Ccdc92b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Ccdc92b	0.03	0.03	8.3e-04	0.04	0.02	0.03	0.03	4.3e-05	1.1e-03	3.7e-04	2.8e-04
2	Adipose	mRNA stability	Ccdc92b	0.07	0.04	1.4e-06	0.02	0.03	0.02	0.02	3.0e-03	4.4e-04	6.0e-03	1.6e-03
3	NAcc	mRNA stability	Ccdc92b	0.03	0.02	2.9e-04	0.03	0.03	0.03	0.03	2.0e-05	5.5e-05	4.0e-05	3.3e-05
4	Adipose	gene expression	Ccdc92b	0.16	0.07	1.2e-15	0.07	0.11	0.1	0.11	1.4e-08	2.8e-12	1.0e-11	8.5e-12
5	OFC	mRNA stability	Ccdc92b	0.13	0.09	8.6e-03	0.06	0.09	0	0.09	1.4e-02	3.6e-03	2.4e-01	4.4e-03
6	BLA	gene expression	Ccdc92b	0.07	0.05	1.7e-03	0.02	0.01	0.01	0.01	3.4e-02	6.3e-02	9.2e-02	9.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	3.8	6.6	9.2	3.0	3.0	2.9	2.9	1.6	-1.4
Area under the delay curve	0.4	0.5	0.9	-0.6	-0.8	-1.0	-0.8	-0.3	0.2
BMI with tail	1.2	4.1	4.8	2.1	2.2	2.1	2.0	1.9	-1.8
BMI without tail	0.7	2.3	6.0	1.3	2.2	1.1	2.4	0.0	0.2
Body weight	0.9	4.1	11.0	1.4	2.7	1.1	3.3	-1.0	1.4
Weight adjusted by age	1.3	2.0	2.8	1.7	1.2	1.2	0.8	1.7	-1.7
Bone surface	3.9	7.1	9.5	2.9	2.9	3.1	2.6	2.2	-2.1
Bone volume	4.1	7.4	9.6	3.0	3.0	3.1	2.7	2.2	-2.1
Breakpoint value in progressive ratio session	0.9	1.1	2.5	1.1	1.5	1.0	1.6	0.1	0.1
Number of licking bursts	0.2	0.3	0.7	-0.2	-0.8	-0.6	-0.8	-0.4	0.4
Context. condit. distance diff. score	1.3	1.6	2.9	1.7	1.5	1.4	1.4	0.5	-0.5
Locomotion velocity, session 1	2.0	2.2	5.1	1.3	2.1	1.4	2.3	0.1	0.2
Locomotion distance, session 1	0.4	0.5	0.8	0.7	0.9	0.8	0.8	0.5	-0.6
Locomotion velocity, session 2	0.5	0.6	1.2	0.9	1.1	0.7	1.1	0.3	-0.3
Locomotion distance, session 2	1.4	2.0	2.6	1.6	1.6	1.6	1.4	1.0	-1.1
Locomotion velocity, session 3	5.4	6.2	9.7	-3.1	-2.5	-3.0	-2.1	-2.2	1.8
Locomotion distance, session 3	0.1	0.1	0.4	-0.3	-0.1	0.1	-0.1	0.3	-0.7
Stereotopy head waving bouts, day 3	0.3	0.4	1.0	-0.5	-0.1	-0.6	0.1	-1.0	0.9
Stereotopy head waving duration, day 3	0.2	0.2	0.4	-0.3	-0.6	-0.6	-0.6	-0.3	0.2
Locomotion velocity, session 7	1.3	1.4	2.0	0.9	1.2	1.3	0.9	1.4	-1.3
Locomotion distance, session 7	2.7	3.4	4.1	1.8	1.8	2.0	1.4	2.0	-2.0
Stereotopy head waving bouts, day 7	0.6	0.6	1.3	0.8	1.1	0.8	1.2	-0.1	0.1
Stereotopy head waving duration, day 7	0.8	1.0	1.6	1.1	1.2	1.2	1.2	0.4	-0.3
Locomotion velocity, session 8	0.4	0.5	0.8	0.9	0.7	0.9	0.6	0.5	-0.7
Locomotion distance, session 8	2.1	3.1	4.8	2.1	2.2	1.9	2.1	0.6	-0.7
Degree of sensitization distance	1.3	1.3	2.0	1.4	1.4	1.2	1.2	0.8	-0.5
Degree of sensitization stereotypy	0.9	1.0	1.9	1.1	1.3	1.1	1.4	0.1	-0.0
Conditioned locomotion	0.5	0.6	0.9	-0.8	-1.0	-0.8	-0.9	-0.5	0.3
Cocaine response after cond. corrected	0.1	0.2	0.4	0.1	0.2	0.0	0.4	-0.6	0.6
