Men1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Men1	0.18	0.07	0.0e+00	0.15	0.14	0.14	0.15	2.8e-16	3.0e-15	1.5e-15	2.1e-16
2	pVTA	mRNA stability	Men1	0.05	0.04	4.1e-04	0.04	0.04	0.02	0.03	4.6e-04	5.1e-04	4.6e-03	1.3e-03
3	PL	mRNA stability	Men1	0.04	0.03	1.4e-05	0.05	0.04	0.05	0.04	4.1e-06	2.5e-05	4.9e-06	2.7e-05
4	Adipose	mRNA stability	Men1	0.07	0.04	7.1e-07	0.05	0.04	0.04	0.04	3.6e-06	5.4e-05	1.3e-05	8.7e-06
5	NAcc	mRNA stability	Men1	0.01	0.01	3.3e-03	0.01	0.01	0	0.01	2.4e-03	3.4e-03	5.4e-02	7.3e-03
6	NAcc	intron excision ratio	chr1_213055138_213056652	0.05	0.03	1.3e-09	0.07	0.06	0.04	0.06	2.7e-10	1.7e-09	6.2e-07	4.6e-09
7	Adipose	intron excision ratio	chr1_213068402_213068668	0.03	0.02	8.1e-03	0.01	0.01	0.01	0.01	4.5e-02	1.4e-02	2.4e-02	4.8e-02
8	Liver	gene expression	Men1	0.03	0.02	8.0e-03	0.02	0	-0	0.01	1.3e-03	1.0e-01	3.9e-01	1.3e-02
9	Brain	gene expression	Men1	0.09	0.05	4.1e-05	0.06	0.06	0.06	0.06	1.3e-06	3.2e-06	3.0e-06	1.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.4	0.7	1.7	-0.9	-0.9	-0.9	-0.7	-0.9	-0.7	1.3	0.8	-0.4
Area under the delay curve	0.1	0.1	0.5	0.0	0.0	-0.2	0.1	-0.1	-0.3	0.6	0.5	0.7
BMI with tail	1.6	5.6	13.4	-2.4	-2.4	-2.4	-2.4	-2.3	-2.2	3.7	1.9	-0.3
BMI without tail	0.8	2.5	6.7	-1.5	-1.5	-1.7	-1.5	-1.5	-1.7	2.6	0.6	0.9
Body weight	2.5	11.1	18.4	-3.8	-3.7	-3.7	-3.7	-3.7	-3.5	4.3	0.0	-0.0
Weight adjusted by age	1.2	1.9	2.5	-1.5	-1.5	-1.5	-1.6	-1.4	-1.4	1.0	-1.3	-0.8
Bone surface	3.8	6.9	9.4	-3.0	-3.1	-3.0	-3.0	-3.0	-2.2	2.7	-0.3	-2.1
Bone volume	1.4	2.5	3.9	-1.7	-1.8	-1.7	-1.7	-1.7	-1.0	1.5	0.4	-2.0
Breakpoint value in progressive ratio session	2.8	3.3	4.7	-2.1	-2.0	-2.2	-2.0	-2.0	-2.0	1.6	-1.3	-1.0
Number of licking bursts	0.2	0.3	0.5	-0.6	-0.6	-0.6	-0.7	-0.6	-0.4	0.3	-0.6	-0.5
Context. condit. distance diff. score	1.6	1.9	3.0	1.5	1.6	1.4	1.7	1.6	1.0	-0.9	1.4	0.9
Locomotion velocity, session 1	0.2	0.2	1.1	-0.1	-0.1	-0.0	-0.0	-0.1	-0.4	0.5	0.2	1.0
Locomotion distance, session 1	0.5	0.6	2.0	-0.6	-0.8	-0.5	-0.6	-0.7	-0.7	1.4	0.5	0.7
Locomotion velocity, session 2	2.3	2.6	4.0	-1.8	-1.9	-1.7	-1.8	-1.8	-1.7	2.0	-0.6	0.0
Locomotion distance, session 2	0.6	0.8	2.2	-0.9	-1.0	-0.6	-0.9	-0.9	-1.0	1.5	-0.3	0.8
Locomotion velocity, session 3	0.7	0.8	4.0	0.6	0.4	0.8	0.5	0.6	0.5	0.5	2.0	0.7
Locomotion distance, session 3	0.1	0.1	0.3	0.2	0.2	0.1	0.2	0.3	-0.0	0.1	0.5	0.3
Stereotopy head waving bouts, day 3	1.2	1.4	5.8	1.0	0.9	1.2	0.8	1.0	0.7	0.3	2.4	1.1
Stereotopy head waving duration, day 3	0.8	0.9	2.3	1.0	0.9	1.2	0.9	1.0	0.9	-0.3	1.5	0.3
Locomotion velocity, session 7	0.6	0.6	2.2	0.8	0.6	0.9	0.7	0.7	0.8	0.1	1.5	0.2
Locomotion distance, session 7	0.2	0.3	1.4	0.3	0.2	0.4	0.1	0.3	-0.2	0.7	0.7	1.2
Stereotopy head waving bouts, day 7	0.2	0.2	1.3	0.0	0.1	0.0	0.0	0.1	0.5	-0.2	0.5	-1.1
Stereotopy head waving duration, day 7	0.7	0.8	1.6	-1.0	-1.0	-1.0	-1.0	-1.0	-0.5	0.6	-0.3	-1.3
Locomotion velocity, session 8	1.0	1.2	2.2	-1.1	-1.0	-1.1	-1.0	-1.0	-1.5	1.3	-0.3	1.1
Locomotion distance, session 8	0.3	0.4	1.8	0.6	0.5	0.5	0.7	0.6	0.3	0.3	1.3	0.4
Degree of sensitization distance	0.2	0.2	0.8	0.2	-0.0	0.3	0.0	0.1	0.0	0.7	0.9	0.6
