Hub : Genes

Stip1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	gene expression	Stip1	0.14	0.09	5.0e-03	0.07	0.03	0.01	0.03	7.2e-03	6.4e-02	1.6e-01	5.3e-02
2	Brain	mRNA stability	Stip1	0.07	0.04	2.6e-04	0.01	0.04	0.02	0.03	2.1e-02	2.6e-04	2.4e-03	5.6e-04
3	BLA	gene expression	Stip1	0.12	0.09	9.1e-03	0.04	0.01	0.04	0.03	5.5e-03	6.8e-02	2.3e-03	9.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.2	0.4	0.6	0.8	-0.6	0.4
Area under the delay curve	0.5	0.5	1.0	0.1	0.6	1.0
BMI with tail	1.5	4.7	9.9	3.1	-1.2	1.7
BMI without tail	0.9	1.9	4.0	2.0	-0.1	1.3
Body weight	1.7	7.3	18.1	4.3	-2.0	-0.1
Weight adjusted by age	1.9	2.1	3.0	1.7	-1.6	-0.8
Bone surface	3.3	5.8	8.6	2.9	-2.9	-0.8
Bone volume	1.7	2.9	5.5	1.6	-2.3	-0.7
Breakpoint value in progressive ratio session	2.8	3.0	3.6	1.9	-1.9	-1.4
Number of licking bursts	0.2	0.3	0.4	0.5	-0.6	-0.3
Context. condit. distance diff. score	1.3	1.5	1.9	-1.4	1.3	1.0
Locomotion velocity, session 1	0.7	0.7	1.3	0.0	1.0	1.1
Locomotion distance, session 1	0.6	0.7	1.7	0.5	0.5	1.3
Locomotion velocity, session 2	1.1	1.3	3.3	1.8	-0.8	-0.1
Locomotion distance, session 2	0.6	0.8	1.5	0.7	0.6	1.2
Locomotion velocity, session 3	1.3	1.6	3.1	-0.8	1.0	1.8
Locomotion distance, session 3	0.2	0.2	0.4	-0.2	0.4	0.6
Stereotopy head waving bouts, day 3	2.5	2.9	5.3	-1.1	1.5	2.3
Stereotopy head waving duration, day 3	1.0	1.1	1.3	-1.1	0.9	1.1
Locomotion velocity, session 7	1.1	1.2	2.0	-1.1	0.7	1.4
Locomotion distance, session 7	1.3	1.6	3.0	-0.5	1.3	1.7
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	-0.3	-0.7	-0.4
Stereotopy head waving duration, day 7	1.5	1.9	2.5	1.2	-1.6	-1.3
Locomotion velocity, session 8	0.6	0.8	1.1	1.0	0.6	0.9
Locomotion distance, session 8	0.9	1.3	2.9	-0.5	0.8	1.7
Degree of sensitization distance	0.7	0.7	1.6	-0.4	0.7	1.3
Degree of sensitization stereotypy	1.4	1.5	2.4	0.8	-1.5	-1.2
Conditioned locomotion	0.5	0.6	1.5	1.2	-0.4	0.1
Cocaine response after cond. corrected	2.3	2.6	3.7	-1.4	1.9	1.4
Cocaine response after cond. not corrected	1.7	1.9	2.7	-1.1	1.7	1.3
Cocaine response before conditioning	1.2	1.5	1.9	1.2	-1.4	-1.0
Saline control response	2.0	2.6	6.5	2.5	-1.0	-0.6
Bone: connectivity density	1.3	2.0	4.0	2.0	-1.4	0.1
Bone: cortical apparent density	0.2	0.3	0.5	0.5	-0.2	-0.7
Bone: cortical area	1.0	1.5	2.3	1.1	-1.5	-1.0
Bone: cortical porosity	0.0	0.0	0.0	0.2	-0.1	0.0
Bone: cortical porosity	0.2	0.2	0.6	0.8	-0.3	-0.2
Bone: cortical thickness	1.6	2.6	4.8	2.2	-1.0	-1.5
Bone: cortical thickness	0.3	0.4	0.5	0.7	0.7	0.5
Bone: cortical tissue density	0.2	0.3	0.6	0.6	-0.3	-0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.4	-0.2	-0.3
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	0.2	-0.2	-0.7
Condit. Reinf. active responses	0.1	0.1	0.1	0.1	-0.3	-0.3
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	-0.2	0.4
