Hub : Genes

Hlcs

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression Hlcs 0.07 0.04 1.4e-07 0.06 0.07 0.06 0.07 1.2e-07 5.2e-08 1.8e-07 7.6e-08
2 Liver mRNA stability Hlcs 0.09 0.05 2.8e-11 0.09 0.1 0.09 0.1 1.1e-09 8.6e-11 3.5e-10 8.6e-11
3 pVTA gene expression Hlcs 0.05 0.03 9.9e-04 0.05 0.04 0.05 0.05 1.0e-04 2.5e-04 1.3e-04 1.1e-04
4 BLA mRNA stability Hlcs 0.19 0.1 1.4e-08 0.14 0.11 0.16 0.09 5.0e-08 1.4e-06 7.1e-09 2.2e-05
5 Brain gene expression Hlcs 0.11 0.06 3.6e-10 0.12 0.11 0.11 0.12 2.4e-11 4.5e-10 2.6e-10 5.3e-11
6 Eye gene expression Hlcs 0.37 0.23 9.2e-03 0.06 0.09 0.09 0.09 3.9e-02 1.7e-02 1.8e-02 2.1e-02
7 NAcc gene expression Hlcs 0.05 0.03 9.1e-09 0.06 0.06 0.06 0.01 6.1e-10 2.6e-09 9.9e-09 7.6e-03
8 Liver gene expression Hlcs 0.3 0.12 0.0e+00 0.27 0.28 0.27 0.27 3.1e-30 2.4e-31 7.0e-30 4.0e-30
9 Liver alternative TSS NM_001427025.1 0.03 0.02 3.0e-03 0.01 0.02 0.02 0.02 2.0e-02 2.6e-03 6.0e-03 2.9e-03
10 Liver alternative TSS NM_001427025.1 0.04 0.03 4.9e-04 0.01 0.03 0.03 0.03 6.9e-03 5.3e-04 7.3e-04 7.4e-04
11 IC gene expression Hlcs 0.11 0.07 4.9e-04 0.04 0.03 0.07 0.05 6.9e-03 1.6e-02 5.1e-04 4.8e-03
12 pVTA mRNA stability Hlcs 0.06 0.04 7.5e-04 0.01 0.03 0.02 0.02 2.2e-02 1.5e-03 4.5e-03 5.2e-03
13 NAcc isoform ratio XM_063270413.1 0.03 0.02 1.6e-03 0.01 0.01 0.01 0.01 3.7e-03 2.8e-03 8.7e-03 4.7e-03
14 PL intron excision ratio chr11_47079814_47093804 0.05 0.03 2.3e-03 0.02 0.03 0.01 0.02 3.9e-03 6.1e-04 7.7e-03 1.7e-03
15 Adipose mRNA stability Hlcs 0.16 0.07 2.8e-16 0.09 0.14 0.12 0.13 2.2e-10 4.9e-15 3.7e-13 3.9e-14
16 Brain isoform ratio NM_001427025.1 0.04 0.03 6.1e-03 0.02 0.01 0.01 0.01 1.2e-02 6.8e-02 8.7e-02 1.5e-02
17 Brain mRNA stability Hlcs 0.06 0.05 3.8e-04 0.04 0.02 0.03 0.03 1.3e-04 2.6e-03 7.3e-04 9.5e-04
18 IL isoform ratio XM_063270415.1 0.29 0.16 4.6e-03 0.01 0.02 0.02 0.02 1.5e-01 9.0e-02 1.0e-01 1.1e-01
19 Adipose gene expression Hlcs 0.21 0.09 0.0e+00 0.17 0.22 0.22 0.22 4.5e-19 5.0e-24 5.5e-24 3.5e-24
20 NAcc isoform ratio NM_001427025.1 0.02 0.01 4.1e-03 0.02 0.02 0.01 0.02 2.8e-04 1.6e-03 2.7e-03 6.5e-04
21 NAcc intron excision ratio chr11_47068567_47079680 0.02 0.01 8.5e-03 0.01 0.01 0 0.02 2.0e-03 6.2e-03 7.8e-02 6.2e-04
22 Adipose isoform ratio XM_063270413.1 0.03 0.02 7.2e-03 0 0 -0 0 8.6e-02 1.6e-01 6.2e-01 2.3e-01
23 Adipose isoform ratio XM_063270414.1 0.06 0.03 3.9e-05 0.05 0.04 0.04 0.04 5.5e-06 6.2e-05 8.8e-06 9.9e-06
24 IC alternative TSS XM_063270415.1 0.19 0.11 4.8e-03 0.07 0.04 0.05 0.05 9.2e-04 8.3e-03 4.1e-03 3.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24
Bone: apparent density0.20.41.2-0.20.1-0.2-0.4-0.1-0.0-0.2-0.10.20.2-0.30.71.1-1.10.80.9-0.90.60.80.9-0.9-0.90.90.6
Area under the delay curve1.72.54.20.9-1.0-1.4-1.1-1.41.5-1.3-1.7-1.6-1.5-1.71.61.2-1.32.11.8-1.82.02.01.8-1.8-1.81.8-1.3
BMI with tail0.31.12.5-0.90.80.40.00.3-0.50.40.30.50.6-0.21.61.5-1.41.21.5-1.51.41.11.4-1.4-1.41.40.3
BMI without tail0.21.02.20.1-0.3-0.7-0.9-0.80.4-0.6-0.6-0.3-0.2-1.21.01.4-1.51.41.4-1.41.01.31.3-1.3-1.31.30.2
Body weight0.10.30.50.3-0.4-0.5-0.4-0.60.5-0.5-0.5-0.6-0.6-0.60.60.4-0.40.70.5-0.50.70.70.5-0.6-0.60.6-0.6
Weight adjusted by age0.30.82.01.4-1.4-1.1-1.0-1.41.4-1.3-1.3-1.4-1.4-1.3-0.5-0.40.20.3-0.20.2-0.10.4-0.10.10.1-0.1-0.7
Bone surface1.42.87.3-2.52.72.22.32.4-2.12.41.81.71.71.72.20.7-0.40.41.1-1.11.90.11.1-1.1-1.11.1-0.3
Bone volume0.91.83.9-2.01.91.61.61.6-1.51.61.31.31.41.31.90.9-0.70.61.2-1.21.60.41.1-1.1-1.21.2-0.0
Breakpoint value in progressive ratio session0.20.40.9-0.40.60.70.90.8-0.50.80.60.30.30.5-0.2-0.90.9-0.8-0.60.6-0.2-0.8-0.60.60.6-0.6-0.5
Number of licking bursts0.20.61.40.6-0.9-0.9-1.2-1.10.7-1.1-0.8-0.5-0.4-0.70.21.0-1.10.90.7-0.70.21.00.7-0.8-0.70.70.5
Context. condit. distance diff. score0.40.53.60.7-0.4-0.30.3-0.10.7-0.2-0.6-1.0-1.1-0.4-0.0-1.21.1-0.2-0.50.50.3-0.3-0.40.30.5-0.5-1.9
