Gstp3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	isoform ratio	XM_039108270.2	0.24	0.13	4.3e-12	0.09	0.09	0.09	0.09	1.1e-09	1.2e-10	1.7e-10	1.0e-09
2	Liver	isoform ratio	NM_001398780.1	0.3	0.15	2.3e-09	0.06	0.08	0.09	0.06	1.6e-07	1.3e-09	1.1e-09	2.3e-07
3	Liver	alternative TSS	XM_039108270.2	0.25	0.13	6.7e-14	0.1	0.1	0.11	0.09	1.0e-10	5.2e-11	3.5e-12	2.1e-10
4	Liver	alternative TSS	NM_001134508.2	0.25	0.14	1.3e-11	0.08	0.08	0.09	0.07	3.8e-09	1.3e-09	1.6e-10	1.1e-08
5	Liver	gene expression	Gstp3	0.1	0.09	7.1e-04	0.03	0.03	0.02	0.02	7.1e-04	7.2e-04	2.9e-03	4.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.7	1.3	3.8	0.8	0.4	-1.1	0.8	2.0
Area under the delay curve	0.3	0.4	1.9	-0.1	-0.3	-0.0	0.0	1.4
BMI with tail	1.8	6.2	15.2	2.2	0.6	-2.5	2.1	3.9
BMI without tail	0.7	3.9	5.2	2.2	1.1	-2.3	2.0	2.1
Body weight	2.4	10.6	14.8	3.8	3.0	-3.6	3.2	2.5
Weight adjusted by age	0.5	1.4	2.6	1.3	1.6	-1.2	1.2	0.1
Bone surface	2.2	4.4	6.9	2.1	1.5	-2.2	1.9	2.6
Bone volume	0.7	1.5	3.8	0.9	0.6	-1.2	0.9	2.0
Breakpoint value in progressive ratio session	1.3	2.4	3.3	1.8	1.2	-1.8	1.7	0.9
Number of licking bursts	0.0	0.0	0.0	-0.0	0.2	0.1	-0.1	0.1
Context. condit. distance diff. score	0.6	0.7	1.3	-1.1	-0.9	0.8	-0.8	-0.0
Locomotion velocity, session 1	0.0	0.0	0.0	0.0	0.1	-0.2	0.1	0.1
Locomotion distance, session 1	0.7	0.9	2.7	0.7	0.2	-0.9	0.7	1.6
Locomotion velocity, session 2	1.6	1.9	3.0	1.7	1.4	-1.5	1.4	0.6
Locomotion distance, session 2	0.9	1.3	1.7	1.2	0.7	-1.3	1.1	1.2
Locomotion velocity, session 3	0.5	0.6	2.4	-0.0	-0.6	-0.5	0.3	1.6
Locomotion distance, session 3	0.1	0.1	0.3	0.0	-0.2	-0.4	0.3	0.6
Stereotopy head waving bouts, day 3	0.5	0.6	1.4	-0.5	-1.0	0.3	-0.4	1.2
Stereotopy head waving duration, day 3	0.8	1.0	1.6	-1.1	-1.3	1.0	-1.0	0.5
Locomotion velocity, session 7	0.4	0.4	1.6	0.1	-0.5	-0.5	0.4	1.3
Locomotion distance, session 7	0.4	0.5	0.6	0.7	0.4	-0.8	0.7	0.7
Stereotopy head waving bouts, day 7	0.5	0.6	1.4	-0.5	-0.8	0.5	-0.6	1.2
Stereotopy head waving duration, day 7	0.5	0.6	2.3	0.6	0.2	-0.5	0.3	1.5
Locomotion velocity, session 8	1.2	1.4	2.4	1.5	1.5	-1.1	1.0	0.5
Locomotion distance, session 8	0.1	0.1	0.3	-0.5	-0.4	0.2	-0.2	0.4
Degree of sensitization distance	0.3	0.3	0.6	0.6	0.3	-0.6	0.5	0.8
Degree of sensitization stereotypy	0.2	0.2	0.8	0.3	0.2	-0.1	-0.0	0.9
Conditioned locomotion	1.9	2.2	4.0	1.7	2.0	-1.2	1.3	-1.0
Cocaine response after cond. corrected	0.1	0.1	0.4	-0.3	-0.6	0.2	-0.2	0.2
