Hub : Traits : Tibialis anterior weight : ← →

chr12:27,006-4,653,252

Trait: Tibialis anterior weight

Best TWAS P=3.961743e-10 · Best GWAS P=2.407123e-08 conditioned to 1

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	N4bp2l2	alternative polyA	ENSRNOT00000111844	0.14	0.12	top1	1	0.12	7.1e-13	-5.3	5.3	1.2e-07	-0.94	0.08	0.92	FALSE
2	Adipose	N4bp2l2	alternative polyA	ENSRNOT00000118063	0.14	0.12	top1	1	0.12	3.9e-13	-5.3	-5.3	1.2e-07	0.94	0.08	0.92	FALSE
3	Adipose	Pet100	alternative TSS	ENSRNOT00000071928	0.22	0.10	enet	116	0.13	3.4e-14	-5.5	5.6	2.4e-08	-0.98	0.21	0.79	FALSE
4	Adipose	Pet100	alternative TSS	ENSRNOT00000107172	0.22	0.10	enet	122	0.13	2.6e-14	-5.3	-5.6	2.2e-08	0.98	0.21	0.79	FALSE
5	Adipose	Trappc5	gene expression	ENSRNOG00000001003	0.09	0.03	top1	1	0.03	9.9e-05	-5.4	-5.4	7.4e-08	0.58	0.09	0.26	FALSE
6	Adipose	Evi5l	gene expression	ENSRNOG00000001034	0.09	0.00	top1	1	0.00	4.2e-01	-5.4	5.4	5.1e-08	-0.74	0.06	0.04	FALSE
7	Adipose	Mcemp1	gene expression	ENSRNOG00000028259	0.15	0.06	top1	1	0.06	3.2e-07	-5.3	5.3	1.1e-07	-0.74	0.26	0.73	FALSE
8	Adipose	Insr	gene expression	ENSRNOG00000029986	0.13	0.02	top1	1	0.02	4.3e-03	-5.2	5.2	2.5e-07	-0.56	0.05	0.03	FALSE
9	Adipose	N4bp2l1	gene expression	ENSRNOG00000059322	0.32	0.23	lasso	16	0.24	1.2e-26	-5.4	-5.5	4.9e-08	0.96	0.07	0.93	FALSE
10	Adipose	Pet100	isoform ratio	ENSRNOT00000071928	0.23	0.11	enet	64	0.13	1.8e-14	-5.5	5.6	1.8e-08	-0.97	0.18	0.82	FALSE
11	Adipose	Pet100	isoform ratio	ENSRNOT00000107172	0.23	0.09	enet	66	0.13	2.6e-14	-5.5	-5.6	1.8e-08	0.98	0.18	0.82	FALSE
12	Adipose	Zfp958	isoform ratio	ENSRNOT00000102786	0.03	0.00	enet	169	0.01	6.9e-03	-4.7	5.4	5.7e-08	-0.83	0.30	0.30	FALSE
13	Adipose	Zfp958	intron excision ratio	chr12:3971128:3971331	0.03	0.00	blup	1113	0.01	2.8e-02	-4.5	5.6	2.7e-08	-0.77	0.22	0.19	FALSE
14	Adipose	Elavl1	mRNA stability	ENSRNOG00000001069	0.16	0.06	blup	2406	0.07	9.4e-09	-4.8	5.7	1.6e-08	-0.75	0.76	0.24	FALSE
15	Adipose	Cers4	mRNA stability	ENSRNOG00000001072	0.14	0.09	top1	1	0.09	1.7e-10	-5.1	5.1	3.5e-07	-0.25	0.39	0.60	FALSE
16	BLA	Stxbp2	gene expression	ENSRNOG00000000994	0.19	0.13	top1	1	0.13	1.6e-07	-5.3	-5.3	1.2e-07	0.54	0.24	0.64	FALSE
17	BLA	Pet100	intron excision ratio	chr12:1680794:1680963	0.36	0.12	lasso	13	0.19	1.7e-10	-5.4	-5.8	6.6e-09	0.94	0.20	0.80	FALSE
18	BLA	Pet100	intron excision ratio	chr12:1680995:1681508	0.35	0.12	lasso	11	0.20	9.8e-11	-5.4	5.8	7.3e-09	-0.91	0.20	0.80	FALSE
19	BLA	Cers4	mRNA stability	ENSRNOG00000001072	0.16	0.06	blup	2109	0.08	5.0e-05	-4.8	5.4	5.9e-08	-0.66	0.67	0.30	FALSE
20	BLA	Stard13	mRNA stability	ENSRNOG00000001090	0.08	0.05	blup	1438	0.05	1.3e-03	-5.3	5.2	1.5e-07	-0.77	0.32	0.55	FALSE
21	Brain	Pcp2	gene expression	ENSRNOG00000000993	0.12	0.10	top1	1	0.10	1.8e-09	-5.4	5.4	7.0e-08	-0.44	0.18	0.82	FALSE
