Hub : Genes

Hlcs

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Hlcs 0.09 0.06 3.9e-10 0.1 0.1 0.1 0.1 1.3e-10 9.7e-11 5.8e-11 3.8e-11
2 Liver mRNA stability Hlcs 0.08 0.05 1.4e-10 0.09 0.09 0.09 0.09 5.0e-10 4.2e-10 4.3e-10 3.3e-10
3 Liver isoform ratio XM_039088794.1 0.03 0.02 4.9e-03 0.01 0.01 0.02 0.01 7.0e-02 5.0e-02 1.9e-03 7.1e-02
4 NAcc mRNA stability Hlcs 0.03 0.02 3.3e-03 0 0.02 0.01 0.01 1.6e-01 2.0e-03 3.1e-02 4.4e-02
5 OFC gene expression Hlcs 0.16 0.11 2.4e-03 0.12 0.04 0.1 0.1 1.0e-03 5.0e-02 1.9e-03 2.9e-03
6 NAcc gene expression Hlcs 0.06 0.04 5.0e-08 0.07 0.05 0.06 0.01 1.5e-08 2.4e-06 3.6e-07 8.1e-03
7 BLA gene expression Hlcs 0.08 0.06 3.6e-03 0.04 0.01 0.01 -0 5.7e-03 8.2e-02 5.4e-02 3.5e-01
8 Liver gene expression Hlcs 0.35 0.13 0.0e+00 0.28 0.29 0.29 0.28 3.2e-31 1.1e-32 2.3e-32 1.5e-31
9 Brain gene expression Hlcs 0.12 0.06 5.0e-12 0.13 0.12 0.13 0.13 2.1e-12 1.8e-11 3.0e-12 4.0e-12
10 Brain isoform ratio XM_039088795.1 0.04 0.03 4.9e-03 -0 0.01 0 0 4.1e-01 5.4e-02 2.7e-01 2.4e-01
11 Brain mRNA stability Hlcs 0.09 0.06 4.4e-05 0.04 0.04 0.03 0.04 1.4e-04 1.5e-04 6.3e-04 9.2e-05
12 Brain isoform ratio XM_039088796.1 0.06 0.04 1.1e-03 0.04 0.04 0.03 0.04 1.0e-04 2.8e-04 6.0e-04 2.5e-04
13 PL intron excision ratio chr11_33610143_33624134 0.04 0.03 1.6e-03 0.01 0.02 0.02 0.01 2.8e-02 3.4e-03 1.7e-03 9.5e-03
14 Adipose gene expression Hlcs 0.21 0.09 0.0e+00 0.16 0.23 0.22 0.23 5.0e-17 2.6e-25 1.5e-24 7.3e-25
15 PL isoform ratio XM_039088796.1 0.05 0.03 4.2e-05 0.04 0.04 0.04 0.04 3.7e-05 3.0e-05 2.5e-05 3.3e-05
16 Adipose mRNA stability Hlcs 0.16 0.07 1.1e-16 0.11 0.14 0.13 0.13 2.8e-12 2.4e-15 1.8e-14 1.1e-14
17 PL isoform ratio XM_039088794.1 0.06 0.04 2.9e-05 0.04 0.04 0.04 0.04 6.9e-05 5.8e-05 1.6e-05 9.4e-05
18 Liver isoform ratio XM_039088796.1 0.08 0.06 8.7e-05 0.04 0.03 0.02 0.04 2.8e-05 2.3e-04 1.3e-03 8.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
Bone: apparent density0.30.41.20.4-0.4-0.50.3-0.5-0.5-0.5-0.3-0.40.70.61.11.10.80.80.8-0.40.8
Area under the delay curve1.81.94.21.1-1.0-1.20.9-1.3-1.4-1.3-1.7-1.30.91.4-0.10.92.01.62.0-1.71.8
BMI with tail0.41.43.6-0.40.4-1.91.70.00.00.1-0.2-0.11.51.60.51.11.21.51.5-1.71.6
BMI without tail0.10.20.40.1-0.2-0.40.3-0.2-0.2-0.3-0.3-0.30.50.50.50.60.60.60.6-0.50.5
Body weight0.20.61.7-0.50.4-1.31.20.10.20.10.10.01.11.10.30.60.71.00.9-1.21.0
Weight adjusted by age0.60.71.81.2-1.30.8-0.9-1.1-0.8-1.3-1.1-1.0-0.8-0.5-0.8-0.30.3-0.20.1-0.3-0.2
Bone surface1.62.86.3-2.22.3-2.22.51.81.82.01.52.01.91.70.70.50.11.10.6-1.41.2
Bone volume1.01.74.0-1.61.5-1.92.01.21.21.11.01.31.71.60.90.80.41.20.8-1.31.2
Breakpoint value in progressive ratio session0.20.21.20.1-0.10.3-0.2-0.00.0-0.0-0.2-0.0-0.6-0.4-1.1-0.9-0.3-0.5-0.20.3-0.3
Number of licking bursts0.60.71.40.9-1.0-0.3-0.2-1.0-1.0-1.2-0.9-1.00.40.50.91.11.10.80.9-0.50.7
Context. condit. distance diff. score0.30.43.00.3-0.30.4-0.3-0.2-0.3-0.2-0.7-0.3-0.8-0.5-1.7-1.2-0.2-0.6-0.20.1-0.4
Locomotion velocity, session 10.10.10.3-0.20.30.3-0.20.30.30.40.40.3-0.2-0.40.1-0.2-0.5-0.4-0.50.5-0.5
Locomotion distance, session 10.30.41.2-0.50.80.10.10.50.51.10.40.5-0.4-0.5-1.0-0.9-0.7-0.7-0.60.3-0.6
Locomotion velocity, session 20.30.30.8-0.20.40.5-0.30.40.40.60.30.3-0.6-0.7-0.8-0.9-0.8-0.8-0.70.6-0.8
Locomotion distance, session 20.10.20.60.6-0.4-0.30.1-0.6-0.6-0.3-0.8-0.70.00.1-0.40.10.60.30.5-0.20.3
Locomotion velocity, session 33.03.59.1-2.52.70.00.72.62.53.02.52.5-0.1-0.6-0.5-1.4-2.2-1.3-1.90.8-1.3
Locomotion distance, session 30.40.51.0-0.60.9-1.00.90.40.41.00.50.20.90.70.90.80.20.60.3-0.40.5
Stereotopy head waving bouts, day 31.82.15.5-1.51.50.8-0.51.71.71.82.31.8-0.1-0.81.70.1-1.8-1.0-1.91.2-1.4
Stereotopy head waving duration, day 31.51.74.7-1.51.40.7-0.31.61.71.52.21.7-0.1-0.71.4-0.0-1.7-0.9-1.71.0-1.2
Locomotion velocity, session 70.80.81.81.3-1.21.0-1.2-1.1-1.2-1.0-1.1-1.1-1.0-0.9-0.5-0.30.2-0.5-0.10.7-0.5