Cocaine response after cond. not corrected	0.1	0.2	0.5	-0.4	-0.7	0.3	-0.3	0.5
Cocaine response before conditioning	0.0	0.0	0.1	0.1	0.2	0.1	-0.1	0.2
Saline control response	1.9	2.6	4.3	2.1	2.1	-1.5	1.4	0.6
Bone: connectivity density	2.4	3.8	5.4	1.9	1.5	-2.2	1.8	2.3
Bone: cortical apparent density	0.3	0.4	0.6	0.7	0.8	-0.7	0.6	-0.4
Bone: cortical area	0.3	0.5	1.4	0.8	1.2	-0.2	0.2	-0.6
Bone: cortical porosity	0.1	0.1	0.3	0.1	-0.1	0.3	-0.3	0.5
Bone: cortical porosity	0.1	0.1	0.3	0.6	0.5	-0.1	0.1	0.4
Bone: cortical thickness	3.0	5.0	10.9	2.7	3.3	-1.6	1.7	-1.1
Bone: cortical thickness	1.5	1.9	4.0	1.6	2.0	-1.1	1.1	-0.7
Bone: cortical tissue density	0.4	0.6	0.9	0.9	1.0	-0.8	0.8	-0.3
Condit. Reinf. active minus inactive responses	0.2	0.3	0.8	0.3	0.0	-0.5	0.4	0.9
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	-0.1	-0.3	-0.2	0.1	0.6
Condit. Reinf. active responses	0.0	0.0	0.1	0.0	-0.1	-0.2	0.2	0.3
Condit. Reinf. inactive responses	0.1	0.1	0.1	-0.3	-0.3	0.3	-0.3	-0.3
Incentive salience index mean	0.2	0.2	0.5	0.4	0.2	-0.5	0.5	0.7
Condit. Reinf. lever presses	0.0	0.1	0.2	0.2	0.4	-0.1	0.1	-0.2
Condit. Reinf. active minus inactive responses	0.5	0.7	1.6	-0.7	-1.3	0.2	-0.3	1.2
Condit. Reinf. active-inactive response ratio	1.0	1.5	3.2	-1.5	-1.8	1.0	-1.0	0.5
Condit. Reinf. active responses	0.5	0.7	2.7	-0.1	-0.8	-0.3	0.1	1.7
Condit. Reinf. inactive responses	0.7	1.1	1.9	1.1	0.6	-1.1	0.9	1.4
Condit. Reinf. lever presses	0.6	0.8	2.0	0.9	0.4	-0.9	0.7	1.4
Condit. Reinf. lever reinforcers received	0.6	0.8	3.2	0.1	-0.6	-0.6	0.4	1.8
Conditioned reinforcement - actives	0.1	0.4	0.7	-0.4	-0.7	0.7	-0.6	-0.8
Conditioned reinforcement - inactives	1.2	3.4	5.6	-2.2	-2.4	1.8	-1.8	-0.5
Conditioned locomotion	5.9	8.8	13.6	-3.7	-3.0	3.1	-2.8	-1.8
Patch foraging indifference point 0 sec	0.2	0.6	0.9	-0.8	-1.0	1.0	-0.9	0.0
Patch foraging indifference point AUC	0.4	0.9	1.3	1.1	1.1	-1.0	1.1	0.1
Delay disc. indifference point, 0s delay	0.8	0.9	3.6	-0.3	-0.9	0.2	-0.2	1.9
Delay disc. indifference point, 16s delay	0.8	1.1	1.7	-1.3	-1.0	1.3	-1.1	0.3
Delay disc. indifference point, 2s delay	0.3	0.3	0.6	-0.7	-0.5	0.5	-0.4	0.8
Delay disc. indifference point, 24s delay	0.0	0.1	0.2	0.2	-0.2	0.2	-0.2	-0.4
Delay disc. indifference point, 4s delay	0.4	0.4	1.7	0.2	0.3	-0.4	0.5	1.3
Delay disc. indifference point, 8s delay	0.1	0.2	0.9	0.1	-0.4	0.1	-0.1	0.9
Indifference point function ln k	1.5	4.7	6.3	-2.5	-2.2	2.3	-2.2	-1.4
