone: cortical area0.00.00.0-0.1-0.10.00.0-0.00.10.0-0.0
Bone: cortical porosity1.11.21.3-1.0-1.0-1.1-1.11.1-1.1-1.1-1.2
Bone: cortical porosity0.60.70.8-0.7-0.7-0.9-0.90.8-0.9-0.9-0.9
Bone: cortical thickness0.00.00.00.00.00.00.0-0.00.00.00.0
Bone: cortical thickness0.00.00.00.10.10.00.0-0.00.00.00.0
Bone: cortical tissue density0.10.10.10.20.20.30.3-0.30.30.30.3
Condit. Reinf. active minus inactive responses0.60.70.9-1.0-1.0-0.8-0.70.8-0.9-0.8-0.7
Condit. Reinf. active-inactive response ratio2.42.63.0-1.6-1.6-1.6-1.51.6-1.7-1.6-1.5
Condit. Reinf. active responses0.00.00.0-0.2-0.2-0.1-0.10.1-0.1-0.1-0.0
Condit. Reinf. inactive responses2.53.03.21.71.71.71.7-1.81.81.71.7
Incentive salience index mean0.91.21.5-1.2-1.2-1.0-1.01.0-1.1-1.0-0.9
Condit. Reinf. lever presses0.40.60.9-1.0-1.0-0.7-0.70.7-0.7-0.7-0.6
Condit. Reinf. active minus inactive responses0.50.61.31.11.10.70.7-0.70.60.70.6
Condit. Reinf. active-inactive response ratio0.00.10.1-0.0-0.0-0.3-0.20.3-0.3-0.3-0.3
Condit. Reinf. active responses1.21.62.61.61.61.11.1-1.21.11.11.1
Condit. Reinf. inactive responses2.12.73.21.81.81.61.6-1.61.61.61.6
Condit. Reinf. lever presses0.20.30.50.70.70.40.5-0.50.50.40.4
Condit. Reinf. lever reinforcers received0.91.22.11.41.41.01.0-1.01.01.00.9
Conditioned reinforcement - actives1.01.61.71.21.21.31.3-1.31.31.31.3
Conditioned reinforcement - inactives3.14.54.82.02.02.22.2-2.12.12.12.1
Conditioned locomotion0.10.20.30.50.50.40.5-0.40.40.40.4
Patch foraging indifference point 0 sec1.83.44.02.02.01.91.8-1.81.81.81.7
Patch foraging indifference point AUC0.30.40.5-0.6-0.6-0.7-0.60.6-0.7-0.6-0.4
Delay disc. indifference point, 0s delay0.30.30.40.50.50.60.6-0.60.50.60.6
Delay disc. indifference point, 16s delay0.20.20.30.40.40.50.5-0.50.40.50.5
Delay disc. indifference point, 2s delay1.51.71.7-1.3-1.3-1.3-1.31.3-1.3-1.3-1.3
Delay disc. indifference point, 24s delay0.20.20.3-0.5-0.5-0.4-0.40.4-0.5-0.4-0.4
Delay disc. indifference point, 4s delay1.81.92.0-1.4-1.4-1.4-1.41.4-1.4-1.4-1.3
Delay disc. indifference point, 8s delay0.00.00.10.10.10.10.1-0.20.10.20.2
Indifference point function ln k0.00.00.00.20.20.20.1-0.10.10.1-0.0
Indifference point function log k0.00.00.00.20.20.20.1-0.10.10.1-0.0
Patch foraging total patch changes 0 sec1.32.52.91.71.71.61.5-1.51.61.51.5
Patch foraging total patch changes 12 sec0.60.81.01.01.00.80.9-0.90.80.90.9
Patch foraging total patch changes 18 sec1.32.02.31.51.51.31.3-1.41.31.41.5