Locomotion distance, session 71.72.15.52.3-1.90.3-0.8-2.3-2.3-1.6-2.3-2.3-0.6-0.2-0.50.51.50.41.1-0.10.4
Stereotopy head waving bouts, day 73.33.76.8-2.22.10.9-0.22.52.52.32.62.5-0.7-1.2-0.4-1.6-2.6-1.8-2.41.5-1.8
Stereotopy head waving duration, day 73.34.07.1-2.32.20.80.02.62.62.32.42.7-0.8-1.1-1.3-2.2-2.6-1.8-2.31.4-1.8
Locomotion velocity, session 82.22.65.7-2.22.20.10.62.32.32.42.12.3-0.1-0.5-0.5-1.3-1.9-1.1-1.60.7-1.1
Locomotion distance, session 80.30.42.70.6-0.40.1-0.1-0.5-0.6-0.2-1.0-0.6-0.6-0.3-1.7-0.90.2-0.30.2-0.1-0.1
Degree of sensitization distance1.51.53.71.9-1.81.0-1.3-1.7-1.8-1.5-1.8-1.5-1.2-0.8-1.1-0.40.6-0.40.30.5-0.3
Degree of sensitization stereotypy2.32.65.6-2.22.10.00.72.32.32.12.12.4-0.2-0.4-1.0-1.6-1.9-1.1-1.50.6-1.0
Conditioned locomotion0.40.40.90.9-0.90.8-0.9-0.7-0.7-0.8-0.6-0.7-0.8-0.7-0.6-0.4-0.1-0.5-0.20.5-0.5
Cocaine response after cond. corrected0.91.02.20.10.01.2-0.90.20.20.30.10.2-1.3-1.4-1.5-1.5-1.1-1.4-1.11.3-1.3
Cocaine response after cond. not corrected1.11.23.10.6-0.31.3-1.1-0.3-0.20.1-0.4-0.2-1.5-1.5-1.8-1.6-0.9-1.4-1.01.3-1.3
Cocaine response before conditioning0.20.20.60.6-0.4-0.10.0-0.6-0.6-0.3-0.7-0.6-0.00.2-0.4-0.00.50.20.5-0.40.3
Saline control response0.40.51.2-0.91.00.00.20.90.91.10.90.8-0.2-0.3-0.5-0.7-0.9-0.6-0.70.2-0.6
Bone: connectivity density0.40.61.4-0.50.6-1.21.10.30.30.40.30.41.11.10.90.90.61.00.7-0.90.9
Bone: cortical apparent density0.10.20.50.1-0.2-0.40.4-0.2-0.1-0.3-0.2-0.10.50.60.30.50.50.50.6-0.70.6
Bone: cortical area0.30.41.4-0.40.30.5-0.20.50.50.40.30.5-0.7-0.6-1.1-1.2-0.8-0.8-0.70.5-0.7
Bone: cortical porosity0.20.20.60.7-0.80.4-0.6-0.6-0.6-0.8-0.6-0.6-0.3-0.3-0.00.10.2-0.10.10.2-0.1
Bone: cortical porosity0.30.30.80.9-0.90.2-0.4-0.8-0.9-0.9-0.9-0.8-0.2-0.1-0.20.10.50.20.4-0.10.2
Bone: cortical thickness1.52.55.41.4-1.52.3-2.2-0.9-0.9-1.2-0.9-0.9-2.2-2.0-1.8-1.8-0.9-1.7-1.21.6-1.7
Bone: cortical thickness0.30.31.10.9-1.00.5-0.6-0.8-0.8-1.1-0.8-0.8-0.4-0.1-0.3-0.10.4-0.00.3-0.10.1
Bone: cortical tissue density0.20.20.6-0.0-0.1-0.50.5-0.1-0.1-0.3-0.1-0.10.60.70.40.50.50.60.6-0.80.7
Condit. Reinf. active minus inactive responses0.00.00.00.0-0.10.2-0.10.0-0.0-0.0-0.0-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.10.2-0.1
Condit. Reinf. active-inactive response ratio0.30.30.80.3-0.30.9-0.8-0.1-0.2-0.1-0.1-0.3-0.8-0.8-0.5-0.7-0.5-0.7-0.60.9-0.7
Condit. Reinf. active responses0.00.00.1-0.10.0-0.10.20.10.0-0.0-0.10.00.00.1-0.3-0.20.00.00.1-0.10.1
Condit. Reinf. inactive responses0.00.00.2-0.30.3-0.10.20.30.30.30.20.40.10.0-0.1-0.1-0.2-0.1-0.10.0-0.1
Incentive salience index mean0.10.10.20.3-0.40.2-0.2-0.3-0.4-0.4-0.4-0.4-0.2-0.1-0.3-0.10.2-0.00.10.1-0.0
Condit. Reinf. lever presses0.20.30.70.7-0.80.6-0.6-0.5-0.6-0.8-0.7-0.6-0.7-0.5-0.9-0.60.1-0.3-0.00.4-0.3
Condit. Reinf. active minus inactive responses0.20.21.7-0.40.4-0.50.70.30.30.4-0.20.30.00.3-1.3-0.80.00.00.3-0.40.2
Condit. Reinf. active-inactive response ratio0.80.81.90.4-0.4-1.10.9-0.6-0.6-0.6-0.9-0.60.71.0-0.30.51.21.11.4-1.31.3
Condit. Reinf. active responses0.81.12.3-1.21.30.20.31.31.21.51.01.3-0.4-0.6-1.2-1.4-1.2-1.0-1.10.6-0.9
Condit. Reinf. inactive responses1.82.23.9-1.31.60.9-0.41.61.51.91.61.6-0.9-1.3-0.8-1.5-2.0-1.6-1.91.5-1.7
Condit. Reinf. lever presses0.40.50.9-1.00.9-0.10.41.01.00.90.70.9-0.1-0.1-0.8-0.9-0.7-0.5-0.6-0.0-0.4
Condit. Reinf. lever reinforcers received0.71.02.4-1.21.4-0.00.51.31.31.51.01.3-0.3-0.4-1.2-1.3-1.1-0.8-0.90.4-0.7
Conditioned reinforcement - actives0.50.51.50.9-0.9-0.20.0-1.0-1.0-0.9-1.2-1.0-0.20.2-0.9-0.20.80.30.8-0.30.5
Conditioned reinforcement - inactives1.61.84.11.2-1.11.9-1.9-0.8-0.8-0.7-0.9-0.8-2.0-1.8-1.6-1.6-0.8-1.5-1.01.5-1.3
Conditioned locomotion0.10.10.40.5-0.40.5-0.6-0.4-0.4-0.3-0.3-0.4-0.4-0.50.0-0.1-0.1-0.3-0.20.4-0.3
Patch foraging indifference point 0 sec2.43.98.50.8-0.92.9-2.6-0.2-0.1-0.4-0.1-0.2-2.8-2.7-2.0-2.4-1.9-2.6-2.22.5-2.6
Patch foraging indifference point AUC1.31.52.8-1.51.50.20.31.61.71.71.41.4-0.4-0.6-1.1-1.4-1.5-1.1-1.30.8-1.0