Locomotion velocity, session 10.20.20.3-0.20.30.30.20.4-0.40.40.40.40.40.5-0.5-0.30.3-0.5-0.50.5-0.6-0.5-0.50.50.5-0.50.6
Locomotion distance, session 10.30.41.2-0.30.70.60.81.1-0.51.10.40.20.10.5-0.2-0.90.9-0.7-0.60.6-0.1-0.9-0.60.60.6-0.6-0.6
Locomotion velocity, session 20.30.30.8-0.10.30.40.50.6-0.30.60.30.10.00.4-0.5-0.90.9-0.7-0.80.8-0.4-0.8-0.70.70.8-0.8-0.4
Locomotion distance, session 20.20.20.70.6-0.4-0.6-0.4-0.30.6-0.3-0.7-0.8-0.8-0.20.40.0-0.10.50.3-0.30.60.40.4-0.4-0.30.3-0.9
Locomotion velocity, session 33.33.88.9-2.22.62.52.73.0-2.62.92.52.22.11.7-0.3-1.21.5-1.9-1.31.3-0.7-2.1-1.31.31.3-1.30.5
Locomotion distance, session 30.30.40.9-0.80.90.50.40.9-0.80.90.50.70.7-0.10.70.7-0.60.30.5-0.50.50.20.6-0.6-0.50.50.6
Stereotopy head waving bouts, day 32.73.210.3-1.71.51.71.11.7-2.31.82.42.72.70.9-1.5-0.10.3-1.9-1.41.4-2.2-1.8-1.41.41.4-1.43.2
Stereotopy head waving duration, day 31.92.46.3-1.61.41.61.21.5-2.01.52.12.32.31.0-1.2-0.20.4-1.6-1.21.2-1.8-1.6-1.11.21.2-1.22.5
Locomotion velocity, session 70.60.71.81.3-1.3-1.2-1.1-0.91.1-1.0-1.1-1.0-1.1-1.0-0.9-0.50.3-0.1-0.50.5-0.7-0.1-0.50.40.5-0.5-0.2
Locomotion distance, session 71.72.25.22.2-1.9-2.3-2.1-1.62.1-1.6-2.3-2.2-2.2-2.2-0.10.2-0.51.10.5-0.50.41.00.5-0.5-0.50.5-1.1
Stereotopy head waving bouts, day 73.74.37.3-2.12.32.62.52.3-2.52.52.72.42.32.5-0.9-1.31.6-2.3-1.71.7-1.4-2.3-1.81.81.7-1.71.2
Stereotopy head waving duration, day 73.54.38.4-1.92.12.62.82.3-2.22.32.52.01.82.9-0.9-1.92.2-2.4-1.91.9-1.2-2.4-1.91.91.9-1.90.1
Locomotion velocity, session 82.32.75.7-1.92.12.32.42.4-2.12.32.11.91.72.0-0.2-1.11.4-1.6-1.11.1-0.5-1.8-1.01.01.1-1.10.2
Locomotion distance, session 80.40.64.60.9-0.4-0.60.1-0.20.9-0.2-1.0-1.3-1.4-0.50.3-0.90.90.2-0.10.10.7-0.0-0.00.00.1-0.1-2.1
Degree of sensitization distance1.41.54.12.0-1.8-1.8-1.6-1.51.8-1.5-1.8-1.9-1.9-1.3-0.7-0.60.30.3-0.30.3-0.30.3-0.30.30.3-0.3-1.1
Degree of sensitization stereotypy2.42.76.6-1.92.22.42.62.1-2.02.22.11.71.62.50.0-1.21.5-1.5-1.01.0-0.3-1.6-1.11.11.0-1.0-0.1
Conditioned locomotion0.30.40.80.9-0.9-0.7-0.6-0.70.7-0.8-0.6-0.7-0.7-0.3-0.9-0.60.5-0.3-0.60.6-0.7-0.3-0.60.60.6-0.6-0.2
Cocaine response after cond. corrected0.71.12.70.30.00.20.50.4-0.00.40.2-0.2-0.31.1-1.1-1.71.6-1.3-1.41.4-0.9-1.3-1.41.41.4-1.4-0.8
Cocaine response after cond. not corrected0.71.02.90.8-0.3-0.20.20.10.40.1-0.3-0.6-0.80.5-1.1-1.71.6-1.1-1.31.3-0.8-1.2-1.41.41.4-1.4-1.1
Cocaine response before conditioning0.30.30.90.6-0.4-0.6-0.4-0.40.6-0.3-0.8-0.8-0.8-0.90.40.1-0.20.60.3-0.30.60.50.4-0.4-0.40.4-0.8
Saline control response0.81.12.6-1.21.51.41.61.6-1.31.61.31.01.01.20.1-0.80.9-1.0-0.70.7-0.1-1.1-0.60.60.6-0.6-0.2
Bone: connectivity density0.50.81.9-1.00.90.50.40.7-0.70.70.40.60.70.11.41.1-1.00.81.2-1.21.20.71.1-1.1-1.21.20.2
Bone: cortical apparent density0.00.00.1-0.1-0.10.00.1-0.20.0-0.20.00.00.0-0.30.10.1-0.10.10.2-0.20.10.20.1-0.1-0.20.2-0.0
Bone: cortical area0.81.33.1-0.40.71.01.41.0-0.61.00.80.40.21.5-0.7-1.71.8-1.4-1.31.3-0.7-1.5-1.31.31.3-1.3-0.9
Bone: cortical porosity0.50.51.30.9-1.0-1.0-0.9-1.11.0-1.1-1.0-0.9-0.9-0.80.00.3-0.40.60.4-0.40.20.70.4-0.4-0.40.4-0.3
Bone: cortical porosity0.40.40.90.9-1.0-0.9-0.9-0.90.9-1.0-0.9-0.9-0.9-0.7-0.20.0-0.10.40.1-0.10.00.40.2-0.2-0.10.1-0.3
Bone: cortical thickness1.52.55.31.5-1.3-0.6-0.2-0.81.0-0.9-0.6-1.1-1.20.3-2.1-2.32.2-1.6-2.12.1-1.8-1.5-2.02.02.1-2.1-1.2
Bone: cortical thickness0.20.20.50.6-0.7-0.5-0.3-0.70.6-0.7-0.5-0.6-0.6-0.4-0.4-0.40.3-0.1-0.30.3-0.30.0-0.30.30.3-0.3-0.5
Bone: cortical tissue density0.00.00.2-0.1-0.10.00.0-0.20.0-0.20.00.10.1-0.40.20.3-0.30.20.3-0.30.20.30.2-0.2-0.30.30.1
Condit. Reinf. active minus inactive responses0.00.00.10.1-0.1-0.1-0.00.00.0-0.0-0.1-0.0-0.10.4-0.1-0.10.1-0.1-0.10.1-0.1-0.1-0.10.10.1-0.1-0.0
Condit. Reinf. active-inactive response ratio0.30.30.60.4-0.3-0.2-0.1-0.10.2-0.1-0.1-0.2-0.20.5-0.8-0.70.6-0.6-0.70.7-0.7-0.6-0.70.70.7-0.7-0.0
