Hub : Genes

Hey1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Hey1	0.22	0.12	1.6e-14	0.09	0.09	0.09	0.09	6.4e-10	5.9e-10	2.1e-10	4.3e-10
2	Adipose	gene expression	Hey1	0.04	0.03	1.6e-03	0	0	-0	-0	1.1e-01	1.7e-01	7.5e-01	4.5e-01
3	BLA	gene expression	Hey1	0.08	0.06	1.6e-03	0.02	0.03	0.01	0.03	4.5e-02	1.4e-02	8.9e-02	1.5e-02
4	Liver	gene expression	Hey1	0.03	0.03	6.4e-03	0	0.01	0.01	0	2.1e-01	1.8e-02	3.4e-02	7.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.9	1.6	2.0	1.2	-1.2	-1.2	1.4
Area under the delay curve	0.9	0.9	1.6	-1.0	0.5	0.9	-1.3
BMI with tail	3.7	12.1	16.4	-4.0	4.0	4.0	-0.4
BMI without tail	8.3	17.2	23.1	-4.8	4.6	4.8	-1.5
Body weight	1.6	6.5	9.5	-2.8	3.1	3.0	-0.0
Weight adjusted by age	0.1	0.1	0.1	0.3	0.2	-0.2	0.2
Bone surface	0.8	1.4	3.9	0.7	-0.8	-0.7	2.0
Bone volume	1.1	1.9	4.5	1.0	-1.1	-1.1	2.1
Breakpoint value in progressive ratio session	0.3	0.4	0.6	-0.7	0.8	0.6	-0.0
Number of licking bursts	0.1	0.1	0.1	-0.3	0.0	0.3	-0.3
Context. condit. distance diff. score	0.2	0.2	0.7	-0.3	0.3	0.3	-0.8
Locomotion velocity, session 1	0.3	0.4	0.6	-0.7	0.8	0.6	-0.3
Locomotion distance, session 1	0.4	0.5	0.7	-0.6	0.9	0.7	0.6
Locomotion velocity, session 2	1.4	1.7	2.3	-1.5	1.5	1.5	-0.1
Locomotion distance, session 2	0.8	1.1	2.4	-0.6	0.9	0.8	1.6
Locomotion velocity, session 3	0.1	0.2	0.4	0.3	-0.0	-0.5	-0.6
Locomotion distance, session 3	0.3	0.3	0.8	0.3	-0.2	-0.3	0.9
Stereotopy head waving bouts, day 3	0.1	0.2	0.2	0.4	-0.4	-0.5	0.3
Stereotopy head waving duration, day 3	0.4	0.4	0.7	-0.5	0.6	0.5	-0.8
Locomotion velocity, session 7	8.3	9.1	16.2	2.8	-2.4	-2.6	4.0
Locomotion distance, session 7	4.4	5.6	6.4	2.5	-2.4	-2.3	2.2
Stereotopy head waving bouts, day 7	0.6	0.7	1.0	-1.0	1.0	1.0	-0.1
Stereotopy head waving duration, day 7	1.2	1.4	1.7	-1.3	1.3	1.2	-0.9
Locomotion velocity, session 8	2.0	2.4	3.3	-1.8	1.7	1.8	-0.4
Locomotion distance, session 8	0.5	0.7	0.9	-0.9	0.9	1.0	0.3
Degree of sensitization distance	0.8	0.8	1.0	1.0	-1.0	-0.9	0.8
Degree of sensitization stereotypy	2.2	2.4	3.2	-1.8	1.7	1.7	-1.0
Conditioned locomotion	0.2	0.3	0.9	0.3	-0.2	-0.3	0.9
Cocaine response after cond. corrected	1.3	1.5	2.2	1.4	-1.5	-1.3	0.2
Cocaine response after cond. not corrected	3.2	3.5	4.7	2.2	-2.1	-2.1	0.5
Cocaine response before conditioning	0.7	0.8	1.3	1.0	-0.7	-1.1	0.8
Saline control response	0.6	0.8	2.5	0.5	-0.4	-0.6	1.6
Bone: connectivity density	1.1	1.7	2.0	1.3	-1.3	-1.2	1.4
Bone: cortical apparent density	0.2	0.3	0.4	-0.5	0.7	0.5	-0.4
Bone: cortical area	1.0	1.5	2.2	-1.5	1.3	1.5	-0.0
Bone: cortical porosity	0.1	0.1	0.1	-0.2	0.3	0.3	0.1
