Cst6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Cst6	0.09	0.07	1.0e-04	0.05	0.04	0.04	0.04	6.7e-05	2.6e-04	1.9e-04	1.5e-04
2	BLA	gene expression	Cst6	0.21	0.11	1.6e-10	0.21	0.2	0.18	0.2	3.0e-11	7.4e-11	4.6e-10	4.6e-11
3	NAcc	gene expression	Cst6	0.03	0.02	7.2e-04	0.01	0.01	0.01	0.01	1.8e-02	5.6e-03	1.0e-02	2.1e-02
4	Brain	gene expression	Cst6	0.04	0.04	6.2e-03	0.02	0	0.01	0	5.9e-03	1.1e-01	4.3e-02	1.7e-01
5	Adipose	gene expression	Cst6	0.36	0.12	0.0e+00	0.18	0.22	0.22	0.22	6.3e-20	1.6e-23	6.3e-24	1.0e-23

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.8	1.4	4.3	-1.0	1.0	0.3	-0.8	2.1
Area under the delay curve	0.5	0.6	2.2	0.2	-0.3	-0.7	-0.4	1.5
BMI with tail	1.9	6.4	14.3	-2.8	2.5	1.2	-1.6	3.8
BMI without tail	1.0	3.0	7.5	-1.9	1.6	0.7	-0.9	2.7
Body weight	1.9	8.2	15.1	-3.9	3.6	3.0	1.1	1.6
Weight adjusted by age	1.4	2.1	2.9	-1.6	1.4	1.7	1.6	-0.8
Bone surface	3.1	5.6	9.9	-3.2	3.1	2.5	0.7	1.3
Bone volume	1.2	2.1	3.5	-1.9	1.8	1.3	-0.4	1.4
Breakpoint value in progressive ratio session	2.6	3.2	5.2	-2.3	2.2	2.1	1.1	-0.2
Number of licking bursts	0.3	0.4	0.8	-0.9	0.8	0.8	0.4	-0.2
Context. condit. distance diff. score	1.8	2.2	3.3	1.8	-1.8	-1.7	-1.1	0.5
Locomotion velocity, session 1	0.1	0.1	0.5	0.0	-0.0	0.0	0.7	-0.2
Locomotion distance, session 1	0.7	0.9	3.2	-0.8	0.8	0.2	-0.2	1.8
Locomotion velocity, session 2	1.9	2.2	4.0	-1.9	2.0	1.5	0.6	0.7
Locomotion distance, session 2	0.7	1.0	2.2	-1.1	1.0	0.5	-0.0	1.5
Locomotion velocity, session 3	0.4	0.4	1.1	0.4	-0.3	-0.6	-0.7	1.1
Locomotion distance, session 3	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1
Stereotopy head waving bouts, day 3	1.2	1.4	1.9	1.1	-1.1	-1.4	-1.0	1.3
Stereotopy head waving duration, day 3	1.2	1.5	1.9	1.3	-1.3	-1.4	-1.1	1.0
Locomotion velocity, session 7	1.3	1.4	3.1	0.5	-0.5	-0.9	-1.8	1.6
Locomotion distance, session 7	0.3	0.4	1.4	-0.0	-0.1	-0.4	-0.5	1.2
Stereotopy head waving bouts, day 7	0.2	0.3	0.8	0.3	-0.1	-0.2	-0.9	0.6
Stereotopy head waving duration, day 7	0.4	0.5	0.8	-0.7	0.9	0.7	-0.4	0.7
Locomotion velocity, session 8	1.1	1.3	2.7	-1.1	1.1	1.1	1.6	-0.2
Locomotion distance, session 8	0.5	0.7	1.1	0.6	-0.7	-0.9	-1.0	1.0
Degree of sensitization distance	0.4	0.4	1.3	-0.1	-0.0	-0.3	-0.7	1.1
Degree of sensitization stereotypy	0.3	0.3	0.6	-0.6	0.8	0.7	-0.4	0.1
Conditioned locomotion	1.4	1.6	2.0	-1.4	1.4	1.4	1.3	-0.3
Cocaine response after cond. corrected	1.0	1.2	2.0	1.4	-1.3	-1.3	-0.5	0.3