Patch foraging total patch changes 24 sec0.00.00.0-0.1-0.1-0.1-0.10.1-0.2-0.00.0
Patch foraging total patch changes 6 sec0.20.30.40.60.60.50.5-0.50.50.60.5
Patch foraging time to switch 0 sec0.51.01.10.90.91.01.1-1.01.01.01.0
Patch foraging water rate 0 sec0.20.50.6-0.7-0.7-0.6-0.70.7-0.6-0.7-0.7
Patch foraging water rate 12 sec0.40.91.1-1.0-1.0-0.9-1.01.0-0.9-1.0-1.0
Patch foraging water rate 18 sec2.43.84.4-1.8-1.8-1.9-2.02.0-1.9-2.0-2.1
Patch foraging water rate 24 sec0.10.10.3-0.3-0.3-0.3-0.40.4-0.2-0.4-0.6
Patch foraging water rate 6 sec2.02.93.2-1.8-1.8-1.7-1.71.7-1.6-1.7-1.7
Seeking ratio, delayed vs. immediate footshock1.21.51.81.21.21.31.4-1.11.21.11.0
Distance traveled before self-admin0.71.01.2-1.1-1.1-0.9-0.81.0-1.0-1.0-1.0
Distance traveled after self-admin2.32.83.2-1.5-1.5-1.7-1.71.7-1.7-1.8-1.8
Extensor digitorum longus weight13.352.554.8-7.4-7.4-7.2-7.27.2-7.3-7.2-7.1
Bone: elastic displacement0.40.40.50.60.60.70.7-0.70.60.70.7
Bone: elastic work0.20.20.30.40.40.50.5-0.50.50.50.5
Bone: endosteal estimation0.10.10.2-0.5-0.5-0.3-0.30.3-0.3-0.3-0.4
Bone: endosteal perimeter0.00.10.2-0.4-0.4-0.2-0.20.2-0.2-0.2-0.3
Epididymis fat weight0.72.42.71.41.41.61.5-1.61.61.61.6
Delta time in closed arm before/after self-admin4.34.04.42.02.02.12.1-2.01.92.02.0
Delta time in open arm before/after self-admin0.10.10.3-0.2-0.2-0.5-0.20.2-0.2-0.2-0.3
Diff in mean of infusions in LGA sessions1.21.52.0-1.4-1.4-1.3-1.11.2-1.2-1.1-1.0
Delay discount exponential model param0.40.50.50.70.70.70.7-0.70.70.70.6
Extinction: sum of active levers before priming2.12.42.71.61.61.41.5-1.51.51.51.5
Active lever presses in extinction session 60.40.40.70.50.50.70.8-0.60.50.70.9
Bone: final force0.10.20.4-0.6-0.6-0.4-0.40.4-0.4-0.4-0.4
Bone: final moment0.10.20.3-0.6-0.6-0.3-0.30.4-0.3-0.3-0.3
Food consumed during 24 hour testing period0.20.30.40.50.50.50.6-0.60.50.60.6
Glucose0.00.00.1-0.3-0.3-0.00.10.0-0.1-0.00.0
Heart weight0.40.60.80.70.70.90.9-0.80.90.80.7
Delay discount hyperbolic model param0.50.60.70.80.80.80.8-0.80.80.80.7
Intermittent access intake day 1-15 change1.83.74.42.12.11.91.8-1.91.91.91.8
Intermittent access intake escalation1.93.94.52.12.11.91.9-1.91.91.91.9
Intermittent access intake escalation 21.61.82.41.51.51.31.3-1.31.31.31.3
Intermitt. access day 1 inactive lever presses0.00.00.00.10.10.10.2-0.10.10.10.1
Intermitt. access day 15 inactive lever presses0.00.00.10.00.00.30.3-0.20.20.20.2
Intermitt. access escalation Index0.10.10.2-0.4-0.4-0.3-0.30.3-0.2-0.3-0.2