Cocaine response after cond. not corrected	0.2	0.3	0.6	0.4	0.6	0.3	0.8	-0.4	0.5
Cocaine response before conditioning	0.8	1.0	1.5	0.9	1.2	1.1	1.2	0.8	-0.5
Saline control response	0.7	1.0	1.6	1.0	0.8	0.9	0.5	1.3	-1.3
Bone: connectivity density	5.7	8.8	12.3	3.4	3.4	3.5	3.2	2.0	-1.8
Bone: cortical apparent density	0.3	0.3	0.8	-0.1	-0.6	-0.4	-0.9	0.5	-0.7
Bone: cortical area	1.3	2.0	3.3	-1.8	-1.6	-1.7	-1.5	-0.6	0.4
Bone: cortical porosity	0.2	0.2	0.4	0.6	0.6	0.6	0.6	0.2	-0.2
Bone: cortical porosity	0.0	0.0	0.0	0.2	0.1	0.1	0.1	-0.1	0.1
Bone: cortical thickness	5.5	9.1	13.0	-3.6	-3.2	-3.5	-2.7	-2.6	2.2
Bone: cortical thickness	1.7	2.1	2.9	-1.7	-1.2	-1.5	-0.8	-1.7	1.5
Bone: cortical tissue density	0.2	0.2	0.5	0.0	-0.5	-0.3	-0.7	0.5	-0.6
Condit. Reinf. active minus inactive responses	0.5	0.5	0.9	-0.9	-0.5	-0.8	-0.3	-0.8	1.0
Condit. Reinf. active-inactive response ratio	3.5	3.8	5.4	-2.3	-1.5	-2.1	-0.9	-2.2	2.3
Condit. Reinf. active responses	0.2	0.2	0.3	0.5	0.5	0.5	0.4	0.5	-0.3
Condit. Reinf. inactive responses	4.5	5.5	8.0	2.7	1.8	2.5	1.0	2.8	-2.7
Incentive salience index mean	0.5	0.7	1.5	-1.0	-0.3	-0.7	0.1	-1.0	1.2
Condit. Reinf. lever presses	0.5	0.7	1.5	-0.3	0.7	0.1	1.1	-0.9	1.2
Condit. Reinf. active minus inactive responses	1.0	1.3	1.7	1.3	1.1	1.2	0.8	1.2	-1.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	0.1	0.1	-0.0	0.2	-0.2	0.1
Condit. Reinf. active responses	2.3	3.3	5.0	1.9	1.5	1.8	1.0	2.2	-2.1
Condit. Reinf. inactive responses	4.1	5.3	9.7	2.1	1.6	2.3	0.9	3.1	-3.0
Condit. Reinf. lever presses	0.5	0.7	1.7	0.3	-0.2	0.4	-0.6	1.3	-1.3
Condit. Reinf. lever reinforcers received	2.4	3.4	5.7	1.8	1.4	1.8	0.9	2.4	-2.3
Conditioned reinforcement - actives	1.5	2.6	3.2	1.7	1.6	1.6	1.3	1.8	-1.7
Conditioned reinforcement - inactives	0.6	0.9	1.2	1.1	0.9	0.7	0.7	1.1	-1.1
Conditioned locomotion	0.3	0.3	0.7	-0.4	-0.7	-0.3	-0.8	0.5	-0.7
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.3	0.6	0.7	0.6	0.3	-0.3
Patch foraging indifference point AUC	0.3	0.4	1.1	0.4	-0.3	0.1	-0.6	0.9	-1.1
Delay disc. indifference point, 0s delay	0.3	0.4	0.4	0.6	0.7	0.7	0.6	0.6	-0.4
Delay disc. indifference point, 16s delay	0.3	0.4	0.8	-0.3	-0.8	-0.7	-0.9	0.2	-0.4
Delay disc. indifference point, 2s delay	0.4	0.4	1.0	-0.4	-0.7	-1.0	-0.7	-0.4	0.5
Delay disc. indifference point, 24s delay	0.1	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.2	-0.3
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	-0.1	-0.3	-0.7	-0.3	-0.5	0.4
Delay disc. indifference point, 8s delay	0.3	0.3	0.5	-0.6	-0.6	-0.7	-0.5	-0.4	0.4
Indifference point function ln k	0.4	0.7	1.5	0.4	1.1	0.9	1.2	0.0	0.1