Delay disc. indifference point, 0s delay1.11.23.20.4-0.3-1.41.2-0.5-0.6-0.7-0.9-0.51.01.4-0.20.71.41.41.6-1.81.5
Delay disc. indifference point, 16s delay0.80.81.50.5-0.4-0.90.6-0.7-0.7-0.6-0.7-0.80.91.00.91.21.21.21.2-1.11.2
Delay disc. indifference point, 2s delay1.41.53.30.4-0.4-1.51.3-0.7-0.8-0.8-0.9-0.71.31.60.41.11.71.71.8-1.71.8
Delay disc. indifference point, 24s delay1.11.12.51.3-1.4-0.1-0.2-1.5-1.4-1.5-1.6-1.5-0.10.4-0.50.21.20.61.1-0.80.7
Delay disc. indifference point, 4s delay1.31.33.10.6-0.6-1.31.1-0.8-0.9-0.9-1.2-0.81.01.4-0.10.81.61.41.8-1.61.6
Delay disc. indifference point, 8s delay0.91.02.31.3-1.1-0.30.1-1.2-1.3-1.3-1.5-1.20.10.5-0.60.21.30.71.2-0.80.9
Indifference point function ln k0.60.82.01.3-1.40.8-1.0-1.2-1.2-1.4-1.1-1.0-0.8-0.5-0.6-0.20.4-0.20.20.2-0.2
Indifference point function log k0.60.82.01.3-1.40.8-1.0-1.2-1.2-1.4-1.1-1.0-0.8-0.5-0.6-0.20.4-0.20.20.2-0.2
Patch foraging total patch changes 0 sec2.13.47.10.5-0.62.7-2.30.00.1-0.20.10.0-2.6-2.5-2.0-2.4-1.9-2.5-2.12.3-2.4
Patch foraging total patch changes 12 sec1.92.44.7-1.51.41.0-0.41.71.91.61.71.6-1.0-1.3-1.0-1.7-2.2-1.7-2.01.4-1.7
Patch foraging total patch changes 18 sec1.72.14.5-1.11.01.3-0.61.41.31.21.11.3-1.3-1.4-1.6-2.1-2.0-1.8-1.81.4-1.7
Patch foraging total patch changes 24 sec0.60.72.8-0.80.70.30.10.81.00.70.50.8-0.6-0.5-1.7-1.5-0.9-0.9-0.70.3-0.7
Patch foraging total patch changes 6 sec2.94.28.1-1.11.22.0-1.41.51.61.81.71.5-2.0-2.3-1.5-2.4-2.8-2.7-2.82.7-2.7
Patch foraging time to switch 0 sec0.61.02.50.4-0.2-1.10.7-0.7-0.7-0.3-0.5-0.61.11.11.41.61.31.31.2-1.01.2
Patch foraging water rate 0 sec1.42.24.5-1.91.70.50.12.12.11.72.02.1-0.4-0.7-0.6-1.4-2.0-1.2-1.71.0-1.3
Patch foraging water rate 12 sec1.32.04.11.5-1.32.0-2.0-1.1-1.1-1.0-1.1-1.0-2.0-1.8-1.7-1.5-0.6-1.5-0.91.3-1.4
Patch foraging water rate 18 sec0.30.51.1-0.60.5-0.90.90.40.50.20.30.60.90.90.60.50.40.80.6-1.00.8
Patch foraging water rate 24 sec0.40.52.10.9-0.90.4-0.3-0.8-0.8-1.0-1.1-0.7-0.6-0.1-1.4-0.80.4-0.10.4-0.30.1
Patch foraging water rate 6 sec0.10.21.00.3-0.40.5-0.4-0.2-0.3-0.4-0.5-0.2-0.6-0.4-1.0-0.9-0.1-0.4-0.10.2-0.3
Seeking ratio, delayed vs. immediate footshock0.91.02.50.6-0.8-0.80.4-0.8-0.6-1.2-0.6-0.81.00.91.61.61.31.21.2-0.81.2
Distance traveled before self-admin0.00.10.3-0.20.2-0.20.30.30.20.20.00.20.00.1-0.6-0.4-0.1-0.00.0-0.20.1
Distance traveled after self-admin1.21.32.60.2-0.2-1.41.1-0.5-0.5-0.6-0.4-0.61.41.41.31.61.41.51.5-1.51.5
Extensor digitorum longus weight2.39.219.9-4.54.2-3.23.83.93.83.73.73.73.22.62.41.3-0.71.60.0-1.91.4
Bone: elastic displacement0.20.20.50.6-0.70.4-0.5-0.6-0.5-0.7-0.4-0.4-0.2-0.20.40.40.20.00.1-0.0-0.1
Bone: elastic work0.10.20.4-0.20.10.6-0.40.30.30.10.40.5-0.3-0.50.1-0.3-0.6-0.5-0.60.3-0.6
Bone: endosteal estimation2.24.811.3-2.32.4-3.33.41.61.62.01.41.72.92.71.61.61.02.21.5-2.42.2
Bone: endosteal perimeter0.71.53.5-1.71.9-1.61.81.41.41.81.01.31.11.0-0.3-0.2-0.10.50.2-1.00.6
Epididymis fat weight2.04.712.4-2.62.7-3.23.52.12.12.11.61.92.62.60.50.60.51.81.2-2.51.9
Delta time in closed arm before/after self-admin1.21.12.30.5-0.5-1.20.8-0.8-0.7-0.7-0.7-0.81.11.21.01.51.41.31.4-1.21.3
Delta time in open arm before/after self-admin0.20.20.6-0.80.7-0.40.60.70.60.50.60.70.50.40.30.1-0.10.2-0.0-0.30.2
Diff in mean of infusions in LGA sessions2.22.55.1-1.31.31.0-0.41.61.61.71.31.6-1.2-1.4-2.0-2.3-2.1-1.8-1.91.4-1.7
Delay discount exponential model param1.71.73.7-1.11.01.1-0.81.31.41.31.71.3-0.8-1.30.2-0.8-1.9-1.5-1.91.6-1.6
Extinction: sum of active levers before priming0.90.92.7-0.70.70.6-0.20.90.90.80.60.9-0.8-0.8-1.5-1.6-1.2-1.1-1.00.8-1.0
Active lever presses in extinction session 63.23.16.7-0.50.52.2-1.91.01.01.11.31.0-1.9-2.3-0.5-1.5-2.4-2.3-2.62.5-2.4
Bone: final force0.20.41.0-0.90.9-0.20.50.90.90.90.81.00.10.0-0.2-0.5-0.6-0.2-0.40.0-0.2
Bone: final moment0.30.41.1-0.90.9-0.10.41.00.90.90.81.10.0-0.1-0.3-0.6-0.7-0.4-0.50.1-0.3
