Hub : Genes

Mcoln1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Mcoln1 0.07 0.04 3.4e-05 0.03 0.03 0.02 0.03 1.1e-04 4.1e-04 2.9e-03 6.8e-04
2 PL gene expression Mcoln1 0.04 0.03 6.8e-03 0.01 0.01 0.01 0.01 1.0e-02 5.3e-02 5.6e-02 3.3e-02
3 RMTg gene expression Mcoln1 0.3 0.13 9.4e-06 0.24 0.21 0.22 0.23 5.9e-07 2.5e-06 1.9e-06 7.0e-07
4 Liver intron excision ratio chr12_6367954_6368100 0.03 0.02 6.1e-03 0 0 0 0 9.6e-02 1.7e-01 1.9e-01 2.0e-01
5 BLA gene expression Mcoln1 0.06 0.04 5.2e-03 0 0.02 -0 0 2.7e-01 2.4e-02 7.4e-01 1.6e-01
6 pVTA gene expression Mcoln1 0.14 0.06 5.3e-11 0.12 0.15 0.15 0.16 3.5e-10 4.3e-12 4.8e-12 1.2e-12
7 Brain gene expression Mcoln1 0.15 0.07 1.7e-16 0.17 0.19 0.19 0.19 5.8e-16 1.2e-17 2.9e-17 3.1e-17
8 Adipose gene expression Mcoln1 0.04 0.03 7.1e-04 0 0.01 0 0 1.9e-01 7.6e-03 1.1e-01 8.2e-02
9 NAcc gene expression Mcoln1 0.06 0.03 1.6e-10 0.08 0.07 0.08 0.07 8.7e-12 1.6e-11 7.7e-12 1.6e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density1.52.67.82.8-0.72.02.00.60.41.1-1.91.2
Area under the delay curve2.83.25.2-1.0-0.9-2.3-2.3-1.7-1.5-1.92.1-1.8
BMI with tail0.41.59.53.1-1.21.00.7-0.6-0.7-0.4-0.1-0.1
BMI without tail1.44.415.63.9-3.0-0.2-0.4-2.0-2.1-1.71.2-1.5
Body weight4.017.481.79.0-5.80.60.4-3.4-3.7-2.71.5-2.4
Weight adjusted by age0.50.82.41.50.11.01.00.50.50.7-0.81.0
Bone surface1.01.911.63.4-1.51.11.0-0.4-0.7-0.0-0.7-0.0
Bone volume0.91.56.32.5-0.51.51.40.30.10.7-1.40.8
Breakpoint value in progressive ratio session1.31.52.00.1-1.2-1.3-1.3-1.4-1.4-1.31.1-1.4
Number of licking bursts0.40.61.41.00.01.21.20.80.50.7-0.30.3
Context. condit. distance diff. score2.32.85.92.0-2.4-1.1-1.0-1.9-1.9-1.60.9-1.4
Locomotion velocity, session 10.50.50.8-0.80.0-0.9-0.9-0.5-0.8-0.60.8-0.7
Locomotion distance, session 10.30.42.6-1.60.6-0.6-0.60.1-0.0-0.10.2-0.1
Locomotion velocity, session 20.40.50.8-0.6-0.3-0.8-0.8-0.5-0.6-0.60.9-0.7
Locomotion distance, session 20.30.53.4-1.80.4-0.4-0.40.20.20.10.10.0
Locomotion velocity, session 30.20.30.40.4-0.7-0.5-0.5-0.7-0.5-0.60.3-0.4
Locomotion distance, session 30.50.50.9-0.30.40.70.70.70.90.8-0.90.9
Stereotopy head waving bouts, day 30.70.83.61.9-0.81.01.00.10.40.4-0.70.5
Stereotopy head waving duration, day 30.20.20.30.10.40.50.50.50.50.5-0.40.5
Locomotion velocity, session 72.52.74.0-0.8-0.6-2.0-2.0-1.5-1.7-1.72.0-1.9
Locomotion distance, session 71.21.52.3-0.8-0.9-1.5-1.5-1.2-1.1-1.31.3-1.3
Stereotopy head waving bouts, day 70.10.10.4-0.60.0-0.4-0.4-0.1-0.1-0.20.2-0.1
Stereotopy head waving duration, day 70.10.20.9-0.90.5-0.4-0.40.1-0.1-0.10.3-0.1
Locomotion velocity, session 80.81.01.40.3-0.8-1.0-1.0-1.0-1.1-1.11.2-1.1
Locomotion distance, session 81.11.52.61.2-1.6-0.9-0.9-1.4-1.6-1.21.0-1.2
