Hub : Genes

Tmem258

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	LHb	mRNA stability	Tmem258	0.15	0.11	5.4e-03	0.01	0.02	-0	-0.01	1.6e-01	1.2e-01	3.5e-01	8.6e-01
2	Adipose	mRNA stability	Tmem258	0.04	0.03	7.8e-05	0.02	0.03	0.02	0.02	2.9e-03	4.6e-04	2.1e-03	2.6e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.0	0.0	0.0	-0.1	0.1
Area under the delay curve	0.1	0.1	0.1	-0.3	0.3
BMI with tail	0.2	0.7	0.9	0.7	-1.0
BMI without tail	0.1	0.5	0.6	0.6	-0.8
Body weight	1.0	4.2	4.7	1.9	-2.2
Weight adjusted by age	0.6	1.6	1.7	1.3	-1.3
Bone surface	0.2	0.3	0.3	0.5	-0.6
Bone volume	0.0	0.0	0.0	-0.1	0.0
Breakpoint value in progressive ratio session	2.9	5.2	5.2	2.3	-2.3
Number of licking bursts	0.0	0.0	0.0	-0.2	0.1
Context. condit. distance diff. score	0.1	0.1	0.1	-0.3	0.3
Locomotion velocity, session 1	0.1	0.1	0.1	0.4	-0.3
Locomotion distance, session 1	0.6	0.8	0.8	0.9	-0.9
Locomotion velocity, session 2	1.7	2.0	2.1	1.4	-1.4
Locomotion distance, session 2	0.7	1.0	1.0	1.0	-1.0
Locomotion velocity, session 3	0.2	0.2	0.3	-0.6	0.4
Locomotion distance, session 3	0.1	0.1	0.1	-0.3	0.3
Stereotopy head waving bouts, day 3	0.4	0.5	0.6	-0.8	0.7
Stereotopy head waving duration, day 3	0.1	0.1	0.1	-0.3	0.2
Locomotion velocity, session 7	0.1	0.1	0.1	-0.4	0.3
Locomotion distance, session 7	0.1	0.1	0.2	-0.4	0.3
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	0.2	-0.2
Stereotopy head waving duration, day 7	0.8	1.0	1.0	1.0	-1.0
Locomotion velocity, session 8	0.2	0.2	0.2	0.5	-0.5
Locomotion distance, session 8	0.1	0.2	0.2	-0.4	0.4
Degree of sensitization distance	0.1	0.1	0.1	-0.4	0.3
Degree of sensitization stereotypy	0.6	0.6	0.6	0.8	-0.8
Conditioned locomotion	0.4	0.5	0.5	0.7	-0.7
Cocaine response after cond. corrected	0.1	0.1	0.1	-0.4	0.4
Cocaine response after cond. not corrected	0.2	0.2	0.2	-0.4	0.5
Cocaine response before conditioning	0.1	0.1	0.1	0.3	-0.2
Saline control response	2.8	3.9	3.9	2.0	-2.0
Bone: connectivity density	0.3	0.5	0.5	0.7	-0.7
Bone: cortical apparent density	0.6	1.0	1.0	1.0	-1.0
Bone: cortical area	0.1	0.2	0.2	0.5	-0.4
Bone: cortical porosity	0.7	0.7	0.7	0.8	-0.9
Bone: cortical porosity	0.9	1.0	1.0	1.0	-1.0
Bone: cortical thickness	4.4	7.3	7.5	2.7	-2.7
Bone: cortical thickness	0.6	0.7	0.7	0.8	-0.8
Bone: cortical tissue density	0.9	1.4	1.4	1.2	-1.2
Condit. Reinf. active minus inactive responses	1.1	1.2	1.3	1.1	-1.1
Condit. Reinf. active-inactive response ratio	1.6	1.7	1.8	1.4	-1.3
Condit. Reinf. active responses	0.4	0.5	0.5	0.7	-0.7
Condit. Reinf. inactive responses	0.5	0.6	0.7	-0.8	0.8
Incentive salience index mean	0.3	0.4	0.5	0.7	-0.7
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.1	0.0
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.1	0.2
Condit. Reinf. active-inactive response ratio	0.4	0.7	0.7	-0.9	0.8
Condit. Reinf. active responses	0.0	0.1	0.1	0.3	-0.2
Condit. Reinf. inactive responses	0.1	0.2	0.3	0.5	-0.4
Condit. Reinf. lever presses	0.1	0.1	0.1	0.3	-0.3
Condit. Reinf. lever reinforcers received	0.2	0.3	0.4	0.6	-0.5
Conditioned reinforcement - actives	0.0	0.0	0.0	-0.1	0.2