Food consumed during 24 hour testing period0.60.71.50.7-0.61.2-1.2-0.5-0.4-0.4-0.3-0.5-1.2-1.2-0.9-0.9-0.6-1.0-0.81.1-1.0
Glucose2.53.79.0-3.03.0-0.91.62.92.83.02.72.80.80.30.1-0.7-1.6-0.4-1.20.0-0.5
Heart weight2.02.85.6-0.60.4-2.21.90.10.1-0.20.30.12.42.32.32.41.62.21.8-2.12.1
Delay discount hyperbolic model param1.71.84.0-1.00.91.2-1.01.11.31.31.51.1-1.0-1.50.0-0.9-1.9-1.6-2.01.7-1.8
Intermittent access intake day 1-15 change1.01.02.50.4-0.41.6-1.4-0.00.0-0.2-0.00.0-1.4-1.3-0.9-1.1-1.0-1.3-1.21.1-1.3
Intermittent access intake escalation1.11.12.40.3-0.31.6-1.40.00.1-0.00.10.1-1.4-1.5-0.8-1.1-1.1-1.4-1.31.5-1.4
Intermittent access intake escalation 22.22.13.9-0.10.31.8-1.50.60.60.80.60.7-1.8-1.9-1.3-1.8-1.8-2.0-1.92.0-2.0
Intermitt. access day 1 inactive lever presses1.61.74.21.5-1.32.0-2.0-1.0-1.0-0.9-0.9-1.0-1.9-1.5-1.1-1.0-0.5-1.3-0.91.2-1.4
Intermitt. access day 15 inactive lever presses1.01.13.20.4-0.41.3-1.2-0.1-0.1-0.1-0.4-0.1-1.6-1.3-1.8-1.8-0.9-1.4-1.01.1-1.1
Intermitt. access escalation Index0.10.10.30.2-0.50.6-0.4-0.1-0.2-0.5-0.2-0.2-0.4-0.3-0.3-0.4-0.1-0.2-0.20.3-0.3
Intermittent access day 1 total infusions0.50.62.10.8-0.90.8-0.7-0.6-0.7-0.8-1.0-0.6-1.0-0.6-1.5-1.2-0.0-0.6-0.10.2-0.3
Intermittent access day 15 total infusions2.93.27.01.0-1.02.6-2.5-0.4-0.4-0.3-0.5-0.4-2.7-2.5-2.0-2.2-1.6-2.3-1.92.2-2.1
Intermittent access terminal intake (last 3 days)2.12.35.31.1-1.12.2-2.2-0.6-0.6-0.6-0.7-0.6-2.3-2.0-1.8-1.9-1.1-1.9-1.41.7-1.6
Intermittent access total infusions1.61.84.11.0-1.01.9-1.8-0.6-0.6-0.6-0.7-0.6-2.0-1.7-1.8-1.8-0.9-1.6-1.11.4-1.4
Intermittent access day 1 locomotion1.41.42.91.6-1.71.2-1.3-1.3-1.4-1.6-1.6-1.4-1.3-0.8-1.4-1.00.4-0.50.20.6-0.3
Intermittent access day 15 total locomotion2.02.15.00.3-0.31.9-1.60.20.20.2-0.10.2-2.1-1.9-2.0-2.2-1.5-2.0-1.71.7-1.8
Intermittent access total locomotion2.93.47.61.1-1.12.4-2.2-0.6-0.5-0.5-0.9-0.5-2.7-2.4-2.8-2.7-1.4-2.3-1.62.0-1.9
Intermittent access standard deviation1.41.53.00.10.11.7-1.60.30.30.60.50.4-1.5-1.7-0.5-1.1-1.5-1.6-1.71.7-1.7
Left kidney weight1.64.510.02.8-2.9-0.2-0.5-3.0-2.9-3.2-3.2-2.9-0.20.6-0.90.72.51.22.3-1.21.4
Right kidney weight1.54.210.03.0-2.90.4-1.1-3.0-2.9-3.0-3.2-3.1-0.9-0.1-1.40.11.90.51.6-0.40.8
Cocaine induced anxiety0.40.41.2-0.20.20.5-0.50.30.40.40.20.3-0.8-0.9-0.9-1.1-0.8-1.0-0.80.6-0.6
Post-drug Anxiety0.91.02.6-0.80.90.3-0.20.91.01.20.70.9-0.8-1.0-1.4-1.6-1.3-1.3-1.20.7-0.8
Baseline Anxiety0.00.00.2-0.00.20.20.00.1-0.00.30.10.1-0.0-0.0-0.00.0-0.10.0-0.10.2-0.4
Tail length0.51.53.41.0-1.01.9-1.8-0.6-0.5-0.8-0.6-0.7-1.7-1.6-1.3-1.4-0.8-1.3-1.01.4-1.3
Length with tail0.00.20.40.3-0.50.6-0.6-0.3-0.1-0.5-0.2-0.4-0.6-0.4-0.5-0.5-0.2-0.4-0.20.4-0.3
Length without tail0.00.00.1-0.00.1-0.20.2-0.00.10.00.0-0.00.10.1-0.2-0.20.00.00.1-0.10.1
Times rat made contact with spout4.75.511.63.0-2.83.1-3.4-2.5-2.4-2.3-2.1-2.3-2.9-2.7-1.6-1.2-0.4-1.9-1.02.3-1.9
Lifetime Intake0.50.51.10.8-0.81.0-1.0-0.6-0.6-0.6-0.6-0.6-1.1-0.9-0.9-0.8-0.3-0.7-0.40.6-0.6
Liver weight, left0.20.30.90.6-0.70.5-0.4-0.4-0.4-0.8-0.6-0.5-0.6-0.3-0.9-0.60.0-0.30.10.2-0.2
Liver weight, right0.20.30.80.7-0.5-0.30.0-0.8-0.7-0.4-0.7-0.90.20.30.20.50.70.40.6-0.30.4
Locomotor activity2.03.17.82.8-2.51.4-1.9-2.6-2.4-2.3-2.5-2.3-1.6-1.2-1.3-0.50.9-0.50.40.4-0.3
Locomotor testing distance1.11.83.81.7-1.51.8-1.9-1.4-1.2-1.1-1.2-1.0-1.8-1.6-1.1-0.9-0.3-1.2-0.71.2-1.1
Locomotor testing rearing0.60.92.31.4-1.30.5-0.6-1.4-1.3-1.3-1.5-1.2-0.5-0.2-0.8-0.20.80.10.6-0.10.2
Locomotion in novel chamber0.30.40.90.2-0.30.9-0.80.00.1-0.2-0.00.1-0.9-0.9-0.9-0.8-0.7-0.8-0.70.3-0.8
Locomotion in novel chamber post-restriction1.11.42.8-1.31.2-1.41.40.90.90.81.21.01.61.31.71.30.31.10.5-1.20.9
Fecal boli incidents, locomotor time 11.01.12.41.0-1.1-0.70.5-1.2-1.1-1.4-1.5-1.20.20.7-1.1-0.11.40.91.5-1.01.1
Change in fecal boli incidents, locomotor task1.21.12.81.7-1.51.1-1.3-1.4-1.3-1.3-1.3-1.4-1.0-0.8-0.4-0.00.4-0.40.11.0-0.3
