Bin2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Bin2	0.54	0.18	0.0e+00	0.16	0.16	0.17	0.17	5.8e-18	1.6e-17	1.3e-18	1.4e-18
2	Adipose	gene expression	Bin2	0.03	0.03	1.1e-03	0.03	0.02	0.01	0.01	6.4e-04	2.5e-03	6.8e-03	7.6e-03
3	IC	gene expression	Bin2	0.13	0.08	1.2e-03	0.07	0.06	0.07	0.05	7.9e-04	1.8e-03	9.6e-04	3.0e-03
4	pVTA	intron excision ratio	chr7_133639481_133646864	0.35	0.19	9.5e-04	0.03	0.02	0.01	0.03	8.5e-04	5.4e-03	3.1e-02	4.1e-03
5	NAcc	gene expression	Bin2	0.14	0.06	4.4e-16	0.12	0.12	0.12	0.12	1.3e-17	3.4e-17	9.5e-18	6.6e-18
6	Brain	gene expression	Bin2	0.2	0.09	1.0e-13	0.16	0.16	0.15	0.16	7.6e-15	9.0e-15	3.9e-14	1.0e-14
7	PL	gene expression	Bin2	0.11	0.06	1.2e-07	0.09	0.08	0.09	0.09	6.5e-10	6.1e-09	1.3e-09	1.4e-09
8	pVTA	gene expression	Bin2	0.17	0.09	1.3e-09	0.12	0.12	0.13	0.13	1.1e-09	4.6e-10	1.2e-10	1.2e-10
9	BLA	gene expression	Bin2	0.14	0.08	4.7e-04	0.07	0.05	0.03	0.06	8.8e-05	7.7e-04	7.1e-03	3.4e-04
10	pVTA	intron excision ratio	chr7_133652242_133652838	0.31	0.19	4.8e-04	0.03	0.03	0.02	0.03	4.2e-03	3.2e-03	1.5e-02	1.9e-03
11	IL	gene expression	Bin2	0.34	0.17	6.3e-05	0.22	0.23	0.29	0.22	4.2e-06	2.8e-06	1.3e-07	6.0e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	4.8	8.9	11.2	-3.2	-3.2	-3.3	3.3	3.3	-3.2	-3.2	-3.3	-3.0	0.7	-1.4
Area under the delay curve	0.2	0.3	1.0	-1.0	-0.9	-0.5	0.6	0.5	-0.6	-0.6	-0.5	-0.2	0.1	-0.0
BMI with tail	3.5	12.2	28.1	-4.8	-5.3	-3.5	3.3	3.3	-3.3	-3.3	-3.3	-3.3	2.1	-0.3
BMI without tail	1.0	5.1	8.0	-2.8	-2.7	-2.4	2.6	2.5	-2.2	-2.2	-2.3	-2.2	1.4	-0.6
Body weight	4.8	21.0	32.3	-5.7	-5.6	-4.9	4.9	4.9	-4.8	-4.7	-4.8	-4.6	1.5	-1.8
Weight adjusted by age	0.3	0.9	3.0	-0.5	-0.9	0.8	-0.6	-0.6	0.8	0.8	0.8	0.7	1.5	1.7
Bone surface	6.2	12.2	16.7	-4.0	-4.1	-3.8	3.7	3.7	-3.8	-3.8	-3.8	-3.7	0.6	-1.7
Bone volume	5.2	10.4	14.0	-3.7	-3.7	-3.5	3.5	3.5	-3.5	-3.4	-3.5	-3.3	1.1	-1.4
Breakpoint value in progressive ratio session	0.4	0.7	1.1	-0.8	-0.8	-1.0	0.9	1.0	-0.9	-0.9	-1.0	-0.7	-0.1	-0.8
Number of licking bursts	0.9	2.6	3.8	2.0	1.8	1.7	-1.7	-1.7	1.8	1.8	1.7	1.7	0.1	0.7
Context. condit. distance diff. score	1.0	1.2	2.0	-1.1	-1.1	-1.1	1.1	1.2	-1.2	-1.3	-1.1	-1.4	-0.2	-0.9
Locomotion velocity, session 1	2.3	2.6	5.6	2.4	1.7	1.5	-1.5	-1.5	1.8	1.6	1.5	1.7	-1.3	0.8
Locomotion distance, session 1	2.6	3.3	4.9	2.2	1.8	1.9	-2.0	-2.0	2.0	1.9	1.8	2.0	-0.3	1.3
Locomotion velocity, session 2	0.2	0.3	0.9	0.9	0.6	0.3	-0.3	-0.4	0.4	0.4	0.3	0.5	-1.0	0.1
Locomotion distance, session 2	3.1	4.4	7.7	2.8	2.5	2.2	-2.2	-2.2	2.1	2.2	2.1	2.3	-0.6	1.2
Locomotion velocity, session 3	1.9	2.2	6.2	2.4	2.5	1.2	-1.1	-1.1	1.3	1.2	1.1	1.1	-1.8	-0.6
Locomotion distance, session 3	0.9	1.0	3.2	1.2	1.8	-0.5	0.6	0.6	-0.3	-0.3	-0.5	-0.3	-1.8	-1.5
Stereotopy head waving bouts, day 3	2.4	2.8	4.0	1.0	0.6	1.8	-1.9	-1.9	1.9	2.0	1.9	1.8	1.5	1.8
Stereotopy head waving duration, day 3	1.0	1.2	1.8	1.1	0.9	1.2	-1.3	-1.3	1.3	1.3	1.2	1.2	0.4	0.6
Locomotion velocity, session 7	0.6	0.7	3.2	1.2	1.8	0.1	-0.0	-0.0	0.2	0.1	0.0	0.0	-1.2	-1.2
Locomotion distance, session 7	1.2	1.5	5.3	1.9	2.3	0.5	-0.4	-0.4	0.6	0.6	0.4	0.4	-2.2	-1.1
Stereotopy head waving bouts, day 7	1.1	1.3	5.9	-0.8	-1.0	0.7	-0.8	-0.8	0.7	0.6	0.8	0.7	2.4	1.7
Stereotopy head waving duration, day 7	0.7	0.8	3.7	-0.8	-1.1	0.5	-0.6	-0.6	0.4	0.4	0.6	0.5	1.9	1.3
Locomotion velocity, session 8	0.2	0.2	0.4	0.4	0.4	0.6	-0.6	-0.6	0.4	0.4	0.6	0.3	-0.1	0.2
Locomotion distance, session 8	0.3	0.4	1.4	1.1	0.9	0.6	-0.5	-0.4	0.3	0.3	0.4	0.3	-1.2	-0.1
