Mcoln1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Mcoln1 0.07 0.04 3.2e-05 0.03 0.02 0.01 0.03 1.2e-04 9.8e-04 4.4e-02 5.4e-04
2 PL gene expression Mcoln1 0.04 0.03 7.8e-03 0.01 0.01 0.01 0.01 4.3e-02 1.6e-02 2.3e-02 3.0e-02
3 Liver intron excision ratio chr12_1570055_1570201 0.03 0.02 6.8e-03 0 0 -0 0 9.3e-02 1.8e-01 9.1e-01 2.2e-01
4 pVTA gene expression Mcoln1 0.13 0.07 4.8e-05 0.12 0.11 0.07 0.1 8.9e-06 1.2e-05 4.6e-04 3.5e-05
5 NAcc gene expression Mcoln1 0.07 0.04 2.5e-09 0.08 0.07 0.07 0.07 6.7e-10 1.4e-08 1.5e-08 8.1e-09
6 RMTg gene expression Mcoln1 0.36 0.14 1.1e-06 0.24 0.21 0.25 0.26 5.0e-07 2.7e-06 2.7e-07 1.4e-07
7 Brain gene expression Mcoln1 0.15 0.07 1.2e-15 0.12 0.17 0.17 0.17 1.8e-11 2.0e-15 2.4e-15 1.0e-15
8 Adipose gene expression Mcoln1 0.05 0.03 3.8e-04 0.01 0.02 0.01 0.01 4.8e-02 1.8e-03 8.0e-03 1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density2.23.79.8-3.1-1.1-2.1-2.1-2.01.11.0-1.9
Area under the delay curve3.84.05.81.1-0.92.42.42.1-2.1-2.02.3
BMI with tail1.23.89.2-3.0-2.60.80.80.9-2.5-2.01.5
BMI without tail1.73.68.9-2.8-3.01.01.00.9-1.6-2.01.6
Body weight4.518.985.7-9.3-6.7-0.1-0.1-0.0-3.0-3.01.5
Weight adjusted by age1.21.42.7-1.6-0.0-1.3-1.3-1.50.80.9-1.1
Bone surface1.62.813.5-3.7-1.9-1.3-1.3-1.2-0.10.0-0.9
Bone volume1.52.58.0-2.8-1.0-1.7-1.7-1.60.30.8-1.5
Breakpoint value in progressive ratio session2.12.33.1-0.2-1.51.71.71.7-1.5-1.81.4
Number of licking bursts0.91.01.7-0.70.3-1.2-1.2-1.31.21.0-0.6
Context. condit. distance diff. score2.02.47.0-2.0-2.61.01.01.1-1.0-1.70.9
Locomotion velocity, session 10.60.71.01.0-0.11.01.00.9-0.6-0.80.8
Locomotion distance, session 10.40.62.91.70.70.50.50.50.1-0.10.2
Locomotion velocity, session 20.40.40.70.6-0.10.80.80.9-0.3-0.70.8
Locomotion distance, session 20.50.84.02.00.80.40.40.60.90.2-0.1
Locomotion velocity, session 30.20.30.6-0.3-0.80.50.50.4-0.5-0.60.4
Locomotion distance, session 30.50.61.00.30.5-0.7-0.7-0.81.00.9-0.9
Stereotopy head waving bouts, day 30.91.14.3-2.1-0.9-0.9-0.9-1.00.50.2-0.7
Stereotopy head waving duration, day 30.10.10.2-0.40.2-0.4-0.4-0.40.00.2-0.3
Locomotion velocity, session 72.52.74.10.6-0.81.91.91.8-1.8-1.72.0
Locomotion distance, session 71.11.42.30.7-0.81.51.51.4-0.8-1.21.3
Stereotopy head waving bouts, day 70.20.21.21.10.50.30.30.30.2-0.10.0
Stereotopy head waving duration, day 70.20.21.11.00.60.30.30.20.0-0.00.1
Locomotion velocity, session 80.80.91.3-0.3-0.90.90.91.0-1.0-1.11.1
Locomotion distance, session 80.81.22.8-1.1-1.70.90.91.0-0.8-1.20.9
Degree of sensitization distance1.41.42.11.1-0.21.41.41.4-0.9-1.11.4