Intermittent access day 1 total infusions0.00.00.0-0.1-0.1-0.00.20.0-0.0-0.0-0.0
Intermittent access day 15 total infusions1.72.63.01.61.61.61.7-1.61.61.61.6
Intermittent access terminal intake (last 3 days)1.11.51.81.31.31.21.3-1.21.21.21.2
Intermittent access total infusions1.21.41.71.21.21.21.3-1.21.21.21.2
Intermittent access day 1 locomotion0.00.00.00.10.10.10.1-0.10.10.10.1
Intermittent access day 15 total locomotion0.30.50.70.80.80.60.8-0.60.60.60.6
Intermittent access total locomotion0.10.10.20.40.40.30.4-0.30.30.30.3
Intermittent access standard deviation0.20.40.60.80.80.50.5-0.60.50.50.5
Left kidney weight0.00.20.2-0.4-0.4-0.4-0.40.4-0.3-0.4-0.4
Right kidney weight0.00.10.1-0.3-0.3-0.2-0.30.2-0.1-0.2-0.2
Cocaine induced anxiety0.00.00.0-0.2-0.2-0.1-0.00.1-0.1-0.1-0.0
Post-drug Anxiety0.80.91.00.90.90.91.0-1.00.91.01.0
Baseline Anxiety0.40.50.60.70.70.60.7-0.70.60.70.7
Tail length0.51.92.11.31.31.41.3-1.41.41.41.4
Length with tail0.00.20.2-0.5-0.5-0.4-0.40.4-0.4-0.4-0.4
Length without tail2.27.27.8-2.8-2.8-2.6-2.62.7-2.6-2.7-2.7
Times rat made contact with spout0.50.60.70.80.80.70.8-0.80.70.80.8
Lifetime Intake0.70.81.10.90.90.91.1-0.90.90.90.9
Liver weight, left2.03.33.6-1.9-1.9-1.8-1.91.8-1.8-1.7-1.7
Liver weight, right0.50.91.1-0.9-0.9-0.9-1.00.9-0.9-0.9-0.9
Locomotor activity1.42.22.7-1.4-1.4-1.5-1.41.6-1.6-1.6-1.6
Locomotor testing distance0.10.10.20.40.40.30.3-0.20.20.20.2
Locomotor testing rearing0.20.30.50.70.70.60.5-0.50.50.50.5
Locomotion in novel chamber0.50.60.80.80.80.90.8-0.80.80.80.7
Locomotion in novel chamber post-restriction0.60.91.3-0.9-0.9-0.9-0.81.0-0.9-1.0-1.1
Fecal boli incidents, locomotor time 11.11.51.8-1.2-1.2-1.3-1.31.2-1.3-1.2-1.2
Change in fecal boli incidents, locomotor task0.30.30.4-0.6-0.6-0.4-0.40.5-0.5-0.5-0.5
Time >=10cm from walls, locomotor time 10.80.91.10.80.80.90.9-1.00.91.01.1
Bouts of movement, locomotor time 15.05.75.9-2.4-2.4-2.4-2.42.4-2.4-2.4-2.3
Total resting periods, locomotor time 14.95.55.7-2.4-2.4-2.4-2.42.3-2.4-2.3-2.2
Rest time, locomotor task time 12.02.52.8-1.7-1.7-1.6-1.61.5-1.6-1.5-1.5
Distance moved, locomotor task time 12.43.53.82.02.01.81.8-1.81.81.81.9
Vertical activity count, locomotor time 10.51.31.41.21.21.21.2-1.11.11.11.1
Time >=10cm from walls, locomotor time 20.30.50.5-0.7-0.7-0.6-0.60.7-0.6-0.7-0.7
Bouts of movement, locomotor time 23.25.25.4-2.2-2.2-2.3-2.32.3-2.3-2.3-2.3
Total resting periods, locomotor time 23.25.55.7-2.3-2.3-2.4-2.42.4-2.3-2.4-2.4