Incentive salience index mean	0.1	0.1	0.3	0.6	-0.2	0.1
Condit. Reinf. lever presses	0.2	0.3	0.4	0.7	-0.6	0.1
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	-0.5	-0.7	-0.4
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.0	-1.0	-0.9	-0.3
Condit. Reinf. active responses	0.1	0.2	0.4	0.1	-0.6	-0.4
Condit. Reinf. inactive responses	0.2	0.3	0.7	0.8	0.3	0.2
Condit. Reinf. lever presses	2.2	3.0	4.8	1.8	-2.2	-1.1
Condit. Reinf. lever reinforcers received	0.5	0.7	1.1	0.6	-1.1	-0.8
Conditioned reinforcement - actives	0.4	0.4	0.7	-0.6	-0.8	-0.2
Conditioned reinforcement - inactives	1.9	2.1	5.5	-2.3	-0.2	-0.9
Conditioned locomotion	3.7	4.4	12.2	-3.5	0.9	-0.4
Patch foraging indifference point 0 sec	0.2	0.3	0.8	-0.2	-0.3	-0.9
Patch foraging indifference point AUC	4.0	4.6	5.5	2.3	-2.4	-1.8
Delay disc. indifference point, 0s delay	2.5	2.7	5.6	-0.4	1.6	2.4
Delay disc. indifference point, 16s delay	0.3	0.3	0.9	-1.0	-0.1	-0.3
Delay disc. indifference point, 2s delay	0.5	0.5	1.4	-0.1	0.3	1.2
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	-0.0	0.7	-0.2
Delay disc. indifference point, 4s delay	1.2	1.3	2.2	0.0	1.3	1.5
Delay disc. indifference point, 8s delay	1.1	1.1	1.8	0.1	1.2	1.4
Indifference point function ln k	8.3	11.6	14.8	-3.6	3.9	2.7
Indifference point function log k	8.3	11.6	14.8	-3.6	3.9	2.7
Patch foraging total patch changes 0 sec	0.1	0.2	0.7	-0.2	-0.0	-0.8
Patch foraging total patch changes 12 sec	4.2	5.4	7.6	2.8	-2.2	-1.9
Patch foraging total patch changes 18 sec	1.1	1.5	1.9	1.1	-1.4	-1.1
Patch foraging total patch changes 24 sec	3.1	3.8	4.5	2.1	-1.9	-1.8
Patch foraging total patch changes 6 sec	0.4	0.5	1.3	1.1	-0.5	-0.3
Patch foraging time to switch 0 sec	1.0	1.5	2.1	1.4	-1.4	0.7
Patch foraging water rate 0 sec	1.8	2.8	6.0	-2.5	1.4	-0.6
Patch foraging water rate 12 sec	4.9	7.5	11.6	-3.4	3.3	0.4
Patch foraging water rate 18 sec	3.2	4.3	6.2	-2.1	2.5	1.4
Patch foraging water rate 24 sec	2.1	3.0	4.5	-2.0	2.1	0.7
Patch foraging water rate 6 sec	3.3	4.8	7.5	-2.5	2.7	0.8
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.4	0.4	-0.1
Distance traveled before self-admin	1.7	1.8	2.5	0.8	-1.6	-1.5
Distance traveled after self-admin	1.1	1.2	2.4	0.5	-1.0	-1.5
Extensor digitorum longus weight	3.8	14.9	31.9	5.6	-3.3	-1.4
Bone: elastic displacement	1.6	1.8	3.4	-1.3	1.9	0.6
Bone: elastic work	0.4	0.5	0.8	0.9	0.7	0.3
Bone: endosteal estimation	0.9	2.0	4.3	-1.3	0.3	2.1
Bone: endosteal perimeter	0.7	1.5	2.2	-1.4	-0.3	1.5
Epididymis fat weight	1.0	2.4	5.9	-2.4	0.9	0.6
Delta time in closed arm before/after self-admin	1.3	1.3	2.9	-0.3	1.7	0.9
Delta time in open arm before/after self-admin	2.3	2.2	3.7	0.6	-1.9	-1.6
Diff in mean of infusions in LGA sessions	0.8	0.9	1.6	0.6	-0.8	-1.3