Degree of sensitization stereotypy0.20.20.60.80.20.60.60.6-0.3-0.30.4
Conditioned locomotion0.60.71.3-0.10.5-0.8-0.8-1.00.70.9-1.2
Cocaine response after cond. corrected0.30.30.8-0.70.4-0.7-0.7-0.5-0.90.20.0
Cocaine response after cond. not corrected0.30.31.7-0.5-0.10.10.10.1-1.3-0.40.4
Cocaine response before conditioning1.01.21.90.3-1.31.41.41.2-0.6-1.30.7
Saline control response0.70.92.5-1.6-1.1-0.5-0.5-0.81.30.2-0.6
Bone: connectivity density2.03.213.5-3.7-2.0-1.5-1.5-1.30.60.1-1.1
Bone: cortical apparent density0.71.01.40.7-0.11.21.21.1-1.1-0.81.2
Bone: cortical area1.62.45.2-2.0-2.31.01.01.0-1.6-1.51.3
Bone: cortical porosity0.10.10.2-0.30.1-0.3-0.3-0.40.30.3-0.3
Bone: cortical porosity0.00.10.20.50.10.20.20.10.20.0-0.1
Bone: cortical thickness1.22.04.4-2.0-2.10.90.90.8-1.5-1.31.1
Bone: cortical thickness0.50.62.0-1.1-1.40.50.50.4-0.2-0.60.5
Bone: cortical tissue density0.60.71.00.80.01.01.00.9-1.0-0.61.0
Condit. Reinf. active minus inactive responses0.40.50.80.90.20.80.80.6-0.8-0.50.6
Condit. Reinf. active-inactive response ratio0.70.71.40.4-0.31.01.00.9-1.2-0.90.9
Condit. Reinf. active responses0.40.41.21.10.00.80.80.7-0.3-0.50.4
Condit. Reinf. inactive responses0.40.52.21.50.30.60.60.60.5-0.20.0
Incentive salience index mean0.30.31.21.10.20.70.70.5-0.3-0.30.3
Condit. Reinf. lever presses0.20.21.01.00.00.50.50.50.2-0.2-0.1
Condit. Reinf. active minus inactive responses2.53.14.8-1.0-2.21.71.71.8-1.4-2.21.9
Condit. Reinf. active-inactive response ratio2.72.84.1-0.3-1.61.71.71.9-1.4-2.02.0
Condit. Reinf. active responses2.53.56.1-1.0-2.51.81.81.8-1.4-2.31.8
Condit. Reinf. inactive responses0.20.20.8-0.6-0.90.30.30.2-0.0-0.4-0.0
Condit. Reinf. lever presses0.40.51.1-0.1-1.00.70.70.8-0.5-1.00.5
Condit. Reinf. lever reinforcers received2.43.45.2-0.6-2.31.91.91.9-1.4-2.31.9
Conditioned reinforcement - actives1.11.14.0-2.0-2.00.10.10.20.1-0.80.5
Conditioned reinforcement - inactives0.70.81.5-0.40.2-1.0-1.0-1.01.20.9-0.9
Conditioned locomotion0.60.73.1-1.4-1.80.20.20.20.4-0.60.1
Patch foraging indifference point 0 sec2.43.85.7-0.21.3-2.1-2.1-2.22.12.3-2.4
Patch foraging indifference point AUC0.30.31.2-1.1-0.7-0.4-0.4-0.60.6-0.0-0.3
Delay disc. indifference point, 0s delay3.94.38.4-0.4-1.42.02.01.9-2.9-2.22.7
Delay disc. indifference point, 16s delay1.21.21.90.8-0.41.41.41.1-1.0-1.01.3
Delay disc. indifference point, 2s delay4.65.17.21.7-0.62.72.72.3-2.6-2.22.4
Delay disc. indifference point, 24s delay0.80.81.21.00.01.11.10.8-0.6-0.71.0
