Hub : Genes

Bin2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Bin2 0.06 0.04 1.3e-06 0.06 0.05 0.05 0.05 7.8e-07 2.5e-06 3.7e-06 4.4e-06
2 pVTA intron excision ratio chr7_131773464_131774060 0.13 0.11 1.1e-03 0.03 0.05 0.05 0.05 2.7e-02 2.7e-03 4.5e-03 4.0e-03
3 Liver mRNA stability Bin2 0.07 0.04 1.4e-07 0.06 0.06 0.06 0.05 1.8e-07 8.6e-07 1.8e-07 1.1e-06
4 pVTA intron excision ratio chr7_131760702_131768086 0.14 0.11 1.8e-03 0.03 0.04 0.02 0.03 2.6e-02 9.3e-03 3.7e-02 2.7e-02
5 Liver gene expression Bin2 0.57 0.17 0.0e+00 0.18 0.18 0.16 0.18 1.3e-19 3.5e-19 6.7e-18 8.9e-20
6 NAcc gene expression Bin2 0.16 0.08 4.1e-12 0.12 0.11 0.11 0.12 2.5e-13 1.4e-12 9.9e-13 1.6e-13
7 BLA gene expression Bin2 0.15 0.09 4.6e-04 0.07 0.06 0.06 0.07 1.5e-04 2.4e-04 2.5e-04 2.0e-04
8 Brain gene expression Bin2 0.2 0.09 7.4e-14 0.16 0.16 0.17 0.16 7.6e-15 2.0e-14 2.1e-15 4.2e-15
9 pVTA gene expression Bin2 0.26 0.14 7.2e-07 0.15 0.16 0.17 0.17 3.6e-07 3.0e-07 1.1e-07 8.1e-08
10 Eye gene expression Bin2 0.4 0.18 9.1e-03 0.06 0.05 0 0.03 4.5e-02 6.9e-02 2.8e-01 1.0e-01
11 PL gene expression Bin2 0.12 0.06 7.8e-08 0.08 0.08 0.08 0.08 4.5e-09 5.7e-09 5.2e-09 1.6e-09
12 IL gene expression Bin2 0.28 0.15 2.9e-04 0.15 0.21 0.22 0.2 2.0e-04 1.0e-05 6.5e-06 1.8e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density5.59.213.4-3.33.7-3.3-3.63.63.5-3.4-3.43.21.0-0.5-1.4
Area under the delay curve0.40.41.2-0.80.9-1.1-0.80.70.6-0.6-0.50.40.5-0.2-0.2
BMI with tail2.58.020.9-4.63.6-3.5-3.32.72.4-2.4-2.42.62.0-1.9-0.5
BMI without tail0.91.93.6-1.31.6-0.7-1.61.71.7-1.8-1.71.90.4-0.1-0.5
Body weight3.112.823.1-4.84.6-4.3-4.43.83.5-3.5-3.53.91.3-1.2-1.5
Weight adjusted by age0.60.62.3-0.6-0.2-0.30.4-0.5-0.70.70.6-0.61.5-1.50.8
Bone surface7.613.419.8-4.34.4-4.1-4.44.34.2-4.1-4.13.70.5-0.1-1.9
Bone volume6.611.317.0-3.84.1-3.8-4.03.93.8-3.7-3.73.41.2-0.8-1.5
Breakpoint value in progressive ratio session0.40.40.6-0.30.6-0.2-0.60.70.8-0.7-0.60.6-0.80.5-0.7
Number of licking bursts1.61.93.11.7-1.51.01.5-1.7-1.71.71.8-1.7-0.2-0.00.5
Context. condit. distance diff. score0.91.11.9-0.91.0-0.6-1.11.21.2-1.3-1.21.4-0.41.0-0.9
Locomotion velocity, session 12.93.25.31.8-2.22.22.1-2.0-1.81.81.8-2.3-0.81.00.6
Locomotion distance, session 12.73.45.81.8-2.21.92.2-2.1-2.02.12.1-2.4-0.20.11.2
Locomotion velocity, session 20.30.30.60.6-0.60.60.6-0.5-0.50.50.5-0.8-0.60.50.0
Locomotion distance, session 23.14.36.52.4-2.42.12.4-2.4-2.32.32.3-2.5-0.1-0.01.3
Locomotion velocity, session 32.42.86.42.5-2.02.31.8-1.5-1.31.21.3-1.3-1.51.9-0.1
Locomotion distance, session 31.11.24.11.7-0.91.70.60.10.3-0.4-0.30.2-1.62.0-0.8
Stereotopy head waving bouts, day 31.72.03.80.5-1.00.01.1-1.7-1.91.91.8-2.00.9-1.31.4
Stereotopy head waving duration, day 30.60.81.61.0-0.80.30.8-1.1-1.21.21.2-1.3-0.1-0.00.4
Locomotion velocity, session 71.11.23.61.9-1.21.91.0-0.4-0.10.10.1-0.3-1.71.4-0.3
Locomotion distance, session 71.82.35.52.3-1.62.31.3-0.8-0.60.50.5-0.6-2.32.3-0.7
Stereotopy head waving bouts, day 70.80.93.3-0.80.1-0.70.2-0.6-0.60.80.8-1.11.3-1.81.4
Stereotopy head waving duration, day 70.70.82.8-1.10.4-1.0-0.1-0.4-0.50.70.7-0.81.2-1.71.2
