Ripply3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Ripply3	0.06	0.03	6.1e-07	0.05	0.04	0.04	0.04	2.3e-06	8.7e-06	8.7e-06	1.0e-05
2	NAcc	gene expression	Ripply3	0.04	0.03	2.4e-05	0.05	0.04	0.03	0.04	3.0e-06	1.8e-05	1.3e-04	3.3e-05
3	Brain	gene expression	Ripply3	0.04	0.03	1.8e-04	0.03	0.04	0.04	0.03	9.9e-04	1.5e-04	3.1e-04	8.2e-04
4	PL	gene expression	Ripply3	0.06	0.04	3.8e-07	0.06	0.06	0.05	0.06	1.1e-07	8.8e-07	1.8e-06	8.7e-07
5	BLA	gene expression	Ripply3	0.1	0.06	4.8e-04	0.02	0.04	0.05	0.02	3.3e-02	4.3e-03	1.1e-03	3.6e-02
6	Eye	gene expression	Ripply3	0.67	0.14	1.6e-04	0.03	0.07	0.05	0.04	1.2e-01	2.8e-02	5.8e-02	8.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.2	0.3	1.0	-0.1	-0.1	0.6	-0.5	-1.0	0.6
Area under the delay curve	1.7	1.8	4.7	-0.3	-0.3	1.3	-1.3	-1.7	2.2
BMI with tail	0.3	0.9	2.8	1.0	0.9	-0.1	0.1	-1.0	1.7
BMI without tail	0.1	0.1	0.4	-0.1	0.1	0.3	-0.3	-0.6	0.5
Body weight	0.1	0.5	1.1	0.9	0.8	-0.2	0.1	-0.6	1.0
Weight adjusted by age	0.8	0.9	1.8	-1.1	-1.2	1.0	-1.3	-0.4	0.0
Bone surface	2.0	3.5	6.1	2.5	2.5	-1.9	2.0	0.2	1.0
Bone volume	1.0	1.8	3.6	1.9	1.9	-1.2	1.1	-0.2	0.9
Breakpoint value in progressive ratio session	0.1	0.1	0.3	-0.2	-0.2	-0.1	-0.0	0.5	0.0
Number of licking bursts	0.8	0.9	1.5	-0.6	-0.6	1.2	-1.2	-1.2	0.6
Context. condit. distance diff. score	0.1	0.1	0.3	-0.5	-0.4	0.0	-0.2	0.6	0.2
Locomotion velocity, session 1	0.1	0.1	0.3	0.1	0.0	-0.3	0.4	0.4	-0.5
Locomotion distance, session 1	0.4	0.5	1.2	0.2	0.2	-0.8	1.1	0.9	-0.2
Locomotion velocity, session 2	0.2	0.3	0.7	0.0	-0.1	-0.6	0.6	0.9	-0.5
Locomotion distance, session 2	0.2	0.2	0.5	-0.4	-0.5	0.5	-0.3	-0.4	0.7
Locomotion velocity, session 3	4.5	5.2	9.1	1.9	1.9	-2.8	3.0	2.3	-1.4
Locomotion distance, session 3	0.4	0.4	1.0	0.7	0.7	-0.5	1.0	-0.3	0.4
Stereotopy head waving bouts, day 3	1.9	2.3	5.1	0.9	0.9	-1.5	1.8	1.2	-2.3
Stereotopy head waving duration, day 3	1.6	2.0	4.0	1.0	1.0	-1.5	1.5	1.2	-2.0
Locomotion velocity, session 7	1.0	1.1	2.2	-1.5	-1.5	1.1	-1.0	-0.2	-0.2
Locomotion distance, session 7	2.5	3.2	4.4	-2.1	-2.1	2.1	-1.6	-1.4	1.2
Stereotopy head waving bouts, day 7	4.1	4.6	6.0	1.5	1.5	-2.4	2.3	2.5	-2.4
Stereotopy head waving duration, day 7	4.0	4.9	7.6	1.6	1.6	-2.6	2.3	2.7	-2.1
Locomotion velocity, session 8	3.2	3.8	5.8	1.7	1.7	-2.4	2.4	2.0	-1.3
Locomotion distance, session 8	0.2	0.2	0.4	-0.6	-0.6	0.2	-0.2	0.2	0.7
Degree of sensitization distance	2.1	2.2	3.8	-2.0	-1.9	1.6	-1.5	-0.5	0.3
Degree of sensitization stereotypy	3.4	3.7	5.6	1.8	1.8	-2.4	2.1	2.1	-1.2
Conditioned locomotion	0.4	0.5	1.0	-1.0	-1.0	0.7	-0.8	0.0	-0.3
Cocaine response after cond. corrected	0.5	0.5	1.5	-0.5	-0.6	-0.4	0.3	1.2	-1.0