Degree of sensitization stereotypy	0.6	0.6	2.3	-0.8	-0.7	-0.8	-0.8	-0.7	-0.1	0.2	-0.3	-1.5
Conditioned locomotion	1.3	1.5	2.5	-1.3	-1.4	-1.3	-1.6	-1.3	-1.3	1.4	-0.6	0.1
Cocaine response after cond. corrected	1.5	1.7	2.4	1.5	1.4	1.6	1.3	1.5	0.9	-0.5	1.4	1.5
Cocaine response after cond. not corrected	1.1	1.2	1.8	1.2	1.2	1.2	1.2	1.2	0.7	-0.3	1.3	1.2
Cocaine response before conditioning	0.8	0.9	1.4	-1.1	-1.0	-1.2	-0.9	-1.2	-0.6	0.4	-0.9	-1.1
Saline control response	4.0	5.3	7.2	-2.5	-2.5	-2.5	-2.6	-2.6	-2.7	2.5	-1.4	0.5
Bone: connectivity density	2.0	3.2	4.8	-2.0	-2.0	-2.1	-1.9	-2.0	-1.8	2.2	-0.1	-0.7
Bone: cortical apparent density	0.1	0.2	1.3	-0.3	-0.3	-0.3	-0.3	-0.2	-0.3	-0.2	-1.1	0.1
Bone: cortical area	0.6	0.9	1.4	-1.1	-1.1	-1.1	-1.1	-1.2	-0.7	0.7	-0.3	-0.9
Bone: cortical porosity	0.1	0.1	0.2	-0.4	-0.5	-0.3	-0.5	-0.4	-0.3	0.4	-0.3	-0.1
Bone: cortical porosity	0.5	0.6	0.8	-0.8	-0.9	-0.8	-0.9	-0.8	-0.8	0.9	-0.4	-0.0
Bone: cortical thickness	2.7	4.4	5.8	-2.3	-2.3	-2.3	-2.2	-2.3	-2.4	1.6	-2.2	0.5
Bone: cortical thickness	0.7	0.8	2.3	-0.7	-0.7	-0.7	-0.7	-0.7	-1.2	0.9	-0.6	1.5
Bone: cortical tissue density	0.2	0.3	1.7	-0.4	-0.5	-0.5	-0.5	-0.4	-0.5	-0.1	-1.3	0.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.4	-0.4	-0.4	-0.3	-0.3	-0.5	0.5	-0.2	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	-0.2	-0.1	-0.3	-0.1	-0.1	-0.3	-0.0	-0.6	0.1
Condit. Reinf. active responses	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.0	0.0	0.0	0.3	0.3	-0.1
Condit. Reinf. inactive responses	0.3	0.3	1.3	0.4	0.3	0.4	0.4	0.4	0.7	0.0	1.1	-0.4
Incentive salience index mean	0.2	0.3	0.8	-0.6	-0.5	-0.6	-0.5	-0.5	-0.6	0.9	0.2	0.2
Condit. Reinf. lever presses	0.3	0.4	0.8	-0.7	-0.7	-0.7	-0.7	-0.7	-0.4	0.9	0.5	-0.6
Condit. Reinf. active minus inactive responses	0.2	0.3	1.2	0.3	0.2	0.3	0.3	0.3	0.7	-0.6	0.3	-1.1
Condit. Reinf. active-inactive response ratio	1.1	1.3	2.4	0.9	0.8	0.9	0.9	0.9	1.5	-1.0	1.3	-1.6
Condit. Reinf. active responses	0.1	0.2	0.7	-0.3	-0.4	-0.3	-0.3	-0.3	0.0	0.0	-0.3	-0.8
Condit. Reinf. inactive responses	0.6	0.8	1.3	-0.9	-0.8	-1.0	-0.8	-0.9	-1.1	0.9	-1.0	0.6
Condit. Reinf. lever presses	1.5	2.1	3.0	-1.6	-1.7	-1.6	-1.7	-1.6	-0.9	1.0	-0.7	-1.7
Condit. Reinf. lever reinforcers received	0.3	0.4	0.9	-0.7	-0.7	-0.7	-0.7	-0.7	-0.2	0.2	-0.7	-1.0
Conditioned reinforcement - actives	0.5	0.9	6.6	-0.1	-0.0	0.0	-0.1	-0.1	0.7	-0.9	-0.1	-2.6
Conditioned reinforcement - inactives	3.0	4.3	7.2	2.0	2.1	2.0	2.1	2.0	2.5	-2.7	1.0	-2.1
Conditioned locomotion	7.6	9.9	14.5	3.4	3.3	3.5	3.3	3.3	3.8	-3.8	1.7	-1.1
Patch foraging indifference point 0 sec	0.0	0.0	0.1	0.0	0.3	0.1	0.2	-0.0	0.3	-0.2	-0.0	0.0
Patch foraging indifference point AUC	2.1	3.1	4.7	-2.1	-2.0	-2.2	-1.8	-1.9	-1.6	0.9	-1.6	-1.5
Delay disc. indifference point, 0s delay	0.4	0.5	2.5	0.3	0.4	0.2	0.4	0.3	-0.3	0.7	1.6	0.9
Delay disc. indifference point, 16s delay	0.6	0.7	1.0	0.9	1.0	0.7	0.9	1.0	1.0	-0.8	0.6	-0.2
Delay disc. indifference point, 2s delay	0.1	0.1	0.6	0.2	0.3	0.1	0.3	0.1	0.1	0.1	0.8	-0.1
Delay disc. indifference point, 24s delay	0.1	0.1	1.1	0.1	0.1	-0.0	0.2	0.1	-0.2	0.1	-0.2	1.1
Delay disc. indifference point, 4s delay	0.4	0.4	1.7	0.1	0.2	-0.1	0.2	0.1	-0.7	0.8	0.7	1.3