Delay discount exponential model param	0.4	0.4	0.8	-0.2	-0.6	-0.9
Extinction: sum of active levers before priming	3.0	3.0	5.1	2.3	-1.7	-1.0
Active lever presses in extinction session 6	3.8	3.7	5.0	1.7	-2.2	-1.8
Bone: final force	1.7	2.8	5.2	2.3	-1.8	-0.4
Bone: final moment	1.6	2.6	4.6	2.1	-1.7	-0.5
Food consumed during 24 hour testing period	0.9	1.1	1.9	0.3	-1.1	-1.4
Glucose	1.8	2.7	3.4	-1.8	1.2	1.8
Heart weight	2.9	4.2	5.6	-2.4	2.1	1.5
Delay discount hyperbolic model param	0.5	0.5	1.1	-0.2	-0.6	-1.0
Intermittent access intake day 1-15 change	1.2	1.1	2.4	-0.6	-0.8	-1.6
Intermittent access intake escalation	1.0	1.0	2.0	-0.6	-0.7	-1.4
Intermittent access intake escalation 2	2.0	2.0	4.4	-0.2	-1.2	-2.1
Intermitt. access day 1 inactive lever presses	1.0	1.0	2.8	-1.7	0.5	0.3
Intermitt. access day 15 inactive lever presses	1.5	1.7	4.1	-2.0	-0.5	-0.8
Intermitt. access escalation Index	2.7	2.4	3.3	-1.5	1.8	1.2
Intermittent access day 1 total infusions	3.4	4.0	6.5	-2.5	1.2	2.0
Intermittent access day 15 total infusions	2.7	3.1	8.8	-3.0	0.5	0.3
Intermittent access terminal intake (last 3 days)	1.5	1.7	4.9	-2.2	-0.1	-0.0
Intermittent access total infusions	1.9	2.1	5.5	-2.3	0.3	0.8
Intermittent access day 1 locomotion	3.5	3.7	4.7	-2.0	1.6	2.2
Intermittent access day 15 total locomotion	1.6	1.7	5.0	-2.2	0.1	-0.0
Intermittent access total locomotion	2.3	2.6	7.3	-2.7	0.3	0.7
Intermittent access standard deviation	0.7	0.7	1.2	-1.1	-0.2	-1.0
Left kidney weight	0.2	0.4	1.2	-1.1	-0.0	-0.3
Right kidney weight	0.3	0.8	1.3	-0.5	-1.2	-0.8
Cocaine induced anxiety	0.4	0.5	0.7	0.3	-0.8	-0.8
Post-drug Anxiety	1.6	1.8	2.6	1.1	-1.6	-1.2
Baseline Anxiety	0.8	0.9	2.1	1.5	-0.5	-0.5
Tail length	0.4	1.3	2.8	1.7	-0.3	-1.0
Length with tail	1.1	4.1	8.2	2.9	-1.5	-1.4
Length without tail	0.9	2.0	3.6	1.9	-1.3	-0.8
Times rat made contact with spout	0.2	0.2	0.7	0.8	0.1	-0.2
Lifetime Intake	2.2	2.4	5.0	-2.2	0.8	1.3
Liver weight, left	0.2	0.4	0.7	-0.4	0.5	0.8
Liver weight, right	0.9	1.4	3.0	-0.2	1.1	1.7
Locomotor activity	1.7	2.7	5.0	-1.7	2.2	0.6
Locomotor testing distance	3.0	4.9	9.2	-2.0	3.0	1.3
Locomotor testing rearing	2.2	3.3	5.7	-1.8	2.4	1.0
Locomotion in novel chamber	1.4	1.8	5.2	-2.3	0.0	0.2
Locomotion in novel chamber post-restriction	1.7	2.0	4.9	-2.2	0.9	0.6
Fecal boli incidents, locomotor time 1	1.0	1.1	2.5	0.3	-1.6	-0.8
Change in fecal boli incidents, locomotor task	3.6	3.4	6.1	-0.1	2.0	2.5
Time >=10cm from walls, locomotor time 1	0.5	0.5	0.8	-0.7	-0.5	0.9
Bouts of movement, locomotor time 1	3.0	3.3	5.9	1.2	-1.6	-2.4
Total resting periods, locomotor time 1	2.8	3.1	5.5	1.0	-1.6	-2.3
Rest time, locomotor task time 1	0.5	0.6	1.5	-1.2	0.5	0.0
Distance moved, locomotor task time 1	0.1	0.1	0.2	0.5	0.0	0.2
Vertical activity count, locomotor time 1	0.8	0.9	1.5	-1.2	1.0	0.5