Cocaine response after cond. not corrected	0.7	0.8	1.3	1.1	-1.1	-1.1	-0.5	0.2
Cocaine response before conditioning	0.6	0.8	1.4	-1.2	1.0	1.1	0.1	-0.4
Saline control response	3.2	4.2	6.5	-2.5	2.6	2.2	1.8	0.3
Bone: connectivity density	1.9	3.0	4.8	-2.2	2.1	1.4	0.1	2.0
Bone: cortical apparent density	0.2	0.2	0.3	-0.3	0.4	0.5	0.6	-0.6
Bone: cortical area	0.8	1.3	1.9	-1.4	1.3	1.3	0.7	-0.7
Bone: cortical porosity	0.2	0.2	0.6	-0.4	0.3	0.1	-0.2	0.8
Bone: cortical porosity	0.3	0.3	0.6	-0.7	0.7	0.4	0.1	0.7
Bone: cortical thickness	3.7	6.1	7.8	-2.6	2.6	2.8	2.5	-1.7
Bone: cortical thickness	1.1	1.3	2.6	-1.0	1.0	1.0	1.6	-0.8
Bone: cortical tissue density	0.3	0.4	0.6	-0.4	0.5	0.6	0.8	-0.6
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	-0.3	0.5	0.4	-0.3	0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.1	0.1	0.2	-0.3	0.4
Condit. Reinf. active responses	0.2	0.3	0.5	-0.2	0.4	0.2	-0.7	0.7
Condit. Reinf. inactive responses	0.2	0.2	0.8	0.1	-0.0	-0.3	-0.9	0.6
Incentive salience index mean	0.4	0.5	1.1	-0.6	0.7	0.4	-0.6	1.0
Condit. Reinf. lever presses	0.3	0.5	0.8	-0.9	0.9	0.7	-0.4	0.4
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	0.1	-0.1	-0.2	-0.7	0.2
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.9	0.7	-0.7	-0.7	-1.4	0.1
Condit. Reinf. active responses	0.2	0.2	0.6	-0.5	0.5	0.2	-0.4	0.8
Condit. Reinf. inactive responses	0.5	0.6	1.3	-0.9	0.8	0.4	0.4	1.1
Condit. Reinf. lever presses	1.6	2.2	4.0	-1.9	2.0	1.8	0.6	0.1
Condit. Reinf. lever reinforcers received	0.3	0.4	0.6	-0.8	0.8	0.5	-0.1	0.6
Conditioned reinforcement - actives	0.2	0.4	1.6	-0.2	0.1	0.4	0.2	-1.3
Conditioned reinforcement - inactives	1.6	2.3	3.6	1.9	-1.8	-1.6	-1.2	-0.7
Conditioned locomotion	5.2	6.8	10.8	3.3	-3.3	-2.9	-1.8	-0.9
Patch foraging indifference point 0 sec	0.1	0.1	0.2	0.1	-0.3	-0.3	-0.5	0.5
Patch foraging indifference point AUC	2.0	2.8	4.2	-1.9	2.0	2.1	1.2	-0.8
Delay disc. indifference point, 0s delay	1.5	1.6	3.3	0.8	-1.0	-1.4	-1.1	1.8
Delay disc. indifference point, 16s delay	0.7	0.8	1.0	0.8	-0.8	-1.0	-0.9	0.9
Delay disc. indifference point, 2s delay	0.2	0.2	0.4	0.4	-0.1	-0.6	-0.5	0.7
Delay disc. indifference point, 24s delay	0.2	0.2	0.6	0.3	-0.5	-0.3	0.8	0.1
Delay disc. indifference point, 4s delay	0.6	0.6	1.9	0.4	-0.4	-0.8	-0.2	1.4
Delay disc. indifference point, 8s delay	0.3	0.4	1.3	0.2	-0.5	-0.6	-0.1	1.1
Indifference point function ln k	4.9	8.6	13.6	3.6	-3.7	-3.6	-1.8	0.4
Indifference point function log k	4.9	8.6	13.6	3.6	-3.7	-3.6	-1.8	0.4