Indifference point function log k	1.5	4.7	6.3	-2.5	-2.2	2.3	-2.2	-1.4
Patch foraging total patch changes 0 sec	0.1	0.3	0.4	-0.4	-0.5	0.7	-0.6	-0.4
Patch foraging total patch changes 12 sec	1.9	2.5	3.6	1.9	1.6	-1.7	1.7	0.9
Patch foraging total patch changes 18 sec	0.1	0.3	0.5	0.5	0.3	-0.5	0.5	0.7
Patch foraging total patch changes 24 sec	0.3	1.0	1.5	1.0	1.0	-1.2	1.2	-0.1
Patch foraging total patch changes 6 sec	0.6	1.0	1.8	1.0	0.4	-1.0	1.0	1.3
Patch foraging time to switch 0 sec	0.5	2.0	4.5	1.3	1.1	-1.3	1.0	2.1
Patch foraging water rate 0 sec	1.5	5.7	8.9	-2.4	-1.8	2.4	-2.1	-3.0
Patch foraging water rate 12 sec	1.9	7.6	9.7	-3.0	-2.3	2.8	-2.4	-3.1
Patch foraging water rate 18 sec	0.8	1.7	2.3	-1.4	-0.9	1.5	-1.4	-1.4
Patch foraging water rate 24 sec	2.1	3.1	4.8	-1.6	-1.2	1.9	-1.6	-2.2
Patch foraging water rate 6 sec	1.5	2.1	5.8	-1.3	-0.6	1.3	-1.1	-2.4
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.9	-0.0	-0.3	0.2	-0.2	1.4
Distance traveled before self-admin	0.1	0.2	0.4	0.2	0.0	-0.5	0.4	0.6
Distance traveled after self-admin	0.0	0.0	0.1	0.1	0.2	-0.1	-0.1	-0.4
Extensor digitorum longus weight	5.1	20.2	32.3	5.7	5.3	-4.5	4.3	1.3
Bone: elastic displacement	0.5	0.6	2.3	0.0	0.4	0.5	-0.3	-1.5
Bone: elastic work	1.4	1.8	3.7	1.7	1.9	-1.0	1.0	-0.5
Bone: endosteal estimation	1.0	2.4	4.3	-1.8	-2.1	1.4	-1.4	1.0
Bone: endosteal perimeter	2.1	5.1	9.7	-2.5	-3.1	1.9	-1.9	1.4
Epididymis fat weight	2.6	13.0	18.4	-4.3	-3.6	4.1	-3.8	-1.7
Delta time in closed arm before/after self-admin	1.0	1.0	1.6	1.3	1.1	-1.0	1.0	0.4
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.2	0.3
Diff in mean of infusions in LGA sessions	0.4	0.7	1.4	1.0	1.2	-0.7	0.8	-0.2
Delay discount exponential model param	0.2	0.3	1.4	-0.0	0.1	0.2	-0.2	-1.2
Extinction: sum of active levers before priming	1.1	1.7	2.5	1.6	0.9	-1.5	1.3	1.0
Active lever presses in extinction session 6	1.3	1.3	1.7	1.3	1.2	-1.3	1.3	0.3
Bone: final force	1.0	1.6	2.2	1.5	1.5	-1.3	1.2	0.7
Bone: final moment	1.0	1.6	2.2	1.5	1.4	-1.3	1.2	0.6
Food consumed during 24 hour testing period	0.3	0.6	0.9	-0.7	-0.2	0.9	-0.8	-1.0
Glucose	1.3	2.1	3.7	-1.8	-1.9	1.0	-1.2	1.1
Heart weight	0.5	0.7	1.6	-0.7	-0.9	0.5	-0.6	1.3
Delay discount hyperbolic model param	0.3	0.3	1.5	0.0	0.1	0.2	-0.2	-1.2
Intermittent access intake day 1-15 change	0.8	4.2	6.1	-2.4	-1.5	2.5	-2.3	-1.4
Intermittent access intake escalation	0.7	3.7	5.5	-2.2	-1.3	2.3	-2.2	-1.5
Intermittent access intake escalation 2	1.6	2.7	4.0	-2.0	-1.2	2.0	-1.9	-1.0