Conditioned reinforcement - inactives	0.2	0.5	0.5	-0.7	0.7
Conditioned locomotion	2.8	4.2	4.3	-2.1	2.0
Patch foraging indifference point 0 sec	0.2	0.5	0.5	0.7	-0.7
Patch foraging indifference point AUC	0.8	1.8	1.9	1.4	-1.3
Delay disc. indifference point, 0s delay	1.0	1.2	1.3	-1.1	1.0
Delay disc. indifference point, 16s delay	0.0	0.0	0.0	-0.1	0.1
Delay disc. indifference point, 2s delay	1.6	1.8	1.8	-1.3	1.3
Delay disc. indifference point, 24s delay	0.0	0.0	0.0	-0.1	0.1
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	-0.2	0.1
Delay disc. indifference point, 8s delay	0.2	0.3	0.3	-0.5	0.5
Indifference point function ln k	2.0	6.0	6.3	-2.5	2.4
Indifference point function log k	2.0	6.0	6.3	-2.5	2.4
Patch foraging total patch changes 0 sec	0.3	0.8	0.8	0.9	-0.9
Patch foraging total patch changes 12 sec	7.3	9.7	9.8	3.1	-3.1
Patch foraging total patch changes 18 sec	0.6	1.3	1.4	1.2	-1.1
Patch foraging total patch changes 24 sec	1.5	5.3	5.5	2.2	-2.3
Patch foraging total patch changes 6 sec	0.4	0.7	0.8	0.8	-0.9
Patch foraging time to switch 0 sec	0.0	0.0	0.0	-0.1	0.1
Patch foraging water rate 0 sec	0.1	0.2	0.2	-0.4	0.5
Patch foraging water rate 12 sec	0.4	1.8	1.8	-1.3	1.3
Patch foraging water rate 18 sec	0.4	0.8	0.9	-0.9	0.9
Patch foraging water rate 24 sec	0.7	1.0	1.0	-1.0	1.0
Patch foraging water rate 6 sec	0.5	0.7	0.7	-0.8	0.8
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.1	-0.4	0.3
Distance traveled before self-admin	0.3	0.7	0.7	0.8	-0.8
Distance traveled after self-admin	0.4	0.7	0.7	0.8	-0.8
Extensor digitorum longus weight	3.8	15.3	16.1	3.8	-4.0
Bone: elastic displacement	0.1	0.1	0.2	0.4	-0.3
Bone: elastic work	1.8	2.4	2.4	1.6	-1.5
Bone: endosteal estimation	3.3	8.0	8.4	-2.9	2.8
Bone: endosteal perimeter	4.7	11.6	12.0	-3.5	3.3
Epididymis fat weight	1.6	8.0	8.2	-2.9	2.8
Delta time in closed arm before/after self-admin	2.7	2.5	2.7	1.5	-1.6
Delta time in open arm before/after self-admin	1.2	1.4	1.4	1.2	-1.2
Diff in mean of infusions in LGA sessions	2.3	4.2	4.2	2.0	-2.1
Delay discount exponential model param	0.1	0.1	0.1	0.4	-0.3
Extinction: sum of active levers before priming	1.6	2.5	2.6	1.5	-1.6
Active lever presses in extinction session 6	2.1	2.2	2.2	1.5	-1.5
Bone: final force	0.3	0.6	0.6	0.7	-0.8
Bone: final moment	0.4	0.7	0.7	0.8	-0.8
Food consumed during 24 hour testing period	0.0	0.1	0.1	-0.3	0.3
Glucose	4.3	6.8	6.8	-2.6	2.6
Heart weight	1.4	2.2	2.4	-1.6	1.4
Delay discount hyperbolic model param	0.2	0.3	0.3	0.5	-0.5
Intermittent access intake day 1-15 change	0.3	1.6	1.7	-1.2	1.3
Intermittent access intake escalation	0.3	1.9	2.0	-1.3	1.4
Intermittent access intake escalation 2	0.3	0.5	0.6	-0.7	0.8
Intermitt. access day 1 inactive lever presses	0.0	0.5	0.5	-0.7	0.7
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.3	-0.6	0.5
Intermitt. access escalation Index	0.3	0.8	0.8	-0.9	0.9
Intermittent access day 1 total infusions	1.5	4.4	4.7	-2.2	2.0
Intermittent access day 15 total infusions	3.6	8.8	8.8	-3.0	3.0
Intermittent access terminal intake (last 3 days)	2.8	4.9	5.0	-2.2	2.2
