LOC108349685

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	LOC108349685	0.18	0.09	5.2e-06	0.06	0.09	0.08	0.09	4.5e-04	2.8e-05	3.4e-05	1.5e-05
2	PL	gene expression	LOC108349685	0.2	0.09	5.8e-14	0.1	0.14	0.14	0.13	6.7e-11	1.1e-14	6.3e-15	3.5e-14
3	Adipose	gene expression	LOC108349685	0.21	0.09	0.0e+00	0.15	0.15	0.16	0.16	3.4e-16	2.0e-16	5.8e-17	7.7e-17
4	Adipose	alternative polyA	XR_005494751.1	0.03	0.02	8.4e-03	0.02	0.02	0.02	0.02	2.9e-03	2.3e-03	3.7e-03	3.4e-03
5	Adipose	alternative polyA	XR_005494745.1	0.03	0.02	8.4e-03	0.02	0.02	0.02	0.02	3.0e-03	2.2e-03	2.6e-03	3.4e-03
6	NAcc	gene expression	LOC108349685	0.13	0.07	5.3e-10	0.07	0.09	0.08	0.08	2.9e-08	2.7e-10	2.1e-09	1.6e-09
7	Adipose	alternative TSS	XR_001836073.2	0.06	0.03	8.7e-06	0.06	0.04	0.05	0.05	9.0e-07	1.2e-05	2.3e-06	1.6e-06
8	Brain	gene expression	LOC108349685	0.2	0.09	1.6e-09	0.12	0.1	0.12	0.12	1.1e-11	5.3e-10	7.0e-11	1.5e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.7	1.2	2.3	-0.9	1.4	-0.9	-0.9	0.9	-1.5	-1.3	0.6
Area under the delay curve	0.5	0.5	1.1	0.5	-0.3	-0.8	-1.0	1.0	-0.0	0.4	-1.0
BMI with tail	1.6	5.1	8.6	-2.6	2.8	-1.7	-2.1	2.2	-2.9	-2.5	0.1
BMI without tail	0.5	1.1	1.9	-1.1	0.9	-0.9	-1.3	1.4	-1.0	-0.9	-0.8
Body weight	0.6	2.7	12.5	-3.5	2.4	1.1	0.8	-0.7	-0.9	0.3	0.2
Weight adjusted by age	1.5	1.7	3.4	-1.9	1.4	1.4	1.4	-1.4	-0.1	1.0	1.1
Bone surface	2.5	4.5	12.2	-3.5	3.3	0.7	1.1	-1.0	-2.1	-0.4	2.3
Bone volume	1.9	3.2	8.2	-2.4	2.9	-0.1	0.3	-0.2	-2.3	-1.0	2.2
Breakpoint value in progressive ratio session	2.1	2.3	4.8	-2.2	1.9	1.5	1.4	-1.4	-0.3	1.2	1.5
Number of licking bursts	0.2	0.3	0.6	-0.7	0.8	0.4	0.4	-0.4	-0.3	0.2	0.5
Context. condit. distance diff. score	1.2	1.5	2.6	1.6	-1.2	-1.4	-1.4	1.4	-0.0	-1.1	-0.7
Locomotion velocity, session 1	0.4	0.4	1.3	0.4	-1.0	0.1	-0.0	0.0	0.9	0.4	-1.1
Locomotion distance, session 1	0.3	0.4	0.9	-0.3	0.0	-0.7	-0.9	1.0	-0.3	-0.1	-0.9
Locomotion velocity, session 2	0.5	0.5	2.5	-1.6	1.1	0.4	0.2	-0.2	-0.3	0.6	-0.2
Locomotion distance, session 2	0.2	0.3	1.1	-0.4	0.0	-0.4	-0.7	0.7	0.1	0.3	-1.1
Locomotion velocity, session 3	1.3	1.5	2.6	0.6	-0.2	-1.6	-1.6	1.6	-0.8	-1.6	-0.6
Locomotion distance, session 3	0.1	0.1	0.1	0.3	-0.3	-0.3	-0.4	0.4	0.0	-0.2	-0.4
Stereotopy head waving bouts, day 3	1.8	2.1	3.6	1.2	-0.7	-1.9	-1.9	1.9	-0.7	-1.8	-0.8
Stereotopy head waving duration, day 3	0.9	1.1	1.9	1.0	-0.4	-1.4	-1.3	1.3	-0.6	-1.4	-0.1
Locomotion velocity, session 7	2.0	2.2	4.3	0.5	0.3	-1.9	-2.0	2.1	-1.4	-1.7	-0.1
Locomotion distance, session 7	0.8	1.0	2.3	0.8	-0.7	-1.1	-1.5	1.5	-0.1	-0.5	-1.1
Stereotopy head waving bouts, day 7	0.7	0.8	1.7	-0.4	1.2	-0.6	-0.3	0.4	-1.3	-1.2	1.1
Stereotopy head waving duration, day 7	1.0	1.2	3.8	-1.6	1.9	0.3	0.3	-0.3	-1.1	-0.4	1.2
Locomotion velocity, session 8	0.5	0.6	1.3	-0.3	-0.6	0.7	0.6	-0.6	1.1	0.7	-1.1
Locomotion distance, session 8	0.8	1.2	2.2	0.5	-0.2	-1.5	-1.4	1.4	-0.9	-1.3	-0.4
Degree of sensitization distance	0.7	0.8	1.5	0.3	-0.3	-1.1	-1.2	1.2	-0.6	-1.0	-0.6