Condit. Reinf. active responses0.00.00.20.0-0.0-0.00.10.00.1-0.1-0.1-0.2-0.20.50.2-0.10.10.10.1-0.10.30.00.1-0.1-0.10.1-0.5
Condit. Reinf. inactive responses0.00.00.1-0.20.30.20.30.4-0.30.30.20.20.20.30.1-0.10.2-0.2-0.10.10.0-0.2-0.10.10.1-0.1-0.1
Incentive salience index mean0.10.10.30.5-0.5-0.4-0.3-0.30.5-0.5-0.5-0.5-0.50.1-0.1-0.20.10.1-0.00.00.00.10.0-0.00.0-0.0-0.4
Condit. Reinf. lever presses0.20.30.80.8-0.8-0.6-0.3-0.60.8-0.7-0.7-0.9-0.90.0-0.3-0.60.5-0.0-0.30.3-0.0-0.0-0.20.20.3-0.3-0.9
Condit. Reinf. active minus inactive responses0.20.42.6-0.30.70.51.10.7-0.10.60.1-0.2-0.30.60.7-0.70.8-0.0-0.00.00.9-0.20.1-0.0-0.10.1-1.6
Condit. Reinf. active-inactive response ratio0.50.82.10.3-0.2-0.4-0.2-0.40.7-0.4-0.8-0.8-0.8-0.71.30.5-0.61.21.1-1.11.51.11.1-1.1-1.11.1-1.2
Condit. Reinf. active responses1.01.53.4-1.01.51.41.81.8-1.21.71.20.90.71.4-0.2-1.31.5-1.3-1.11.1-0.2-1.4-1.01.01.0-1.0-0.6
Condit. Reinf. inactive responses1.82.64.4-1.11.61.61.82.1-1.72.01.71.41.31.6-1.0-1.51.7-2.0-1.71.7-1.2-2.1-1.71.71.7-1.70.3
Condit. Reinf. lever presses0.71.02.4-1.11.31.41.61.4-1.11.41.20.90.81.1-0.0-0.91.1-1.0-0.80.8-0.2-1.1-0.70.70.7-0.7-0.3
Condit. Reinf. lever reinforcers received1.01.43.6-1.11.51.41.91.8-1.21.81.20.80.71.3-0.0-1.31.4-1.2-1.01.0-0.1-1.4-0.90.90.9-0.9-0.7
Conditioned reinforcement - actives0.41.64.21.9-1.8-1.9-1.5-1.51.9-1.7-1.9-2.0-2.1-1.0-0.2-0.30.00.80.2-0.20.30.80.2-0.2-0.20.2-1.2
Conditioned reinforcement - inactives1.02.76.22.0-1.7-1.1-0.7-0.81.3-0.8-1.0-1.3-1.5-0.2-2.5-2.22.0-1.5-2.02.0-2.1-1.3-2.12.11.9-1.9-0.4
Conditioned locomotion0.20.30.60.5-0.3-0.2-0.00.10.20.0-0.1-0.2-0.3-0.5-0.8-0.70.6-0.6-0.70.7-0.7-0.5-0.70.70.6-0.60.0
Patch foraging indifference point 0 sec1.23.37.01.1-0.9-0.20.1-0.30.4-0.30.0-0.4-0.50.7-2.7-2.52.4-2.2-2.62.6-2.5-2.1-2.62.62.6-2.6-0.2
Patch foraging indifference point AUC0.61.43.4-1.01.31.51.81.3-1.11.41.30.90.71.8-0.2-1.41.5-1.3-1.11.1-0.3-1.3-0.90.91.0-1.0-0.9
Delay disc. indifference point, 0s delay1.31.53.40.4-0.4-0.7-0.5-0.80.9-0.9-1.1-1.1-1.0-1.11.60.9-0.91.61.5-1.51.81.61.5-1.5-1.51.5-1.2
Delay disc. indifference point, 16s delay0.60.91.60.3-0.4-0.8-0.8-0.70.6-0.6-0.8-0.5-0.5-1.20.91.1-1.21.31.2-1.21.01.31.2-1.2-1.21.20.2
Delay disc. indifference point, 2s delay1.51.73.10.3-0.4-0.8-0.7-0.90.8-0.8-1.0-0.8-0.7-1.11.61.3-1.31.81.7-1.71.71.71.7-1.7-1.71.7-0.8
Delay disc. indifference point, 24s delay0.71.22.51.3-1.3-1.4-1.1-1.31.5-1.3-1.5-1.6-1.6-1.50.40.1-0.31.00.6-0.60.71.00.6-0.6-0.60.6-1.2
Delay disc. indifference point, 4s delay1.61.73.50.5-0.6-0.9-0.7-1.01.1-1.0-1.2-1.2-1.1-1.01.61.0-1.11.81.6-1.61.91.71.6-1.6-1.61.6-1.0
Delay disc. indifference point, 8s delay0.81.32.71.2-1.2-1.3-1.0-1.41.5-1.3-1.6-1.6-1.6-1.40.70.2-0.41.20.8-0.81.01.20.8-0.8-0.80.8-1.5
Indifference point function ln k0.30.82.11.3-1.4-1.2-1.1-1.41.3-1.5-1.2-1.2-1.2-0.6-0.20.0-0.20.60.2-0.20.10.60.1-0.2-0.10.1-0.4
Indifference point function log k0.30.82.11.3-1.4-1.2-1.1-1.41.3-1.5-1.2-1.2-1.2-0.6-0.20.0-0.20.60.2-0.20.10.60.1-0.2-0.10.1-0.4
Patch foraging total patch changes 0 sec1.03.06.60.9-0.6-0.00.3-0.10.3-0.10.1-0.3-0.40.9-2.5-2.52.4-2.2-2.62.6-2.3-2.1-2.52.52.5-2.5-0.3
Patch foraging total patch changes 12 sec2.33.15.0-1.11.31.82.01.6-1.51.61.81.41.32.1-1.3-1.92.1-2.2-2.02.0-1.5-2.2-1.91.91.9-1.90.0
Patch foraging total patch changes 18 sec0.92.14.3-0.60.91.31.61.2-1.01.21.20.80.61.6-1.1-2.02.1-1.9-1.81.8-1.2-1.9-1.71.71.8-1.8-0.6
Patch foraging total patch changes 24 sec0.30.92.7-0.40.70.91.50.8-0.50.80.60.20.11.2-0.3-1.51.6-1.1-1.21.2-0.2-1.1-0.90.90.9-0.9-1.2
Patch foraging total patch changes 6 sec3.05.09.1-0.71.11.61.81.8-1.51.81.81.31.22.2-2.3-2.62.7-3.0-2.92.9-2.5-3.0-2.82.82.8-2.80.4
Patch foraging time to switch 0 sec0.20.92.40.1-0.2-0.7-1.1-0.30.3-0.3-0.6-0.2-0.1-1.20.91.5-1.61.21.2-1.20.81.21.2-1.2-1.31.30.7
Patch foraging water rate 0 sec0.72.75.3-1.71.82.12.31.9-1.91.82.11.81.72.3-0.6-1.21.5-1.8-1.31.3-1.0-1.8-1.31.31.3-1.30.5