Degree of sensitization distance1.31.32.0-1.2-0.3-1.4-1.4-0.9-1.0-1.11.4-1.3
Degree of sensitization stereotypy0.20.20.4-0.70.2-0.6-0.6-0.3-0.4-0.30.4-0.3
Conditioned locomotion0.80.91.60.10.60.90.90.91.21.0-1.31.2
Cocaine response after cond. corrected0.40.41.20.71.10.90.80.60.30.4-0.20.5
Cocaine response after cond. not corrected0.10.10.40.70.60.10.1-0.1-0.3-0.20.2-0.1
Cocaine response before conditioning1.21.52.3-0.2-1.4-1.5-1.4-1.5-1.3-1.30.7-1.1
Saline control response0.60.84.01.7-2.00.40.4-0.4-0.2-0.0-0.4-0.0
Bone: connectivity density1.42.211.83.4-1.81.31.3-0.3-0.60.2-1.00.3
Bone: cortical apparent density0.40.61.1-0.50.1-1.0-0.9-0.6-0.6-0.81.0-0.8
Bone: cortical area2.23.44.92.0-2.2-1.3-1.3-2.1-2.1-2.01.6-1.8
Bone: cortical porosity0.20.20.30.10.10.50.50.40.50.5-0.50.5
Bone: cortical porosity0.00.00.3-0.50.10.0-0.00.10.20.2-0.20.2
Bone: cortical thickness1.42.33.71.9-1.9-0.9-1.0-1.7-1.6-1.51.3-1.4
Bone: cortical thickness0.91.12.71.2-1.7-0.6-0.7-1.2-1.0-1.00.8-0.9
Bone: cortical tissue density0.30.40.8-0.60.2-0.9-0.8-0.4-0.4-0.60.9-0.6
Condit. Reinf. active minus inactive responses0.30.40.7-0.80.4-0.8-0.8-0.4-0.4-0.50.6-0.5
Condit. Reinf. active-inactive response ratio0.50.51.0-0.30.0-1.0-1.0-0.7-0.8-0.80.8-0.7
Condit. Reinf. active responses0.30.41.0-1.00.0-0.8-0.8-0.5-0.5-0.50.4-0.4
Condit. Reinf. inactive responses0.30.32.0-1.4-0.1-0.6-0.6-0.2-0.0-0.20.0-0.2
Incentive salience index mean0.20.31.1-1.10.3-0.7-0.7-0.3-0.3-0.30.2-0.3
Condit. Reinf. lever presses0.10.21.2-1.10.1-0.5-0.5-0.2-0.1-0.1-0.2-0.1
Condit. Reinf. active minus inactive responses2.93.85.20.9-2.2-1.7-1.6-2.1-2.3-2.12.0-2.2
Condit. Reinf. active-inactive response ratio2.63.04.50.2-1.6-1.6-1.6-1.8-2.1-1.82.0-2.1
Condit. Reinf. active responses3.04.16.21.0-2.5-1.8-1.8-2.3-2.3-2.21.9-2.1
Condit. Reinf. inactive responses0.20.31.10.6-1.0-0.4-0.4-0.7-0.4-0.50.0-0.3
Condit. Reinf. lever presses0.50.71.20.1-0.9-0.8-0.8-1.1-1.1-1.00.6-0.9
Condit. Reinf. lever reinforcers received2.83.95.30.5-2.3-1.9-1.9-2.2-2.2-2.11.9-2.1
Conditioned reinforcement - actives0.81.34.72.2-1.80.30.0-1.0-1.0-0.80.5-0.6
Conditioned reinforcement - inactives0.50.71.70.5-0.01.30.90.70.80.8-0.80.9
Conditioned locomotion0.91.14.11.4-2.0-0.1-0.4-1.2-1.1-0.90.3-0.5
Patch foraging indifference point 0 sec2.14.06.20.11.32.22.22.12.02.2-2.52.2
Patch foraging indifference point AUC0.30.52.71.7-0.70.50.60.00.20.2-0.30.3
Delay disc. indifference point, 0s delay3.94.37.30.8-1.3-2.2-2.0-2.2-2.2-2.42.7-2.3
Delay disc. indifference point, 16s delay0.80.91.6-0.6-0.3-1.2-1.3-0.9-0.7-1.01.1-1.1
Delay disc. indifference point, 2s delay3.74.17.9-1.6-0.5-2.8-2.7-1.9-1.7-2.12.2-1.8
Delay disc. indifference point, 24s delay0.50.51.1-1.10.0-0.8-1.0-0.5-0.3-0.70.9-0.7
