Hub : Genes

Bin2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Bin2 0.03 0.03 1.1e-03 0.03 0.02 0.01 0.01 6.4e-04 2.5e-03 6.8e-03 7.2e-03
2 IC gene expression Bin2 0.13 0.08 1.2e-03 0.07 0.06 0.07 0.05 7.9e-04 1.8e-03 9.6e-04 2.9e-03
3 NAcc gene expression Bin2 0.14 0.06 4.4e-16 0.12 0.12 0.12 0.12 1.3e-17 3.4e-17 9.5e-18 6.8e-18
4 Liver gene expression Bin2 0.54 0.18 0.0e+00 0.16 0.16 0.17 0.17 5.8e-18 1.6e-17 1.3e-18 1.3e-18
5 pVTA intron excision ratio chr7_133639481_133646864 0.35 0.19 9.5e-04 0.03 0.02 0.01 0.03 8.5e-04 5.4e-03 3.1e-02 4.1e-03
6 Brain gene expression Bin2 0.2 0.09 1.0e-13 0.16 0.16 0.15 0.16 7.6e-15 9.0e-15 4.3e-14 9.5e-15
7 PL gene expression Bin2 0.11 0.06 1.2e-07 0.09 0.08 0.09 0.09 6.5e-10 6.1e-09 1.3e-09 1.5e-09
8 pVTA gene expression Bin2 0.17 0.09 1.3e-09 0.12 0.12 0.13 0.13 1.1e-09 4.6e-10 1.2e-10 1.2e-10
9 BLA gene expression Bin2 0.14 0.08 4.7e-04 0.07 0.05 0.03 0.06 8.8e-05 7.7e-04 7.1e-03 3.7e-04
10 pVTA intron excision ratio chr7_133652242_133652838 0.31 0.19 4.8e-04 0.03 0.03 0.02 0.03 4.2e-03 3.2e-03 1.3e-02 2.0e-03
11 IL gene expression Bin2 0.34 0.17 6.3e-05 0.22 0.23 0.29 0.22 4.2e-06 2.8e-06 1.3e-07 6.2e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density5.18.811.23.23.33.33.2-3.33.23.23.33.00.71.4
Area under the delay curve0.20.30.70.90.50.60.6-0.60.60.60.50.20.10.0
BMI with tail3.211.128.15.33.53.33.4-3.33.33.33.33.32.10.3
BMI without tail1.64.87.32.72.42.52.2-2.62.22.22.32.21.40.6
Body weight4.620.131.85.64.94.94.8-4.94.84.74.84.61.51.8
Weight adjusted by age0.61.03.00.9-0.8-0.6-0.80.6-0.8-0.8-0.8-0.71.5-1.7
Bone surface6.612.016.74.13.83.73.7-3.73.83.83.83.70.61.7
Bone volume5.710.213.63.73.53.53.4-3.53.53.43.53.31.11.4
Breakpoint value in progressive ratio session0.60.71.10.81.01.00.9-0.90.90.91.00.7-0.10.8
Number of licking bursts1.62.63.5-1.8-1.7-1.7-1.91.7-1.8-1.8-1.7-1.70.1-0.7
Context. condit. distance diff. score1.01.22.01.11.11.21.2-1.11.21.31.11.4-0.20.9
Locomotion velocity, session 12.22.33.4-1.7-1.5-1.5-1.71.5-1.8-1.6-1.5-1.7-1.3-0.8
Locomotion distance, session 12.53.24.2-1.8-1.9-2.0-1.92.0-2.0-1.9-1.8-2.0-0.3-1.3
Locomotion velocity, session 20.20.20.9-0.6-0.3-0.4-0.40.3-0.4-0.4-0.3-0.5-1.0-0.1
Locomotion distance, session 23.04.16.2-2.5-2.2-2.2-2.32.2-2.1-2.2-2.1-2.3-0.6-1.2
Locomotion velocity, session 31.61.96.2-2.5-1.2-1.1-1.21.1-1.3-1.2-1.1-1.1-1.80.6
Locomotion distance, session 30.80.93.2-1.80.50.60.3-0.60.30.30.50.3-1.81.5
Stereotopy head waving bouts, day 32.63.14.0-0.6-1.8-1.9-2.01.9-1.9-2.0-1.9-1.81.5-1.8
Stereotopy head waving duration, day 31.11.31.8-0.9-1.2-1.3-1.31.3-1.3-1.3-1.2-1.20.4-0.6
Locomotion velocity, session 70.50.63.2-1.8-0.1-0.0-0.20.0-0.2-0.1-0.0-0.0-1.21.1
Locomotion distance, session 70.91.25.3-2.3-0.5-0.4-0.60.4-0.6-0.6-0.4-0.4-2.21.1
Stereotopy head waving bouts, day 71.11.35.91.0-0.7-0.8-0.70.8-0.7-0.6-0.8-0.72.4-1.7
Stereotopy head waving duration, day 70.70.83.71.1-0.5-0.5-0.40.6-0.4-0.4-0.6-0.51.9-1.3