Time >=10cm from walls, locomotor time 2	0.8	0.8	1.5	0.2	-1.2	-1.0
Bouts of movement, locomotor time 2	1.0	1.1	2.2	0.7	-0.8	-1.5
Total resting periods, locomotor time 2	0.7	0.7	1.6	0.5	-0.6	-1.3
Rest time, locomotor task time 2	2.0	2.3	3.5	-1.9	1.3	1.3
Distance moved, locomotor task time 2	1.1	1.3	1.9	1.4	-0.9	-1.1
Vertical activity count, locomotor time 2	0.2	0.2	0.6	-0.1	0.8	-0.3
Light reinforcement 1	0.2	0.3	0.7	-0.4	0.0	-0.8
Light reinforcement 2	1.1	1.5	1.9	-1.4	-1.2	-1.1
Bone: marrow area	1.1	2.3	4.9	-1.3	0.5	2.2
Bone: maximum diameter	0.8	1.5	3.3	0.6	-1.8	-0.9
Bone: maximum force	2.1	3.7	5.7	2.4	-2.3	-0.2
Bone: maximum moment	1.8	3.1	4.8	2.2	-2.1	-0.3
Mean time between licks in bursts	0.5	0.7	1.3	0.7	1.1	0.7
Mean num. licks in bursts	0.2	0.3	0.6	-0.4	0.8	0.1
Cd content in liver	0.3	0.3	0.4	-0.6	-0.5	-0.5
Co content in liver	1.5	1.8	3.5	-1.3	1.9	0.4
Cu content in liver	0.3	0.3	0.5	0.5	-0.5	-0.7
Fe content in liver	0.2	0.3	0.7	0.4	-0.8	0.0
K content in liver	0.7	0.6	1.1	1.1	-0.4	0.8
Mg content in liver	0.2	0.2	0.6	-0.1	0.0	0.8
Mn content in liver	2.7	3.0	4.9	1.5	-2.2	-1.4
Na content in liver	0.7	0.7	1.2	0.9	-1.1	-0.4
Rb content in liver	1.8	2.2	2.6	-1.6	1.4	1.5
Se content in liver	1.8	2.2	4.1	0.2	-2.0	-1.5
Sr content in liver	4.4	4.0	5.2	1.8	-1.9	-2.3
Zn content in liver	1.4	1.6	1.9	1.0	-1.3	-1.4
Bone: minimum diameter	0.5	1.0	1.7	-1.1	0.1	1.3
Time in familiar zone, hab. session 1	0.2	0.2	0.3	-0.5	0.3	0.6
Time in novel zone, hab. session 1	0.7	0.7	1.4	-0.4	1.2	0.7
Total zone transitions, hab. session 1	0.2	0.3	0.7	0.8	-0.5	-0.2
Total locomotion distance, hab. session 1	0.6	0.8	1.4	-0.8	0.5	1.2
Locomotion velocity, hab. session 1	0.1	0.2	0.5	-0.3	0.2	0.7
Time in familiar zone, hab. session 2	1.0	1.1	1.9	0.1	1.4	1.1
Time in novel zone, hab. session 2	0.5	0.5	0.8	0.1	-0.9	-0.8
Total zone transitions, hab. session 2	0.6	0.8	1.2	1.1	-0.1	1.0
Total locomotion distance, hab. session 2	1.0	1.4	3.3	-0.2	0.8	1.8
Locomotion velocity, hab. session 2	1.0	1.3	3.3	-0.4	0.7	1.8
Novel to familiar place preference ratio	3.1	3.2	5.1	1.3	-2.3	-1.6
Novelty place preference	2.3	2.4	3.8	1.0	-1.9	-1.5
Time in novel zone, NPP test	1.7	1.8	2.8	0.8	-1.7	-1.4
Total zone transitions, NPP test	1.0	1.4	3.4	1.8	-0.9	0.1
Total locomotion distance, NPP test	0.5	0.7	1.7	-0.1	0.6	1.3
Locomotion velocity, NPP test	0.3	0.4	1.1	0.0	0.3	1.0
Intraocular pressure	1.4	2.0	4.1	-0.7	-1.2	-2.0
Delta distance traveled before/after self-admin	0.4	0.4	0.8	-0.1	0.9	0.6
Delta ambulatory time before/after self-admin	0.6	0.7	1.4	-0.0	1.2	0.8
Parametrial fat weight	1.5	2.9	4.4	-1.7	1.1	2.1
Pavlov. Cond. lever latency	0.2	0.3	0.5	-0.7	0.6	0.2
Pavlov. Cond. magazine entry latency	0.3	0.4	0.7	0.6	-0.9	-0.3
Pavlov. Cond. change in total contacts	0.9	1.0	1.9	0.3	-1.4	-0.9
Pavlov. Cond. index score	0.5	0.6	0.9	0.6	-0.9	-0.8