Locomotion velocity, session 80.30.40.80.6-0.80.90.8-0.7-0.70.60.7-0.70.00.10.4
Locomotion distance, session 80.40.61.41.0-1.01.20.9-0.7-0.60.50.5-0.6-0.71.1-0.1
Degree of sensitization distance0.30.30.7-0.1-0.30.00.4-0.7-0.70.80.7-0.80.1-0.30.4
Degree of sensitization stereotypy0.80.83.5-1.30.3-0.8-0.0-0.2-0.30.40.5-0.61.4-1.91.2
Conditioned locomotion0.00.10.30.5-0.00.0-0.10.10.1-0.1-0.10.2-0.30.4-0.2
Cocaine response after cond. corrected0.40.51.30.3-0.50.00.5-0.8-0.90.80.9-1.10.3-0.50.7
Cocaine response after cond. not corrected0.30.30.60.5-0.60.50.6-0.6-0.60.60.6-0.8-0.2-0.10.6
Cocaine response before conditioning0.70.92.81.1-0.71.50.50.00.3-0.3-0.20.3-1.71.6-0.6
Saline control response0.60.71.4-0.10.6-0.0-0.71.01.2-1.1-1.10.9-0.90.8-0.7
Bone: connectivity density3.35.27.3-2.52.6-2.3-2.72.72.7-2.6-2.62.3-0.20.7-1.4
Bone: cortical apparent density1.72.23.30.8-1.30.61.5-1.7-1.81.71.7-1.51.6-1.41.8
Bone: cortical area4.56.810.6-2.93.3-2.9-3.23.02.9-2.9-2.92.81.2-0.4-1.4
Bone: cortical porosity1.21.42.4-0.30.9-0.4-1.01.41.5-1.5-1.51.6-0.91.0-1.2
Bone: cortical porosity0.91.01.90.00.6-0.1-0.81.21.2-1.2-1.31.4-1.01.1-1.1
Bone: cortical thickness1.32.13.3-1.61.8-1.5-1.81.61.6-1.6-1.61.61.0-0.2-0.9
Bone: cortical thickness0.20.20.50.3-0.00.6-0.10.20.4-0.3-0.40.6-0.70.7-0.5
Bone: cortical tissue density1.82.33.31.0-1.40.81.6-1.7-1.81.81.7-1.51.5-1.31.8
Condit. Reinf. active minus inactive responses0.00.00.3-0.3-0.10.20.2-0.1-0.10.10.1-0.1-0.50.10.0
Condit. Reinf. active-inactive response ratio0.70.81.1-0.60.7-0.5-0.81.00.9-1.0-0.91.0-1.10.8-0.9
Condit. Reinf. active responses0.50.71.10.3-1.00.91.0-1.0-1.00.91.0-0.9-0.2-0.10.6
Condit. Reinf. inactive responses3.54.26.01.7-2.31.92.3-2.4-2.42.42.4-2.50.8-0.71.6
Incentive salience index mean0.10.10.6-0.80.1-0.10.1-0.1-0.20.10.20.00.3-0.50.1
Condit. Reinf. lever presses0.40.51.6-1.30.3-0.8-0.1-0.3-0.40.40.4-0.21.1-1.20.5
Condit. Reinf. active minus inactive responses0.50.72.2-1.51.0-1.2-0.80.60.5-0.4-0.50.31.1-0.90.1
Condit. Reinf. active-inactive response ratio0.40.41.4-1.20.9-1.0-0.80.50.4-0.5-0.50.50.4-0.4-0.3
Condit. Reinf. active responses0.20.31.0-0.80.4-0.4-0.30.20.2-0.2-0.2-0.11.0-0.90.5
Condit. Reinf. inactive responses0.40.51.00.5-0.81.00.9-0.6-0.50.50.5-0.80.6-0.51.0
Condit. Reinf. lever presses0.30.30.80.30.30.0-0.50.70.7-0.7-0.70.6-0.20.8-0.9
Condit. Reinf. lever reinforcers received0.00.10.3-0.40.1-0.0-0.00.10.1-0.1-0.1-0.20.5-0.40.2
Conditioned reinforcement - actives1.31.31.91.4-1.21.01.2-1.3-1.21.31.4-1.4-0.3-0.10.9
Conditioned reinforcement - inactives1.11.22.21.5-1.21.51.1-1.2-0.91.21.1-1.0-0.90.70.4
Conditioned locomotion0.20.31.10.7-0.30.30.2-0.4-0.30.40.4-0.4-1.10.8-0.3
Patch foraging indifference point 0 sec1.82.89.02.4-2.23.02.0-1.3-1.01.01.0-1.2-1.31.40.5
Patch foraging indifference point AUC1.01.11.80.3-0.90.41.0-1.2-1.31.21.3-1.40.9-1.01.1
Delay disc. indifference point, 0s delay1.01.12.0-1.21.3-1.4-1.21.21.1-1.1-1.00.90.5-0.3-0.4
Delay disc. indifference point, 16s delay0.50.50.9-0.81.0-1.0-0.90.80.8-0.7-0.70.60.20.1-0.4