Locomotion velocity, session 80.20.20.4-0.4-0.6-0.6-0.50.6-0.4-0.4-0.6-0.3-0.1-0.2
Locomotion distance, session 80.20.31.4-0.9-0.6-0.5-0.40.5-0.3-0.3-0.4-0.3-1.20.1
Degree of sensitization distance0.60.60.90.2-0.9-0.9-0.81.0-0.7-0.7-0.8-0.70.5-0.8
Degree of sensitization stereotypy0.70.84.01.4-0.4-0.4-0.20.4-0.2-0.1-0.4-0.22.0-1.4
Conditioned locomotion0.10.10.6-0.8-0.2-0.00.00.0-0.1-0.1-0.1-0.1-0.30.4
Cocaine response after cond. corrected0.60.71.0-0.4-1.0-0.8-0.90.8-0.9-0.9-1.0-0.80.4-0.8
Cocaine response after cond. not corrected0.30.30.5-0.6-0.7-0.6-0.70.5-0.6-0.6-0.7-0.60.1-0.4
Cocaine response before conditioning0.30.41.7-1.10.20.20.0-0.20.10.10.30.1-1.30.9
Saline control response0.60.81.4-0.21.01.10.9-1.20.80.91.00.9-0.21.1
Bone: connectivity density3.25.06.52.42.52.52.4-2.52.42.42.52.3-0.31.2
Bone: cortical apparent density2.63.64.7-0.6-2.1-2.0-1.82.0-1.9-1.9-2.1-2.01.7-2.2
Bone: cortical area4.46.88.93.02.92.92.7-2.92.72.73.02.70.81.3
Bone: cortical porosity1.41.51.90.41.31.31.3-1.31.21.41.41.2-0.91.4
Bone: cortical porosity1.21.32.00.11.31.21.2-1.21.11.31.31.1-0.91.4
Bone: cortical thickness1.32.23.51.91.61.61.4-1.71.41.51.71.50.60.7
Bone: cortical thickness0.30.40.7-0.30.80.70.4-0.80.30.40.80.5-0.70.7
Bone: cortical tissue density2.73.64.7-0.7-2.1-2.1-1.82.1-1.9-1.9-2.2-2.01.6-2.1
Condit. Reinf. active minus inactive responses0.00.00.10.4-0.2-0.1-0.00.1-0.1-0.0-0.0-0.00.1-0.2
Condit. Reinf. active-inactive response ratio0.70.70.90.70.90.90.9-0.90.80.91.00.9-0.40.7
Condit. Reinf. active responses0.50.71.0-0.3-1.0-0.9-0.90.9-0.9-0.9-0.9-0.90.1-0.8
Condit. Reinf. inactive responses3.54.35.9-1.7-2.2-2.2-2.32.2-2.3-2.4-2.2-2.30.3-1.6
Incentive salience index mean0.10.10.60.8-0.1-0.0-0.00.0-0.1-0.10.0-0.10.4-0.6
Condit. Reinf. lever presses0.30.41.61.2-0.2-0.2-0.20.2-0.2-0.3-0.1-0.31.0-1.3
Condit. Reinf. active minus inactive responses0.30.41.81.30.50.40.4-0.40.30.40.50.40.8-0.3
Condit. Reinf. active-inactive response ratio0.30.31.01.00.60.60.5-0.60.40.40.60.50.4-0.0
Condit. Reinf. active responses0.10.10.60.70.20.10.2-0.10.10.10.10.10.8-0.4
Condit. Reinf. inactive responses0.20.30.5-0.4-0.6-0.7-0.50.7-0.4-0.5-0.7-0.50.4-0.5
Condit. Reinf. lever presses0.50.71.8-0.30.80.80.7-0.80.60.60.80.6-1.21.3
Condit. Reinf. lever reinforcers received0.00.00.10.40.20.10.1-0.10.10.10.10.10.2-0.1
Conditioned reinforcement - actives0.20.41.6-1.3-0.4-0.3-0.50.3-0.4-0.6-0.4-0.8-0.60.2
Conditioned reinforcement - inactives1.42.06.2-2.5-1.0-1.3-1.61.3-1.5-1.6-1.0-1.6-1.10.2
Conditioned locomotion0.10.20.7-0.90.0-0.0-0.10.00.0-0.10.1-0.3-0.90.7
Patch foraging indifference point 0 sec0.71.36.0-2.4-0.9-1.0-1.01.0-1.0-0.9-0.8-0.8-0.90.4
Patch foraging indifference point AUC1.42.02.8-0.9-1.5-1.5-1.61.4-1.7-1.7-1.5-1.60.6-1.1
Delay disc. indifference point, 0s delay0.80.91.61.20.81.11.2-1.01.21.30.90.6-0.20.4
Delay disc. indifference point, 16s delay0.50.50.90.80.90.80.8-0.80.80.80.90.6-0.20.4