Indifference point function log k	0.4	0.7	1.5	0.4	1.1	0.9	1.2	0.0	0.1
Patch foraging total patch changes 0 sec	0.2	0.3	0.7	0.4	0.6	0.8	0.6	0.4	-0.4
Patch foraging total patch changes 12 sec	0.6	0.7	0.9	-0.9	-0.8	-1.0	-0.6	-0.9	0.9
Patch foraging total patch changes 18 sec	0.1	0.2	0.4	-0.3	-0.6	-0.5	-0.5	-0.4	0.3
Patch foraging total patch changes 24 sec	0.2	0.4	0.7	-0.7	-0.9	-0.7	-0.8	-0.3	0.3
Patch foraging total patch changes 6 sec	0.1	0.2	0.5	0.0	-0.4	0.2	-0.6	0.6	-0.7
Patch foraging time to switch 0 sec	1.3	2.6	5.0	-1.3	-1.2	-1.7	-0.6	-2.1	2.2
Patch foraging water rate 0 sec	0.4	0.8	2.1	0.3	0.3	0.9	-0.1	1.3	-1.5
Patch foraging water rate 12 sec	0.1	0.1	0.3	0.2	0.5	0.3	0.4	0.3	-0.3
Patch foraging water rate 18 sec	2.4	3.7	4.9	1.9	2.2	2.1	1.9	1.8	-1.5
Patch foraging water rate 24 sec	0.2	0.3	0.7	0.0	0.3	0.5	0.2	0.8	-0.7
Patch foraging water rate 6 sec	0.1	0.2	0.4	-0.4	-0.5	-0.3	-0.6	0.3	-0.3
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.7	-0.3	-1.0	-0.3	-1.3	0.3	-0.7
Distance traveled before self-admin	1.9	2.5	4.7	-1.4	-2.1	-1.8	-2.2	-0.6	0.4
Distance traveled after self-admin	0.2	0.2	0.4	-0.5	-0.5	-0.6	-0.6	-0.0	-0.1
Extensor digitorum longus weight	4.6	18.0	23.6	4.7	4.4	4.9	3.7	4.0	-3.7
Bone: elastic displacement	0.4	0.4	1.1	-0.6	-0.9	-0.5	-1.0	0.1	-0.1
Bone: elastic work	5.6	7.2	11.7	-3.4	-2.9	-2.9	-2.5	-2.2	2.0
Bone: endosteal estimation	0.3	0.7	1.3	0.8	0.6	0.7	0.4	1.1	-1.1
Bone: endosteal perimeter	1.8	3.7	6.3	2.0	1.5	1.8	0.9	2.5	-2.4
Epididymis fat weight	7.3	25.1	38.2	6.0	6.2	5.3	6.0	2.8	-2.2
Delta time in closed arm before/after self-admin	0.3	0.2	0.7	0.3	-0.5	-0.4	-0.8	0.4	-0.4
Delta time in open arm before/after self-admin	0.8	0.8	1.3	0.9	1.0	1.1	1.1	0.4	-0.4
Diff in mean of infusions in LGA sessions	0.7	0.9	2.1	0.8	1.3	0.9	1.4	-0.1	0.3
Delay discount exponential model param	0.4	0.4	0.9	0.6	0.7	0.9	0.7	0.3	-0.2
Extinction: sum of active levers before priming	3.9	4.2	6.4	2.5	2.2	2.0	1.8	2.0	-1.8
Active lever presses in extinction session 6	3.1	3.0	4.2	1.9	2.0	1.9	1.8	1.4	-1.3
Bone: final force	1.5	2.3	4.4	-2.1	-1.1	-1.5	-0.5	-1.7	1.7
Bone: final moment	1.2	1.9	4.0	-2.0	-1.0	-1.4	-0.5	-1.5	1.4
Food consumed during 24 hour testing period	0.3	0.5	0.8	0.8	0.8	0.9	0.7	0.4	-0.3
Glucose	2.6	4.1	6.9	-2.1	-2.6	-2.3	-2.6	-1.0	0.8
Heart weight	0.7	1.1	2.6	0.8	1.3	1.2	1.6	-0.4	0.5
Delay discount hyperbolic model param	0.5	0.6	1.2	0.8	0.8	1.1	0.8	0.5	-0.5
Intermittent access intake day 1-15 change	0.6	1.1	2.5	0.6	-0.6	0.5	-1.1	1.5	-1.6
Intermittent access intake escalation	0.6	1.3	3.1	0.6	-0.5	0.6	-1.0	1.6	-1.7
