Cst6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	Cst6	0.22	0.11	1.1e-10	0.2	0.2	0.21	0.21	3.9e-11	5.1e-11	2.0e-11	2.1e-11
2	BLA	mRNA stability	Cst6	0.06	0.04	6.6e-03	0.01	0.02	0	0.01	6.9e-02	2.7e-02	2.9e-01	8.9e-02
3	Brain	gene expression	Cst6	0.03	0.03	9.3e-03	0.02	0.02	0.03	0.02	6.8e-03	8.7e-03	1.5e-03	2.6e-03
4	Adipose	gene expression	Cst6	0.37	0.12	0.0e+00	0.19	0.21	0.21	0.21	1.6e-20	2.9e-23	5.2e-23	2.2e-23

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4
Bone: apparent density	1.2	2.0	5.3	-0.9	-0.5	1.3	2.3
Area under the delay curve	0.8	0.8	1.8	-0.0	-0.8	0.9	1.3
BMI with tail	2.9	9.5	14.0	-3.4	0.4	3.5	3.7
BMI without tail	1.5	3.2	4.7	-1.9	0.2	2.1	2.2
Body weight	1.7	7.1	18.3	-4.3	3.0	-0.1	1.2
Weight adjusted by age	1.4	1.6	2.9	-1.5	1.7	-0.9	-0.6
Bone surface	1.7	3.0	7.3	-2.7	1.3	0.1	1.7
Bone volume	0.9	1.5	2.9	-1.5	0.2	0.9	1.7
Breakpoint value in progressive ratio session	1.6	1.8	3.5	-1.9	1.8	-0.6	-0.3
Number of licking bursts	0.1	0.1	0.3	-0.6	0.4	0.0	-0.1
Context. condit. distance diff. score	1.3	1.6	2.4	1.5	-1.6	1.2	0.4
Locomotion velocity, session 1	0.1	0.1	0.2	-0.2	0.4	-0.2	-0.5
Locomotion distance, session 1	0.9	1.2	2.6	-1.1	-0.0	1.0	1.6
Locomotion velocity, session 2	1.4	1.6	4.3	-2.1	1.3	0.2	0.6
Locomotion distance, session 2	0.7	1.0	2.0	-1.3	0.4	0.5	1.4
Locomotion velocity, session 3	0.8	0.9	2.2	0.1	-0.7	1.5	0.9
Locomotion distance, session 3	0.0	0.0	0.0	0.1	-0.2	0.1	0.1
Stereotopy head waving bouts, day 3	1.2	1.4	2.4	0.6	-1.2	1.6	1.1
Stereotopy head waving duration, day 3	1.1	1.3	2.0	0.9	-1.3	1.4	0.8
Locomotion velocity, session 7	2.2	2.4	4.6	0.4	-1.4	2.2	1.7
Locomotion distance, session 7	0.4	0.5	1.3	-0.1	-0.5	0.8	1.1
Stereotopy head waving bouts, day 7	0.5	0.6	1.0	0.5	-0.9	1.0	0.6
Stereotopy head waving duration, day 7	0.5	0.6	1.1	-1.0	0.2	0.6	0.9
Locomotion velocity, session 8	1.1	1.3	1.8	-1.3	1.3	-1.2	-0.4
Locomotion distance, session 8	0.7	1.0	2.5	0.4	-0.9	1.6	0.9
Degree of sensitization distance	0.5	0.5	1.2	-0.1	-0.5	0.6	1.1
Degree of sensitization stereotypy	0.1	0.1	0.3	-0.6	0.2	0.3	0.3
Conditioned locomotion	1.2	1.4	2.6	-1.4	1.6	-1.0	-0.3
Cocaine response after cond. corrected	0.6	0.6	1.2	1.1	-1.0	0.4	0.2
Cocaine response after cond. not corrected	0.4	0.5	0.9	0.9	-1.0	0.4	0.2
Cocaine response before conditioning	0.3	0.3	0.7	-0.9	0.7	-0.2	-0.2
Saline control response	2.3	3.0	6.7	-2.6	2.1	-1.0	0.3
Bone: connectivity density	1.6	2.5	5.3	-2.1	0.5	0.6	2.3
Bone: cortical apparent density	0.2	0.2	0.4	-0.6	0.6	-0.3	-0.3
Bone: cortical area	0.4	0.7	1.3	-0.8	1.2	-0.4	-0.7