Delay disc. indifference point, 4s delay1.92.04.0-0.9-0.6-2.0-1.9-1.4-1.2-1.61.5-1.2
Delay disc. indifference point, 8s delay0.91.11.8-0.9-0.9-1.3-1.4-1.0-0.8-1.11.1-0.9
Indifference point function ln k0.10.10.4-0.6-0.10.40.20.20.10.3-0.40.1
Indifference point function log k0.10.10.4-0.6-0.10.40.20.20.10.3-0.40.1
Patch foraging total patch changes 0 sec2.85.38.30.01.52.52.52.42.32.6-2.92.6
Patch foraging total patch changes 12 sec1.62.02.81.20.81.61.61.31.31.4-1.71.6
Patch foraging total patch changes 18 sec2.64.05.60.71.32.32.32.11.92.2-2.42.1
Patch foraging total patch changes 24 sec1.52.65.3-0.20.61.71.71.51.71.8-2.31.9
Patch foraging total patch changes 6 sec2.23.35.40.61.02.22.21.81.62.0-2.32.0
Patch foraging time to switch 0 sec0.40.92.1-0.71.4-1.1-1.0-0.4-0.5-0.81.5-0.8
Patch foraging water rate 0 sec1.12.44.81.2-1.02.12.01.01.01.5-2.21.2
Patch foraging water rate 12 sec0.10.20.6-0.4-0.80.40.30.10.10.3-0.80.2
Patch foraging water rate 18 sec0.40.71.3-1.1-1.1-0.8-0.9-0.8-0.7-0.70.4-0.7
Patch foraging water rate 24 sec0.40.62.81.0-1.70.60.5-0.2-0.30.1-0.7-0.1
Patch foraging water rate 6 sec0.20.31.50.0-0.60.60.60.20.00.5-1.20.4
Seeking ratio, delayed vs. immediate footshock2.63.25.2-1.42.31.61.62.02.01.9-1.41.7
Distance traveled before self-admin0.50.61.8-1.3-0.1-1.0-1.0-0.4-0.4-0.60.6-0.9
Distance traveled after self-admin0.20.20.4-0.6-0.5-0.5-0.6-0.4-0.2-0.40.2-0.4
Extensor digitorum longus weight1.76.923.94.9-4.3-0.4-0.5-2.6-2.2-2.00.8-1.5
Bone: elastic displacement0.10.10.50.7-0.30.40.30.0-0.10.1-0.20.1
Bone: elastic work0.91.26.22.5-1.60.80.6-0.5-0.6-0.2-0.3-0.1
Bone: endosteal estimation0.40.91.91.4-0.51.41.30.50.50.8-1.10.7
Bone: endosteal perimeter0.20.41.71.1-1.30.00.0-0.6-0.6-0.4-0.2-0.3
Epididymis fat weight0.00.00.1-0.1-0.3-0.0-0.2-0.3-0.2-0.2-0.10.1
Delta time in closed arm before/after self-admin1.41.31.90.1-1.4-1.2-1.1-1.2-1.1-1.21.1-1.3
Delta time in open arm before/after self-admin1.01.03.8-1.61.90.10.10.80.70.7-0.60.9
Diff in mean of infusions in LGA sessions0.10.10.20.4-0.5-0.2-0.1-0.3-0.3-0.20.0-0.2
Delay discount exponential model param3.03.45.81.40.92.42.41.81.51.9-2.11.7
Extinction: sum of active levers before priming0.30.30.5-0.40.0-0.7-0.7-0.5-0.7-0.60.5-0.5
Active lever presses in extinction session 60.10.10.10.3-0.10.20.20.10.10.2-0.40.3
Bone: final force1.32.15.82.4-2.1-0.4-0.4-1.4-1.5-1.21.1-1.3
Bone: final moment1.01.64.72.2-1.8-0.2-0.3-1.2-1.3-1.01.0-1.1
Food consumed during 24 hour testing period0.70.91.90.50.61.41.40.90.90.9-0.90.8
Glucose0.60.92.4-1.60.6-1.2-1.1-0.5-0.5-0.71.1-0.8
Heart weight0.50.81.8-0.0-1.4-0.7-0.8-1.0-1.0-0.90.7-0.8
Delay discount hyperbolic model param2.93.25.51.20.82.32.31.71.51.9-2.01.7