Cocaine response after cond. not corrected	0.5	0.6	1.2	-0.9	-1.0	-0.0	0.1	1.1	-0.7
Cocaine response before conditioning	0.2	0.2	0.4	-0.4	-0.4	0.5	-0.3	-0.3	0.7
Saline control response	0.6	0.7	1.2	0.6	0.6	-1.1	1.1	1.0	-0.5
Bone: connectivity density	0.3	0.4	0.7	0.8	0.8	-0.3	0.4	-0.6	0.8
Bone: cortical apparent density	0.1	0.1	0.2	0.1	0.1	0.2	-0.3	-0.5	0.5
Bone: cortical area	0.2	0.3	1.1	0.1	0.1	-0.6	0.4	1.0	-0.5
Bone: cortical porosity	0.3	0.3	0.6	-0.7	-0.7	0.7	-0.8	-0.3	-0.0
Bone: cortical porosity	0.5	0.5	0.8	-0.8	-0.8	0.9	-0.9	-0.5	0.4
Bone: cortical thickness	1.2	1.9	3.3	-1.8	-1.8	0.9	-1.2	1.0	-1.3
Bone: cortical thickness	0.4	0.5	1.1	-0.7	-0.7	0.8	-1.1	-0.3	0.1
Bone: cortical tissue density	0.1	0.1	0.3	0.2	0.2	0.2	-0.3	-0.5	0.5
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.1	-0.0	-0.0	-0.0	0.1	-0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.6	-0.5	0.1	-0.1	0.5	-0.6
Condit. Reinf. active responses	0.0	0.0	0.0	0.0	0.1	-0.1	-0.0	0.1	0.2
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	0.2	-0.0
Incentive salience index mean	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.4	-0.1	0.1
Condit. Reinf. lever presses	0.2	0.3	0.6	-0.7	-0.7	0.5	-0.8	0.1	0.0
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	0.4	0.4	-0.5	0.4	0.4	0.7
Condit. Reinf. active-inactive response ratio	0.6	0.7	2.4	-0.0	-0.0	0.5	-0.6	-0.9	1.5
Condit. Reinf. active responses	1.0	1.4	2.3	0.8	0.8	-1.5	1.5	1.5	-0.7
Condit. Reinf. inactive responses	2.0	2.4	4.1	0.7	0.7	-1.7	1.9	2.0	-1.6
Condit. Reinf. lever presses	0.5	0.7	1.1	0.8	0.8	-1.1	0.9	1.0	-0.3
Condit. Reinf. lever reinforcers received	1.0	1.4	2.4	0.9	0.9	-1.5	1.5	1.4	-0.5
Conditioned reinforcement - actives	0.6	0.6	1.0	-0.6	-0.7	0.8	-0.9	-0.5	1.0
Conditioned reinforcement - inactives	1.4	1.6	3.4	-1.8	-1.8	0.7	-0.7	0.9	-1.0
Conditioned locomotion	0.2	0.2	0.4	-0.6	-0.6	0.4	-0.3	0.0	-0.3
Patch foraging indifference point 0 sec	1.5	2.4	5.3	-1.6	-1.6	0.1	-0.4	1.9	-2.3
Patch foraging indifference point AUC	1.8	2.1	3.1	1.1	1.1	-1.8	1.7	1.7	-1.0
Delay disc. indifference point, 0s delay	0.8	0.9	3.2	0.3	0.2	0.5	-0.7	-1.2	1.8
Delay disc. indifference point, 16s delay	0.6	0.6	1.6	-0.0	-0.0	0.8	-0.6	-1.3	1.1
Delay disc. indifference point, 2s delay	1.0	1.2	3.6	0.3	0.2	0.7	-0.8	-1.5	1.9
Delay disc. indifference point, 24s delay	1.4	1.4	2.1	-1.0	-1.0	1.4	-1.5	-1.0	1.1
Delay disc. indifference point, 4s delay	1.1	1.2	3.7	0.0	0.0	0.8	-0.9	-1.3	1.9
Delay disc. indifference point, 8s delay	1.1	1.2	1.8	-0.8	-0.8	1.2	-1.3	-1.0	1.3
Indifference point function ln k	0.8	1.1	2.0	-1.3	-1.3	1.2	-1.4	-0.4	0.0