Pavlov. Cond. latency score	0.2	0.2	0.3	0.5	-0.6	-0.4
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.2	-0.0	0.2
Pavlov. Cond. magazine entry number	1.3	1.6	2.2	-0.8	1.4	1.5
Pavlov. Cond. intertrial magazine entries	0.8	0.9	2.0	-0.8	-0.4	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.2	0.9	-1.1	-0.8
Pavlov. Cond. response bias	0.6	0.7	1.0	0.5	-1.0	-1.0
Pavlov. Cond. lever latency	0.9	1.2	2.1	-1.0	1.4	0.8
Pavlov. Cond. magazine entry latency	2.9	3.4	5.4	2.3	-1.8	-1.2
Pavlov. Cond. change in total contacts	3.8	5.2	8.4	1.6	-2.9	-2.2
Pavlov. Cond. index score	3.2	4.1	5.7	2.0	-2.4	-1.6
Pavlov. Cond. latency score	2.7	3.4	4.8	1.8	-2.2	-1.4
Pavlov. Cond. lever contacts	1.1	1.6	2.3	1.0	-1.5	-1.2
Pavlov. Cond. magazine entry number	5.9	7.2	9.1	-3.0	2.9	2.1
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.2	-1.1	0.7	0.4
Pavlov. Cond. lever-magazine prob. diff.	3.5	4.5	5.9	2.2	-2.4	-1.7
Pavlov. Cond. response bias	2.4	3.3	4.4	1.8	-2.1	-1.5
Time in closed arm before self-admin	0.4	0.5	1.1	0.5	-1.0	-0.2
Time in closed arm after self-admin	1.0	1.1	1.7	-0.5	1.1	1.3
Time in open arm before self-admin	2.8	3.0	6.5	-0.9	2.5	1.4
Time in open arm after self-admin	0.2	0.3	0.8	-0.0	0.1	-0.9
Bone: periosteal estimation	0.2	0.4	0.9	-0.1	-1.0	0.5
Bone: periosteal perimeter	0.3	0.5	1.3	0.3	-1.1	0.0
Bone: post-yield work	1.1	1.5	3.1	0.3	-1.8	1.1
Progressive ratio test 1 active lever presses	1.4	1.5	3.4	-1.8	0.7	0.7
Progressive ratio test 1 breakpoint	1.1	1.2	2.6	-1.6	0.6	0.7
Progressive ratio test 1 inactive lever presses	0.6	0.6	1.0	-1.0	0.8	0.4
Progressive ratio test 2 active lever presses	1.8	1.9	5.6	-2.4	0.2	0.4
Progressive ratio test 2 breakpoint	2.3	2.6	7.4	-2.7	0.4	0.3
Progressive ratio test 2 inactive lever presses	2.7	3.1	9.2	-3.0	0.3	-0.2
Incentive Sensitization - Responses	0.4	0.4	0.7	-0.8	-0.7	-0.4
Incentive Sensitization - Breakpoint	0.5	0.5	1.1	-1.1	-0.6	-0.4
Sum of active levers in priming session hrs 5-6	5.9	5.7	8.2	1.2	-2.9	-2.7
Progressive ratio	1.0	1.2	2.2	1.5	-1.1	0.1
Food seeking constrained by brief footshock	0.5	0.7	1.1	0.3	0.9	1.0
Seeking ratio, punishment vs. effort	1.9	2.3	4.0	-1.4	2.0	0.9
Retroperitoneal fat weight	2.9	9.7	19.5	-4.4	2.3	2.0
Reaction time number correct	0.3	0.4	0.7	0.6	-0.3	-0.8
Reaction time mean minus median	3.1	4.1	5.8	2.2	-2.4	-1.2
Reaction time mean minus median AUC	1.7	2.3	3.1	1.8	-1.6	-1.0
Reaction time num false alarms	1.5	2.1	4.4	-0.8	2.1	1.1
Reaction time num false alarms AUC	0.8	1.1	2.7	-0.1	1.6	0.7
Reaction time trials correct on left	0.3	0.4	0.7	0.6	-0.3	-0.8
Reaction time trials on left	0.3	0.5	0.8	0.7	-0.4	-0.9
Reaction time mean	0.5	0.6	1.1	0.3	-1.0	-0.9
Reaction time mean AUC	0.5	0.6	1.1	0.2	-1.1	-0.8
Median of all reaction times	0.2	0.3	0.4	-0.2	-0.6	-0.7