Intermittent access intake day 1-15 change0.51.02.11.4-0.21.41.20.70.70.8-0.81.0
Intermittent access intake escalation0.40.91.91.3-0.21.41.20.70.70.8-0.81.0
Intermittent access intake escalation 20.50.61.10.30.51.00.90.80.80.8-0.70.9
Intermitt. access day 1 inactive lever presses0.20.81.80.30.31.31.10.91.01.0-0.90.7
Intermitt. access day 15 inactive lever presses0.51.02.30.41.51.20.81.10.91.0-0.81.0
Intermitt. access escalation Index0.20.20.8-0.9-0.3-0.6-0.5-0.4-0.3-0.40.2-0.3
Intermittent access day 1 total infusions0.50.81.8-1.3-0.3-0.9-1.3-0.7-0.5-0.80.7-0.8
Intermittent access day 15 total infusions0.00.10.2-0.3-0.4-0.0-0.4-0.3-0.1-0.30.2-0.2
Intermittent access terminal intake (last 3 days)0.10.10.1-0.2-0.2-0.1-0.4-0.3-0.2-0.30.3-0.3
Intermittent access total infusions0.60.71.3-0.5-0.4-0.8-1.2-0.9-0.8-1.00.9-0.9
Intermittent access day 1 locomotion0.70.92.2-1.5-0.2-1.1-1.5-0.9-0.6-0.90.6-0.6
Intermittent access day 15 total locomotion0.20.31.0-0.6-1.0-0.4-0.8-0.5-0.2-0.3-0.1-0.2
Intermittent access total locomotion0.50.71.5-1.1-0.5-0.9-1.2-0.8-0.6-0.80.5-0.5
Intermittent access standard deviation0.81.63.20.81.11.81.51.31.31.3-1.01.2
Left kidney weight2.19.956.77.5-4.41.71.6-1.7-1.7-0.9-0.1-0.8
Right kidney weight1.98.548.87.0-4.01.41.4-1.6-1.7-1.00.1-0.9
Cocaine induced anxiety0.71.01.5-0.4-0.5-1.2-1.1-1.0-1.1-1.10.9-1.0
Post-drug Anxiety2.93.14.9-1.20.5-2.2-2.2-1.4-1.8-1.82.1-1.9
Baseline Anxiety0.70.91.8-0.91.4-0.9-0.9-0.2-0.5-0.61.3-0.9
Tail length3.212.442.36.5-5.4-0.6-0.6-3.3-3.3-2.71.9-2.5
Length with tail5.222.895.99.8-7.20.20.1-4.1-4.2-3.22.0-3.0
Length without tail2.68.451.47.2-3.51.91.9-1.2-1.4-0.6-0.2-0.6
Times rat made contact with spout0.70.81.41.0-1.1-0.4-0.4-0.9-1.2-0.90.8-1.1
Lifetime Intake0.40.51.0-0.70.1-0.6-1.0-0.6-0.5-0.70.8-0.7
Liver weight, left2.64.38.42.9-0.42.72.91.41.41.8-2.11.6
Liver weight, right0.61.16.22.5-1.10.90.9-0.1-0.30.1-0.60.2
Locomotor activity1.42.27.91.1-2.8-1.0-1.1-1.7-1.2-1.40.9-1.2
Locomotor testing distance0.20.30.80.9-0.90.50.50.10.30.4-0.70.3
Locomotor testing rearing0.71.42.5-0.10.71.11.21.21.21.4-1.61.3
Locomotion in novel chamber0.10.21.00.5-1.00.00.4-0.2-0.1-0.0-0.30.1
Locomotion in novel chamber post-restriction0.81.34.81.0-2.2-0.7-0.7-1.2-1.0-0.90.5-1.1
Fecal boli incidents, locomotor time 10.81.23.71.3-1.9-0.2-0.5-1.2-1.1-1.00.6-1.0
Change in fecal boli incidents, locomotor task0.10.10.70.20.90.20.40.50.20.30.10.1
Time >=10cm from walls, locomotor time 11.01.12.4-1.10.3-1.5-1.3-0.8-0.9-1.01.0-1.1
Bouts of movement, locomotor time 10.40.41.71.3-1.20.20.0-0.6-0.4-0.40.1-0.2
Total resting periods, locomotor time 10.40.51.71.2-1.30.1-0.2-0.7-0.5-0.50.3-0.3
Rest time, locomotor task time 10.50.62.51.6-1.10.2-0.1-0.7-0.8-0.60.3-0.6