Degree of sensitization distance	0.5	0.5	0.9	0.2	-0.2	0.9	-1.0	-0.9	0.7	0.7	0.8	0.7	0.5	0.8
Degree of sensitization stereotypy	0.8	0.9	4.0	-1.1	-1.4	0.4	-0.4	-0.4	0.2	0.1	0.4	0.2	2.0	1.4
Conditioned locomotion	0.1	0.2	0.8	0.9	0.8	0.2	-0.0	-0.0	0.1	0.1	0.1	0.1	-0.3	-0.4
Cocaine response after cond. corrected	0.4	0.6	1.0	0.4	0.4	1.0	-0.8	-0.8	0.9	0.9	1.0	0.8	0.4	0.8
Cocaine response after cond. not corrected	0.2	0.3	0.5	0.5	0.6	0.7	-0.5	-0.6	0.6	0.6	0.7	0.6	0.1	0.4
Cocaine response before conditioning	0.3	0.4	1.7	0.8	1.1	-0.2	0.2	0.2	-0.1	-0.1	-0.3	-0.1	-1.3	-0.9
Saline control response	0.6	0.8	1.4	-0.4	0.2	-1.0	1.2	1.1	-0.8	-0.9	-1.0	-0.9	-0.2	-1.1
Bone: connectivity density	3.1	4.9	6.5	-2.2	-2.4	-2.5	2.5	2.4	-2.4	-2.4	-2.5	-2.3	-0.3	-1.2
Bone: cortical apparent density	2.1	3.3	4.6	0.8	0.6	2.1	-2.0	-2.0	1.9	1.9	2.1	2.0	1.7	2.2
Bone: cortical area	4.3	7.1	10.3	-3.2	-3.0	-2.9	2.9	2.9	-2.7	-2.7	-3.0	-2.7	0.8	-1.3
Bone: cortical porosity	1.2	1.4	1.9	-0.5	-0.4	-1.3	1.3	1.3	-1.2	-1.4	-1.4	-1.2	-0.9	-1.4
Bone: cortical porosity	1.1	1.2	2.0	-0.3	-0.1	-1.3	1.2	1.2	-1.1	-1.3	-1.3	-1.1	-0.9	-1.4
Bone: cortical thickness	1.4	2.3	3.5	-1.9	-1.9	-1.6	1.7	1.6	-1.4	-1.5	-1.7	-1.5	0.6	-0.7
Bone: cortical thickness	0.3	0.4	0.7	0.2	0.3	-0.8	0.8	0.7	-0.3	-0.4	-0.8	-0.5	-0.7	-0.7
Bone: cortical tissue density	2.1	3.4	4.7	0.9	0.7	2.1	-2.1	-2.1	1.9	1.9	2.2	2.0	1.6	2.1
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	-0.3	-0.4	0.2	-0.1	-0.1	0.1	0.0	0.0	0.0	0.1	0.2
Condit. Reinf. active-inactive response ratio	0.7	0.7	0.9	-0.9	-0.7	-0.9	0.9	0.9	-0.8	-0.9	-1.0	-0.9	-0.4	-0.7
Condit. Reinf. active responses	0.5	0.7	1.0	0.8	0.3	1.0	-0.9	-0.9	0.9	0.9	0.9	0.9	0.1	0.8
Condit. Reinf. inactive responses	3.4	4.4	6.1	2.5	1.7	2.2	-2.2	-2.2	2.3	2.4	2.2	2.3	0.3	1.6
Incentive salience index mean	0.1	0.1	0.6	-0.5	-0.8	0.1	-0.0	-0.0	0.1	0.1	-0.0	0.1	0.4	0.6
Condit. Reinf. lever presses	0.3	0.4	1.6	-0.5	-1.2	0.2	-0.2	-0.2	0.2	0.3	0.1	0.3	1.0	1.3
Condit. Reinf. active minus inactive responses	0.3	0.5	1.8	-1.2	-1.3	-0.5	0.4	0.4	-0.3	-0.4	-0.5	-0.4	0.8	0.3
Condit. Reinf. active-inactive response ratio	0.2	0.4	1.0	-1.0	-1.0	-0.6	0.6	0.6	-0.4	-0.4	-0.6	-0.5	0.4	-0.0
Condit. Reinf. active responses	0.1	0.2	0.7	-0.9	-0.7	-0.2	0.1	0.1	-0.1	-0.1	-0.1	-0.1	0.8	0.4
Condit. Reinf. inactive responses	0.2	0.3	0.5	0.3	0.4	0.6	-0.7	-0.7	0.4	0.5	0.7	0.5	0.4	0.5
Condit. Reinf. lever presses	0.4	0.6	1.8	-0.1	0.3	-0.8	0.8	0.8	-0.6	-0.6	-0.8	-0.6	-1.2	-1.3
Condit. Reinf. lever reinforcers received	0.0	0.0	0.3	-0.5	-0.4	-0.2	0.1	0.1	-0.1	-0.1	-0.1	-0.1	0.2	0.1
Conditioned reinforcement - actives	0.1	0.4	1.6	1.0	1.3	0.4	-0.3	-0.3	0.4	0.6	0.4	0.8	-0.6	-0.2
Conditioned reinforcement - inactives	0.9	2.3	6.2	2.3	2.5	1.0	-1.3	-1.3	1.5	1.6	1.0	1.6	-1.1	-0.2
Conditioned locomotion	0.1	0.2	0.7	0.6	0.9	-0.0	-0.0	-0.0	-0.0	0.1	-0.1	0.3	-0.9	-0.7
Patch foraging indifference point 0 sec	0.5	1.5	6.0	1.8	2.4	0.9	-1.0	-1.0	1.0	0.9	0.8	0.8	-0.9	-0.4
Patch foraging indifference point AUC	0.8	1.9	2.8	1.4	0.9	1.5	-1.4	-1.5	1.7	1.7	1.5	1.6	0.6	1.1
Delay disc. indifference point, 0s delay	0.9	1.0	2.5	-1.6	-1.2	-0.8	1.0	1.1	-1.2	-1.3	-0.9	-0.6	-0.2	-0.4
Delay disc. indifference point, 16s delay	0.4	0.6	0.9	-0.9	-0.8	-0.9	0.8	0.8	-0.8	-0.8	-0.9	-0.6	-0.2	-0.4
Delay disc. indifference point, 2s delay	1.2	1.3	5.7	-1.4	-1.4	0.6	-0.3	-0.3	0.2	0.2	0.6	0.6	2.4	1.8
Delay disc. indifference point, 24s delay	0.0	0.1	0.4	-0.3	-0.6	-0.2	0.2	0.2	-0.1	-0.1	-0.2	0.1	0.0	0.2