Indifference point function log k	0.8	1.1	2.0	-1.3	-1.3	1.2	-1.4	-0.4	0.0
Patch foraging total patch changes 0 sec	1.2	2.0	4.7	-1.3	-1.3	-0.1	-0.2	2.0	-2.2
Patch foraging total patch changes 12 sec	2.0	2.6	4.7	0.9	0.8	-1.8	1.6	2.2	-1.9
Patch foraging total patch changes 18 sec	1.5	1.9	4.6	0.4	0.5	-1.5	1.2	2.2	-1.6
Patch foraging total patch changes 24 sec	0.6	0.7	1.7	0.6	0.6	-1.1	0.7	1.3	-0.4
Patch foraging total patch changes 6 sec	2.4	3.5	7.6	0.2	0.1	-1.8	1.8	2.8	-2.7
Patch foraging time to switch 0 sec	0.4	0.6	2.0	-0.1	0.0	0.7	-0.3	-1.4	1.2
Patch foraging water rate 0 sec	1.9	3.0	4.1	1.5	1.4	-2.0	1.7	2.0	-1.6
Patch foraging water rate 12 sec	1.1	1.6	3.6	-1.8	-1.9	0.9	-1.0	0.7	-0.9
Patch foraging water rate 18 sec	0.3	0.4	0.9	0.9	0.9	-0.3	0.2	-0.3	0.5
Patch foraging water rate 24 sec	0.4	0.5	1.0	-0.7	-0.8	0.7	-1.0	-0.0	0.6
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.3	-0.4	0.2	-0.4	0.4	-0.0
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	2.1	-0.1	-0.1	1.0	-1.2	-1.5	0.8
Distance traveled before self-admin	0.1	0.1	0.1	0.2	0.2	-0.3	0.2	0.3	0.2
Distance traveled after self-admin	0.7	0.8	2.1	0.4	0.4	0.6	-0.6	-1.5	1.4
Extensor digitorum longus weight	3.0	11.8	21.8	4.7	4.6	-3.7	3.7	0.6	0.3
Bone: elastic displacement	0.3	0.3	0.5	-0.6	-0.6	0.6	-0.7	-0.4	-0.2
Bone: elastic work	0.1	0.1	0.6	0.0	0.0	-0.3	0.1	0.4	-0.7
Bone: endosteal estimation	2.1	4.6	8.3	2.9	2.9	-1.7	2.0	-0.7	1.9
Bone: endosteal perimeter	1.0	2.2	3.4	1.7	1.7	-1.6	1.8	0.5	0.8
Epididymis fat weight	2.4	5.7	11.7	3.4	3.1	-2.3	2.1	-0.0	1.8
Delta time in closed arm before/after self-admin	0.9	0.9	2.4	0.0	0.0	0.8	-0.7	-1.5	1.4
Delta time in open arm before/after self-admin	0.3	0.3	0.6	0.8	0.8	-0.6	0.5	0.2	0.0
Diff in mean of infusions in LGA sessions	2.2	2.4	5.5	0.5	0.5	-1.8	1.7	2.3	-1.5
Delay discount exponential model param	1.6	1.7	4.2	0.4	0.4	-1.3	1.3	1.5	-2.1
Extinction: sum of active levers before priming	0.8	0.8	2.2	0.3	0.3	-1.0	0.8	1.5	-0.7
Active lever presses in extinction session 6	2.4	2.3	7.6	-0.5	-0.5	-0.9	1.1	1.9	-2.7
Bone: final force	0.4	0.6	0.9	0.8	0.8	-0.9	0.9	0.7	-0.3
Bone: final moment	0.4	0.6	1.0	0.8	0.8	-1.0	0.9	0.8	-0.4
Food consumed during 24 hour testing period	0.4	0.5	0.9	-1.0	-1.0	0.3	-0.4	0.6	-0.8
Glucose	3.9	5.8	9.0	2.6	2.6	-2.9	3.0	1.7	-0.9
Heart weight	1.1	1.5	3.2	1.4	1.3	0.2	-0.2	-1.8	1.5
Delay discount hyperbolic model param	1.6	1.7	4.4	0.2	0.2	-1.2	1.3	1.6	-2.1
Intermittent access intake day 1-15 change	0.7	0.7	1.6	-1.0	-0.9	0.1	-0.2	0.9	-1.3
Intermittent access intake escalation	0.7	0.7	2.0	-0.9	-0.8	-0.0	-0.0	1.0	-1.4