Delay disc. indifference point, 8s delay	0.2	0.2	1.2	0.1	-0.0	-0.1	0.0	-0.1	-0.4	0.7	0.3	1.1
Indifference point function ln k	5.8	10.2	14.1	3.7	3.8	3.6	3.5	3.6	2.8	-2.1	2.8	2.4
Indifference point function log k	5.8	10.2	14.1	3.7	3.8	3.6	3.5	3.6	2.8	-2.1	2.8	2.4
Patch foraging total patch changes 0 sec	0.0	0.0	0.2	-0.1	0.1	-0.0	0.1	-0.1	-0.0	-0.1	-0.3	0.5
Patch foraging total patch changes 12 sec	4.3	5.6	8.0	-2.8	-2.6	-2.8	-2.6	-2.7	-2.4	2.0	-1.9	-0.6
Patch foraging total patch changes 18 sec	0.6	0.9	1.9	-1.2	-1.0	-1.4	-0.9	-1.0	-1.0	0.7	-0.5	-0.8
Patch foraging total patch changes 24 sec	1.5	2.6	3.9	-2.0	-1.8	-1.9	-1.6	-1.9	-1.7	1.2	-1.6	-0.3
Patch foraging total patch changes 6 sec	0.9	1.4	2.1	-1.3	-1.2	-1.2	-1.1	-1.3	-1.4	1.4	-0.6	0.5
Patch foraging time to switch 0 sec	1.0	2.1	3.1	-1.5	-1.7	-1.5	-1.7	-1.7	-1.1	1.8	0.2	-1.2
Patch foraging water rate 0 sec	2.7	5.6	7.8	2.7	2.7	2.7	2.7	2.8	2.3	-2.8	0.6	0.9
Patch foraging water rate 12 sec	5.3	11.1	16.5	3.8	3.7	4.1	3.8	3.8	3.0	-3.3	1.3	2.4
Patch foraging water rate 18 sec	2.6	3.9	6.1	2.3	2.2	2.5	2.1	2.2	1.6	-1.4	1.4	1.9
Patch foraging water rate 24 sec	3.6	5.0	7.0	2.6	2.5	2.7	2.4	2.6	2.0	-2.1	1.3	1.4
Patch foraging water rate 6 sec	3.9	5.6	7.8	2.8	2.6	2.8	2.6	2.8	1.8	-1.9	1.2	2.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.4	0.5	0.5	0.6	0.1	0.5	0.5	-0.1	0.1	0.3
Distance traveled before self-admin	0.6	0.8	2.3	-1.0	-0.9	-1.1	-0.9	-1.0	-0.4	0.6	-0.4	-1.5
Distance traveled after self-admin	0.3	0.4	1.8	-0.5	-0.5	-0.5	-0.5	-0.6	-0.3	-0.0	-1.3	-0.7
Extensor digitorum longus weight	6.7	26.4	35.0	-5.9	-5.9	-5.7	-5.9	-5.8	-5.6	5.5	-2.4	-0.4
Bone: elastic displacement	0.8	1.0	2.8	1.0	1.0	1.0	1.0	1.0	0.3	-0.8	-0.0	1.7
Bone: elastic work	1.1	1.4	2.7	-1.0	-1.0	-1.0	-1.0	-1.1	-1.6	1.3	-0.6	1.6
Bone: endosteal estimation	1.0	2.1	9.2	1.2	1.3	1.3	1.3	1.1	1.4	-0.2	3.0	-0.5
Bone: endosteal perimeter	1.4	3.0	9.8	1.4	1.5	1.5	1.4	1.4	2.0	-0.8	3.1	-1.5
Epididymis fat weight	3.1	10.5	14.1	3.4	3.3	3.2	3.4	3.5	3.8	-3.2	3.3	-1.4
Delta time in closed arm before/after self-admin	1.0	0.9	5.0	-0.3	-0.3	-0.3	-0.3	-0.4	-1.0	1.2	0.3	2.2
Delta time in open arm before/after self-admin	0.8	0.8	4.2	-0.7	-0.4	-0.7	-0.4	-0.5	-0.0	-0.4	-1.1	-2.1
Diff in mean of infusions in LGA sessions	0.5	0.6	1.1	-0.8	-0.8	-1.0	-0.8	-0.8	-1.1	0.7	-0.5	0.1
Delay discount exponential model param	0.1	0.1	0.4	0.1	0.1	0.3	0.0	0.2	0.4	-0.6	-0.3	-0.6
Extinction: sum of active levers before priming	2.1	2.3	3.2	-1.8	-1.6	-1.8	-1.6	-1.7	-1.6	1.7	-0.8	-0.6
Active lever presses in extinction session 6	3.3	3.2	4.6	-2.1	-2.0	-2.1	-2.0	-2.0	-1.5	1.3	-1.3	-1.7
Bone: final force	2.0	3.2	4.5	-2.1	-2.1	-2.0	-2.1	-2.1	-1.7	1.9	-0.4	-0.8
Bone: final moment	1.9	3.0	4.2	-2.0	-2.0	-2.0	-2.0	-2.0	-1.7	1.9	-0.3	-0.7
Food consumed during 24 hour testing period	0.2	0.3	0.9	-0.2	-0.3	-0.2	-0.3	-0.2	0.2	-0.7	-1.0	-0.9
Glucose	2.3	3.6	6.8	2.1	2.0	2.0	2.0	2.1	1.9	-0.8	2.6	0.6
Heart weight	1.3	2.0	7.8	1.2	1.2	1.0	1.3	1.2	0.2	0.7	2.8	1.8
Delay discount hyperbolic model param	0.1	0.1	0.4	0.1	0.0	0.3	0.0	0.2	0.4	-0.6	-0.4	-0.5