Intermittent access total infusions	4.5	5.3	5.5	-2.3	2.3
Intermittent access day 1 locomotion	0.8	1.4	1.6	-1.3	1.1
Intermittent access day 15 total locomotion	0.5	2.1	2.2	-1.5	1.4
Intermittent access total locomotion	4.2	5.1	5.3	-2.3	2.2
Intermittent access standard deviation	0.1	0.3	0.3	-0.5	0.5
Left kidney weight	0.5	4.2	4.4	-2.1	2.0
Right kidney weight	0.3	2.1	2.2	-1.5	1.4
Cocaine induced anxiety	0.1	0.3	0.3	0.5	-0.5
Post-drug Anxiety	0.1	0.1	0.1	0.3	-0.3
Baseline Anxiety	0.0	0.0	0.0	0.0	-0.1
Tail length	0.5	2.5	2.6	1.6	-1.6
Length with tail	0.9	4.2	4.4	2.0	-2.1
Length without tail	1.1	5.5	5.7	2.3	-2.4
Times rat made contact with spout	0.9	1.0	1.0	1.0	-1.0
Lifetime Intake	2.9	3.6	3.8	-1.9	1.9
Liver weight, left	0.5	0.8	0.9	-0.9	0.9
Liver weight, right	1.8	3.1	3.3	-1.7	1.8
Locomotor activity	0.1	0.1	0.1	-0.3	0.4
Locomotor testing distance	0.1	0.3	0.4	-0.5	0.6
Locomotor testing rearing	0.1	0.4	0.5	-0.6	0.7
Locomotion in novel chamber	2.4	3.3	3.3	-1.8	1.8
Locomotion in novel chamber post-restriction	0.3	0.8	0.9	-0.9	0.9
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.3	0.4
Change in fecal boli incidents, locomotor task	1.9	2.1	2.2	-1.5	1.4
Time >=10cm from walls, locomotor time 1	2.7	3.3	3.3	-1.8	1.8
Bouts of movement, locomotor time 1	2.9	3.8	4.0	2.0	-1.9
Total resting periods, locomotor time 1	2.1	2.4	2.6	1.6	-1.5
Rest time, locomotor task time 1	0.7	1.2	1.2	-1.1	1.1
Distance moved, locomotor task time 1	0.0	0.0	0.0	0.1	-0.2
Vertical activity count, locomotor time 1	0.1	0.5	0.5	-0.7	0.7
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.1	-0.2	0.3
Bouts of movement, locomotor time 2	0.9	3.1	3.1	1.7	-1.8
Total resting periods, locomotor time 2	0.5	2.0	2.1	1.4	-1.4
Rest time, locomotor task time 2	1.1	1.8	1.8	-1.3	1.3
Distance moved, locomotor task time 2	0.5	0.7	0.7	0.8	-0.8
Vertical activity count, locomotor time 2	0.1	0.2	0.2	0.5	-0.4
Light reinforcement 1	0.0	0.1	0.1	-0.2	0.3
Light reinforcement 2	0.9	2.0	2.1	-1.4	1.4
Bone: marrow area	3.6	8.7	9.2	-3.0	2.9
Bone: maximum diameter	0.2	0.4	0.4	-0.6	0.6
Bone: maximum force	0.2	0.3	0.4	0.5	-0.6
Bone: maximum moment	0.2	0.4	0.5	0.6	-0.7
Mean time between licks in bursts	0.1	0.7	0.7	0.8	-0.8
Mean num. licks in bursts	0.2	0.5	0.5	0.7	-0.6
Cd content in liver	0.7	0.8	0.8	-0.8	0.9
Co content in liver	0.0	0.0	0.0	-0.0	0.1
Cu content in liver	0.0	0.0	0.0	0.2	-0.2
Fe content in liver	0.0	0.0	0.0	-0.1	0.1
K content in liver	0.0	0.0	0.0	-0.1	0.0
Mg content in liver	0.2	0.2	0.2	-0.4	0.4
Mn content in liver	1.7	1.9	1.9	1.3	-1.4
Na content in liver	0.1	0.1	0.1	0.3	-0.2
Rb content in liver	1.9	2.3	2.3	-1.5	1.5
Se content in liver	0.0	0.0	0.0	-0.0	-0.0
Sr content in liver	5.6	4.8	4.9	2.2	-2.2
Zn content in liver	2.5	3.0	3.0	1.7	-1.7
Bone: minimum diameter	2.7	5.2	5.4	-2.3	2.3
Time in familiar zone, hab. session 1	0.0	0.0	0.0	-0.1	0.1
Time in novel zone, hab. session 1	0.7	0.8	0.8	-0.8	0.9
Total zone transitions, hab. session 1	0.6	0.9	0.9	1.0	-0.9
Total locomotion distance, hab. session 1	0.1	0.1	0.1	-0.3	0.3
Locomotion velocity, hab. session 1	0.1	0.2	0.2	0.4	-0.4