Delay disc. indifference point, 2s delay1.51.66.2-1.50.7-1.4-0.30.0-0.30.20.3-0.32.5-2.51.5
Delay disc. indifference point, 24s delay0.20.20.8-0.60.6-0.9-0.50.30.1-0.1-0.10.10.4-0.2-0.1
Delay disc. indifference point, 4s delay0.40.40.9-0.80.9-1.0-0.80.60.5-0.5-0.50.50.6-0.4-0.2
Delay disc. indifference point, 8s delay1.31.42.0-1.01.4-1.2-1.41.41.4-1.4-1.31.2-0.20.6-1.0
Indifference point function ln k3.44.87.4-2.52.7-2.7-2.72.52.4-2.3-2.32.20.10.0-1.5
Indifference point function log k3.44.87.4-2.52.7-2.7-2.72.52.4-2.3-2.32.20.10.0-1.5
Patch foraging total patch changes 0 sec1.62.68.32.4-2.02.91.8-1.1-0.70.80.8-1.0-1.61.70.2
Patch foraging total patch changes 12 sec2.73.57.52.1-2.52.72.4-2.0-1.81.71.8-1.7-0.30.61.1
Patch foraging total patch changes 18 sec3.24.19.12.6-2.73.02.5-2.0-1.71.81.8-1.9-0.80.81.0
Patch foraging total patch changes 24 sec1.62.04.91.9-1.82.21.7-1.4-1.21.31.2-1.2-0.80.80.6
Patch foraging total patch changes 6 sec3.14.69.92.7-2.83.12.7-2.2-1.91.92.0-2.1-1.11.00.9
Patch foraging time to switch 0 sec1.21.94.01.6-1.82.01.8-1.4-1.31.31.3-1.0-0.0-0.41.2
Patch foraging water rate 0 sec2.13.45.9-2.12.4-2.3-2.42.01.9-1.8-1.91.7-0.10.5-1.5
Patch foraging water rate 12 sec2.03.14.5-1.72.1-2.1-2.12.01.9-1.9-1.91.8-0.30.5-1.6
Patch foraging water rate 18 sec0.20.20.8-0.40.6-0.9-0.60.50.3-0.4-0.40.5-0.10.4-0.4
Patch foraging water rate 24 sec2.12.96.0-2.12.2-2.5-2.11.71.6-1.5-1.61.60.8-0.3-1.0
Patch foraging water rate 6 sec3.85.68.8-2.73.0-2.9-2.92.72.5-2.5-2.52.20.50.2-1.7
Seeking ratio, delayed vs. immediate footshock0.50.51.4-1.20.8-1.0-0.70.80.7-0.8-0.70.60.7-0.4-0.0
Distance traveled before self-admin1.21.33.01.4-1.51.71.5-1.2-1.01.01.0-1.0-0.60.40.4
Distance traveled after self-admin0.50.52.30.7-0.60.90.4-0.10.1-0.10.00.0-1.51.2-0.6
Extensor digitorum longus weight2.39.225.0-5.03.2-4.1-2.51.50.9-1.0-0.90.84.6-4.61.9
Bone: elastic displacement4.14.79.83.1-2.62.92.3-1.9-1.71.61.6-1.4-2.62.4-0.1
Bone: elastic work0.50.62.60.7-0.10.2-0.10.30.3-0.3-0.30.4-1.41.6-1.3
Bone: endosteal estimation5.612.118.7-3.74.3-4.0-4.34.13.9-3.9-3.83.60.3-0.3-1.9
Bone: endosteal perimeter4.59.415.6-3.44.0-3.7-3.83.53.3-3.3-3.22.91.2-0.8-1.5
Epididymis fat weight1.63.88.3-0.31.20.0-1.51.82.1-1.9-2.12.4-2.92.5-2.3
Delta time in closed arm before/after self-admin0.20.20.3-0.40.5-0.5-0.50.50.6-0.5-0.60.5-0.10.1-0.3
Delta time in open arm before/after self-admin1.61.54.31.8-1.21.90.9-0.5-0.30.30.20.0-1.92.1-0.8
Diff in mean of infusions in LGA sessions1.21.33.1-1.81.3-1.3-1.11.11.0-1.0-1.00.91.2-1.4-0.1
Delay discount exponential model param0.40.41.10.8-0.81.00.8-0.6-0.40.50.4-0.3-0.60.30.1
Extinction: sum of active levers before priming0.80.82.5-1.61.0-0.9-0.80.90.8-0.8-0.70.81.0-1.0-0.1
Active lever presses in extinction session 60.10.10.6-0.10.3-0.2-0.30.30.3-0.2-0.20.2-0.80.3-0.2
Bone: final force8.814.320.8-4.14.6-4.1-4.54.44.2-4.3-4.24.00.40.1-2.4
Bone: final moment10.316.724.2-4.34.9-4.4-4.94.84.6-4.6-4.64.50.10.3-2.6
Food consumed during 24 hour testing period2.93.54.5-1.81.9-1.6-2.02.12.1-2.1-2.12.1-0.91.4-1.9
Glucose0.00.10.4-0.0-0.20.60.2-0.00.0-0.1-0.0-0.20.4-0.30.2