Time >=10cm from walls, locomotor time 10.90.92.20.1-0.31.4-1.20.10.1-0.10.10.1-1.2-1.2-0.8-1.1-1.0-1.2-1.11.5-1.2
Bouts of movement, locomotor time 10.10.20.3-0.40.30.3-0.10.50.40.40.50.5-0.2-0.2-0.2-0.4-0.5-0.4-0.5-0.5-0.4
Total resting periods, locomotor time 10.10.10.3-0.30.20.3-0.10.40.30.30.40.4-0.3-0.3-0.5-0.6-0.5-0.4-0.5-0.3-0.4
Rest time, locomotor task time 11.21.33.00.3-0.1-1.71.4-0.6-0.7-0.4-0.9-0.61.21.5-0.30.71.61.51.7-1.61.6
Distance moved, locomotor task time 10.40.52.1-0.0-0.10.9-0.90.20.2-0.10.60.2-0.3-0.71.40.6-0.6-0.5-0.81.4-0.7
Vertical activity count, locomotor time 11.01.02.3-0.70.71.1-0.81.01.00.81.31.0-0.7-1.00.4-0.5-1.5-1.1-1.51.3-1.3
Time >=10cm from walls, locomotor time 20.50.51.7-0.90.7-0.70.70.70.60.50.80.70.90.71.30.90.10.60.1-0.30.5
Bouts of movement, locomotor time 20.80.91.7-1.31.3-0.91.21.21.21.20.71.20.40.6-1.3-1.0-0.40.00.0-0.80.2
Total resting periods, locomotor time 20.40.42.5-0.60.7-0.30.60.60.60.60.10.6-0.10.1-1.6-1.2-0.3-0.2-0.0-0.5-0.0
Rest time, locomotor task time 20.70.83.40.8-0.60.8-0.8-0.6-0.6-0.4-0.8-0.6-1.2-1.0-1.9-1.3-0.3-0.9-0.40.7-0.7
Distance moved, locomotor task time 21.21.47.3-0.80.7-1.10.90.60.60.40.90.61.61.22.72.10.51.20.5-0.81.0
Vertical activity count, locomotor time 21.01.12.8-1.10.9-1.11.10.90.90.61.00.91.41.21.71.30.31.00.4-0.90.8
Light reinforcement 10.40.72.00.3-0.3-1.00.8-0.5-0.5-0.5-0.7-0.60.81.00.10.61.11.01.2-1.41.1
Light reinforcement 21.72.35.8-2.22.0-2.02.41.81.61.61.31.61.71.70.10.10.11.10.6-1.61.1
Bone: marrow area2.24.811.3-2.32.4-3.33.41.71.62.01.41.72.92.71.51.51.02.11.5-2.42.1
Bone: maximum diameter0.50.82.0-1.41.4-0.60.91.31.31.31.01.30.30.2-0.7-0.8-0.7-0.2-0.4-0.1-0.1
Bone: maximum force0.30.51.2-1.01.0-0.30.51.01.01.01.01.10.30.10.4-0.1-0.6-0.1-0.5-0.0-0.2
Bone: maximum moment0.20.41.1-1.00.9-0.20.51.00.90.80.91.00.30.10.2-0.2-0.6-0.1-0.4-0.0-0.2
Mean time between licks in bursts1.11.54.22.1-1.71.1-1.5-1.9-1.9-1.5-1.4-1.6-0.9-0.90.20.50.6-0.30.20.6-0.3
Mean num. licks in bursts1.92.34.50.5-0.32.1-1.8-0.00.00.20.10.0-2.0-2.1-1.6-1.9-1.6-2.1-1.82.0-2.0
Cd content in liver0.70.82.40.9-0.81.4-1.6-0.6-0.6-0.6-0.2-0.7-1.0-1.20.3-0.1-0.5-0.9-0.81.3-1.0
Co content in liver0.10.10.3-0.0-0.0-0.50.4-0.1-0.1-0.2-0.2-0.10.40.50.00.30.40.50.5-0.50.5
Cu content in liver0.10.10.3-0.40.30.2-0.10.40.40.30.50.5-0.0-0.10.4-0.1-0.4-0.2-0.40.3-0.3
Fe content in liver1.62.04.1-1.41.21.1-0.71.71.71.32.01.7-0.5-1.10.7-0.5-2.0-1.3-2.01.5-1.5
K content in liver0.80.71.7-0.70.6-1.11.10.50.50.40.50.41.21.11.31.00.51.00.6-1.00.9
Mg content in liver0.70.72.1-1.00.9-0.70.80.90.90.71.10.91.00.71.40.8-0.10.60.0-0.50.4
Mn content in liver0.80.92.4-0.60.7-1.51.60.30.30.50.10.31.31.40.20.50.81.21.1-1.41.2
Na content in liver2.22.35.4-2.32.3-0.61.22.22.22.32.12.30.50.20.1-0.8-1.4-0.4-1.00.1-0.4
Rb content in liver0.30.41.40.8-1.00.2-0.4-0.8-0.8-1.2-0.7-0.8-0.00.10.30.40.60.40.5-0.20.3
Se content in liver0.81.02.2-0.10.01.4-1.30.50.50.30.90.5-0.9-1.20.7-0.3-1.3-1.2-1.51.5-1.4
Sr content in liver1.41.32.91.7-1.70.8-1.1-1.6-1.6-1.6-1.6-1.6-0.8-0.6-0.6-0.10.7-0.20.40.3-0.1
Zn content in liver0.80.91.80.2-0.21.3-1.10.10.10.10.10.1-1.3-1.3-0.8-1.1-1.0-1.3-1.21.3-1.3
Bone: minimum diameter2.03.78.9-3.03.0-1.92.32.62.62.92.42.61.61.20.70.1-0.80.5-0.3-0.80.4
Time in familiar zone, hab. session 10.20.20.80.4-0.2-0.20.2-0.4-0.4-0.1-0.6-0.5-0.10.1-0.9-0.30.40.10.4-0.50.3
Time in novel zone, hab. session 11.00.94.9-0.90.7-0.90.80.70.70.51.00.81.30.92.21.50.20.90.2-0.40.7
Total zone transitions, hab. session 11.11.53.51.9-1.61.0-1.2-1.7-1.7-1.3-1.8-1.6-1.3-0.9-1.6-0.70.5-0.50.20.5-0.4
Total locomotion distance, hab. session 10.91.33.21.8-1.60.9-1.2-1.7-1.7-1.4-1.6-1.8-1.0-0.7-0.9-0.30.6-0.30.30.3-0.2
Locomotion velocity, hab. session 11.01.53.51.9-1.71.0-1.3-1.7-1.7-1.5-1.7-1.8-1.1-0.8-0.9-0.20.6-0.30.30.4-0.3
Time in familiar zone, hab. session 20.60.71.8-0.10.2-1.21.2-0.1-0.10.1-0.5-0.20.81.1-0.40.31.01.01.1-1.41.1
Time in novel zone, hab. session 20.20.20.80.1-0.20.6-0.70.00.0-0.30.40.1-0.2-0.40.90.3-0.4-0.3-0.50.6-0.5