Intermittent access intake escalation 2	0.8	0.9	1.8	0.1	-0.9	0.2	-1.3	1.1	-1.1
Intermitt. access day 1 inactive lever presses	0.4	1.6	3.2	-1.6	-1.5	-1.1	-1.8	0.4	-0.6
Intermitt. access day 15 inactive lever presses	0.4	0.8	1.8	0.2	-0.8	-0.7	-1.3	0.9	-1.1
Intermitt. access escalation Index	0.7	0.9	2.7	-0.1	0.3	-0.3	0.8	-1.5	1.6
Intermittent access day 1 total infusions	0.1	0.2	0.3	0.6	0.4	-0.1	0.2	0.6	-0.6
Intermittent access day 15 total infusions	1.2	1.7	3.8	1.3	0.4	1.0	-0.1	1.9	-2.0
Intermittent access terminal intake (last 3 days)	1.3	1.7	2.7	1.5	0.9	1.3	0.6	1.6	-1.6
Intermittent access total infusions	1.0	1.2	2.3	1.2	0.6	0.7	0.2	1.5	-1.5
Intermittent access day 1 locomotion	0.1	0.1	0.5	-0.4	0.0	-0.7	0.0	0.0	0.0
Intermittent access day 15 total locomotion	0.2	0.3	0.9	0.1	-0.3	-0.2	-0.6	0.8	-0.9
Intermittent access total locomotion	0.3	0.4	0.9	0.4	0.2	0.1	-0.0	1.0	-1.0
Intermittent access standard deviation	1.3	2.8	7.0	1.3	0.2	1.1	-0.6	2.6	-2.6
Left kidney weight	1.9	8.7	11.9	-3.1	-2.6	-3.3	-1.7	-3.4	3.3
Right kidney weight	1.7	7.7	12.3	-2.7	-2.0	-3.1	-1.1	-3.5	3.5
Cocaine induced anxiety	0.1	0.1	0.3	-0.4	-0.4	0.0	-0.5	0.1	-0.1
Post-drug Anxiety	0.4	0.4	1.0	-0.3	0.3	0.0	0.6	-0.9	1.0
Baseline Anxiety	0.6	0.7	1.6	0.6	1.0	0.4	1.3	-0.5	0.7
Tail length	1.0	4.0	9.8	-0.2	1.3	-0.3	2.2	-2.7	3.1
Length with tail	1.2	5.2	14.3	-0.5	0.9	-0.9	1.9	-3.3	3.8
Length without tail	0.4	1.3	2.5	0.4	1.1	0.2	1.6	-1.2	1.5
Times rat made contact with spout	1.7	2.0	3.7	-1.9	-1.0	-1.5	-0.6	-1.5	1.5
Lifetime Intake	0.8	0.9	1.9	1.1	0.6	0.6	0.3	1.4	-1.4
Liver weight, left	2.3	3.8	8.5	0.8	2.1	0.5	2.9	-1.9	2.3
Liver weight, right	2.1	3.8	9.3	1.4	2.5	1.0	3.1	-1.1	1.6
Locomotor activity	0.3	0.4	0.8	0.9	0.5	0.5	0.4	0.8	-0.7
Locomotor testing distance	0.1	0.1	0.3	0.5	0.2	0.3	0.1	0.4	-0.3
Locomotor testing rearing	0.7	1.4	2.4	1.4	0.6	1.2	0.3	1.6	-1.5
Locomotion in novel chamber	1.3	1.6	3.4	-0.3	-1.3	-0.2	-1.8	1.4	-1.6
Locomotion in novel chamber post-restriction	0.3	0.5	0.9	0.8	0.4	0.9	0.2	0.8	-0.8
Fecal boli incidents, locomotor time 1	0.2	0.3	0.8	-0.6	-0.3	-0.1	-0.1	-0.8	0.9
Change in fecal boli incidents, locomotor task	0.5	0.5	0.6	-0.7	-0.7	-0.6	-0.5	-0.8	0.8
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.4	0.0	0.2	0.6	0.2	0.3	-0.4
Bouts of movement, locomotor time 1	0.1	0.1	0.1	0.1	0.3	0.1	0.4	-0.1	0.4
Total resting periods, locomotor time 1	0.0	0.1	0.1	0.3	0.3	0.2	0.3	0.2	0.1
Rest time, locomotor task time 1	0.2	0.2	0.6	-0.4	-0.7	-0.4	-0.8	-0.0	0.2
Distance moved, locomotor task time 1	0.2	0.2	0.3	0.6	0.5	0.5	0.4	0.5	-0.5