Bone: cortical porosity	0.0	0.0	0.0	-0.1	0.2	0.1	0.2
Bone: cortical thickness	0.7	1.2	1.6	-1.3	1.2	1.3	-0.2
Bone: cortical thickness	4.2	4.9	6.6	-2.6	2.4	2.4	-1.3
Bone: cortical tissue density	0.2	0.3	0.4	-0.5	0.6	0.5	-0.4
Condit. Reinf. active minus inactive responses	2.9	3.2	4.8	-1.5	1.9	1.4	2.2
Condit. Reinf. active-inactive response ratio	3.9	4.3	7.0	-1.7	2.2	1.6	2.6
Condit. Reinf. active responses	2.6	3.1	4.7	-1.5	1.9	1.4	2.2
Condit. Reinf. inactive responses	0.3	0.4	0.5	-0.7	0.7	0.7	-0.2
Incentive salience index mean	2.9	3.5	4.4	-1.7	2.0	1.7	2.1
Condit. Reinf. lever presses	1.6	2.2	2.9	-1.5	1.6	1.7	1.1
Condit. Reinf. active minus inactive responses	1.4	1.8	4.5	1.0	-0.9	-0.8	2.1
Condit. Reinf. active-inactive response ratio	0.7	0.7	2.8	0.1	0.0	0.1	1.7
Condit. Reinf. active responses	2.9	4.1	7.4	1.8	-1.7	-1.6	2.7
Condit. Reinf. inactive responses	1.2	1.5	1.7	1.2	-1.2	-1.2	1.3
Condit. Reinf. lever presses	0.8	1.0	1.7	1.0	-0.9	-0.8	1.3
Condit. Reinf. lever reinforcers received	2.7	3.8	6.6	1.8	-1.7	-1.6	2.6
Conditioned reinforcement - actives	2.4	2.4	3.1	1.8	-1.3	-1.6	1.5
Conditioned reinforcement - inactives	1.1	1.3	2.2	1.5	-0.8	-1.2	0.9
Conditioned locomotion	0.5	0.6	1.1	0.6	-1.1	-0.8	0.6
Patch foraging indifference point 0 sec	0.8	1.2	1.7	1.3	-1.2	-1.3	-0.1
Patch foraging indifference point AUC	0.1	0.1	0.2	0.4	0.1	-0.5	0.1
Delay disc. indifference point, 0s delay	0.1	0.1	0.5	-0.0	-0.2	0.1	-0.7
Delay disc. indifference point, 16s delay	0.5	0.6	0.8	-0.9	0.3	0.9	-0.7
Delay disc. indifference point, 2s delay	1.2	1.3	3.3	-0.9	1.8	1.0	0.6
Delay disc. indifference point, 24s delay	0.3	0.3	0.5	-0.1	-0.7	0.0	-0.7
Delay disc. indifference point, 4s delay	3.0	3.2	3.9	-2.0	1.6	1.8	-1.7
Delay disc. indifference point, 8s delay	0.5	0.5	1.9	0.1	-0.4	-0.1	-1.4
Indifference point function ln k	0.9	1.2	1.9	-1.1	0.6	1.2	-1.4
Indifference point function log k	0.9	1.2	1.9	-1.1	0.6	1.2	-1.4
Patch foraging total patch changes 0 sec	0.5	0.9	1.2	1.1	-1.0	-1.1	-0.5
Patch foraging total patch changes 12 sec	0.9	1.1	1.9	1.4	-0.7	-1.3	-0.7
Patch foraging total patch changes 18 sec	0.2	0.2	0.6	-0.1	0.8	-0.1	-0.4
Patch foraging total patch changes 24 sec	0.2	0.2	0.4	0.6	0.0	-0.6	-0.4
Patch foraging total patch changes 6 sec	0.1	0.2	0.4	0.5	-0.2	-0.6	-0.4
Patch foraging time to switch 0 sec	1.5	2.3	3.7	-1.5	1.9	1.5	1.2
Patch foraging water rate 0 sec	0.4	0.6	1.0	0.5	-1.0	-0.5	-0.9
Patch foraging water rate 12 sec	0.5	0.7	1.8	0.8	-1.3	-0.6	-0.0
Patch foraging water rate 18 sec	0.1	0.2	0.3	0.2	-0.5	-0.2	0.6
Patch foraging water rate 24 sec	0.1	0.2	0.8	0.0	-0.1	-0.0	-0.9