Delay disc. indifference point, 2s delay1.01.15.71.4-0.6-0.3-0.20.3-0.2-0.2-0.6-0.62.4-1.8
Delay disc. indifference point, 24s delay0.00.10.40.60.20.20.1-0.20.10.10.2-0.10.0-0.2
Delay disc. indifference point, 4s delay0.40.41.01.00.70.80.6-0.80.60.70.70.10.30.0
Delay disc. indifference point, 8s delay1.01.21.80.81.11.21.3-1.11.31.31.20.9-0.51.0
Indifference point function ln k2.44.35.72.42.32.22.2-2.22.32.32.32.20.20.8
Indifference point function log k2.44.35.72.42.32.22.2-2.22.32.32.32.20.20.8
Patch foraging total patch changes 0 sec0.61.16.1-2.5-0.7-0.8-0.80.7-0.8-0.8-0.6-0.6-1.10.7
Patch foraging total patch changes 12 sec2.12.74.8-2.2-1.7-1.7-1.91.7-1.9-1.9-1.7-1.7-0.4-0.6
Patch foraging total patch changes 18 sec1.82.76.2-2.5-1.6-1.7-1.81.6-1.8-1.8-1.6-1.7-0.7-0.2
Patch foraging total patch changes 24 sec0.71.13.6-1.9-1.0-0.9-1.20.8-1.2-1.2-0.9-1.0-0.40.0
Patch foraging total patch changes 6 sec2.33.67.1-2.7-2.0-2.0-2.02.0-2.1-2.1-1.9-1.9-0.7-0.5
Patch foraging time to switch 0 sec0.81.72.2-1.5-1.5-1.4-1.31.4-1.4-1.3-1.5-1.40.4-0.9
Patch foraging water rate 0 sec1.83.95.22.32.12.12.1-2.12.22.02.12.10.01.3
Patch foraging water rate 12 sec1.42.94.01.81.71.81.9-1.82.01.91.81.8-0.51.0
Patch foraging water rate 18 sec0.10.10.20.40.10.20.4-0.20.40.30.10.3-0.20.1
Patch foraging water rate 24 sec1.62.24.42.11.41.51.7-1.41.81.61.41.70.40.6
Patch foraging water rate 6 sec3.95.77.82.82.52.62.6-2.62.72.62.52.6-0.21.5
Seeking ratio, delayed vs. immediate footshock0.20.31.01.00.50.40.7-0.30.60.70.50.4-0.2-0.1
Distance traveled before self-admin0.91.22.2-1.5-1.1-1.3-1.11.3-1.0-1.0-1.2-1.2-0.5-0.1
Distance traveled after self-admin0.60.74.1-1.00.20.20.4-0.20.40.40.20.4-2.01.4
Extensor digitorum longus weight1.66.332.64.90.90.80.8-0.80.80.80.70.95.7-2.6
Bone: elastic displacement2.83.38.2-2.9-1.8-1.8-1.61.9-1.6-1.6-1.8-1.6-2.10.2
Bone: elastic work0.40.53.5-0.70.20.20.3-0.20.20.30.30.3-1.91.1
Bone: endosteal estimation5.311.714.83.43.93.83.7-3.83.83.73.83.60.51.9
Bone: endosteal perimeter4.39.111.73.23.43.43.1-3.43.23.23.43.11.11.5
Epididymis fat weight2.07.09.50.92.72.72.7-2.82.62.62.82.6-2.93.1
Delta time in closed arm before/after self-admin0.20.20.30.20.50.40.5-0.30.50.50.50.5-0.20.6
Delta time in open arm before/after self-admin0.60.52.9-1.10.20.30.2-0.30.20.20.20.5-1.71.2
Diff in mean of infusions in LGA sessions0.40.51.61.30.60.40.6-0.40.60.60.50.71.1-0.3
Delay discount exponential model param0.20.20.8-0.9-0.4-0.5-0.50.5-0.5-0.5-0.4-0.1-0.20.1
Extinction: sum of active levers before priming0.91.03.92.01.00.91.0-0.91.01.00.80.90.8-0.3
Active lever presses in extinction session 60.80.71.70.21.11.20.6-1.30.60.60.80.5-0.91.0
Bone: final force8.713.918.04.24.04.14.1-4.14.14.14.03.90.02.1
Bone: final moment10.016.119.64.44.44.44.4-4.44.44.44.44.2-0.02.4
Food consumed during 24 hour testing period2.33.24.21.81.81.82.0-1.72.12.11.81.9-1.11.3
Glucose0.10.10.2-0.3-0.2-0.2-0.50.2-0.4-0.3-0.2-0.3-0.30.0
Heart weight1.72.63.30.91.81.81.8-1.81.71.71.81.7-0.81.7