Delay disc. indifference point, 4s delay2.22.33.40.9-0.51.81.81.6-1.8-1.51.6
Delay disc. indifference point, 8s delay1.31.42.21.1-0.51.51.51.3-0.8-1.11.2
Indifference point function ln k0.20.31.00.40.3-0.4-0.4-0.21.00.6-0.6
Indifference point function log k0.20.31.00.40.3-0.4-0.4-0.21.00.6-0.6
Patch foraging total patch changes 0 sec3.15.07.5-0.01.5-2.3-2.3-2.52.62.5-2.7
Patch foraging total patch changes 12 sec1.21.52.6-0.80.5-1.4-1.4-1.61.01.3-1.5
Patch foraging total patch changes 18 sec3.14.05.7-0.41.2-2.2-2.2-2.42.22.1-2.3
Patch foraging total patch changes 24 sec2.12.56.00.50.8-1.4-1.4-1.62.41.6-2.1
Patch foraging total patch changes 6 sec2.13.14.7-0.60.8-2.0-2.0-2.12.01.7-2.2
Patch foraging time to switch 0 sec1.11.77.20.70.70.90.91.0-2.7-0.71.5
Patch foraging water rate 0 sec2.54.110.0-1.4-0.5-2.0-2.0-2.13.21.5-2.4
Patch foraging water rate 12 sec0.40.62.90.3-0.3-0.4-0.4-0.61.70.5-0.9
Patch foraging water rate 18 sec0.40.51.11.0-0.60.90.90.80.6-0.50.3
Patch foraging water rate 24 sec0.50.72.0-1.0-1.1-0.4-0.4-0.31.40.2-0.8
Patch foraging water rate 6 sec0.40.62.5-0.0-0.4-0.6-0.6-0.41.60.5-1.2
Seeking ratio, delayed vs. immediate footshock2.02.35.11.52.3-1.2-1.2-1.21.31.8-1.2
Distance traveled before self-admin1.21.32.41.2-0.21.31.31.6-0.7-1.01.1
Distance traveled after self-admin0.20.30.50.2-0.40.70.70.6-0.1-0.60.5
Extensor digitorum longus weight1.66.224.8-5.0-4.40.30.30.3-1.0-1.80.6
Bone: elastic displacement0.20.20.7-0.8-0.4-0.5-0.5-0.40.30.2-0.4
Bone: elastic work1.11.46.3-2.5-1.6-0.8-0.8-0.80.30.0-0.5
Bone: endosteal estimation0.71.52.1-1.3-0.3-1.5-1.5-1.31.31.0-1.3
Bone: endosteal perimeter0.20.41.2-1.0-1.1-0.2-0.2-0.20.5-0.1-0.4
Epididymis fat weight0.20.40.7-0.2-0.70.70.70.6-0.7-0.90.3
Delta time in closed arm before/after self-admin0.60.61.30.3-0.61.21.20.8-0.1-0.70.7
Delta time in open arm before/after self-admin0.50.52.01.41.4-0.1-0.1-0.1-0.20.4-0.3
Diff in mean of infusions in LGA sessions0.10.10.20.0-0.40.30.30.30.0-0.3-0.0
Delay discount exponential model param3.84.06.1-1.30.8-2.5-2.5-2.22.02.0-2.2
Extinction: sum of active levers before priming0.60.61.11.10.21.01.00.8-0.7-0.60.6
Active lever presses in extinction session 60.00.00.1-0.4-0.3-0.1-0.10.1-0.1-0.1-0.0
Bone: final force1.01.65.6-2.4-2.10.40.40.3-0.9-1.00.9
Bone: final moment0.81.24.9-2.2-1.80.20.20.1-0.7-0.80.7
Food consumed during 24 hour testing period0.80.91.7-0.40.4-1.3-1.3-1.01.01.0-0.9
Glucose0.50.81.40.60.10.90.90.9-1.2-0.81.1
Heart weight0.50.71.71.0-0.60.70.71.21.3-0.60.3
Delay discount hyperbolic model param3.63.85.8-1.40.7-2.4-2.4-2.12.01.9-2.2