Patch foraging water rate 6 sec	0.5	0.7	1.4	0.7	-1.2	-0.8	-0.4
Seeking ratio, delayed vs. immediate footshock	4.0	4.6	6.8	2.5	-2.1	-2.6	0.7
Distance traveled before self-admin	1.8	1.9	2.2	-1.5	1.2	1.5	-1.3
Distance traveled after self-admin	1.1	1.2	1.8	-1.0	0.8	1.1	-1.3
Extensor digitorum longus weight	10.3	40.5	54.4	-7.4	7.3	7.2	-1.7
Bone: elastic displacement	0.3	0.3	1.2	0.2	-0.1	-0.2	1.1
Bone: elastic work	0.1	0.2	0.6	-0.1	0.2	0.2	0.8
Bone: endosteal estimation	0.7	1.5	3.1	-1.0	0.9	1.0	1.7
Bone: endosteal perimeter	0.1	0.2	0.9	-0.1	-0.1	0.2	0.9
Epididymis fat weight	0.2	0.5	0.9	0.6	-0.8	-0.5	-0.9
Delta time in closed arm before/after self-admin	1.5	1.5	2.0	-1.3	1.4	1.0	-1.1
Delta time in open arm before/after self-admin	0.3	0.3	0.5	0.7	-0.6	-0.6	0.3
Diff in mean of infusions in LGA sessions	1.5	1.7	2.6	-1.6	1.3	1.6	0.1
Delay discount exponential model param	0.6	0.6	1.4	0.8	-0.3	-0.7	1.2
Extinction: sum of active levers before priming	0.1	0.1	0.1	-0.4	0.2	0.1	-0.3
Active lever presses in extinction session 6	0.0	0.0	0.1	0.2	-0.1	-0.2	0.2
Bone: final force	1.1	1.8	2.5	-1.5	1.6	1.6	0.3
Bone: final moment	0.9	1.5	2.0	-1.4	1.4	1.4	0.3
Food consumed during 24 hour testing period	1.7	2.0	2.6	-1.6	1.5	1.4	-1.1
Glucose	1.4	2.2	3.5	-1.5	1.9	1.3	-1.1
Heart weight	0.7	0.9	1.8	1.1	-0.8	-1.3	-0.4
Delay discount hyperbolic model param	0.9	0.9	1.5	1.0	-0.6	-1.0	1.2
Intermittent access intake day 1-15 change	1.7	1.7	2.8	1.7	-1.2	-1.5	0.0
Intermittent access intake escalation	1.2	1.1	1.9	1.4	-1.1	-1.2	0.1
Intermittent access intake escalation 2	3.0	3.0	4.9	2.2	-1.7	-2.0	0.6
Intermitt. access day 1 inactive lever presses	0.4	0.4	1.6	-0.2	0.1	0.1	-1.3
Intermitt. access day 15 inactive lever presses	2.8	3.1	4.1	2.0	-1.8	-2.0	-1.1
Intermitt. access escalation Index	0.2	0.2	0.7	-0.3	0.0	0.1	-0.9
Intermittent access day 1 total infusions	4.1	4.7	6.1	2.4	-2.5	-2.0	1.7
Intermittent access day 15 total infusions	6.5	7.3	10.0	3.2	-3.0	-2.7	1.5
Intermittent access terminal intake (last 3 days)	6.7	7.3	10.1	3.2	-3.1	-2.8	1.2
Intermittent access total infusions	5.6	6.3	9.2	2.9	-3.0	-2.5	1.3
Intermittent access day 1 locomotion	0.8	0.9	1.4	1.1	-1.2	-0.8	0.5
Intermittent access day 15 total locomotion	0.6	0.6	0.9	0.9	-0.5	-0.8	0.9
Intermittent access total locomotion	1.6	1.8	2.8	1.6	-1.7	-1.3	0.7
Intermittent access standard deviation	2.6	2.8	4.3	1.9	-2.1	-1.7	-0.3
Left kidney weight	0.5	1.3	2.3	0.8	-1.3	-0.8	-1.5
Right kidney weight	0.7	2.0	4.3	0.9	-1.4	-0.9	-2.1
Cocaine induced anxiety	0.1	0.2	0.5	0.2	-0.1	-0.3	-0.7