Degree of sensitization stereotypy	1.2	1.3	3.7	-1.5	1.9	0.4	0.5	-0.5	-1.2	-0.5	1.6
Conditioned locomotion	0.4	0.5	1.3	-1.1	0.2	0.9	0.8	-0.8	0.4	0.5	-0.2
Cocaine response after cond. corrected	1.8	2.0	4.0	2.0	-1.8	-1.3	-1.4	1.4	0.5	-0.8	-1.5
Cocaine response after cond. not corrected	1.4	1.5	2.8	1.7	-1.5	-1.3	-1.3	1.2	0.4	-0.8	-1.3
Cocaine response before conditioning	0.8	1.0	2.1	-1.5	1.3	0.7	0.9	-0.8	-0.5	0.5	1.2
Saline control response	1.0	1.3	3.1	-1.8	0.7	1.4	1.1	-1.1	0.7	1.4	-0.3
Bone: connectivity density	0.8	1.3	4.1	-1.9	2.0	0.0	-0.0	0.1	-1.3	-0.5	0.9
Bone: cortical apparent density	0.5	0.6	2.3	-0.4	-0.1	1.0	0.6	-0.6	0.9	1.5	-0.4
Bone: cortical area	0.6	0.9	1.9	-1.4	1.2	0.6	0.9	-0.9	-0.7	-0.2	1.1
Bone: cortical porosity	0.2	0.2	0.4	-0.3	0.6	-0.3	-0.4	0.4	-0.5	-0.5	0.1
Bone: cortical porosity	0.1	0.1	0.6	-0.8	0.7	0.2	0.0	0.0	-0.2	-0.1	0.0
Bone: cortical thickness	1.6	2.7	4.8	-1.5	0.2	2.2	1.9	-1.9	1.6	2.2	-0.3
Bone: cortical thickness	1.3	1.5	3.5	0.2	-1.2	1.1	0.7	-0.8	1.9	1.6	-1.3
Bone: cortical tissue density	0.6	0.8	2.7	-0.4	-0.1	1.1	0.7	-0.7	1.1	1.7	-0.5
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	-0.2	0.1	-0.0	-0.2	0.2	0.1	0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	-0.1	0.0	0.4	0.1	-0.2	0.4	0.6	-0.1
Condit. Reinf. active responses	0.2	0.2	0.4	-0.3	0.3	-0.5	-0.5	0.6	-0.6	-0.3	0.1
Condit. Reinf. inactive responses	0.8	0.9	2.0	-0.1	0.4	-1.2	-0.9	1.0	-1.4	-1.3	0.5
Incentive salience index mean	0.2	0.2	0.4	-0.4	0.3	-0.4	-0.6	0.6	-0.4	-0.2	-0.3
Condit. Reinf. lever presses	0.2	0.3	0.9	-0.9	0.6	-0.4	-0.2	0.3	-1.0	-0.6	0.2
Condit. Reinf. active minus inactive responses	0.5	0.6	1.8	-0.3	0.9	-0.3	-0.1	0.1	-1.1	-0.7	1.3
Condit. Reinf. active-inactive response ratio	1.8	1.9	4.6	-0.3	1.3	-1.1	-0.5	0.6	-2.2	-1.9	1.9
Condit. Reinf. active responses	0.2	0.3	0.8	-0.5	0.9	0.0	-0.1	0.1	-0.7	0.0	0.8
Condit. Reinf. inactive responses	0.3	0.4	1.4	-0.0	-0.2	0.4	-0.2	0.2	0.8	1.2	-0.9
Condit. Reinf. lever presses	1.8	2.5	5.6	-2.4	2.3	1.1	1.3	-1.3	-1.1	0.2	1.8
Condit. Reinf. lever reinforcers received	0.4	0.5	1.4	-0.9	1.2	0.4	0.4	-0.4	-0.6	0.3	1.0
Conditioned reinforcement - actives	0.5	0.5	1.4	-0.6	0.6	0.0	0.7	-0.7	-0.9	0.2	1.2
Conditioned reinforcement - inactives	0.9	1.1	3.1	1.4	-0.2	-1.2	-0.4	0.4	-1.0	-0.7	1.8
Conditioned locomotion	1.1	1.4	5.5	2.3	-1.5	-1.4	-0.7	0.6	-0.4	-0.3	0.3
Patch foraging indifference point 0 sec	0.0	0.0	0.1	0.1	0.0	-0.2	-0.2	0.2	-0.1	-0.1	0.2
Patch foraging indifference point AUC	2.5	2.9	5.7	-2.4	1.9	1.9	1.9	-1.9	-0.1	1.3	1.3
Delay disc. indifference point, 0s delay	1.5	1.7	4.5	1.0	-1.1	-1.4	-1.6	1.6	0.0	0.1	-2.1
Delay disc. indifference point, 16s delay	0.6	0.6	1.0	0.7	0.3	-0.9	-1.0	1.0	-0.7	-0.4	0.5
Delay disc. indifference point, 2s delay	0.3	0.3	0.8	0.2	-0.0	-0.7	-0.6	0.6	-0.5	-0.9	-0.2
Delay disc. indifference point, 24s delay	0.8	0.8	1.7	0.9	-1.1	0.0	-0.2	0.2	1.1	1.1	-1.3
Delay disc. indifference point, 4s delay	1.0	1.1	2.6	1.0	-1.0	-0.9	-1.2	1.2	0.5	0.5	-1.6