Total zone transitions, hab. session 21.11.44.41.7-1.3-0.1-0.3-1.8-1.7-1.2-2.1-1.7-0.5-0.1-1.4-0.21.20.31.1-0.30.5
Total locomotion distance, hab. session 22.12.87.32.5-2.20.1-0.7-2.5-2.5-2.1-2.7-2.5-0.50.0-0.90.41.80.61.5-0.50.8
Locomotion velocity, hab. session 22.02.77.12.5-2.20.1-0.7-2.5-2.5-2.0-2.7-2.5-0.6-0.0-0.90.31.70.51.4-0.40.7
Novel to familiar place preference ratio0.30.42.30.2-0.1-0.40.1-0.3-0.4-0.10.1-0.30.70.51.51.30.50.60.4-0.40.5
Novelty place preference0.70.73.5-0.10.1-0.80.6-0.1-0.2-0.00.2-0.21.10.91.91.60.81.10.7-0.80.9
Time in novel zone, NPP test0.80.83.4-0.20.2-1.00.8-0.0-0.10.10.3-0.01.31.11.91.60.81.20.8-1.01.0
Total zone transitions, NPP test0.20.32.20.5-0.30.3-0.2-0.4-0.4-0.2-0.7-0.3-0.7-0.5-1.5-0.90.0-0.4-0.00.3-0.3
Total locomotion distance, NPP test0.30.51.21.0-0.8-0.1-0.2-1.0-1.0-0.8-1.0-1.1-0.00.1-0.10.40.80.40.7-0.20.4
Locomotion velocity, NPP test0.40.61.61.2-1.00.1-0.4-1.2-1.2-1.0-1.2-1.3-0.2-0.1-0.20.30.80.20.6-0.10.3
Intraocular pressure0.40.62.3-0.20.1-0.70.60.20.1-0.10.30.31.10.91.51.30.60.90.6-0.90.8
Delta distance traveled before/after self-admin1.81.93.60.9-0.9-1.20.8-1.3-1.2-1.2-1.2-1.31.21.41.21.71.91.71.8-1.61.7
Delta ambulatory time before/after self-admin1.82.03.91.1-1.0-1.20.7-1.5-1.4-1.3-1.4-1.41.11.30.91.62.01.61.9-1.51.7
Parametrial fat weight1.32.66.3-1.01.0-2.52.40.50.70.50.30.22.22.21.21.61.42.01.7-2.22.0
Pavlov. Cond. lever latency0.20.20.40.4-0.3-0.30.1-0.5-0.5-0.3-0.5-0.50.30.40.40.60.60.50.6-0.60.5
Pavlov. Cond. magazine entry latency0.30.40.90.9-0.90.3-0.5-0.9-0.9-0.9-0.7-0.9-0.2-0.10.20.40.50.20.40.10.2
Pavlov. Cond. change in total contacts0.00.00.20.2-0.30.1-0.1-0.2-0.1-0.4-0.3-0.3-0.2-0.0-0.5-0.30.1-0.00.1-0.10.1
Pavlov. Cond. index score0.10.10.20.3-0.30.3-0.4-0.2-0.2-0.3-0.1-0.2-0.3-0.3-0.2-0.1-0.1-0.2-0.10.5-0.2
Pavlov. Cond. latency score0.10.10.20.4-0.40.3-0.4-0.4-0.3-0.5-0.3-0.3-0.3-0.3-0.2-0.10.0-0.1-0.00.4-0.1
Pavlov. Cond. lever contacts0.50.61.4-0.0-0.10.9-0.70.20.20.10.10.2-1.0-1.0-1.1-1.2-0.9-1.0-0.91.0-1.0
Pavlov. Cond. magazine entry number0.10.10.2-0.30.3-0.00.20.40.30.40.20.4-0.1-0.1-0.5-0.4-0.3-0.2-0.2-0.1-0.2
Pavlov. Cond. intertrial magazine entries4.35.311.6-3.32.90.20.73.43.43.03.43.30.1-0.60.2-1.3-2.7-1.3-2.41.0-1.6
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.3-0.30.3-0.3-0.2-0.1-0.3-0.1-0.2-0.3-0.3-0.2-0.1-0.1-0.2-0.10.4-0.2
Pavlov. Cond. response bias0.20.20.40.4-0.50.6-0.6-0.3-0.3-0.4-0.3-0.3-0.6-0.5-0.5-0.5-0.2-0.5-0.30.6-0.4
Pavlov. Cond. lever latency0.81.02.31.5-1.40.4-0.9-1.5-1.5-1.4-1.1-1.4-0.1-0.11.11.20.90.40.60.20.3
Pavlov. Cond. magazine entry latency0.30.31.90.0-0.10.5-0.30.10.1-0.0-0.2-0.0-0.8-0.5-1.4-1.1-0.5-0.7-0.40.0-0.6
Pavlov. Cond. change in total contacts0.30.51.1-0.90.8-0.91.10.70.80.60.40.60.50.6-0.7-0.4-0.00.30.3-1.00.4
Pavlov. Cond. index score0.60.82.4-0.70.60.5-0.20.90.90.70.60.7-0.8-0.7-1.5-1.6-1.1-1.1-1.00.2-0.9
Pavlov. Cond. latency score0.30.42.2-0.30.20.5-0.20.40.40.20.10.2-0.8-0.6-1.5-1.3-0.7-0.8-0.6-0.0-0.7
Pavlov. Cond. lever contacts0.30.51.0-1.00.9-0.50.80.91.00.80.60.90.20.2-0.9-0.8-0.4-0.1-0.2-0.5-0.0
Pavlov. Cond. magazine entry number0.10.10.60.3-0.20.4-0.5-0.2-0.2-0.10.1-0.0-0.2-0.30.60.3-0.1-0.2-0.30.8-0.3
Pavlov. Cond. intertrial magazine entries0.30.40.8-0.70.80.3-0.00.80.70.90.80.9-0.2-0.40.2-0.4-0.8-0.5-0.80.8-0.6
Pavlov. Cond. lever-magazine prob. diff.0.60.72.7-0.60.50.5-0.20.70.80.60.40.5-0.8-0.7-1.6-1.6-1.0-1.0-0.90.1-0.9
Pavlov. Cond. response bias0.30.41.2-0.90.8-0.30.50.80.90.70.50.8-0.10.0-1.1-1.0-0.5-0.3-0.3-0.3-0.2
Time in closed arm before self-admin0.30.30.8-0.40.3-0.80.90.30.10.1-0.00.20.70.80.10.10.50.70.6-0.90.7
Time in closed arm after self-admin5.25.310.30.7-0.6-2.82.2-1.4-1.4-1.3-1.5-1.42.62.81.62.73.13.03.2-3.13.1
Time in open arm before self-admin0.10.10.30.4-0.40.1-0.3-0.6-0.4-0.3-0.4-0.4-0.2-0.1-0.10.10.2-0.00.10.1-0.0