Delay disc. indifference point, 4s delay	0.4	0.5	1.0	-1.0	-1.0	-0.7	0.8	0.8	-0.6	-0.7	-0.7	-0.1	0.3	-0.0
Delay disc. indifference point, 8s delay	0.7	1.2	1.8	-1.2	-0.8	-1.1	1.1	1.2	-1.3	-1.3	-1.2	-0.9	-0.5	-1.0
Indifference point function ln k	1.5	4.4	6.9	-2.6	-2.4	-2.3	2.2	2.2	-2.3	-2.3	-2.3	-2.2	0.2	-0.8
Indifference point function log k	1.5	4.4	6.9	-2.6	-2.4	-2.3	2.2	2.2	-2.3	-2.3	-2.3	-2.2	0.2	-0.8
Patch foraging total patch changes 0 sec	0.5	1.3	6.1	1.8	2.5	0.7	-0.7	-0.7	0.8	0.8	0.6	0.6	-1.1	-0.7
Patch foraging total patch changes 12 sec	2.3	3.0	6.7	2.6	2.2	1.7	-1.7	-1.7	1.9	1.9	1.7	1.7	-0.4	0.6
Patch foraging total patch changes 18 sec	1.3	3.0	6.8	2.6	2.5	1.6	-1.6	-1.6	1.8	1.8	1.6	1.7	-0.7	0.2
Patch foraging total patch changes 24 sec	0.4	1.4	4.2	2.0	1.9	1.0	-0.8	-0.9	1.2	1.2	0.9	1.0	-0.4	-0.0
Patch foraging total patch changes 6 sec	2.3	3.9	7.6	2.7	2.7	2.0	-2.0	-2.0	2.1	2.1	1.9	1.9	-0.7	0.5
Patch foraging time to switch 0 sec	0.4	1.7	2.2	1.2	1.5	1.5	-1.4	-1.4	1.4	1.3	1.5	1.4	0.4	0.9
Patch foraging water rate 0 sec	1.0	3.9	5.2	-2.1	-2.3	-2.1	2.1	2.1	-2.2	-2.0	-2.1	-2.1	0.0	-1.3
Patch foraging water rate 12 sec	0.7	2.8	4.0	-1.6	-1.8	-1.7	1.8	1.8	-2.0	-1.9	-1.8	-1.8	-0.5	-1.0
Patch foraging water rate 18 sec	0.0	0.1	0.2	-0.1	-0.4	-0.1	0.2	0.2	-0.4	-0.3	-0.1	-0.3	-0.2	-0.1
Patch foraging water rate 24 sec	1.6	2.2	4.4	-1.8	-2.1	-1.4	1.4	1.5	-1.8	-1.6	-1.4	-1.7	0.4	-0.6
Patch foraging water rate 6 sec	3.9	5.8	7.8	-2.8	-2.8	-2.5	2.6	2.6	-2.7	-2.6	-2.5	-2.6	-0.2	-1.5
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	1.0	-1.0	-1.0	-0.5	0.3	0.4	-0.6	-0.7	-0.5	-0.4	-0.2	0.1
Distance traveled before self-admin	0.6	1.3	2.2	1.5	1.5	1.1	-1.3	-1.3	1.0	1.0	1.2	1.2	-0.5	0.1
Distance traveled after self-admin	0.5	0.8	4.1	1.0	1.0	-0.2	0.2	0.2	-0.4	-0.4	-0.2	-0.4	-2.0	-1.4
Extensor digitorum longus weight	1.9	7.8	32.6	-4.1	-4.9	-0.9	0.8	0.8	-0.8	-0.8	-0.7	-0.9	5.7	2.6
Bone: elastic displacement	3.0	3.8	8.2	2.8	2.9	1.8	-1.9	-1.8	1.6	1.6	1.8	1.6	-2.1	-0.2
Bone: elastic work	0.4	0.5	3.5	0.6	0.7	-0.2	0.2	0.2	-0.2	-0.3	-0.3	-0.3	-1.9	-1.1
Bone: endosteal estimation	4.8	11.8	14.8	-3.8	-3.4	-3.9	3.8	3.8	-3.8	-3.7	-3.8	-3.6	0.5	-1.9
Bone: endosteal perimeter	3.8	9.3	13.0	-3.6	-3.2	-3.4	3.4	3.3	-3.2	-3.2	-3.4	-3.1	1.1	-1.5
Epididymis fat weight	1.3	6.4	9.5	-1.1	-0.9	-2.7	2.8	2.7	-2.6	-2.6	-2.8	-2.6	-2.9	-3.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.2	-0.2	-0.5	0.3	0.4	-0.5	-0.5	-0.5	-0.5	-0.2	-0.6
Delta time in open arm before/after self-admin	0.6	0.7	2.9	1.1	1.1	-0.2	0.3	0.3	-0.2	-0.2	-0.2	-0.5	-1.7	-1.2
Diff in mean of infusions in LGA sessions	0.3	0.6	1.6	-1.2	-1.3	-0.6	0.4	0.4	-0.6	-0.6	-0.5	-0.7	1.1	0.3
Delay discount exponential model param	0.2	0.3	0.9	0.9	0.9	0.4	-0.5	-0.5	0.5	0.5	0.4	0.1	-0.2	-0.1
Extinction: sum of active levers before priming	0.8	1.2	3.9	-1.7	-2.0	-1.0	0.9	0.9	-1.0	-1.0	-0.8	-0.9	0.8	0.3
Active lever presses in extinction session 6	0.7	0.7	1.7	-0.1	-0.2	-1.1	1.3	1.2	-0.6	-0.6	-0.8	-0.5	-0.9	-1.0
Bone: final force	8.6	14.1	19.0	-4.4	-4.2	-4.0	4.1	4.1	-4.1	-4.1	-4.0	-3.9	0.0	-2.1
Bone: final moment	10.1	16.3	21.1	-4.6	-4.4	-4.4	4.4	4.4	-4.4	-4.4	-4.4	-4.2	-0.0	-2.4
Food consumed during 24 hour testing period	1.5	3.0	4.2	-1.6	-1.8	-1.8	1.7	1.8	-2.1	-2.1	-1.8	-1.9	-1.1	-1.3
Glucose	0.1	0.1	0.4	0.6	0.3	0.2	-0.2	-0.2	0.4	0.3	0.2	0.3	-0.3	-0.0
Heart weight	1.5	2.5	3.3	-1.2	-0.9	-1.8	1.8	1.8	-1.7	-1.7	-1.8	-1.7	-0.8	-1.7
Delay discount hyperbolic model param	0.2	0.2	0.9	1.0	0.8	0.2	-0.4	-0.4	0.4	0.4	0.3	0.0	-0.4	-0.2