Vertical activity count, locomotor time 1	0.3	0.7	0.9	0.8	0.9	0.9	0.9	0.7	-0.8
Time >=10cm from walls, locomotor time 2	0.3	0.4	1.2	-1.1	-0.7	-0.6	-0.6	-0.4	0.3
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.0	0.1	-0.2	0.1	0.0	0.0
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.2	0.4	0.1	0.4	0.2	-0.1
Rest time, locomotor task time 2	0.2	0.3	0.8	0.9	0.2	0.2	-0.0	0.8	-0.5
Distance moved, locomotor task time 2	0.1	0.1	0.2	-0.1	-0.3	0.2	-0.4	0.4	-0.4
Vertical activity count, locomotor time 2	0.3	0.4	0.6	-0.8	-0.5	-0.5	-0.3	-0.8	0.7
Light reinforcement 1	0.0	0.1	0.3	0.5	0.1	0.4	0.0	0.3	-0.1
Light reinforcement 2	2.3	3.5	5.1	-2.0	-1.8	-2.3	-1.5	-1.7	1.8
Bone: marrow area	0.3	0.6	1.2	0.8	0.6	0.6	0.4	1.1	-1.1
Bone: maximum diameter	0.4	0.7	2.0	0.4	0.1	0.5	-0.2	1.4	-1.4
Bone: maximum force	1.3	2.3	4.0	-2.0	-1.3	-1.6	-0.8	-1.6	1.5
Bone: maximum moment	1.1	1.9	3.5	-1.9	-1.2	-1.5	-0.8	-1.4	1.2
Mean time between licks in bursts	0.1	0.4	0.8	-0.1	0.4	-0.3	0.6	-0.8	0.9
Mean num. licks in bursts	0.3	0.4	1.2	-1.1	0.0	-0.5	0.4	-0.7	0.7
Cd content in liver	2.4	2.7	4.7	2.0	0.9	1.5	0.3	2.1	-2.2
Co content in liver	0.1	0.1	0.2	-0.5	-0.2	-0.3	-0.2	0.2	-0.1
Cu content in liver	0.8	0.9	1.4	-1.2	-1.1	-1.2	-1.0	-0.5	0.5
Fe content in liver	0.3	0.4	1.1	-0.2	0.2	-0.2	0.5	-0.9	1.0
K content in liver	1.1	1.1	2.5	-1.2	-0.1	-0.8	0.3	-1.3	1.6
Mg content in liver	0.2	0.2	0.5	0.1	0.4	0.4	0.2	0.7	-0.5
Mn content in liver	0.3	0.3	0.5	0.6	0.4	0.7	0.3	0.7	-0.6
Na content in liver	2.5	2.7	4.3	-2.1	-1.5	-2.0	-1.2	-1.4	1.3
Rb content in liver	4.5	5.2	7.2	2.5	2.2	2.7	1.8	2.3	-2.0
Se content in liver	0.7	0.8	1.4	-1.2	-0.9	-1.0	-0.7	-0.7	0.8
Sr content in liver	1.3	1.1	1.3	1.2	1.0	1.1	0.8	1.1	-1.1
Zn content in liver	0.1	0.1	0.3	-0.1	0.4	-0.0	0.5	-0.4	0.5
Bone: minimum diameter	0.5	0.8	1.8	-1.0	-0.9	-1.3	-0.7	-0.8	0.7
Time in familiar zone, hab. session 1	1.4	1.3	2.3	1.2	0.6	1.3	0.2	1.5	-1.4
Time in novel zone, hab. session 1	0.9	0.9	1.9	-0.8	-0.6	-1.0	-0.2	-1.3	1.4
Total zone transitions, hab. session 1	2.5	3.5	4.8	2.2	1.5	1.9	1.0	2.2	-2.2
Total locomotion distance, hab. session 1	0.7	1.0	1.7	1.3	1.0	1.1	0.7	1.0	-1.0
Locomotion velocity, hab. session 1	0.7	0.9	1.2	1.1	0.9	1.0	0.6	1.0	-1.0
Time in familiar zone, hab. session 2	2.0	2.1	3.0	1.7	1.4	1.6	1.0	1.5	-1.4
Time in novel zone, hab. session 2	4.6	4.7	6.6	-2.6	-2.1	-2.5	-1.6	-2.2	1.9
Total zone transitions, hab. session 2	0.9	1.2	1.8	1.4	1.2	1.2	1.1	0.7	-0.7
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.0	0.2	-0.1	0.3	-0.4	0.4
Locomotion velocity, hab. session 2	0.0	0.1	0.2	-0.1	0.1	-0.2	0.2	-0.4	0.4
Novel to familiar place preference ratio	0.2	0.2	0.5	-0.2	-0.3	0.0	-0.4	0.7	-0.6