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.3	0.4
Time in novel zone, hab. session 2	0.2	0.2	0.2	0.4	-0.4
Total zone transitions, hab. session 2	0.8	1.0	1.1	1.0	-1.0
Total locomotion distance, hab. session 2	0.0	0.0	0.0	0.2	-0.1
Locomotion velocity, hab. session 2	0.0	0.0	0.0	-0.1	0.1
Novel to familiar place preference ratio	0.9	1.1	1.3	1.0	-1.1
Novelty place preference	0.4	0.6	0.7	0.7	-0.8
Time in novel zone, NPP test	0.6	0.7	0.9	0.8	-0.9
Total zone transitions, NPP test	1.8	2.6	2.7	1.7	-1.6
Total locomotion distance, NPP test	0.2	0.2	0.3	0.5	-0.5
Locomotion velocity, NPP test	0.1	0.2	0.2	0.5	-0.4
Intraocular pressure	0.0	0.1	0.1	0.3	-0.2
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.1	-0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	0.0	-0.0
Parametrial fat weight	5.3	12.4	12.9	-3.6	3.5
Pavlov. Cond. lever latency	0.1	0.2	0.2	-0.4	0.4
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.3	-0.3
Pavlov. Cond. change in total contacts	0.0	0.1	0.1	0.2	-0.2
Pavlov. Cond. index score	0.2	0.2	0.2	0.5	-0.5
Pavlov. Cond. latency score	0.1	0.1	0.1	0.3	-0.2
Pavlov. Cond. lever contacts	0.0	0.0	0.0	0.0	-0.0
Pavlov. Cond. magazine entry number	0.5	0.6	0.7	-0.8	0.8
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.5	0.7	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.3	0.6	-0.5
Pavlov. Cond. response bias	0.3	0.4	0.4	0.7	-0.6
Pavlov. Cond. lever latency	0.0	0.1	0.1	-0.3	0.3
Pavlov. Cond. magazine entry latency	3.5	4.9	5.1	2.2	-2.2
Pavlov. Cond. change in total contacts	0.2	0.6	0.6	0.8	-0.8
Pavlov. Cond. index score	1.0	1.6	1.6	1.2	-1.3
Pavlov. Cond. latency score	0.8	1.3	1.3	1.1	-1.2
Pavlov. Cond. lever contacts	0.1	0.1	0.1	0.4	-0.4
Pavlov. Cond. magazine entry number	5.7	7.5	7.7	-2.7	2.8
Pavlov. Cond. intertrial magazine entries	0.5	1.2	1.3	-1.0	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.3	2.0	2.1	1.4	-1.4
Pavlov. Cond. response bias	0.8	1.2	1.2	1.1	-1.1
Time in closed arm before self-admin	0.4	0.7	0.8	-0.8	0.9
Time in closed arm after self-admin	0.5	0.6	0.6	-0.7	0.7
Time in open arm before self-admin	0.1	0.1	0.1	-0.3	0.3
Time in open arm after self-admin	1.1	1.2	1.2	1.1	-1.1
Bone: periosteal estimation	0.9	2.2	2.4	-1.5	1.5
Bone: periosteal perimeter	0.5	1.1	1.1	-1.0	1.0
Bone: post-yield work	2.4	4.2	4.3	-2.1	2.0
Progressive ratio test 1 active lever presses	0.3	0.6	0.6	-0.8	0.7
Progressive ratio test 1 breakpoint	0.3	0.6	0.6	-0.8	0.7
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.2	0.3	-0.4
Progressive ratio test 2 active lever presses	1.9	2.7	2.8	-1.7	1.6
Progressive ratio test 2 breakpoint	2.2	2.8	2.8	-1.7	1.7
Progressive ratio test 2 inactive lever presses	0.8	2.4	2.5	-1.6	1.5
Incentive Sensitization - Responses	0.0	0.1	0.1	-0.4	0.3
Incentive Sensitization - Breakpoint	0.1	0.3	0.3	-0.6	0.5
Sum of active levers in priming session hrs 5-6	1.5	1.4	1.5	1.2	-1.2
Progressive ratio	0.2	0.7	0.7	-0.9	0.8
Food seeking constrained by brief footshock	0.0	0.0	0.0	-0.2	0.2
Seeking ratio, punishment vs. effort	0.1	0.2	0.2	0.5	-0.5
Retroperitoneal fat weight	5.3	23.7	24.0	-4.9	4.8