Intermittent access intake day 1-15 change	1.0	2.0	4.0	1.3	1.3	1.2	1.4	1.4	1.7	-2.0	0.4	-1.6
Intermittent access intake escalation	0.9	1.8	3.8	1.1	1.2	1.0	1.2	1.2	1.6	-2.0	0.3	-1.8
Intermittent access intake escalation 2	1.5	1.7	3.5	1.1	1.1	1.0	1.1	1.1	1.5	-1.9	0.2	-1.8
Intermitt. access day 1 inactive lever presses	0.1	0.2	0.5	0.4	0.4	0.4	0.4	0.4	0.5	-0.7	-0.2	-0.5
Intermitt. access day 15 inactive lever presses	1.5	3.0	4.5	1.8	1.7	1.7	1.6	1.6	2.1	-1.9	1.4	-1.6
Intermitt. access escalation Index	2.1	3.0	4.3	2.0	2.1	2.0	2.0	2.0	1.7	-1.5	1.0	0.9
Intermittent access day 1 total infusions	2.6	4.2	12.1	2.0	1.9	2.0	1.8	1.9	2.3	-1.2	3.5	-1.0
Intermittent access day 15 total infusions	5.4	8.1	11.7	2.8	2.8	2.8	2.8	2.8	3.4	-3.0	3.0	-2.1
Intermittent access terminal intake (last 3 days)	5.4	7.1	11.2	2.5	2.5	2.5	2.5	2.5	3.2	-2.5	3.3	-2.3
Intermittent access total infusions	4.7	5.5	11.9	2.2	2.2	2.3	2.2	2.2	2.7	-1.9	3.4	-1.6
Intermittent access day 1 locomotion	2.3	2.9	6.9	1.7	1.6	1.6	1.6	1.7	1.9	-1.1	2.6	-0.7
Intermittent access day 15 total locomotion	3.7	6.8	9.8	2.4	2.5	2.4	2.5	2.5	3.1	-2.8	2.6	-2.5
Intermittent access total locomotion	7.9	9.4	13.5	2.9	2.9	2.9	2.9	2.9	3.7	-2.9	3.7	-2.6
Intermittent access standard deviation	1.0	2.0	2.9	1.5	1.4	1.4	1.4	1.4	1.7	-1.7	0.9	-0.9
Left kidney weight	0.5	2.2	3.9	1.4	1.6	1.4	1.8	1.4	1.6	-1.1	2.0	-0.7
Right kidney weight	0.3	1.2	1.9	1.1	1.1	1.1	1.2	1.0	1.4	-1.1	1.3	-0.5
Cocaine induced anxiety	0.1	0.2	1.2	-0.2	-0.1	-0.2	-0.1	-0.2	0.0	-0.2	-0.3	-1.1
Post-drug Anxiety	0.6	0.6	0.8	-0.8	-0.9	-0.8	-0.9	-0.9	-0.7	0.6	-0.5	-0.9
Baseline Anxiety	0.5	0.6	1.2	-0.6	-0.7	-0.5	-0.7	-0.6	-0.9	0.9	-0.5	1.1
Tail length	0.6	2.2	3.9	-1.5	-1.4	-1.6	-1.3	-1.5	-1.7	1.1	-2.0	1.0
Length with tail	1.8	7.8	10.2	-3.1	-3.0	-3.1	-3.1	-3.1	-3.2	2.8	-2.0	0.8
Length without tail	1.8	5.9	8.1	-2.7	-2.7	-2.6	-2.7	-2.7	-2.8	2.6	-1.4	1.1
Times rat made contact with spout	0.6	0.7	1.2	-0.8	-0.7	-0.8	-0.8	-0.8	-1.1	0.8	-1.0	0.6
Lifetime Intake	3.3	4.0	9.8	1.9	1.8	2.0	1.8	1.9	2.3	-1.4	3.1	-1.0
Liver weight, left	0.7	1.2	2.0	1.1	1.2	1.2	1.2	1.2	0.7	-0.5	1.4	0.9
Liver weight, right	1.9	3.3	4.8	2.0	2.1	1.8	2.0	2.0	0.9	-0.7	2.2	1.9
Locomotor activity	1.8	2.8	4.1	1.9	1.9	2.0	1.8	1.9	1.2	-1.3	0.9	1.9
Locomotor testing distance	2.0	3.6	5.9	2.1	2.1	2.2	2.1	2.1	1.2	-1.3	1.2	2.4
Locomotor testing rearing	1.5	3.1	4.5	2.0	2.0	1.9	2.0	1.9	1.1	-1.2	1.1	2.1
Locomotion in novel chamber	5.1	6.6	9.6	2.7	2.7	2.8	2.6	2.8	3.1	-2.6	2.1	-0.7
Locomotion in novel chamber post-restriction	2.5	4.1	5.9	2.2	2.2	2.1	2.3	2.1	2.4	-2.3	1.3	-0.8
Fecal boli incidents, locomotor time 1	0.4	0.5	4.2	-0.3	-0.1	-0.4	-0.0	-0.2	0.2	-0.5	-0.2	-2.0
Change in fecal boli incidents, locomotor task	0.6	0.6	2.9	0.4	0.1	0.4	0.0	0.2	-0.2	0.7	1.2	1.7
Time >=10cm from walls, locomotor time 1	1.2	1.3	3.5	0.7	0.7	0.7	0.8	0.8	1.5	-0.6	1.9	-1.7
Bouts of movement, locomotor time 1	2.0	2.3	9.3	-1.2	-1.4	-1.2	-1.6	-1.4	-1.0	0.1	-3.1	-1.0
Total resting periods, locomotor time 1	1.5	1.7	7.6	-1.0	-1.1	-0.9	-1.3	-1.1	-0.6	-0.1	-2.8	-1.2
Rest time, locomotor task time 1	1.2	1.5	2.6	1.3	1.3	1.3	1.1	1.3	1.5	-1.6	0.3	-0.5