Novelty place preference	0.0	0.0	0.1	-0.2	-0.1	0.0	-0.2	0.3	-0.3
Time in novel zone, NPP test	0.1	0.1	0.1	0.0	0.2	0.2	0.1	0.4	-0.3
Total zone transitions, NPP test	1.5	2.1	3.1	1.8	1.2	1.6	0.9	1.5	-1.6
Total locomotion distance, NPP test	0.4	0.6	1.5	0.8	0.3	0.5	-0.0	1.1	-1.2
Locomotion velocity, NPP test	0.3	0.5	1.4	0.4	-0.2	0.2	-0.6	1.0	-1.2
Intraocular pressure	1.6	2.3	5.8	1.2	0.1	1.0	-0.7	2.4	-2.3
Delta distance traveled before/after self-admin	1.5	1.6	3.3	1.1	1.8	1.3	1.8	0.5	-0.4
Delta ambulatory time before/after self-admin	1.1	1.4	2.8	1.1	1.6	1.2	1.7	0.4	-0.3
Parametrial fat weight	5.3	12.5	22.5	4.0	4.6	3.8	4.7	1.1	-0.4
Pavlov. Cond. lever latency	0.3	0.3	0.8	0.6	0.2	0.6	-0.1	0.9	-0.7
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	-0.2	0.3	-0.1	0.6	-0.9	1.0
Pavlov. Cond. change in total contacts	0.5	0.6	1.0	-0.7	-0.8	-1.0	-0.7	-0.7	0.6
Pavlov. Cond. index score	0.4	0.5	1.1	-0.3	0.3	-0.2	0.7	-1.0	1.0
Pavlov. Cond. latency score	0.5	0.7	1.6	-0.5	0.3	-0.4	0.7	-1.3	1.2
Pavlov. Cond. lever contacts	0.3	0.3	0.7	-0.6	-0.1	-0.5	0.1	-0.8	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.1	-0.2	-0.0	-0.3	0.3	-0.4
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.3	1.1	0.4	0.9	-0.1	1.5	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	-0.3	0.3	-0.2	0.6	-0.9	0.9
Pavlov. Cond. response bias	0.1	0.2	0.4	0.1	0.3	-0.0	0.5	-0.5	0.7
Pavlov. Cond. lever latency	0.6	0.8	2.1	0.6	1.3	0.8	1.5	-0.1	0.2
Pavlov. Cond. magazine entry latency	1.2	1.4	1.7	-1.2	-1.2	-1.3	-0.9	-1.3	1.3
Pavlov. Cond. change in total contacts	0.5	0.8	1.3	-1.1	-1.1	-1.0	-1.1	-0.4	0.2
Pavlov. Cond. index score	0.9	1.2	2.7	-1.0	-1.5	-1.1	-1.6	-0.2	0.1
Pavlov. Cond. latency score	1.1	1.4	3.3	-1.1	-1.7	-1.2	-1.8	-0.2	0.1
Pavlov. Cond. lever contacts	0.3	0.4	1.0	-0.5	-0.9	-0.6	-1.0	-0.1	0.0
Pavlov. Cond. magazine entry number	1.2	1.5	1.8	1.3	1.3	1.3	1.1	1.1	-1.1
Pavlov. Cond. intertrial magazine entries	1.9	2.9	3.3	1.8	1.8	1.7	1.5	1.7	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.1	2.6	-0.9	-1.5	-1.0	-1.6	-0.2	0.1
Pavlov. Cond. response bias	0.5	0.7	1.4	-0.8	-1.2	-0.9	-1.2	-0.5	0.4
Time in closed arm before self-admin	0.7	0.9	2.3	0.2	1.1	0.7	1.5	-0.8	0.9
Time in closed arm after self-admin	0.6	0.7	1.1	-0.8	-0.6	-0.9	-0.4	-1.0	1.0
Time in open arm before self-admin	2.1	2.3	4.7	-1.3	-2.0	-1.8	-2.2	-0.2	0.0
Time in open arm after self-admin	0.6	0.6	1.4	0.2	-0.7	-0.2	-0.9	0.9	-1.2
Bone: periosteal estimation	0.2	0.3	0.7	-0.8	-0.6	-0.8	-0.6	-0.0	-0.1
Bone: periosteal perimeter	0.2	0.3	0.8	0.0	-0.0	0.0	-0.2	0.9	-0.9