Heart weight0.40.61.6-0.60.7-0.4-0.80.91.0-0.9-1.01.3-0.00.3-0.4
Delay discount hyperbolic model param0.40.41.20.9-0.81.10.7-0.5-0.40.40.3-0.2-0.80.6-0.1
Intermittent access intake day 1-15 change0.60.61.90.50.00.4-0.20.60.6-0.7-0.80.7-1.41.3-0.8
Intermittent access intake escalation1.11.12.80.20.40.0-0.60.91.0-1.1-1.11.1-1.61.7-1.1
Intermittent access intake escalation 20.70.71.30.20.30.2-0.40.80.9-1.0-1.11.1-1.11.0-0.9
Intermitt. access day 1 inactive lever presses0.20.20.80.6-0.30.50.2-0.3-0.10.20.2-0.3-0.90.5-0.3
Intermitt. access day 15 inactive lever presses0.20.31.10.9-0.20.20.1-0.1-0.00.10.00.1-0.91.0-0.6
Intermitt. access escalation Index2.11.82.90.7-1.40.81.6-1.5-1.71.61.6-1.51.1-1.11.3
Intermittent access day 1 total infusions0.80.92.21.5-1.11.21.0-0.9-0.80.90.9-0.8-1.20.40.5
Intermittent access day 15 total infusions1.01.13.91.7-1.01.40.8-0.5-0.40.30.3-0.2-2.01.4-0.1
Intermittent access terminal intake (last 3 days)0.91.02.81.6-1.11.30.9-0.6-0.60.40.5-0.4-1.70.90.3
Intermittent access total infusions0.91.03.21.6-1.01.30.9-0.6-0.60.40.5-0.5-1.81.00.2
Intermittent access day 1 locomotion1.01.02.61.6-1.01.20.8-0.7-0.60.70.6-0.4-1.61.4-0.1
Intermittent access day 15 total locomotion0.90.93.81.4-0.41.10.20.00.2-0.2-0.30.3-2.01.7-1.0
Intermittent access total locomotion2.02.35.92.4-1.62.11.4-1.3-1.01.11.0-1.0-2.11.70.0
Intermittent access standard deviation1.21.32.70.30.5-0.1-0.71.11.1-1.3-1.31.4-1.61.3-1.4
Left kidney weight1.23.34.9-2.22.1-1.6-2.12.22.1-2.1-2.12.20.3-0.1-0.7
Right kidney weight1.74.79.9-3.12.5-2.3-2.42.42.3-2.2-2.22.21.3-1.1-0.5
Cocaine induced anxiety1.61.93.3-1.21.4-0.9-1.51.61.7-1.7-1.71.8-0.70.5-0.9
Post-drug Anxiety4.34.86.9-2.42.6-2.3-2.62.52.4-2.4-2.52.60.2-0.2-1.2
Baseline Anxiety0.30.30.8-0.60.7-0.9-0.60.40.4-0.4-0.40.20.7-0.3-0.5
Tail length0.41.22.10.60.90.1-1.11.21.4-1.4-1.41.5-1.01.0-0.8
Length with tail1.34.77.7-1.92.8-2.4-2.82.52.4-2.4-2.42.50.20.0-1.4
Length without tail2.14.59.3-3.02.7-3.1-2.62.11.9-1.8-1.91.81.1-1.0-1.0
Times rat made contact with spout0.30.41.0-0.40.40.1-0.40.60.7-0.7-0.70.6-0.30.8-1.0
Lifetime Intake1.31.55.02.0-1.21.61.0-0.6-0.60.50.5-0.5-2.21.5-0.1
Liver weight, left1.82.94.3-1.42.0-1.7-2.12.02.0-1.9-2.02.0-0.30.5-1.4
Liver weight, right2.13.54.9-1.82.1-1.6-2.22.12.2-2.1-2.22.2-0.90.9-1.6
Locomotor activity0.60.91.91.1-1.11.21.0-1.0-0.91.01.0-1.40.00.40.2
Locomotor testing distance1.22.04.41.9-1.82.11.6-1.4-1.21.31.3-1.6-0.40.90.2
Locomotor testing rearing0.30.53.11.0-0.91.80.8-0.20.1-0.0-0.1-0.1-0.20.8-0.1
Locomotion in novel chamber1.51.83.3-1.71.7-1.8-1.61.21.1-1.0-1.11.41.2-1.3-0.1
Locomotion in novel chamber post-restriction0.81.01.3-0.51.0-0.8-1.11.11.1-1.1-1.11.1-0.81.0-1.1
Fecal boli incidents, locomotor time 10.91.04.60.9-0.51.00.2-0.00.2-0.1-0.0-0.0-2.11.9-1.2
Change in fecal boli incidents, locomotor task0.60.51.5-0.2-0.1-0.50.2-0.6-0.80.70.7-0.61.0-1.21.1
Time >=10cm from walls, locomotor time 10.20.20.70.7-0.40.40.3-0.4-0.30.30.3-0.3-0.80.8-0.0
Bouts of movement, locomotor time 10.20.30.60.0-0.3-0.20.4-0.6-0.60.80.6-0.60.6-0.30.2