Distance moved, locomotor task time 1	0.1	0.2	0.8	-0.4	-0.3	-0.3	-0.2	-0.3	-0.4	0.9	0.5	0.3
Vertical activity count, locomotor time 1	0.5	1.1	1.7	1.1	1.1	1.2	1.3	1.1	1.0	-0.7	1.1	0.5
Time >=10cm from walls, locomotor time 2	0.3	0.4	2.4	-0.2	-0.4	-0.4	-0.3	-0.2	0.3	-0.4	-0.7	-1.6
Bouts of movement, locomotor time 2	0.3	0.5	1.1	-0.7	-0.7	-0.7	-0.8	-0.7	-0.6	0.3	-1.0	-0.4
Total resting periods, locomotor time 2	0.1	0.2	0.3	-0.4	-0.4	-0.4	-0.5	-0.4	-0.3	0.1	-0.6	-0.4
Rest time, locomotor task time 2	2.2	2.8	4.5	1.7	1.7	2.0	1.6	1.8	1.9	-1.4	2.1	0.0
Distance moved, locomotor task time 2	1.2	1.5	3.0	-1.3	-1.3	-1.2	-1.3	-1.2	-1.2	0.9	-1.7	-0.0
Vertical activity count, locomotor time 2	0.2	0.2	1.3	0.1	0.1	0.2	0.1	0.2	-0.3	-0.1	-0.8	1.2
Light reinforcement 1	0.0	0.1	0.3	0.2	0.3	0.2	0.4	0.0	0.3	-0.5	-0.6	0.2
Light reinforcement 2	1.0	1.6	3.4	1.0	1.0	1.1	1.0	0.8	1.8	-1.7	0.4	-1.8
Bone: marrow area	1.1	2.3	9.6	1.3	1.3	1.4	1.4	1.2	1.5	-0.2	3.1	-0.4
Bone: maximum diameter	0.3	0.5	2.9	-0.6	-0.5	-0.5	-0.5	-0.6	0.1	0.1	0.5	-1.7
Bone: maximum force	2.5	4.5	6.1	-2.4	-2.5	-2.4	-2.5	-2.4	-1.7	2.4	0.2	-1.5
Bone: maximum moment	2.4	4.1	5.6	-2.3	-2.4	-2.3	-2.3	-2.3	-1.7	2.3	0.3	-1.3
Mean time between licks in bursts	0.4	0.9	3.2	-0.5	-0.5	-0.5	-0.6	-0.5	-1.3	1.1	-0.4	1.8
Mean num. licks in bursts	0.1	0.2	0.7	0.5	0.5	0.4	0.5	0.5	0.0	-0.2	0.1	0.8
Cd content in liver	1.4	1.6	2.6	1.1	1.2	0.9	1.2	1.1	1.5	-1.6	0.7	-1.5
Co content in liver	1.1	1.3	2.7	1.2	1.2	1.0	1.2	1.2	0.4	-1.2	-0.5	1.6
Cu content in liver	0.0	0.0	0.1	0.1	0.2	-0.0	0.2	0.1	0.1	-0.2	-0.3	-0.1
Fe content in liver	0.1	0.2	0.3	-0.4	-0.4	-0.5	-0.4	-0.5	-0.5	0.5	0.1	0.3
K content in liver	0.7	0.7	1.8	-0.8	-0.6	-0.8	-0.6	-0.6	-1.1	1.4	0.5	0.6
Mg content in liver	0.4	0.4	1.0	0.6	0.7	0.4	0.7	0.6	0.1	0.2	0.9	1.0
Mn content in liver	2.6	2.9	4.3	-1.9	-2.1	-2.0	-2.1	-2.0	-1.5	1.3	-1.0	-1.2
Na content in liver	0.4	0.4	0.6	-0.7	-0.7	-0.7	-0.7	-0.8	-0.7	0.5	-0.4	-0.2
Rb content in liver	1.9	2.2	3.2	1.7	1.6	1.6	1.6	1.8	1.2	-0.9	1.4	1.4
Se content in liver	0.3	0.4	1.2	0.4	0.4	0.3	0.4	0.3	0.9	-0.8	-0.1	-1.1
Sr content in liver	2.7	2.4	3.2	-1.8	-1.7	-1.8	-1.7	-1.8	-1.4	0.9	-1.7	-0.8
Zn content in liver	0.5	0.5	0.9	-0.8	-0.5	-0.9	-0.5	-0.8	-0.9	0.6	-1.0	0.3
Bone: minimum diameter	0.9	1.7	6.1	1.1	1.2	1.2	1.2	1.0	1.4	-0.3	2.5	-0.5
Time in familiar zone, hab. session 1	0.3	0.3	0.9	0.5	0.5	0.5	0.6	0.5	0.4	-0.2	0.9	0.1
Time in novel zone, hab. session 1	0.2	0.2	1.2	0.4	0.4	0.4	0.3	0.4	0.1	-0.1	-0.0	1.1
Total zone transitions, hab. session 1	0.4	0.6	1.0	-0.9	-1.0	-0.7	-0.9	-0.9	-0.7	0.8	-0.7	-0.2
Total locomotion distance, hab. session 1	0.3	0.4	0.9	0.7	0.5	0.9	0.6	0.7	0.8	-0.2	1.0	0.0
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.2	0.1	0.3	0.1	0.2	0.3	0.1	0.3	-0.1
Time in familiar zone, hab. session 2	0.4	0.4	2.6	-0.0	0.3	-0.1	0.1	-0.1	-0.8	0.5	0.0	1.6
Time in novel zone, hab. session 2	0.1	0.1	0.7	-0.2	-0.4	-0.1	-0.3	-0.1	0.2	-0.0	-0.0	-0.8
Total zone transitions, hab. session 2	1.1	1.4	3.5	-1.3	-1.4	-1.1	-1.3	-1.2	-1.1	1.9	0.1	0.2
Total locomotion distance, hab. session 2	0.2	0.3	1.4	0.1	-0.0	0.2	0.1	0.1	0.0	0.9	1.2	0.6
Locomotion velocity, hab. session 2	0.2	0.3	1.9	0.3	0.2	0.4	0.2	0.3	0.4	0.6	1.4	0.2
