One hour access (shock baseline)

Tags: Behavior · Cocaine

Project: p50_paul_meyer_2020

2 loci · 2 genes with independent associations · 2 total associated genes

Significant Loci

#	Chr	Start pos	End pos	# assoc genes	# joint models	Best TWAS P	Best GWAS P	Cond GWAS P	Joint genes
1	chr1	79485178	80785451	1	1	3.99e-08	2.65e-02	5.37e-01	Zfp575
2	chr8	33211184	34601262	1	1	7.66e-12	2.68e-01	1.38e-14	Ddx25

Pleiotropic Associations

Trait	Chi² ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	Corr P	Genes
BMI with tail	1.62	1	0	0	1e+00	Ddx25
BMI without tail	3.34	2	0	0	1e+00	Ddx25 Zfp575
Left kidney weight	2.5	1	0	0	1e+00	Zfp575
Right kidney weight	2.13	2	0	0	1e+00	Ddx25 Zfp575
Tail length	4.24	2	0	0	1e+00	Ddx25 Zfp575
Length without tail	4.72	2	0	0	1e+00	Ddx25 Zfp575
Parametrial fat weight	2.77	2	0	0	1e+00	Ddx25 Zfp575
Patch foraging total patch changes 24 sec	4.53	1	0	0	1e+00	Zfp575
Patch foraging water rate 6 sec	4.97	1	0	0	1e+00	Zfp575
Locomotor activity	4.49	1	0	0	1e+00	Ddx25
Locomotor testing distance	4.75	1	0	0	1e+00	Ddx25
Locomotor testing rearing	3.33	1	0	0	1e+00	Ddx25
Reaction time number correct	4.8	1	0	0	1e+00	Zfp575
Reaction time mean minus median AUC	3.91	1	0	0	1e+00	Ddx25
Reaction time trials correct on left	4.8	1	0	0	1e+00	Zfp575
Reaction time trials on left	4.9	1	0	0	1e+00	Zfp575
Reaction time mean	4.79	1	0	0	1e+00	Ddx25
Reaction time trials completed	4.9	1	0	0	1e+00	Zfp575
Reaction time trials AUC	4.63	1	0	0	1e+00	Zfp575
Social responses	4.22	1	0	0	1e+00	Zfp575
Conditioned reinforcement - actives	5.59	1	0	0	1e+00	Zfp575
Conditioned reinforcement - inactives	9.88	2	0	0	1e+00	Ddx25 Zfp575
Conditioned locomotion	5.33	1	0	0	1e+00	Zfp575
Intermittent access intake day 1-15 change	78.98	1	1	50	1e+00	Ddx25
Intermittent access intake escalation	41.26	1	1	50	1e+00	Ddx25
Intermittent access intake escalation 2	33.1	1	1	50	1e+00	Ddx25
Intermitt. access day 1 inactive lever presses	25.7	1	1	50	1e+00	Ddx25
Intermitt. access day 15 inactive lever presses	40.88	1	1	50	1e+00	Ddx25
Intermitt. access escalation Index	14.59	1	0	0	1e+00	Ddx25
Intermittent access day 15 total infusions	29.23	2	1	50	1e+00	Ddx25 Zfp575
Intermittent access terminal intake (last 3 days)	27.22	2	1	50	1e+00	Ddx25 Zfp575
Intermittent access total infusions	19.23	2	1	50	1e+00	Ddx25 Zfp575
Intermittent access day 1 locomotion	5.4	1	0	0	1e+00	Zfp575
Intermittent access total locomotion	11.21	1	0	0	1e+00	Zfp575
Intermittent access standard deviation	12.4	2	0	0	1e+00	Ddx25 Zfp575
Cocaine induced anxiety	12.68	1	0	0	1e+00	Ddx25
Baseline Anxiety	5.61	1	0	0	1e+00	Ddx25
Lifetime Intake	26.35	2	1	50	1e+00	Ddx25 Zfp575
Incentive Sensitization - Responses	20.69	2	0	0	1e+00	Ddx25 Zfp575
Incentive Sensitization - Breakpoint	24.16	2	1	50	1e+00	Ddx25 Zfp575
Progressive ratio test 1 active lever presses	8.93	1	0	0	1e+00	Ddx25
Progressive ratio test 1 breakpoint	6.86	1	0	0	1e+00	Ddx25
Progressive ratio test 1 inactive lever presses	14.06	1	0	0	1e+00	Ddx25