Total resting periods, locomotor time 10.80.81.60.8-1.00.41.0-1.2-1.21.31.2-1.10.10.00.4
Rest time, locomotor task time 10.60.71.10.9-0.90.70.9-1.0-0.91.01.0-1.0-0.3-0.00.4
Distance moved, locomotor task time 10.10.10.20.2-0.20.30.3-0.3-0.30.30.3-0.30.3-0.30.4
Vertical activity count, locomotor time 10.60.61.2-1.10.9-0.8-0.80.80.7-0.7-0.80.90.7-0.60.1
Time >=10cm from walls, locomotor time 20.20.20.60.8-0.50.50.4-0.2-0.20.20.1-0.1-0.70.8-0.1
Bouts of movement, locomotor time 21.81.93.6-1.81.8-1.9-1.71.51.4-1.3-1.31.20.5-0.4-0.2
Total resting periods, locomotor time 21.82.04.0-2.01.9-2.0-1.71.41.3-1.2-1.21.10.9-0.80.0
Rest time, locomotor task time 20.20.30.50.3-0.50.30.5-0.6-0.70.70.7-0.6-0.0-0.50.6
Distance moved, locomotor task time 20.10.10.30.3-0.50.40.5-0.4-0.40.40.3-0.40.50.00.2
Vertical activity count, locomotor time 20.10.10.3-0.40.2-0.3-0.20.30.3-0.2-0.30.30.60.1-0.3
Light reinforcement 11.12.03.51.6-1.51.01.5-1.7-1.81.71.8-1.90.7-0.10.5
Light reinforcement 20.20.21.30.1-0.1-0.10.2-0.3-0.40.30.4-0.41.1-0.60.1
Bone: marrow area5.411.617.8-3.64.2-3.9-4.24.03.8-3.8-3.83.60.3-0.2-1.9
Bone: maximum diameter1.32.43.9-1.72.0-1.6-1.91.71.6-1.6-1.61.61.1-0.5-0.5
Bone: maximum force8.915.423.9-4.64.9-4.9-4.84.44.1-4.1-4.14.01.2-0.6-2.1
Bone: maximum moment10.518.127.8-4.85.3-5.2-5.24.94.6-4.6-4.64.50.8-0.4-2.4
Mean time between licks in bursts0.60.81.41.1-0.90.20.8-1.1-1.21.21.1-0.9-0.60.4-0.0
Mean num. licks in bursts2.22.74.8-1.51.5-0.6-1.62.02.2-2.1-2.22.0-0.20.9-1.2
Cd content in liver0.30.40.90.8-0.60.70.5-0.5-0.50.40.4-0.3-0.90.8-0.1
Co content in liver0.10.10.6-0.2-0.10.80.10.30.4-0.4-0.30.2-0.50.2-0.3
Cu content in liver0.91.02.4-0.91.0-0.5-1.01.21.3-1.3-1.31.5-0.0-0.0-0.3
Fe content in liver0.60.72.31.5-1.01.21.0-0.9-0.80.80.8-0.7-0.3-0.10.2
K content in liver0.00.00.1-0.2-0.20.30.2-0.1-0.10.10.10.10.00.0-0.1
Mg content in liver0.20.20.40.1-0.60.40.6-0.6-0.60.60.6-0.60.00.10.1
Mn content in liver0.10.20.7-0.90.3-0.4-0.20.20.1-0.1-0.0-0.10.6-0.70.3
Na content in liver0.10.10.4-0.1-0.20.60.30.10.2-0.2-0.20.40.6-0.40.1
Rb content in liver0.50.72.61.2-1.11.60.9-0.5-0.30.40.3-0.4-0.80.70.1
Se content in liver1.31.52.81.2-1.51.71.5-1.4-1.41.31.3-1.2-0.70.20.6
Sr content in liver0.80.71.30.00.5-0.1-0.71.01.1-1.1-1.21.1-0.70.8-1.0
Zn content in liver1.31.52.71.6-1.51.61.3-1.2-1.11.11.0-0.9-1.11.20.1
Bone: minimum diameter4.88.915.2-3.33.9-3.9-3.83.43.1-3.1-3.02.71.1-0.6-1.5
Time in familiar zone, hab. session 10.10.10.3-0.3-0.2-0.10.2-0.5-0.50.50.4-0.40.6-0.00.2
Time in novel zone, hab. session 10.00.00.20.30.0-0.20.0-0.0-0.10.00.2-0.30.1-0.40.3
Total zone transitions, hab. session 11.92.74.50.2-1.10.21.4-1.7-1.81.91.9-2.12.1-2.01.7
Total locomotion distance, hab. session 11.01.42.70.7-1.20.61.2-1.4-1.41.51.4-1.70.8-0.60.9
Locomotion velocity, hab. session 10.71.01.90.5-1.00.51.0-1.2-1.21.31.2-1.40.8-0.60.7
Time in familiar zone, hab. session 21.41.52.6-1.61.3-1.3-1.31.31.2-1.3-1.21.4-0.20.6-1.1
Time in novel zone, hab. session 21.71.72.71.6-1.41.31.4-1.4-1.31.31.4-1.60.3-0.61.3
Total zone transitions, hab. session 20.50.61.30.8-0.80.50.9-0.9-0.90.90.9-1.10.4-0.30.4