Bone: cortical porosity	0.6	0.7	1.4	-0.4	-0.3	1.0	1.2
Bone: cortical porosity	0.5	0.6	1.0	-0.9	0.3	0.6	1.0
Bone: cortical thickness	3.2	5.2	8.2	-2.1	2.9	-2.3	-1.7
Bone: cortical thickness	1.8	2.1	3.6	-0.9	1.5	-1.9	-1.2
Bone: cortical tissue density	0.3	0.3	0.5	-0.7	0.7	-0.4	-0.3
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	-0.5	0.1	0.7	0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.2	0.0	0.3	0.3
Condit. Reinf. active responses	0.2	0.3	0.8	-0.2	-0.0	0.9	0.5
Condit. Reinf. inactive responses	0.3	0.3	0.9	0.2	-0.4	0.9	0.5
Incentive salience index mean	0.5	0.6	1.2	-0.7	0.1	1.1	0.9
Condit. Reinf. lever presses	0.2	0.2	0.4	-0.5	0.4	0.7	0.1
Condit. Reinf. active minus inactive responses	0.3	0.4	0.6	0.5	-0.8	0.7	0.4
Condit. Reinf. active-inactive response ratio	1.1	1.1	1.8	1.1	-1.2	1.4	0.2
Condit. Reinf. active responses	0.3	0.4	1.1	-0.2	-0.5	0.5	1.1
Condit. Reinf. inactive responses	0.6	0.7	1.8	-1.0	0.0	-0.2	1.4
Condit. Reinf. lever presses	0.9	1.2	2.9	-1.7	1.2	-0.6	0.1
Condit. Reinf. lever reinforcers received	0.2	0.3	0.8	-0.6	-0.1	0.2	0.9
Conditioned reinforcement - actives	0.2	0.2	0.4	0.6	-0.2	-0.5	-0.6
Conditioned reinforcement - inactives	3.3	3.7	9.5	3.1	-2.3	0.2	-0.5
Conditioned locomotion	4.0	4.8	12.5	3.5	-2.3	0.1	-1.0
Patch foraging indifference point 0 sec	0.0	0.1	0.1	0.2	-0.4	0.1	0.2
Patch foraging indifference point AUC	2.0	2.3	4.3	-2.1	1.9	-1.1	-0.4
Delay disc. indifference point, 0s delay	1.3	1.5	2.3	0.3	-1.3	1.4	1.5
Delay disc. indifference point, 16s delay	1.4	1.4	2.0	1.0	-1.4	1.4	0.9
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	0.2	-0.6	0.7	0.3
Delay disc. indifference point, 24s delay	0.0	0.0	0.2	0.1	-0.0	-0.4	-0.0
Delay disc. indifference point, 4s delay	0.5	0.5	1.3	0.0	-0.7	0.4	1.1
Delay disc. indifference point, 8s delay	0.3	0.4	1.1	-0.1	-0.5	0.1	1.1
Indifference point function ln k	4.1	5.7	12.1	3.5	-2.9	1.5	-0.0
Indifference point function log k	4.1	5.7	12.1	3.5	-2.9	1.5	-0.0
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	0.1	-0.0	-0.4	-0.2
Patch foraging total patch changes 12 sec	2.4	3.1	7.3	-2.7	2.0	-0.9	0.3
Patch foraging total patch changes 18 sec	0.3	0.4	0.9	-1.0	0.4	-0.1	0.6
Patch foraging total patch changes 24 sec	2.0	2.5	3.7	-1.9	1.9	-1.5	-0.4
Patch foraging total patch changes 6 sec	0.6	0.9	2.3	-1.5	0.9	-0.5	0.7
Patch foraging time to switch 0 sec	1.3	2.0	3.4	-1.7	0.4	1.2	1.9
Patch foraging water rate 0 sec	2.2	3.6	8.0	2.8	-1.2	-0.8	-2.1
Patch foraging water rate 12 sec	3.3	5.0	13.4	3.7	-2.0	-0.5	-1.6
Patch foraging water rate 18 sec	1.2	1.7	4.5	2.1	-1.4	-0.1	-0.5