Patch foraging water rate 12 sec0.41.42.51.6-1.3-1.1-0.6-1.01.2-1.0-1.0-1.3-1.4-0.4-1.5-1.51.4-0.8-1.41.4-1.1-0.7-1.31.31.3-1.3-1.0
Patch foraging water rate 18 sec0.10.30.6-0.70.60.50.50.2-0.40.20.40.50.50.00.80.7-0.60.40.4-0.40.60.50.7-0.7-0.70.70.3
Patch foraging water rate 24 sec0.40.63.10.9-0.7-0.7-0.1-0.81.1-0.8-0.9-1.3-1.4-0.20.1-0.80.70.30.0-0.00.50.2-0.10.10.0-0.0-1.8
Patch foraging water rate 6 sec0.10.20.60.4-0.2-0.20.3-0.10.4-0.1-0.3-0.5-0.6-0.1-0.3-0.80.7-0.3-0.60.6-0.1-0.3-0.40.40.4-0.4-0.7
Seeking ratio, delayed vs. immediate footshock0.91.33.60.2-0.7-0.8-1.4-1.30.5-1.2-0.6-0.10.0-0.80.71.9-1.91.41.3-1.30.61.61.4-1.4-1.41.41.3
Distance traveled before self-admin0.40.81.2-0.70.71.11.01.1-0.91.01.00.80.71.1-0.6-0.90.9-1.1-0.90.9-0.7-1.1-0.90.90.9-0.90.3
Distance traveled after self-admin0.71.32.6-0.0-0.3-0.5-0.8-0.50.4-0.6-0.6-0.3-0.2-1.11.31.6-1.61.61.5-1.51.31.51.5-1.5-1.51.50.1
Extensor digitorum longus weight2.18.221.6-4.64.43.93.53.9-4.13.83.84.04.12.72.61.7-1.1-0.01.3-1.31.6-0.21.4-1.4-1.41.41.8
Bone: elastic displacement0.10.10.60.3-0.6-0.4-0.7-0.50.3-0.6-0.2-0.1-0.0-0.6-0.50.2-0.30.0-0.10.1-0.50.1-0.10.10.1-0.10.8
Bone: elastic work0.20.20.5-0.30.10.40.20.3-0.50.20.50.50.50.1-0.6-0.30.3-0.7-0.60.6-0.7-0.6-0.50.50.6-0.60.6
Bone: endosteal estimation1.33.16.8-2.42.51.71.72.2-1.82.21.41.61.60.82.61.6-1.31.11.8-1.82.20.81.7-1.7-1.81.80.1
Bone: endosteal perimeter0.51.34.1-1.52.01.51.92.0-1.42.01.20.90.81.21.2-0.30.5-0.20.3-0.31.1-0.40.2-0.2-0.30.3-0.9
Epididymis fat weight0.10.63.0-0.61.00.81.50.9-0.40.90.4-0.0-0.11.10.9-0.80.9-0.20.0-0.01.0-0.3-0.0-0.10.0-0.0-1.7
Delta time in closed arm before/after self-admin2.72.65.00.3-0.6-1.2-1.4-1.10.9-1.1-1.1-0.7-0.6-0.71.82.1-2.22.22.1-2.11.82.22.1-2.1-2.12.10.1
Delta time in open arm before/after self-admin0.20.30.6-0.70.70.80.80.7-0.70.70.80.70.70.30.0-0.10.2-0.4-0.20.2-0.1-0.4-0.20.20.2-0.20.1
Diff in mean of infusions in LGA sessions1.52.65.7-1.31.72.02.21.9-1.62.01.81.31.22.4-0.6-1.71.9-1.9-1.51.5-0.8-1.9-1.51.51.5-1.5-0.2
Delay discount exponential model param1.72.23.7-0.91.01.41.11.4-1.51.31.61.51.51.6-1.5-1.11.2-1.9-1.71.7-1.8-1.9-1.71.71.7-1.71.2
Extinction: sum of active levers before priming0.81.23.2-0.20.50.91.30.8-0.50.80.70.20.11.5-0.8-1.71.8-1.4-1.31.3-0.8-1.4-1.31.31.3-1.3-0.8
Active lever presses in extinction session 63.63.67.2-0.30.51.20.91.3-1.11.11.41.21.11.9-2.5-1.92.0-2.6-2.52.5-2.7-2.5-2.52.52.5-2.51.0
Bone: final force0.40.71.4-0.70.91.01.21.1-0.91.10.90.70.61.1-0.2-0.80.9-0.9-0.70.7-0.3-1.0-0.70.70.7-0.7-0.2
Bone: final moment0.50.81.6-0.81.01.11.31.2-0.91.11.00.70.61.2-0.3-1.01.1-1.0-0.80.8-0.3-1.1-0.80.80.8-0.8-0.3
Food consumed during 24 hour testing period0.30.61.40.8-0.7-0.4-0.3-0.40.4-0.4-0.3-0.4-0.50.1-1.2-1.00.9-0.8-1.01.0-1.0-0.7-1.11.01.1-1.1-0.2
Glucose2.64.010.3-3.03.23.13.03.0-2.93.22.82.62.62.51.0-0.20.6-1.1-0.20.20.5-1.2-0.20.20.2-0.20.5
Heart weight0.50.81.8-0.3-0.1-0.1-0.2-0.70.2-0.6-0.2-0.1-0.0-0.11.21.1-1.11.21.3-1.31.21.21.2-1.2-1.21.2-0.3
Delay discount hyperbolic model param1.82.33.8-0.80.91.31.01.3-1.41.31.61.51.41.5-1.6-1.11.2-1.9-1.71.7-1.9-1.9-1.71.71.7-1.71.3
Intermittent access intake day 1-15 change0.20.92.70.6-0.6-0.2-0.2-0.10.2-0.2-0.1-0.1-0.10.7-1.6-1.11.0-1.2-1.41.4-1.6-1.1-1.11.11.4-1.40.5
Intermittent access intake escalation0.10.72.30.6-0.7-0.3-0.3-0.10.2-0.3-0.1-0.0-0.10.6-1.5-0.80.7-1.0-1.21.2-1.5-0.9-0.90.91.2-1.20.7
Intermittent access intake escalation 20.71.22.4-0.00.20.50.70.7-0.50.70.60.40.31.4-1.4-1.31.4-1.5-1.51.5-1.4-1.5-1.31.31.5-1.50.3
Intermitt. access day 1 inactive lever presses0.11.73.92.0-1.9-1.7-1.4-1.41.6-1.5-1.4-1.5-1.5-1.8-1.6-0.90.7-0.4-1.01.0-1.2-0.4-0.90.81.0-1.0-0.4
Intermitt. access day 15 inactive lever presses0.42.35.80.5-0.20.50.90.4-0.00.50.3-0.1-0.30.4-2.0-2.42.4-2.1-2.22.2-1.8-1.9-2.12.12.1-2.1-0.5