Total locomotion distance, hab. session 20.60.81.31.1-1.00.70.9-1.0-1.01.11.0-1.1-0.10.20.5
Locomotion velocity, hab. session 20.30.40.91.0-0.70.50.6-0.7-0.70.70.7-0.90.00.20.2
Novel to familiar place preference ratio0.91.03.7-1.30.9-1.2-0.60.40.2-0.2-0.2-0.11.7-1.90.6
Novelty place preference0.70.73.2-1.00.6-1.0-0.40.20.0-0.10.0-0.31.6-1.80.6
Time in novel zone, NPP test0.70.73.4-0.90.4-0.8-0.2-0.0-0.20.20.2-0.51.6-1.80.8
Total zone transitions, NPP test3.04.26.62.1-2.41.92.4-2.4-2.32.42.3-2.60.5-0.31.3
Total locomotion distance, NPP test3.44.77.02.6-2.62.22.5-2.5-2.42.42.4-2.6-0.30.60.9
Locomotion velocity, NPP test2.23.25.02.2-2.11.82.0-2.0-1.92.01.9-2.1-0.40.70.6
Intraocular pressure1.72.46.52.2-2.02.61.8-1.3-1.01.00.9-0.7-1.41.80.1
Delta distance traveled before/after self-admin1.82.02.8-0.61.1-0.4-1.31.51.5-1.6-1.61.6-1.61.7-1.7
Delta ambulatory time before/after self-admin1.61.83.3-0.30.9-0.3-1.11.41.4-1.5-1.41.5-1.81.7-1.6
Parametrial fat weight0.91.87.41.3-0.81.50.5-0.4-0.20.20.2-0.3-2.72.7-1.3
Pavlov. Cond. lever latency0.30.42.01.1-0.30.50.1-0.00.0-0.1-0.1-0.0-1.11.4-0.5
Pavlov. Cond. magazine entry latency0.60.72.4-1.40.9-1.3-0.70.40.3-0.2-0.20.30.9-1.50.5
Pavlov. Cond. change in total contacts0.91.03.3-1.80.9-1.2-0.70.40.3-0.3-0.20.31.3-1.80.5
Pavlov. Cond. index score0.81.04.1-1.70.8-1.0-0.60.40.3-0.2-0.20.31.3-2.00.6
Pavlov. Cond. latency score0.70.93.8-1.70.8-0.9-0.50.40.4-0.3-0.20.21.4-2.00.6
Pavlov. Cond. lever contacts0.20.31.4-1.00.4-0.3-0.20.20.2-0.1-0.10.20.7-1.20.3
Pavlov. Cond. magazine entry number0.30.41.21.1-0.70.80.6-0.5-0.50.40.4-0.6-0.20.7-0.0
Pavlov. Cond. intertrial magazine entries2.53.06.42.2-2.42.52.2-1.9-1.61.71.5-1.3-0.71.00.6
Pavlov. Cond. lever-magazine prob. diff.0.81.03.7-1.81.0-1.2-0.70.50.4-0.3-0.30.31.2-1.90.5
Pavlov. Cond. response bias0.20.20.8-0.90.5-0.7-0.40.20.2-0.1-0.10.40.2-0.90.1
Pavlov. Cond. lever latency0.50.62.4-1.50.9-1.2-0.80.60.5-0.5-0.50.50.3-1.00.4
Pavlov. Cond. magazine entry latency0.60.72.51.2-0.40.40.2-0.4-0.40.40.4-0.4-1.31.6-1.0
Pavlov. Cond. change in total contacts0.50.63.8-0.80.5-0.8-0.3-0.0-0.20.20.2-0.42.0-1.40.3
Pavlov. Cond. index score0.40.51.91.4-0.70.80.6-0.6-0.60.60.5-0.6-0.50.8-0.6
Pavlov. Cond. latency score0.40.51.71.3-0.70.70.5-0.6-0.50.50.5-0.6-0.40.8-0.6
Pavlov. Cond. lever contacts0.50.62.71.6-0.81.10.6-0.5-0.40.40.3-0.3-0.61.2-0.7
Pavlov. Cond. magazine entry number0.10.20.6-0.60.1-0.1-0.00.30.2-0.3-0.20.20.4-0.70.7
Pavlov. Cond. intertrial magazine entries0.81.12.90.5-0.31.50.00.81.1-1.1-1.11.0-1.71.5-0.6
Pavlov. Cond. lever-magazine prob. diff.0.20.31.01.0-0.50.50.4-0.5-0.40.50.4-0.5-0.10.5-0.5
Pavlov. Cond. response bias0.40.61.91.4-0.60.80.4-0.4-0.30.30.3-0.2-0.71.3-1.0
Time in closed arm before self-admin0.40.41.4-1.00.6-0.8-0.40.20.1-0.1-0.10.11.1-1.20.5
Time in closed arm after self-admin0.50.51.9-0.70.3-0.7-0.1-0.2-0.30.30.3-0.41.4-1.30.9
Time in open arm before self-admin1.11.22.6-0.2-0.5-0.40.7-0.9-1.11.11.2-1.41.4-1.61.5
Time in open arm after self-admin0.30.30.50.6-0.70.50.7-0.7-0.70.60.6-0.6-0.20.10.3
Bone: periosteal estimation7.214.923.1-4.14.8-4.4-4.74.54.3-4.3-4.34.11.0-0.5-2.1