Progressive ratio test 2 active lever presses	11.94	2	0	0	1e+00	Ddx25 Zfp575
Progressive ratio test 2 breakpoint	14.19	2	0	0	1e+00	Ddx25 Zfp575
Progressive ratio test 2 inactive lever presses	22.03	2	1	50	1e+00	Ddx25 Zfp575
Total sessions with >9 infusions	15.26	2	0	0	1e+00	Ddx25 Zfp575
Short access day 1 total inactive lever presses	26.73	1	1	50	1e+00	Zfp575
Short access day 1 total infusions	27.87	2	1	50	1e+00	Ddx25 Zfp575
Short access day 10 total infusions	32.96	1	1	50	1e+00	Ddx25
Short access total infusions	54.56	1	1	50	1e+00	Ddx25
Short access day 10 total locomotion	11.38	1	0	0	1e+00	Ddx25
Compulsive drug intake	14.12	1	0	0	1e+00	Zfp575
One hour access (0.3 mA shock)	58.39	2	2	100	1e+00	Ddx25 Zfp575
Number of responses in last shaping day	22.04	2	1	50	1e+00	Ddx25 Zfp575
Bone: cortical area	7.52	1	0	0	1e+00	Ddx25
Bone: cortical thickness	4.39	1	0	0	1e+00	Ddx25
Bone: cortical thickness	5.77	1	0	0	1e+00	Ddx25
Bone: final force	5.29	1	0	0	1e+00	Ddx25
Bone: final moment	4.65	1	0	0	1e+00	Ddx25
Bone: maximum force	6.75	1	0	0	1e+00	Ddx25
Bone: maximum moment	5.84	1	0	0	1e+00	Ddx25
Bone: minimum diameter	3.6	1	0	0	1e+00	Ddx25
Bone: periosteal estimation	3.75	1	0	0	1e+00	Ddx25
Bone: stiffness	4.98	1	0	0	1e+00	Ddx25
Bone: trabecular thickness	4.3	1	0	0	1e+00	Ddx25
Distance traveled before self-admin	16.37	2	0	0	1e+00	Ddx25 Zfp575
Distance traveled after self-admin	10.59	2	0	0	1e+00	Ddx25 Zfp575
Delta time in closed arm before/after self-admin	6.42	1	0	0	1e+00	Ddx25
Extinction: sum of active levers before priming	20.46	2	0	0	1e+00	Ddx25 Zfp575
Active lever presses in extinction session 6	9.2	2	0	0	1e+00	Ddx25 Zfp575
Delta distance traveled before/after self-admin	6.76	1	0	0	1e+00	Ddx25
Delta ambulatory time before/after self-admin	14.46	1	0	0	1e+00	Ddx25
Time in closed arm after self-admin	5	1	0	0	1e+00	Zfp575
Time in open arm before self-admin	21.1	1	0	0	1e+00	Zfp575
Time to tail flick, vehicle, before self-admin	9.26	1	0	0	1e+00	Ddx25
Time to tail flick, vehicle, after self-admin	9	1	0	0	1e+00	Zfp575
Time to tail flick, test, before self-admin	8.19	2	0	0	1e+00	Ddx25 Zfp575
Ambulatory time before self-admin	18.76	2	1	50	1e+00	Ddx25 Zfp575
Ambulatory time after self-admin	5.96	2	0	0	1e+00	Ddx25 Zfp575
Total heroin consumption	8.9	1	0	0	1e+00	Ddx25
Change in fecal boli incidents, locomotor task	5.67	1	0	0	1e+00	Zfp575
Vertical activity count, locomotor time 1	13.25	1	0	0	1e+00	Zfp575
Weight adjusted by age	15.78	1	0	0	1e+00	Zfp575
Seeking ratio, delayed vs. immediate footshock	10.88	1	0	0	1e+00	Zfp575
Locomotion in novel chamber	6.51	1	0	0	1e+00	Zfp575
Food seeking constrained by brief footshock	11.04	1	0	0	1e+00	Zfp575
Run reversals in cocaine runway, males	8.37	1	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway	5.91	1	0	0	1e+00	Ddx25
Latency to leave start box in cocaine runway, M	12.73	2	0	0	1e+00	Ddx25 Zfp575
Sr content in liver	7.99	2	0	0	1e+00	Ddx25 Zfp575

