Hub : Genes

Stip1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	gene expression	Stip1	0.17	0.1	2.1e-03	0.01	0.04	0.02	0.01	1.8e-01	2.6e-02	1.1e-01	1.3e-01
2	Brain	mRNA stability	Stip1	0.07	0.04	1.4e-04	0	0.03	0.03	0.02	2.0e-01	1.6e-03	1.5e-03	1.1e-02
3	PL	mRNA stability	Stip1	0.04	0.03	7.8e-03	0	0.02	0.01	0.01	1.3e-01	5.2e-03	1.1e-02	5.1e-02
4	Adipose	mRNA stability	Stip1	0.04	0.03	5.6e-03	0.01	0	0.01	0.01	1.3e-02	1.8e-01	2.6e-02	1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.3	0.6	1.2	-1.1	0.7	-0.5	-0.6
Area under the delay curve	0.2	0.3	0.5	-0.4	-0.5	0.7	0.5
BMI with tail	1.1	3.8	10.5	-3.2	1.7	-0.6	-1.3
BMI without tail	0.2	1.1	4.0	-2.0	0.1	0.3	0.5
Body weight	1.4	6.2	17.8	-4.2	2.2	-1.2	-0.8
Weight adjusted by age	0.6	1.7	2.2	-1.5	1.5	-1.3	-0.9
Bone surface	4.1	8.1	9.7	-3.1	3.0	-2.8	-2.5
Bone volume	2.3	4.6	5.5	-1.8	2.3	-2.1	-2.3
Breakpoint value in progressive ratio session	1.8	3.3	4.5	-2.1	1.8	-2.1	-0.9
Number of licking bursts	0.1	0.3	0.4	-0.5	0.5	-0.6	-0.3
Context. condit. distance diff. score	1.2	1.4	2.4	1.1	-1.1	1.6	0.7
Locomotion velocity, session 1	0.6	0.7	0.9	-0.2	-0.9	0.9	0.9
Locomotion distance, session 1	0.3	0.4	0.7	-0.8	-0.4	0.7	0.3
Locomotion velocity, session 2	1.1	1.3	3.5	-1.9	1.0	-0.7	-0.4
Locomotion distance, session 2	0.3	0.5	0.8	-0.9	-0.6	0.5	0.6
Locomotion velocity, session 3	0.7	0.8	2.5	0.2	-0.7	1.6	0.1
Locomotion distance, session 3	0.1	0.1	0.3	-0.0	-0.3	0.6	0.2
Stereotopy head waving bouts, day 3	1.3	1.6	3.5	0.6	-1.4	1.9	0.7
Stereotopy head waving duration, day 3	0.5	0.6	1.1	0.8	-0.8	1.0	0.1
Locomotion velocity, session 7	0.4	0.4	0.9	0.5	-0.6	1.0	-0.1
Locomotion distance, session 7	0.8	1.0	1.9	-0.0	-1.1	1.4	1.0
Stereotopy head waving bouts, day 7	0.6	0.7	1.5	-0.0	0.8	-0.7	-1.2
Stereotopy head waving duration, day 7	1.5	1.9	2.6	-1.0	1.6	-1.4	-1.4
Locomotion velocity, session 8	0.6	0.7	1.3	-1.2	-0.6	0.1	1.0
Locomotion distance, session 8	0.3	0.4	0.9	0.2	-0.9	0.9	0.1
Degree of sensitization distance	0.3	0.3	0.8	-0.1	-0.5	0.9	0.4
Degree of sensitization stereotypy	1.7	1.9	2.6	-0.7	1.5	-1.5	-1.6
Conditioned locomotion	0.6	0.7	1.8	-1.4	0.4	-0.5	0.8
Cocaine response after cond. corrected	1.7	2.5	3.8	1.1	-1.7	1.9	1.4
Cocaine response after cond. not corrected	1.0	1.5	2.4	0.8	-1.3	1.6	1.1
Cocaine response before conditioning	1.5	1.8	2.6	-0.9	1.6	-1.6	-1.1
Saline control response	1.9	2.6	7.1	-2.7	1.5	-1.1	0.2
Bone: connectivity density	1.6	2.5	5.1	-2.3	1.5	-1.3	-1.0
Bone: cortical apparent density	0.1	0.1	0.2	-0.0	0.3	-0.4	0.4
Bone: cortical area	0.9	1.4	2.1	-1.1	1.5	-1.0	-1.2