Distance moved, locomotor task time 10.30.41.4-1.1-0.1-1.2-0.7-0.3-0.2-0.40.5-0.3
Vertical activity count, locomotor time 10.10.41.0-0.2-0.9-1.0-0.5-0.6-0.3-0.50.5-0.3
Time >=10cm from walls, locomotor time 21.11.72.50.9-0.9-1.3-1.2-1.4-1.6-1.41.2-1.4
Bouts of movement, locomotor time 20.20.31.31.1-1.2-0.10.0-0.5-0.3-0.3-0.10.1
Total resting periods, locomotor time 20.20.31.41.2-0.90.20.3-0.3-0.1-0.1-0.30.3
Rest time, locomotor task time 20.00.10.2-0.40.40.2-0.00.10.10.1-0.20.1
Distance moved, locomotor task time 20.10.10.10.4-0.20.10.30.20.40.20.10.2
Vertical activity count, locomotor time 20.40.52.41.5-1.40.60.5-0.20.1-0.00.00.1
Light reinforcement 10.92.23.9-1.3-0.3-2.0-1.9-1.3-1.5-1.51.6-1.4
Light reinforcement 20.10.20.4-0.40.60.30.30.60.60.5-0.30.5
Bone: marrow area0.51.02.01.3-0.41.41.40.60.60.9-1.10.7
Bone: maximum diameter0.40.83.81.9-1.30.20.1-0.8-0.8-0.60.2-0.5
Bone: maximum force0.81.34.72.2-1.9-0.1-0.2-1.1-1.0-0.80.5-0.8
Bone: maximum moment0.61.03.82.0-1.70.0-0.0-0.8-0.7-0.60.4-0.6
Mean time between licks in bursts0.41.13.6-1.91.30.20.21.01.20.9-0.80.9
Mean num. licks in bursts0.20.30.6-0.1-0.4-0.8-0.8-0.7-0.6-0.70.3-0.4
Cd content in liver0.70.71.1-0.8-1.0-1.1-1.1-0.9-0.4-0.80.7-0.7
Co content in liver2.93.35.00.50.82.22.21.82.12.0-1.92.0
Cu content in liver0.10.20.3-0.30.50.40.30.40.10.5-0.50.4
Fe content in liver0.70.81.70.3-1.3-0.9-0.9-1.2-1.2-0.90.2-0.6
K content in liver0.20.20.60.40.0-0.2-0.3-0.3-0.8-0.40.3-0.4
Mg content in liver0.20.21.21.1-0.10.40.3-0.1-0.5-0.00.1-0.1
Mn content in liver0.30.30.7-0.20.80.70.60.70.60.6-0.30.4
Na content in liver0.40.41.41.2-0.6-0.0-0.1-0.5-0.9-0.50.4-0.5
Rb content in liver0.70.95.0-2.21.3-0.6-0.60.40.20.2-0.20.2
Se content in liver2.42.95.11.3-1.3-1.6-1.7-2.0-2.3-1.91.4-1.6
Sr content in liver0.90.81.40.60.31.21.20.81.00.9-0.70.9
Zn content in liver1.61.85.72.4-0.51.81.70.70.41.0-1.31.0
Bone: minimum diameter0.00.00.0-0.1-0.00.00.0-0.00.1-0.00.1-0.0
Time in familiar zone, hab. session 12.12.02.6-0.21.61.41.41.61.61.5-1.31.5
Time in novel zone, hab. session 11.11.11.60.7-1.2-0.9-0.9-1.2-1.3-1.11.1-1.2
Total zone transitions, hab. session 10.71.04.0-2.00.1-1.2-1.2-0.5-0.5-0.60.8-0.7
Total locomotion distance, hab. session 10.50.71.4-1.2-0.0-1.2-1.1-0.7-0.6-0.80.7-0.7
Locomotion velocity, hab. session 10.81.13.4-1.80.1-1.4-1.4-0.7-0.6-0.80.9-0.8
Time in familiar zone, hab. session 20.10.10.30.20.50.20.20.30.30.2-0.00.2
Time in novel zone, hab. session 20.20.20.5-0.7-0.3-0.5-0.5-0.4-0.4-0.30.3-0.3
Total zone transitions, hab. session 20.10.20.40.2-0.6-0.3-0.3-0.4-0.3-0.40.6-0.4
Total locomotion distance, hab. session 20.10.10.4-0.6-0.1-0.5-0.5-0.3-0.1-0.30.4-0.3