Intermittent access intake escalation 2	1.4	1.4	3.5	-0.8	-0.7	-0.7	0.8	1.7	-1.9
Intermitt. access day 1 inactive lever presses	1.8	1.9	4.5	-2.1	-1.9	1.1	-0.9	0.4	-1.0
Intermitt. access day 15 inactive lever presses	0.6	0.7	1.5	-1.0	-0.8	0.0	-0.1	1.2	-0.8
Intermitt. access escalation Index	0.1	0.1	0.3	-0.1	-0.3	0.2	-0.5	0.2	-0.3
Intermittent access day 1 total infusions	0.4	0.5	1.0	-1.0	-0.9	0.6	-0.8	0.4	0.1
Intermittent access day 15 total infusions	2.0	2.3	3.8	-2.0	-1.9	0.4	-0.3	1.6	-1.9
Intermittent access terminal intake (last 3 days)	1.7	1.8	3.5	-1.9	-1.8	0.6	-0.6	1.2	-1.4
Intermittent access total infusions	1.2	1.4	2.7	-1.7	-1.6	0.5	-0.6	1.1	-1.1
Intermittent access day 1 locomotion	1.6	1.7	3.1	-1.8	-1.7	1.4	-1.6	0.0	0.2
Intermittent access day 15 total locomotion	1.2	1.3	3.1	-1.1	-1.0	-0.3	0.2	1.8	-1.5
Intermittent access total locomotion	1.9	2.1	3.9	-2.0	-1.9	0.4	-0.5	1.7	-1.4
Intermittent access standard deviation	1.0	1.1	3.2	-0.9	-0.9	-0.3	0.6	1.2	-1.8
Left kidney weight	2.2	6.1	9.9	-2.0	-2.2	2.8	-3.2	-2.2	2.2
Right kidney weight	2.1	5.9	8.7	-2.5	-2.7	2.8	-3.0	-1.6	1.6
Cocaine induced anxiety	0.3	0.3	1.0	-0.2	-0.2	-0.4	0.4	1.0	-0.7
Post-drug Anxiety	0.9	1.1	2.6	0.3	0.3	-1.2	1.2	1.6	-0.8
Baseline Anxiety	0.0	0.0	0.1	-0.0	-0.0	-0.1	0.3	-0.0	0.0
Tail length	0.4	1.1	2.0	-1.4	-1.4	0.6	-0.8	0.8	-1.2
Length with tail	0.0	0.1	0.3	-0.3	-0.4	0.3	-0.5	0.3	-0.4
Length without tail	0.0	0.0	0.1	0.3	0.0	-0.1	0.0	0.1	0.2
Times rat made contact with spout	5.2	6.0	11.9	-3.4	-3.4	2.3	-2.3	0.1	-1.3
Lifetime Intake	0.5	0.5	1.1	-1.0	-1.1	0.6	-0.6	0.4	-0.4
Liver weight, left	0.1	0.2	0.6	-0.5	-0.6	0.4	-0.8	0.1	0.0
Liver weight, right	0.2	0.3	0.5	-0.5	-0.5	0.7	-0.4	-0.7	0.6
Locomotor activity	2.8	4.4	8.0	-2.7	-2.8	2.3	-2.3	-0.7	0.4
Locomotor testing distance	1.2	1.9	4.4	-2.0	-2.1	1.2	-1.1	0.3	-0.7
Locomotor testing rearing	0.8	1.2	1.7	-1.2	-1.3	1.3	-1.3	-0.6	0.7
Locomotion in novel chamber	0.2	0.2	0.6	-0.5	-0.5	-0.0	-0.2	0.6	-0.8
Locomotion in novel chamber post-restriction	1.0	1.2	2.6	1.6	1.6	-0.9	0.8	-0.5	0.4
Fecal boli incidents, locomotor time 1	1.1	1.2	2.7	-0.6	-0.6	1.0	-1.4	-0.9	1.6
Change in fecal boli incidents, locomotor task	1.7	1.6	2.9	-1.6	-1.7	1.4	-1.3	-0.5	-0.1
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.5	-0.6	-0.5	-0.0	-0.1	1.0	-1.2
Bouts of movement, locomotor time 1	0.2	0.2	0.2	0.3	0.3	-0.5	0.4	0.5	-0.5
Total resting periods, locomotor time 1	0.1	0.1	0.3	0.1	0.2	-0.4	0.3	0.5	-0.4
Rest time, locomotor task time 1	0.9	1.0	4.3	0.3	0.3	0.4	-0.4	-1.2	2.1
Distance moved, locomotor task time 1	0.3	0.3	1.7	-0.2	-0.2	0.1	-0.1	0.1	-1.3