Bone: cortical porosity	0.1	0.1	0.3	-0.2	0.1	-0.5	0.0
Bone: cortical porosity	0.2	0.3	0.5	-0.7	0.3	-0.7	0.1
Bone: cortical thickness	1.1	1.8	4.5	-2.1	1.2	-1.0	0.6
Bone: cortical thickness	0.9	1.1	2.5	-0.8	-0.7	0.8	1.6
Bone: cortical tissue density	0.1	0.2	0.3	-0.2	0.4	-0.5	0.5
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.4	0.5	-0.1	0.0
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.1	0.4	-0.3	0.0
Condit. Reinf. active responses	0.1	0.1	0.4	-0.1	0.6	-0.0	-0.4
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.3	0.1	0.2	-0.5
Incentive salience index mean	0.2	0.2	0.5	-0.7	0.6	0.0	-0.2
Condit. Reinf. lever presses	0.5	0.7	1.0	-0.9	1.0	-0.6	-0.8
Condit. Reinf. active minus inactive responses	0.3	0.5	0.8	0.4	0.9	-0.7	-0.6
Condit. Reinf. active-inactive response ratio	0.7	1.2	2.2	1.0	0.9	-0.7	-1.5
Condit. Reinf. active responses	0.3	0.4	0.8	-0.2	0.9	-0.8	-0.4
Condit. Reinf. inactive responses	0.3	0.4	0.9	-0.9	-0.1	0.0	0.9
Condit. Reinf. lever presses	2.3	3.3	4.2	-1.6	2.0	-1.9	-1.6
Condit. Reinf. lever reinforcers received	0.6	0.8	1.5	-0.5	1.2	-1.1	-0.6
Conditioned reinforcement - actives	0.7	2.8	5.6	0.2	1.5	-1.8	-2.4
Conditioned reinforcement - inactives	0.9	2.6	6.0	1.9	0.8	-0.3	-2.5
Conditioned locomotion	2.8	4.2	12.5	3.5	-1.2	1.4	-0.8
Patch foraging indifference point 0 sec	0.1	0.2	0.3	0.1	0.6	0.1	-0.5
Patch foraging indifference point AUC	1.7	4.1	5.9	-1.7	2.4	-2.3	-1.5
Delay disc. indifference point, 0s delay	0.9	1.0	1.6	-0.1	-1.3	1.2	0.9
Delay disc. indifference point, 16s delay	0.2	0.3	0.5	0.7	0.2	0.4	-0.5
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	-0.0	-0.2	0.3	-0.2
Delay disc. indifference point, 24s delay	0.3	0.4	0.8	-0.1	-0.5	0.9	0.8
Delay disc. indifference point, 4s delay	1.0	1.0	1.7	-0.4	-0.9	1.3	1.2
Delay disc. indifference point, 8s delay	0.5	0.9	1.4	-0.3	-1.2	0.9	1.2
Indifference point function ln k	3.6	10.8	14.4	3.2	-3.7	3.8	2.1
Indifference point function log k	3.6	10.8	14.4	3.2	-3.7	3.8	2.1
Patch foraging total patch changes 0 sec	0.0	0.1	0.1	0.0	0.3	0.4	-0.0
Patch foraging total patch changes 12 sec	3.1	4.2	6.9	-2.6	2.4	-1.8	-1.0
Patch foraging total patch changes 18 sec	0.7	1.8	2.6	-1.0	1.6	-1.4	-1.3
Patch foraging total patch changes 24 sec	0.7	2.5	4.4	-1.9	2.1	-0.9	-1.0
Patch foraging total patch changes 6 sec	0.4	0.6	2.0	-1.4	0.7	-0.1	-0.1
Patch foraging time to switch 0 sec	0.4	1.6	2.7	-1.7	1.1	-1.2	-1.1
Patch foraging water rate 0 sec	0.8	3.1	7.2	2.7	-1.4	1.8	0.6
Patch foraging water rate 12 sec	2.4	9.6	12.9	3.6	-3.1	3.5	1.9
Patch foraging water rate 18 sec	2.1	4.6	7.2	1.9	-2.4	2.7	1.4