Novel to familiar place preference ratio	1.2	1.3	3.8	-1.2	-1.2	-1.2	-1.1	-1.1	-0.5	0.4	-0.7	-2.0
Novelty place preference	0.7	0.7	3.0	-0.8	-0.8	-0.8	-0.7	-0.7	-0.2	0.1	-0.5	-1.7
Time in novel zone, NPP test	0.5	0.5	2.1	-0.7	-0.7	-0.7	-0.6	-0.6	-0.2	0.1	-0.4	-1.4
Total zone transitions, NPP test	1.9	2.7	3.9	-1.9	-2.0	-1.7	-1.9	-1.9	-1.6	1.9	-0.8	-0.3
Total locomotion distance, NPP test	0.1	0.1	0.5	-0.1	-0.3	0.1	-0.2	-0.1	-0.1	0.7	0.6	0.4
Locomotion velocity, NPP test	0.1	0.1	0.4	-0.2	-0.4	0.0	-0.3	-0.2	-0.1	0.6	0.2	0.1
Intraocular pressure	1.3	1.8	4.9	1.1	1.1	1.0	1.2	1.2	1.4	-2.2	-0.5	-1.7
Delta distance traveled before/after self-admin	0.4	0.4	2.2	0.5	0.4	0.7	0.4	0.4	-0.1	-0.3	-0.6	1.5
Delta ambulatory time before/after self-admin	0.3	0.3	2.2	0.2	0.2	0.5	0.2	0.2	-0.2	-0.0	-0.7	1.5
Parametrial fat weight	3.0	7.1	8.9	2.9	3.0	2.7	3.0	2.9	3.0	-2.3	2.8	-0.7
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.6	0.6	0.6	0.6	0.5	0.5	-0.8	-0.1	0.1
Pavlov. Cond. magazine entry latency	0.3	0.4	0.5	-0.7	-0.6	-0.7	-0.7	-0.6	-0.3	0.7	0.2	-0.7
Pavlov. Cond. change in total contacts	0.3	0.3	2.2	-0.4	-0.3	-0.4	-0.4	-0.3	0.3	-0.1	-0.2	-1.5
Pavlov. Cond. index score	0.3	0.3	0.5	-0.7	-0.5	-0.7	-0.7	-0.6	-0.3	0.3	-0.4	-0.7
Pavlov. Cond. latency score	0.1	0.2	0.3	-0.5	-0.4	-0.5	-0.5	-0.4	-0.3	0.5	-0.1	-0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.4	-0.3	-0.4	-0.4	-0.3	-0.4	0.7	0.3	0.1
Pavlov. Cond. magazine entry number	0.4	0.5	1.2	0.8	0.6	0.8	0.8	0.7	0.2	-0.1	0.9	1.1
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.9	0.9	1.0	0.7	0.9	0.9	1.0	-1.4	-0.6	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.8	-0.9	-0.7	-0.9	-0.9	-0.8	-0.5	0.5	-0.4	-0.8
Pavlov. Cond. response bias	0.2	0.3	0.7	-0.6	-0.5	-0.6	-0.7	-0.5	-0.2	0.2	-0.5	-0.8
Pavlov. Cond. lever latency	0.5	0.7	1.8	0.9	1.0	0.9	1.0	0.9	0.4	-0.4	0.4	1.3
Pavlov. Cond. magazine entry latency	4.1	4.9	7.0	-2.6	-2.4	-2.6	-2.4	-2.7	-2.2	2.0	-1.6	-1.0
Pavlov. Cond. change in total contacts	1.5	2.3	5.8	-1.6	-1.6	-1.5	-1.6	-1.7	-0.6	0.6	-1.2	-2.4
Pavlov. Cond. index score	2.2	3.0	4.0	-2.0	-2.0	-1.9	-2.0	-2.0	-1.2	1.3	-1.1	-1.7
Pavlov. Cond. latency score	1.8	2.4	3.3	-1.8	-1.8	-1.7	-1.8	-1.8	-1.0	1.1	-0.9	-1.7
Pavlov. Cond. lever contacts	0.6	0.8	1.8	-0.9	-1.0	-0.9	-1.0	-0.9	-0.4	0.4	-0.5	-1.3
Pavlov. Cond. magazine entry number	6.3	7.8	10.5	3.2	3.2	3.2	3.2	3.2	2.5	-2.2	2.2	1.7
Pavlov. Cond. intertrial magazine entries	0.8	1.3	1.8	1.3	1.3	1.1	1.4	1.3	1.2	-1.1	0.8	0.0
Pavlov. Cond. lever-magazine prob. diff.	2.7	3.6	4.9	-2.2	-2.2	-2.1	-2.1	-2.2	-1.4	1.4	-1.3	-1.8
Pavlov. Cond. response bias	1.9	2.6	3.5	-1.8	-1.9	-1.8	-1.9	-1.9	-1.2	1.2	-1.0	-1.5
Time in closed arm before self-admin	0.4	0.5	1.8	0.5	0.5	0.5	0.5	0.6	0.9	-0.8	0.5	-1.4
Time in closed arm after self-admin	0.4	0.5	0.8	0.8	0.6	0.8	0.6	0.7	0.4	-0.2	0.9	0.9
Time in open arm before self-admin	1.2	1.3	9.7	0.4	0.4	0.4	0.4	0.4	-0.5	0.6	0.5	3.1
Time in open arm after self-admin	0.2	0.3	0.8	-0.5	-0.3	-0.4	-0.3	-0.3	-0.6	0.4	-0.9	0.6
Bone: periosteal estimation	0.3	0.5	3.2	0.0	0.1	0.1	0.1	-0.1	0.5	0.3	1.8	-1.1