Locomotion velocity, hab. session 20.10.10.4-0.6-0.1-0.5-0.5-0.2-0.0-0.30.4-0.3
Novel to familiar place preference ratio0.10.10.3-0.3-0.3-0.4-0.4-0.3-0.3-0.40.6-0.4
Novelty place preference0.10.10.4-0.6-0.1-0.4-0.4-0.2-0.2-0.30.5-0.3
Time in novel zone, NPP test0.10.10.3-0.4-0.2-0.4-0.4-0.3-0.3-0.40.5-0.3
Total zone transitions, NPP test0.20.30.4-0.0-0.6-0.6-0.6-0.6-0.6-0.60.6-0.6
Total locomotion distance, NPP test1.11.52.3-0.5-0.8-1.5-1.5-1.3-1.3-1.31.1-1.2
Locomotion velocity, NPP test1.11.52.2-0.5-1.1-1.5-1.5-1.3-1.3-1.31.1-1.2
Intraocular pressure0.30.52.01.4-1.00.60.5-0.20.10.1-0.80.3
Delta distance traveled before/after self-admin0.40.40.80.6-0.00.90.80.50.60.6-0.60.8
Delta ambulatory time before/after self-admin0.50.60.9-0.10.70.80.80.80.90.8-0.71.0
Parametrial fat weight0.00.10.60.80.30.10.10.0-0.2-0.10.2-0.1
Pavlov. Cond. lever latency0.70.84.72.2-0.81.01.00.1-0.20.2-0.30.2
Pavlov. Cond. magazine entry latency0.60.71.30.4-1.1-0.8-0.8-1.0-0.6-0.90.8-0.8
Pavlov. Cond. change in total contacts1.41.52.5-0.6-0.4-1.5-1.6-1.2-1.0-1.31.5-1.2
Pavlov. Cond. index score0.40.51.0-0.5-0.3-1.0-1.0-0.7-0.5-0.80.7-0.7
Pavlov. Cond. latency score0.60.71.4-0.8-0.2-1.2-1.2-0.8-0.5-0.90.8-0.8
Pavlov. Cond. lever contacts0.60.73.2-1.80.7-1.0-1.0-0.20.0-0.40.5-0.3
Pavlov. Cond. magazine entry number0.70.91.5-0.31.21.01.01.10.81.0-0.80.9
Pavlov. Cond. intertrial magazine entries0.50.61.9-1.41.00.30.40.80.50.7-0.60.6
Pavlov. Cond. lever-magazine prob. diff.0.30.40.8-0.3-0.3-0.9-0.9-0.7-0.4-0.70.6-0.6
Pavlov. Cond. response bias0.50.60.9-0.0-0.9-0.9-0.9-0.9-0.7-0.90.6-0.7
Pavlov. Cond. lever latency1.31.72.50.60.91.41.51.41.61.4-1.21.5
Pavlov. Cond. magazine entry latency1.92.34.3-1.5-0.3-1.9-2.1-1.4-1.3-1.51.6-1.4
Pavlov. Cond. change in total contacts0.71.11.7-1.0-0.8-1.2-1.3-1.1-1.1-1.00.9-1.1
Pavlov. Cond. index score1.52.03.3-1.4-0.6-1.7-1.8-1.3-1.3-1.41.3-1.4
Pavlov. Cond. latency score1.41.93.2-1.4-0.5-1.7-1.8-1.3-1.3-1.41.3-1.3
Pavlov. Cond. lever contacts1.52.12.9-0.8-0.9-1.7-1.7-1.5-1.7-1.51.3-1.6
Pavlov. Cond. magazine entry number1.41.73.01.70.21.61.71.11.01.2-1.31.2
Pavlov. Cond. intertrial magazine entries0.10.20.91.0-0.80.30.3-0.10.00.0-0.20.0
Pavlov. Cond. lever-magazine prob. diff.1.72.33.8-1.5-0.7-1.8-1.9-1.4-1.4-1.51.5-1.5
Pavlov. Cond. response bias2.22.94.7-1.4-1.0-2.1-2.2-1.7-1.8-1.71.5-1.7
Time in closed arm before self-admin0.30.41.71.3-1.00.60.6-0.1-0.00.1-0.20.3
Time in closed arm after self-admin0.70.73.80.7-2.0-0.2-0.2-0.8-0.6-0.60.5-0.5
Time in open arm before self-admin0.80.91.4-0.4-1.0-1.1-1.1-0.9-0.7-0.90.9-1.2
Time in open arm after self-admin0.20.21.2-0.81.1-0.2-0.30.20.10.1-0.00.2
Bone: periosteal estimation0.51.14.32.1-1.70.10.0-1.0-0.9-0.70.4-0.7