Delay discount hyperbolic model param0.20.20.7-0.8-0.2-0.4-0.40.4-0.4-0.4-0.3-0.0-0.40.2
Intermittent access intake day 1-15 change0.81.72.00.41.41.41.4-1.41.41.41.41.2-1.11.3
Intermittent access intake escalation0.91.92.40.81.51.61.5-1.61.61.51.51.3-0.61.1
Intermittent access intake escalation 21.01.21.50.41.11.01.2-0.91.21.21.11.2-1.01.2
Intermitt. access day 1 inactive lever presses0.20.61.0-0.3-0.8-0.8-0.90.8-0.9-0.8-0.8-1.00.3-0.7
Intermitt. access day 15 inactive lever presses0.00.10.3-0.50.10.4-0.2-0.5-0.2-0.10.10.2-0.30.2
Intermitt. access escalation Index1.31.84.00.1-1.3-1.5-1.21.5-1.2-1.2-1.4-1.21.4-2.0
Intermittent access day 1 total infusions0.40.62.7-1.6-0.7-0.6-0.70.6-0.6-0.8-0.7-0.7-0.50.3
Intermittent access day 15 total infusions0.10.20.8-0.90.10.20.2-0.20.30.20.10.2-0.50.8
Intermittent access terminal intake (last 3 days)0.10.21.0-1.0-0.0-0.10.10.10.20.1-0.00.0-0.40.7
Intermittent access total infusions0.20.31.7-1.3-0.3-0.3-0.20.3-0.0-0.2-0.3-0.3-0.40.7
Intermittent access day 1 locomotion0.40.52.6-1.6-0.3-0.4-0.50.3-0.4-0.6-0.3-0.6-1.00.5
Intermittent access day 15 total locomotion1.01.84.2-1.11.41.30.9-1.41.00.91.40.6-2.12.0
Intermittent access total locomotion0.60.84.1-2.0-0.1-0.2-0.50.2-0.4-0.5-0.1-0.8-1.40.9
Intermittent access standard deviation0.71.53.7-0.50.90.91.2-0.81.21.10.91.3-1.91.9
Left kidney weight1.57.110.23.02.93.12.9-3.22.82.92.92.60.41.2
Right kidney weight3.114.024.75.03.94.14.0-4.14.04.03.93.71.21.2
Cocaine induced anxiety2.23.24.31.82.11.92.0-1.92.02.02.01.80.01.1
Post-drug Anxiety4.04.36.41.82.52.22.2-2.22.22.32.42.0-0.41.6
Baseline Anxiety0.00.00.00.20.00.0-0.1-0.0-0.1-0.00.1-0.10.2-0.2
Tail length0.41.63.0-0.21.41.61.2-1.71.21.21.41.3-0.21.6
Length with tail1.56.58.82.32.82.92.8-3.02.82.82.82.70.41.7
Length without tail3.210.316.24.03.53.33.6-3.33.53.53.43.30.41.5
Times rat made contact with spout0.40.50.90.40.70.60.7-0.50.70.70.70.6-0.90.7
Lifetime Intake0.40.53.2-1.8-0.4-0.4-0.20.4-0.1-0.3-0.4-0.4-0.91.0
Liver weight, left8.614.217.74.14.24.14.1-4.24.14.24.13.90.12.2
Liver weight, right3.76.59.32.22.93.02.7-3.02.62.72.82.6-0.31.9
Locomotor activity0.30.51.2-1.1-0.5-0.6-0.90.5-0.7-0.9-0.5-0.9-0.8-0.1
Locomotor testing distance0.81.43.3-1.8-1.0-1.1-1.41.0-1.2-1.3-0.9-1.3-1.1-0.1
Locomotor testing rearing0.10.21.1-1.10.00.0-0.2-0.00.10.10.10.1-1.00.7
Locomotion in novel chamber2.73.45.12.32.02.01.9-1.92.01.91.92.21.00.8
Locomotion in novel chamber post-restriction0.30.50.80.20.80.80.7-0.80.70.60.80.5-0.70.9
Fecal boli incidents, locomotor time 10.40.53.8-0.80.00.20.1-0.20.20.20.10.2-2.01.0
Change in fecal boli incidents, locomotor task0.70.71.2-0.1-0.5-0.6-1.00.5-1.0-1.0-0.6-1.11.1-0.9
Time >=10cm from walls, locomotor time 10.20.20.8-0.9-0.2-0.4-0.40.4-0.4-0.4-0.2-0.4-0.40.4
Bouts of movement, locomotor time 10.50.61.2-0.2-0.9-0.8-0.80.8-0.7-0.8-0.8-1.1-0.2-0.6
Total resting periods, locomotor time 11.31.42.3-0.9-1.4-1.3-1.31.3-1.2-1.3-1.3-1.5-0.5-0.6