22	Brain	Elavl1	gene expression	ENSRNOG00000001069	0.07	0.01	blup	2406	0.02	4.4e-03	-4.8	-5.7	1.5e-08	0.76	0.52	0.33	FALSE
23	Brain	Arhgef18	gene expression	ENSRNOG00000028090	0.12	0.06	enet	11	0.08	1.2e-07	-4.9	-5.8	5.6e-09	0.93	0.30	0.70	FALSE
24	Brain	N4bp2l1	gene expression	ENSRNOG00000059322	0.06	0.05	lasso	2	0.05	3.5e-05	-5.4	-5.4	8.4e-08	0.99	0.09	0.90	FALSE
25	Brain	Trappc5	intron excision ratio	chr12:1737769:1740114	0.05	0.02	enet	18	0.03	5.1e-04	-5.2	-6.3	4.0e-10	0.81	0.28	0.63	TRUE
26	Brain	Insr	mRNA stability	ENSRNOG00000029986	0.72	0.55	enet	150	0.60	8.8e-69	-5.5	5.2	2.1e-07	-0.97	0.15	0.85	FALSE
27	Eye	Elavl1	intron excision ratio	chr12:2667464:2684652	0.69	0.25	lasso	30	0.31	1.3e-05	-5.1	5.9	3.6e-09	-0.92	0.45	0.25	FALSE
28	IL	Snapc2	gene expression	ENSRNOG00000001056	0.35	0.00	lasso	5	0.03	8.2e-02	-5.2	-5.9	4.9e-09	0.60	0.25	0.36	FALSE
29	IL	Cers4	gene expression	ENSRNOG00000001072	0.30	0.08	top1	1	0.08	7.0e-03	-5.1	5.1	3.0e-07	-0.22	0.12	0.07	FALSE
30	IL	Insr	intron excision ratio	chr12:1257822:1307450	0.73	0.50	top1	1	0.50	6.5e-14	-5.5	5.5	4.4e-08	-0.94	0.12	0.87	FALSE
31	IL	N4bp2l2	mRNA stability	ENSRNOG00000001108	0.16	0.06	lasso	1	0.08	4.7e-03	-5.2	5.2	1.9e-07	-0.73	0.12	0.50	FALSE
32	LHb	Arhgef18	gene expression	ENSRNOG00000028090	0.31	0.09	top1	1	0.10	3.0e-03	-5.4	-5.4	7.5e-08	0.69	0.08	0.09	FALSE
33	Liver	N4bp2l2	alternative polyA	ENSRNOT00000111844	0.10	0.04	blup	681	0.07	2.3e-08	-4.9	5.4	7.6e-08	-0.94	0.42	0.58	FALSE
34	Liver	N4bp2l2	alternative polyA	ENSRNOT00000118063	0.10	0.04	blup	681	0.07	1.5e-08	-4.9	-5.4	6.4e-08	0.94	0.42	0.58	FALSE
35	Liver	Mcoln1	gene expression	ENSRNOG00000000975	0.09	0.04	lasso	39	0.04	1.7e-05	-5.5	5.4	5.5e-08	-1.00	0.16	0.83	FALSE
36	Liver	Timm44	gene expression	ENSRNOG00000001058	0.11	0.03	enet	10	0.04	7.4e-05	-5.0	5.7	1.1e-08	-0.61	0.33	0.65	FALSE
37	Liver	Stxbp2	isoform ratio	ENSRNOT00000107607	0.15	0.09	lasso	10	0.09	5.9e-10	-5.0	-5.7	1.4e-08	0.89	0.24	0.76	FALSE
38	Liver	Stxbp2	isoform ratio	ENSRNOT00000115749	0.10	0.05	top1	1	0.05	6.9e-06	-5.2	5.2	2.1e-07	-0.60	0.30	0.46	FALSE
39	Liver	N4bp2l1	isoform ratio	ENSRNOT00000110394	0.06	0.03	blup	587	0.04	6.9e-05	-4.9	5.4	8.6e-08	-0.86	0.40	0.59	FALSE
40	Liver	Pet100	intron excision ratio	chr12:1680794:1680963	0.21	0.04	blup	1823	0.09	1.9e-10	-5.2	-5.8	7.3e-09	0.87	0.26	0.74	FALSE
41	Liver	Pet100	intron excision ratio	chr12:1680995:1681508	0.18	0.05	enet	152	0.07	3.1e-08	-4.9	5.7	9.7e-09	-0.55	0.40	0.60	FALSE
42	Liver	Zfp958	intron excision ratio	chr12:3953566:3958666	0.03	0.00	blup	1113	0.01	1.1e-02	-4.3	-5.6	2.2e-08	0.74	0.23	0.34	FALSE
43	Liver	N4bp2l2	mRNA stability	ENSRNOG00000001108	0.03	0.02	top1	1	0.02	2.0e-03	-5.4	5.4	8.5e-08	-0.97	0.03	0.16	FALSE