Delay disc. indifference point, 8s delay	0.8	0.8	2.3	0.7	-0.9	-0.5	-0.8	0.8	0.6	0.9	-1.5
Indifference point function ln k	6.0	8.3	17.5	4.2	-3.5	-3.0	-3.0	2.9	0.6	-2.1	-2.4
Indifference point function log k	6.0	8.3	17.5	4.2	-3.5	-3.0	-3.0	2.9	0.6	-2.1	-2.4
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	0.3	-0.4	0.1	-0.0	-0.0	0.5	0.3	-0.3
Patch foraging total patch changes 12 sec	1.9	2.4	6.0	-2.5	1.9	1.7	1.5	-1.4	0.0	1.5	0.8
Patch foraging total patch changes 18 sec	0.4	0.6	1.6	-1.1	1.3	0.3	0.4	-0.3	-0.7	0.1	0.8
Patch foraging total patch changes 24 sec	1.6	1.9	2.9	-1.7	0.9	1.7	1.7	-1.7	0.6	1.6	0.5
Patch foraging total patch changes 6 sec	0.1	0.2	0.7	-0.8	0.4	0.4	0.2	-0.2	0.2	0.5	-0.2
Patch foraging time to switch 0 sec	1.3	2.1	6.3	-2.0	2.5	-0.3	-0.3	0.4	-1.9	-0.9	1.1
Patch foraging water rate 0 sec	1.2	2.0	6.9	2.6	-2.6	-0.4	-0.1	0.0	1.2	-0.4	-0.7
Patch foraging water rate 12 sec	4.2	6.5	18.7	4.3	-4.3	-1.2	-1.1	0.9	2.3	-0.6	-2.4
Patch foraging water rate 18 sec	2.4	3.3	8.1	2.8	-2.8	-1.3	-1.3	1.3	1.1	-0.7	-1.9
Patch foraging water rate 24 sec	1.8	2.6	8.0	2.8	-2.7	-1.0	-0.8	0.7	1.1	-0.8	-1.2
Patch foraging water rate 6 sec	3.0	4.3	12.5	3.3	-3.5	-1.0	-0.9	0.9	1.8	-0.5	-2.2
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.7	0.4	-0.1	-0.4	-0.8	0.8	-0.1	-0.2	-0.3
Distance traveled before self-admin	0.9	0.9	2.2	-1.5	1.3	0.6	0.8	-0.8	-0.8	0.1	1.1
Distance traveled after self-admin	0.6	0.7	2.0	-0.9	1.1	0.7	0.7	-0.7	-0.3	0.1	1.4
Extensor digitorum longus weight	1.9	7.6	27.3	-5.2	3.1	2.9	2.4	-2.3	-0.1	2.1	0.5
Bone: elastic displacement	1.8	2.1	6.2	1.9	-2.5	0.1	-0.0	-0.0	1.9	0.5	-1.7
Bone: elastic work	1.0	1.3	3.1	0.2	-1.4	0.9	0.6	-0.6	1.8	1.3	-1.5
Bone: endosteal estimation	2.1	4.5	11.1	0.6	0.6	-2.7	-2.2	2.2	-2.6	-3.3	0.7
Bone: endosteal perimeter	2.5	5.2	12.8	0.2	1.4	-2.6	-1.8	1.8	-3.2	-3.6	1.8
Epididymis fat weight	1.4	3.3	6.2	1.9	-0.7	-2.5	-1.9	1.9	-1.6	-2.5	0.2
Delta time in closed arm before/after self-admin	1.5	1.4	3.7	1.2	-1.6	-0.2	-0.7	0.7	1.4	0.9	-1.9
Delta time in open arm before/after self-admin	1.3	1.2	2.9	-1.2	1.4	0.8	1.2	-1.1	-0.7	0.2	1.7
Diff in mean of infusions in LGA sessions	0.9	1.0	2.6	-0.6	0.6	1.1	1.0	-1.0	0.4	1.6	1.0
Delay discount exponential model param	0.4	0.4	0.9	-0.4	0.3	0.6	0.9	-0.9	-0.1	-0.5	1.0
Extinction: sum of active levers before priming	1.9	1.9	5.4	-2.3	2.2	1.1	0.8	-0.7	-0.5	0.8	1.2
Active lever presses in extinction session 6	3.0	2.9	4.8	-2.2	1.5	1.8	2.1	-2.1	-0.2	1.2	1.5
Bone: final force	1.0	1.7	5.9	-2.4	1.7	0.9	1.0	-1.0	-0.7	0.2	0.9
Bone: final moment	0.9	1.5	5.3	-2.3	1.6	0.9	1.0	-0.9	-0.7	0.2	0.9
Food consumed during 24 hour testing period	0.7	0.8	1.6	-0.7	0.5	1.0	1.3	-1.3	0.1	0.8	1.0
Glucose	2.1	3.1	5.7	1.4	-0.4	-2.4	-2.2	2.2	-1.6	-2.2	0.0
Heart weight	2.2	3.2	6.1	2.5	-1.9	-2.1	-2.1	2.0	-0.1	-1.0	-1.4
Delay discount hyperbolic model param	0.4	0.4	1.0	-0.4	0.3	0.6	0.8	-0.8	-0.1	-0.4	1.0
Intermittent access intake day 1-15 change	0.5	0.5	1.9	0.0	0.2	0.3	0.8	-0.9	-0.3	0.5	1.4