Bone: periosteal perimeter	0.2	0.4	1.2	-0.4	-0.4	-0.3	-0.4	-0.4	0.1	0.5	1.1	-1.1
Bone: post-yield work	1.1	1.6	5.6	-0.6	-0.8	-0.5	-0.8	-0.6	0.4	1.2	2.2	-2.4
Progressive ratio test 1 active lever presses	0.5	0.6	1.0	0.6	0.6	0.7	0.6	0.6	1.0	-0.8	1.0	-1.0
Progressive ratio test 1 breakpoint	0.5	0.6	1.2	0.5	0.5	0.7	0.5	0.5	1.0	-0.7	0.9	-1.1
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.9	0.3	0.3	0.3	0.3	0.3	0.6	-0.7	-0.1	-1.0
Progressive ratio test 2 active lever presses	3.2	3.7	5.5	1.8	1.8	1.8	1.8	1.8	2.4	-2.1	1.8	-2.0
Progressive ratio test 2 breakpoint	3.2	3.7	5.5	1.8	1.7	1.8	1.8	1.8	2.4	-2.1	1.8	-2.0
Progressive ratio test 2 inactive lever presses	6.6	10.7	15.5	3.4	3.3	3.4	3.3	3.3	3.9	-3.7	2.5	-2.2
Incentive Sensitization - Responses	0.2	0.3	1.4	0.1	0.1	0.1	0.1	0.2	0.4	-0.2	0.9	-1.2
Incentive Sensitization - Breakpoint	0.3	0.4	1.3	0.3	0.3	0.3	0.4	0.4	0.7	-0.4	1.0	-1.2
Sum of active levers in priming session hrs 5-6	2.0	1.9	7.3	-1.1	-1.0	-1.0	-1.0	-1.1	-0.2	-0.7	-1.9	-2.7
Progressive ratio	0.9	1.4	2.6	-1.3	-1.2	-1.1	-1.4	-1.3	-0.8	1.6	0.4	-0.9
Food seeking constrained by brief footshock	0.1	0.1	0.6	-0.1	-0.2	-0.3	-0.2	-0.2	-0.5	0.5	-0.1	0.8
Seeking ratio, punishment vs. effort	1.3	1.8	3.9	1.5	1.4	1.3	1.6	1.5	0.5	-1.2	0.2	2.0
Retroperitoneal fat weight	8.3	35.4	45.4	6.7	6.7	6.5	6.7	6.7	6.1	-5.2	5.4	1.2
Reaction time number correct	0.2	0.3	0.7	-0.6	-0.8	-0.7	-0.7	-0.4	-0.6	0.3	-0.4	0.1
Reaction time mean minus median	1.6	4.0	5.9	-2.3	-2.2	-2.3	-2.4	-2.2	-1.5	1.5	-1.0	-2.1
Reaction time mean minus median AUC	0.8	2.0	3.1	-1.6	-1.6	-1.6	-1.8	-1.5	-1.1	1.0	-0.9	-1.4
Reaction time num false alarms	0.7	0.9	5.3	0.9	0.8	0.6	0.7	0.9	0.0	0.0	0.3	2.3
Reaction time num false alarms AUC	0.4	0.6	4.6	0.2	0.1	-0.0	0.1	0.2	-0.5	0.6	-0.1	2.2
Reaction time trials correct on left	0.2	0.3	0.7	-0.6	-0.8	-0.7	-0.7	-0.4	-0.6	0.3	-0.4	0.1
Reaction time trials on left	0.2	0.4	0.9	-0.7	-0.9	-0.8	-0.8	-0.5	-0.6	0.4	-0.5	0.1
Reaction time mean	0.2	0.3	2.0	-0.1	-0.2	-0.1	-0.3	-0.0	0.4	-0.3	-0.2	-1.4
Reaction time mean AUC	0.2	0.3	2.2	-0.1	-0.1	-0.1	-0.2	0.0	0.5	-0.4	-0.1	-1.5
Median of all reaction times	0.3	0.4	1.1	0.5	0.4	0.5	0.3	0.6	0.9	-0.7	0.2	-1.1
Reaction time omissions	1.2	1.7	3.4	-1.4	-1.7	-1.3	-1.9	-1.3	-0.9	1.0	-1.0	-0.9
Reaction time false alarm rate	0.5	0.7	3.8	0.7	0.8	0.6	0.7	0.7	0.0	0.2	0.5	1.9
Reaction time premature initiation rate	2.9	4.0	6.8	-2.0	-1.9	-1.9	-2.0	-1.9	-2.6	2.3	-1.1	1.8
Reaction time premature initiations	3.2	5.7	8.8	-2.5	-2.6	-2.4	-2.6	-2.3	-3.0	2.4	-1.8	1.6
Std. dev. reaction times	0.6	1.2	2.7	-1.1	-1.3	-1.1	-1.4	-1.0	-0.6	0.5	-0.7	-1.6
Reaction time trials completed	0.2	0.4	0.9	-0.7	-0.9	-0.8	-0.8	-0.5	-0.6	0.4	-0.5	0.1
Reaction time trials AUC	0.1	0.2	0.5	-0.5	-0.7	-0.5	-0.6	-0.3	-0.5	0.3	-0.2	0.3
Run reversals in cocaine runway, females	1.0	1.0	3.6	-0.4	-0.6	-0.4	-0.5	-0.6	-0.8	1.7	0.8	1.9
Run reversals in cocaine runway, males	0.3	0.3	0.5	0.6	0.6	0.6	0.7	0.6	0.5	-0.7	0.2	0.3
Latency to leave start box in cocaine runway	0.1	0.2	0.9	0.2	0.4	0.3	0.3	0.2	0.3	0.1	0.9	-0.3
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.1	0.1	0.0	0.1	-0.0	0.0	0.1	0.1	-0.3