Intermittent access intake day 1-15 change	0.3	1.5	2.0	-0.4	-0.4	-1.4	1.4	1.4	-1.4	-1.4	-1.4	-1.2	-1.1	-1.3
Intermittent access intake escalation	0.3	1.7	2.4	-0.9	-0.8	-1.5	1.6	1.6	-1.6	-1.5	-1.5	-1.3	-0.6	-1.1
Intermittent access intake escalation 2	0.6	1.1	1.5	-0.7	-0.4	-1.1	0.9	1.0	-1.2	-1.2	-1.1	-1.2	-1.0	-1.2
Intermitt. access day 1 inactive lever presses	0.0	0.5	1.0	0.7	0.3	0.8	-0.8	-0.8	0.9	0.8	0.8	1.0	0.3	0.7
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.3	0.4	0.5	-0.1	0.5	0.4	0.2	0.1	-0.1	-0.2	-0.3	-0.2
Intermitt. access escalation Index	0.5	1.7	4.0	0.1	-0.1	1.3	-1.5	-1.5	1.2	1.2	1.4	1.2	1.4	2.0
Intermittent access day 1 total infusions	0.2	0.6	2.7	1.0	1.6	0.7	-0.6	-0.6	0.6	0.8	0.7	0.7	-0.5	-0.3
Intermittent access day 15 total infusions	0.1	0.2	0.8	0.3	0.9	-0.1	0.2	0.2	-0.3	-0.2	-0.1	-0.2	-0.5	-0.8
Intermittent access terminal intake (last 3 days)	0.1	0.2	1.0	0.3	1.0	0.0	-0.1	-0.1	-0.2	-0.1	0.0	-0.0	-0.4	-0.7
Intermittent access total infusions	0.2	0.3	1.7	0.5	1.3	0.3	-0.3	-0.3	0.0	0.2	0.3	0.3	-0.4	-0.7
Intermittent access day 1 locomotion	0.3	0.6	2.6	1.2	1.6	0.3	-0.3	-0.4	0.4	0.6	0.3	0.6	-1.0	-0.5
Intermittent access day 15 total locomotion	0.5	1.7	4.2	0.6	1.1	-1.4	1.4	1.3	-1.0	-0.9	-1.4	-0.6	-2.1	-2.0
Intermittent access total locomotion	0.8	1.0	4.1	1.7	2.0	0.1	-0.2	-0.2	0.4	0.5	0.1	0.8	-1.4	-0.9
Intermittent access standard deviation	0.3	1.4	3.7	-0.1	0.5	-0.9	0.8	0.9	-1.2	-1.1	-0.9	-1.3	-1.9	-1.9
Left kidney weight	0.9	7.3	10.5	-3.2	-3.0	-2.9	3.2	3.1	-2.8	-2.9	-2.9	-2.6	0.4	-1.2
Right kidney weight	2.1	14.8	25.1	-5.0	-5.0	-3.9	4.1	4.1	-4.0	-4.0	-3.9	-3.7	1.2	-1.2
Cocaine induced anxiety	1.2	3.1	4.3	-1.9	-1.8	-2.1	1.9	1.9	-2.0	-2.0	-2.0	-1.8	0.0	-1.1
Post-drug Anxiety	3.7	4.2	6.4	-2.0	-1.8	-2.5	2.2	2.2	-2.2	-2.3	-2.4	-2.0	-0.4	-1.6
Baseline Anxiety	0.0	0.0	0.0	-0.2	-0.2	-0.0	0.0	0.0	0.1	0.0	-0.1	0.1	0.2	0.2
Tail length	0.3	1.6	3.0	-0.7	0.2	-1.4	1.7	1.6	-1.2	-1.2	-1.4	-1.3	-0.2	-1.6
Length with tail	1.5	6.5	8.8	-2.8	-2.3	-2.8	3.0	2.9	-2.8	-2.8	-2.8	-2.7	0.4	-1.7
Length without tail	2.0	10.5	16.2	-3.9	-4.0	-3.5	3.3	3.3	-3.5	-3.5	-3.4	-3.3	0.4	-1.5
Times rat made contact with spout	0.4	0.4	0.9	-0.3	-0.4	-0.7	0.5	0.6	-0.7	-0.7	-0.7	-0.6	-0.9	-0.7
Lifetime Intake	0.5	0.6	3.2	0.9	1.8	0.4	-0.4	-0.4	0.1	0.3	0.4	0.4	-0.9	-1.0
Liver weight, left	8.4	14.4	19.0	-4.4	-4.1	-4.2	4.2	4.1	-4.1	-4.2	-4.1	-3.9	0.1	-2.2
Liver weight, right	3.7	6.4	9.3	-2.6	-2.2	-2.9	3.0	3.0	-2.6	-2.7	-2.8	-2.6	-0.3	-1.9
Locomotor activity	0.4	0.6	1.4	1.2	1.1	0.5	-0.5	-0.6	0.7	0.9	0.5	0.9	-0.8	0.1
Locomotor testing distance	0.6	1.5	3.3	1.8	1.8	1.0	-1.0	-1.1	1.2	1.3	0.9	1.3	-1.1	0.1
Locomotor testing rearing	0.1	0.3	1.1	0.6	1.1	-0.0	0.0	0.0	-0.1	-0.1	-0.1	-0.1	-1.0	-0.7
Locomotion in novel chamber	2.8	3.7	6.9	-2.6	-2.3	-2.0	1.9	2.0	-2.0	-1.9	-1.9	-2.2	1.0	-0.8
Locomotion in novel chamber post-restriction	0.2	0.5	0.8	-0.1	-0.2	-0.8	0.8	0.8	-0.7	-0.6	-0.8	-0.5	-0.7	-0.9
Fecal boli incidents, locomotor time 1	0.2	0.6	3.8	0.9	0.8	-0.0	0.2	0.2	-0.2	-0.2	-0.1	-0.2	-2.0	-1.0
Change in fecal boli incidents, locomotor task	0.6	0.6	1.2	0.5	0.1	0.5	-0.5	-0.6	1.0	1.0	0.6	1.1	1.1	0.9
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.8	0.8	0.9	0.2	-0.4	-0.4	0.4	0.4	0.2	0.4	-0.4	-0.4
Bouts of movement, locomotor time 1	0.4	0.5	1.2	0.6	0.2	0.9	-0.8	-0.8	0.7	0.8	0.8	1.1	-0.2	0.6
Total resting periods, locomotor time 1	1.2	1.4	2.3	1.3	0.9	1.4	-1.3	-1.3	1.2	1.3	1.3	1.5	-0.5	0.6
Rest time, locomotor task time 1	0.5	0.8	1.8	1.3	1.1	1.0	-0.8	-0.8	1.0	0.9	1.0	0.8	-0.5	-0.0