Intermittent access intake escalation	0.3	0.3	1.5	0.1	0.3	0.0	0.5	-0.5	-0.4	0.2	1.2
Intermittent access intake escalation 2	0.7	0.7	1.9	-0.4	0.5	0.8	1.1	-1.1	-0.1	0.7	1.4
Intermitt. access day 1 inactive lever presses	0.5	0.6	1.4	1.2	-0.3	-1.0	-0.8	0.8	-0.6	-0.1	0.7
Intermitt. access day 15 inactive lever presses	0.8	0.8	3.1	0.7	0.4	-1.0	-0.4	0.4	-1.2	-0.4	1.8
Intermitt. access escalation Index	4.2	3.7	5.1	2.2	-1.7	-2.1	-2.3	2.2	-0.1	-2.0	-1.8
Intermittent access day 1 total infusions	5.3	6.1	13.3	1.7	-0.4	-3.6	-3.0	3.0	-2.5	-2.9	-0.1
Intermittent access day 15 total infusions	3.1	3.5	7.9	1.8	-0.4	-2.8	-1.8	1.8	-2.2	-2.0	1.1
Intermittent access terminal intake (last 3 days)	3.2	3.5	7.3	1.1	0.1	-2.7	-1.6	1.6	-2.6	-2.5	1.3
Intermittent access total infusions	3.7	4.1	8.9	1.2	0.1	-3.0	-2.1	2.1	-2.6	-2.5	0.7
Intermittent access day 1 locomotion	5.0	5.2	11.3	1.9	-0.9	-3.4	-3.1	3.1	-1.8	-1.8	-1.0
Intermittent access day 15 total locomotion	1.7	1.9	4.6	1.3	-0.1	-2.2	-1.4	1.4	-1.8	-0.7	1.1
Intermittent access total locomotion	4.9	5.6	12.7	1.4	0.2	-3.6	-2.6	2.7	-3.0	-2.5	0.9
Intermittent access standard deviation	0.2	0.2	0.3	0.5	-0.3	-0.3	0.2	-0.2	-0.4	0.6	0.6
Left kidney weight	0.3	0.7	1.9	0.6	0.1	-1.0	-0.6	0.6	-1.0	-1.4	0.9
Right kidney weight	0.3	0.9	3.3	-0.5	0.9	0.1	0.7	-0.7	-1.1	-0.6	1.8
Cocaine induced anxiety	0.2	0.3	0.6	-0.6	0.6	0.1	0.5	-0.5	-0.6	-0.3	0.8
Post-drug Anxiety	1.7	1.8	3.2	-1.8	1.4	1.2	1.6	-1.6	-0.4	0.7	1.5
Baseline Anxiety	1.4	1.5	4.0	-1.2	0.7	1.4	1.2	-1.2	0.7	2.0	0.5
Tail length	1.1	3.5	6.0	-0.7	-0.9	2.3	2.1	-2.1	2.2	2.5	-1.0
Length with tail	1.2	4.4	8.0	-2.3	0.6	2.8	2.7	-2.7	1.4	2.3	0.1
Length without tail	0.9	1.9	4.1	-2.0	1.1	1.7	1.7	-1.6	0.2	1.1	0.6
Times rat made contact with spout	0.3	0.4	1.5	-0.2	-0.1	0.6	0.1	-0.1	0.8	1.2	-0.6
Lifetime Intake	3.6	4.1	9.1	1.3	-0.2	-3.0	-2.3	2.3	-2.3	-2.3	0.2
Liver weight, left	0.1	0.2	0.7	0.2	-0.0	-0.4	-0.3	0.3	-0.3	-0.9	0.2
Liver weight, right	0.4	0.6	0.9	0.8	-1.0	-0.8	-0.7	0.7	0.2	-1.0	-1.0
Locomotor activity	1.8	2.9	8.1	2.7	-2.9	-0.6	-0.6	0.6	1.6	0.4	-2.0
Locomotor testing distance	3.1	5.1	13.8	3.4	-3.7	-0.8	-0.9	0.8	2.3	0.5	-2.9
Locomotor testing rearing	2.1	3.3	8.3	2.8	-2.9	-0.8	-1.0	0.9	1.7	0.5	-2.2
Locomotion in novel chamber	1.3	1.6	3.2	1.2	-0.4	-1.8	-0.9	0.9	-1.6	-1.7	1.0
Locomotion in novel chamber post-restriction	0.9	1.1	2.3	1.5	-0.8	-1.4	-1.0	1.0	-0.7	-1.3	0.0
Fecal boli incidents, locomotor time 1	1.5	1.6	4.3	-1.4	1.8	0.3	0.7	-0.7	-1.5	-0.6	2.1
Change in fecal boli incidents, locomotor task	1.3	1.3	2.9	1.1	-1.3	-0.8	-1.2	1.2	0.7	0.3	-1.7
Time >=10cm from walls, locomotor time 1	2.7	2.7	7.7	-0.3	1.2	-2.0	-1.4	1.4	-2.8	-1.9	1.0
Bouts of movement, locomotor time 1	2.5	2.7	6.0	-1.5	1.2	2.2	1.7	-1.7	0.8	2.4	0.9
Total resting periods, locomotor time 1	1.8	2.0	3.5	-1.4	1.3	1.8	1.5	-1.4	0.3	1.9	1.1
Rest time, locomotor task time 1	0.2	0.2	0.9	0.9	-0.8	-0.4	-0.1	0.1	-0.0	-0.1	-0.0