Intermittent access intake day 1-15 change1.41.42.0-1.2-0.1-1.4-1.4-1.41.21.0-1.1
Intermittent access intake escalation0.80.81.2-1.1-0.4-1.0-1.0-1.01.00.6-0.8
Intermittent access intake escalation 20.50.51.1-0.10.3-0.8-0.8-0.81.00.7-0.8
Intermitt. access day 1 inactive lever presses1.51.63.3-0.20.6-1.3-1.3-1.41.81.3-1.4
Intermitt. access day 15 inactive lever presses1.01.11.8-0.41.1-1.4-1.4-1.30.21.2-0.9
Intermitt. access escalation Index0.20.20.91.00.00.40.40.50.5-0.1-0.1
Intermittent access day 1 total infusions0.91.02.11.40.01.21.21.3-0.2-0.70.8
Intermittent access day 15 total infusions0.10.10.60.3-0.0-0.1-0.1-0.00.80.2-0.3
Intermittent access terminal intake (last 3 days)0.10.10.30.60.4-0.0-0.00.00.30.2-0.2
Intermittent access total infusions0.40.50.90.90.00.90.90.9-0.4-0.60.6
Intermittent access day 1 locomotion1.41.54.22.00.31.51.51.5-0.4-0.80.7
Intermittent access day 15 total locomotion0.60.71.21.1-0.61.01.01.00.7-0.60.2
Intermittent access total locomotion1.41.63.61.9-0.21.61.61.6-0.0-0.90.7
Intermittent access standard deviation1.92.03.4-1.00.8-1.8-1.8-1.80.91.5-1.4
Left kidney weight2.46.832.1-5.7-4.4-0.6-0.6-0.6-0.1-1.40.2
Right kidney weight2.26.030.5-5.5-3.8-0.7-0.7-0.7-0.4-1.20.2
Cocaine induced anxiety0.40.50.90.9-0.10.80.80.9-0.4-0.60.3
Post-drug Anxiety2.52.74.62.10.41.91.92.0-1.5-1.21.5
Baseline Anxiety1.31.42.51.40.91.11.11.2-1.6-0.61.3
Tail length2.57.727.2-5.2-4.80.80.80.6-1.3-2.41.5
Length with tail4.616.977.3-8.8-6.8-0.0-0.0-0.1-1.8-2.71.3
Length without tail3.16.832.5-5.7-3.9-0.3-0.3-0.2-1.9-1.50.6
Times rat made contact with spout0.40.51.4-0.8-1.20.40.40.5-0.5-0.70.7
Lifetime Intake0.30.30.50.70.20.60.60.7-0.7-0.40.6
Liver weight, left2.23.55.2-1.60.5-2.3-2.3-2.21.71.7-2.0
Liver weight, right1.01.77.6-2.8-1.7-0.9-0.9-0.90.5-0.1-0.7
Locomotor activity1.11.75.6-1.3-2.41.21.20.90.1-1.40.9
Locomotor testing distance0.40.61.5-1.0-0.6-0.5-0.5-0.71.20.4-0.8
Locomotor testing rearing0.81.22.20.10.8-1.1-1.1-1.11.41.2-1.5
Locomotion in novel chamber0.20.21.3-0.0-0.3-0.1-0.1-0.11.10.2-0.4
Locomotion in novel chamber post-restriction0.60.83.3-1.2-1.80.40.40.40.4-0.80.2
Fecal boli incidents, locomotor time 10.40.41.7-0.7-1.30.30.30.40.1-0.60.2
Change in fecal boli incidents, locomotor task0.30.31.0-0.01.0-0.5-0.5-0.6-0.20.6-0.2
Time >=10cm from walls, locomotor time 11.31.32.61.20.21.31.31.1-1.6-1.01.1
Bouts of movement, locomotor time 10.30.31.4-1.2-1.1-0.0-0.0-0.20.2-0.30.0
Total resting periods, locomotor time 10.30.31.2-1.0-1.10.20.2-0.00.0-0.50.2
Rest time, locomotor task time 10.20.20.7-0.8-0.80.10.1-0.1-0.3-0.40.2