Post-drug Anxiety	0.5	0.5	0.8	-0.9	0.8	0.5	-0.5
Baseline Anxiety	0.1	0.1	0.4	-0.1	0.3	-0.1	0.7
Tail length	0.5	1.5	2.2	-1.2	1.4	1.5	-0.7
Length with tail	0.0	0.1	0.1	0.3	0.0	-0.1	0.4
Length without tail	1.6	3.6	4.3	2.1	-1.8	-2.0	1.7
Times rat made contact with spout	0.2	0.2	0.5	-0.4	0.2	0.3	-0.7
Lifetime Intake	6.2	7.1	10.2	3.1	-3.2	-2.6	1.3
Liver weight, left	1.6	2.5	3.9	-1.8	2.0	1.7	-0.3
Liver weight, right	0.2	0.3	0.9	0.3	-0.2	-0.2	-1.0
Locomotor activity	1.2	2.0	2.8	-1.3	1.5	1.7	-1.0
Locomotor testing distance	0.4	0.7	1.0	-0.8	1.0	1.0	-0.7
Locomotor testing rearing	0.4	0.7	0.8	0.8	-0.7	-0.8	-0.9
Locomotion in novel chamber	1.8	2.2	3.2	-1.6	1.8	1.7	0.2
Locomotion in novel chamber post-restriction	0.2	0.2	0.8	-0.1	0.2	0.0	-0.9
Fecal boli incidents, locomotor time 1	0.2	0.2	0.4	0.4	-0.5	-0.4	0.7
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	0.7	-0.1	-0.6	-0.3
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.2	0.3	-0.2	0.2
Bouts of movement, locomotor time 1	1.4	1.6	4.8	0.4	-1.0	-0.6	-2.2
Total resting periods, locomotor time 1	0.9	1.0	1.9	0.6	-1.0	-0.8	-1.4
Rest time, locomotor task time 1	0.5	0.6	1.4	0.4	0.8	-0.5	-1.2
Distance moved, locomotor task time 1	0.4	0.4	0.7	-0.8	-0.1	0.8	0.4
Vertical activity count, locomotor time 1	1.3	1.4	2.2	-1.5	0.9	1.5	0.5
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.4	-0.4	0.6	0.3	0.5
Bouts of movement, locomotor time 2	1.7	1.8	7.1	-0.4	0.2	0.1	-2.7
Total resting periods, locomotor time 2	2.2	2.3	9.0	-0.4	0.5	0.1	-3.0
Rest time, locomotor task time 2	1.2	1.3	3.5	-0.4	1.3	0.2	-1.9
Distance moved, locomotor task time 2	0.2	0.2	0.3	-0.5	-0.4	0.6	0.4
Vertical activity count, locomotor time 2	2.4	2.6	4.5	-2.1	1.1	2.1	0.6
Light reinforcement 1	0.1	0.2	0.4	-0.1	0.5	0.1	-0.6
Light reinforcement 2	1.7	2.3	3.8	-2.0	1.4	1.8	-0.4
Bone: marrow area	0.8	1.6	2.9	-1.1	1.0	1.2	1.7
Bone: maximum diameter	0.8	1.5	2.3	-1.5	1.1	1.5	-0.5
Bone: maximum force	0.9	1.5	2.1	-1.4	1.4	1.4	-0.1
Bone: maximum moment	0.7	1.1	1.6	-1.3	1.2	1.2	-0.1
Mean time between licks in bursts	0.6	0.9	3.3	0.4	-0.3	-0.3	1.8
Mean num. licks in bursts	0.0	0.0	0.0	0.0	0.2	-0.1	-0.1
Cd content in liver	0.8	0.9	2.1	-0.7	0.5	0.8	-1.5
Co content in liver	1.3	1.5	5.2	-0.6	0.4	0.7	-2.3
Cu content in liver	2.5	3.1	5.2	1.9	-2.3	-1.8	0.0
Fe content in liver	0.7	0.8	3.2	0.1	-0.2	-0.1	1.8
K content in liver	1.2	1.2	1.8	1.3	-1.3	-1.1	0.4
Mg content in liver	1.1	1.1	1.4	1.0	-1.1	-0.8	1.2
Mn content in liver	0.2	0.2	0.5	0.4	-0.3	-0.4	0.7
Na content in liver	0.1	0.1	0.4	-0.0	0.0	-0.0	-0.6
Rb content in liver	0.0	0.0	0.0	0.1	0.0	-0.0	-0.1