Distance moved, locomotor task time 1	0.3	0.4	0.8	-0.2	0.3	-0.7	-0.8	0.8	-0.6	-0.9	-0.4
Vertical activity count, locomotor time 1	0.6	0.6	1.6	1.3	-0.7	-0.9	-0.8	0.8	-0.1	-0.7	-0.1
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.0	-1.0	0.8	0.2	0.4	-0.4	-0.9	0.1	0.5
Bouts of movement, locomotor time 2	0.6	0.7	1.8	-0.7	0.7	1.1	0.7	-0.7	0.5	1.3	0.5
Total resting periods, locomotor time 2	0.4	0.4	1.3	-0.5	0.7	0.8	0.4	-0.4	0.2	1.1	0.5
Rest time, locomotor task time 2	1.1	1.2	2.6	1.5	-1.0	-1.6	-1.3	1.3	-0.6	-0.6	-0.5
Distance moved, locomotor task time 2	0.6	0.7	1.3	-1.1	0.4	1.1	1.0	-1.0	0.5	0.6	-0.2
Vertical activity count, locomotor time 2	0.8	0.9	2.7	0.8	-1.3	0.7	0.7	-0.7	1.6	0.7	-0.7
Light reinforcement 1	0.1	0.3	0.6	0.6	-0.6	0.3	0.2	-0.3	0.8	0.6	-0.5
Light reinforcement 2	0.7	0.9	2.6	-0.0	0.9	-0.4	0.3	-0.3	-1.4	-1.3	1.6
Bone: marrow area	2.1	4.6	11.2	0.7	0.5	-2.8	-2.3	2.3	-2.5	-3.3	0.5
Bone: maximum diameter	0.9	1.7	3.6	-1.5	1.6	0.1	0.8	-0.8	-1.6	-1.1	1.9
Bone: maximum force	1.7	2.9	8.6	-2.9	2.7	0.3	0.4	-0.4	-2.0	-0.6	1.6
Bone: maximum moment	1.4	2.4	7.2	-2.7	2.5	0.2	0.3	-0.3	-1.8	-0.7	1.5
Mean time between licks in bursts	0.9	1.3	3.5	0.4	-1.5	0.5	0.2	-0.2	1.7	1.2	-1.9
Mean num. licks in bursts	0.3	0.4	0.8	0.8	-0.9	-0.2	-0.4	0.4	0.7	0.4	-0.8
Cd content in liver	0.3	0.3	1.5	0.4	0.3	-0.0	0.5	-0.5	-0.5	-0.5	1.2
Co content in liver	2.2	2.6	5.5	2.1	-2.3	0.5	0.0	-0.1	2.3	1.4	-1.8
Cu content in liver	0.1	0.1	0.3	-0.6	0.6	0.3	0.0	-0.0	-0.0	0.6	0.1
Fe content in liver	0.1	0.1	0.3	-0.5	0.4	0.1	0.5	-0.5	-0.4	-0.2	0.3
K content in liver	0.5	0.5	1.2	-1.1	0.9	-0.4	-0.6	0.6	-0.9	-0.6	-0.0
Mg content in liver	1.0	1.0	2.2	-0.2	0.6	-1.2	-1.4	1.5	-1.1	-1.0	-0.2
Mn content in liver	1.8	2.0	5.0	-2.2	1.7	1.2	1.4	-1.4	-0.7	0.5	1.4
Na content in liver	0.8	0.8	2.1	-1.5	0.8	0.9	1.1	-1.1	-0.3	0.0	0.7
Rb content in liver	1.2	1.5	2.9	1.5	-0.8	-1.5	-1.7	1.7	-0.4	-1.0	-0.6
Se content in liver	1.1	1.3	3.1	-1.0	1.6	-0.1	0.4	-0.4	-1.6	-0.9	1.8
Sr content in liver	3.3	3.0	5.2	-1.9	1.0	2.2	2.3	-2.3	0.8	1.7	0.9
Zn content in liver	0.5	0.5	1.3	-1.1	1.1	0.7	0.4	-0.4	-0.1	0.8	0.5
Bone: minimum diameter	2.1	3.9	8.1	0.5	0.8	-2.5	-2.2	2.3	-2.3	-2.8	0.7
Time in familiar zone, hab. session 1	0.5	0.5	0.8	0.4	-0.1	-0.9	-0.9	0.9	-0.6	-0.9	-0.2
Time in novel zone, hab. session 1	0.8	0.8	2.0	0.9	-1.4	0.3	0.2	-0.2	1.3	0.9	-1.0
Total zone transitions, hab. session 1	0.2	0.3	0.9	-1.0	0.7	0.5	0.3	-0.3	-0.1	0.7	0.1
Total locomotion distance, hab. session 1	0.5	0.8	1.5	0.4	0.1	-1.2	-1.2	1.2	-0.9	-0.9	-0.1
Locomotion velocity, hab. session 1	0.3	0.4	0.6	0.0	0.4	-0.8	-0.8	0.8	-0.7	-0.7	0.1
Time in familiar zone, hab. session 2	1.0	1.0	2.8	1.0	-1.7	-0.0	-0.2	0.1	1.3	0.2	-1.6
Time in novel zone, hab. session 2	0.4	0.4	1.2	-0.8	1.1	0.0	-0.1	0.1	-0.7	0.2	0.7
Total zone transitions, hab. session 2	0.5	0.6	1.2	-1.1	1.0	-0.5	-0.9	0.9	-0.8	-0.2	-0.4
Total locomotion distance, hab. session 2	1.1	1.4	3.1	0.3	0.2	-1.5	-1.7	1.8	-1.0	-1.1	-0.7
Locomotion velocity, hab. session 2	1.3	1.7	3.3	0.2	0.4	-1.7	-1.8	1.8	-1.4	-1.5	-0.3