Patch foraging water rate 24 sec	2.6	3.8	5.2	2.3	-2.0	2.1	1.2
Patch foraging water rate 6 sec	4.3	6.3	9.2	2.5	-2.6	3.0	1.8
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.4	0.5	-0.2	0.6	0.2
Distance traveled before self-admin	1.0	2.2	3.3	-1.0	1.8	-1.4	-1.5
Distance traveled after self-admin	0.3	0.5	1.0	-0.4	0.9	-1.0	-0.5
Extensor digitorum longus weight	3.6	14.5	35.4	-6.0	3.6	-2.9	-0.9
Bone: elastic displacement	2.0	2.6	4.1	1.0	-1.6	1.6	2.0
Bone: elastic work	1.0	1.3	2.8	-1.2	-0.5	0.8	1.7
Bone: endosteal estimation	0.3	0.7	1.2	0.8	-0.5	0.9	-1.1
Bone: endosteal perimeter	0.6	1.5	4.5	1.1	-0.0	0.2	-2.1
Epididymis fat weight	0.7	3.5	9.6	3.1	-0.3	1.1	-1.7
Delta time in closed arm before/after self-admin	2.4	2.3	4.2	-0.5	-1.1	1.8	2.1
Delta time in open arm before/after self-admin	2.7	3.1	4.3	-0.6	2.1	-1.9	-2.1
Diff in mean of infusions in LGA sessions	0.3	0.4	0.9	-1.0	0.8	-0.5	0.1
Delay discount exponential model param	0.2	0.3	0.4	0.4	0.4	-0.6	-0.5
Extinction: sum of active levers before priming	1.3	2.0	3.5	-1.9	1.5	-1.2	-0.8
Active lever presses in extinction session 6	4.3	4.4	5.7	-2.0	2.3	-2.4	-1.6
Bone: final force	1.6	2.6	4.8	-2.2	1.6	-1.3	-1.2
Bone: final moment	1.5	2.4	4.6	-2.1	1.6	-1.2	-1.1
Food consumed during 24 hour testing period	0.4	0.8	1.2	0.0	1.0	-0.9	-1.1
Glucose	1.5	2.4	3.8	1.7	-1.8	2.0	-0.1
Heart weight	1.6	2.6	5.1	0.4	-1.8	2.3	1.3
Delay discount hyperbolic model param	0.2	0.2	0.3	0.4	0.4	-0.6	-0.4
Intermittent access intake day 1-15 change	0.2	1.2	2.1	1.5	0.7	-0.7	-1.3
Intermittent access intake escalation	0.3	1.4	2.2	1.3	0.8	-1.0	-1.5
Intermittent access intake escalation 2	0.8	1.4	2.4	1.3	1.0	-0.8	-1.5
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.4	0.6	0.2	-0.5	-0.5
Intermitt. access day 15 inactive lever presses	0.4	2.4	5.4	1.6	1.2	0.0	-2.3
Intermitt. access escalation Index	0.8	2.4	3.4	1.8	-1.6	1.6	1.0
Intermittent access day 1 total infusions	0.5	1.6	2.6	1.6	-0.7	1.2	-1.3
Intermittent access day 15 total infusions	1.2	3.0	7.6	2.8	-0.2	0.3	-2.0
Intermittent access terminal intake (last 3 days)	1.6	2.8	6.1	2.2	0.4	0.2	-2.5
Intermittent access total infusions	1.6	1.9	4.0	2.0	-0.2	0.7	-1.8
Intermittent access day 1 locomotion	0.6	1.0	1.9	1.4	-0.6	1.1	-0.9
Intermittent access day 15 total locomotion	0.9	3.3	7.9	2.3	0.5	-0.1	-2.8
Intermittent access total locomotion	3.4	4.0	8.8	2.6	0.4	0.4	-3.0
Intermittent access standard deviation	0.1	0.8	2.2	1.5	0.2	0.1	-0.9
Left kidney weight	0.1	0.6	1.3	1.1	-0.4	0.7	-0.8
Right kidney weight	0.1	0.4	0.9	1.0	-0.1	0.4	-0.7
Cocaine induced anxiety	0.2	0.6	0.9	-0.1	0.8	-0.9	-1.0
Post-drug Anxiety	0.6	0.6	0.8	-0.7	0.9	-0.9	-0.7
