Hub : Genes

LOC120097012

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC120097012	0.04	0.03	3.1e-06	0.04	0.05	0.03	0.05	5.8e-06	1.1e-06	8.9e-05	4.8e-06
2	pVTA	gene expression	LOC120097012	0.09	0.06	1.1e-03	0.09	0.08	0.03	0.07	1.4e-04	2.3e-04	1.3e-02	7.0e-04
3	BLA	gene expression	LOC120097012	0.05	0.04	8.6e-03	0.03	0.03	0.05	0.03	1.2e-02	1.5e-02	1.4e-03	1.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.1	0.2	0.3	0.4	0.2	-0.5
Area under the delay curve	4.6	4.8	8.2	2.1	-2.9	-1.3
BMI with tail	0.6	1.9	3.8	1.3	-1.9	0.2
BMI without tail	0.6	1.2	1.7	-1.2	0.6	1.3
Body weight	1.1	4.7	6.8	2.6	-2.6	-0.9
Weight adjusted by age	2.7	3.0	3.5	1.9	-1.5	-1.9
Bone surface	0.2	0.4	0.7	0.8	-0.0	-0.7
Bone volume	0.3	0.5	1.1	1.1	-0.4	-0.6
Breakpoint value in progressive ratio session	1.2	1.3	4.0	-0.1	0.0	2.0
Number of licking bursts	0.1	0.1	0.2	-0.2	-0.4	0.2
Context. condit. distance diff. score	1.1	1.3	2.3	-1.5	0.4	1.2
Locomotion velocity, session 1	0.8	0.8	1.1	1.1	-0.7	-0.9
Locomotion distance, session 1	1.6	2.0	4.6	1.1	-0.6	-2.1
Locomotion velocity, session 2	1.3	1.5	2.3	1.5	-1.2	-0.9
Locomotion distance, session 2	0.8	1.1	2.1	1.1	-0.2	-1.4
Locomotion velocity, session 3	0.6	0.7	1.2	0.6	-0.7	-1.1
Locomotion distance, session 3	1.2	1.4	3.3	0.4	-0.8	-1.8
Stereotopy head waving bouts, day 3	1.0	1.2	1.9	-1.2	1.4	0.6
Stereotopy head waving duration, day 3	0.0	0.1	0.1	0.1	0.1	-0.4
Locomotion velocity, session 7	0.2	0.2	0.4	-0.6	0.2	0.5
Locomotion distance, session 7	1.6	2.1	2.6	-1.6	1.2	1.5
Stereotopy head waving bouts, day 7	2.1	2.3	2.7	1.6	-1.4	-1.6
Stereotopy head waving duration, day 7	2.6	3.2	4.2	1.6	-1.7	-2.0
Locomotion velocity, session 8	0.6	0.7	0.9	0.8	-0.9	-0.8
Locomotion distance, session 8	0.1	0.1	0.2	-0.1	-0.2	-0.4
Degree of sensitization distance	6.4	6.4	9.4	-2.3	2.2	3.1
Degree of sensitization stereotypy	2.6	2.8	3.1	1.8	-1.7	-1.5
Conditioned locomotion	0.2	0.2	0.5	-0.3	0.1	0.7
Cocaine response after cond. corrected	1.3	1.5	2.4	-1.4	0.3	1.6
Cocaine response after cond. not corrected	1.0	1.1	1.7	-1.3	0.3	1.3
Cocaine response before conditioning	0.8	0.9	1.7	1.0	-0.4	-1.3
Saline control response	0.2	0.3	0.8	-0.3	0.9	0.0
Bone: connectivity density	0.4	0.6	1.3	-0.6	1.1	0.1
Bone: cortical apparent density	0.4	0.6	1.7	-1.3	0.2	0.1
Bone: cortical area	0.5	0.7	1.1	1.0	-1.1	-0.4
Bone: cortical porosity	2.4	2.6	3.3	1.8	-1.5	-1.4
Bone: cortical porosity	1.9	2.1	2.6	1.5	-1.2	-1.6
Bone: cortical thickness	0.5	0.8	1.5	0.8	-1.2	-0.2
Bone: cortical thickness	0.6	0.7	1.6	0.3	-1.3	-0.7
Bone: cortical tissue density	0.5	0.6	1.8	-1.3	0.2	0.2
Condit. Reinf. active minus inactive responses	1.0	1.2	1.9	1.4	-0.7	-1.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.4	0.6	0.1
Condit. Reinf. active responses	1.3	1.6	2.5	1.6	-1.0	-1.2