Distance moved, locomotor task time 10.20.20.60.80.10.50.50.6-0.1-0.30.4
Vertical activity count, locomotor time 10.10.10.3-0.1-0.50.40.40.30.1-0.30.3
Time >=10cm from walls, locomotor time 21.41.53.2-0.8-1.21.11.11.0-1.8-1.41.2
Bouts of movement, locomotor time 20.40.41.8-1.3-1.1-0.1-0.1-0.20.2-0.3-0.2
Total resting periods, locomotor time 20.40.41.9-1.4-0.9-0.3-0.3-0.40.3-0.1-0.4
Rest time, locomotor task time 20.00.00.10.30.20.10.10.1-0.20.0-0.1
Distance moved, locomotor task time 20.10.10.3-0.10.1-0.4-0.4-0.60.60.3-0.1
Vertical activity count, locomotor time 20.70.72.0-1.4-0.8-0.7-0.7-0.91.10.3-0.4
Light reinforcement 11.42.63.91.1-0.51.91.92.0-1.5-1.61.8
Light reinforcement 20.20.20.60.60.8-0.3-0.3-0.30.60.6-0.3
Bone: marrow area0.81.72.3-1.3-0.2-1.5-1.5-1.41.51.0-1.4
Bone: maximum diameter0.40.84.0-2.0-1.4-0.4-0.4-0.4-0.3-0.2-0.1
Bone: maximum force0.61.04.8-2.2-1.8-0.1-0.1-0.3-0.2-0.50.1
Bone: maximum moment0.50.84.1-2.0-1.5-0.3-0.3-0.5-0.0-0.2-0.1
Mean time between licks in bursts0.60.93.11.81.5-0.3-0.3-0.30.80.8-0.7
Mean num. licks in bursts0.40.50.80.1-0.60.80.80.9-0.8-0.80.5
Cd content in liver1.71.84.61.91.6-0.7-0.7-0.42.11.3-1.2
Co content in liver2.02.43.7-0.20.8-1.8-1.8-1.61.91.6-1.7
Cu content in liver0.60.81.40.50.7-0.8-0.8-0.71.20.9-1.2
Fe content in liver0.70.93.4-1.2-1.90.50.50.7-0.1-0.90.1
K content in liver0.10.10.1-0.2-0.30.10.10.3-0.3-0.30.1
Mg content in liver0.10.10.6-0.8-0.6-0.0-0.0-0.0-0.2-0.30.1
Mn content in liver0.50.51.30.71.2-0.7-0.7-0.30.40.8-0.5
Na content in liver0.60.60.8-0.5-0.80.70.70.8-0.9-0.90.8
Rb content in liver0.50.62.91.71.20.10.10.30.10.3-0.4
Se content in liver2.32.84.1-1.0-1.91.61.61.8-2.0-1.91.4
Sr content in liver2.52.33.5-0.61.0-1.8-1.8-1.91.41.6-1.5
Zn content in liver2.12.35.0-2.2-0.5-1.7-1.7-1.71.11.0-1.4
Bone: minimum diameter0.00.00.1-0.00.1-0.2-0.2-0.20.20.3-0.2
Time in familiar zone, hab. session 11.61.52.20.21.4-1.4-1.4-1.50.81.5-1.2
Time in novel zone, hab. session 10.90.91.4-0.6-1.20.90.91.0-0.8-1.10.9
Total zone transitions, hab. session 10.91.34.12.00.31.31.31.3-0.3-0.70.8
Total locomotion distance, hab. session 10.60.91.41.2-0.11.11.11.2-0.8-0.80.7
Locomotion velocity, hab. session 11.01.43.31.80.21.41.41.4-0.8-0.90.9
Time in familiar zone, hab. session 20.10.10.3-0.20.2-0.2-0.2-0.3-0.50.1-0.0
Time in novel zone, hab. session 20.20.20.70.8-0.00.60.60.60.2-0.20.3
Total zone transitions, hab. session 20.10.10.3-0.0-0.40.40.40.40.0-0.40.5
Total locomotion distance, hab. session 20.10.20.40.70.00.50.50.5-0.0-0.30.4