Patch foraging water rate 24 sec	1.9	2.6	6.9	2.6	-1.3	-0.2	-1.3
Patch foraging water rate 6 sec	1.5	2.2	5.5	2.3	-1.0	-0.7	-1.3
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.0	0.0	-0.6	0.8	1.0
Distance traveled before self-admin	0.2	0.2	0.4	-0.7	0.5	0.3	-0.1
Distance traveled after self-admin	0.1	0.1	0.1	-0.3	0.4	0.1	-0.1
Extensor digitorum longus weight	3.7	14.7	33.2	-5.8	4.8	-1.6	0.1
Bone: elastic displacement	1.0	1.1	2.1	1.1	0.1	-1.5	-1.1
Bone: elastic work	1.4	1.8	3.1	-1.0	1.6	-1.8	-0.8
Bone: endosteal estimation	2.0	4.4	7.8	1.3	-2.1	2.8	1.9
Bone: endosteal perimeter	2.4	5.0	8.4	1.5	-2.4	2.9	1.9
Epididymis fat weight	1.9	4.3	7.5	2.6	-2.7	1.5	0.8
Delta time in closed arm before/after self-admin	0.3	0.3	0.8	-0.4	0.4	-0.9	0.2
Delta time in open arm before/after self-admin	0.1	0.1	0.5	0.1	0.2	-0.2	-0.7
Diff in mean of infusions in LGA sessions	0.7	0.8	1.5	-0.5	0.9	-1.2	-0.7
Delay discount exponential model param	0.5	0.5	1.3	0.1	0.7	-0.6	-1.1
Extinction: sum of active levers before priming	2.0	2.0	5.2	-2.3	1.5	0.3	0.7
Active lever presses in extinction session 6	2.3	2.2	3.7	-1.3	1.9	-1.3	-1.3
Bone: final force	1.2	2.0	4.7	-2.2	1.7	-0.2	0.3
Bone: final moment	1.1	1.7	4.2	-2.0	1.6	-0.2	0.3
Food consumed during 24 hour testing period	0.5	0.6	1.3	0.1	0.5	-0.9	-1.1
Glucose	2.7	4.0	5.8	1.6	-2.4	2.3	1.7
Heart weight	2.0	2.8	5.0	2.1	-2.2	0.9	0.9
Delay discount hyperbolic model param	0.4	0.5	1.1	0.1	0.6	-0.6	-1.0
Intermittent access intake day 1-15 change	0.8	0.8	1.3	1.1	-0.1	-0.7	-1.2
Intermittent access intake escalation	0.4	0.4	1.0	1.0	-0.3	-0.4	-0.7
Intermittent access intake escalation 2	0.6	0.6	1.5	0.7	0.2	-0.7	-1.2
Intermitt. access day 1 inactive lever presses	1.5	1.6	3.4	1.9	-1.5	0.6	0.1
Intermitt. access day 15 inactive lever presses	1.3	1.4	3.8	1.9	-1.4	0.1	-0.1
Intermitt. access escalation Index	3.3	2.9	4.8	1.5	-2.2	1.5	1.4
Intermittent access day 1 total infusions	5.8	6.7	11.8	2.3	-3.4	2.0	2.3
Intermittent access day 15 total infusions	4.8	5.3	10.4	3.2	-3.1	0.9	0.7
Intermittent access terminal intake (last 3 days)	3.7	4.1	7.6	2.6	-2.7	1.0	0.9
Intermittent access total infusions	3.9	4.4	8.2	2.2	-2.9	1.3	1.6
Intermittent access day 1 locomotion	4.5	4.7	8.0	1.7	-2.8	1.7	2.3
Intermittent access day 15 total locomotion	3.1	3.4	6.2	2.5	-2.5	0.9	0.7
Intermittent access total locomotion	6.0	6.9	12.3	2.6	-3.5	2.1	2.0
Intermittent access standard deviation	0.6	0.7	1.8	1.3	-0.7	-0.5	-0.5
Left kidney weight	0.5	1.5	2.8	1.7	-1.1	1.3	-0.4
Right kidney weight	0.3	0.8	2.0	1.0	-0.1	0.1	-1.4
Cocaine induced anxiety	0.1	0.1	0.3	0.2	0.2	-0.2	-0.6