Se content in liver	0.2	0.3	0.5	0.5	-0.7	-0.6	-0.2
Sr content in liver	0.1	0.1	0.1	-0.2	0.1	0.1	0.4
Zn content in liver	1.6	1.7	2.5	1.4	-1.6	-1.5	-0.1
Bone: minimum diameter	2.0	3.7	4.6	-1.8	1.7	1.9	2.1
Time in familiar zone, hab. session 1	0.7	0.7	2.7	-0.1	-0.0	-0.0	-1.7
Time in novel zone, hab. session 1	0.7	0.7	0.8	0.9	-0.7	-0.9	0.8
Total zone transitions, hab. session 1	0.2	0.3	0.9	-0.3	0.6	0.3	0.9
Total locomotion distance, hab. session 1	0.5	0.6	2.5	-0.0	0.3	0.1	1.6
Locomotion velocity, hab. session 1	0.7	0.9	2.3	-0.5	0.8	0.7	1.5
Time in familiar zone, hab. session 2	1.8	1.8	2.0	1.3	-1.4	-1.4	-1.3
Time in novel zone, hab. session 2	0.9	0.9	1.2	-0.9	1.1	0.8	1.0
Total zone transitions, hab. session 2	0.0	0.0	0.0	-0.0	0.2	-0.0	-0.2
Total locomotion distance, hab. session 2	0.2	0.2	0.6	-0.3	0.4	0.2	0.8
Locomotion velocity, hab. session 2	0.1	0.2	0.5	-0.1	0.3	0.2	0.7
Novel to familiar place preference ratio	0.7	0.7	1.1	-1.0	1.0	0.9	-0.2
Novelty place preference	0.6	0.6	0.8	-0.9	0.9	0.8	-0.4
Time in novel zone, NPP test	0.9	0.9	1.2	-1.0	1.1	0.9	-0.8
Total zone transitions, NPP test	0.0	0.1	0.2	-0.2	0.4	0.2	0.1
Total locomotion distance, NPP test	0.2	0.2	0.4	-0.3	0.5	0.3	0.6
Locomotion velocity, NPP test	0.2	0.3	1.0	0.1	0.1	-0.1	1.0
Intraocular pressure	2.3	3.1	5.0	-2.2	2.0	1.9	-0.4
Delta distance traveled before/after self-admin	0.2	0.2	0.3	0.5	-0.5	-0.4	0.5
Delta ambulatory time before/after self-admin	0.9	1.0	1.5	1.1	-1.2	-1.0	0.5
Parametrial fat weight	0.1	0.1	0.2	-0.3	0.3	0.2	-0.4
Pavlov. Cond. lever latency	0.7	0.9	1.3	0.7	-0.9	-1.1	-1.0
Pavlov. Cond. magazine entry latency	0.5	0.6	0.9	-0.8	1.0	0.8	0.5
Pavlov. Cond. change in total contacts	2.9	3.1	4.5	-1.9	2.0	2.1	0.4
Pavlov. Cond. index score	0.9	1.1	1.7	-1.0	1.2	1.3	0.4
Pavlov. Cond. latency score	0.7	0.9	1.6	-0.9	1.1	1.3	0.4
Pavlov. Cond. lever contacts	1.1	1.3	2.1	-0.8	1.0	1.2	1.5
Pavlov. Cond. magazine entry number	1.2	1.4	2.1	1.4	-1.5	-1.3	0.1
Pavlov. Cond. intertrial magazine entries	2.4	2.9	3.7	1.9	-1.9	-1.8	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.9	-1.1	1.2	1.4	0.2
Pavlov. Cond. response bias	1.4	1.7	2.4	-1.3	1.6	1.4	0.7
Pavlov. Cond. lever latency	0.8	1.1	1.5	-1.2	1.2	1.1	-0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.4	0.3	0.4	0.2
Pavlov. Cond. change in total contacts	0.4	0.6	2.3	0.0	-0.1	0.1	1.5
Pavlov. Cond. index score	0.2	0.2	0.9	0.1	-0.1	-0.1	0.9
Pavlov. Cond. latency score	0.1	0.2	0.5	0.2	-0.3	-0.2	0.7
Pavlov. Cond. lever contacts	0.7	1.0	1.2	1.0	-1.1	-1.0	0.9