Locomotion velocity, hab. session 20.10.20.40.70.10.50.50.40.0-0.30.4
Novel to familiar place preference ratio0.10.10.30.2-0.10.40.40.4-0.1-0.40.6
Novelty place preference0.20.20.30.50.20.40.40.5-0.1-0.30.5
Time in novel zone, NPP test0.10.10.30.30.00.40.40.4-0.1-0.40.5
Total zone transitions, NPP test0.20.30.50.2-0.60.70.70.7-0.3-0.70.6
Total locomotion distance, NPP test1.21.62.40.5-0.91.51.51.5-1.1-1.41.1
Locomotion velocity, NPP test1.01.52.30.6-1.01.51.51.5-0.7-1.41.1
Intraocular pressure0.40.61.7-1.3-1.1-0.4-0.4-0.60.60.1-0.6
Delta distance traveled before/after self-admin0.40.40.9-0.60.1-0.6-0.6-0.90.80.6-0.6
Delta ambulatory time before/after self-admin0.30.30.8-0.00.5-0.4-0.4-0.90.60.6-0.6
Parametrial fat weight0.20.40.8-0.90.3-0.8-0.8-0.8-0.10.5-0.3
Pavlov. Cond. lever latency0.81.14.5-2.1-0.9-1.0-1.0-0.90.40.2-0.5
Pavlov. Cond. magazine entry latency0.30.40.7-0.3-0.80.70.70.6-0.5-0.70.6
Pavlov. Cond. change in total contacts1.61.82.70.5-0.51.51.51.5-1.6-1.41.5
Pavlov. Cond. index score0.40.60.90.4-0.40.90.90.9-0.8-0.70.7
Pavlov. Cond. latency score0.70.81.30.7-0.31.21.21.1-0.9-0.90.9
Pavlov. Cond. lever contacts0.60.82.61.60.60.90.90.8-0.6-0.40.5
Pavlov. Cond. magazine entry number0.50.71.50.41.2-0.9-0.9-0.80.40.9-0.6
Pavlov. Cond. intertrial magazine entries0.60.72.01.41.2-0.4-0.4-0.50.90.9-0.6
Pavlov. Cond. lever-magazine prob. diff.0.30.40.50.3-0.30.70.70.7-0.7-0.60.6
Pavlov. Cond. response bias0.40.50.6-0.0-0.70.80.80.8-0.6-0.80.6
Pavlov. Cond. lever latency2.02.74.6-0.61.3-1.9-1.9-2.11.31.9-1.6
Pavlov. Cond. magazine entry latency2.83.24.61.4-0.52.12.12.1-1.8-1.71.9
Pavlov. Cond. change in total contacts1.01.32.30.8-0.81.41.41.5-0.6-1.31.1
Pavlov. Cond. index score2.22.84.61.3-0.82.02.02.1-1.3-1.71.6
Pavlov. Cond. latency score2.12.64.21.3-0.71.91.92.0-1.3-1.71.6
Pavlov. Cond. lever contacts1.62.23.90.7-1.01.71.72.0-1.3-1.71.4
Pavlov. Cond. magazine entry number2.02.43.8-1.80.2-1.8-1.8-1.91.21.4-1.5
Pavlov. Cond. intertrial magazine entries0.20.20.6-0.8-0.5-0.4-0.4-0.40.70.2-0.4
Pavlov. Cond. lever-magazine prob. diff.2.32.94.91.4-0.82.12.12.2-1.3-1.71.7
Pavlov. Cond. response bias2.53.45.71.3-1.02.22.22.4-1.4-2.01.7
Time in closed arm before self-admin1.01.11.9-1.3-0.4-1.4-1.4-0.91.10.6-0.8
Time in closed arm after self-admin0.30.31.6-0.2-0.80.10.10.11.30.0-0.3
Time in open arm before self-admin0.40.40.70.0-0.60.80.80.6-0.4-0.70.8
Time in open arm after self-admin0.10.10.6-0.10.30.00.0-0.2-0.8-0.10.2
Bone: periosteal estimation0.40.94.3-2.1-1.6-0.3-0.3-0.3-0.1-0.3-0.1