Rest time, locomotor task time 10.60.81.2-1.1-1.0-0.8-1.10.8-1.0-0.9-1.0-0.8-0.50.0
Distance moved, locomotor task time 10.10.10.2-0.2-0.5-0.4-0.20.4-0.3-0.4-0.5-0.10.5-0.4
Vertical activity count, locomotor time 10.30.71.71.10.90.70.8-0.70.80.70.71.11.3-0.2
Time >=10cm from walls, locomotor time 20.10.20.7-0.8-0.4-0.3-0.30.3-0.3-0.3-0.4-0.3-0.60.5
Bouts of movement, locomotor time 21.01.63.41.81.31.11.4-1.01.41.41.21.21.10.1
Total resting periods, locomotor time 20.91.64.02.01.31.11.3-1.01.31.31.11.01.4-0.1
Rest time, locomotor task time 20.40.50.8-0.4-0.8-0.8-0.70.8-0.8-0.7-0.9-0.90.2-0.3
Distance moved, locomotor task time 20.10.20.4-0.3-0.6-0.4-0.40.4-0.4-0.5-0.6-0.10.1-0.5
Vertical activity count, locomotor time 20.10.10.50.40.30.40.2-0.40.30.20.30.70.3-0.3
Light reinforcement 10.82.03.4-1.5-1.4-1.5-1.81.4-1.8-1.7-1.4-1.5-0.3-0.5
Light reinforcement 20.00.10.2-0.0-0.2-0.2-0.40.1-0.5-0.2-0.1-0.3-0.1-0.2
Bone: marrow area5.211.314.53.33.83.83.6-3.83.73.73.83.50.41.9
Bone: maximum diameter1.32.43.61.51.81.81.4-1.81.51.51.91.60.70.9
Bone: maximum force7.312.922.24.73.93.93.8-3.93.83.83.93.60.91.5
Bone: maximum moment8.715.323.34.84.24.24.2-4.24.24.24.24.00.71.9
Mean time between licks in bursts0.51.21.7-1.3-1.2-1.1-1.21.1-1.2-1.2-1.1-1.1-1.0-0.1
Mean num. licks in bursts2.64.05.31.62.12.12.3-2.12.32.22.22.2-1.01.5
Cd content in liver0.10.10.5-0.7-0.3-0.3-0.30.3-0.3-0.3-0.2-0.1-0.20.3
Co content in liver0.10.10.30.10.00.0-0.1-0.1-0.1-0.1-0.1-0.10.6-0.5
Cu content in liver1.21.42.10.51.41.41.4-1.41.31.31.41.2-0.10.8
Fe content in liver0.70.83.7-1.9-0.8-0.8-0.90.8-0.9-0.8-0.8-0.6-0.50.5
K content in liver0.00.00.00.10.10.10.1-0.1-0.00.00.1-0.0-0.0-0.2
Mg content in liver0.00.00.2-0.2-0.0-0.1-0.20.0-0.3-0.2-0.0-0.3-0.4-0.1
Mn content in liver0.30.41.00.4-0.6-0.6-0.50.6-0.5-0.5-0.6-0.70.6-1.0
Na content in liver0.70.81.30.60.90.91.1-0.91.01.11.01.0-0.50.6
Rb content in liver0.10.21.0-1.0-0.0-0.0-0.1-0.0-0.2-0.2-0.00.0-0.60.6
Se content in liver1.21.43.4-1.8-1.2-1.2-1.21.2-1.3-1.1-1.2-1.2-0.90.1
Sr content in liver1.41.21.70.71.11.21.3-1.11.31.31.21.2-0.40.8
Zn content in liver0.20.31.3-1.1-0.2-0.2-0.20.2-0.2-0.3-0.2-0.2-1.00.5
Bone: minimum diameter4.07.410.13.23.02.92.8-2.92.92.93.02.81.11.2
Time in familiar zone, hab. session 10.20.20.40.6-0.4-0.4-0.40.4-0.5-0.5-0.4-0.3-0.0-0.7
Time in novel zone, hab. session 10.10.10.5-0.5-0.3-0.2-0.20.2-0.2-0.2-0.3-0.20.70.0
Total zone transitions, hab. session 12.33.15.7-0.3-2.0-1.8-1.81.8-1.7-1.8-1.9-1.81.5-2.4
Total locomotion distance, hab. session 11.01.41.9-0.8-1.4-1.3-1.31.2-1.3-1.3-1.3-1.4-0.1-1.2
Locomotion velocity, hab. session 10.71.01.4-0.6-1.2-1.1-1.11.1-1.1-1.1-1.1-1.2-0.1-1.1
Time in familiar zone, hab. session 21.31.43.11.81.21.21.2-1.21.21.31.11.2-0.30.4
Time in novel zone, hab. session 21.81.83.1-1.8-1.5-1.4-1.41.4-1.4-1.4-1.4-1.30.7-0.6
Total zone transitions, hab. session 20.50.61.0-0.8-1.0-0.9-0.80.9-0.8-0.8-0.8-0.9-0.3-0.6
Total locomotion distance, hab. session 20.70.91.5-1.2-1.1-1.0-1.01.0-1.0-1.0-0.9-1.1-0.4-0.5