Pavlov. Cond. magazine entry number	0.3	0.3	0.4	0.6	-0.7	-0.6	-0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.2	-0.4	0.4	0.5	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	0.3	-0.3	-0.3	0.9
Pavlov. Cond. response bias	0.4	0.5	1.6	0.4	-0.4	-0.3	1.2
Time in closed arm before self-admin	1.9	2.2	3.1	1.8	-1.6	-1.6	0.7
Time in closed arm after self-admin	0.3	0.3	1.0	-0.3	0.1	0.3	-1.0
Time in open arm before self-admin	0.8	0.9	1.2	-1.1	1.1	1.0	0.4
Time in open arm after self-admin	0.7	0.8	1.6	-0.9	1.3	0.9	0.1
Bone: periosteal estimation	1.4	2.9	3.5	-1.8	1.7	1.9	1.3
Bone: periosteal perimeter	0.3	0.5	0.9	-0.9	0.7	1.0	0.2
Bone: post-yield work	0.7	1.0	1.3	1.0	-1.1	-1.1	-0.8
Progressive ratio test 1 active lever presses	4.0	4.2	6.3	2.4	-2.5	-2.1	-0.4
Progressive ratio test 1 breakpoint	3.7	3.9	6.0	2.4	-2.5	-2.0	-0.2
Progressive ratio test 1 inactive lever presses	0.6	0.7	1.1	0.9	-1.0	-0.8	-0.5
Progressive ratio test 2 active lever presses	2.3	2.5	4.0	2.0	-1.5	-1.7	0.9
Progressive ratio test 2 breakpoint	2.0	2.3	3.6	1.9	-1.4	-1.6	1.1
Progressive ratio test 2 inactive lever presses	1.6	1.8	2.9	1.6	-1.7	-1.4	0.1
Incentive Sensitization - Responses	1.7	1.7	3.6	1.3	-0.7	-1.1	1.9
Incentive Sensitization - Breakpoint	1.5	1.5	2.9	1.3	-0.7	-1.1	1.7
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.7	0.5	-0.4	-0.6	0.8
Progressive ratio	1.0	1.1	3.5	-0.3	0.8	0.4	-1.9
Food seeking constrained by brief footshock	3.3	4.1	5.3	-2.3	2.1	2.3	1.1
Seeking ratio, punishment vs. effort	1.5	1.8	6.4	-0.6	0.2	0.6	2.5
Retroperitoneal fat weight	0.1	0.3	0.4	0.6	-0.5	-0.6	0.2
Reaction time number correct	0.3	0.4	1.0	0.5	-0.4	-0.4	1.0
Reaction time mean minus median	0.8	1.1	2.8	-0.6	0.8	0.7	-1.7
Reaction time mean minus median AUC	1.2	1.6	2.2	-1.0	1.4	1.0	-1.5
Reaction time num false alarms	0.8	1.1	3.5	0.5	0.7	-0.5	1.9
Reaction time num false alarms AUC	0.9	1.2	3.1	0.7	0.8	-0.7	1.8
Reaction time trials correct on left	0.3	0.4	1.0	0.5	-0.4	-0.4	1.0
Reaction time trials on left	0.3	0.4	1.1	0.6	-0.4	-0.4	1.0
Reaction time mean	1.0	1.4	1.9	-1.3	1.4	1.3	-0.3
Reaction time mean AUC	1.1	1.5	2.0	-1.4	1.4	1.4	-0.3
Median of all reaction times	1.2	1.7	2.3	-1.5	1.5	1.5	0.2
Reaction time omissions	0.2	0.2	0.3	-0.5	0.5	0.6	-0.2
Reaction time false alarm rate	0.3	0.4	1.2	0.1	1.1	-0.2	0.6
Reaction time premature initiation rate	0.9	1.2	1.8	1.1	-1.3	-1.0	-0.9
Reaction time premature initiations	0.9	1.3	2.1	1.3	-1.4	-1.2	-0.4
Std. dev. reaction times	0.8	1.1	2.4	-0.8	0.8	0.9	-1.5
Reaction time trials completed	0.3	0.4	1.1	0.6	-0.4	-0.4	1.0
Reaction time trials AUC	0.4	0.5	1.4	0.6	-0.4	-0.4	1.2
Run reversals in cocaine runway, females	3.1	3.0	4.7	-2.0	1.6	2.2	-1.0