Bone: periosteal perimeter1.01.73.00.8-1.7-1.1-1.1-1.6-1.6-1.40.9-1.3
Bone: post-yield work0.10.10.30.4-0.40.10.2-0.00.10.1-0.60.4
Progressive ratio test 1 active lever presses0.50.61.11.0-1.1-0.1-0.4-0.8-0.7-0.80.7-0.7
Progressive ratio test 1 breakpoint0.50.61.11.1-1.1-0.2-0.5-0.9-0.7-0.80.7-0.8
Progressive ratio test 1 inactive lever presses0.30.51.40.5-0.41.20.80.50.70.7-0.80.5
Progressive ratio test 2 active lever presses0.30.31.30.7-1.1-0.0-0.4-0.6-0.4-0.50.4-0.5
Progressive ratio test 2 breakpoint0.30.31.20.6-1.1-0.0-0.4-0.6-0.4-0.50.4-0.5
Progressive ratio test 2 inactive lever presses0.61.02.31.5-1.01.40.90.30.60.7-1.10.7
Incentive Sensitization - Responses0.00.00.1-0.20.10.1-0.00.20.10.2-0.10.0
Incentive Sensitization - Breakpoint0.00.00.1-0.40.10.1-0.00.20.10.2-0.10.1
Sum of active levers in priming session hrs 5-60.10.10.40.50.2-0.1-0.2-0.3-0.6-0.30.3-0.5
Progressive ratio0.20.31.1-1.00.7-0.10.20.50.60.4-0.10.6
Food seeking constrained by brief footshock4.15.06.3-0.92.42.12.22.52.52.4-2.32.4
Seeking ratio, punishment vs. effort0.30.41.21.1-0.11.10.70.30.30.5-0.70.1
Retroperitoneal fat weight0.20.81.60.30.2-0.8-0.9-0.9-1.3-1.11.0-1.0
Reaction time number correct0.50.91.90.7-0.11.41.30.80.71.0-1.20.8
Reaction time mean minus median3.17.710.80.1-2.4-3.2-3.3-3.1-2.8-3.12.7-2.8
Reaction time mean minus median AUC1.02.64.5-0.9-1.2-2.1-2.1-1.7-1.4-1.71.4-1.5
Reaction time num false alarms1.11.62.6-1.0-1.1-1.5-1.6-1.3-1.0-1.31.2-1.2
Reaction time num false alarms AUC0.60.91.5-0.7-1.0-1.1-1.2-1.0-0.7-1.00.7-0.8
Reaction time trials correct on left0.50.91.90.7-0.11.41.30.80.71.0-1.20.8
Reaction time trials on left0.40.81.70.7-0.11.31.20.70.70.9-1.10.7
Reaction time mean2.13.36.1-2.00.1-2.4-2.5-1.4-1.2-1.82.1-1.6
Reaction time mean AUC1.93.05.7-2.00.2-2.4-2.4-1.3-1.1-1.61.9-1.5
Median of all reaction times1.41.95.7-2.41.1-1.7-1.7-0.5-0.4-1.01.6-0.9
Reaction time omissions0.91.32.6-1.0-0.4-1.5-1.6-1.1-0.9-1.21.2-1.1
Reaction time false alarm rate1.41.93.4-1.0-1.0-1.8-1.8-1.4-1.1-1.51.3-1.2
Reaction time premature initiation rate0.91.32.2-0.4-1.1-1.5-1.3-1.3-1.0-1.21.1-1.0
Reaction time premature initiations0.20.40.8-0.1-0.9-0.7-0.6-0.7-0.5-0.60.5-0.5
Std. dev. reaction times2.64.88.1-0.8-1.2-2.8-2.9-2.3-2.0-2.42.3-2.2
Reaction time trials completed0.40.81.70.7-0.11.31.20.70.70.9-1.10.7
Reaction time trials AUC0.40.81.60.4-0.01.31.10.80.70.9-1.20.8
Run reversals in cocaine runway, females0.50.51.3-0.91.10.50.40.80.50.7-0.60.7
Run reversals in cocaine runway, males0.30.30.6-0.7-0.00.30.40.50.70.6-0.70.8
Latency to leave start box in cocaine runway0.10.10.50.10.1-0.3-0.3-0.3-0.4-0.40.7-0.4
Latency to leave start box in cocaine runway, F0.20.21.11.10.10.10.30.0-0.2-0.10.5-0.3