Baseline Anxiety	0.4	0.6	1.3	-0.6	-0.5	0.7	1.1
Tail length	0.1	0.8	1.6	-1.3	0.3	-0.3	1.1
Length with tail	0.7	3.0	9.1	-3.0	1.3	-1.1	0.6
Length without tail	0.5	2.5	7.7	-2.8	1.3	-0.6	0.5
Times rat made contact with spout	0.3	0.3	0.6	-0.7	0.0	-0.1	0.8
Lifetime Intake	1.1	1.3	2.8	1.7	-0.6	0.9	-1.1
Liver weight, left	0.8	1.3	1.8	1.0	-1.4	1.3	0.8
Liver weight, right	2.7	4.8	7.6	1.5	-2.6	2.8	1.7
Locomotor activity	2.3	3.5	4.4	1.7	-2.1	2.0	1.7
Locomotor testing distance	2.1	5.2	7.2	1.8	-2.5	2.7	2.0
Locomotor testing rearing	1.1	4.2	5.8	1.7	-2.1	2.4	1.9
Locomotion in novel chamber	1.7	2.3	7.1	2.7	-0.8	1.1	-0.7
Locomotion in novel chamber post-restriction	0.5	1.6	5.3	2.3	-0.6	0.5	-0.6
Fecal boli incidents, locomotor time 1	0.7	1.7	3.0	-0.1	1.3	-1.5	-1.7
Change in fecal boli incidents, locomotor task	1.9	2.0	3.3	0.2	-1.8	1.4	1.6
Time >=10cm from walls, locomotor time 1	1.0	1.3	3.6	0.7	0.5	-0.8	-1.9
Bouts of movement, locomotor time 1	1.3	1.7	3.8	-0.8	1.5	-1.9	-0.5
Total resting periods, locomotor time 1	1.5	1.7	3.5	-0.5	1.6	-1.9	-0.8
Rest time, locomotor task time 1	0.5	0.8	2.7	1.6	-0.6	0.3	-0.1
Distance moved, locomotor task time 1	0.1	0.1	0.6	-0.8	0.1	0.0	-0.1
Vertical activity count, locomotor time 1	0.1	0.7	1.0	0.9	-1.0	0.9	0.3
Time >=10cm from walls, locomotor time 2	0.6	1.6	2.4	0.1	1.3	-1.6	-1.5
Bouts of movement, locomotor time 2	0.1	0.5	0.9	-0.6	1.0	-0.6	-0.3
Total resting periods, locomotor time 2	0.1	0.3	0.6	-0.3	0.8	-0.5	-0.4
Rest time, locomotor task time 2	1.0	1.7	3.4	1.8	-1.4	1.1	0.3
Distance moved, locomotor task time 2	0.6	0.8	1.4	-1.2	0.8	-1.1	-0.0
Vertical activity count, locomotor time 2	0.2	0.5	1.3	0.1	-0.7	0.4	1.1
Light reinforcement 1	0.0	0.1	0.2	0.4	0.5	-0.1	-0.0
Light reinforcement 2	1.0	2.3	5.1	1.4	1.3	-0.7	-2.3
Bone: marrow area	0.3	0.8	1.1	0.9	-0.7	1.0	-0.9
Bone: maximum diameter	1.1	2.1	4.0	-0.6	1.6	-1.3	-2.0
Bone: maximum force	2.5	4.9	6.9	-2.6	2.4	-1.7	-2.1
Bone: maximum moment	2.4	4.5	6.5	-2.5	2.3	-1.6	-1.9
Mean time between licks in bursts	0.3	1.6	3.6	-0.7	-1.0	1.2	1.9
Mean num. licks in bursts	0.2	0.4	0.6	0.4	-0.7	0.7	0.8
Cd content in liver	0.9	1.0	1.9	1.2	0.4	-0.7	-1.4
Co content in liver	2.3	2.7	4.2	1.2	-1.7	1.5	2.0
Cu content in liver	0.0	0.0	0.0	0.2	0.1	-0.2	0.0
Fe content in liver	0.1	0.1	0.3	-0.5	0.0	-0.3	-0.2
K content in liver	0.4	0.4	1.1	-1.1	-0.2	0.5	0.6
Mg content in liver	0.9	1.0	2.0	0.2	-1.0	1.4	0.9
Mn content in liver	3.2	3.6	4.9	-1.9	2.2	-1.9	-1.5
Na content in liver	0.2	0.2	0.6	-0.7	0.5	-0.2	-0.1
Rb content in liver	2.5	2.9	4.0	1.5	-2.0	1.8	1.4
Se content in liver	0.9	1.1	2.3	0.4	1.1	-0.9	-1.5