Run reversals in cocaine runway, males	3.4	3.3	5.7	-1.9	2.4	2.0	0.1
Latency to leave start box in cocaine runway	0.6	0.6	1.4	0.6	-1.2	-0.7	0.2
Latency to leave start box in cocaine runway, F	2.6	2.8	4.8	1.7	-2.2	-1.8	0.5
Latency to leave start box in cocaine runway, M	0.5	0.5	0.7	-0.8	0.6	0.8	0.1
Std. dev. time between licks in bursts	0.5	0.5	1.7	0.4	-0.1	-0.5	1.3
Total sessions with >9 infusions	3.0	3.3	5.1	2.3	-2.2	-1.8	0.3
Short access day 1 total inactive lever presses	1.7	1.9	3.6	1.9	-1.3	-1.6	0.0
Short access day 10 total inactive lever presses	0.5	0.6	2.2	-0.4	-0.1	0.0	-1.5
Short access day 1 total infusions	2.8	3.0	4.7	2.0	-2.2	-1.7	0.1
Short access day 10 total infusions	5.7	6.3	10.5	2.8	-3.2	-2.6	0.4
Short access total infusions	6.3	7.1	11.0	3.0	-3.3	-2.7	1.0
Short access day 1 locomotion	0.5	0.5	1.5	0.4	-0.6	-0.2	-1.2
Short access day 10 total locomotion	0.1	0.1	0.1	-0.2	-0.2	0.3	-0.3
Short access total locomotion	0.7	0.7	1.7	0.8	-1.3	-0.6	-0.4
One hour access (0.3 mA shock)	2.5	2.9	4.7	2.2	-1.9	-1.6	1.0
Compulsive drug intake	3.1	3.2	5.2	-2.2	1.6	2.3	-0.3
One hour access (shock baseline)	6.1	7.1	10.7	3.3	-2.9	-2.9	0.9
Social response proportion	0.4	0.4	1.2	-0.1	0.5	-0.0	-1.1
Social responses	0.9	1.2	3.0	-0.5	1.2	0.2	-1.7
Social time	0.9	1.2	2.5	1.4	-0.5	-1.6	0.4
Soleus weight	1.4	4.0	6.0	-2.4	2.0	2.2	-1.0
Bone: stiffness	0.3	0.4	0.6	-0.8	0.6	0.6	-0.5
Tibialis anterior weight	9.9	34.0	45.6	-6.7	6.8	6.7	-0.1
Time to tail flick, vehicle, before self-admin	0.7	0.7	0.7	0.8	-0.8	-0.9	0.8
Time to tail flick, vehicle, after self-admin	1.4	1.5	1.9	1.2	-1.3	-1.1	1.4
Time to tail flick, test, before self-admin	0.2	0.2	0.3	0.3	-0.5	-0.2	-0.5
Time to tail flick, test, after self-admin	1.7	1.7	2.6	1.5	-1.6	-1.4	-0.1
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	1.4	1.2	-1.1	-1.0	1.1
Delta time to tail flick, test, before/after SA	0.3	0.3	0.6	0.4	-0.4	-0.4	-0.8
Tibia length	0.5	1.5	2.2	1.3	-1.5	-1.4	-0.3
Ambulatory time before self-admin	1.2	1.2	1.5	-1.1	1.2	1.1	-1.0
Ambulatory time after self-admin	0.1	0.1	0.2	-0.3	0.2	0.4	-0.4
Bone: tissue strength	1.3	1.3	1.9	1.4	-1.2	-1.4	-0.1
Total heroin consumption	0.1	0.1	0.4	-0.0	0.2	-0.1	0.6
Bone: trabecular number	0.4	0.6	0.8	0.7	-0.9	-0.8	0.7
Bone: trabecular spacing	0.2	0.2	0.3	-0.6	0.5	0.5	-0.1
Bone: trabecular thickness	1.0	1.2	1.5	1.0	-1.2	-1.1	1.0
Bone: trabecular tissue density	0.4	0.5	1.8	-0.3	0.3	-0.1	-1.4
Water consumed over 24 hours	0.5	0.7	0.9	-1.0	0.9	0.8	-0.6
Number of responses in last shaping day	0.2	0.2	0.7	0.1	-0.1	0.1	-0.8