Post-drug Anxiety	1.3	1.4	2.4	-0.9	1.6	-0.8	-1.3
Baseline Anxiety	1.8	1.9	3.5	-1.6	1.9	-0.9	-0.7
Tail length	1.4	4.3	6.2	-1.2	2.3	-2.5	-2.0
Length with tail	2.2	8.0	12.2	-2.7	3.5	-3.1	-1.7
Length without tail	1.8	4.0	6.3	-2.4	2.5	-2.0	-0.6
Times rat made contact with spout	0.4	0.4	1.0	-1.0	0.4	-0.0	0.8
Lifetime Intake	3.7	4.2	7.7	2.0	-2.8	1.3	1.8
Liver weight, left	0.2	0.3	0.9	0.3	-0.2	1.0	-0.2
Liver weight, right	0.0	0.0	0.0	0.1	-0.1	0.0	0.1
Locomotor activity	0.7	1.1	2.5	1.6	-0.6	-0.9	-0.9
Locomotor testing distance	0.8	1.3	3.2	1.8	-0.8	-0.9	-0.8
Locomotor testing rearing	0.8	1.2	2.6	1.6	-1.2	-0.8	0.3
Locomotion in novel chamber	2.6	3.2	7.5	2.7	-2.2	0.7	-0.4
Locomotion in novel chamber post-restriction	1.5	1.8	4.0	2.0	-1.7	0.6	-0.1
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	0.2	0.0	0.1	-0.5
Change in fecal boli incidents, locomotor task	0.3	0.3	0.8	-0.3	-0.2	0.3	0.9
Time >=10cm from walls, locomotor time 1	2.0	2.0	2.9	0.9	-1.7	1.5	1.4
Bouts of movement, locomotor time 1	0.7	0.8	1.4	-1.1	1.2	-0.8	-0.3
Total resting periods, locomotor time 1	0.4	0.5	0.8	-0.9	0.9	-0.5	-0.2
Rest time, locomotor task time 1	0.7	0.8	1.9	1.4	-0.7	-0.1	-0.8
Distance moved, locomotor task time 1	0.5	0.6	1.3	-0.5	-0.3	0.7	1.2
Vertical activity count, locomotor time 1	0.6	0.6	1.5	1.2	-1.0	0.1	0.0
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	0.0	-0.2	0.6	0.1
Bouts of movement, locomotor time 2	0.2	0.2	0.5	-0.7	0.6	-0.2	0.2
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.5	0.3	0.1	0.4
Rest time, locomotor task time 2	1.4	1.6	3.1	1.8	-1.6	0.7	0.2
Distance moved, locomotor task time 2	0.7	0.8	1.5	-1.2	1.2	-0.5	-0.3
Vertical activity count, locomotor time 2	1.1	1.2	1.9	0.1	0.9	-1.4	-1.4
Light reinforcement 1	0.0	0.1	0.1	0.4	-0.2	-0.3	-0.2
Light reinforcement 2	0.7	1.0	2.0	1.4	-0.9	0.5	-0.9
Bone: marrow area	2.1	4.6	8.4	1.3	-2.2	2.9	1.9
Bone: maximum diameter	0.1	0.1	0.3	-0.1	0.4	0.2	-0.5
Bone: maximum force	1.4	2.5	5.8	-2.4	1.3	0.8	1.3
Bone: maximum moment	1.3	2.2	5.0	-2.2	1.2	0.8	1.3
Mean time between licks in bursts	0.5	0.8	1.5	-1.2	1.1	-0.7	-0.1
Mean num. licks in bursts	0.2	0.2	0.4	0.3	-0.5	0.1	0.6
Cd content in liver	0.8	0.9	2.4	1.6	-0.8	-0.4	-0.7
Co content in liver	0.7	0.9	1.5	1.2	-0.3	-0.9	-1.1
Cu content in liver	0.2	0.2	0.4	-0.6	0.3	0.6	0.2
Fe content in liver	0.2	0.2	0.3	-0.3	0.5	-0.5	-0.6
K content in liver	1.2	1.2	2.2	-1.5	0.5	0.8	1.4
Mg content in liver	2.3	2.3	5.1	-0.6	-0.9	1.8	2.3
Mn content in liver	1.3	1.5	2.8	-1.7	1.5	-1.0	-0.0
Na content in liver	1.0	1.1	1.6	-1.0	1.3	-0.5	-1.2
Rb content in liver	1.9	2.3	3.5	1.2	-1.9	1.4	1.6