Bone: post-yield work	0.2	0.4	0.9	0.5	0.8	0.4	0.9	-0.3	0.3
Progressive ratio test 1 active lever presses	0.5	0.6	1.5	0.8	0.5	0.2	0.1	1.2	-1.2
Progressive ratio test 1 breakpoint	0.6	0.7	1.7	0.9	0.5	0.3	0.1	1.3	-1.3
Progressive ratio test 1 inactive lever presses	0.5	0.7	1.5	-0.7	-1.0	-1.1	-1.2	0.3	-0.5
Progressive ratio test 2 active lever presses	2.9	3.4	5.9	2.2	1.5	1.1	0.8	2.4	-2.4
Progressive ratio test 2 breakpoint	3.0	3.5	5.9	2.2	1.5	1.2	0.9	2.4	-2.4
Progressive ratio test 2 inactive lever presses	1.0	1.6	3.9	1.3	0.6	0.3	0.0	1.9	-2.0
Incentive Sensitization - Responses	2.4	3.5	5.5	2.2	1.7	1.2	1.0	2.3	-2.3
Incentive Sensitization - Breakpoint	2.3	3.0	4.6	2.0	1.6	1.1	1.0	2.1	-2.1
Sum of active levers in priming session hrs 5-6	2.5	2.3	4.3	1.7	2.0	1.3	2.1	0.8	-0.6
Progressive ratio	0.1	0.1	0.3	-0.2	-0.1	0.2	-0.3	0.3	-0.5
Food seeking constrained by brief footshock	0.1	0.1	0.2	-0.3	-0.3	-0.4	-0.3	-0.2	0.3
Seeking ratio, punishment vs. effort	0.7	1.0	1.7	-0.8	-0.8	-1.3	-0.6	-1.0	1.2
Retroperitoneal fat weight	0.4	1.6	4.4	2.1	1.2	1.2	1.0	0.9	-0.7
Reaction time number correct	0.0	0.1	0.2	-0.0	0.4	0.2	0.4	0.2	-0.2
Reaction time mean minus median	0.0	0.1	0.3	0.1	-0.4	0.2	-0.6	0.3	-0.3
Reaction time mean minus median AUC	0.4	0.9	1.4	1.0	0.6	1.2	0.3	1.2	-1.1
Reaction time num false alarms	0.8	1.2	3.0	0.7	-0.0	0.9	-0.5	1.6	-1.7
Reaction time num false alarms AUC	0.6	0.9	2.5	0.5	-0.1	0.8	-0.5	1.4	-1.6
Reaction time trials correct on left	0.0	0.1	0.2	-0.0	0.4	0.2	0.4	0.2	-0.2
Reaction time trials on left	0.0	0.1	0.1	0.0	0.3	0.2	0.4	0.2	-0.2
Reaction time mean	0.1	0.1	0.2	-0.1	-0.4	-0.2	-0.5	-0.3	0.2
Reaction time mean AUC	0.1	0.2	0.6	-0.3	-0.7	-0.3	-0.8	-0.1	0.0
Median of all reaction times	0.1	0.2	0.2	-0.3	-0.5	-0.4	-0.5	-0.5	0.4
Reaction time omissions	0.0	0.0	0.1	0.1	0.0	0.3	0.1	-0.0	0.2
Reaction time false alarm rate	0.5	0.6	1.7	0.4	-0.1	0.7	-0.5	1.1	-1.3
Reaction time premature initiation rate	0.7	0.9	1.5	1.2	1.1	0.9	0.9	0.8	-0.6
Reaction time premature initiations	0.6	1.1	1.5	1.2	1.2	1.1	1.1	0.9	-0.8
Std. dev. reaction times	0.1	0.1	0.3	-0.3	-0.5	0.1	-0.6	0.1	-0.1
Reaction time trials completed	0.0	0.1	0.1	0.0	0.3	0.2	0.4	0.2	-0.2
Reaction time trials AUC	0.0	0.1	0.1	-0.1	0.3	0.2	0.3	0.3	-0.3
Run reversals in cocaine runway, females	0.2	0.2	0.4	0.2	-0.0	0.3	-0.3	0.6	-0.6
Run reversals in cocaine runway, males	1.2	1.2	2.6	1.2	0.4	0.9	-0.0	1.5	-1.6
Latency to leave start box in cocaine runway	0.4	0.5	0.8	-0.9	-0.5	-0.6	-0.3	-0.8	0.9
Latency to leave start box in cocaine runway, F	1.1	1.3	2.9	-1.3	-0.4	-0.8	0.1	-1.6	1.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.3	-0.0	0.1	-0.2	0.5	-0.6