Intermitt. access day 1 inactive lever presses	0.0	0.3	1.0	-0.1	-1.0	0.5	-0.5	0.2
Intermitt. access day 15 inactive lever presses	0.5	2.7	3.7	-1.7	-1.9	1.9	-1.9	0.2
Intermitt. access escalation Index	0.8	2.6	3.9	-1.9	-0.9	2.0	-1.7	-1.3
Intermittent access day 1 total infusions	1.0	3.0	6.8	-1.7	-2.6	1.1	-1.3	1.5
Intermittent access day 15 total infusions	3.0	7.5	10.5	-3.2	-3.2	2.9	-2.8	-0.4
Intermittent access terminal intake (last 3 days)	3.2	5.7	8.5	-2.9	-2.9	2.4	-2.4	0.4
Intermittent access total infusions	2.8	3.3	5.9	-2.1	-2.4	1.7	-1.6	0.8
Intermittent access day 1 locomotion	0.9	1.6	4.4	-1.2	-2.1	0.6	-0.7	1.2
Intermittent access day 15 total locomotion	1.4	5.3	8.9	-3.0	-2.5	2.4	-2.3	-0.2
Intermittent access total locomotion	6.1	7.3	11.6	-3.4	-3.2	2.8	-2.6	0.3
Intermittent access standard deviation	0.2	1.0	1.7	-1.3	-0.8	1.1	-1.1	-0.3
Left kidney weight	0.5	4.4	6.2	-2.5	-2.3	2.4	-2.2	-0.5
Right kidney weight	0.5	3.4	4.9	-2.0	-1.5	2.2	-2.0	-1.3
Cocaine induced anxiety	0.0	0.0	0.0	-0.1	0.0	-0.0	-0.1	0.0
Post-drug Anxiety	0.3	0.3	0.5	0.7	0.6	-0.6	0.5	0.1
Baseline Anxiety	0.2	0.4	0.7	0.9	0.7	-0.7	0.6	-0.1
Tail length	0.5	2.4	4.1	1.9	2.0	-1.3	1.3	-1.0
Length with tail	1.8	7.9	13.7	3.4	3.7	-2.7	2.5	-0.2
Length without tail	1.0	5.1	9.1	2.8	3.0	-2.1	2.0	0.2
Times rat made contact with spout	0.4	0.4	0.9	0.8	0.5	-0.5	0.4	0.9
Lifetime Intake	1.8	2.3	5.1	-1.6	-2.3	1.2	-1.2	0.8
Liver weight, left	0.5	0.9	1.8	-0.8	-0.4	1.0	-0.9	-1.3
Liver weight, right	1.1	1.8	2.2	-1.5	-1.1	1.5	-1.3	-1.4
Locomotor activity	0.7	1.1	2.2	-1.0	-0.6	1.1	-1.0	-1.5
Locomotor testing distance	0.6	1.4	2.2	-1.2	-0.9	1.2	-1.1	-1.5
Locomotor testing rearing	0.2	0.6	1.1	-1.1	-1.0	0.7	-0.7	-0.1
Locomotion in novel chamber	4.8	6.5	10.0	-3.2	-2.7	2.6	-2.6	-1.1
Locomotion in novel chamber post-restriction	1.4	4.2	5.9	-2.4	-1.9	2.4	-2.2	-0.8
Fecal boli incidents, locomotor time 1	0.1	0.3	0.7	-0.2	-0.2	0.8	-0.7	0.3
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.3	0.3	-0.5	0.4	0.4
Time >=10cm from walls, locomotor time 1	1.4	1.7	3.2	-1.4	-1.8	0.9	-1.1	1.1
Bouts of movement, locomotor time 1	0.9	1.1	3.0	1.0	1.7	-0.7	0.9	-0.2
Total resting periods, locomotor time 1	0.5	0.5	1.7	0.6	1.3	-0.4	0.5	-0.4
Rest time, locomotor task time 1	1.3	2.1	2.6	-1.6	-1.1	1.6	-1.4	-1.5
Distance moved, locomotor task time 1	0.1	0.4	1.5	0.2	-0.2	-0.4	0.2	1.2
Vertical activity count, locomotor time 1	0.1	0.7	1.2	-1.1	-1.1	0.8	-0.8	0.2