Novel to familiar place preference ratio	1.9	2.0	4.6	-1.9	2.1	0.8	1.0	-0.9	-1.2	0.4	1.9
Novelty place preference	1.3	1.3	3.3	-1.5	1.8	0.6	0.7	-0.7	-1.1	0.3	1.6
Time in novel zone, NPP test	0.9	0.9	2.3	-1.3	1.5	0.5	0.6	-0.6	-0.9	0.2	1.3
Total zone transitions, NPP test	0.5	0.8	3.3	-1.8	1.3	0.6	0.3	-0.3	-0.5	0.7	0.1
Total locomotion distance, NPP test	0.3	0.4	1.0	-0.1	0.3	-0.8	-1.0	1.0	-0.6	-0.4	-0.4
Locomotion velocity, NPP test	0.2	0.3	0.7	-0.3	0.5	-0.6	-0.8	0.8	-0.6	-0.2	-0.1
Intraocular pressure	0.6	0.8	3.1	-0.0	0.4	0.5	1.1	-1.1	-0.5	0.6	1.8
Delta distance traveled before/after self-admin	0.2	0.2	0.6	0.8	-0.5	0.1	-0.1	0.1	0.7	0.2	0.0
Delta ambulatory time before/after self-admin	0.3	0.3	1.1	0.8	-0.7	0.2	-0.1	0.1	1.0	0.5	-0.3
Parametrial fat weight	2.3	4.5	8.0	1.4	-0.1	-2.8	-2.5	2.6	-2.2	-2.8	0.4
Pavlov. Cond. lever latency	0.1	0.2	0.5	0.7	-0.4	0.3	0.2	-0.2	0.6	0.3	-0.0
Pavlov. Cond. magazine entry latency	0.3	0.4	1.0	-0.7	1.0	-0.4	-0.5	0.5	-1.0	-0.3	0.5
Pavlov. Cond. change in total contacts	0.7	0.7	1.7	-0.9	1.3	-0.1	0.0	0.0	-1.3	-0.3	1.3
Pavlov. Cond. index score	0.1	0.2	0.5	-0.7	0.6	0.2	0.2	-0.2	-0.5	0.1	0.5
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.4	0.3	-0.2	-0.2	0.2	-0.5	-0.2	0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.1	-0.2	-0.4	-0.4	0.4	-0.3	-0.3	-0.3
Pavlov. Cond. magazine entry number	0.6	0.7	1.2	1.0	-1.0	-0.8	-0.9	0.8	0.4	-0.5	-1.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.4	-0.2	0.1	0.3	-0.3	-0.0	-0.1	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	-0.9	0.8	0.3	0.3	-0.2	-0.6	0.1	0.6
Pavlov. Cond. response bias	0.2	0.2	0.4	-0.6	0.5	0.4	0.4	-0.4	-0.4	0.2	0.6
Pavlov. Cond. lever latency	0.7	1.0	2.1	1.4	-1.4	-0.3	-0.6	0.6	1.1	0.3	-1.3
Pavlov. Cond. magazine entry latency	1.2	1.4	4.3	-2.1	1.8	1.1	0.9	-0.8	-0.3	0.9	0.6
Pavlov. Cond. change in total contacts	2.8	3.8	9.6	-2.7	3.1	1.1	1.2	-1.2	-1.7	0.1	2.6
Pavlov. Cond. index score	1.8	2.4	5.8	-2.4	2.4	1.0	1.1	-1.0	-1.2	0.2	1.7
Pavlov. Cond. latency score	1.6	2.0	4.9	-2.2	2.2	0.7	0.8	-0.8	-1.3	-0.0	1.6
Pavlov. Cond. lever contacts	0.8	1.1	1.9	-1.4	1.3	0.9	1.2	-1.1	-0.6	0.2	1.2
Pavlov. Cond. magazine entry number	3.1	3.8	9.8	3.1	-2.7	-1.9	-1.7	1.7	0.6	-1.3	-1.4
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.0	1.0	-0.6	-0.9	-0.7	0.7	-0.3	-0.8	0.0
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.5	6.4	-2.5	2.4	1.1	1.2	-1.1	-1.1	0.4	1.6
Pavlov. Cond. response bias	1.5	2.0	4.5	-2.1	2.0	1.2	1.4	-1.3	-0.7	0.5	1.4
Time in closed arm before self-admin	0.5	0.6	1.2	-0.9	1.0	-0.1	0.3	-0.3	-1.1	-0.7	0.9
Time in closed arm after self-admin	0.4	0.4	0.7	0.7	-0.5	-0.7	-0.8	0.8	0.1	-0.1	-0.6
Time in open arm before self-admin	2.8	3.0	6.7	2.1	-2.4	-0.5	-1.2	1.2	1.9	0.7	-2.6
Time in open arm after self-admin	0.4	0.4	1.1	0.5	-0.7	0.6	0.5	-0.5	1.0	0.6	-0.4
Bone: periosteal estimation	1.0	2.0	5.0	-0.7	1.3	-1.2	-0.6	0.6	-2.2	-2.2	1.4
Bone: periosteal perimeter	0.8	1.3	2.7	-1.0	1.4	-0.5	-0.0	0.1	-1.7	-1.4	1.5