Condit. Reinf. inactive responses	0.9	1.1	1.3	1.1	-0.8	-1.1
Incentive salience index mean	3.0	3.6	6.1	2.5	-1.8	-1.3
Condit. Reinf. lever presses	3.8	5.1	8.5	2.9	-2.3	-1.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.4	0.2	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	-0.1	-0.1	-0.7
Condit. Reinf. active responses	0.2	0.3	0.7	-0.3	-0.0	-0.8
Condit. Reinf. inactive responses	0.3	0.4	0.6	-0.7	0.8	0.4
Condit. Reinf. lever presses	2.1	2.8	6.2	1.2	-0.9	-2.5
Condit. Reinf. lever reinforcers received	0.2	0.3	1.0	-0.1	-0.2	-1.0
Conditioned reinforcement - actives	7.7	7.7	8.3	-2.8	2.9	2.7
Conditioned reinforcement - inactives	3.4	3.9	5.2	-1.7	1.9	2.3
Conditioned locomotion	4.1	5.0	6.2	-2.4	1.7	2.5
Patch foraging indifference point 0 sec	0.5	0.7	1.4	1.2	-0.5	-0.8
Patch foraging indifference point AUC	1.0	1.1	2.8	-1.7	0.7	0.3
Delay disc. indifference point, 0s delay	0.5	0.5	0.7	0.7	-0.8	-0.6
Delay disc. indifference point, 16s delay	1.0	1.1	2.2	1.0	-1.5	-0.1
Delay disc. indifference point, 2s delay	1.7	1.9	2.6	1.1	-1.3	-1.6
Delay disc. indifference point, 24s delay	1.8	1.7	3.8	0.9	-1.9	0.7
Delay disc. indifference point, 4s delay	4.8	5.1	7.5	2.3	-2.7	-1.6
Delay disc. indifference point, 8s delay	5.5	5.7	9.4	2.3	-3.1	-1.6
Indifference point function ln k	2.1	2.9	5.4	2.3	-1.7	-0.7
Indifference point function log k	2.1	2.9	5.4	2.3	-1.7	-0.7
Patch foraging total patch changes 0 sec	0.8	1.3	2.2	1.5	-1.0	-1.0
Patch foraging total patch changes 12 sec	0.1	0.1	0.4	0.0	-0.0	-0.6
Patch foraging total patch changes 18 sec	0.3	0.3	0.9	-1.0	0.3	-0.1
Patch foraging total patch changes 24 sec	0.8	0.9	2.8	0.1	-0.1	-1.7
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	-0.3	-0.1	0.0
Patch foraging time to switch 0 sec	0.2	0.4	0.5	-0.4	0.7	0.7
Patch foraging water rate 0 sec	1.5	2.4	3.1	1.4	-1.8	-1.4
Patch foraging water rate 12 sec	2.8	4.2	7.8	1.5	-1.6	-2.8
Patch foraging water rate 18 sec	7.1	9.6	12.1	2.6	-3.2	-3.5
Patch foraging water rate 24 sec	0.7	1.0	1.3	1.0	-1.2	-0.8
Patch foraging water rate 6 sec	2.0	3.0	5.6	1.3	-1.3	-2.4
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	0.8	0.9	-0.6	0.9
Distance traveled before self-admin	0.2	0.2	0.5	0.1	0.2	0.7
Distance traveled after self-admin	0.4	0.4	1.1	-0.2	0.1	1.1
Extensor digitorum longus weight	6.1	24.1	31.0	4.8	-5.6	-4.3
Bone: elastic displacement	0.3	0.3	0.6	-0.3	0.8	-0.5
Bone: elastic work	0.6	0.8	1.2	1.1	-0.3	-1.1
Bone: endosteal estimation	0.1	0.2	0.5	0.7	-0.0	0.1
Bone: endosteal perimeter	0.1	0.1	0.2	0.4	0.4	0.0
Epididymis fat weight	0.1	0.1	0.3	-0.3	0.3	0.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.3	-0.4	0.1
Delta time in open arm before/after self-admin	1.8	1.8	2.9	-1.1	1.1	1.7
Diff in mean of infusions in LGA sessions	0.9	1.0	1.7	1.3	-1.0	0.3