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.2	-0.4	-0.2	0.4	-0.4	-0.2
Bouts of movement, locomotor time 2	0.1	0.3	0.7	0.8	0.1	-0.3	0.3	0.8
Total resting periods, locomotor time 2	0.1	0.2	0.8	0.4	-0.4	0.1	-0.0	0.9
Rest time, locomotor task time 2	1.6	2.7	4.9	-1.8	-2.2	1.6	-1.6	0.2
Distance moved, locomotor task time 2	1.0	1.3	2.7	1.1	1.6	-1.0	1.0	-0.7
Vertical activity count, locomotor time 2	0.4	0.8	2.8	0.4	1.1	-0.1	0.2	-1.7
Light reinforcement 1	0.2	0.8	1.3	-1.1	-0.7	1.0	-0.9	-0.8
Light reinforcement 2	1.0	2.3	3.5	-1.9	-1.5	1.5	-1.4	-1.1
Bone: marrow area	1.0	2.5	4.5	-1.8	-2.1	1.4	-1.4	1.0
Bone: maximum diameter	0.2	0.4	0.7	-0.5	-0.2	0.9	-0.8	-0.5
Bone: maximum force	1.2	2.5	5.1	1.6	0.9	-1.5	1.2	2.3
Bone: maximum moment	1.2	2.3	4.6	1.6	0.9	-1.5	1.2	2.1
Mean time between licks in bursts	0.1	0.6	0.8	0.9	0.8	-0.9	0.9	0.3
Mean num. licks in bursts	0.0	0.1	0.3	0.3	-0.2	-0.2	0.1	0.5
Cd content in liver	1.5	1.6	2.6	-1.6	-1.4	1.4	-1.3	-0.3
Co content in liver	0.5	0.6	2.7	-0.5	-0.1	0.4	-0.2	-1.6
Cu content in liver	0.0	0.0	0.1	-0.2	-0.3	-0.2	0.2	-0.0
Fe content in liver	0.2	0.3	0.5	0.5	0.3	-0.7	0.7	0.1
K content in liver	0.5	0.5	0.7	0.7	0.5	-0.8	0.7	0.8
Mg content in liver	0.3	0.3	0.6	-0.7	-0.8	0.5	-0.5	0.4
Mn content in liver	1.8	2.0	2.9	1.7	1.4	-1.6	1.5	0.7
Na content in liver	0.2	0.3	1.1	-0.1	0.4	0.2	-0.1	-1.0
Rb content in liver	1.0	1.1	2.4	-1.2	-1.5	0.8	-0.8	0.7
Se content in liver	0.2	0.3	0.4	-0.5	-0.6	0.3	-0.4	0.6
Sr content in liver	1.6	1.4	2.5	1.4	1.6	-1.0	1.0	-0.5
Zn content in liver	0.3	0.3	0.6	0.7	0.8	-0.5	0.5	-0.4
Bone: minimum diameter	1.1	2.1	3.1	-1.2	-1.8	1.2	-1.2	1.7
Time in familiar zone, hab. session 1	0.2	0.3	0.6	-0.6	-0.8	0.2	-0.3	0.4
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.1	0.3	0.3	-0.3	-0.4
Total zone transitions, hab. session 1	0.3	0.4	0.6	0.8	0.8	-0.5	0.4	0.4
Total locomotion distance, hab. session 1	0.4	0.6	0.8	-0.9	-0.8	0.8	-0.8	-0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.4	-0.1
Time in familiar zone, hab. session 2	0.6	0.6	1.5	0.8	1.2	-0.6	0.6	-0.5
Time in novel zone, hab. session 2	0.4	0.4	1.1	-0.3	-0.8	0.2	-0.3	1.1
Total zone transitions, hab. session 2	1.8	2.3	6.9	1.2	0.3	-1.4	1.1	2.6
Total locomotion distance, hab. session 2	0.4	0.5	1.9	-0.1	-0.6	-0.2	0.0	1.4
Locomotion velocity, hab. session 2	0.4	0.5	1.6	-0.4	-0.9	0.1	-0.2	1.3
Novel to familiar place preference ratio	0.1	0.1	0.5	0.2	-0.0	-0.0	-0.1	0.7