Bone: post-yield work	6.0	8.2	19.1	-2.0	3.6	-2.2	-1.9	2.0	-4.4	-3.1	2.6
Progressive ratio test 1 active lever presses	0.9	1.0	1.8	1.2	-0.7	-1.3	-0.9	0.9	-0.8	-1.2	-0.0
Progressive ratio test 1 breakpoint	0.7	0.8	1.5	1.2	-0.8	-1.1	-0.7	0.7	-0.6	-1.2	-0.0
Progressive ratio test 1 inactive lever presses	0.6	0.7	1.5	1.2	-0.8	-0.9	-1.0	0.9	-0.0	-0.4	-0.5
Progressive ratio test 2 active lever presses	1.5	1.6	3.4	1.1	-0.1	-1.8	-1.0	1.0	-1.7	-1.5	1.1
Progressive ratio test 2 breakpoint	1.3	1.4	2.8	1.6	-0.7	-1.7	-0.9	0.9	-1.2	-1.4	0.8
Progressive ratio test 2 inactive lever presses	2.6	3.0	6.7	1.9	-0.4	-2.6	-1.7	1.7	-2.0	-1.6	1.1
Incentive Sensitization - Responses	0.5	0.5	1.6	-0.0	0.7	-0.7	-0.3	0.3	-1.1	-0.6	1.3
Incentive Sensitization - Breakpoint	0.6	0.6	1.7	0.1	0.6	-0.8	-0.3	0.3	-1.1	-0.6	1.3
Sum of active levers in priming session hrs 5-6	5.0	4.8	7.9	-2.4	2.0	2.1	2.7	-2.7	-0.5	1.3	2.8
Progressive ratio	1.1	1.3	3.7	-1.9	1.8	-0.4	-0.5	0.6	-1.6	-0.3	0.1
Food seeking constrained by brief footshock	0.3	0.4	1.1	0.5	-0.7	0.3	-0.0	-0.0	1.0	0.7	-0.8
Seeking ratio, punishment vs. effort	1.9	2.3	6.2	2.5	-2.4	0.1	-0.1	0.1	2.1	0.5	-1.2
Retroperitoneal fat weight	2.9	9.5	19.6	3.6	-1.7	-3.9	-3.3	3.3	-2.0	-4.4	-0.0
Reaction time number correct	0.3	0.4	0.9	-0.5	-0.2	0.8	0.9	-0.9	0.6	0.7	-0.2
Reaction time mean minus median	2.7	3.5	8.8	-3.0	2.7	1.4	1.5	-1.5	-1.2	0.8	1.9
Reaction time mean minus median AUC	1.5	2.0	4.5	-2.1	1.6	1.3	1.5	-1.5	-0.5	0.9	1.2
Reaction time num false alarms	1.4	1.9	4.7	1.4	-2.1	-0.5	-0.9	0.8	1.5	0.4	-2.2
Reaction time num false alarms AUC	1.0	1.4	4.2	0.8	-1.6	-0.0	-0.5	0.5	1.6	0.9	-2.0
Reaction time trials correct on left	0.3	0.4	0.9	-0.5	-0.2	0.8	0.9	-0.9	0.6	0.7	-0.2
Reaction time trials on left	0.4	0.5	1.1	-0.5	-0.2	0.9	1.0	-1.0	0.7	0.8	-0.2
Reaction time mean	0.6	0.8	1.8	-1.1	1.2	0.5	0.7	-0.6	-0.7	0.3	1.3
Reaction time mean AUC	0.6	0.8	2.1	-1.1	1.4	0.4	0.5	-0.5	-0.9	0.3	1.4
Median of all reaction times	0.2	0.3	1.1	-0.5	0.8	0.1	0.2	-0.2	-0.7	0.1	1.1
Reaction time omissions	0.8	1.1	2.4	-1.5	0.9	1.1	0.9	-0.9	0.1	1.5	0.3
Reaction time false alarm rate	1.0	1.4	3.2	1.2	-1.6	-0.7	-1.1	1.0	1.0	0.1	-1.8
Reaction time premature initiation rate	1.4	1.8	4.3	-0.6	-0.7	1.6	1.0	-1.0	2.1	1.3	-1.8
Reaction time premature initiations	2.4	3.4	6.0	-1.2	-0.6	2.4	1.8	-1.8	2.4	2.1	-1.6
Std. dev. reaction times	1.3	1.8	3.6	-1.9	1.8	1.1	1.2	-1.2	-0.8	0.7	1.5
Reaction time trials completed	0.4	0.5	1.1	-0.5	-0.2	0.9	1.0	-1.0	0.7	0.8	-0.2
Reaction time trials AUC	0.2	0.3	0.6	-0.3	-0.4	0.6	0.7	-0.8	0.6	0.5	-0.4
Run reversals in cocaine runway, females	1.6	1.5	3.6	0.5	-0.5	-1.2	-1.8	1.8	-0.0	-0.4	-1.9
Run reversals in cocaine runway, males	0.5	0.5	1.2	0.7	-1.1	0.5	0.7	-0.8	0.9	0.2	-0.4
Latency to leave start box in cocaine runway	0.7	0.8	1.3	-0.0	0.6	-1.0	-1.0	1.0	-1.1	-1.1	0.4
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.3	0.6	-0.3	-0.4	0.5	-0.6	-0.6	0.1