Std. dev. time between licks in bursts	0.2	0.3	0.5	0.7	0.5	0.6	0.4	0.5	-0.6
Total sessions with >9 infusions	0.9	1.1	2.4	1.0	0.7	0.5	0.3	1.5	-1.5
Short access day 1 total inactive lever presses	0.1	0.1	0.2	0.3	0.4	0.2	0.3	0.5	-0.4
Short access day 10 total inactive lever presses	0.3	0.8	1.3	-1.0	-1.1	-1.0	-1.1	-0.2	-0.0
Short access day 1 total infusions	0.4	0.5	1.5	0.0	-0.2	-0.2	-0.6	1.2	-1.2
Short access day 10 total infusions	1.2	1.5	4.0	1.0	0.3	0.5	-0.2	1.9	-2.0
Short access total infusions	0.4	0.5	1.3	0.4	-0.1	-0.1	-0.5	1.1	-1.2
Short access day 1 locomotion	0.5	0.7	1.0	-0.6	-0.7	-0.9	-1.0	0.8	-0.9
Short access day 10 total locomotion	0.3	0.5	0.8	-0.6	-0.7	-0.7	-0.9	0.6	-0.7
Short access total locomotion	0.8	0.9	1.6	-0.7	-0.9	-1.0	-1.3	0.9	-1.0
One hour access (0.3 mA shock)	2.3	2.6	3.6	1.9	1.4	1.6	0.9	1.9	-1.8
Compulsive drug intake	0.7	0.8	1.7	0.2	0.7	0.1	1.1	-1.1	1.3
One hour access (shock baseline)	0.6	1.0	2.5	0.8	0.3	0.6	-0.1	1.5	-1.6
Social response proportion	1.5	1.7	3.9	0.2	1.4	0.5	2.0	-1.2	1.5
Social responses	1.0	1.3	3.2	0.9	1.5	1.2	1.8	-0.2	0.3
Social time	1.1	1.5	3.2	0.9	1.5	1.5	1.8	-0.4	0.8
Soleus weight	2.2	6.5	13.9	2.4	3.5	2.6	3.7	0.4	0.2
Bone: stiffness	0.4	0.7	1.9	0.3	1.0	0.4	1.4	-0.6	0.8
Tibialis anterior weight	7.4	25.1	33.9	5.5	5.6	5.8	5.0	4.1	-3.6
Time to tail flick, vehicle, before self-admin	5.1	5.3	7.8	2.4	2.8	2.8	2.6	1.5	-1.2
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.4	0.4	0.6	0.5	0.6	0.1	0.0
Time to tail flick, test, before self-admin	0.8	0.9	2.4	-0.6	0.3	0.4	0.7	-1.3	1.5
Time to tail flick, test, after self-admin	0.4	0.4	0.9	-0.5	-0.4	-0.7	-0.2	-1.0	0.8
Delta time to tail flick, vehicle, before/after SA	1.3	1.2	2.2	-1.3	-1.5	-1.0	-1.5	-0.5	0.3
Delta time to tail flick, test, before/after SA	0.7	0.7	2.0	0.8	-0.2	-0.2	-0.6	1.1	-1.4
Tibia length	1.0	2.9	6.8	-1.4	-0.5	-1.2	0.2	-2.6	2.6
Ambulatory time before self-admin	2.6	3.8	5.7	-1.9	-2.4	-2.3	-2.3	-1.3	1.1
Ambulatory time after self-admin	0.5	0.6	1.1	-0.8	-0.4	-0.9	-0.2	-1.1	1.1
Bone: tissue strength	2.4	2.4	3.5	-1.9	-1.6	-1.7	-1.3	-1.4	1.3
Total heroin consumption	4.6	5.4	9.4	2.6	3.0	2.4	3.1	0.9	-0.6
Bone: trabecular number	4.4	7.3	11.0	3.3	3.1	3.1	2.9	1.7	-1.5
Bone: trabecular spacing	0.4	0.5	0.9	-0.9	-0.9	-0.7	-0.9	0.1	-0.2
Bone: trabecular thickness	0.3	0.3	0.6	0.5	0.7	0.7	0.7	0.0	-0.1
Bone: trabecular tissue density	1.8	2.7	4.0	-1.6	-2.0	-2.0	-1.9	-1.1	0.8
Water consumed over 24 hours	1.2	1.6	3.5	-1.3	-0.7	-1.2	-0.2	-1.7	1.9
Number of responses in last shaping day	0.9	1.0	1.9	-0.3	-1.1	-0.7	-1.4	0.9	-1.1