Delay discount exponential model param	5.6	5.8	9.6	-2.3	3.1	1.7
Extinction: sum of active levers before priming	1.2	1.2	2.8	-0.7	0.5	1.7
Active lever presses in extinction session 6	0.9	0.8	1.2	-0.7	1.1	0.9
Bone: final force	1.1	1.8	2.7	1.7	-1.6	-0.4
Bone: final moment	1.2	1.9	3.0	1.7	-1.5	-0.7
Food consumed during 24 hour testing period	0.1	0.1	0.2	0.4	-0.1	-0.5
Glucose	0.1	0.2	0.4	0.1	-0.5	-0.6
Heart weight	0.2	0.3	0.3	0.6	-0.5	-0.5
Delay discount hyperbolic model param	5.6	5.9	9.1	-2.3	3.0	1.8
Intermittent access intake day 1-15 change	1.9	1.9	2.9	-0.9	1.4	1.7
Intermittent access intake escalation	2.8	2.7	4.5	-1.1	1.6	2.1
Intermittent access intake escalation 2	1.6	1.6	1.8	-1.1	1.3	1.3
Intermitt. access day 1 inactive lever presses	2.5	2.7	4.5	-1.3	1.4	2.1
Intermitt. access day 15 inactive lever presses	1.2	1.3	3.5	-0.3	0.5	1.9
Intermitt. access escalation Index	0.6	0.6	1.1	-0.6	0.4	-1.0
Intermittent access day 1 total infusions	0.6	0.6	1.3	-1.1	0.5	0.6
Intermittent access day 15 total infusions	3.7	4.1	4.5	-2.1	1.9	2.1
Intermittent access terminal intake (last 3 days)	2.9	3.2	4.3	-2.1	1.7	1.5
Intermittent access total infusions	2.9	3.2	4.4	-1.9	1.3	2.1
Intermittent access day 1 locomotion	0.1	0.1	0.1	-0.1	-0.4	0.2
Intermittent access day 15 total locomotion	2.4	2.6	3.7	-1.5	1.4	1.9
Intermittent access total locomotion	1.1	1.3	2.9	-0.8	0.5	1.7
Intermittent access standard deviation	0.8	0.8	1.2	-0.6	1.1	0.9
Left kidney weight	2.6	7.3	9.1	3.0	-2.6	-2.4
Right kidney weight	3.0	8.4	9.1	2.9	-2.8	-3.0
Cocaine induced anxiety	1.7	2.0	4.4	1.0	-0.7	-2.1
Post-drug Anxiety	0.8	0.9	1.7	1.3	-0.8	-0.7
Baseline Anxiety	0.8	0.8	2.3	0.4	-0.1	1.5
Tail length	0.2	0.6	1.1	-0.8	1.0	0.0
Length with tail	0.4	1.4	2.5	1.6	-0.8	-1.0
Length without tail	2.9	6.4	10.6	3.3	-2.4	-1.6
Times rat made contact with spout	0.3	0.4	0.6	0.8	-0.6	-0.5
Lifetime Intake	2.1	2.4	2.9	-1.7	1.3	1.7
Liver weight, left	1.9	3.1	4.1	1.6	-2.0	-1.6
Liver weight, right	0.2	0.3	0.7	0.5	-0.9	0.0
Locomotor activity	4.7	7.4	9.9	3.1	-2.3	-2.6
Locomotor testing distance	1.4	2.3	3.7	1.9	-0.8	-1.6
Locomotor testing rearing	1.0	1.6	2.7	1.5	0.2	-1.6
Locomotion in novel chamber	0.9	1.2	1.8	0.9	-1.0	-1.3
Locomotion in novel chamber post-restriction	1.5	1.8	3.3	1.0	-1.1	-1.8
Fecal boli incidents, locomotor time 1	2.8	3.1	6.9	0.5	-1.5	-2.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.2	0.4	0.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.5	0.1	-0.2
Bouts of movement, locomotor time 1	1.6	1.7	2.8	1.4	-1.7	-0.6
Total resting periods, locomotor time 1	0.9	1.0	2.0	0.9	-1.4	-0.4
Rest time, locomotor task time 1	1.2	1.4	2.5	0.7	-1.6	-1.1
Distance moved, locomotor task time 1	1.6	1.8	2.9	-1.0	1.7	1.2
Vertical activity count, locomotor time 1	0.7	0.8	1.9	-0.6	1.4	0.2