Rest time, locomotor task time 20.91.11.3-1.2-1.2-1.0-1.01.0-1.0-1.0-1.0
Distance moved, locomotor task time 23.13.74.02.02.01.91.9-1.91.91.91.9
Vertical activity count, locomotor time 20.40.50.60.70.70.70.7-0.70.70.70.7
Light reinforcement 12.25.45.72.42.42.32.3-2.32.42.32.3
Light reinforcement 20.71.11.40.80.81.11.1-1.11.11.11.2
Bone: marrow area0.00.10.1-0.3-0.3-0.2-0.20.2-0.1-0.2-0.2
Bone: maximum diameter0.40.70.8-0.9-0.9-0.8-0.80.8-0.7-0.8-0.8
Bone: maximum force0.30.50.6-0.7-0.7-0.7-0.70.7-0.7-0.7-0.7
Bone: maximum moment0.20.30.4-0.6-0.6-0.5-0.50.5-0.5-0.5-0.6
Mean time between licks in bursts1.02.42.81.41.41.61.7-1.61.61.61.7
Mean num. licks in bursts0.30.40.60.80.80.60.5-0.60.60.60.5
Cd content in liver1.21.41.5-1.2-1.2-1.2-1.11.2-1.2-1.2-1.1
Co content in liver5.36.16.6-2.6-2.6-2.5-2.42.5-2.5-2.4-2.4
Cu content in liver0.50.60.8-0.9-0.9-0.7-0.70.7-0.8-0.7-0.7
Fe content in liver1.72.02.11.41.41.41.4-1.41.41.41.4
K content in liver1.11.11.11.01.01.11.1-1.01.01.11.1
Mg content in liver2.72.82.91.71.71.71.7-1.71.71.71.7
Mn content in liver2.73.03.51.91.91.71.7-1.71.71.71.7
Na content in liver1.01.11.1-1.0-1.0-1.0-1.01.0-1.0-1.0-1.0
Rb content in liver0.00.00.10.30.30.20.2-0.20.20.20.1
Se content in liver0.91.11.21.11.11.11.1-1.11.11.11.0
Sr content in liver0.00.00.00.10.10.10.1-0.10.00.10.2
Zn content in liver0.10.10.20.20.20.30.4-0.30.30.40.4
Bone: minimum diameter0.10.30.4-0.7-0.7-0.4-0.50.5-0.4-0.5-0.5
Time in familiar zone, hab. session 10.00.00.0-0.1-0.1-0.1-0.10.1-0.1-0.1-0.2
Time in novel zone, hab. session 11.21.21.3-1.1-1.1-1.1-1.11.1-1.2-1.1-1.1
Total zone transitions, hab. session 10.20.30.4-0.5-0.5-0.6-0.60.5-0.6-0.6-0.5
Total locomotion distance, hab. session 10.00.00.00.10.1-0.1-0.0-0.0-0.00.00.1
Locomotion velocity, hab. session 10.10.10.20.40.40.20.3-0.30.30.30.4
Time in familiar zone, hab. session 22.02.22.3-1.5-1.5-1.5-1.51.5-1.4-1.5-1.5
Time in novel zone, hab. session 20.80.80.91.01.00.90.9-0.90.80.90.9
Total zone transitions, hab. session 21.51.92.1-1.4-1.4-1.4-1.31.3-1.4-1.3-1.3
Total locomotion distance, hab. session 20.30.40.5-0.7-0.7-0.6-0.60.6-0.6-0.6-0.5
Locomotion velocity, hab. session 20.60.81.0-1.0-1.0-0.9-0.90.9-0.9-0.9-0.8
Novel to familiar place preference ratio1.61.71.81.31.31.31.3-1.31.31.31.3
Novelty place preference1.31.41.41.21.21.21.2-1.11.11.21.2
Time in novel zone, NPP test0.70.70.80.90.90.80.8-0.80.80.80.9
Total zone transitions, NPP test0.10.20.20.40.40.40.4-0.40.40.40.5