Latency to leave start box in cocaine runway, M0.20.20.8-0.90.1-0.3-0.5-0.2-0.2-0.30.2-0.1
Std. dev. time between licks in bursts0.20.20.8-0.1-0.9-0.5-0.5-0.5-0.1-0.40.1-0.1
Total sessions with >9 infusions0.10.10.7-0.30.80.2-0.00.30.30.2-0.00.2
Short access day 1 total inactive lever presses0.91.22.40.50.71.61.31.11.11.1-1.21.1
Short access day 10 total inactive lever presses1.53.77.12.10.72.72.41.71.71.9-1.91.7
Short access day 1 total infusions0.60.72.4-0.81.60.70.40.90.90.7-0.50.7
Short access day 10 total infusions0.10.20.6-0.60.8-0.0-0.40.20.30.2-0.30.2
Short access total infusions0.20.21.5-0.71.2-0.0-0.30.20.20.00.20.0
Short access day 1 locomotion1.01.32.7-1.0-0.6-1.3-1.6-1.1-1.0-1.21.2-0.9
Short access day 10 total locomotion0.61.01.8-0.10.61.20.91.01.11.1-1.31.3
Short access total locomotion0.30.31.0-1.00.4-0.6-1.0-0.2-0.1-0.30.3-0.2
One hour access (0.3 mA shock)0.30.40.90.3-1.00.90.70.20.40.4-0.60.4
Compulsive drug intake0.70.93.0-1.71.20.20.31.00.90.8-0.50.6
One hour access (shock baseline)0.81.23.91.0-2.0-0.5-0.7-1.3-1.1-1.00.7-0.9
Social response proportion5.56.310.72.4-3.3-1.8-1.7-2.7-2.7-2.62.5-2.6
Social responses1.21.55.01.2-2.2-0.8-0.8-1.4-1.1-1.10.7-1.0
Social time1.01.35.3-2.30.3-1.4-1.4-0.5-0.2-0.71.1-0.7
Soleus weight0.30.94.22.0-1.60.40.5-0.5-0.5-0.1-0.70.1
Bone: stiffness1.11.73.20.7-1.8-1.2-1.2-1.5-1.4-1.41.2-1.3
Tibialis anterior weight2.89.429.45.4-4.7-0.8-0.9-3.1-3.0-2.51.5-2.2
Time to tail flick, vehicle, before self-admin1.91.93.4-0.7-0.2-1.7-1.7-1.2-1.4-1.51.8-1.5
Time to tail flick, vehicle, after self-admin0.40.51.0-0.2-0.6-1.0-0.8-0.7-0.7-0.70.7-0.7
Time to tail flick, test, before self-admin0.40.42.61.6-0.90.20.4-0.3-0.4-0.20.3-0.2
Time to tail flick, test, after self-admin0.30.30.6-0.30.1-0.6-0.6-0.4-0.4-0.50.8-0.5
Delta time to tail flick, vehicle, before/after SA0.10.10.4-0.30.10.20.30.30.40.4-0.60.5
Delta time to tail flick, test, before/after SA0.40.41.6-1.31.00.0-0.00.50.70.4-0.40.4
Tibia length1.23.420.84.6-2.20.70.6-1.1-0.8-0.91.0-0.8
Ambulatory time before self-admin0.50.71.1-0.9-0.6-1.1-1.1-0.7-0.6-0.70.5-1.0
Ambulatory time after self-admin0.10.10.5-0.7-0.2-0.4-0.5-0.2-0.1-0.20.0-0.2
Bone: tissue strength2.32.33.20.21.21.81.81.61.51.7-1.61.6
Total heroin consumption1.41.74.5-2.10.4-1.8-1.8-0.8-0.8-1.00.9-0.9
Bone: trabecular number0.81.26.62.6-1.21.01.0-0.1-0.50.2-0.80.2
Bone: trabecular spacing0.91.34.5-2.11.70.0-0.00.91.20.7-0.40.9
Bone: trabecular thickness1.01.26.42.5-1.60.50.5-0.7-0.8-0.3-0.5-0.1
Bone: trabecular tissue density5.88.611.30.1-2.2-3.4-3.3-3.2-2.9-3.33.3-3.2
Water consumed over 24 hours0.60.84.12.0-0.81.11.10.0-0.20.2-0.3-0.1
Number of responses in last shaping day0.10.10.4-0.50.6-0.0-0.20.10.10.00.00.1