Patch foraging total patch changes 0 sec	0.0	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1
Patch foraging total patch changes 12 sec	3.5	4.5	7.8	-2.8	2.7	2.4	1.3	0.4
Patch foraging total patch changes 18 sec	0.4	0.6	1.1	-1.0	1.0	0.8	-0.0	0.4
Patch foraging total patch changes 24 sec	1.3	2.3	3.4	-1.7	1.6	1.9	1.4	-0.6
Patch foraging total patch changes 6 sec	0.9	1.3	2.3	-1.5	1.5	1.2	0.4	0.7
Patch foraging time to switch 0 sec	1.0	2.0	2.9	-1.7	1.6	1.1	-0.8	1.7
Patch foraging water rate 0 sec	2.1	4.4	7.4	2.7	-2.7	-2.0	0.0	-1.8
Patch foraging water rate 12 sec	4.2	8.8	15.5	3.9	-3.9	-3.3	-0.0	-1.4
Patch foraging water rate 18 sec	1.8	2.7	5.2	2.3	-2.1	-2.0	-0.3	-0.4
Patch foraging water rate 24 sec	3.1	4.4	8.1	2.8	-2.7	-2.2	-0.2	-1.2
Patch foraging water rate 6 sec	2.6	3.8	6.7	2.6	-2.5	-2.1	0.5	-1.2
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.9	0.3	-0.3	-0.5	-0.7	1.4
Distance traveled before self-admin	0.4	0.5	0.9	-0.9	0.9	0.6	-0.5	0.4
Distance traveled after self-admin	0.2	0.2	0.5	-0.7	0.5	0.6	-0.4	-0.1
Extensor digitorum longus weight	5.6	22.1	35.2	-5.9	5.9	5.5	3.1	-0.1
Bone: elastic displacement	0.7	0.8	1.3	0.9	-0.9	-0.4	0.9	-1.2
Bone: elastic work	1.2	1.6	2.7	-1.3	1.2	1.3	1.7	-0.7
Bone: endosteal estimation	1.3	2.9	4.3	1.2	-1.4	-1.8	-2.1	1.9
Bone: endosteal perimeter	1.6	3.3	6.1	1.3	-1.5	-1.8	-2.5	1.8
Epididymis fat weight	2.7	9.1	13.6	3.6	-3.7	-3.4	-2.8	-0.2
Delta time in closed arm before/after self-admin	0.3	0.3	0.9	-0.3	0.4	0.2	1.0	0.4
Delta time in open arm before/after self-admin	0.3	0.3	0.7	-0.5	0.3	0.7	-0.4	-0.8
Diff in mean of infusions in LGA sessions	0.7	0.8	1.5	-0.9	1.2	1.1	0.6	-0.5
Delay discount exponential model param	0.4	0.4	1.6	-0.1	0.2	0.5	0.2	-1.3
Extinction: sum of active levers before priming	1.9	2.1	3.9	-2.0	2.0	1.5	0.3	0.7
Active lever presses in extinction session 6	2.8	2.8	4.3	-2.0	1.9	2.1	1.1	-0.8
Bone: final force	1.8	2.9	4.7	-2.2	2.1	1.9	1.2	0.1
Bone: final moment	1.6	2.6	4.3	-2.1	2.1	1.8	1.2	0.1
Food consumed during 24 hour testing period	0.4	0.5	1.9	-0.1	0.2	0.5	0.7	-1.4
Glucose	3.3	5.2	6.6	2.0	-2.1	-2.6	-2.5	2.1
Heart weight	2.6	4.0	8.1	1.4	-1.4	-2.1	-1.9	2.9
Delay discount hyperbolic model param	0.4	0.4	1.6	-0.2	0.2	0.5	0.3	-1.3
Intermittent access intake day 1-15 change	0.6	1.2	2.0	1.4	-1.3	-0.9	-0.7	-0.9
Intermittent access intake escalation	0.5	1.0	1.6	1.2	-1.2	-0.7	-0.6	-1.2