Latency to leave start box in cocaine runway, M	0.4	0.3	0.6	0.1	0.2	-0.8	-0.6	0.6	-0.7	-0.8	0.5
Std. dev. time between licks in bursts	1.3	1.6	4.1	1.3	-2.0	-0.1	-0.3	0.3	1.6	0.5	-2.0
Total sessions with >9 infusions	2.5	2.7	5.4	1.5	-0.8	-2.3	-2.1	2.1	-1.1	-1.6	-0.7
Short access day 1 total inactive lever presses	1.9	2.1	4.3	2.1	-1.0	-2.0	-1.8	1.8	-0.6	-0.8	-0.1
Short access day 10 total inactive lever presses	2.1	2.4	6.8	2.6	-2.0	-1.4	-1.6	1.5	0.7	0.0	-1.2
Short access day 1 total infusions	3.6	3.9	7.5	1.5	-0.5	-2.7	-2.5	2.5	-1.6	-2.3	-0.5
Short access day 10 total infusions	4.1	4.6	9.5	0.9	0.3	-3.1	-2.7	2.7	-2.4	-2.3	-0.0
Short access total infusions	2.7	3.1	6.5	1.1	-0.4	-2.5	-2.3	2.3	-1.6	-1.8	-0.7
Short access day 1 locomotion	3.0	3.2	6.8	1.6	-0.7	-2.6	-2.4	2.4	-1.3	-1.4	-0.5
Short access day 10 total locomotion	2.4	2.7	5.5	1.3	-0.5	-2.4	-2.2	2.2	-1.3	-1.5	-0.6
Short access total locomotion	2.4	2.5	5.2	1.3	-0.6	-2.3	-2.2	2.2	-1.1	-1.1	-0.9
One hour access (0.3 mA shock)	3.0	3.5	7.4	2.5	-1.5	-2.7	-1.7	1.7	-1.5	-2.1	0.1
Compulsive drug intake	2.2	2.2	5.8	-0.3	-0.8	2.1	1.1	-1.1	2.4	1.2	-1.7
One hour access (shock baseline)	2.8	3.2	7.0	1.5	-0.1	-2.6	-1.3	1.3	-2.5	-2.0	1.7
Social response proportion	0.6	0.7	1.5	-1.2	1.1	0.8	0.8	-0.8	-0.3	0.6	0.7
Social responses	0.3	0.4	0.8	-0.4	-0.0	0.8	0.8	-0.8	0.6	0.9	-0.0
Social time	0.4	0.5	0.8	-0.4	-0.3	0.9	0.8	-0.8	0.8	0.9	-0.3
Soleus weight	1.7	4.9	10.6	3.2	-2.2	-2.6	-2.3	2.3	-0.6	-2.5	-0.7
Bone: stiffness	1.8	2.9	7.8	-2.7	2.8	0.4	0.5	-0.4	-1.9	-0.5	1.8
Tibialis anterior weight	4.3	14.6	37.1	-6.1	3.3	4.5	4.4	-4.3	0.6	3.1	1.3
Time to tail flick, vehicle, before self-admin	0.3	0.3	1.1	-1.0	0.8	-0.3	-0.1	0.2	-0.9	-0.1	0.0
Time to tail flick, vehicle, after self-admin	0.3	0.4	1.5	-0.5	0.0	-0.4	-0.6	0.7	-0.0	-0.3	-1.2
Time to tail flick, test, before self-admin	2.6	2.6	4.4	1.2	-1.0	-2.0	-2.1	2.1	-0.7	-1.2	-1.7
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.1	-0.1	0.3	0.4	-0.4	0.2	0.3	-0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.5	-0.0	-0.1	-0.1	-0.4	0.4	0.3	-0.1	-0.7
Delta time to tail flick, test, before/after SA	3.9	3.5	7.0	-1.4	0.6	2.5	2.6	-2.6	1.2	1.7	1.1
Tibia length	1.9	5.5	9.8	-3.0	2.8	1.7	2.5	-2.4	-1.5	0.2	3.1
Ambulatory time before self-admin	1.5	1.6	3.5	-1.6	1.8	0.5	0.9	-0.9	-1.2	-0.2	1.9
Ambulatory time after self-admin	0.9	0.9	3.5	-0.5	1.4	-0.2	-0.1	0.1	-1.1	-0.7	1.9
Bone: tissue strength	0.3	0.2	0.6	-0.5	0.8	0.0	0.2	-0.2	-0.6	-0.2	0.8
Total heroin consumption	2.3	2.7	6.4	-2.5	1.7	2.0	1.6	-1.6	0.3	1.5	0.5
Bone: trabecular number	1.0	1.6	3.8	-1.4	1.9	-0.4	-0.2	0.3	-1.8	-1.1	1.5
Bone: trabecular spacing	0.7	0.9	2.1	1.2	-1.3	-0.1	-0.4	0.4	1.2	0.7	-1.4
Bone: trabecular thickness	0.7	0.8	1.2	0.4	0.3	-1.1	-1.0	1.0	-1.1	-1.1	0.6
Bone: trabecular tissue density	0.7	1.0	3.2	1.8	-1.1	-1.1	-0.8	0.7	-0.2	-1.0	-0.0
Water consumed over 24 hours	1.0	1.2	3.4	-0.7	0.1	1.4	1.1	-1.1	1.1	1.8	-0.2
Number of responses in last shaping day	0.8	0.9	2.3	1.5	-1.5	-0.5	-0.5	0.5	0.7	0.3	-1.1