Locomotion velocity, hab. session 20.40.51.1-1.1-0.8-0.7-0.70.7-0.6-0.6-0.5-0.8-0.6-0.2
Novel to familiar place preference ratio0.40.42.51.20.00.10.2-0.00.40.20.00.21.6-0.6
Novelty place preference0.30.32.01.0-0.2-0.10.10.20.2-0.0-0.20.11.4-0.6
Time in novel zone, NPP test0.40.42.30.8-0.4-0.4-0.20.4-0.1-0.2-0.4-0.11.5-0.8
Total zone transitions, NPP test3.04.35.9-2.2-2.3-2.2-2.32.2-2.3-2.2-2.1-2.4-0.5-1.5
Total locomotion distance, NPP test3.54.87.1-2.7-2.3-2.3-2.42.3-2.4-2.2-2.1-2.4-1.3-0.9
Locomotion velocity, NPP test2.33.25.1-2.3-1.9-1.9-1.91.8-2.0-1.8-1.7-2.0-1.4-0.6
Intraocular pressure1.31.95.8-2.4-1.4-1.5-1.11.5-1.1-1.3-1.3-1.1-1.40.2
Delta distance traveled before/after self-admin3.33.55.50.31.91.91.8-2.01.81.81.82.0-2.32.3
Delta ambulatory time before/after self-admin2.32.95.00.11.61.71.6-1.71.61.61.71.7-2.22.1
Parametrial fat weight0.20.63.7-1.1-0.4-0.3-0.50.3-0.5-0.5-0.2-0.5-1.90.3
Pavlov. Cond. lever latency0.20.31.2-1.1-0.2-0.1-0.10.1-0.1-0.0-0.20.0-1.00.8
Pavlov. Cond. magazine entry latency0.50.72.51.60.50.50.6-0.50.70.60.50.61.5-0.3
Pavlov. Cond. change in total contacts0.70.83.41.80.30.40.4-0.40.60.40.30.31.7-1.0
Pavlov. Cond. index score0.70.83.41.80.40.40.5-0.40.50.40.40.41.8-0.9
Pavlov. Cond. latency score0.60.83.31.80.40.40.5-0.40.60.50.40.41.7-0.9
Pavlov. Cond. lever contacts0.20.31.21.10.30.30.3-0.30.30.20.30.11.0-0.7
Pavlov. Cond. magazine entry number0.40.51.8-1.3-0.5-0.5-0.60.5-0.6-0.5-0.5-0.6-1.20.2
Pavlov. Cond. intertrial magazine entries2.32.75.1-2.3-1.7-1.7-1.61.7-1.8-1.7-1.6-1.6-1.5-0.3
Pavlov. Cond. lever-magazine prob. diff.0.70.83.71.90.40.40.5-0.40.60.40.40.41.7-0.9
Pavlov. Cond. response bias0.20.20.91.00.30.30.3-0.40.40.30.40.30.8-0.2
Pavlov. Cond. lever latency0.50.72.71.60.30.30.5-0.20.50.50.30.51.5-1.0
Pavlov. Cond. magazine entry latency0.50.62.6-1.3-0.2-0.3-0.50.3-0.5-0.5-0.2-0.4-1.60.7
Pavlov. Cond. change in total contacts0.10.20.90.8-0.00.00.0-0.10.00.0-0.1-0.00.9-0.5
Pavlov. Cond. index score0.30.51.7-1.3-0.3-0.3-0.40.2-0.4-0.5-0.3-0.4-1.30.8
Pavlov. Cond. latency score0.40.51.7-1.3-0.4-0.4-0.50.3-0.5-0.5-0.3-0.5-1.30.7
Pavlov. Cond. lever contacts0.40.62.5-1.6-0.2-0.1-0.40.1-0.3-0.4-0.2-0.3-1.51.1
Pavlov. Cond. magazine entry number0.10.21.10.5-0.10.00.20.00.20.2-0.20.11.1-0.5
Pavlov. Cond. intertrial magazine entries0.60.92.1-0.70.80.80.9-0.71.01.00.80.9-1.31.4
Pavlov. Cond. lever-magazine prob. diff.0.20.31.2-1.1-0.3-0.3-0.40.2-0.4-0.4-0.2-0.4-1.10.6
Pavlov. Cond. response bias0.40.63.0-1.3-0.0-0.0-0.3-0.0-0.2-0.30.0-0.2-1.71.1
Time in closed arm before self-admin0.50.63.71.2-0.2-0.2-0.10.2-0.1-0.1-0.2-0.01.9-1.4
Time in closed arm after self-admin0.70.73.10.7-0.7-0.6-0.50.7-0.5-0.5-0.5-0.71.8-1.3
Time in open arm before self-admin1.61.83.4-0.7-1.4-1.3-1.41.3-1.4-1.4-1.4-1.80.7-1.4
Time in open arm after self-admin0.20.20.4-0.6-0.3-0.4-0.40.3-0.4-0.4-0.4-0.3-0.6-0.1
Bone: periosteal estimation7.114.919.04.04.34.34.1-4.44.14.24.34.00.92.2