Bone: periosteal perimeter5.79.616.3-3.74.0-3.9-3.93.43.1-3.1-3.13.01.6-1.0-1.1
Bone: post-yield work5.77.811.5-3.13.4-3.4-3.33.23.1-3.0-3.03.10.6-0.4-1.4
Progressive ratio test 1 active lever presses4.04.110.13.2-2.53.02.2-1.6-1.61.31.5-1.4-2.31.90.3
Progressive ratio test 1 breakpoint3.43.68.73.0-2.32.72.1-1.5-1.51.31.4-1.4-2.11.60.4
Progressive ratio test 1 inactive lever presses1.31.42.91.7-1.41.61.2-1.3-1.01.21.1-1.1-1.00.90.3
Progressive ratio test 2 active lever presses0.80.92.51.6-1.01.40.8-0.3-0.30.20.4-0.4-1.61.30.1
Progressive ratio test 2 breakpoint0.80.92.41.6-1.01.50.8-0.4-0.30.20.4-0.4-1.51.20.1
Progressive ratio test 2 inactive lever presses0.70.83.31.4-0.71.10.5-0.3-0.10.10.2-0.1-1.81.5-0.4
Incentive Sensitization - Responses0.40.40.7-0.70.8-0.5-0.80.70.8-0.7-0.60.60.6-0.50.0
Incentive Sensitization - Breakpoint0.30.30.5-0.70.7-0.5-0.60.60.7-0.5-0.50.50.7-0.60.2
Sum of active levers in priming session hrs 5-60.60.61.00.8-0.90.60.9-0.8-0.90.81.0-1.0-0.30.10.5
Progressive ratio0.91.11.51.2-1.21.01.2-1.2-1.21.11.1-1.2-0.50.50.4
Food seeking constrained by brief footshock0.91.12.31.5-1.51.51.4-1.0-0.80.90.9-0.7-0.90.50.7
Seeking ratio, punishment vs. effort0.20.30.6-0.50.5-0.3-0.50.70.8-0.7-0.60.70.0-0.1-0.2
Retroperitoneal fat weight0.51.65.41.7-1.21.90.9-0.6-0.40.40.3-0.0-2.02.3-0.9
Reaction time number correct2.84.06.9-1.62.0-1.3-2.12.62.6-2.6-2.62.5-0.80.5-1.3
Reaction time mean minus median2.02.66.92.1-2.22.62.1-1.5-1.31.31.3-1.40.00.41.1
Reaction time mean minus median AUC1.72.34.91.5-2.02.22.0-1.5-1.31.41.3-1.50.7-0.21.2
Reaction time num false alarms2.02.75.41.6-1.81.31.8-2.0-1.92.02.0-2.3-0.40.30.8
Reaction time num false alarms AUC2.63.67.31.6-2.01.32.1-2.3-2.32.42.4-2.7-0.10.01.1
Reaction time trials correct on left2.84.06.9-1.62.0-1.3-2.12.62.6-2.6-2.62.5-0.80.5-1.3
Reaction time trials on left2.63.76.5-1.51.9-1.1-2.02.52.5-2.5-2.52.4-0.80.5-1.3
Reaction time mean0.20.21.11.0-0.51.00.4-0.2-0.10.10.00.2-0.50.40.1
Reaction time mean AUC0.10.10.60.7-0.30.70.20.00.1-0.1-0.20.4-0.40.4-0.1
Median of all reaction times0.10.20.50.40.20.1-0.30.30.4-0.4-0.50.7-0.70.4-0.3
Reaction time omissions3.24.310.53.1-2.83.22.6-2.0-1.61.71.7-1.8-0.91.00.8
Reaction time false alarm rate4.76.512.52.0-2.51.52.6-3.2-3.23.33.3-3.50.6-0.61.7
Reaction time premature initiation rate1.72.25.92.0-2.02.41.8-1.1-0.90.81.0-0.7-1.41.80.2
Reaction time premature initiations0.81.23.91.0-0.81.60.50.40.7-0.7-0.60.7-1.82.0-0.6
Std. dev. reaction times2.13.06.42.2-2.32.52.2-1.8-1.61.61.6-1.50.00.21.3
Reaction time trials completed2.63.76.5-1.51.9-1.1-2.02.52.5-2.5-2.52.4-0.80.5-1.3
Reaction time trials AUC3.04.37.2-1.82.2-1.4-2.22.62.7-2.7-2.72.5-0.60.3-1.3
Run reversals in cocaine runway, females0.80.81.2-0.60.9-0.7-1.01.01.0-1.1-1.01.1-0.80.7-0.7
Run reversals in cocaine runway, males1.41.43.50.5-1.10.81.2-1.1-1.01.11.2-1.21.1-1.41.9
Latency to leave start box in cocaine runway1.21.32.40.4-0.8-0.21.0-1.3-1.51.41.4-1.41.1-1.11.0
Latency to leave start box in cocaine runway, F4.14.57.31.6-2.11.22.3-2.6-2.72.62.6-2.70.9-1.01.8