Intermitt. access escalation Index0.10.31.50.7-0.7-0.8-0.7-1.00.8-0.9-0.7-0.7-0.7-1.2-0.2-0.0-0.00.20.0-0.0-0.10.30.1-0.10.0-0.0-0.2
Intermittent access day 1 total infusions0.31.02.61.5-1.4-1.2-0.7-1.11.5-1.2-1.3-1.6-1.6-0.9-0.6-0.90.8-0.0-0.40.4-0.20.1-0.60.50.3-0.3-1.2
Intermittent access day 15 total infusions0.82.15.01.9-1.6-1.1-0.8-0.91.3-1.0-1.0-1.3-1.4-0.2-2.2-1.81.6-1.2-1.71.7-1.9-1.0-1.71.71.6-1.6-0.2
Intermittent access terminal intake (last 3 days)1.11.93.61.9-1.6-1.2-0.7-1.01.4-1.0-1.2-1.5-1.6-0.3-1.9-1.81.6-1.0-1.51.5-1.5-0.8-1.51.51.4-1.4-0.6
Intermittent access total infusions1.31.53.31.8-1.6-1.2-0.8-1.01.4-1.1-1.2-1.4-1.5-0.3-1.6-1.51.3-0.8-1.21.2-1.3-0.6-1.21.21.1-1.1-0.6
Intermittent access day 1 locomotion1.22.25.52.4-2.3-2.1-1.6-2.02.3-2.0-2.1-2.3-2.3-1.6-0.8-0.70.40.4-0.30.3-0.20.6-0.30.30.1-0.1-1.3
Intermittent access day 15 total locomotion0.62.26.21.0-0.5-0.00.50.30.40.2-0.1-0.7-0.80.5-1.9-2.52.4-1.8-2.02.0-1.7-1.7-2.22.21.9-1.9-0.8
Intermittent access total locomotion2.53.06.22.3-1.8-1.2-0.6-1.01.6-1.0-1.3-1.8-2.0-0.0-2.3-2.52.2-1.4-2.02.0-1.8-1.2-2.12.11.8-1.8-1.3
Intermittent access standard deviation0.41.93.80.10.20.60.71.0-0.60.90.80.60.51.0-1.9-1.71.6-1.9-1.91.9-2.0-1.9-1.81.81.9-1.90.6
Left kidney weight0.97.617.03.8-3.9-3.8-3.4-4.14.1-4.1-3.9-4.0-4.0-2.8-0.10.1-0.62.00.9-0.90.82.20.8-0.8-0.90.9-2.2
Right kidney weight0.74.912.23.5-3.4-3.1-2.8-3.33.4-3.3-3.1-3.3-3.3-2.1-1.2-0.80.40.7-0.20.2-0.51.0-0.40.50.2-0.2-1.7
Cocaine induced anxiety0.20.51.40.3-0.10.30.40.10.00.10.1-0.1-0.20.6-0.9-1.21.2-0.9-1.11.1-0.8-0.7-1.11.10.8-0.8-0.4
Post-drug Anxiety0.40.51.80.10.40.41.00.6-0.10.60.1-0.3-0.40.3-0.2-1.31.3-0.7-0.80.80.0-0.6-0.80.80.5-0.5-1.3
Baseline Anxiety0.81.32.50.5-0.5-1.1-0.8-0.80.9-0.8-1.1-0.9-0.9-1.51.31.1-1.21.61.5-1.51.51.31.5-1.5-1.21.2-0.5
Tail length0.42.14.32.1-2.0-1.5-1.2-1.71.6-1.6-1.3-1.5-1.6-0.7-2.0-1.51.3-0.8-1.41.4-1.6-0.7-1.51.41.4-1.4-0.7
Length with tail0.20.92.11.4-1.4-1.1-0.6-1.31.3-1.2-1.1-1.4-1.4-0.5-0.8-1.00.9-0.2-0.70.7-0.4-0.1-0.70.60.6-0.6-1.2
Length without tail0.10.41.0-0.30.40.60.90.5-0.30.40.50.20.10.8-0.2-0.91.0-0.7-0.70.7-0.1-0.6-0.70.70.5-0.5-0.6
Times rat made contact with spout3.74.39.43.1-3.0-2.4-2.4-2.42.4-2.4-2.0-2.2-2.2-1.2-2.8-1.71.3-0.9-1.91.9-2.3-0.7-1.91.91.9-1.9-0.4
Lifetime Intake0.60.82.21.5-1.4-1.3-1.1-1.11.3-1.2-1.2-1.2-1.2-0.6-0.9-0.40.30.0-0.40.4-0.60.2-0.40.40.3-0.3-0.2
Liver weight, left1.93.310.22.7-3.1-2.5-2.6-3.12.7-3.2-2.4-2.3-2.3-1.6-1.1-0.1-0.20.7-0.10.1-0.61.0-0.10.10.1-0.1-0.5
Liver weight, right1.32.37.12.1-2.3-2.3-2.7-2.41.9-2.3-1.9-1.5-1.4-2.2-0.80.8-1.10.90.3-0.3-0.61.00.3-0.3-0.30.30.7
Locomotor activity1.93.07.62.8-2.5-2.5-2.1-2.22.5-2.2-2.5-2.6-2.6-2.4-1.0-0.70.40.5-0.50.5-0.30.6-0.30.30.3-0.3-1.5
Locomotor testing distance0.51.23.21.8-1.6-1.4-1.3-1.31.4-1.2-1.3-1.4-1.5-1.0-1.3-0.90.7-0.3-0.90.9-0.9-0.2-0.80.80.8-0.8-0.5
Locomotor testing rearing0.30.92.21.4-1.3-1.3-1.1-1.21.5-1.3-1.5-1.5-1.5-1.2-0.0-0.1-0.10.70.3-0.30.30.70.3-0.3-0.30.3-1.0
Locomotion in novel chamber0.10.20.60.1-0.10.30.2-0.00.00.00.1-0.1-0.1-0.0-0.5-0.70.8-0.6-0.60.6-0.4-0.5-0.60.60.6-0.6-0.4
Locomotion in novel chamber post-restriction0.20.61.5-1.00.70.70.30.4-0.90.40.81.01.10.10.71.1-1.00.40.7-0.70.30.40.7-0.7-0.70.71.2
Fecal boli incidents, locomotor time 10.61.53.30.8-0.9-0.9-0.5-1.21.3-1.2-1.3-1.5-1.5-0.51.40.4-0.51.51.2-1.21.71.41.2-1.2-1.21.2-1.8
Change in fecal boli incidents, locomotor task0.90.92.51.6-1.6-1.5-1.5-1.41.3-1.4-1.2-1.1-1.1-0.7-1.1-0.2-0.00.0-0.40.4-0.90.2-0.40.40.4-0.40.1
Time >=10cm from walls, locomotor time 10.50.71.40.4-0.30.00.2-0.10.1-0.10.1-0.1-0.10.9-1.2-1.11.1-1.0-1.11.1-1.1-0.9-1.11.11.1-1.1-0.1
Bouts of movement, locomotor time 10.10.10.3-0.40.40.50.50.6-0.50.30.50.40.4-0.6-0.1-0.20.3-0.4-0.20.2-0.2-0.4-0.30.20.2-0.20.2
Total resting periods, locomotor time 10.10.10.3-0.20.30.40.40.5-0.30.20.40.20.2-0.4-0.1-0.40.5-0.4-0.30.3-0.2-0.4-0.40.30.3-0.3-0.1