Associations by panel

Tissue	RNA modality	# hits	Avg chisq
Adipose	alternative polyA	0	1.12
Adipose	alternative TSS	0	1.11
Adipose	gene expression	1	1.13
Adipose	isoform ratio	0	1.13
Adipose	intron excision ratio	0	1.07
Adipose	mRNA stability	0	1.15
BLA	alternative polyA	0	1.16
BLA	alternative TSS	0	1.18
BLA	gene expression	0	1.16
BLA	isoform ratio	0	1.15
BLA	intron excision ratio	0	1.11
BLA	mRNA stability	0	1.2
Brain	alternative polyA	0	1.16
Brain	alternative TSS	0	1.11
Brain	gene expression	0	1.17
Brain	isoform ratio	0	1.19
Brain	intron excision ratio	0	1.18
Brain	mRNA stability	0	1.2
Eye	alternative polyA	0	1.26
Eye	alternative TSS	0	1.06
Eye	gene expression	0	1.2
Eye	isoform ratio	0	1.18
Eye	intron excision ratio	0	1.14
Eye	mRNA stability	0	1.19
IL	alternative polyA	0	1.17
IL	alternative TSS	0	1.12
IL	gene expression	0	1.15
IL	isoform ratio	0	1.17
IL	intron excision ratio	0	1.18
IL	mRNA stability	0	1.3
LHb	alternative polyA	0	1.11
LHb	alternative TSS	0	1.26
LHb	gene expression	0	1.19
LHb	isoform ratio	0	1.26
LHb	intron excision ratio	0	1.01
LHb	mRNA stability	0	1.24
Liver	alternative polyA	0	1.21
Liver	alternative TSS	0	1.24
Liver	gene expression	0	1.13
Liver	isoform ratio	0	1.18
Liver	intron excision ratio	0	1.14
Liver	mRNA stability	0	1.13
NAcc	alternative polyA	0	1.16
NAcc	alternative TSS	0	1.13
NAcc	gene expression	0	1.18
NAcc	isoform ratio	0	1.15
NAcc	intron excision ratio	0	1.14
NAcc	mRNA stability	0	1.18
OFC	alternative polyA	0	1.23
OFC	alternative TSS	0	1.11
OFC	gene expression	0	1.14
OFC	isoform ratio	0	1.17
OFC	intron excision ratio	0	1.09
OFC	mRNA stability	0	1.21
PL	alternative polyA	0	1.21
PL	alternative TSS	0	1.13
PL	gene expression	0	1.15
PL	isoform ratio	0	1.2
PL	intron excision ratio	0	1.19
PL	mRNA stability	1	1.23
pVTA	alternative polyA	0	1.22
pVTA	alternative TSS	0	1.24
pVTA	gene expression	0	1.18
pVTA	isoform ratio	0	1.23
pVTA	intron excision ratio	0	1.16
pVTA	mRNA stability	0	1.27
RMTg	alternative polyA	0	1.23
RMTg	alternative TSS	0	0.95
RMTg	gene expression	0	1.18
RMTg	isoform ratio	0	1.12
RMTg	intron excision ratio	0	1.17
RMTg	mRNA stability	0	1.4