Latency to leave start box in cocaine runway, M1.21.22.5-1.51.4-1.6-1.31.00.8-0.9-1.11.10.4-0.6-0.8
Std. dev. time between licks in bursts0.91.12.41.5-1.31.21.2-1.1-1.11.01.0-0.8-0.50.30.3
Total sessions with >9 infusions0.90.92.71.7-1.01.30.9-0.7-0.70.70.7-0.7-1.21.10.0
Short access day 1 total inactive lever presses0.60.71.41.1-1.01.20.9-0.8-0.80.70.7-0.6-0.90.70.1
Short access day 10 total inactive lever presses0.40.50.8-0.30.6-0.2-0.70.70.8-0.8-0.90.8-0.60.6-0.8
Short access day 1 total infusions0.30.31.51.1-0.50.90.4-0.1-0.00.00.1-0.1-1.20.6-0.0
Short access day 10 total infusions1.71.94.62.1-1.61.71.5-1.2-1.11.01.1-1.1-1.70.90.4
Short access total infusions1.01.14.21.8-1.01.40.8-0.4-0.40.30.4-0.3-2.11.3-0.2
Short access day 1 locomotion0.20.20.40.5-0.40.50.4-0.4-0.40.40.6-0.6-0.20.10.4
Short access day 10 total locomotion0.10.10.30.6-0.20.40.1-0.2-0.10.20.2-0.3-0.50.30.1
Short access total locomotion0.40.41.11.1-0.70.70.6-0.7-0.50.60.6-0.6-0.50.30.2
One hour access (0.3 mA shock)0.10.10.3-0.10.4-0.2-0.40.50.4-0.5-0.40.4-0.6-0.0-0.0
Compulsive drug intake0.60.71.7-1.31.1-1.3-1.00.50.3-0.3-0.30.31.0-0.8-0.1
One hour access (shock baseline)0.20.20.5-0.00.3-0.0-0.40.60.6-0.7-0.70.6-0.60.1-0.0
Social response proportion0.91.01.80.10.40.3-0.61.01.1-1.2-1.21.3-1.41.3-1.2
Social responses2.22.85.52.0-2.22.42.1-1.8-1.71.61.7-1.7-0.10.31.1
Social time1.11.42.2-0.41.0-0.6-1.11.41.4-1.5-1.41.3-1.20.8-1.4
Soleus weight0.72.13.3-1.71.8-1.7-1.81.71.6-1.5-1.61.40.5-0.1-0.9
Bone: stiffness10.416.428.9-4.95.2-5.4-5.04.44.1-4.0-4.03.91.7-1.4-1.8
Tibialis anterior weight2.27.627.7-4.12.1-3.1-1.40.3-0.20.20.3-0.45.3-4.82.6
Time to tail flick, vehicle, before self-admin0.60.60.90.8-0.90.80.9-1.0-0.91.00.9-0.8-0.0-0.30.6
Time to tail flick, vehicle, after self-admin0.20.20.6-0.60.7-0.7-0.60.30.2-0.2-0.30.40.3-0.8-0.1
Time to tail flick, test, before self-admin0.80.81.70.3-0.80.50.9-0.9-1.11.00.9-0.81.3-1.00.9
Time to tail flick, test, after self-admin1.01.02.2-1.01.1-0.9-1.11.21.1-1.2-1.31.5-0.20.1-0.6
Delta time to tail flick, vehicle, before/after SA1.01.01.5-0.91.2-0.8-1.21.21.1-1.2-1.21.2-0.40.3-0.8
Delta time to tail flick, test, before/after SA1.31.11.6-0.91.2-0.9-1.21.31.3-1.3-1.21.2-0.70.4-0.7
Tibia length4.512.619.0-3.24.3-3.4-4.44.24.0-4.1-4.04.1-0.91.0-2.8
Ambulatory time before self-admin2.12.14.61.8-1.92.11.8-1.5-1.31.31.3-1.3-0.80.80.4
Ambulatory time after self-admin0.91.03.71.3-0.81.40.6-0.10.0-0.10.1-0.0-1.91.7-0.8
Bone: tissue strength0.80.82.2-1.51.1-1.4-1.00.80.7-0.7-0.70.50.7-0.5-0.3
Total heroin consumption2.02.33.6-1.31.6-1.0-1.71.81.8-1.9-1.71.6-0.80.8-1.7
Bone: trabecular number3.85.98.7-2.42.8-2.4-2.82.93.0-2.9-2.92.6-0.00.5-1.7
Bone: trabecular spacing1.11.42.21.1-1.31.11.3-1.5-1.51.41.5-1.30.3-0.60.9
Bone: trabecular thickness0.30.41.1-0.90.5-0.8-0.40.30.2-0.2-0.20.20.9-1.10.4
Bone: trabecular tissue density1.82.56.6-0.3-0.3-1.10.6-1.4-1.71.81.7-1.62.6-2.41.7
Water consumed over 24 hours1.31.54.70.20.50.2-0.81.11.3-1.2-1.21.2-1.72.2-1.5
Number of responses in last shaping day0.10.10.5-0.40.4-0.7-0.30.30.2-0.3-0.40.5-0.3-0.1-0.0