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.5	0.5	0.1	0.7
Bouts of movement, locomotor time 2	2.1	2.3	4.2	1.6	-2.0	-0.4
Total resting periods, locomotor time 2	2.6	2.8	4.9	1.7	-2.2	-0.7
Rest time, locomotor task time 2	2.3	2.6	3.3	1.1	-1.8	-1.8
Distance moved, locomotor task time 2	1.3	1.5	2.3	-0.8	1.3	1.5
Vertical activity count, locomotor time 2	1.1	1.2	1.5	-0.9	1.2	1.2
Light reinforcement 1	0.5	0.9	1.2	0.9	-0.8	-1.1
Light reinforcement 2	0.2	0.3	0.6	-0.8	0.2	0.5
Bone: marrow area	0.1	0.2	0.5	0.7	0.1	0.1
Bone: maximum diameter	0.0	0.1	0.1	0.3	-0.3	0.3
Bone: maximum force	1.2	2.0	3.2	1.8	-1.6	-0.6
Bone: maximum moment	1.3	2.2	3.5	1.9	-1.5	-0.9
Mean time between licks in bursts	2.4	3.3	4.3	-1.9	2.1	1.4
Mean num. licks in bursts	0.1	0.2	0.3	0.6	0.0	-0.5
Cd content in liver	0.1	0.2	0.2	-0.1	0.5	0.5
Co content in liver	0.9	1.0	1.8	1.1	-1.3	-0.2
Cu content in liver	1.4	1.7	2.0	1.4	-1.1	-1.3
Fe content in liver	0.5	0.5	0.8	-0.6	0.9	0.7
K content in liver	0.7	0.7	1.4	-1.2	0.6	0.5
Mg content in liver	1.4	1.5	1.9	-1.4	1.1	1.1
Mn content in liver	0.9	1.0	1.3	-1.0	0.8	1.2
Na content in liver	3.7	3.9	5.6	2.4	-1.9	-1.6
Rb content in liver	3.1	3.8	5.0	-1.7	1.8	2.2
Se content in liver	0.6	0.7	1.8	0.4	0.4	1.4
Sr content in liver	1.2	1.1	2.2	-1.0	1.5	0.3
Zn content in liver	2.6	2.9	4.3	2.1	-1.5	-1.5
Bone: minimum diameter	0.4	0.7	1.5	1.2	-0.7	-0.3
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.1	-0.1	-0.0
Time in novel zone, hab. session 1	0.0	0.0	0.0	0.1	-0.1	-0.1
Total zone transitions, hab. session 1	1.8	2.5	4.4	1.2	-1.3	-2.1
Total locomotion distance, hab. session 1	0.4	0.5	1.3	0.4	-0.4	-1.1
Locomotion velocity, hab. session 1	0.6	0.8	1.5	0.8	-0.6	-1.2
Time in familiar zone, hab. session 2	0.7	0.7	1.1	-0.8	0.7	1.1
Time in novel zone, hab. session 2	0.7	0.7	1.7	0.6	-0.4	-1.3
Total zone transitions, hab. session 2	3.0	3.8	5.6	1.7	-1.7	-2.4
Total locomotion distance, hab. session 2	2.0	2.6	3.8	1.4	-1.4	-1.9
Locomotion velocity, hab. session 2	2.5	3.4	4.3	1.8	-1.7	-2.1
Novel to familiar place preference ratio	0.3	0.3	0.4	-0.2	0.6	0.7
Novelty place preference	0.2	0.2	0.3	0.1	0.5	0.5
Time in novel zone, NPP test	0.2	0.2	0.2	0.2	0.5	0.5
Total zone transitions, NPP test	1.7	2.4	3.8	1.4	-1.3	-2.0
Total locomotion distance, NPP test	0.2	0.3	0.8	0.2	0.3	-0.9
Locomotion velocity, NPP test	0.2	0.3	1.0	0.1	0.2	-1.0
Intraocular pressure	2.7	3.8	7.0	-2.0	2.7	0.8
Delta distance traveled before/after self-admin	0.0	0.0	0.1	-0.1	-0.0	0.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	-0.3	0.2	0.3
Parametrial fat weight	3.0	5.9	6.1	-2.5	2.4	2.4
Pavlov. Cond. lever latency	1.8	2.3	3.6	-1.9	1.7	0.5
Pavlov. Cond. magazine entry latency	0.7	0.9	1.7	1.3	-0.8	0.6
Pavlov. Cond. change in total contacts	3.2	3.4	6.4	2.5	-1.9	-0.3
Pavlov. Cond. index score	3.7	4.7	7.6	2.8	-2.4	-0.6