Novelty place preference	0.1	0.2	0.4	-0.2	-0.3	0.3	-0.4	0.6
Time in novel zone, NPP test	0.1	0.2	0.4	-0.1	-0.3	0.3	-0.4	0.6
Total zone transitions, NPP test	1.1	1.7	2.2	1.2	1.0	-1.5	1.3	1.5
Total locomotion distance, NPP test	0.2	0.2	0.6	-0.1	-0.3	-0.5	0.4	0.8
Locomotion velocity, NPP test	0.1	0.2	0.4	-0.1	-0.3	-0.4	0.4	0.6
Intraocular pressure	0.6	0.9	1.5	-0.8	-0.6	1.2	-1.0	-1.1
Delta distance traveled before/after self-admin	0.2	0.2	0.8	0.1	0.5	0.2	-0.3	-0.9
Delta ambulatory time before/after self-admin	0.1	0.2	0.7	0.2	0.4	0.1	-0.1	-0.8
Parametrial fat weight	2.1	5.0	8.0	-2.8	-2.5	2.4	-2.2	-0.0
Pavlov. Cond. lever latency	0.4	0.5	0.8	-0.7	-0.9	0.8	-0.8	-0.4
Pavlov. Cond. magazine entry latency	0.2	0.2	0.9	-0.2	-0.2	0.2	-0.3	0.9
Pavlov. Cond. change in total contacts	0.2	0.3	0.4	-0.6	-0.5	0.5	-0.5	0.4
Pavlov. Cond. index score	0.0	0.0	0.1	-0.2	0.3	0.2	-0.1	-0.0
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.0	0.3	-0.0	0.0	0.2
Pavlov. Cond. lever contacts	0.2	0.2	0.3	0.3	0.6	-0.5	0.5	0.3
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.3	-0.2	-0.5	0.5	0.3
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.9	-0.4	-0.2	0.3	-0.2	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.1	0.3	0.1	-0.1	0.0
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.3	0.3	0.5	-0.4	-0.4
Pavlov. Cond. lever latency	0.0	0.1	0.1	-0.0	-0.3	-0.3	0.2	0.3
Pavlov. Cond. magazine entry latency	2.2	3.1	4.2	2.0	1.5	-1.7	1.5	1.9
Pavlov. Cond. change in total contacts	0.1	0.2	0.9	0.3	0.1	-0.3	0.2	0.9
Pavlov. Cond. index score	0.4	0.6	0.9	0.9	0.8	-0.7	0.5	1.0
Pavlov. Cond. latency score	0.3	0.4	0.6	0.8	0.7	-0.5	0.4	0.8
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.1	0.4	0.2	-0.2	-0.2
Pavlov. Cond. magazine entry number	3.0	3.9	5.3	-2.3	-1.6	2.0	-1.8	-2.1
Pavlov. Cond. intertrial magazine entries	0.6	1.4	2.3	-1.5	-1.2	1.2	-1.0	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.6	1.0	1.3	1.2	0.9	-0.9	0.8	1.1
Pavlov. Cond. response bias	0.5	0.6	0.9	0.9	0.8	-0.7	0.6	1.0
Time in closed arm before self-admin	0.4	0.7	1.3	-1.1	-1.1	0.7	-0.6	0.5
Time in closed arm after self-admin	0.0	0.1	0.1	-0.2	-0.3	0.2	-0.2	0.2
Time in open arm before self-admin	0.8	1.0	2.0	1.0	1.4	-0.7	0.7	-0.8
Time in open arm after self-admin	0.7	0.7	1.2	0.9	1.1	-1.0	0.9	0.0
Bone: periosteal estimation	0.1	0.3	0.5	-0.6	-0.5	0.7	-0.7	0.2
Bone: periosteal perimeter	0.2	0.4	0.9	-0.5	-0.7	0.5	-0.5	0.9
Bone: post-yield work	2.0	3.4	13.9	-0.4	-1.7	-0.4	0.0	3.7