Rest time, locomotor task time 10.91.44.70.3-0.1-0.6-0.1-0.30.8-0.3-1.0-1.2-1.2-0.71.80.5-0.51.51.4-1.42.21.31.4-1.4-1.41.4-2.0
Distance moved, locomotor task time 10.20.75.2-0.3-0.00.2-0.40.1-0.70.10.71.11.20.6-1.20.4-0.4-0.7-0.60.6-1.6-0.5-0.60.60.6-0.62.3
Vertical activity count, locomotor time 10.21.22.4-0.80.71.00.70.8-1.20.91.31.41.41.1-1.2-0.40.5-1.4-1.11.1-1.5-1.3-1.11.11.1-1.11.6
Time >=10cm from walls, locomotor time 20.20.41.1-1.00.80.70.40.5-0.80.50.71.01.10.50.50.9-0.80.20.5-0.50.20.20.5-0.5-0.50.51.0
Bouts of movement, locomotor time 20.20.83.0-1.01.41.21.71.0-0.71.20.80.30.31.11.0-0.70.9-0.20.1-0.11.0-0.30.1-0.1-0.10.1-1.5
Total resting periods, locomotor time 20.10.42.8-0.30.70.61.20.5-0.10.60.2-0.2-0.30.70.6-0.91.0-0.2-0.10.10.8-0.3-0.20.10.1-0.1-1.7
Rest time, locomotor task time 20.40.72.91.0-0.7-0.50.1-0.20.8-0.4-0.7-1.1-1.20.1-0.4-1.41.3-0.4-0.70.7-0.0-0.5-0.70.70.7-0.7-1.7
Distance moved, locomotor task time 20.91.35.3-1.20.70.5-0.30.2-1.00.40.81.41.6-0.30.62.0-1.90.71.1-1.10.10.81.1-1.1-1.11.12.3
Vertical activity count, locomotor time 20.40.91.9-1.31.10.90.50.6-1.10.71.01.31.40.40.91.3-1.20.50.9-0.90.50.50.9-0.9-0.90.91.3
Light reinforcement 10.20.81.9-0.0-0.1-0.3-0.2-0.40.4-0.4-0.6-0.5-0.5-1.11.30.9-0.91.21.1-1.11.41.21.3-1.3-1.21.2-0.8
Light reinforcement 20.92.14.9-2.12.21.82.11.8-1.61.71.41.31.30.92.20.7-0.40.61.2-1.22.00.41.2-1.2-1.21.2-0.6
Bone: marrow area1.33.37.2-2.42.61.81.82.3-1.92.21.51.61.60.92.71.5-1.31.11.8-1.82.30.81.8-1.7-1.81.80.0
Bone: maximum diameter0.71.44.2-1.31.61.62.01.8-1.31.71.41.00.92.00.3-1.01.2-1.0-0.60.60.2-1.1-0.60.60.6-0.6-0.9
Bone: maximum force0.40.81.6-1.01.11.21.21.2-1.21.21.21.11.11.1-0.3-0.50.6-0.9-0.60.6-0.5-1.0-0.60.60.6-0.60.4
Bone: maximum moment0.40.71.5-1.01.01.11.21.2-1.11.11.11.00.91.2-0.2-0.60.7-0.9-0.60.6-0.4-0.9-0.60.60.6-0.60.2
Mean time between licks in bursts0.21.44.21.9-1.8-1.9-2.1-1.51.5-1.5-1.6-1.4-1.4-1.5-1.1-0.1-0.20.2-0.30.3-0.80.3-0.30.30.3-0.30.2
Mean num. licks in bursts0.72.04.10.8-0.5-0.00.10.00.20.00.1-0.3-0.40.4-1.9-2.01.9-1.7-2.02.0-1.8-1.7-2.02.02.0-2.0-0.4
Cd content in liver0.80.92.2-1.31.00.80.30.8-1.10.80.91.31.4-0.00.81.4-1.30.50.9-0.90.40.50.9-0.9-0.90.91.5
Co content in liver0.60.71.90.0-0.1-0.2-0.1-0.50.5-0.5-0.5-0.6-0.5-0.21.30.6-0.61.11.1-1.11.41.11.1-1.1-1.11.1-0.9
Cu content in liver0.10.10.40.4-0.4-0.3-0.1-0.40.3-0.4-0.2-0.2-0.2-0.1-0.6-0.40.4-0.4-0.50.5-0.5-0.3-0.50.50.5-0.5-0.1
Fe content in liver2.02.54.5-0.80.81.41.41.0-1.21.01.61.31.21.9-1.6-1.51.7-2.1-1.91.9-1.9-2.0-1.91.91.9-1.90.8
K content in liver0.30.30.5-0.50.30.30.20.1-0.30.10.20.40.4-0.00.70.7-0.70.50.7-0.70.60.50.7-0.7-0.70.70.2
Mg content in liver0.40.40.9-0.80.50.50.50.2-0.40.20.40.50.60.21.00.8-0.70.60.8-0.80.80.60.9-0.9-0.90.90.1
Mn content in liver0.20.20.9-0.20.30.10.40.20.00.2-0.1-0.2-0.2-0.00.90.1-0.10.50.6-0.60.90.40.6-0.6-0.60.6-0.9
Na content in liver1.71.95.5-2.02.22.12.32.2-1.92.21.81.61.51.60.8-0.40.7-0.7-0.10.10.5-0.9-0.10.10.1-0.1-0.4
Rb content in liver0.40.41.20.6-0.9-0.8-0.8-1.10.8-1.1-0.8-0.7-0.7-0.70.20.4-0.50.70.5-0.50.30.80.5-0.5-0.50.5-0.2
Se content in liver0.50.62.20.2-0.4-0.0-0.2-0.2-0.1-0.20.30.30.30.1-1.4-0.50.5-1.0-1.11.1-1.5-0.8-1.11.11.1-1.10.9
Sr content in liver0.90.81.81.2-1.3-1.3-1.3-1.31.3-1.3-1.3-1.2-1.2-1.1-0.10.1-0.20.60.3-0.30.10.60.2-0.2-0.20.2-0.5
Zn content in liver0.00.00.1-0.10.00.1-0.0-0.0-0.1-0.00.20.20.20.1-0.20.00.0-0.2-0.10.1-0.3-0.1-0.20.20.2-0.20.2
Bone: minimum diameter1.83.49.5-2.83.12.72.73.0-2.73.02.52.42.32.11.30.20.2-0.60.2-0.20.9-0.80.3-0.2-0.20.20.4
Time in familiar zone, hab. session 10.20.21.50.5-0.2-0.4-0.1-0.10.6-0.1-0.6-0.8-0.8-0.50.5-0.30.20.40.3-0.30.70.30.2-0.2-0.30.3-1.2
Time in novel zone, hab. session 10.80.94.6-1.20.80.60.10.5-1.10.61.01.41.50.00.41.5-1.30.30.7-0.7-0.10.40.6-0.6-0.70.72.1