Pavlov. Cond. latency score	3.0	3.9	6.5	2.5	-2.2	-0.6
Pavlov. Cond. lever contacts	3.0	3.5	5.9	2.4	-2.1	-0.4
Pavlov. Cond. magazine entry number	1.6	2.0	3.7	-1.9	1.5	0.2
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.7	0.6	-0.6	-1.3
Pavlov. Cond. lever-magazine prob. diff.	4.2	5.2	8.3	2.9	-2.6	-0.7
Pavlov. Cond. response bias	2.8	3.4	5.4	2.3	-2.2	-0.4
Pavlov. Cond. lever latency	3.2	4.3	6.7	-1.8	1.6	2.6
Pavlov. Cond. magazine entry latency	1.7	1.9	3.0	1.7	-1.5	-0.6
Pavlov. Cond. change in total contacts	3.0	4.2	6.3	1.7	-1.8	-2.5
Pavlov. Cond. index score	3.0	3.8	4.3	2.0	-1.8	-2.1
Pavlov. Cond. latency score	2.8	3.5	3.8	1.9	-1.7	-1.9
Pavlov. Cond. lever contacts	3.0	4.1	7.7	1.7	-1.3	-2.8
Pavlov. Cond. magazine entry number	1.3	1.5	1.9	-1.3	1.4	1.0
Pavlov. Cond. intertrial magazine entries	3.0	3.9	6.7	-2.1	2.6	0.7
Pavlov. Cond. lever-magazine prob. diff.	2.6	3.3	3.6	1.9	-1.8	-1.8
Pavlov. Cond. response bias	3.3	4.4	6.0	2.0	-1.8	-2.5
Time in closed arm before self-admin	2.5	2.8	3.5	1.9	-1.8	-1.3
Time in closed arm after self-admin	5.4	5.5	6.4	2.5	-2.5	-2.0
Time in open arm before self-admin	0.8	0.9	2.2	-0.3	0.6	-1.5
Time in open arm after self-admin	2.2	2.5	2.9	-1.6	1.7	1.4
Bone: periosteal estimation	0.1	0.2	0.5	0.7	-0.3	0.2
Bone: periosteal perimeter	0.1	0.2	0.4	0.6	-0.2	-0.2
Bone: post-yield work	0.1	0.2	0.3	-0.6	-0.3	-0.2
Progressive ratio test 1 active lever presses	0.4	0.5	0.9	-1.0	0.3	0.6
Progressive ratio test 1 breakpoint	0.3	0.3	0.8	-0.9	0.2	0.3
Progressive ratio test 1 inactive lever presses	1.4	1.6	2.6	-1.6	1.4	-0.4
Progressive ratio test 2 active lever presses	5.0	5.4	6.2	-2.5	2.0	2.4
Progressive ratio test 2 breakpoint	3.3	3.7	4.3	-2.1	1.7	2.0
Progressive ratio test 2 inactive lever presses	2.2	2.5	3.7	-1.9	1.6	1.1
Incentive Sensitization - Responses	5.2	5.3	5.7	-2.2	2.2	2.4
Incentive Sensitization - Breakpoint	4.6	4.7	4.9	-2.1	2.2	2.2
Sum of active levers in priming session hrs 5-6	0.8	0.8	1.3	-1.1	0.8	0.7
Progressive ratio	0.4	0.5	1.3	0.2	0.0	-1.1
Food seeking constrained by brief footshock	2.4	2.9	5.5	-1.6	0.9	2.3
Seeking ratio, punishment vs. effort	0.9	1.1	3.0	-0.7	-0.1	1.7
Retroperitoneal fat weight	0.3	1.1	1.5	-1.2	0.8	1.2
Reaction time number correct	0.1	0.1	0.3	-0.1	0.5	-0.1
Reaction time mean minus median	0.0	0.0	0.1	0.3	-0.1	-0.2
Reaction time mean minus median AUC	0.0	0.0	0.0	0.0	0.0	0.2
Reaction time num false alarms	0.6	0.9	2.2	1.5	-0.6	0.2
Reaction time num false alarms AUC	0.6	0.9	2.0	1.4	-0.8	0.2
Reaction time trials correct on left	0.1	0.1	0.3	-0.1	0.5	-0.1
Reaction time trials on left	0.1	0.1	0.4	-0.2	0.6	0.0
Reaction time mean	0.5	0.7	0.9	-0.8	0.9	1.0
Reaction time mean AUC	0.4	0.6	1.0	-0.5	0.7	1.0
Median of all reaction times	0.8	1.1	1.3	-1.0	1.1	1.1