Distance moved, locomotor task time 1	0.0	0.1	0.2	-0.2	0.2	0.5	-0.4	-0.4	0.3	0.4	0.5	0.1	0.5	0.4
Vertical activity count, locomotor time 1	0.1	0.9	1.8	-1.4	-1.1	-0.9	0.7	0.7	-0.8	-0.7	-0.7	-1.1	1.3	0.2
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.7	0.6	0.8	0.4	-0.3	-0.3	0.3	0.3	0.4	0.3	-0.6	-0.5
Bouts of movement, locomotor time 2	0.6	1.9	5.3	-2.3	-1.8	-1.3	1.0	1.1	-1.4	-1.4	-1.2	-1.2	1.1	-0.1
Total resting periods, locomotor time 2	0.5	1.9	5.7	-2.4	-2.0	-1.3	1.0	1.1	-1.3	-1.3	-1.1	-1.0	1.4	0.1
Rest time, locomotor task time 2	0.3	0.5	0.8	0.6	0.4	0.8	-0.8	-0.8	0.8	0.7	0.9	0.9	0.2	0.3
Distance moved, locomotor task time 2	0.1	0.2	0.4	0.2	0.3	0.6	-0.4	-0.4	0.4	0.5	0.6	0.1	0.1	0.5
Vertical activity count, locomotor time 2	0.1	0.1	0.5	-0.3	-0.4	-0.3	0.4	0.4	-0.3	-0.2	-0.3	-0.7	0.3	0.3
Light reinforcement 1	0.4	2.0	3.4	1.8	1.5	1.4	-1.4	-1.5	1.8	1.7	1.4	1.5	-0.3	0.5
Light reinforcement 2	0.0	0.1	0.2	0.3	0.0	0.2	-0.1	-0.2	0.5	0.2	0.1	0.3	-0.1	0.2
Bone: marrow area	4.7	11.4	14.5	-3.7	-3.3	-3.8	3.8	3.8	-3.7	-3.7	-3.8	-3.5	0.4	-1.9
Bone: maximum diameter	1.2	2.5	3.6	-1.7	-1.5	-1.8	1.8	1.8	-1.5	-1.5	-1.9	-1.6	0.7	-0.9
Bone: maximum force	6.8	13.5	22.2	-4.5	-4.7	-3.9	3.9	3.9	-3.8	-3.8	-3.9	-3.6	0.9	-1.5
Bone: maximum moment	8.3	15.8	23.3	-4.8	-4.8	-4.2	4.2	4.2	-4.2	-4.2	-4.2	-4.0	0.7	-1.9
Mean time between licks in bursts	0.2	1.3	2.0	1.4	1.3	1.2	-1.1	-1.1	1.2	1.2	1.1	1.1	-1.0	0.1
Mean num. licks in bursts	1.4	3.9	5.2	-1.9	-1.6	-2.1	2.1	2.1	-2.3	-2.2	-2.2	-2.2	-1.0	-1.5
Cd content in liver	0.1	0.2	0.5	0.7	0.7	0.3	-0.3	-0.3	0.3	0.3	0.2	0.1	-0.2	-0.3
Co content in liver	0.0	0.1	0.3	-0.1	-0.1	-0.0	0.1	0.0	0.1	0.1	0.1	0.1	0.6	0.5
Cu content in liver	1.2	1.4	2.1	-1.1	-0.5	-1.4	1.4	1.4	-1.3	-1.3	-1.4	-1.2	-0.1	-0.8
Fe content in liver	0.7	0.9	3.7	1.1	1.9	0.8	-0.8	-0.8	0.9	0.8	0.8	0.6	-0.5	-0.5
K content in liver	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	0.1	0.0	-0.0	-0.1	0.0	-0.0	0.2
Mg content in liver	0.1	0.1	0.3	0.5	0.2	0.0	-0.0	-0.1	0.3	0.2	0.0	0.3	-0.4	0.1
Mn content in liver	0.3	0.4	1.0	0.3	-0.4	0.6	-0.6	-0.6	0.5	0.5	0.6	0.7	0.6	1.0
Na content in liver	0.7	0.8	1.2	-1.1	-0.6	-0.9	0.9	0.9	-1.0	-1.1	-1.0	-1.0	-0.5	-0.6
Rb content in liver	0.2	0.2	1.0	0.7	1.0	0.0	0.0	-0.0	0.2	0.2	0.0	-0.0	-0.6	-0.6
Se content in liver	1.3	1.5	3.4	1.7	1.8	1.2	-1.2	-1.2	1.3	1.1	1.2	1.2	-0.9	-0.1
Sr content in liver	1.3	1.1	1.7	-0.9	-0.7	-1.1	1.1	1.2	-1.3	-1.3	-1.2	-1.2	-0.4	-0.8
Zn content in liver	0.3	0.3	1.3	0.9	1.1	0.2	-0.2	-0.2	0.2	0.3	0.2	0.2	-1.0	-0.5
Bone: minimum diameter	4.0	7.8	12.2	-3.5	-3.2	-3.0	2.9	2.9	-2.9	-2.9	-3.0	-2.8	1.1	-1.2
Time in familiar zone, hab. session 1	0.2	0.2	0.4	0.3	-0.6	0.4	-0.4	-0.4	0.5	0.5	0.4	0.3	-0.0	0.7
Time in novel zone, hab. session 1	0.1	0.1	0.5	-0.2	0.5	0.3	-0.2	-0.2	0.2	0.2	0.3	0.2	0.7	-0.0
Total zone transitions, hab. session 1	2.1	2.9	5.7	0.9	0.3	2.0	-1.8	-1.8	1.7	1.8	1.9	1.8	1.5	2.4
Total locomotion distance, hab. session 1	1.0	1.4	1.9	1.2	0.8	1.4	-1.2	-1.3	1.3	1.3	1.3	1.4	-0.1	1.2
Locomotion velocity, hab. session 1	0.7	1.0	1.4	1.0	0.6	1.2	-1.1	-1.1	1.1	1.1	1.1	1.2	-0.1	1.0
Time in familiar zone, hab. session 2	1.2	1.3	3.1	-1.1	-1.8	-1.2	1.2	1.2	-1.2	-1.3	-1.1	-1.2	-0.3	-0.4
Time in novel zone, hab. session 2	1.6	1.7	3.1	1.2	1.8	1.5	-1.4	-1.4	1.4	1.4	1.4	1.3	0.7	0.6
Total zone transitions, hab. session 2	0.5	0.7	1.2	1.1	0.8	1.0	-0.9	-0.9	0.8	0.8	0.8	0.9	-0.3	0.6
Total locomotion distance, hab. session 2	0.8	1.0	1.9	1.4	1.2	1.1	-1.0	-1.0	1.0	1.0	0.9	1.1	-0.4	0.5