Latency to leave start box in cocaine runway, M	0.2	0.2	1.2	0.2	0.1	0.1	0.0	0.1	0.1	0.4	1.1	0.0
Std. dev. time between licks in bursts	0.4	0.5	3.8	0.3	0.2	0.3	0.1	0.2	-0.7	0.5	0.3	1.9
Total sessions with >9 infusions	0.2	0.3	1.8	0.2	0.0	0.2	0.0	0.1	0.4	0.3	1.3	-0.4
Short access day 1 total inactive lever presses	2.4	3.2	4.6	2.1	1.8	2.1	1.8	2.0	1.9	-1.4	1.9	0.5
Short access day 10 total inactive lever presses	0.3	0.6	0.9	0.9	0.9	0.8	0.9	0.9	0.5	-0.5	0.3	1.0
Short access day 1 total infusions	1.7	2.2	5.0	1.6	1.5	1.6	1.4	1.5	1.7	-0.8	2.2	-0.1
Short access day 10 total infusions	1.1	1.4	7.2	0.8	0.7	0.9	0.7	0.8	1.1	-0.1	2.7	-0.9
Short access total infusions	1.0	1.2	6.5	0.9	0.7	1.0	0.7	0.8	1.0	0.0	2.5	-0.2
Short access day 1 locomotion	1.6	2.0	3.1	1.5	1.5	1.4	1.5	1.5	1.5	-1.1	1.8	-0.3
Short access day 10 total locomotion	0.8	1.4	2.3	1.2	1.1	1.0	1.2	1.2	1.4	-1.0	1.5	-0.9
Short access total locomotion	1.7	2.0	3.7	1.4	1.4	1.4	1.4	1.4	1.7	-1.1	1.9	-0.8
One hour access (0.3 mA shock)	6.6	7.6	9.5	2.9	3.0	2.9	3.0	3.0	3.1	-2.8	2.6	-0.6
Compulsive drug intake	3.0	3.6	7.7	-1.6	-1.5	-1.7	-1.5	-1.5	-2.3	1.8	-2.1	2.8
One hour access (shock baseline)	6.7	10.3	14.7	3.3	3.2	3.3	3.2	3.2	3.8	-3.4	2.9	-2.3
Social response proportion	0.6	0.7	1.0	-1.0	-0.9	-0.9	-1.0	-0.8	-0.6	0.5	-0.6	-0.8
Social responses	0.3	0.3	0.7	-0.7	-0.5	-0.7	-0.6	-0.6	-0.6	0.4	-0.8	0.0
Social time	0.3	0.4	0.8	-0.7	-0.9	-0.7	-0.8	-0.4	-0.6	0.5	-0.5	0.3
Soleus weight	3.6	10.7	14.7	3.7	3.7	3.8	3.8	3.7	3.4	-3.0	2.2	0.6
Bone: stiffness	1.9	3.1	4.5	-2.0	-2.1	-1.9	-2.1	-2.0	-1.1	1.7	-0.3	-1.7
Tibialis anterior weight	9.0	30.6	41.5	-6.4	-6.4	-6.2	-6.4	-6.3	-5.7	5.0	-3.8	-1.2
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	-0.5	-0.5	-0.6	-0.5	-0.5	-0.5	0.7	0.7	-0.5
Time to tail flick, vehicle, after self-admin	1.0	1.3	3.9	-1.0	-0.8	-1.2	-0.8	-0.8	-1.5	2.0	0.8	0.7
Time to tail flick, test, before self-admin	2.0	2.1	4.6	1.5	1.5	1.5	1.5	1.5	1.4	-0.4	2.1	1.0
Time to tail flick, test, after self-admin	0.1	0.1	0.8	-0.3	-0.3	-0.4	-0.3	-0.2	-0.0	-0.0	-0.3	-0.9
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.6	-0.7	-0.6	-0.8	-0.6	-0.6	-1.0	1.3	0.1	0.8
Delta time to tail flick, test, before/after SA	2.4	2.5	7.8	-1.5	-1.5	-1.6	-1.5	-1.5	-1.1	-0.1	-2.8	-1.6
Tibia length	1.1	3.0	9.0	-1.8	-1.8	-1.8	-1.7	-1.8	-0.6	0.3	-1.4	-3.0
Ambulatory time before self-admin	0.5	0.7	3.6	-0.8	-0.7	-1.0	-0.7	-0.7	-0.1	0.2	-0.2	-1.9
Ambulatory time after self-admin	0.3	0.4	0.8	0.4	0.4	0.4	0.4	0.4	0.8	-0.8	-0.5	-0.9
Bone: tissue strength	0.0	0.0	0.2	0.1	-0.0	0.1	-0.0	0.1	0.3	-0.2	-0.1	-0.4
Total heroin consumption	4.9	5.8	7.3	-2.7	-2.7	-2.6	-2.7	-2.7	-2.4	2.0	-2.4	-0.8
Bone: trabecular number	0.6	1.0	1.7	-1.1	-1.1	-1.2	-1.0	-1.1	-0.6	1.1	0.3	-1.3
Bone: trabecular spacing	0.4	0.6	1.9	0.8	0.7	0.8	0.7	0.9	0.2	-0.4	0.0	1.4
Bone: trabecular thickness	0.4	0.5	0.8	0.7	0.6	0.8	0.7	0.7	0.8	-0.4	0.9	-0.2
Bone: trabecular tissue density	3.5	5.2	7.2	2.5	2.7	2.5	2.6	2.5	2.4	-2.6	1.0	-0.2
Water consumed over 24 hours	1.1	1.5	2.9	-1.3	-1.3	-1.3	-1.3	-1.3	-1.3	0.8	-1.7	0.2
Number of responses in last shaping day	0.1	0.1	0.4	0.1	0.1	0.1	0.0	0.1	-0.1	-0.0	-0.4	0.6