Reaction time omissions	0.5	0.7	1.6	1.3	-0.7	-0.5
Reaction time false alarm rate	1.3	1.8	3.2	-0.7	1.8	1.3
Reaction time premature initiation rate	0.8	1.1	3.1	1.8	0.3	0.4
Reaction time premature initiations	1.3	1.9	5.4	2.3	-0.1	-0.4
Std. dev. reaction times	1.0	1.4	2.3	1.0	-1.5	-1.0
Reaction time trials completed	0.3	0.5	0.8	0.7	-0.4	-0.9
Reaction time trials AUC	0.2	0.2	0.4	0.5	-0.1	-0.6
Run reversals in cocaine runway, females	2.0	1.9	3.8	0.5	1.3	2.0
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.1	0.6	0.4
Latency to leave start box in cocaine runway	0.3	0.3	0.6	-0.5	0.1	0.8
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	-0.2	-0.4	-0.3
Latency to leave start box in cocaine runway, M	1.1	1.0	2.5	-0.4	0.6	1.6
Std. dev. time between licks in bursts	1.2	1.5	3.1	-0.4	1.8	1.1
Total sessions with >9 infusions	2.8	3.1	4.4	-1.5	1.6	2.1
Short access day 1 total inactive lever presses	2.6	2.9	5.5	-2.4	1.5	0.9
Short access day 10 total inactive lever presses	3.3	3.7	4.9	-2.2	2.2	1.2
Short access day 1 total infusions	2.6	2.8	3.6	-1.9	1.4	1.7
Short access day 10 total infusions	2.2	2.5	4.1	-1.6	0.9	2.0
Short access total infusions	2.4	2.7	4.3	-1.4	1.3	2.1
Short access day 1 locomotion	1.8	1.9	2.3	-1.5	1.2	1.4
Short access day 10 total locomotion	1.0	1.2	2.1	-1.4	0.8	0.9
Short access total locomotion	1.4	1.4	1.7	-1.3	1.0	1.3
One hour access (0.3 mA shock)	3.9	4.5	12.1	-3.5	1.1	0.6
Compulsive drug intake	0.9	0.9	2.4	1.5	0.5	0.2
One hour access (shock baseline)	2.9	3.4	10.2	-3.2	-0.0	-0.2
Social response proportion	0.7	0.7	1.2	1.1	-0.9	-0.4
Social responses	0.3	0.4	0.7	0.8	-0.3	-0.6
Social time	0.2	0.3	0.9	0.9	0.0	-0.1
Soleus weight	2.6	7.7	14.4	-3.8	2.6	1.5
Bone: stiffness	2.0	3.1	4.9	2.1	-2.2	-0.4
Tibialis anterior weight	6.8	23.3	42.1	6.5	-4.3	-3.0
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.7	0.8	-0.7	0.5
Time to tail flick, vehicle, after self-admin	1.6	1.7	3.2	1.8	0.3	1.3
Time to tail flick, test, before self-admin	1.3	1.3	1.8	-0.7	1.3	1.3
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.4	-0.0	-0.3
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.8	0.9	0.5	0.6
Delta time to tail flick, test, before/after SA	2.5	2.2	3.5	1.1	-1.4	-1.9
Tibia length	2.6	7.3	12.2	1.9	-3.5	-2.5
Ambulatory time before self-admin	1.8	1.9	3.9	0.7	-2.0	-1.2
Ambulatory time after self-admin	0.8	0.8	1.6	-0.2	-0.9	-1.3
Bone: tissue strength	0.2	0.2	0.3	-0.0	-0.6	-0.5
Total heroin consumption	3.5	4.2	7.9	2.8	-1.8	-1.2
Bone: trabecular number	0.7	1.1	2.3	0.9	-1.5	-0.5
Bone: trabecular spacing	0.7	0.9	1.8	-0.7	1.4	0.6
Bone: trabecular thickness	0.2	0.3	0.8	-0.9	0.1	0.0
Bone: trabecular tissue density	1.7	2.4	5.5	-2.3	1.2	0.5
Water consumed over 24 hours	0.8	1.0	1.4	1.1	-0.6	-1.2
Number of responses in last shaping day	0.7	0.7	1.2	-1.0	1.1	-0.3