Reaction time omissions	2.9	3.9	5.0	-1.9	2.2	1.8
Reaction time false alarm rate	0.7	1.0	1.8	1.3	-1.0	0.1
Reaction time premature initiation rate	0.0	0.0	0.1	0.2	-0.3	0.0
Reaction time premature initiations	0.0	0.0	0.1	0.1	0.1	0.3
Std. dev. reaction times	0.3	0.4	0.4	-0.6	0.6	0.6
Reaction time trials completed	0.1	0.1	0.4	-0.2	0.6	0.0
Reaction time trials AUC	0.1	0.2	0.5	-0.2	0.7	-0.1
Run reversals in cocaine runway, females	0.9	0.9	1.5	-0.5	0.9	1.2
Run reversals in cocaine runway, males	1.4	1.4	1.6	1.3	-1.2	-1.1
Latency to leave start box in cocaine runway	0.3	0.3	0.4	-0.3	0.6	-0.6
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.2	0.6	0.3
Latency to leave start box in cocaine runway, M	0.8	0.8	1.8	-0.5	0.6	-1.3
Std. dev. time between licks in bursts	1.3	1.6	2.4	-0.9	1.5	1.3
Total sessions with >9 infusions	1.8	2.0	2.2	-1.5	1.3	1.4
Short access day 1 total inactive lever presses	0.2	0.3	0.4	-0.6	0.6	-0.3
Short access day 10 total inactive lever presses	0.5	0.6	1.3	-1.1	0.7	0.4
Short access day 1 total infusions	1.9	2.0	3.2	-1.8	1.4	1.0
Short access day 10 total infusions	0.0	0.0	0.0	-0.2	-0.1	-0.1
Short access total infusions	0.3	0.3	0.6	-0.7	0.5	0.2
Short access day 1 locomotion	0.0	0.0	0.1	-0.2	0.1	0.3
Short access day 10 total locomotion	0.3	0.3	0.5	0.7	-0.6	-0.0
Short access total locomotion	0.1	0.1	0.2	0.3	-0.2	-0.4
One hour access (0.3 mA shock)	2.6	3.1	5.0	-1.5	1.3	2.2
Compulsive drug intake	0.4	0.4	0.5	0.5	-0.6	-0.7
One hour access (shock baseline)	3.9	4.6	6.5	-2.0	1.8	2.5
Social response proportion	3.0	3.2	3.7	-1.6	1.9	1.8
Social responses	1.8	2.3	3.1	-1.1	1.8	1.6
Social time	0.3	0.4	0.6	0.8	-0.4	-0.7
Soleus weight	0.1	0.2	0.7	0.1	-0.8	-0.1
Bone: stiffness	1.1	1.7	2.8	1.5	-1.7	0.1
Tibialis anterior weight	7.0	23.9	28.5	4.7	-5.3	-4.6
Time to tail flick, vehicle, before self-admin	0.7	0.8	1.5	0.8	-0.4	1.2
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.3	0.4	-0.2	0.5
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.2	0.1	-0.1
Time to tail flick, test, after self-admin	3.0	3.1	4.3	-1.9	2.1	1.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.3	0.4	0.2
Delta time to tail flick, test, before/after SA	2.2	1.9	2.6	-1.6	1.6	0.8
Tibia length	1.6	4.4	8.5	2.9	-1.7	-1.4
Ambulatory time before self-admin	0.2	0.2	0.3	0.6	-0.6	-0.3
Ambulatory time after self-admin	0.3	0.3	0.5	0.5	-0.7	-0.2
Bone: tissue strength	0.9	0.9	1.9	-0.7	1.4	0.6
Total heroin consumption	0.0	0.0	0.0	0.1	-0.0	-0.2
Bone: trabecular number	0.1	0.1	0.3	-0.1	0.5	-0.1
Bone: trabecular spacing	0.1	0.2	0.3	-0.0	-0.6	0.4
Bone: trabecular thickness	2.3	2.7	3.2	1.8	-1.6	-1.5
Bone: trabecular tissue density	0.5	0.7	1.3	0.6	-1.1	-0.6
Water consumed over 24 hours	1.0	1.2	2.0	1.4	-1.1	-0.5
Number of responses in last shaping day	0.2	0.2	0.3	-0.3	0.4	-0.5