Bone: periosteal perimeter5.49.212.33.53.53.43.1-3.53.13.13.53.01.61.2
Bone: post-yield work3.95.77.02.62.52.62.6-2.62.62.62.62.50.11.4
Progressive ratio test 1 active lever presses2.42.99.9-3.1-1.7-1.7-1.41.7-1.3-1.5-1.6-1.7-1.40.4
Progressive ratio test 1 breakpoint2.22.79.6-3.1-1.5-1.6-1.41.6-1.2-1.4-1.5-1.6-1.50.6
Progressive ratio test 1 inactive lever presses0.50.71.6-1.0-0.7-0.7-0.90.7-0.8-1.0-0.7-1.3-0.0-0.4
Progressive ratio test 2 active lever presses0.40.42.7-1.6-0.5-0.3-0.40.3-0.2-0.5-0.4-0.9-0.40.3
Progressive ratio test 2 breakpoint0.40.42.4-1.6-0.5-0.4-0.40.3-0.2-0.6-0.5-0.9-0.20.2
Progressive ratio test 2 inactive lever presses0.20.31.3-1.10.30.30.1-0.40.20.10.3-0.3-1.00.8
Incentive Sensitization - Responses0.40.51.20.70.81.00.6-1.10.80.40.80.10.8-0.2
Incentive Sensitization - Breakpoint0.30.40.90.60.70.90.6-0.90.70.30.70.10.9-0.3
Sum of active levers in priming session hrs 5-60.20.20.6-0.2-0.3-0.4-0.60.3-0.6-0.6-0.5-0.80.2-0.5
Progressive ratio1.11.72.2-1.5-1.4-1.4-1.51.4-1.4-1.5-1.4-1.4-0.4-0.6
Food seeking constrained by brief footshock1.41.74.0-2.0-1.4-1.4-1.21.4-1.2-1.3-1.5-1.3-0.7-0.2
Seeking ratio, punishment vs. effort0.10.20.30.30.30.30.6-0.30.60.50.30.4-0.00.2
Retroperitoneal fat weight0.41.914.5-1.40.30.20.2-0.20.20.20.40.3-3.81.9
Reaction time number correct2.64.97.01.52.42.32.6-2.22.62.52.42.5-0.61.9
Reaction time mean minus median0.82.14.7-2.2-1.4-1.5-1.61.5-1.4-1.5-1.5-1.5-0.7-0.5
Reaction time mean minus median AUC0.71.92.7-1.6-1.5-1.6-1.51.6-1.3-1.4-1.6-1.4-0.2-0.8
Reaction time num false alarms1.72.43.3-1.6-1.7-1.6-1.81.6-1.8-1.8-1.6-1.7-0.0-1.0
Reaction time num false alarms AUC2.43.75.2-1.7-2.1-2.1-2.32.0-2.2-2.3-2.0-2.10.2-1.3
Reaction time trials correct on left2.64.97.01.52.42.32.6-2.22.62.52.42.5-0.61.9
Reaction time trials on left2.44.66.61.42.32.22.6-2.12.52.42.32.4-0.61.9
Reaction time mean0.10.11.0-1.0-0.1-0.1-0.20.1-0.1-0.0-0.2-0.1-0.20.4
Reaction time mean AUC0.00.10.5-0.70.10.10.0-0.00.20.20.00.1-0.10.4
Median of all reaction times0.20.20.5-0.30.50.50.4-0.50.50.60.50.5-0.00.7
Reaction time omissions3.04.49.7-3.1-2.3-2.2-2.12.3-2.1-2.0-2.2-2.1-0.8-0.7
Reaction time false alarm rate5.17.19.9-1.9-2.9-2.8-3.12.7-3.1-3.1-2.8-2.90.7-2.2
Reaction time premature initiation rate0.81.13.0-1.7-1.0-1.1-0.71.1-0.9-0.8-1.0-0.8-1.30.3
Reaction time premature initiations0.40.72.6-0.80.30.20.8-0.10.70.70.40.7-1.61.4
Std. dev. reaction times1.52.75.0-2.2-1.7-1.8-1.81.8-1.7-1.7-1.8-1.7-0.5-0.7
Reaction time trials completed2.44.66.61.42.32.22.6-2.12.52.42.32.4-0.61.9
Reaction time trials AUC2.75.27.41.72.52.42.7-2.32.72.62.52.6-0.41.8
Run reversals in cocaine runway, females0.80.81.40.61.01.00.9-1.10.90.91.01.2-0.20.5
Run reversals in cocaine runway, males1.01.02.7-0.5-1.0-0.7-1.00.7-0.9-0.9-1.0-1.01.6-1.3
Latency to leave start box in cocaine runway1.01.11.5-0.2-1.1-1.2-1.21.2-1.2-1.2-1.1-1.00.3-1.1
Latency to leave start box in cocaine runway, F2.63.04.3-1.2-1.8-1.9-2.01.8-2.0-2.0-1.8-2.10.4-1.5