Locomotion velocity, hab. session 2	0.4	0.6	1.4	1.2	1.1	0.8	-0.7	-0.7	0.6	0.6	0.5	0.8	-0.6	0.2
Novel to familiar place preference ratio	0.4	0.6	2.5	-1.3	-1.2	-0.0	0.0	0.1	-0.4	-0.2	-0.0	-0.2	1.6	0.6
Novelty place preference	0.3	0.4	2.0	-1.0	-1.0	0.2	-0.2	-0.1	-0.2	0.0	0.2	-0.1	1.4	0.6
Time in novel zone, NPP test	0.4	0.4	2.3	-0.8	-0.8	0.4	-0.4	-0.4	0.1	0.2	0.4	0.1	1.5	0.8
Total zone transitions, NPP test	3.1	4.6	7.6	2.8	2.2	2.3	-2.2	-2.2	2.3	2.2	2.1	2.4	-0.5	1.5
Total locomotion distance, NPP test	3.7	5.2	10.2	3.2	2.7	2.3	-2.3	-2.3	2.4	2.2	2.1	2.4	-1.3	0.9
Locomotion velocity, NPP test	2.5	3.6	7.8	2.8	2.3	1.9	-1.8	-1.9	2.0	1.8	1.7	2.0	-1.4	0.6
Intraocular pressure	1.4	2.2	5.8	2.1	2.4	1.4	-1.5	-1.4	1.1	1.3	1.3	1.1	-1.4	-0.2
Delta distance traveled before/after self-admin	3.0	3.2	5.5	-0.3	-0.3	-1.9	2.0	1.9	-1.8	-1.8	-1.8	-2.0	-2.3	-2.3
Delta ambulatory time before/after self-admin	1.5	2.6	5.0	-0.1	-0.1	-1.6	1.7	1.7	-1.6	-1.6	-1.7	-1.7	-2.2	-2.1
Parametrial fat weight	0.3	0.7	3.7	1.4	1.1	0.4	-0.3	-0.3	0.5	0.5	0.2	0.5	-1.9	-0.3
Pavlov. Cond. lever latency	0.3	0.3	1.2	0.8	1.1	0.2	-0.1	-0.1	0.1	0.0	0.2	-0.0	-1.0	-0.8
Pavlov. Cond. magazine entry latency	0.7	0.9	2.8	-1.7	-1.6	-0.5	0.5	0.5	-0.7	-0.6	-0.5	-0.6	1.5	0.3
Pavlov. Cond. change in total contacts	0.9	1.0	3.4	-1.6	-1.8	-0.3	0.4	0.4	-0.6	-0.4	-0.3	-0.3	1.7	1.0
Pavlov. Cond. index score	0.9	1.1	3.4	-1.7	-1.8	-0.4	0.4	0.4	-0.5	-0.4	-0.4	-0.4	1.8	0.9
Pavlov. Cond. latency score	0.8	1.0	3.3	-1.7	-1.8	-0.4	0.4	0.4	-0.6	-0.5	-0.4	-0.4	1.7	0.9
Pavlov. Cond. lever contacts	0.3	0.4	1.2	-0.9	-1.1	-0.3	0.3	0.3	-0.3	-0.2	-0.3	-0.1	1.0	0.7
Pavlov. Cond. magazine entry number	0.5	0.7	2.2	1.5	1.3	0.5	-0.5	-0.5	0.6	0.5	0.5	0.6	-1.2	-0.2
Pavlov. Cond. intertrial magazine entries	2.6	3.2	7.2	2.7	2.3	1.7	-1.7	-1.7	1.8	1.7	1.6	1.6	-1.5	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	3.7	-1.7	-1.9	-0.4	0.4	0.4	-0.6	-0.4	-0.4	-0.4	1.7	0.9
Pavlov. Cond. response bias	0.2	0.3	0.9	-0.9	-1.0	-0.3	0.4	0.3	-0.4	-0.3	-0.4	-0.3	0.8	0.2
Pavlov. Cond. lever latency	0.5	0.8	2.7	-1.2	-1.6	-0.3	0.2	0.2	-0.5	-0.5	-0.3	-0.5	1.5	1.0
Pavlov. Cond. magazine entry latency	0.5	0.7	2.6	1.4	1.3	0.2	-0.3	-0.3	0.5	0.5	0.2	0.4	-1.6	-0.7
Pavlov. Cond. change in total contacts	0.1	0.2	0.9	-0.8	-0.8	0.0	0.1	0.0	-0.0	-0.0	0.1	0.0	0.9	0.5
Pavlov. Cond. index score	0.3	0.5	1.7	1.0	1.3	0.3	-0.2	-0.3	0.4	0.5	0.3	0.4	-1.3	-0.8
Pavlov. Cond. latency score	0.3	0.6	1.7	1.0	1.3	0.4	-0.3	-0.4	0.5	0.5	0.3	0.5	-1.3	-0.7
Pavlov. Cond. lever contacts	0.5	0.7	2.5	1.1	1.6	0.2	-0.1	-0.1	0.3	0.4	0.2	0.3	-1.5	-1.1
Pavlov. Cond. magazine entry number	0.2	0.2	1.1	-0.7	-0.5	0.1	-0.0	0.0	-0.2	-0.2	0.2	-0.1	1.1	0.5
Pavlov. Cond. intertrial magazine entries	0.4	0.9	2.1	-0.1	0.7	-0.8	0.7	0.8	-1.0	-1.0	-0.8	-0.9	-1.3	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.4	1.2	0.8	1.1	0.3	-0.2	-0.3	0.4	0.4	0.2	0.4	-1.1	-0.6
Pavlov. Cond. response bias	0.5	0.6	3.0	1.0	1.3	0.0	0.0	-0.0	0.2	0.3	-0.0	0.2	-1.7	-1.1
Time in closed arm before self-admin	0.4	0.8	3.7	-1.1	-1.2	0.2	-0.2	-0.2	0.1	0.1	0.2	0.0	1.9	1.4
Time in closed arm after self-admin	0.6	0.7	3.1	-0.2	-0.7	0.7	-0.7	-0.6	0.5	0.5	0.5	0.7	1.8	1.3
Time in open arm before self-admin	1.4	1.6	3.4	0.7	0.7	1.4	-1.3	-1.3	1.4	1.4	1.4	1.8	0.7	1.4
Time in open arm after self-admin	0.2	0.2	0.4	0.5	0.6	0.3	-0.3	-0.4	0.4	0.4	0.4	0.3	-0.6	0.1
Bone: periosteal estimation	6.4	15.3	20.6	-4.5	-4.0	-4.3	4.4	4.3	-4.1	-4.2	-4.3	-4.0	0.9	-2.2