Se content in liver	0.2	0.2	0.6	0.2	-0.4	0.2	0.8
Sr content in liver	3.3	3.1	4.3	-1.6	2.1	-1.7	-1.6
Zn content in liver	0.5	0.5	1.3	-1.1	0.8	0.1	0.4
Bone: minimum diameter	2.7	5.1	9.0	1.0	-2.1	3.0	2.4
Time in familiar zone, hab. session 1	0.5	0.4	0.7	0.4	-0.7	0.8	0.6
Time in novel zone, hab. session 1	0.4	0.4	1.0	0.3	0.1	-1.0	-0.7
Total zone transitions, hab. session 1	0.3	0.4	1.1	-1.0	0.7	0.2	0.3
Total locomotion distance, hab. session 1	0.7	1.0	2.2	0.7	-1.0	1.5	0.6
Locomotion velocity, hab. session 1	0.4	0.5	1.5	0.2	-0.5	1.2	0.6
Time in familiar zone, hab. session 2	0.5	0.5	1.5	-0.1	0.5	-1.2	-0.4
Time in novel zone, hab. session 2	0.5	0.5	1.2	-0.2	-0.4	1.1	0.8
Total zone transitions, hab. session 2	2.3	2.9	6.9	-1.7	-0.1	1.4	2.6
Total locomotion distance, hab. session 2	1.6	2.1	3.8	-0.2	-1.0	2.0	1.9
Locomotion velocity, hab. session 2	1.7	2.3	4.5	0.1	-1.2	2.1	1.8
Novel to familiar place preference ratio	0.3	0.3	0.8	-0.9	0.5	0.3	0.1
Novelty place preference	0.1	0.1	0.3	-0.5	0.1	0.4	0.2
Time in novel zone, NPP test	0.1	0.1	0.2	-0.4	0.0	0.3	0.2
Total zone transitions, NPP test	1.1	1.6	3.8	-2.0	1.0	0.5	1.2
Total locomotion distance, NPP test	0.6	0.8	2.0	-0.3	-0.4	1.4	1.0
Locomotion velocity, NPP test	0.5	0.7	2.0	-0.3	-0.3	1.4	0.8
Intraocular pressure	1.1	1.5	2.4	1.6	-0.4	-1.2	-1.4
Delta distance traveled before/after self-admin	0.1	0.1	0.3	0.2	0.1	-0.6	-0.1
Delta ambulatory time before/after self-admin	0.1	0.1	0.5	0.0	0.2	-0.7	-0.1
Parametrial fat weight	3.2	6.2	9.2	2.2	-2.8	3.0	1.7
Pavlov. Cond. lever latency	0.1	0.1	0.3	0.5	-0.2	-0.4	-0.3
Pavlov. Cond. magazine entry latency	0.7	0.9	1.9	-0.4	-0.5	1.4	1.1
Pavlov. Cond. change in total contacts	0.4	0.4	1.5	0.0	-0.4	1.2	0.2
Pavlov. Cond. index score	0.0	0.1	0.1	-0.2	0.1	0.4	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.2	-0.1	0.6	0.1
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.1	-0.1	0.3	0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.3	-0.3	-0.0	0.6
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.8	0.9	-0.2	-0.4	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.5	0.2	0.5	-0.0
Pavlov. Cond. response bias	0.0	0.1	0.2	-0.1	0.1	0.1	-0.4
Pavlov. Cond. lever latency	0.2	0.2	0.5	0.7	-0.6	0.2	0.1
Pavlov. Cond. magazine entry latency	1.7	1.9	5.3	-2.3	1.4	-0.0	0.7
Pavlov. Cond. change in total contacts	0.6	0.8	2.0	-1.4	0.8	0.5	0.4
Pavlov. Cond. index score	0.9	1.1	3.1	-1.8	1.2	0.1	0.3
Pavlov. Cond. latency score	0.7	0.9	2.4	-1.5	1.0	0.3	0.3
Pavlov. Cond. lever contacts	0.4	0.6	0.8	-0.7	0.9	-0.9	-0.7
Pavlov. Cond. magazine entry number	2.8	3.4	9.1	3.0	-2.1	0.2	-0.6