Time in open arm after self-admin1.21.42.6-1.01.00.9-0.51.21.11.21.11.2-0.9-1.1-0.9-1.5-1.6-1.3-1.51.2-1.3
Bone: periosteal estimation0.71.53.2-1.71.7-1.61.81.41.41.51.11.41.31.20.40.2-0.00.70.3-1.00.7
Bone: periosteal perimeter0.30.61.5-1.01.1-0.30.61.01.01.20.70.9-0.1-0.1-0.9-1.0-0.7-0.5-0.5-0.1-0.4
Bone: post-yield work0.91.22.6-1.61.50.10.31.61.61.51.61.6-0.0-0.3-0.1-0.8-1.3-0.7-1.10.5-0.8
Progressive ratio test 1 active lever presses0.60.61.61.0-1.20.1-0.3-1.0-1.1-1.3-1.2-1.0-0.20.2-0.4-0.00.80.30.7-0.60.5
Progressive ratio test 1 breakpoint0.80.92.21.2-1.40.2-0.4-1.2-1.3-1.5-1.3-1.2-0.10.4-0.20.21.00.50.9-0.80.6
Progressive ratio test 1 inactive lever presses0.50.61.70.7-0.81.3-1.2-0.4-0.6-0.6-0.5-0.5-1.1-0.9-0.4-0.6-0.4-0.8-0.50.8-0.8
Progressive ratio test 2 active lever presses1.51.63.50.8-0.71.8-1.8-0.3-0.4-0.2-0.4-0.4-1.9-1.8-1.3-1.5-1.1-1.6-1.31.6-1.5
Progressive ratio test 2 breakpoint1.51.73.70.6-0.61.9-1.8-0.2-0.2-0.1-0.2-0.2-1.9-1.9-1.2-1.5-1.3-1.7-1.51.7-1.6
Progressive ratio test 2 inactive lever presses3.54.19.00.7-0.72.8-2.4-0.0-0.1-0.1-0.4-0.0-2.9-2.6-2.8-3.0-1.9-2.6-2.12.4-2.4
Incentive Sensitization - Responses1.71.83.2-0.50.61.4-1.10.80.81.10.80.8-1.5-1.6-1.3-1.7-1.8-1.7-1.81.7-1.7
Incentive Sensitization - Breakpoint2.02.13.8-0.50.61.5-1.20.90.91.10.80.9-1.7-1.8-1.4-1.8-1.9-1.9-1.91.9-1.8
Sum of active levers in priming session hrs 5-61.71.63.3-0.80.71.3-0.91.11.11.01.21.1-1.1-1.4-0.5-1.3-1.8-1.5-1.81.6-1.6
Progressive ratio0.10.10.3-0.40.30.3-0.10.50.50.20.50.5-0.2-0.2-0.2-0.4-0.5-0.3-0.5-0.1-0.3
Food seeking constrained by brief footshock0.70.91.81.4-1.31.1-1.4-1.1-1.3-1.1-0.9-1.1-0.9-0.8-0.10.20.1-0.4-0.11.0-0.6
Seeking ratio, punishment vs. effort0.60.71.91.3-1.10.4-0.8-1.3-1.4-1.0-1.0-1.3-0.3-0.20.50.70.70.20.40.30.1
Retroperitoneal fat weight1.03.26.5-2.42.3-2.32.51.92.02.01.91.82.11.81.20.90.01.30.5-1.61.1
Reaction time number correct0.20.30.7-0.30.30.5-0.20.30.30.40.30.3-0.5-0.5-0.8-0.9-0.7-0.7-0.60.5-0.6
Reaction time mean minus median0.60.81.80.4-0.51.3-1.1-0.10.0-0.40.00.1-1.2-1.1-0.9-1.0-0.9-1.1-1.01.2-1.1
Reaction time mean minus median AUC1.11.42.8-0.30.21.4-0.90.80.90.30.70.9-1.3-1.2-1.4-1.7-1.6-1.5-1.51.3-1.5
Reaction time num false alarms1.31.84.12.0-1.91.3-1.7-1.9-1.9-1.7-1.6-1.8-1.0-1.00.20.30.6-0.30.10.7-0.4
Reaction time num false alarms AUC1.72.45.92.4-2.21.1-1.6-2.3-2.4-2.1-2.1-2.3-0.9-0.70.20.51.10.00.60.40.0
Reaction time trials correct on left0.20.30.7-0.30.30.5-0.20.30.30.40.30.3-0.5-0.5-0.8-0.9-0.7-0.7-0.60.5-0.6
Reaction time trials on left0.20.30.7-0.30.40.5-0.20.30.30.40.30.3-0.5-0.5-0.8-0.9-0.7-0.7-0.60.5-0.7
Reaction time mean0.20.31.9-0.30.2-0.30.30.30.30.10.60.50.70.51.40.90.10.50.1-0.30.3
Reaction time mean AUC0.10.10.7-0.30.30.2-0.10.40.40.20.70.60.1-0.10.80.3-0.4-0.1-0.40.2-0.2
Median of all reaction times0.71.04.1-0.40.4-1.11.00.20.20.10.50.41.41.22.01.60.71.20.7-1.01.1
Reaction time omissions0.00.00.10.10.1-0.20.2-0.2-0.20.1-0.10.10.20.20.20.20.20.20.2-0.20.2
Reaction time false alarm rate1.52.14.92.2-2.10.8-1.4-2.1-2.2-2.1-1.9-2.1-0.6-0.50.60.91.20.30.70.30.3
Reaction time premature initiation rate0.60.82.1-0.80.7-1.31.40.50.70.20.30.61.21.20.40.40.51.00.8-1.11.1
Reaction time premature initiations0.30.40.9-0.90.8-0.61.00.80.90.60.60.80.50.5-0.3-0.4-0.20.20.1-0.40.3
Std. dev. reaction times0.30.51.40.6-0.61.2-1.1-0.3-0.2-0.4-0.0-0.1-0.9-0.9-0.2-0.4-0.6-0.8-0.71.0-0.9
Reaction time trials completed0.20.30.7-0.30.40.5-0.20.30.30.40.30.3-0.5-0.5-0.8-0.9-0.7-0.7-0.60.5-0.7
Reaction time trials AUC0.20.30.5-0.50.60.30.00.50.50.60.60.5-0.3-0.3-0.6-0.7-0.7-0.6-0.60.4-0.6
Run reversals in cocaine runway, females0.40.41.00.9-0.90.5-0.4-0.7-0.8-1.0-0.9-0.8-0.4-0.1-0.5-0.30.40.10.3-1.00.1
Run reversals in cocaine runway, males0.70.72.6-0.10.10.7-0.60.30.50.30.00.3-1.0-1.1-1.5-1.6-0.9-1.1-0.90.4-0.8
Latency to leave start box in cocaine runway0.30.40.70.3-0.3-0.70.4-0.5-0.4-0.5-0.4-0.50.70.70.70.80.80.80.8-0.20.8