Intermittent access intake escalation 2	1.0	1.1	1.6	1.2	-1.2	-0.7	-0.7	-1.2
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.3	0.5	-0.5	-0.2	-0.3	-0.3
Intermitt. access day 15 inactive lever presses	0.7	1.5	2.6	1.5	-1.2	-1.2	-1.6	0.0
Intermitt. access escalation Index	2.4	3.4	5.8	2.0	-2.0	-2.4	-1.6	1.0
Intermittent access day 1 total infusions	3.0	4.8	8.4	1.7	-1.7	-2.3	-2.9	2.0
Intermittent access day 15 total infusions	3.3	5.0	6.6	2.5	-2.4	-2.5	-2.6	0.1
Intermittent access terminal intake (last 3 days)	3.5	4.6	7.6	2.3	-2.2	-2.3	-2.8	0.4
Intermittent access total infusions	3.3	3.9	7.2	1.8	-1.7	-2.1	-2.7	1.1
Intermittent access day 1 locomotion	2.5	3.1	5.4	1.5	-1.5	-1.9	-2.3	1.5
Intermittent access day 15 total locomotion	2.3	4.1	6.3	2.3	-2.1	-2.2	-2.5	0.3
Intermittent access total locomotion	6.1	7.3	12.2	2.8	-2.6	-2.9	-3.5	1.1
Intermittent access standard deviation	0.6	1.3	2.3	1.5	-1.3	-1.1	-0.8	-0.7
Left kidney weight	0.8	3.9	5.9	2.1	-2.1	-2.1	-2.4	0.5
Right kidney weight	0.3	1.4	2.1	1.4	-1.4	-1.3	-0.9	-0.6
Cocaine induced anxiety	0.1	0.1	0.1	-0.4	0.1	0.3	-0.4	-0.3
Post-drug Anxiety	0.7	0.7	1.3	-1.2	0.8	1.0	0.6	-0.4
Baseline Anxiety	0.5	0.6	1.9	-0.6	0.6	0.6	1.4	-0.3
Tail length	0.5	1.9	3.5	-1.2	1.2	1.5	1.9	-1.0
Length with tail	1.7	7.5	9.7	-3.0	2.9	3.1	3.0	-1.2
Length without tail	2.1	6.6	9.7	-2.7	2.6	2.8	3.1	-1.1
Times rat made contact with spout	0.4	0.5	0.7	-0.7	0.8	0.5	0.6	0.7
Lifetime Intake	2.4	2.9	5.1	1.5	-1.4	-1.9	-2.3	1.2
Liver weight, left	0.6	1.0	1.8	1.3	-1.3	-1.2	-0.3	-0.3
Liver weight, right	1.6	2.8	4.6	2.1	-2.2	-2.1	-0.5	0.2
Locomotor activity	1.1	1.7	3.0	1.7	-1.6	-1.5	0.5	-0.7
Locomotor testing distance	1.2	2.2	3.9	2.0	-1.8	-1.8	0.5	-0.6
Locomotor testing rearing	1.1	2.2	3.9	2.0	-1.7	-2.0	-0.0	0.2
Locomotion in novel chamber	4.1	5.3	7.8	2.8	-2.8	-2.6	-2.0	-0.1
Locomotion in novel chamber post-restriction	1.9	3.1	4.6	2.1	-1.9	-2.0	-1.7	-0.1
Fecal boli incidents, locomotor time 1	0.1	0.2	0.5	0.0	0.2	0.3	-0.5	-0.7
Change in fecal boli incidents, locomotor task	0.3	0.3	1.3	-0.1	-0.2	-0.4	0.2	1.1
Time >=10cm from walls, locomotor time 1	1.8	1.9	4.8	0.8	-0.9	-1.1	-2.2	1.4
Bouts of movement, locomotor time 1	1.2	1.4	2.4	-1.4	1.2	1.5	1.0	-0.5
Total resting periods, locomotor time 1	0.8	0.9	1.5	-1.1	1.0	1.2	0.6	-0.3
Rest time, locomotor task time 1	1.0	1.3	2.3	1.5	-1.3	-1.1	-0.8	-0.7
Distance moved, locomotor task time 1	0.3	0.5	1.7	-0.5	0.4	0.0	-0.5	1.3
Vertical activity count, locomotor time 1	0.3	0.7	1.1	1.0	-1.1	-1.0	-0.5	0.2