Progressive ratio test 1 active lever presses	0.2	0.3	1.6	-0.1	-1.2	0.1	-0.1	0.4
Progressive ratio test 1 breakpoint	0.2	0.3	1.3	-0.1	-1.2	0.0	-0.1	0.4
Progressive ratio test 1 inactive lever presses	0.1	0.4	1.6	-0.1	-1.3	0.1	-0.2	0.5
Progressive ratio test 2 active lever presses	1.6	2.3	5.2	-1.6	-2.3	1.3	-1.3	0.2
Progressive ratio test 2 breakpoint	1.6	2.1	4.7	-1.6	-2.2	1.3	-1.3	0.1
Progressive ratio test 2 inactive lever presses	3.0	9.7	16.1	-3.5	-4.0	3.2	-3.1	-0.3
Incentive Sensitization - Responses	0.1	0.2	0.7	-0.0	-0.2	-0.2	0.0	0.8
Incentive Sensitization - Breakpoint	0.1	0.1	0.5	-0.3	-0.3	-0.0	-0.1	0.7
Sum of active levers in priming session hrs 5-6	1.2	1.1	5.0	0.1	0.5	0.4	-0.3	-2.2
Progressive ratio	0.6	1.9	5.3	1.0	0.3	-1.4	1.1	2.3
Food seeking constrained by brief footshock	0.1	0.1	0.1	0.4	0.2	-0.1	0.1	0.3
Seeking ratio, punishment vs. effort	0.7	1.5	2.8	-1.0	-0.4	1.5	-1.2	-1.7
Retroperitoneal fat weight	6.4	28.6	43.2	-6.6	-5.5	5.8	-5.4	-2.4
Reaction time number correct	0.2	0.6	1.1	0.9	1.0	-0.7	0.6	-0.5
Reaction time mean minus median	0.4	2.3	3.5	1.9	1.0	-1.5	1.3	1.7
Reaction time mean minus median AUC	0.3	2.0	3.3	1.8	1.3	-1.5	1.4	0.9
Reaction time num false alarms	0.2	0.4	1.5	0.2	0.6	0.0	0.1	-1.2
Reaction time num false alarms AUC	0.3	0.8	1.5	0.9	1.2	-0.6	0.7	-0.9
Reaction time trials correct on left	0.2	0.6	1.1	0.9	1.0	-0.7	0.6	-0.5
Reaction time trials on left	0.2	0.7	1.3	1.0	1.2	-0.7	0.7	-0.5
Reaction time mean	0.0	0.1	0.3	-0.1	-0.3	0.0	-0.2	0.5
Reaction time mean AUC	0.0	0.1	0.3	-0.2	-0.4	0.1	-0.2	0.6
Median of all reaction times	0.2	0.3	0.4	-0.6	-0.6	0.4	-0.5	0.4
Reaction time omissions	1.7	2.7	4.1	2.0	1.7	-1.8	1.6	0.9
Reaction time false alarm rate	0.1	0.2	0.5	0.3	0.5	-0.0	0.1	-0.7
Reaction time premature initiation rate	2.7	4.2	6.2	2.3	1.9	-2.5	2.3	0.6
Reaction time premature initiations	2.0	5.9	8.2	2.9	2.5	-2.8	2.7	0.2
Std. dev. reaction times	0.2	0.6	1.0	1.0	0.4	-0.8	0.7	1.0
Reaction time trials completed	0.2	0.7	1.3	1.0	1.2	-0.7	0.7	-0.5
Reaction time trials AUC	0.2	0.6	1.1	0.9	1.0	-0.6	0.6	-0.4
Run reversals in cocaine runway, females	0.8	0.9	1.6	0.9	0.5	-1.1	0.8	1.3
Run reversals in cocaine runway, males	0.3	0.3	1.1	0.3	0.6	0.2	-0.2	-1.1
Latency to leave start box in cocaine runway	0.2	0.3	0.8	-0.5	-0.6	0.1	-0.2	0.9
Latency to leave start box in cocaine runway, F	0.1	0.2	0.8	-0.3	0.1	0.1	-0.2	0.9
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.0	-0.4	-0.3	0.2	0.0