Vertical activity count, locomotor time 1	0.9	1.0	3.1	0.3	0.2	-0.8	0.8	1.1	-1.8
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.0	0.9	1.0	-0.5	0.5	-0.3	-0.0
Bouts of movement, locomotor time 2	1.2	1.3	2.0	1.4	1.3	-1.3	1.2	0.9	0.4
Total resting periods, locomotor time 2	0.4	0.4	0.7	0.7	0.6	-0.8	0.6	0.8	0.4
Rest time, locomotor task time 2	0.4	0.4	1.0	-1.0	-1.0	0.3	-0.4	0.6	-0.1
Distance moved, locomotor task time 2	0.5	0.6	1.1	1.0	1.1	-0.2	0.4	-1.0	0.1
Vertical activity count, locomotor time 2	0.7	0.8	1.8	1.3	1.3	-0.6	0.6	-0.5	0.2
Light reinforcement 1	0.3	0.5	1.6	0.1	0.2	0.5	-0.5	-0.9	1.3
Light reinforcement 2	2.4	3.1	6.3	2.4	2.5	-1.8	1.6	0.3	1.0
Bone: marrow area	2.1	4.6	8.3	2.9	2.9	-1.7	2.0	-0.7	1.9
Bone: maximum diameter	0.7	1.4	2.1	1.3	1.3	-1.5	1.3	1.1	-0.1
Bone: maximum force	0.4	0.7	1.0	0.9	0.9	-1.0	1.0	0.6	-0.4
Bone: maximum moment	0.3	0.6	0.9	0.9	0.9	-0.9	0.8	0.6	-0.4
Mean time between licks in bursts	1.7	2.4	4.2	-2.1	-2.1	1.8	-1.5	-0.9	-0.1
Mean num. licks in bursts	1.1	1.3	2.9	-1.1	-1.1	-0.2	0.2	1.6	-1.7
Cd content in liver	0.8	0.9	1.5	-1.2	-1.2	0.7	-0.6	0.1	-1.1
Co content in liver	0.1	0.1	0.3	0.2	0.2	0.1	-0.2	-0.4	0.5
Cu content in liver	0.1	0.1	0.3	0.2	0.3	-0.3	0.3	0.3	-0.5
Fe content in liver	1.7	2.1	5.2	0.8	0.8	-1.4	1.3	1.5	-2.3
K content in liver	0.5	0.5	1.0	1.0	1.0	-0.3	0.4	-0.6	0.5
Mg content in liver	0.6	0.6	1.4	1.2	1.1	-0.7	0.7	-0.2	-0.1
Mn content in liver	0.7	0.8	1.7	1.1	1.0	-0.4	0.5	-0.5	1.3
Na content in liver	3.4	3.5	5.4	2.0	2.0	-2.3	2.3	1.5	-0.7
Rb content in liver	0.5	0.6	1.4	-0.5	-0.6	0.9	-1.2	-0.7	0.3
Se content in liver	0.6	0.7	3.5	-0.4	-0.3	-0.3	0.3	0.8	-1.9
Sr content in liver	1.9	1.8	2.6	-1.6	-1.6	1.6	-1.6	-0.6	0.3
Zn content in liver	0.5	0.5	1.4	-0.6	-0.6	-0.2	0.1	1.0	-1.2
Bone: minimum diameter	3.0	5.5	8.4	2.9	2.9	-2.7	2.9	1.0	0.1
Time in familiar zone, hab. session 1	0.1	0.1	0.4	-0.3	-0.3	0.3	-0.1	-0.1	0.7
Time in novel zone, hab. session 1	0.5	0.5	1.1	1.0	1.1	-0.4	0.5	-0.6	-0.1
Total zone transitions, hab. session 1	1.3	1.9	3.8	-1.9	-2.0	1.4	-1.3	-0.3	0.4
Total locomotion distance, hab. session 1	1.3	1.8	3.2	-1.8	-1.8	1.5	-1.4	-0.5	0.3
Locomotion velocity, hab. session 1	1.4	2.0	3.6	-1.9	-1.9	1.6	-1.5	-0.6	0.3
Time in familiar zone, hab. session 2	0.5	0.5	2.2	0.5	0.5	-0.0	0.1	-0.6	1.5
Time in novel zone, hab. session 2	0.2	0.2	0.7	-0.2	-0.2	0.1	-0.3	0.0	-0.9
Total zone transitions, hab. session 2	1.4	1.8	2.4	-1.5	-1.5	1.4	-1.2	-0.8	1.5
Total locomotion distance, hab. session 2	3.0	4.0	5.3	-2.1	-2.1	2.3	-2.1	-1.5	1.6
Locomotion velocity, hab. session 2	2.9	3.9	5.2	-2.2	-2.2	2.3	-2.0	-1.5	1.6