Total zone transitions, hab. session 11.11.54.42.0-1.6-1.7-1.3-1.21.8-1.2-1.8-2.0-2.1-1.4-0.6-0.90.70.2-0.40.4-0.10.1-0.40.40.4-0.4-1.6
Total locomotion distance, hab. session 10.91.23.31.8-1.6-1.7-1.5-1.41.6-1.3-1.6-1.7-1.7-1.5-0.7-0.40.20.3-0.20.2-0.30.3-0.30.30.2-0.2-0.8
Locomotion velocity, hab. session 10.91.33.51.9-1.7-1.7-1.5-1.51.7-1.4-1.6-1.7-1.7-1.5-0.8-0.50.20.3-0.30.3-0.40.3-0.20.20.3-0.3-0.8
Time in familiar zone, hab. session 20.70.82.9-0.10.3-0.10.20.10.30.1-0.5-0.6-0.6-0.31.50.5-0.51.11.1-1.11.71.01.1-1.1-1.11.1-1.3
Time in novel zone, hab. session 20.30.31.9-0.0-0.30.0-0.4-0.2-0.2-0.20.30.50.6-0.1-0.90.2-0.2-0.5-0.50.5-1.1-0.3-0.50.50.5-0.51.4
Total zone transitions, hab. session 21.41.85.41.9-1.4-1.8-1.3-1.11.9-1.1-2.1-2.3-2.3-1.20.4-0.40.11.00.4-0.41.00.80.5-0.5-0.40.4-2.2
Total locomotion distance, hab. session 22.53.27.42.5-2.2-2.5-2.2-2.12.6-2.0-2.7-2.7-2.7-2.20.30.2-0.51.50.8-0.80.91.40.8-0.8-0.80.8-1.8
Locomotion velocity, hab. session 22.33.17.22.5-2.2-2.5-2.2-2.02.5-2.0-2.7-2.7-2.7-2.20.20.1-0.41.40.7-0.70.81.40.7-0.8-0.70.7-1.8
Novel to familiar place preference ratio0.30.32.1-0.0-0.1-0.4-0.7-0.1-0.1-0.1-0.10.30.4-0.90.01.0-1.10.50.5-0.5-0.20.50.4-0.4-0.50.51.4
Novelty place preference0.50.62.5-0.40.1-0.2-0.5-0.0-0.3-0.00.10.50.7-0.90.51.5-1.50.70.9-0.90.20.80.8-0.8-0.90.91.6
Time in novel zone, NPP test0.60.72.3-0.50.3-0.1-0.40.1-0.40.10.20.60.7-0.80.71.5-1.50.81.0-1.00.40.91.0-1.0-1.01.01.5
Total zone transitions, NPP test0.20.42.40.7-0.3-0.4-0.1-0.10.7-0.1-0.7-1.0-1.1-0.3-0.0-0.90.8-0.1-0.30.30.3-0.2-0.20.20.3-0.3-1.5
Total locomotion distance, NPP test0.40.51.70.9-0.8-1.1-1.0-0.70.9-0.7-1.0-0.9-0.9-1.30.10.3-0.40.70.4-0.40.30.60.4-0.4-0.40.4-0.4
Locomotion velocity, NPP test0.40.61.81.2-1.0-1.3-1.2-0.91.1-0.8-1.2-1.1-1.1-1.4-0.10.2-0.40.60.3-0.30.20.60.3-0.3-0.30.3-0.4
Intraocular pressure0.30.51.6-0.70.30.1-0.2-0.3-0.5-0.10.40.80.9-0.60.51.3-1.20.50.7-0.70.20.60.7-0.7-0.70.71.2
Delta distance traveled before/after self-admin4.95.49.81.0-1.3-2.0-1.8-1.91.8-1.9-2.1-1.8-1.6-2.62.42.4-2.63.12.8-2.82.73.02.8-2.8-2.82.8-1.0
Delta ambulatory time before/after self-admin3.35.710.11.2-1.4-2.1-1.9-2.02.0-2.0-2.3-2.0-1.8-2.52.52.3-2.53.22.8-2.82.83.12.8-2.8-2.82.8-1.3
Parametrial fat weight1.94.59.4-2.42.11.20.81.1-1.61.31.21.71.8-0.23.12.9-2.62.02.7-2.72.61.82.7-2.7-2.62.61.0
Pavlov. Cond. lever latency0.10.21.00.0-0.0-0.2-0.4-0.10.1-0.0-0.2-0.00.0-1.00.30.6-0.60.50.5-0.50.30.40.5-0.5-0.50.50.3
Pavlov. Cond. magazine entry latency0.20.20.70.7-0.8-0.7-0.7-0.80.6-0.8-0.6-0.5-0.5-0.0-0.40.0-0.10.1-0.10.1-0.40.2-0.10.10.1-0.10.2
Pavlov. Cond. change in total contacts0.10.10.30.2-0.3-0.10.1-0.40.4-0.5-0.2-0.4-0.40.50.1-0.20.20.10.1-0.10.20.20.1-0.1-0.10.1-0.6
Pavlov. Cond. index score0.00.10.30.3-0.3-0.2-0.2-0.30.2-0.3-0.1-0.2-0.20.6-0.3-0.20.1-0.1-0.20.2-0.3-0.1-0.20.20.2-0.20.1
Pavlov. Cond. latency score0.10.10.20.4-0.4-0.3-0.3-0.40.4-0.5-0.3-0.3-0.30.3-0.3-0.10.1-0.0-0.10.1-0.20.0-0.10.10.1-0.1-0.0
Pavlov. Cond. lever contacts0.30.41.1-0.10.20.40.50.3-0.20.30.40.20.11.1-0.6-0.90.9-0.8-0.80.8-0.6-0.8-0.80.80.8-0.8-0.2
Pavlov. Cond. magazine entry number0.10.10.3-0.20.40.40.50.5-0.30.50.30.10.10.00.1-0.40.5-0.3-0.20.20.1-0.4-0.20.20.2-0.2-0.5
Pavlov. Cond. intertrial magazine entries5.06.012.2-3.12.93.43.22.9-3.33.03.53.33.23.3-0.6-1.01.4-2.4-1.61.6-1.3-2.4-1.41.51.6-1.61.5
Pavlov. Cond. lever-magazine prob. diff.0.00.00.30.1-0.2-0.0-0.1-0.10.1-0.2-0.0-0.0-0.00.6-0.2-0.10.1-0.1-0.10.1-0.2-0.1-0.20.20.1-0.10.1
Pavlov. Cond. response bias0.10.10.40.2-0.3-0.1-0.1-0.20.1-0.2-0.0-0.1-0.10.7-0.5-0.40.4-0.4-0.50.5-0.5-0.3-0.50.50.5-0.50.1
Pavlov. Cond. lever latency0.60.82.81.0-1.2-1.3-1.7-1.20.9-1.2-1.0-0.6-0.5-1.2-0.50.8-1.00.60.4-0.4-0.40.70.3-0.3-0.30.31.0
Pavlov. Cond. magazine entry latency0.20.31.00.3-0.10.10.40.00.20.1-0.1-0.4-0.40.2-0.4-1.01.0-0.5-0.80.8-0.2-0.6-0.60.60.6-0.6-1.0
Pavlov. Cond. change in total contacts0.20.41.4-0.80.91.01.20.8-0.50.80.60.30.30.70.9-0.30.40.00.2-0.20.9-0.10.2-0.2-0.20.2-1.0