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.3	-0.2	-0.1	0.1	-0.5	-0.2
Bouts of movement, locomotor time 2	0.3	0.5	0.7	-0.9	0.7	0.8	0.7	0.3
Total resting periods, locomotor time 2	0.1	0.2	0.3	-0.6	0.4	0.4	0.2	0.4
Rest time, locomotor task time 2	2.0	2.6	3.8	1.9	-1.9	-1.8	-1.4	0.3
Distance moved, locomotor task time 2	1.1	1.3	1.9	-1.3	1.2	1.4	1.1	-0.4
Vertical activity count, locomotor time 2	0.5	0.7	1.8	-0.1	-0.0	0.5	1.2	-1.3
Light reinforcement 1	0.0	0.1	0.2	0.4	-0.2	-0.4	0.2	-0.2
Light reinforcement 2	0.4	0.6	0.9	1.0	-0.9	-0.7	-0.6	-0.7
Bone: marrow area	1.5	3.2	4.6	1.3	-1.5	-1.9	-2.2	2.0
Bone: maximum diameter	0.1	0.3	0.4	-0.6	0.5	0.6	0.1	-0.6
Bone: maximum force	2.3	4.0	7.1	-2.7	2.7	2.1	0.5	1.0
Bone: maximum moment	2.1	3.6	6.5	-2.6	2.5	2.0	0.5	1.0
Mean time between licks in bursts	0.2	0.5	1.5	-0.6	0.6	0.5	1.2	0.0
Mean num. licks in bursts	0.2	0.4	0.5	0.7	-0.6	-0.7	-0.3	0.6
Cd content in liver	1.0	1.1	1.5	1.2	-1.1	-1.1	-1.2	-0.2
Co content in liver	1.1	1.3	2.0	1.3	-1.4	-1.0	0.5	-1.2
Cu content in liver	0.2	0.2	0.5	-0.1	0.1	-0.2	-0.7	0.6
Fe content in liver	0.3	0.4	0.8	-0.5	0.5	0.6	0.9	-0.6
K content in liver	0.5	0.5	1.1	-0.7	0.7	0.4	-0.1	1.1
Mg content in liver	0.6	0.6	1.0	0.6	-0.6	-0.8	-0.8	1.0
Mn content in liver	2.9	3.2	5.2	-2.1	2.2	2.3	1.1	-0.4
Na content in liver	0.8	0.8	1.4	-0.7	0.7	0.9	0.9	-1.2
Rb content in liver	1.8	2.0	3.1	1.5	-1.5	-1.8	-1.2	1.1
Se content in liver	0.1	0.1	0.2	0.2	-0.2	-0.2	-0.4	-0.0
Sr content in liver	2.8	2.4	3.3	-1.6	1.6	1.8	1.5	-1.1
Zn content in liver	0.2	0.2	0.3	-0.6	0.5	0.4	-0.1	0.4
Bone: minimum diameter	1.8	3.2	6.0	0.9	-1.1	-1.6	-2.5	2.3
Time in familiar zone, hab. session 1	0.4	0.4	0.8	0.4	-0.3	-0.6	-0.9	0.6
Time in novel zone, hab. session 1	0.4	0.4	0.7	0.5	-0.6	-0.3	0.9	-0.6
Total zone transitions, hab. session 1	0.5	0.7	1.3	-1.1	1.1	0.9	0.1	0.4
Total locomotion distance, hab. session 1	0.5	0.8	1.4	0.7	-0.7	-0.8	-1.2	0.8
Locomotion velocity, hab. session 1	0.2	0.3	0.7	0.2	-0.2	-0.3	-0.8	0.7
Time in familiar zone, hab. session 2	0.2	0.2	1.1	0.0	-0.0	0.1	1.0	-0.4
Time in novel zone, hab. session 2	0.3	0.3	0.7	-0.2	0.2	-0.1	-0.7	0.8
Total zone transitions, hab. session 2	1.6	2.0	6.0	-1.4	1.3	0.5	-0.6	2.4
Total locomotion distance, hab. session 2	1.0	1.3	4.2	0.2	-0.2	-0.7	-1.2	2.1
Locomotion velocity, hab. session 2	1.0	1.4	3.8	0.3	-0.4	-0.9	-1.5	2.0
Novel to familiar place preference ratio	0.7	0.7	1.3	-1.1	1.1	1.0	-0.1	0.0