Sr content in liver	2.5	2.1	3.4	-1.6	1.8	-1.5	-0.8
Zn content in liver	0.3	0.3	0.6	-0.8	0.8	-0.1	0.1
Bone: minimum diameter	0.3	0.6	1.0	0.7	-0.2	0.8	-1.0
Time in familiar zone, hab. session 1	0.1	0.2	0.4	0.3	-0.3	0.6	0.1
Time in novel zone, hab. session 1	0.8	0.9	1.6	0.4	-1.3	0.9	1.0
Total zone transitions, hab. session 1	0.2	0.3	0.6	-0.8	0.5	-0.6	-0.3
Total locomotion distance, hab. session 1	0.2	0.3	0.5	0.6	-0.6	0.7	-0.2
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.1	-0.1	0.3	-0.2
Time in familiar zone, hab. session 2	1.4	1.6	3.5	-0.3	-1.4	1.0	1.9
Time in novel zone, hab. session 2	0.6	0.7	1.4	-0.1	1.0	-0.5	-1.2
Total zone transitions, hab. session 2	0.4	0.5	1.9	-1.4	0.2	0.0	-0.1
Total locomotion distance, hab. session 2	0.4	0.5	1.1	-0.2	-0.8	1.1	0.3
Locomotion velocity, hab. session 2	0.3	0.3	0.8	0.1	-0.7	0.9	-0.0
Novel to familiar place preference ratio	2.6	3.4	4.6	-1.1	2.2	-2.0	-2.0
Novelty place preference	2.0	2.6	3.6	-0.7	1.9	-1.7	-1.8
Time in novel zone, NPP test	1.6	1.9	2.8	-0.7	1.7	-1.4	-1.6
Total zone transitions, NPP test	1.0	1.5	3.4	-1.8	1.0	-1.1	-0.6
Total locomotion distance, NPP test	0.1	0.2	0.3	-0.2	-0.6	0.6	0.1
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.2	-0.4	0.3	-0.0
Intraocular pressure	0.9	1.5	1.9	1.4	1.0	-1.1	-1.3
Delta distance traveled before/after self-admin	1.3	1.4	2.4	0.5	-1.4	1.0	1.6
Delta ambulatory time before/after self-admin	0.8	1.3	2.3	0.3	-1.5	0.9	1.5
Parametrial fat weight	1.1	2.6	6.2	2.5	-1.1	1.4	-1.1
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.8	-0.7	0.2	0.2
Pavlov. Cond. magazine entry latency	0.6	0.8	1.1	-0.8	1.1	-0.6	-0.9
Pavlov. Cond. change in total contacts	1.4	1.5	2.5	-0.2	1.4	-1.2	-1.6
Pavlov. Cond. index score	0.6	0.7	1.2	-0.6	1.1	-0.8	-0.7
Pavlov. Cond. latency score	0.3	0.3	0.6	-0.6	0.8	-0.4	-0.5
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.6	0.3	0.1	-0.0
Pavlov. Cond. magazine entry number	1.0	1.3	2.1	0.6	-1.5	1.3	1.0
Pavlov. Cond. intertrial magazine entries	0.4	0.4	1.2	1.1	0.5	-0.3	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.5	-0.8	1.2	-0.9	-0.9
Pavlov. Cond. response bias	0.7	0.8	1.5	-0.6	1.2	-0.9	-0.8
Pavlov. Cond. lever latency	1.3	1.9	2.8	0.9	-1.7	1.3	1.5
Pavlov. Cond. magazine entry latency	3.0	4.2	6.5	-2.6	2.3	-2.0	-1.1
Pavlov. Cond. change in total contacts	2.2	5.4	8.1	-1.4	2.8	-2.5	-2.4
Pavlov. Cond. index score	3.0	4.8	6.9	-1.9	2.6	-2.2	-1.9
Pavlov. Cond. latency score	2.8	4.4	6.4	-1.7	2.5	-2.1	-1.9
Pavlov. Cond. lever contacts	1.3	1.9	2.7	-0.9	1.7	-1.4	-1.4
Pavlov. Cond. magazine entry number	6.1	8.0	10.7	3.1	-3.3	2.9	1.9