Reaction time number correct	0.2	0.6	0.7	0.8	-0.8
Reaction time mean minus median	0.2	1.3	1.4	1.2	-1.1
Reaction time mean minus median AUC	0.2	1.6	1.7	1.3	-1.2
Reaction time num false alarms	0.0	0.0	0.0	0.1	-0.1
Reaction time num false alarms AUC	0.2	0.6	0.6	0.7	-0.7
Reaction time trials correct on left	0.2	0.6	0.7	0.8	-0.8
Reaction time trials on left	0.2	0.8	0.8	0.9	-0.9
Reaction time mean	0.1	0.2	0.2	0.5	-0.4
Reaction time mean AUC	0.0	0.0	0.0	0.2	-0.1
Median of all reaction times	0.0	0.0	0.0	0.2	-0.2
Reaction time omissions	0.8	1.2	1.3	1.1	-1.1
Reaction time false alarm rate	0.0	0.0	0.0	-0.1	0.0
Reaction time premature initiation rate	0.8	1.2	1.4	1.0	-1.2
Reaction time premature initiations	1.1	3.4	3.7	1.8	-1.9
Std. dev. reaction times	0.2	0.6	0.6	0.8	-0.7
Reaction time trials completed	0.2	0.8	0.8	0.9	-0.9
Reaction time trials AUC	0.2	0.5	0.6	0.8	-0.7
Run reversals in cocaine runway, females	0.1	0.1	0.2	-0.4	0.3
Run reversals in cocaine runway, males	0.3	0.3	0.4	-0.5	0.6
Latency to leave start box in cocaine runway	2.0	2.7	2.8	-1.7	1.6
Latency to leave start box in cocaine runway, F	0.2	0.3	0.3	-0.6	0.5
Latency to leave start box in cocaine runway, M	3.7	3.6	3.6	-1.9	1.9
Std. dev. time between licks in bursts	0.1	0.2	0.2	-0.4	0.4
Total sessions with >9 infusions	0.5	0.7	0.7	-0.9	0.8
Short access day 1 total inactive lever presses	0.1	0.3	0.3	-0.5	0.5
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.1	0.1
Short access day 1 total infusions	0.8	1.5	1.6	-1.3	1.2
Short access day 10 total infusions	1.4	2.4	2.5	-1.6	1.5
Short access total infusions	1.3	1.8	2.0	-1.4	1.3
Short access day 1 locomotion	0.1	0.2	0.2	-0.5	0.5
Short access day 10 total locomotion	0.2	0.9	1.0	-1.0	0.9
Short access total locomotion	0.6	0.9	1.0	-1.0	0.9
One hour access (0.3 mA shock)	3.0	3.6	3.7	-1.9	1.9
Compulsive drug intake	1.9	2.8	2.8	1.7	-1.7
One hour access (shock baseline)	3.2	8.3	8.3	-2.9	2.9
Social response proportion	0.0	0.0	0.0	-0.2	0.2
Social responses	0.2	0.3	0.3	0.6	-0.5
Social time	0.6	1.0	1.0	1.0	-1.0
Soleus weight	2.1	6.2	6.6	-2.4	2.6
Bone: stiffness	0.0	0.0	0.0	-0.0	-0.0
Tibialis anterior weight	8.6	29.5	29.9	5.4	-5.5
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.2	-0.4	0.4
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.2	-0.3
Time to tail flick, test, before self-admin	0.2	0.3	0.3	-0.6	0.5
Time to tail flick, test, after self-admin	0.0	0.0	0.0	0.2	-0.1
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.6	0.7	-0.8
Delta time to tail flick, test, before/after SA	0.9	1.1	1.2	1.1	-1.0
Tibia length	0.5	1.4	1.5	1.2	-1.2
Ambulatory time before self-admin	0.2	0.5	0.5	0.7	-0.7
Ambulatory time after self-admin	0.0	0.0	0.0	0.1	-0.0
Bone: tissue strength	0.5	0.5	0.5	-0.7	0.7
Total heroin consumption	9.5	11.2	11.2	3.3	-3.3
Bone: trabecular number	0.0	0.1	0.1	0.2	-0.3
Bone: trabecular spacing	0.0	0.1	0.1	0.3	-0.2
Bone: trabecular thickness	0.6	0.8	0.8	-0.9	0.9
Bone: trabecular tissue density	1.9	3.3	3.5	-1.8	1.9
Water consumed over 24 hours	0.4	0.7	0.8	0.8	-0.9
Number of responses in last shaping day	1.0	1.4	1.4	1.1	-1.2