Pavlov. Cond. intertrial magazine entries	0.6	0.8	1.9	1.4	-1.1	0.3	-0.3
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	3.9	-2.0	1.3	0.0	0.4
Pavlov. Cond. response bias	0.8	1.1	2.4	-1.6	1.2	-0.6	-0.2
Time in closed arm before self-admin	0.1	0.1	0.4	-0.1	-0.2	0.7	0.1
Time in closed arm after self-admin	0.1	0.1	0.2	0.0	-0.1	0.2	0.4
Time in open arm before self-admin	0.1	0.2	0.3	0.4	-0.5	-0.1	0.5
Time in open arm after self-admin	0.3	0.3	0.5	0.5	0.0	-0.7	-0.7
Bone: periosteal estimation	0.3	0.6	1.8	0.3	-0.5	1.3	0.5
Bone: periosteal perimeter	0.1	0.2	0.6	-0.2	-0.1	0.8	0.6
Bone: post-yield work	6.0	8.2	17.7	-0.7	-1.7	4.2	3.5
Progressive ratio test 1 active lever presses	1.5	1.6	3.3	1.8	-1.7	0.1	0.3
Progressive ratio test 1 breakpoint	1.3	1.3	3.0	1.7	-1.5	-0.1	0.1
Progressive ratio test 1 inactive lever presses	0.8	0.8	1.6	1.1	-1.3	0.3	0.6
Progressive ratio test 2 active lever presses	2.4	2.6	5.2	2.3	-2.2	0.4	0.4
Progressive ratio test 2 breakpoint	2.6	3.0	7.1	2.7	-2.2	0.1	-0.0
Progressive ratio test 2 inactive lever presses	5.5	6.4	11.6	3.4	-3.4	1.2	0.9
Incentive Sensitization - Responses	0.3	0.3	0.6	0.7	-0.8	0.2	0.4
Incentive Sensitization - Breakpoint	0.4	0.4	0.8	0.9	-0.9	0.3	0.3
Sum of active levers in priming session hrs 5-6	3.0	2.9	4.9	-0.7	1.9	-1.6	-2.2
Progressive ratio	2.1	2.4	4.2	-1.8	0.1	1.5	2.1
Food seeking constrained by brief footshock	0.2	0.3	0.5	-0.6	0.7	-0.6	-0.1
Seeking ratio, punishment vs. effort	1.2	1.4	2.2	1.5	-0.2	-1.2	-1.4
Retroperitoneal fat weight	3.7	12.3	20.4	4.5	-4.4	2.9	1.0
Reaction time number correct	0.8	1.1	2.1	-0.6	1.1	-1.5	-0.9
Reaction time mean minus median	1.2	1.6	3.6	-1.9	1.6	-0.5	-0.2
Reaction time mean minus median AUC	1.1	1.5	2.3	-1.4	1.5	-1.0	-0.8
Reaction time num false alarms	0.1	0.2	0.4	0.4	0.1	-0.3	-0.6
Reaction time num false alarms AUC	0.2	0.3	0.5	-0.3	0.7	-0.6	-0.6
Reaction time trials correct on left	0.8	1.1	2.1	-0.6	1.1	-1.5	-0.9
Reaction time trials on left	0.9	1.3	2.5	-0.7	1.2	-1.6	-1.0
Reaction time mean	0.0	0.1	0.2	-0.0	0.0	0.1	-0.4
Reaction time mean AUC	0.1	0.1	0.2	0.0	-0.1	0.4	-0.3
Median of all reaction times	0.1	0.2	0.3	0.4	-0.5	0.5	-0.2
Reaction time omissions	0.8	1.1	1.7	-1.3	1.3	-0.8	-0.6
Reaction time false alarm rate	0.0	0.1	0.1	0.3	-0.1	0.2	-0.3
Reaction time premature initiation rate	2.1	2.8	4.4	-2.1	2.0	-1.5	-0.7
Reaction time premature initiations	4.0	5.6	8.1	-2.6	2.8	-2.4	-1.3
Std. dev. reaction times	0.3	0.5	0.8	-0.9	0.8	-0.4	-0.5
Reaction time trials completed	0.9	1.3	2.5	-0.7	1.2	-1.6	-1.0
Reaction time trials AUC	0.7	1.0	1.9	-0.5	1.0	-1.4	-0.8