Total locomotion distance, NPP test2.53.53.61.91.91.81.9-1.91.81.91.9
Locomotion velocity, NPP test2.43.43.61.91.91.81.8-1.91.81.91.9
Intraocular pressure0.50.70.70.80.80.80.9-0.80.70.80.9
Delta distance traveled before/after self-admin2.83.03.6-1.4-1.4-1.9-1.91.7-1.7-1.8-1.8
Delta ambulatory time before/after self-admin2.53.13.5-1.5-1.5-1.9-1.91.8-1.7-1.8-1.9
Parametrial fat weight2.14.95.42.32.32.22.2-2.22.32.22.0
Pavlov. Cond. lever latency0.00.00.0-0.1-0.10.00.0-0.0-0.00.00.0
Pavlov. Cond. magazine entry latency0.00.00.10.30.30.10.1-0.20.20.20.2
Pavlov. Cond. change in total contacts1.11.21.4-1.0-1.0-1.2-1.21.1-1.1-1.1-1.1
Pavlov. Cond. index score0.10.10.1-0.2-0.2-0.3-0.30.3-0.3-0.3-0.3
Pavlov. Cond. latency score0.00.00.10.00.0-0.2-0.20.2-0.1-0.2-0.2
Pavlov. Cond. lever contacts0.00.00.00.10.10.00.1-0.10.10.10.1
Pavlov. Cond. magazine entry number0.40.40.50.50.50.70.7-0.70.70.70.7
Pavlov. Cond. intertrial magazine entries0.10.10.20.30.30.40.4-0.40.30.40.4
Pavlov. Cond. lever-magazine prob. diff.0.20.20.3-0.4-0.4-0.5-0.50.5-0.4-0.5-0.5
Pavlov. Cond. response bias0.10.20.2-0.3-0.3-0.5-0.50.4-0.4-0.4-0.5
Pavlov. Cond. lever latency0.40.50.60.60.60.80.7-0.70.70.70.7
Pavlov. Cond. magazine entry latency0.10.10.10.10.10.20.3-0.30.20.30.3
Pavlov. Cond. change in total contacts1.21.82.1-1.3-1.3-1.4-1.31.4-1.4-1.4-1.3
Pavlov. Cond. index score0.40.50.6-0.8-0.8-0.8-0.60.7-0.8-0.7-0.6
Pavlov. Cond. latency score0.30.40.6-0.8-0.8-0.6-0.50.6-0.6-0.6-0.5
Pavlov. Cond. lever contacts0.20.20.3-0.4-0.4-0.6-0.40.5-0.5-0.5-0.4
Pavlov. Cond. magazine entry number0.00.00.10.00.0-0.1-0.20.2-0.1-0.2-0.2
Pavlov. Cond. intertrial magazine entries5.27.98.22.82.82.82.8-2.82.92.82.8
Pavlov. Cond. lever-magazine prob. diff.0.50.70.8-0.9-0.9-0.9-0.70.8-0.9-0.8-0.7
Pavlov. Cond. response bias0.20.30.4-0.5-0.5-0.6-0.50.5-0.6-0.5-0.5
Time in closed arm before self-admin1.51.92.3-1.3-1.3-1.5-1.51.3-1.2-1.4-1.5
Time in closed arm after self-admin0.00.00.0-0.1-0.1-0.1-0.10.1-0.1-0.2-0.2
Time in open arm before self-admin0.00.00.0-0.2-0.20.10.10.1-0.2-0.00.1
Time in open arm after self-admin0.00.00.10.20.20.00.1-0.10.00.10.2
Bone: periosteal estimation0.00.10.2-0.5-0.5-0.2-0.20.3-0.2-0.3-0.3
Bone: periosteal perimeter0.00.00.1-0.3-0.3-0.1-0.20.2-0.1-0.2-0.2
Bone: post-yield work0.20.20.30.60.60.50.4-0.50.50.40.4
Progressive ratio test 1 active lever presses0.10.10.2-0.4-0.4-0.3-0.30.3-0.3-0.3-0.3