Novel to familiar place preference ratio	0.2	0.2	0.8	-0.1	-0.1	0.5	-0.1	-0.9	0.2
Novelty place preference	0.3	0.3	1.2	0.3	0.3	0.3	-0.0	-1.1	0.5
Time in novel zone, NPP test	0.3	0.3	1.2	0.5	0.5	0.2	0.1	-1.1	0.6
Total zone transitions, NPP test	0.1	0.2	0.4	-0.5	-0.6	0.1	-0.2	0.3	0.3
Total locomotion distance, NPP test	0.5	0.7	0.9	-0.8	-0.8	0.9	-0.8	-0.8	0.7
Locomotion velocity, NPP test	0.6	0.9	1.2	-1.0	-1.1	1.1	-1.0	-0.8	0.7
Intraocular pressure	0.2	0.3	0.8	0.6	0.6	0.1	-0.1	-0.9	0.3
Delta distance traveled before/after self-admin	1.5	1.6	3.5	-0.3	-0.3	1.3	-1.2	-1.9	1.7
Delta ambulatory time before/after self-admin	1.7	1.8	3.6	-0.4	-0.4	1.4	-1.3	-1.9	1.9
Parametrial fat weight	1.0	1.9	3.5	1.7	1.6	-0.5	0.5	-1.2	1.9
Pavlov. Cond. lever latency	0.2	0.2	0.4	-0.3	-0.2	0.5	-0.3	-0.6	0.5
Pavlov. Cond. magazine entry latency	0.4	0.6	0.9	-0.8	-0.8	0.9	-0.9	-0.6	0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.2	-0.1	-0.1	0.2	-0.4	0.0	0.1
Pavlov. Cond. index score	0.0	0.1	0.1	-0.3	-0.4	0.2	-0.3	0.0	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.5	-0.1	-0.1
Pavlov. Cond. lever contacts	0.3	0.3	0.9	-0.3	-0.3	-0.3	0.1	1.0	-0.8
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.2	0.3	-0.4	0.4	0.4	-0.0
Pavlov. Cond. intertrial magazine entries	6.2	7.6	10.7	2.6	2.6	-3.3	3.0	2.6	-2.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.2	-0.3	0.2	-0.3	0.0	-0.2
Pavlov. Cond. response bias	0.1	0.2	0.3	-0.5	-0.6	0.3	-0.4	0.2	-0.3
Pavlov. Cond. lever latency	1.2	1.6	2.6	-1.3	-1.3	1.6	-1.4	-1.3	0.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.6	-0.2	-0.2	-0.2	-0.0	0.8	-0.2
Pavlov. Cond. change in total contacts	0.4	0.6	0.9	1.0	1.0	-0.9	0.6	0.4	0.5
Pavlov. Cond. index score	0.6	0.7	2.0	0.4	0.4	-1.0	0.7	1.4	-0.7
Pavlov. Cond. latency score	0.2	0.3	1.0	0.0	0.0	-0.5	0.2	1.0	-0.4
Pavlov. Cond. lever contacts	0.5	0.7	1.1	0.9	0.9	-1.0	0.8	0.8	0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.3	-0.3	0.2	-0.1	-0.1	-0.4
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	0.4	0.4	-0.8	0.9	0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	1.8	0.2	0.2	-0.9	0.6	1.4	-0.6
Pavlov. Cond. response bias	0.4	0.6	0.9	0.8	0.8	-1.0	0.7	0.9	-0.0
Time in closed arm before self-admin	0.2	0.3	0.6	0.7	0.7	-0.3	0.1	-0.2	0.8
Time in closed arm after self-admin	3.8	3.8	10.8	0.5	0.5	1.3	-1.3	-2.9	3.3
Time in open arm before self-admin	0.1	0.1	0.2	-0.4	-0.4	0.4	-0.3	-0.2	0.1
Time in open arm after self-admin	1.2	1.3	2.9	0.4	0.4	-1.2	1.2	1.7	-1.4
Bone: periosteal estimation	1.0	2.0	3.4	1.8	1.8	-1.5	1.5	0.3	0.6
Bone: periosteal perimeter	0.5	0.9	1.5	0.8	0.8	-1.2	1.2	1.0	-0.1
Bone: post-yield work	1.3	1.8	2.6	1.2	1.2	-1.6	1.5	1.3	-1.1