Pavlov. Cond. intertrial magazine entries	0.3	0.6	1.7	1.3	-0.7	0.4	0.4
Pavlov. Cond. lever-magazine prob. diff.	3.5	5.3	7.6	-2.1	2.8	-2.4	-1.9
Pavlov. Cond. response bias	2.6	3.5	4.8	-1.8	2.2	-1.9	-1.6
Time in closed arm before self-admin	0.5	0.8	2.1	0.5	0.6	-0.7	-1.4
Time in closed arm after self-admin	0.8	1.0	1.4	0.7	-1.2	1.2	0.7
Time in open arm before self-admin	4.9	6.0	11.0	0.3	-2.6	2.5	3.3
Time in open arm after self-admin	0.2	0.2	0.4	-0.5	-0.0	0.1	0.7
Bone: periosteal estimation	0.4	0.9	2.8	-0.2	0.8	-0.2	-1.7
Bone: periosteal perimeter	0.5	1.0	2.5	-0.5	0.9	-0.6	-1.6
Bone: post-yield work	1.7	3.0	7.4	-0.8	1.5	-1.2	-2.7
Progressive ratio test 1 active lever presses	0.1	0.2	0.5	0.6	-0.2	-0.1	-0.7
Progressive ratio test 1 breakpoint	0.1	0.3	0.7	0.5	-0.1	-0.2	-0.8
Progressive ratio test 1 inactive lever presses	0.2	0.4	1.3	0.1	0.6	-0.2	-1.1
Progressive ratio test 2 active lever presses	1.3	1.8	3.9	1.8	0.3	-0.1	-2.0
Progressive ratio test 2 breakpoint	1.4	1.8	3.8	1.8	0.3	-0.0	-2.0
Progressive ratio test 2 inactive lever presses	1.3	4.2	10.8	3.3	0.1	0.6	-2.4
Incentive Sensitization - Responses	0.5	1.4	3.7	0.0	1.3	-0.5	-1.9
Incentive Sensitization - Breakpoint	0.6	1.4	3.8	0.3	1.3	-0.4	-1.9
Sum of active levers in priming session hrs 5-6	5.6	5.2	8.4	-0.6	2.6	-2.9	-2.3
Progressive ratio	0.4	1.3	1.8	-1.3	1.0	-1.0	-1.2
Food seeking constrained by brief footshock	0.2	0.3	0.5	-0.3	-0.6	0.5	0.7
Seeking ratio, punishment vs. effort	1.6	3.6	4.6	1.3	-1.9	2.1	2.1
Retroperitoneal fat weight	4.2	18.9	37.3	6.1	-4.0	4.7	0.9
Reaction time number correct	0.0	0.2	0.3	-0.5	0.4	-0.4	-0.1
Reaction time mean minus median	0.8	5.2	8.4	-2.0	2.4	-2.9	-1.5
Reaction time mean minus median AUC	0.4	2.3	4.5	-1.4	1.5	-2.1	-0.7
Reaction time num false alarms	1.9	3.3	4.8	0.6	-2.0	1.9	2.2
Reaction time num false alarms AUC	1.0	2.2	4.4	-0.0	-1.5	1.5	2.1
Reaction time trials correct on left	0.0	0.2	0.3	-0.5	0.4	-0.4	-0.1
Reaction time trials on left	0.1	0.2	0.4	-0.6	0.5	-0.5	-0.1
Reaction time mean	0.3	0.7	1.5	-0.0	0.9	-1.2	-0.7
Reaction time mean AUC	0.3	0.7	1.5	0.0	0.9	-1.2	-0.8
Median of all reaction times	0.1	0.2	0.3	0.5	0.3	-0.5	-0.5
Reaction time omissions	0.7	1.1	2.3	-1.2	0.9	-1.5	-0.2
Reaction time false alarm rate	1.8	2.4	3.5	0.5	-1.7	1.7	1.9
Reaction time premature initiation rate	1.0	1.5	4.6	-2.1	0.0	0.7	1.0
Reaction time premature initiations	0.6	1.8	6.3	-2.5	0.5	0.1	0.8
Std. dev. reaction times	0.5	1.8	4.2	-0.8	1.3	-2.0	-0.8
Reaction time trials completed	0.1	0.2	0.4	-0.6	0.5	-0.5	-0.1
Reaction time trials AUC	0.0	0.1	0.2	-0.5	0.3	-0.2	0.1