Progressive ratio test 1 breakpoint0.20.20.3-0.5-0.5-0.4-0.30.4-0.4-0.4-0.4
Progressive ratio test 1 inactive lever presses0.81.11.70.80.81.11.3-1.11.11.11.1
Progressive ratio test 2 active lever presses0.00.00.10.20.20.20.3-0.20.20.20.2
Progressive ratio test 2 breakpoint0.00.00.10.10.10.20.3-0.10.10.10.1
Progressive ratio test 2 inactive lever presses0.30.40.60.50.50.70.8-0.60.60.60.6
Incentive Sensitization - Responses0.20.40.40.60.60.60.6-0.60.60.60.6
Incentive Sensitization - Breakpoint0.40.50.50.70.70.70.7-0.70.70.70.7
Sum of active levers in priming session hrs 5-60.10.10.10.30.30.30.3-0.30.10.30.3
Progressive ratio0.00.00.0-0.1-0.1-0.1-0.10.1-0.1-0.1-0.1
Food seeking constrained by brief footshock2.22.73.0-1.7-1.7-1.6-1.51.6-1.6-1.6-1.6
Seeking ratio, punishment vs. effort0.71.01.1-1.0-1.0-1.0-0.91.0-1.0-1.0-1.0
Retroperitoneal fat weight0.10.50.70.80.80.70.6-0.70.70.70.7
Reaction time number correct0.50.91.1-0.9-0.9-1.0-1.01.0-0.9-1.0-1.0
Reaction time mean minus median0.10.20.3-0.6-0.6-0.5-0.30.4-0.4-0.4-0.4
Reaction time mean minus median AUC0.00.10.2-0.5-0.5-0.4-0.30.3-0.3-0.3-0.3
Reaction time num false alarms0.10.10.2-0.0-0.0-0.3-0.30.3-0.2-0.3-0.5
Reaction time num false alarms AUC0.00.00.10.00.0-0.2-0.20.2-0.1-0.2-0.4
Reaction time trials correct on left0.50.91.1-0.9-0.9-1.0-1.01.0-0.9-1.0-1.0
Reaction time trials on left0.40.70.8-0.8-0.8-0.9-0.90.8-0.7-0.9-0.9
Reaction time mean0.20.30.5-0.7-0.7-0.6-0.50.5-0.6-0.5-0.4
Reaction time mean AUC0.40.60.8-0.9-0.9-0.8-0.70.7-0.8-0.7-0.6
Median of all reaction times0.20.30.4-0.7-0.7-0.5-0.50.5-0.5-0.5-0.4
Reaction time omissions1.72.52.71.61.61.61.6-1.61.51.61.6
Reaction time false alarm rate0.10.20.30.50.50.40.4-0.30.40.30.2
Reaction time premature initiation rate2.02.72.8-1.7-1.7-1.5-1.61.7-1.7-1.6-1.7
Reaction time premature initiations2.23.94.2-2.0-2.0-1.9-2.02.0-1.9-2.0-2.0
Std. dev. reaction times0.10.20.4-0.6-0.6-0.5-0.40.4-0.5-0.4-0.4
Reaction time trials completed0.40.70.8-0.8-0.8-0.9-0.90.8-0.7-0.9-0.9
Reaction time trials AUC0.30.60.7-0.8-0.8-0.9-0.80.8-0.7-0.8-0.9
Run reversals in cocaine runway, females2.92.93.31.61.61.71.7-1.81.81.81.8
Run reversals in cocaine runway, males2.12.12.7-1.4-1.4-1.4-1.61.4-1.4-1.4-1.4
Latency to leave start box in cocaine runway0.40.40.5-0.7-0.7-0.7-0.50.7-0.6-0.7-0.7
Latency to leave start box in cocaine runway, F1.21.41.5-1.2-1.2-1.2-1.21.2-1.2-1.2-1.2
Latency to leave start box in cocaine runway, M0.10.10.30.30.30.30.6-0.30.30.30.3