Progressive ratio test 1 active lever presses	0.8	0.8	1.6	-0.8	-0.8	1.1	-1.3	-0.6	0.7
Progressive ratio test 1 breakpoint	1.2	1.2	2.2	-1.0	-1.0	1.3	-1.5	-0.9	0.8
Progressive ratio test 1 inactive lever presses	0.6	0.6	1.2	-1.1	-1.1	0.7	-0.6	0.3	-0.7
Progressive ratio test 2 active lever presses	1.1	1.1	2.1	-1.4	-1.5	0.4	-0.2	1.0	-1.3
Progressive ratio test 2 breakpoint	1.1	1.2	2.3	-1.3	-1.4	0.2	-0.1	1.2	-1.5
Progressive ratio test 2 inactive lever presses	2.0	2.3	4.7	-1.6	-1.7	-0.0	-0.1	2.2	-1.9
Incentive Sensitization - Responses	1.3	1.3	2.9	-0.2	-0.4	-0.9	1.1	1.7	-1.6
Incentive Sensitization - Breakpoint	1.5	1.5	3.4	-0.3	-0.4	-0.9	1.1	1.8	-1.8
Sum of active levers in priming session hrs 5-6	1.4	1.4	3.3	0.1	0.1	-1.1	1.0	1.6	-1.8
Progressive ratio	0.1	0.2	0.3	0.3	0.3	-0.4	0.2	0.5	-0.6
Food seeking constrained by brief footshock	1.0	1.3	2.3	-1.5	-1.5	1.2	-1.1	-0.5	-0.4
Seeking ratio, punishment vs. effort	0.9	1.1	1.6	-1.3	-1.3	1.3	-1.0	-0.9	0.3
Retroperitoneal fat weight	1.2	3.8	7.5	2.7	2.6	-2.0	2.0	0.1	0.7
Reaction time number correct	0.1	0.2	0.5	0.2	0.1	-0.5	0.4	0.7	-0.5
Reaction time mean minus median	0.4	0.5	1.1	-0.7	-0.8	0.0	-0.4	0.8	-1.1
Reaction time mean minus median AUC	0.7	0.9	2.5	-0.0	-0.2	-0.8	0.3	1.6	-1.5
Reaction time num false alarms	2.0	2.7	4.3	-2.1	-2.1	1.9	-1.7	-0.8	-0.2
Reaction time num false alarms AUC	2.7	3.7	5.4	-2.3	-2.3	2.3	-2.1	-1.2	0.3
Reaction time trials correct on left	0.1	0.2	0.5	0.2	0.1	-0.5	0.4	0.7	-0.5
Reaction time trials on left	0.1	0.2	0.6	0.2	0.1	-0.5	0.4	0.7	-0.5
Reaction time mean	0.1	0.1	0.2	0.5	0.4	-0.1	0.1	-0.4	-0.1
Reaction time mean AUC	0.1	0.1	0.4	0.2	0.2	-0.3	0.2	0.1	-0.6
Median of all reaction times	0.3	0.4	1.0	0.8	0.8	-0.1	0.1	-1.0	0.5
Reaction time omissions	0.0	0.0	0.1	0.1	-0.0	0.0	0.1	-0.2	0.3
Reaction time false alarm rate	2.4	3.3	5.1	-2.1	-2.0	2.3	-2.1	-1.4	0.4
Reaction time premature initiation rate	0.6	0.8	1.8	1.3	1.2	-0.6	0.2	-0.3	1.0
Reaction time premature initiations	0.4	0.6	1.5	1.2	1.0	-0.9	0.6	0.4	0.3
Std. dev. reaction times	0.3	0.4	0.9	-0.8	-0.8	0.3	-0.4	0.4	-0.9
Reaction time trials completed	0.1	0.2	0.6	0.2	0.1	-0.5	0.4	0.7	-0.5
Reaction time trials AUC	0.2	0.3	0.5	0.5	0.3	-0.7	0.6	0.7	-0.4
Run reversals in cocaine runway, females	0.5	0.5	0.9	-0.7	-0.7	0.8	-1.0	-0.3	0.3
Run reversals in cocaine runway, males	0.4	0.4	1.6	-0.2	-0.2	-0.5	0.3	1.3	-0.7
Latency to leave start box in cocaine runway	0.3	0.3	0.6	0.1	0.1	0.5	-0.5	-0.8	0.7
Latency to leave start box in cocaine runway, F	0.9	1.0	2.4	-0.4	-0.4	1.1	-0.9	-1.6	1.0
Latency to leave start box in cocaine runway, M	0.4	0.4	0.6	0.7	0.7	-0.8	0.6	0.5	-0.0