Novelty place preference	0.3	0.3	0.5	-0.7	0.7	0.6	-0.3	0.1
Time in novel zone, NPP test	0.2	0.2	0.4	-0.6	0.6	0.5	-0.3	0.2
Total zone transitions, NPP test	1.4	2.1	3.7	-1.9	1.8	1.4	0.3	1.2
Total locomotion distance, NPP test	0.3	0.4	1.6	-0.2	0.1	-0.2	-0.7	1.2
Locomotion velocity, NPP test	0.3	0.4	1.3	-0.3	0.3	-0.1	-0.7	1.1
Intraocular pressure	1.0	1.4	2.7	1.3	-1.5	-0.6	-0.2	-1.6
Delta distance traveled before/after self-admin	0.1	0.1	0.1	0.3	-0.3	-0.1	0.3	-0.4
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	0.1	-0.1	0.1	0.6	-0.3
Parametrial fat weight	3.6	8.4	11.5	3.2	-3.4	-3.2	-3.1	0.7
Pavlov. Cond. lever latency	0.2	0.2	0.4	0.6	-0.6	-0.4	0.2	-0.4
Pavlov. Cond. magazine entry latency	0.3	0.4	1.0	-0.4	0.4	0.1	-0.9	1.0
Pavlov. Cond. change in total contacts	0.2	0.2	0.8	-0.3	0.3	0.3	-0.9	0.2
Pavlov. Cond. index score	0.1	0.1	0.3	-0.5	0.5	0.4	-0.2	-0.0
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.3	0.3	0.2	-0.4	0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.4	0.3	0.1	-0.4	0.5
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	0.6	-0.6	-0.7	-0.0	0.4
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.4	0.4	-0.4	-0.3	-0.3	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.4	-0.6	0.6	0.5	-0.3	0.2
Pavlov. Cond. response bias	0.2	0.2	0.3	-0.6	0.5	0.6	-0.1	-0.3
Pavlov. Cond. lever latency	0.6	0.8	1.2	1.0	-1.0	-1.1	-0.5	0.7
Pavlov. Cond. magazine entry latency	3.4	4.1	7.2	-2.7	2.7	2.3	0.9	0.6
Pavlov. Cond. change in total contacts	1.1	1.8	3.3	-1.8	1.8	1.6	0.0	0.0
Pavlov. Cond. index score	1.9	2.6	4.7	-2.1	2.2	1.9	0.5	0.1
Pavlov. Cond. latency score	1.7	2.2	4.0	-2.0	2.0	1.8	0.3	0.0
Pavlov. Cond. lever contacts	0.6	0.8	1.2	-1.0	1.1	1.1	0.4	-0.6
Pavlov. Cond. magazine entry number	5.5	6.7	11.4	3.3	-3.4	-3.0	-1.3	-0.3
Pavlov. Cond. intertrial magazine entries	0.7	1.1	1.9	1.3	-1.4	-1.2	-0.7	-0.2
Pavlov. Cond. lever-magazine prob. diff.	2.4	3.2	5.5	-2.3	2.4	2.1	0.6	0.1
Pavlov. Cond. response bias	1.6	2.2	3.8	-1.9	1.9	1.7	0.6	-0.0
Time in closed arm before self-admin	0.3	0.4	0.8	0.4	-0.8	-0.6	-0.9	0.3
Time in closed arm after self-admin	0.2	0.2	0.3	0.3	-0.6	-0.5	-0.1	0.5
Time in open arm before self-admin	0.2	0.3	0.5	0.7	-0.2	-0.6	0.5	0.5
Time in open arm after self-admin	0.1	0.1	0.1	-0.1	0.2	0.2	0.1	-0.4
Bone: periosteal estimation	0.1	0.2	0.7	-0.1	-0.0	-0.2	-0.9	0.5
Bone: periosteal perimeter	0.1	0.2	0.4	-0.5	0.4	0.2	-0.5	0.6
Bone: post-yield work	2.9	4.3	11.5	-0.9	0.9	-0.1	-2.9	3.4