Latency to leave start box in cocaine runway, M0.50.51.81.30.60.40.6-0.30.60.60.61.20.20.1
Std. dev. time between licks in bursts0.91.23.1-1.7-1.1-1.0-1.11.0-1.1-1.2-1.0-1.1-1.00.1
Total sessions with >9 infusions1.31.64.4-2.1-1.3-1.2-1.31.3-1.1-1.3-1.3-1.4-0.6-0.0
Short access day 1 total inactive lever presses0.70.92.4-1.5-0.8-1.2-0.81.2-0.7-0.9-0.8-1.1-0.60.1
Short access day 10 total inactive lever presses0.00.00.10.30.40.00.2-0.00.20.20.30.20.10.1
Short access day 1 total infusions0.40.52.4-1.60.00.00.20.00.30.10.0-0.1-1.11.3
Short access day 10 total infusions0.70.93.4-1.8-1.0-0.9-0.90.9-0.8-0.9-1.0-1.0-0.20.1
Short access total infusions0.81.05.8-2.4-0.6-0.6-0.50.7-0.3-0.5-0.6-0.6-1.41.1
Short access day 1 locomotion0.20.20.9-0.9-0.3-0.4-0.40.4-0.4-0.4-0.4-0.7-0.30.2
Short access day 10 total locomotion0.10.10.9-1.00.1-0.1-0.20.2-0.2-0.30.1-0.4-0.10.4
Short access total locomotion0.50.62.4-1.5-0.4-0.6-0.70.7-0.6-0.7-0.4-0.8-0.60.4
One hour access (0.3 mA shock)0.70.81.30.51.00.91.0-0.91.10.90.91.10.30.7
Compulsive drug intake0.10.10.60.40.20.0-0.2-0.1-0.1-0.30.1-0.00.8-0.7
One hour access (shock baseline)0.60.91.60.61.01.01.2-0.91.31.21.01.00.00.9
Social response proportion0.80.92.0-0.10.80.91.0-0.90.91.00.90.9-1.41.2
Social responses1.92.53.8-2.0-1.8-1.7-1.61.7-1.8-1.6-1.8-1.6-0.2-0.5
Social time1.52.12.80.51.51.51.5-1.51.41.51.51.5-1.41.7
Soleus weight0.61.92.81.61.71.61.3-1.71.31.31.51.5-0.10.8
Bone: stiffness8.313.524.75.03.94.03.8-4.03.93.83.93.71.71.2
Tibialis anterior weight1.86.239.34.0-0.3-0.4-0.30.4-0.3-0.4-0.5-0.26.3-3.4
Time to tail flick, vehicle, before self-admin0.80.81.4-1.2-1.0-0.9-1.01.0-1.0-1.0-0.9-0.9-0.4-0.1
Time to tail flick, vehicle, after self-admin0.10.11.20.50.10.0-0.0-0.00.00.00.2-0.11.1-0.1
Time to tail flick, test, before self-admin0.70.71.0-0.5-1.0-0.9-0.90.8-0.9-0.9-0.8-0.50.8-1.0
Time to tail flick, test, after self-admin0.40.50.90.80.60.70.6-0.70.60.60.71.00.80.1
Delta time to tail flick, vehicle, before/after SA0.90.91.30.81.11.11.0-1.11.01.01.00.90.30.6
Delta time to tail flick, test, before/after SA0.40.50.60.70.80.70.8-0.70.80.80.70.7-0.10.4
Tibia length5.314.518.53.24.34.24.3-4.34.24.24.34.0-0.32.7
Ambulatory time before self-admin1.01.52.8-1.7-1.2-1.4-1.21.5-1.2-1.2-1.3-1.3-0.8-0.0
Ambulatory time after self-admin0.70.94.8-1.30.20.20.3-0.20.30.30.20.3-2.21.5
Bone: tissue strength0.40.41.81.30.50.50.6-0.40.60.60.50.60.7-0.1
Total heroin consumption1.11.31.70.81.31.21.2-1.21.21.21.21.1-0.81.1
Bone: trabecular number3.96.48.42.52.82.82.7-2.82.82.72.92.6-0.21.3
Bone: trabecular spacing1.31.72.2-1.1-1.5-1.4-1.41.4-1.4-1.4-1.5-1.40.5-0.8
Bone: trabecular thickness0.20.31.41.00.10.00.1-0.10.10.10.10.01.2-0.9
Bone: trabecular tissue density2.03.05.20.4-1.7-1.6-1.81.6-1.7-1.7-1.7-1.82.0-2.3
Water consumed over 24 hours1.31.82.30.41.51.41.4-1.31.41.41.51.3-1.31.5
Number of responses in last shaping day0.30.30.7-0.2-0.5-0.8-0.40.8-0.4-0.5-0.5-0.40.7-0.7