Bone: periosteal perimeter	4.9	9.7	14.6	-3.8	-3.5	-3.5	3.5	3.4	-3.1	-3.1	-3.5	-3.0	1.6	-1.2
Bone: post-yield work	3.3	5.8	7.3	-2.7	-2.6	-2.5	2.6	2.6	-2.6	-2.6	-2.6	-2.5	0.1	-1.4
Progressive ratio test 1 active lever presses	1.9	3.3	9.9	2.6	3.1	1.7	-1.7	-1.7	1.3	1.5	1.6	1.7	-1.4	-0.4
Progressive ratio test 1 breakpoint	1.8	3.1	9.6	2.6	3.1	1.5	-1.6	-1.6	1.2	1.4	1.5	1.6	-1.5	-0.6
Progressive ratio test 1 inactive lever presses	0.3	0.7	1.6	1.1	1.0	0.7	-0.7	-0.7	0.8	1.0	0.7	1.3	-0.0	0.5
Progressive ratio test 2 active lever presses	0.3	0.5	2.7	0.8	1.6	0.5	-0.3	-0.3	0.2	0.5	0.4	0.9	-0.4	-0.3
Progressive ratio test 2 breakpoint	0.4	0.5	2.4	0.7	1.6	0.5	-0.3	-0.4	0.2	0.6	0.5	0.9	-0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.1	0.4	1.3	0.7	1.1	-0.3	0.4	0.3	-0.2	-0.1	-0.3	0.3	-1.0	-0.8
Incentive Sensitization - Responses	0.2	0.6	1.2	-1.0	-0.7	-0.8	1.1	1.0	-0.8	-0.4	-0.8	-0.1	0.8	0.2
Incentive Sensitization - Breakpoint	0.2	0.5	0.9	-1.0	-0.6	-0.7	0.9	0.9	-0.7	-0.3	-0.7	-0.1	0.9	0.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.6	0.4	0.2	0.3	-0.3	-0.4	0.6	0.6	0.5	0.8	0.2	0.5
Progressive ratio	0.6	1.8	2.8	1.7	1.5	1.4	-1.4	-1.4	1.4	1.5	1.4	1.4	-0.4	0.6
Food seeking constrained by brief footshock	1.5	1.8	4.0	1.7	2.0	1.4	-1.4	-1.4	1.2	1.3	1.5	1.3	-0.7	0.2
Seeking ratio, punishment vs. effort	0.1	0.2	0.4	-0.6	-0.3	-0.3	0.3	0.3	-0.6	-0.5	-0.3	-0.4	-0.0	-0.2
Retroperitoneal fat weight	0.5	2.1	14.5	1.7	1.4	-0.3	0.2	0.2	-0.2	-0.2	-0.4	-0.3	-3.8	-1.9
Reaction time number correct	1.3	4.7	6.8	-2.0	-1.5	-2.4	2.2	2.3	-2.6	-2.5	-2.4	-2.5	-0.6	-1.9
Reaction time mean minus median	0.3	2.2	4.7	2.1	2.2	1.4	-1.5	-1.5	1.4	1.5	1.5	1.5	-0.7	0.5
Reaction time mean minus median AUC	0.3	2.0	3.2	1.8	1.6	1.5	-1.6	-1.6	1.3	1.4	1.6	1.4	-0.2	0.8
Reaction time num false alarms	1.4	2.4	3.5	1.9	1.6	1.7	-1.6	-1.6	1.8	1.8	1.6	1.7	-0.0	1.0
Reaction time num false alarms AUC	1.6	3.6	5.1	2.1	1.7	2.1	-2.0	-2.1	2.2	2.3	2.0	2.1	0.2	1.3
Reaction time trials correct on left	1.3	4.7	6.8	-2.0	-1.5	-2.4	2.2	2.3	-2.6	-2.5	-2.4	-2.5	-0.6	-1.9
Reaction time trials on left	1.3	4.3	6.4	-1.9	-1.4	-2.3	2.1	2.2	-2.5	-2.4	-2.3	-2.4	-0.6	-1.9
Reaction time mean	0.1	0.1	1.0	0.5	1.0	0.1	-0.1	-0.1	0.1	0.0	0.2	0.1	-0.2	-0.4
Reaction time mean AUC	0.0	0.1	0.5	0.2	0.7	-0.1	0.0	0.1	-0.2	-0.2	-0.0	-0.1	-0.1	-0.4
Median of all reaction times	0.1	0.2	0.5	-0.3	0.3	-0.5	0.5	0.5	-0.5	-0.6	-0.5	-0.5	-0.0	-0.7
Reaction time omissions	2.9	4.7	9.7	2.8	3.1	2.3	-2.3	-2.2	2.1	2.0	2.2	2.1	-0.8	0.7
Reaction time false alarm rate	4.9	6.8	9.5	2.5	1.9	2.9	-2.7	-2.8	3.1	3.1	2.8	2.9	0.7	2.2
Reaction time premature initiation rate	0.8	1.3	3.0	1.6	1.7	1.0	-1.1	-1.1	0.9	0.8	1.0	0.8	-1.3	-0.3
Reaction time premature initiations	0.2	0.6	2.6	0.3	0.8	-0.3	0.1	0.2	-0.7	-0.7	-0.4	-0.7	-1.6	-1.4
Std. dev. reaction times	0.9	2.9	5.0	2.2	2.2	1.7	-1.8	-1.8	1.7	1.7	1.8	1.7	-0.5	0.8
Reaction time trials completed	1.3	4.3	6.4	-1.9	-1.4	-2.3	2.1	2.2	-2.5	-2.4	-2.3	-2.4	-0.6	-1.9
Reaction time trials AUC	1.4	5.0	7.2	-2.2	-1.7	-2.5	2.3	2.4	-2.7	-2.6	-2.5	-2.6	-0.4	-1.8
Run reversals in cocaine runway, females	0.7	0.7	1.4	-0.4	-0.6	-1.0	1.1	1.0	-0.9	-0.9	-1.0	-1.2	-0.2	-0.5
Run reversals in cocaine runway, males	0.9	0.9	2.7	0.2	0.5	1.0	-0.7	-0.7	0.9	0.9	1.0	1.0	1.6	1.3
Latency to leave start box in cocaine runway	0.7	1.0	1.5	0.4	0.2	1.1	-1.2	-1.2	1.2	1.2	1.1	1.0	0.3	1.1
Latency to leave start box in cocaine runway, F	2.3	2.9	4.3	1.5	1.2	1.8	-1.8	-1.9	2.0	2.0	1.8	2.1	0.4	1.5