Progressive ratio test 1 active lever presses	0.1	0.2	0.5	0.3	-0.2	-0.4	-0.7	0.0
Progressive ratio test 1 breakpoint	0.1	0.1	0.4	0.3	-0.1	-0.3	-0.6	-0.0
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	0.3	-0.1	-0.1	-0.2	-0.0
Progressive ratio test 2 active lever presses	1.5	1.8	2.6	1.5	-1.4	-1.4	-1.6	0.0
Progressive ratio test 2 breakpoint	1.4	1.6	2.3	1.5	-1.3	-1.4	-1.5	-0.1
Progressive ratio test 2 inactive lever presses	4.5	7.4	10.0	3.2	-3.1	-3.1	-2.7	0.3
Incentive Sensitization - Responses	0.1	0.2	0.7	-0.1	0.1	-0.1	-0.8	0.6
Incentive Sensitization - Breakpoint	0.2	0.2	0.8	0.1	-0.1	-0.3	-0.9	0.6
Sum of active levers in priming session hrs 5-6	3.9	3.7	7.6	-1.2	1.5	2.0	1.7	-2.8
Progressive ratio	1.0	1.6	5.4	-0.9	0.9	0.3	-0.9	2.3
Food seeking constrained by brief footshock	0.1	0.2	0.5	-0.3	0.4	0.4	0.7	0.1
Seeking ratio, punishment vs. effort	0.8	1.1	1.9	1.1	-1.1	-0.8	0.7	-1.4
Retroperitoneal fat weight	7.4	31.5	46.8	6.8	-6.8	-6.8	-4.2	0.7
Reaction time number correct	0.4	0.7	1.3	-0.6	0.6	0.8	1.2	-1.0
Reaction time mean minus median	1.2	3.1	5.3	-2.3	2.1	2.3	0.6	-0.4
Reaction time mean minus median AUC	0.8	2.0	3.4	-1.7	1.5	1.9	0.9	-0.9
Reaction time num false alarms	0.1	0.2	0.3	0.6	-0.4	-0.5	0.1	-0.1
Reaction time num false alarms AUC	0.0	0.1	0.3	-0.1	0.2	0.1	0.5	-0.0
Reaction time trials correct on left	0.4	0.7	1.3	-0.6	0.6	0.8	1.2	-1.0
Reaction time trials on left	0.5	0.9	1.6	-0.7	0.7	0.9	1.3	-1.1
Reaction time mean	0.1	0.1	0.2	-0.2	-0.1	0.3	-0.5	-0.3
Reaction time mean AUC	0.1	0.1	0.5	-0.1	-0.1	0.2	-0.7	-0.2
Median of all reaction times	0.2	0.3	0.8	0.5	-0.6	-0.4	-0.9	-0.1
Reaction time omissions	1.5	2.1	3.7	-1.9	1.6	1.8	0.9	-0.6
Reaction time false alarm rate	0.1	0.2	0.3	0.5	-0.4	-0.5	-0.2	0.4
Reaction time premature initiation rate	2.2	3.0	5.1	-1.8	1.8	1.8	2.3	-0.0
Reaction time premature initiations	3.1	5.5	9.2	-2.3	2.4	2.5	3.0	-0.8
Std. dev. reaction times	0.5	0.8	1.6	-1.2	0.9	1.3	0.2	-0.4
Reaction time trials completed	0.5	0.9	1.6	-0.7	0.7	0.9	1.3	-1.1
Reaction time trials AUC	0.3	0.6	1.2	-0.5	0.5	0.7	1.1	-0.9
Run reversals in cocaine runway, females	0.8	0.8	3.1	-0.6	0.4	-0.0	-0.3	1.8
Run reversals in cocaine runway, males	1.0	1.0	3.6	0.6	-0.5	0.0	1.0	-1.9
Latency to leave start box in cocaine runway	0.6	0.7	2.1	0.0	-0.1	-0.5	-1.5	1.1
Latency to leave start box in cocaine runway, F	0.4	0.4	1.2	-0.0	-0.0	-0.4	-1.1	0.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	-0.4	0.2	0.2	-0.5	0.3