Run reversals in cocaine runway, females	1.3	1.3	2.6	-1.0	-0.2	1.2	1.6
Run reversals in cocaine runway, males	1.8	1.7	3.7	0.7	0.6	-1.5	-1.9
Latency to leave start box in cocaine runway	0.7	0.8	1.5	0.0	-0.7	1.2	1.0
Latency to leave start box in cocaine runway, F	0.4	0.4	1.0	-0.1	-0.5	1.0	0.7
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.1	-0.1	0.2	0.1
Std. dev. time between licks in bursts	0.2	0.2	0.4	-0.0	0.5	-0.6	-0.6
Total sessions with >9 infusions	1.6	1.7	3.1	1.2	-1.8	1.0	1.2
Short access day 1 total inactive lever presses	2.5	2.7	4.9	2.1	-2.2	1.0	0.7
Short access day 10 total inactive lever presses	1.6	1.8	4.3	2.1	-1.7	0.4	0.1
Short access day 1 total infusions	3.9	4.2	6.8	1.5	-2.6	1.9	2.0
Short access day 10 total infusions	3.9	4.3	7.7	0.8	-2.4	1.8	2.8
Short access total infusions	2.2	2.5	3.9	0.9	-2.0	1.3	1.9
Short access day 1 locomotion	2.7	2.9	5.0	1.4	-2.2	1.2	1.8
Short access day 10 total locomotion	2.4	2.7	4.1	1.1	-2.0	1.3	1.9
Short access total locomotion	2.2	2.3	3.5	0.9	-1.9	1.3	1.8
One hour access (0.3 mA shock)	5.2	6.1	13.8	3.7	-3.2	0.4	0.4
Compulsive drug intake	2.3	2.3	4.0	-1.8	2.0	-1.3	-0.5
One hour access (shock baseline)	5.2	6.0	13.1	3.6	-3.2	0.8	0.2
Social response proportion	0.5	0.5	1.2	-1.1	0.7	-0.4	0.4
Social responses	0.4	0.5	1.1	-0.6	0.8	-1.1	-0.1
Social time	0.5	0.6	0.9	-0.7	0.9	-0.9	-0.4
Soleus weight	2.4	7.0	15.1	3.9	-3.0	1.9	-0.0
Bone: stiffness	1.2	1.9	4.2	-2.1	0.9	1.0	1.3
Tibialis anterior weight	7.0	24.1	39.9	-6.1	6.3	-3.8	-2.1
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.6	-0.8	0.2	0.3	0.7
Time to tail flick, vehicle, after self-admin	0.9	1.0	2.3	-1.5	0.6	0.2	1.1
Time to tail flick, test, before self-admin	1.8	1.8	3.6	0.4	-1.4	1.2	1.9
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.1	0.2	-0.4	-0.3
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.7	-0.8	0.4	0.0	0.7
Delta time to tail flick, test, before/after SA	3.6	3.3	5.1	-0.7	1.9	-2.0	-2.3
Tibia length	0.7	2.0	3.7	-1.2	1.9	-0.7	-1.6
Ambulatory time before self-admin	0.1	0.1	0.2	-0.4	0.4	0.2	-0.2
Ambulatory time after self-admin	0.3	0.4	0.7	0.4	-0.6	0.8	0.5
Bone: tissue strength	0.1	0.1	0.2	-0.1	-0.1	0.4	0.4
Total heroin consumption	2.8	3.3	7.5	-2.7	2.3	-0.5	-0.1
Bone: trabecular number	0.7	1.1	3.2	-0.8	-0.3	0.6	1.8
Bone: trabecular spacing	0.0	0.1	0.1	0.3	-0.1	0.2	-0.3
Bone: trabecular thickness	0.9	1.1	1.6	0.7	-1.3	0.9	1.2
Bone: trabecular tissue density	1.9	2.6	6.4	2.5	-1.7	1.0	-0.6
Water consumed over 24 hours	0.7	0.9	1.4	-1.1	0.9	-1.2	-0.0
Number of responses in last shaping day	0.5	0.5	1.3	1.1	-0.7	-0.5	-0.3