Bone: periosteal perimeter0.61.03.0-0.9-1.70.90.90.9-0.7-1.10.6
Bone: post-yield work0.10.20.4-0.5-0.3-0.4-0.4-0.40.30.2-0.6
Progressive ratio test 1 active lever presses0.10.10.3-0.5-0.50.10.10.20.1-0.20.2
Progressive ratio test 1 breakpoint0.10.10.4-0.6-0.60.10.10.2-0.1-0.30.4
Progressive ratio test 1 inactive lever presses0.40.41.7-0.5-0.4-0.5-0.5-0.51.30.4-0.6
Progressive ratio test 2 active lever presses0.50.51.4-0.4-1.20.60.60.80.3-0.70.5
Progressive ratio test 2 breakpoint0.60.61.10.1-1.00.90.91.10.2-0.80.8
Progressive ratio test 2 inactive lever presses1.41.64.8-0.9-0.6-1.2-1.2-1.12.20.9-1.4
Incentive Sensitization - Responses0.20.30.50.7-0.30.50.50.70.4-0.30.2
Incentive Sensitization - Breakpoint0.30.30.60.7-0.30.60.60.70.5-0.30.2
Sum of active levers in priming session hrs 5-60.40.41.90.10.10.50.50.5-1.4-0.60.6
Progressive ratio0.50.61.41.01.2-0.4-0.4-0.60.70.8-0.5
Food seeking constrained by brief footshock3.23.95.30.92.2-1.9-1.9-2.12.02.3-2.2
Seeking ratio, punishment vs. effort0.30.40.9-1.0-0.3-0.7-0.7-0.60.40.4-0.6
Retroperitoneal fat weight0.93.08.80.90.01.61.61.9-3.0-1.61.7
Reaction time number correct0.91.22.5-0.70.0-1.2-1.2-1.31.60.8-1.3
Reaction time mean minus median5.57.39.9-0.0-2.53.23.22.9-2.5-3.22.7
Reaction time mean minus median AUC1.92.44.21.0-1.02.02.01.8-1.0-1.71.4
Reaction time num false alarms1.62.13.50.9-1.01.91.91.9-0.8-1.41.4
Reaction time num false alarms AUC1.01.32.30.7-0.91.51.51.4-0.5-1.20.9
Reaction time trials correct on left0.91.22.5-0.70.0-1.2-1.2-1.31.60.8-1.3
Reaction time trials on left0.81.12.3-0.6-0.0-1.1-1.1-1.21.50.8-1.2
Reaction time mean2.94.15.61.90.02.42.42.3-2.2-1.72.2
Reaction time mean AUC2.83.75.32.00.12.32.32.1-2.0-1.52.1
Median of all reaction times2.12.95.52.30.91.81.81.8-1.8-0.91.8
Reaction time omissions1.31.82.71.3-0.31.71.71.2-1.2-1.41.4
Reaction time false alarm rate1.82.54.20.9-1.02.02.01.9-1.2-1.61.5
Reaction time premature initiation rate0.81.01.50.2-0.81.21.21.1-0.9-1.11.1
Reaction time premature initiations0.20.30.5-0.1-0.70.60.60.4-0.2-0.70.4
Std. dev. reaction times3.44.76.90.8-1.32.62.62.4-2.3-2.32.3
Reaction time trials completed0.81.12.3-0.6-0.0-1.1-1.1-1.21.50.8-1.2
Reaction time trials AUC0.81.12.5-0.40.1-1.1-1.1-1.21.60.8-1.3
Run reversals in cocaine runway, females0.20.20.60.70.7-0.4-0.4-0.20.20.4-0.4
Run reversals in cocaine runway, males0.80.82.60.50.5-0.7-0.7-0.61.60.9-0.9
Latency to leave start box in cocaine runway0.50.51.0-0.0-0.20.80.80.8-0.9-0.71.0
Latency to leave start box in cocaine runway, F0.20.20.8-0.9-0.1-0.1-0.1-0.0-0.7-0.10.4