Std. dev. time between licks in bursts	0.7	0.8	1.8	-0.9	-0.9	-0.1	-0.0	1.2	-1.3
Total sessions with >9 infusions	1.1	1.3	1.9	-0.9	-0.8	1.4	-1.4	-1.3	0.8
Short access day 1 total inactive lever presses	1.2	1.4	2.9	-1.7	-1.6	0.7	-0.5	0.6	-1.3
Short access day 10 total inactive lever presses	0.7	0.8	1.8	0.3	0.4	-0.9	1.3	0.7	-1.1
Short access day 1 total infusions	0.2	0.2	0.6	-0.1	-0.3	0.6	-0.6	-0.7	0.2
Short access day 10 total infusions	0.4	0.4	1.0	0.1	0.1	0.7	-0.7	-1.0	0.7
Short access total infusions	0.6	0.7	1.2	-0.1	-0.1	0.9	-1.0	-1.1	1.0
Short access day 1 locomotion	1.1	1.2	2.0	-1.0	-1.0	1.4	-1.3	-1.2	0.4
Short access day 10 total locomotion	0.2	0.2	0.4	-0.3	-0.2	0.5	-0.6	-0.4	0.6
Short access total locomotion	0.7	0.7	1.1	-0.3	-0.2	0.9	-1.0	-1.1	1.0
One hour access (0.3 mA shock)	0.6	0.7	1.4	-1.2	-1.1	0.0	-0.0	1.1	-0.7
Compulsive drug intake	0.6	0.6	1.1	1.0	0.9	-0.7	0.4	0.1	1.1
One hour access (shock baseline)	1.5	1.7	3.6	-1.4	-1.3	-0.1	0.2	1.6	-1.9
Social response proportion	0.7	0.8	2.2	-0.8	-0.9	0.9	-1.5	-0.4	0.0
Social responses	0.9	1.1	2.5	-0.9	-1.0	1.2	-1.6	-0.7	0.6
Social time	0.0	0.0	0.1	0.3	0.2	-0.2	0.0	0.2	0.2
Soleus weight	0.5	1.5	2.6	1.6	1.6	-1.4	1.3	0.5	0.6
Bone: stiffness	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.1	0.3	-0.3
Tibialis anterior weight	5.2	18.0	33.2	5.8	5.8	-4.5	4.6	0.6	0.4
Time to tail flick, vehicle, before self-admin	2.0	2.1	3.4	-1.8	-1.8	1.6	-1.3	-0.5	-1.1
Time to tail flick, vehicle, after self-admin	1.2	1.3	2.7	1.6	1.6	-0.9	0.6	-0.3	1.0
Time to tail flick, test, before self-admin	1.6	1.6	2.3	-0.9	-0.9	1.5	-1.4	-1.5	1.2
Time to tail flick, test, after self-admin	1.9	2.0	3.3	-0.7	-0.7	1.5	-1.7	-1.6	1.8
Delta time to tail flick, vehicle, before/after SA	2.7	2.6	4.9	2.2	2.2	-1.7	1.3	0.4	1.1
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	0.2
Tibia length	0.0	0.0	0.1	0.0	-0.0	0.2	-0.3	-0.3	0.3
Ambulatory time before self-admin	0.6	0.6	1.1	0.8	0.8	-1.0	1.0	0.8	-0.2
Ambulatory time after self-admin	0.3	0.4	0.8	0.6	0.6	-0.0	0.1	-0.8	0.9
Bone: tissue strength	0.3	0.3	0.4	-0.6	-0.6	0.5	-0.6	-0.1	-0.1
Total heroin consumption	1.2	1.4	2.8	-1.7	-1.7	0.7	-1.1	1.0	-0.4
Bone: trabecular number	0.2	0.3	0.9	-0.1	-0.1	0.6	-0.4	-0.9	0.8
Bone: trabecular spacing	1.6	2.1	3.8	-1.7	-1.7	1.6	-1.9	-0.6	0.3
Bone: trabecular thickness	0.4	0.5	1.0	1.0	1.0	-0.7	0.7	0.1	-0.0
Bone: trabecular tissue density	1.3	1.8	2.6	-1.5	-1.5	1.6	-1.6	-0.9	0.8
Water consumed over 24 hours	0.3	0.4	0.9	-0.9	-0.9	0.5	-0.5	0.3	-0.2
Number of responses in last shaping day	1.6	1.7	3.1	-0.8	-0.9	1.6	-1.7	-1.5	0.9