44	NAcc	Pet100	alternative TSS	ENSRNOT00000071928	0.08	0.03	top1	1	0.03	1.4e-03	-5.3	5.3	1.0e-07	-0.92	0.09	0.14	FALSE
45	NAcc	Stxbp2	gene expression	ENSRNOG00000000994	0.10	0.07	top1	1	0.07	9.6e-06	-5.3	-5.3	1.0e-07	0.93	0.13	0.31	FALSE
46	NAcc	Cers4	gene expression	ENSRNOG00000001072	0.27	0.25	enet	26	0.27	5.9e-20	-5.0	5.8	8.5e-09	-0.52	0.41	0.59	FALSE
47	NAcc	Arhgef18	gene expression	ENSRNOG00000028090	0.13	0.05	blup	1531	0.08	1.3e-06	-4.5	-5.6	2.4e-08	0.84	0.51	0.49	FALSE
48	NAcc	Lrrc8e	gene expression	ENSRNOG00000028460	0.31	0.06	lasso	12	0.07	1.2e-05	-5.1	-5.6	2.2e-08	0.82	0.24	0.65	TRUE
49	NAcc	Trappc5	isoform ratio	ENSRNOT00000001327	0.11	0.04	lasso	38	0.04	2.9e-04	-5.4	-5.7	1.3e-08	0.98	0.19	0.81	FALSE
50	NAcc	Trappc5	isoform ratio	ENSRNOT00000111016	0.09	0.02	lasso	29	0.03	5.1e-03	-5.4	5.7	1.5e-08	-0.98	0.19	0.78	FALSE
51	NAcc	Snapc2	mRNA stability	ENSRNOG00000001056	0.13	0.07	top1	1	0.06	1.3e-05	-5.4	-5.4	5.8e-08	0.76	0.07	0.76	FALSE
52	NAcc	Brca2	mRNA stability	ENSRNOG00000001111	0.14	0.09	lasso	42	0.09	4.2e-07	-5.3	5.4	8.2e-08	-1.00	0.10	0.90	FALSE
53	NAcc	Insr	mRNA stability	ENSRNOG00000029986	0.37	0.23	lasso	29	0.23	1.8e-17	-5.4	5.2	1.9e-07	-0.99	0.16	0.84	FALSE
54	OFC	Stxbp2	gene expression	ENSRNOG00000000994	0.43	0.14	top1	1	0.14	2.8e-04	-5.4	-5.4	6.3e-08	0.81	0.10	0.08	FALSE
55	OFC	Snapc2	gene expression	ENSRNOG00000001056	0.54	0.04	blup	2272	0.12	1.0e-03	-5.1	-6.0	2.6e-09	0.80	0.27	0.49	TRUE
56	OFC	Insr	intron excision ratio	chr12:1257822:1307450	0.64	0.28	top1	1	0.28	2.2e-07	-5.5	5.5	4.4e-08	-0.93	0.12	0.70	FALSE
57	OFC	Insr	mRNA stability	ENSRNOG00000029986	0.82	0.37	top1	1	0.37	1.0e-09	-5.3	5.3	1.0e-07	-0.96	0.23	0.69	TRUE
58	PL	Stxbp2	gene expression	ENSRNOG00000000994	0.13	0.05	blup	1819	0.06	2.6e-05	-5.2	-5.8	6.0e-09	0.83	0.29	0.71	FALSE
59	PL	Snapc2	gene expression	ENSRNOG00000001056	0.47	0.25	enet	50	0.28	8.7e-22	-5.2	-5.1	2.8e-07	0.31	0.28	0.72	FALSE
60	PL	Arhgef18	isoform ratio	ENSRNOT00000066281	0.07	0.05	top1	1	0.05	8.6e-05	-5.3	5.3	1.2e-07	-0.56	0.08	0.12	TRUE
61	PL	Arhgef18	isoform ratio	ENSRNOT00000110862	0.08	0.06	top1	1	0.06	2.4e-05	-5.3	-5.3	1.2e-07	0.51	0.12	0.26	FALSE
62	PL	Snapc2	intron excision ratio	chr12:2606007:2606962	0.06	0.04	top1	1	0.04	2.5e-04	-5.2	5.2	2.1e-07	0.02	0.13	0.34	FALSE
63	PL	Snapc2	intron excision ratio	chr12:2606335:2606962	0.18	0.16	top1	1	0.16	6.0e-12	-5.2	-5.2	1.9e-07	0.03	0.19	0.81	FALSE
64	PL	Pet100	intron excision ratio	chr12:1680794:1680963	0.49	0.13	blup	1822	0.18	2.5e-13	-4.9	-5.5	3.4e-08	0.87	0.56	0.44	FALSE
65	PL	Pet100	intron excision ratio	chr12:1680995:1681508	0.38	0.13	lasso	17	0.16	1.8e-12	-4.9	5.3	1.4e-07	0.60	0.60	0.40	TRUE
66	PL	Insr	mRNA stability	ENSRNOG00000029986	0.65	0.46	lasso	32	0.49	2.3e-42	-5.4	5.2	1.7e-07	-0.98	0.16	0.84	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.