Latency to leave start box in cocaine runway, M0.80.71.81.3-0.11.01.01.20.2-0.60.4
Std. dev. time between licks in bursts0.10.10.40.0-0.60.40.40.20.3-0.2-0.0
Total sessions with >9 infusions0.20.20.3-0.0-0.40.50.50.5-0.6-0.50.5
Short access day 1 total inactive lever presses0.30.40.50.00.5-0.7-0.7-0.70.70.7-0.6
Short access day 10 total inactive lever presses2.22.43.6-1.7-0.0-1.9-1.9-1.91.31.3-1.6
Short access day 1 total infusions0.70.82.40.71.6-0.8-0.8-0.8-0.21.0-0.6
Short access day 10 total infusions0.20.20.91.00.70.20.20.2-0.20.1-0.0
Short access total infusions0.20.31.30.20.60.20.20.2-1.2-0.10.5
Short access day 1 locomotion1.71.82.71.5-0.01.71.71.6-1.0-1.11.4
Short access day 10 total locomotion0.40.40.90.90.9-0.4-0.4-0.40.60.7-0.8
Short access total locomotion0.60.61.21.10.40.90.90.9-0.9-0.50.7
One hour access (0.3 mA shock)0.60.73.50.70.3-0.4-0.4-0.31.90.7-0.8
Compulsive drug intake1.11.24.32.11.8-0.2-0.2-0.10.80.9-0.5
One hour access (shock baseline)0.40.41.9-0.7-1.40.40.40.50.5-0.60.2
Social response proportion4.44.89.6-2.3-3.11.81.81.7-1.7-2.42.3
Social responses0.81.03.9-1.3-2.00.70.70.50.2-1.00.5
Social time1.21.65.32.30.71.41.40.9-0.5-0.61.1
Soleus weight0.41.14.6-2.2-1.6-0.6-0.6-0.50.40.1-0.8
Bone: stiffness0.60.92.3-0.7-1.51.01.00.7-0.5-1.10.9
Tibialis anterior weight2.58.530.0-5.5-5.00.80.80.6-1.8-2.51.3
Time to tail flick, vehicle, before self-admin2.32.43.70.8-0.41.71.71.8-1.8-1.51.9
Time to tail flick, vehicle, after self-admin0.70.71.40.7-0.31.01.01.2-0.6-0.80.9
Time to tail flick, test, before self-admin0.30.31.6-1.3-0.6-0.3-0.3-0.40.0-0.0-0.0
Time to tail flick, test, after self-admin0.40.41.3-0.5-0.40.50.50.4-1.1-0.50.7
Delta time to tail flick, vehicle, before/after SA0.40.40.80.50.6-0.5-0.5-0.40.90.7-0.8
Delta time to tail flick, test, before/after SA0.10.10.20.50.5-0.0-0.0-0.1-0.30.2-0.2
Tibia length1.33.720.3-4.5-2.4-0.6-0.6-0.9-1.1-0.60.6
Ambulatory time before self-admin1.92.03.71.0-0.81.71.71.9-1.0-1.51.3
Ambulatory time after self-admin0.40.50.90.3-0.50.90.90.8-0.5-0.70.6
Bone: tissue strength2.32.23.2-0.11.3-1.7-1.7-1.81.31.6-1.6
Total heroin consumption1.92.25.02.20.31.81.81.8-0.8-1.11.0
Bone: trabecular number1.42.19.2-3.0-1.5-1.2-1.2-1.20.30.2-0.9
Bone: trabecular spacing0.91.15.62.41.70.20.20.10.20.5-0.1
Bone: trabecular thickness1.41.78.1-2.8-1.8-0.7-0.7-0.6-0.1-0.2-0.6
Bone: trabecular tissue density6.08.511.30.2-2.33.33.33.4-2.9-3.13.3
Water consumed over 24 hours0.80.92.9-1.7-0.9-1.0-1.0-0.80.80.3-0.5
Number of responses in last shaping day0.10.10.20.10.2-0.4-0.4-0.30.50.3-0.4