Run reversals in cocaine runway, females	1.5	1.7	2.6	-0.9	-1.1	1.6	1.5
Run reversals in cocaine runway, males	0.2	0.2	0.4	0.4	-0.7	0.3	0.4
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.3	-0.2	0.3	-0.4
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	0.1	0.2	-0.0	-0.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.5	0.1	-0.7	0.3	-0.0
Std. dev. time between licks in bursts	1.2	2.3	4.1	-0.0	-1.5	1.6	2.0
Total sessions with >9 infusions	0.1	0.1	0.3	0.1	-0.5	0.1	-0.1
Short access day 1 total inactive lever presses	0.9	1.9	3.6	1.9	-1.1	1.7	0.2
Short access day 10 total inactive lever presses	0.1	0.9	1.0	1.0	-1.0	0.9	1.0
Short access day 1 total infusions	0.6	1.3	2.1	1.5	-1.3	1.2	0.1
Short access day 10 total infusions	0.3	0.5	1.1	0.6	-0.4	0.5	-1.0
Short access total infusions	0.5	0.7	1.3	0.6	-1.2	1.0	-0.1
Short access day 1 locomotion	0.4	0.6	1.6	1.3	-0.4	0.8	-0.3
Short access day 10 total locomotion	0.2	0.7	1.7	0.9	0.2	0.3	-1.3
Short access total locomotion	0.5	0.7	1.5	1.2	-0.1	0.6	-0.9
One hour access (0.3 mA shock)	2.2	2.6	7.3	2.7	-0.4	1.3	-1.1
Compulsive drug intake	1.2	1.8	4.5	-1.5	-0.3	0.5	2.1
One hour access (shock baseline)	1.3	3.5	9.6	3.1	-0.3	0.5	-2.1
Social response proportion	0.5	0.7	1.0	-0.8	0.7	-1.0	-0.7
Social responses	0.2	0.2	0.4	-0.6	0.4	-0.6	0.0
Social time	0.1	0.2	0.4	-0.6	0.1	-0.4	0.6
Soleus weight	2.5	7.3	13.8	3.7	-2.8	2.6	1.1
Bone: stiffness	2.3	4.2	4.4	-1.9	2.0	-2.1	-2.1
Tibialis anterior weight	5.8	19.9	38.2	-6.2	4.7	-4.2	-1.4
Time to tail flick, vehicle, before self-admin	0.5	0.6	1.6	-0.7	0.6	-0.3	-1.3
Time to tail flick, vehicle, after self-admin	0.4	0.8	2.6	-1.6	-0.1	0.2	0.6
Time to tail flick, test, before self-admin	1.5	1.7	4.3	0.9	-1.2	2.1	0.6
Time to tail flick, test, after self-admin	0.6	0.7	1.0	-0.4	0.9	-1.0	-0.9
Delta time to tail flick, vehicle, before/after SA	0.5	0.6	1.2	-1.0	-0.2	0.2	1.1
Delta time to tail flick, test, before/after SA	2.4	3.0	6.4	-0.9	1.9	-2.5	-1.2
Tibia length	2.9	7.9	11.5	-1.5	3.4	-3.0	-3.0
Ambulatory time before self-admin	0.9	2.8	4.2	-0.8	2.1	-1.7	-1.8
Ambulatory time after self-admin	0.3	0.4	0.8	0.5	0.6	-0.5	-0.9
Bone: tissue strength	0.0	0.1	0.1	0.2	0.2	-0.3	-0.2
Total heroin consumption	3.5	4.1	6.8	-2.6	2.1	-2.2	-0.6
Bone: trabecular number	1.1	2.1	2.6	-1.3	1.6	-1.2	-1.6
Bone: trabecular spacing	1.2	1.7	2.7	0.9	-1.4	1.2	1.7
Bone: trabecular thickness	0.1	0.1	0.5	0.7	-0.1	0.3	-0.1
Bone: trabecular tissue density	1.5	2.7	7.5	2.7	-1.6	0.7	0.2
Water consumed over 24 hours	0.3	0.6	1.2	-1.1	0.7	-0.7	0.1
Number of responses in last shaping day	0.3	0.4	0.9	0.0	-0.5	0.6	0.9