Std. dev. time between licks in bursts1.11.51.81.01.01.31.3-1.31.31.31.3
Total sessions with >9 infusions0.10.10.2-0.4-0.4-0.2-0.20.3-0.2-0.2-0.2
Short access day 1 total inactive lever presses0.10.10.20.30.30.50.5-0.40.40.40.4
Short access day 10 total inactive lever presses0.10.30.40.40.40.50.6-0.50.50.50.5
Short access day 1 total infusions0.10.10.1-0.4-0.4-0.2-0.20.3-0.2-0.3-0.3
Short access day 10 total infusions0.30.40.5-0.7-0.7-0.6-0.50.6-0.6-0.6-0.6
Short access total infusions0.00.10.1-0.3-0.3-0.2-0.10.2-0.2-0.2-0.2
Short access day 1 locomotion0.81.01.1-1.0-1.0-1.0-0.91.0-1.0-1.0-1.0
Short access day 10 total locomotion0.00.00.00.00.00.10.0-0.10.10.10.1
Short access total locomotion0.10.20.2-0.5-0.5-0.3-0.40.4-0.3-0.4-0.4
One hour access (0.3 mA shock)0.70.91.01.01.00.90.9-0.90.90.90.9
Compulsive drug intake0.70.81.21.11.10.90.7-0.90.90.90.9
One hour access (shock baseline)0.00.00.0-0.1-0.1-0.00.10.0-0.0-0.0-0.0
Social response proportion0.10.10.2-0.2-0.2-0.3-0.40.3-0.3-0.3-0.4
Social responses1.21.62.21.51.51.21.1-1.21.21.21.2
Social time0.50.60.90.90.90.80.7-0.70.80.70.6
Soleus weight1.33.84.0-2.0-2.0-1.9-1.91.9-2.0-1.9-1.9
Bone: stiffness0.71.11.2-1.1-1.1-1.0-1.11.1-1.0-1.1-1.1
Tibialis anterior weight8.629.331.2-5.6-5.6-5.4-5.35.4-5.4-5.3-5.2
Time to tail flick, vehicle, before self-admin0.90.91.40.90.91.01.2-0.90.81.01.0
Time to tail flick, vehicle, after self-admin1.72.33.1-1.8-1.8-1.4-1.41.5-1.5-1.4-1.4
Time to tail flick, test, before self-admin2.82.93.11.71.71.71.7-1.71.71.71.8
Time to tail flick, test, after self-admin2.42.52.91.61.61.71.5-1.61.51.61.5
Delta time to tail flick, vehicle, before/after SA0.30.30.4-0.6-0.6-0.5-0.60.5-0.5-0.5-0.5
Delta time to tail flick, test, before/after SA0.00.00.00.10.10.20.1-0.10.10.10.1
Tibia length1.23.33.91.71.71.91.8-1.92.01.81.8
Ambulatory time before self-admin0.30.40.5-0.7-0.7-0.6-0.50.6-0.7-0.6-0.6
Ambulatory time after self-admin4.95.86.3-2.2-2.2-2.5-2.52.4-2.4-2.5-2.5
Bone: tissue strength0.10.10.10.30.30.30.2-0.20.30.20.2
Total heroin consumption0.60.80.9-0.9-0.9-0.9-0.90.8-0.7-0.8-0.8
Bone: trabecular number2.43.94.22.02.02.02.0-1.92.01.91.9
Bone: trabecular spacing2.43.13.4-1.9-1.9-1.8-1.71.8-1.7-1.7-1.7
Bone: trabecular thickness1.11.31.41.11.11.21.2-1.21.21.21.2
Bone: trabecular tissue density1.31.92.2-1.2-1.2-1.4-1.41.4-1.5-1.4-1.4
Water consumed over 24 hours1.31.81.9-1.4-1.4-1.4-1.31.3-1.3-1.3-1.2
Number of responses in last shaping day0.70.81.1-1.1-1.1-0.8-0.80.9-0.8-0.8-0.8