Std. dev. time between licks in bursts	0.5	1.0	1.9	0.9	1.4	-0.8	0.9	-1.0
Total sessions with >9 infusions	0.3	0.3	0.7	0.3	-0.7	-0.5	0.4	0.8
Short access day 1 total inactive lever presses	1.3	2.6	3.9	-1.6	-2.0	1.8	-1.8	-0.3
Short access day 10 total inactive lever presses	0.0	0.1	0.2	-0.1	-0.5	0.4	-0.4	0.2
Short access day 1 total infusions	1.0	1.9	4.7	-1.3	-2.2	1.3	-1.3	0.2
Short access day 10 total infusions	0.7	1.1	3.4	-0.4	-1.4	-0.0	-0.1	1.8
Short access total infusions	0.5	0.7	1.8	-0.2	-1.4	-0.0	-0.1	1.2
Short access day 1 locomotion	0.6	0.9	2.2	-1.1	-1.5	0.8	-0.8	0.2
Short access day 10 total locomotion	0.1	0.5	1.2	-0.9	-1.1	0.3	-0.3	0.6
Short access total locomotion	0.6	0.9	2.6	-1.1	-1.6	0.6	-0.6	0.5
One hour access (0.3 mA shock)	4.6	5.5	10.7	-2.7	-3.3	2.2	-2.1	-0.3
Compulsive drug intake	1.4	2.0	4.5	2.1	1.2	-1.5	1.4	-0.3
One hour access (shock baseline)	3.1	8.0	12.8	-3.5	-3.6	2.9	-2.7	-0.4
Social response proportion	0.5	0.7	1.0	0.9	0.6	-0.9	0.7	1.0
Social responses	0.7	0.9	1.3	1.0	1.0	-1.1	1.1	0.3
Social time	0.8	1.2	1.9	1.1	0.9	-1.4	1.3	0.7
Soleus weight	3.5	10.4	13.8	-3.7	-2.9	3.6	-3.2	-2.5
Bone: stiffness	0.7	1.3	4.3	1.0	0.5	-0.8	0.6	2.1
Tibialis anterior weight	5.7	19.6	32.5	5.6	5.7	-4.2	4.1	-0.3
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.0	0.3	1.0	-0.3	0.3	1.0
Time to tail flick, vehicle, after self-admin	1.1	2.3	5.0	1.4	0.3	-1.6	1.4	2.2
Time to tail flick, test, before self-admin	0.7	0.8	2.4	-0.8	-0.8	0.3	-0.4	1.6
Time to tail flick, test, after self-admin	0.3	0.3	1.4	0.0	1.2	0.3	-0.2	-0.2
Delta time to tail flick, vehicle, before/after SA	1.2	1.3	2.4	1.1	-0.2	-1.3	1.1	1.5
Delta time to tail flick, test, before/after SA	1.5	1.9	4.5	0.9	2.0	-0.1	0.4	-2.1
Tibia length	0.2	0.6	2.0	0.5	1.0	0.1	0.0	-1.4
Ambulatory time before self-admin	0.1	0.2	0.6	0.1	-0.1	-0.4	0.3	0.8
Ambulatory time after self-admin	0.4	0.6	1.0	-1.0	-1.0	0.7	-0.8	0.2
Bone: tissue strength	0.2	0.2	0.3	-0.3	-0.5	0.4	-0.4	0.5
Total heroin consumption	3.0	3.5	6.0	2.4	1.6	-2.1	1.9	1.0
Bone: trabecular number	0.8	1.4	3.6	0.8	0.4	-1.3	1.0	1.9
Bone: trabecular spacing	0.2	0.4	0.6	-0.6	-0.7	0.7	-0.5	-0.4
Bone: trabecular thickness	0.2	0.2	0.5	-0.5	-0.5	0.1	-0.3	0.7
Bone: trabecular tissue density	4.8	8.3	11.6	-3.2	-2.4	3.4	-3.0	-2.2
Water consumed over 24 hours	0.3	0.6	1.0	1.0	0.9	-0.6	0.5	0.8
Number of responses in last shaping day	0.1	0.2	0.3	0.4	-0.5	-0.5	0.4	0.3