Std. dev. time between licks in bursts	0.2	0.2	0.8	0.1	-0.2	-0.1	0.9	-0.5
Total sessions with >9 infusions	0.5	0.6	1.5	-0.2	0.2	-0.2	-1.1	1.2
Short access day 1 total inactive lever presses	1.6	2.1	3.2	1.7	-1.6	-1.8	-1.3	0.4
Short access day 10 total inactive lever presses	0.1	0.3	0.6	0.8	-0.7	-0.7	-0.3	0.2
Short access day 1 total infusions	1.7	2.2	3.2	1.3	-1.2	-1.7	-1.8	1.3
Short access day 10 total infusions	2.0	2.5	6.1	0.3	-0.2	-1.1	-2.5	2.3
Short access total infusions	1.0	1.3	2.6	0.5	-0.3	-1.0	-1.6	1.6
Short access day 1 locomotion	1.2	1.5	2.3	1.3	-1.0	-1.4	-1.5	0.9
Short access day 10 total locomotion	0.9	1.6	3.1	1.2	-0.9	-1.3	-1.8	1.1
Short access total locomotion	1.5	1.8	3.3	1.3	-1.0	-1.4	-1.8	1.0
One hour access (0.3 mA shock)	4.8	5.5	8.2	2.9	-2.8	-2.7	-2.0	0.3
Compulsive drug intake	1.8	2.2	4.7	-1.4	1.3	1.5	2.2	-0.6
One hour access (shock baseline)	4.4	6.7	9.1	3.0	-2.9	-2.9	-2.7	0.2
Social response proportion	0.5	0.5	0.9	-1.0	0.8	0.9	0.6	0.1
Social responses	0.3	0.4	0.7	-0.5	0.6	0.7	0.8	-0.4
Social time	0.4	0.6	1.2	-0.6	0.6	0.7	1.1	-0.6
Soleus weight	3.3	9.8	15.3	3.9	-3.9	-3.6	-2.4	-0.1
Bone: stiffness	1.6	2.7	4.9	-2.2	2.1	1.7	0.2	1.0
Tibialis anterior weight	8.9	30.0	42.9	-6.4	6.4	6.6	4.6	-2.3
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.5	-0.4	0.3	0.1	-0.4	0.7
Time to tail flick, vehicle, after self-admin	0.7	1.0	4.0	-0.5	0.5	0.1	-0.6	2.0
Time to tail flick, test, before self-admin	3.0	3.1	4.2	1.7	-1.4	-1.9	-1.7	2.0
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.1	0.0	0.3	-0.2	-0.4
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.3	-0.5	0.5	0.3	-0.0	1.1
Delta time to tail flick, test, before/after SA	3.8	3.9	7.8	-1.4	1.2	2.1	2.0	-2.8
Tibia length	1.2	3.2	4.8	-1.9	1.9	2.2	0.8	-1.8
Ambulatory time before self-admin	0.3	0.4	0.6	-0.8	0.7	0.6	-0.8	0.3
Ambulatory time after self-admin	0.6	0.6	2.4	0.3	-0.5	-0.5	-1.6	0.6
Bone: tissue strength	0.0	0.0	0.2	-0.1	0.1	-0.0	-0.2	0.4
Total heroin consumption	4.0	4.7	7.7	-2.6	2.8	2.5	1.7	-0.3
Bone: trabecular number	0.8	1.3	2.4	-1.3	1.3	0.7	-0.6	1.6
Bone: trabecular spacing	0.3	0.5	0.9	0.9	-0.8	-0.8	0.1	-0.3
Bone: trabecular thickness	0.6	0.8	1.5	0.4	-0.5	-0.8	-1.2	1.2
Bone: trabecular tissue density	2.9	4.3	7.5	2.7	-2.6	-2.2	-1.3	-1.0
Water consumed over 24 hours	0.9	1.2	1.6	-1.2	1.3	1.2	1.3	-0.1
Number of responses in last shaping day	0.1	0.1	0.2	0.0	-0.1	-0.0	0.4	-0.4