Latency to leave start box in cocaine runway, M	0.7	0.6	1.8	-1.4	-1.3	-0.6	0.3	0.4	-0.6	-0.6	-0.6	-1.2	0.2	-0.1
Std. dev. time between licks in bursts	0.7	1.4	3.3	1.8	1.7	1.1	-1.0	-1.0	1.1	1.2	1.0	1.1	-1.0	-0.1
Total sessions with >9 infusions	1.4	1.7	4.4	1.6	2.1	1.3	-1.3	-1.2	1.1	1.3	1.3	1.4	-0.6	0.0
Short access day 1 total inactive lever presses	0.5	1.0	2.4	1.2	1.5	0.8	-1.2	-1.2	0.7	0.9	0.8	1.1	-0.6	-0.1
Short access day 10 total inactive lever presses	0.0	0.1	0.2	-0.4	-0.3	-0.4	0.0	0.0	-0.2	-0.2	-0.3	-0.2	0.1	-0.1
Short access day 1 total infusions	0.3	0.5	2.4	0.5	1.6	-0.0	-0.0	0.0	-0.3	-0.1	-0.0	0.1	-1.1	-1.3
Short access day 10 total infusions	0.6	1.0	3.4	1.1	1.8	1.0	-0.9	-0.9	0.8	0.9	1.0	1.0	-0.2	-0.1
Short access total infusions	0.9	1.2	5.8	1.4	2.4	0.6	-0.7	-0.6	0.3	0.5	0.6	0.6	-1.4	-1.1
Short access day 1 locomotion	0.1	0.2	0.9	0.6	0.9	0.3	-0.4	-0.4	0.4	0.4	0.4	0.7	-0.3	-0.2
Short access day 10 total locomotion	0.0	0.2	0.9	0.7	1.0	-0.1	-0.2	-0.1	0.2	0.3	-0.1	0.4	-0.1	-0.4
Short access total locomotion	0.4	0.7	2.4	1.3	1.5	0.4	-0.7	-0.6	0.6	0.7	0.4	0.8	-0.6	-0.4
One hour access (0.3 mA shock)	0.7	0.8	1.3	-1.1	-0.5	-1.0	0.9	0.9	-1.1	-0.9	-0.9	-1.1	0.3	-0.7
Compulsive drug intake	0.1	0.1	0.6	-0.1	-0.4	-0.2	0.1	0.0	0.1	0.3	-0.1	0.0	0.8	0.7
One hour access (shock baseline)	0.4	1.0	1.6	-1.3	-0.6	-1.0	0.9	1.0	-1.3	-1.2	-1.0	-1.0	0.0	-0.9
Social response proportion	0.7	0.8	2.0	-0.5	0.1	-0.8	0.9	0.9	-0.9	-1.0	-0.9	-0.9	-1.4	-1.2
Social responses	1.9	2.4	3.8	1.6	2.0	1.8	-1.7	-1.7	1.8	1.6	1.8	1.6	-0.2	0.5
Social time	1.3	2.0	2.9	-1.2	-0.5	-1.5	1.5	1.5	-1.4	-1.5	-1.5	-1.5	-1.4	-1.7
Soleus weight	0.6	1.9	2.8	-1.3	-1.6	-1.7	1.7	1.6	-1.3	-1.3	-1.5	-1.5	-0.1	-0.8
Bone: stiffness	7.9	14.4	24.7	-4.9	-5.0	-3.9	4.0	4.0	-3.9	-3.8	-3.9	-3.7	1.7	-1.2
Tibialis anterior weight	2.1	7.1	39.3	-3.1	-4.0	0.3	-0.4	-0.4	0.3	0.4	0.5	0.2	6.3	3.4
Time to tail flick, vehicle, before self-admin	0.7	0.8	1.4	1.1	1.2	1.0	-1.0	-0.9	1.0	1.0	0.9	0.9	-0.4	0.1
Time to tail flick, vehicle, after self-admin	0.1	0.2	1.2	-0.8	-0.5	-0.1	0.0	0.0	-0.0	-0.0	-0.2	0.1	1.1	0.1
Time to tail flick, test, before self-admin	0.6	0.7	1.0	0.9	0.5	1.0	-0.8	-0.9	0.9	0.9	0.8	0.5	0.8	1.0
Time to tail flick, test, after self-admin	0.5	0.5	0.9	-0.9	-0.8	-0.6	0.7	0.7	-0.6	-0.6	-0.7	-1.0	0.8	-0.1
Delta time to tail flick, vehicle, before/after SA	0.8	0.9	1.3	-1.1	-0.8	-1.1	1.1	1.1	-1.0	-1.0	-1.0	-0.9	0.3	-0.6
Delta time to tail flick, test, before/after SA	0.4	0.5	1.1	-1.1	-0.7	-0.8	0.7	0.7	-0.8	-0.8	-0.7	-0.7	-0.1	-0.4
Tibia length	5.1	14.2	18.5	-3.9	-3.2	-4.3	4.3	4.2	-4.2	-4.2	-4.3	-4.0	-0.3	-2.7
Ambulatory time before self-admin	0.5	1.7	3.3	1.8	1.7	1.2	-1.5	-1.4	1.2	1.2	1.3	1.3	-0.8	0.0
Ambulatory time after self-admin	0.6	1.0	4.8	1.4	1.3	-0.2	0.2	0.2	-0.3	-0.3	-0.2	-0.3	-2.2	-1.5
Bone: tissue strength	0.5	0.5	1.8	-1.0	-1.3	-0.5	0.4	0.5	-0.6	-0.6	-0.5	-0.6	0.7	0.1
Total heroin consumption	1.0	1.2	1.7	-0.7	-0.8	-1.3	1.2	1.2	-1.2	-1.2	-1.2	-1.1	-0.8	-1.1
Bone: trabecular number	3.3	6.2	8.4	-2.4	-2.5	-2.8	2.8	2.8	-2.8	-2.7	-2.9	-2.6	-0.2	-1.3
Bone: trabecular spacing	1.1	1.6	2.2	1.0	1.1	1.5	-1.4	-1.4	1.4	1.4	1.5	1.4	0.5	0.8
Bone: trabecular thickness	0.2	0.3	1.4	-0.6	-1.0	-0.1	0.1	0.0	-0.1	-0.1	-0.1	-0.0	1.2	0.9
Bone: trabecular tissue density	1.5	2.7	5.2	0.3	-0.4	1.7	-1.6	-1.6	1.7	1.7	1.7	1.8	2.0	2.3
Water consumed over 24 hours	0.8	1.6	2.3	-0.4	-0.4	-1.5	1.3	1.4	-1.4	-1.4	-1.5	-1.3	-1.3	-1.5
Number of responses in last shaping day	0.2	0.3	0.7	0.0	0.2	0.5	-0.8	-0.8	0.4	0.5	0.5	0.4	0.7	0.7