Latency to leave start box in cocaine runway, F1.01.12.70.9-0.7-0.80.3-1.2-1.1-0.9-0.8-1.20.90.91.41.61.41.21.3-0.51.1
Latency to leave start box in cocaine runway, M0.20.20.6-0.80.7-0.30.50.70.70.60.50.70.10.1-0.5-0.5-0.4-0.1-0.20.1-0.0
Std. dev. time between licks in bursts1.11.42.80.4-0.41.7-1.4-0.1-0.1-0.00.00.1-1.6-1.6-1.3-1.4-1.2-1.6-1.31.5-1.6
Total sessions with >9 infusions0.80.91.91.2-1.2-0.1-0.2-1.2-1.3-1.4-1.1-1.30.30.40.71.01.20.81.0-0.50.7
Short access day 1 total inactive lever presses1.21.33.61.1-1.01.8-1.9-0.6-0.7-0.5-0.5-0.7-1.7-1.7-0.6-0.9-0.8-1.3-1.11.3-1.3
Short access day 10 total inactive lever presses0.60.61.8-0.81.00.2-0.20.91.01.31.31.0-0.1-0.40.60.0-1.0-0.6-1.00.2-0.7
Short access day 1 total infusions0.20.20.80.3-0.5-0.1-0.1-0.4-0.5-0.6-0.3-0.50.40.40.90.80.50.50.4-0.40.4
Short access day 10 total infusions0.50.61.20.2-0.5-0.60.4-0.4-0.5-0.7-0.4-0.50.80.91.11.11.01.00.9-0.81.0
Short access total infusions0.60.71.30.5-0.7-0.60.4-0.7-0.8-1.0-0.7-0.70.71.00.70.91.21.01.1-1.01.0
Short access day 1 locomotion0.80.81.71.2-1.20.2-0.5-1.1-1.3-1.3-0.9-1.20.20.31.11.11.00.60.7-0.40.5
Short access day 10 total locomotion0.20.20.40.4-0.5-0.10.1-0.5-0.6-0.6-0.7-0.40.10.4-0.10.10.60.40.6-0.40.4
Short access total locomotion0.70.71.40.7-0.8-0.40.3-0.8-0.9-1.0-0.9-0.80.60.90.50.81.20.91.1-0.90.9
One hour access (0.3 mA shock)1.01.23.60.6-0.41.3-1.2-0.2-0.2-0.0-0.5-0.2-1.6-1.4-1.9-1.7-0.9-1.4-1.01.2-1.2
Compulsive drug intake0.40.41.6-0.60.6-1.01.30.40.40.4-0.00.40.60.8-0.8-0.30.40.60.6-0.70.5
One hour access (shock baseline)2.12.44.90.5-0.32.2-2.00.10.10.20.10.1-2.2-2.1-1.4-1.9-1.7-2.1-1.92.0-2.0
Social response proportion0.50.52.21.0-1.30.6-0.7-0.8-0.8-1.5-0.9-0.7-0.5-0.2-0.4-0.10.3-0.00.30.20.0
Social responses0.60.72.51.2-1.40.3-0.5-1.1-1.1-1.6-1.3-1.0-0.40.0-0.5-0.10.80.30.7-0.10.4
Social time0.00.10.4-0.10.1-0.20.30.10.30.00.00.30.00.2-0.6-0.4-0.00.00.1-0.40.1
Soleus weight0.41.02.4-1.51.5-1.31.51.31.31.30.91.10.90.9-0.3-0.2-0.20.50.2-0.90.5
Bone: stiffness0.00.10.1-0.00.10.3-0.20.10.10.10.10.1-0.3-0.3-0.2-0.3-0.3-0.3-0.30.3-0.3
Tibialis anterior weight4.214.530.1-5.55.2-4.14.84.84.74.64.64.74.23.33.11.8-0.72.10.2-2.51.8
Time to tail flick, vehicle, before self-admin1.41.44.31.6-1.51.7-2.1-1.3-1.3-1.3-0.8-1.2-1.2-1.20.60.4-0.1-0.7-0.61.3-0.9
Time to tail flick, vehicle, after self-admin1.11.23.1-1.21.0-1.61.80.90.80.60.60.91.51.50.60.60.51.10.8-1.41.1
Time to tail flick, test, before self-admin1.31.32.51.3-1.3-0.4-0.0-1.6-1.5-1.4-1.4-1.50.40.70.41.01.51.01.3-0.81.0
Time to tail flick, test, after self-admin1.71.83.41.3-1.4-0.80.4-1.6-1.6-1.7-1.8-1.50.61.0-0.10.81.81.21.8-1.31.4
Delta time to tail flick, vehicle, before/after SA1.91.95.3-1.81.7-1.92.31.51.51.31.01.51.51.5-0.2-0.10.10.90.7-1.51.1
Delta time to tail flick, test, before/after SA0.00.00.1-0.0-0.0-0.10.10.10.0-0.1-0.10.1-0.00.0-0.4-0.20.0-0.00.1-0.10.1
Tibia length0.00.00.10.1-0.2-0.20.1-0.3-0.1-0.3-0.2-0.20.20.20.10.20.30.20.3-0.30.3
Ambulatory time before self-admin0.40.40.9-0.90.9-0.20.51.00.91.00.80.90.1-0.0-0.5-0.6-0.6-0.3-0.4-0.0-0.2
Ambulatory time after self-admin0.60.61.4-0.30.3-1.21.00.00.00.10.0-0.01.11.10.81.00.81.00.9-1.01.0
Bone: tissue strength0.20.20.40.6-0.60.5-0.6-0.5-0.5-0.6-0.5-0.6-0.4-0.4-0.1-0.10.1-0.2-0.00.3-0.2
Total heroin consumption1.82.17.41.3-1.41.6-1.5-0.9-0.9-1.1-1.3-0.9-2.1-1.6-2.7-2.1-0.6-1.4-0.71.2-1.2
Bone: trabecular number0.30.40.80.4-0.3-0.60.4-0.6-0.5-0.4-0.5-0.50.60.70.70.90.90.80.9-0.50.8
Bone: trabecular spacing1.21.53.81.8-1.90.9-1.2-1.6-1.6-1.9-1.7-1.8-1.0-0.5-1.0-0.40.7-0.20.50.1-0.0
Bone: trabecular thickness0.40.40.9-0.90.8-0.60.80.80.80.70.90.90.80.60.80.5-0.10.4-0.0-0.10.3
Bone: trabecular tissue density0.91.23.01.7-1.60.4-0.7-1.7-1.7-1.6-1.7-1.5-0.5-0.1-0.70.11.00.20.8-0.40.4
Water consumed over 24 hours0.40.51.40.8-0.70.9-0.8-0.6-0.6-0.5-0.7-0.5-1.0-0.8-1.2-0.9-0.2-0.7-0.30.5-0.6
Number of responses in last shaping day1.31.33.11.4-1.5-0.2-0.2-1.5-1.4-1.7-1.3-1.50.40.60.81.11.41.01.2-1.00.9