Pavlov. Cond. index score0.50.82.1-0.40.60.91.20.8-0.50.80.70.30.20.8-0.4-1.41.4-1.1-1.11.1-0.4-1.1-1.01.01.0-1.0-0.9
Pavlov. Cond. latency score0.30.41.5-0.00.20.50.80.3-0.00.30.2-0.2-0.30.4-0.3-1.21.2-0.7-0.80.8-0.1-0.7-0.70.70.7-0.7-1.1
Pavlov. Cond. lever contacts0.60.83.0-1.21.31.41.71.3-1.01.31.10.70.71.20.6-0.70.9-0.5-0.20.20.5-0.6-0.20.20.2-0.2-0.9
Pavlov. Cond. magazine entry number0.10.10.80.0-0.1-0.1-0.30.0-0.2-0.00.10.30.30.1-0.50.2-0.2-0.2-0.10.1-0.6-0.2-0.20.20.2-0.20.9
Pavlov. Cond. intertrial magazine entries0.20.40.9-0.70.80.70.81.0-0.91.00.80.80.70.6-0.2-0.30.4-0.7-0.50.5-0.4-0.7-0.50.50.5-0.50.4
Pavlov. Cond. lever-magazine prob. diff.0.50.72.1-0.30.50.81.10.6-0.40.60.60.10.00.7-0.4-1.41.4-1.0-1.11.1-0.3-1.0-1.01.01.0-1.0-1.0
Pavlov. Cond. response bias0.60.92.9-1.11.31.41.71.3-1.01.31.10.70.71.10.3-0.91.0-0.7-0.50.50.3-0.8-0.40.50.4-0.4-0.8
Time in closed arm before self-admin0.10.20.8-0.40.50.30.40.2-0.10.20.10.00.0-0.60.90.3-0.20.50.6-0.60.90.40.6-0.6-0.60.6-0.5
Time in closed arm after self-admin7.48.516.30.3-0.7-1.8-2.0-1.61.4-1.7-1.9-1.3-1.0-2.23.63.7-3.84.03.9-3.93.73.93.9-3.9-3.93.9-0.3
Time in open arm before self-admin0.10.10.20.4-0.4-0.5-0.4-0.40.4-0.3-0.4-0.4-0.40.10.10.2-0.30.40.2-0.20.20.30.2-0.2-0.20.2-0.2
Time in open arm after self-admin2.32.54.3-1.01.31.61.91.6-1.41.71.61.21.11.4-1.2-1.81.9-2.1-1.71.7-1.3-2.1-1.71.71.7-1.7-0.1
Bone: periosteal estimation0.61.44.0-1.72.01.71.92.0-1.62.01.51.31.31.50.9-0.10.4-0.40.1-0.10.7-0.60.1-0.1-0.10.1-0.3
Bone: periosteal perimeter0.61.12.6-0.81.31.21.61.6-1.01.51.00.60.51.2-0.0-1.31.4-1.1-0.80.8-0.1-1.2-0.90.90.8-0.8-0.9
Bone: post-yield work0.91.63.2-1.41.41.61.71.5-1.51.51.71.51.41.8-0.4-0.81.0-1.3-0.90.9-0.7-1.3-0.90.90.9-0.90.4
Progressive ratio test 1 active lever presses1.01.74.42.0-2.1-1.9-1.6-1.92.0-2.0-1.9-1.9-1.9-1.4-0.6-0.30.10.5-0.10.1-0.20.7-0.1-0.1-0.00.0-1.0
Progressive ratio test 1 breakpoint1.01.74.11.9-2.0-1.8-1.5-1.92.0-2.0-1.8-1.9-1.9-1.4-0.5-0.30.10.6-0.00.0-0.10.7-0.0-0.1-0.10.1-1.0
Progressive ratio test 1 inactive lever presses0.51.43.21.8-1.7-1.4-1.3-1.31.3-1.4-1.1-1.1-1.2-1.3-1.8-0.80.6-0.6-1.11.1-1.5-0.5-1.00.81.1-1.10.2
Progressive ratio test 2 active lever presses1.31.94.42.0-1.7-1.4-1.1-1.01.4-1.1-1.2-1.3-1.4-0.6-2.1-1.51.2-1.0-1.51.5-1.8-0.8-1.51.41.4-1.4-0.1
Progressive ratio test 2 breakpoint1.41.84.41.9-1.6-1.2-1.0-0.91.3-1.1-1.0-1.2-1.3-0.6-2.1-1.51.3-1.0-1.51.5-1.8-0.8-1.51.41.4-1.4-0.1
Progressive ratio test 2 inactive lever presses1.34.09.81.9-1.3-0.60.0-0.31.1-0.4-0.7-1.3-1.50.4-2.8-3.12.9-2.2-2.72.7-2.4-2.1-2.62.62.6-2.6-1.0
Incentive Sensitization - Responses0.51.43.60.8-0.4-0.2-0.00.30.20.20.0-0.2-0.30.4-1.9-1.61.5-1.5-1.71.7-1.8-1.4-1.71.71.6-1.60.4
Incentive Sensitization - Breakpoint0.71.74.10.8-0.4-0.10.10.40.10.20.1-0.2-0.30.6-2.0-1.81.7-1.7-1.81.8-1.9-1.6-1.91.81.8-1.80.3
Sum of active levers in priming session hrs 5-61.91.84.0-0.40.51.00.91.0-0.90.91.11.00.92.0-1.5-1.31.4-1.8-1.61.6-1.7-1.7-1.61.61.6-1.60.5
Progressive ratio0.20.51.1-0.90.91.00.80.9-1.00.91.01.01.00.5-0.3-0.20.3-0.7-0.50.5-0.6-0.7-0.50.50.5-0.50.8
Food seeking constrained by brief footshock0.40.52.01.2-1.2-1.1-1.4-0.90.9-1.0-0.8-0.7-0.7-0.4-1.0-0.0-0.1-0.0-0.30.3-0.8-0.0-0.40.40.4-0.40.5
Seeking ratio, punishment vs. effort0.30.62.01.2-1.2-1.3-1.4-1.01.0-1.1-1.1-0.9-0.9-1.1-0.40.3-0.40.50.2-0.2-0.30.40.0-0.0-0.00.00.2
Retroperitoneal fat weight0.93.99.7-2.62.31.71.61.5-1.71.51.41.61.70.83.12.1-1.81.62.4-2.42.71.42.4-2.4-2.22.20.0
Reaction time number correct0.10.40.9-0.10.40.40.70.4-0.20.40.40.10.00.7-0.3-0.90.9-0.7-0.80.8-0.3-0.8-0.70.70.7-0.7-0.5
Reaction time mean minus median0.10.61.40.4-0.50.10.1-0.20.1-0.30.1-0.1-0.20.2-1.2-1.01.0-1.0-1.01.0-1.1-0.9-1.11.11.1-1.1-0.1
Reaction time mean minus median AUC0.21.22.7-0.20.20.91.00.5-0.50.40.80.40.30.9-1.1-1.61.6-1.5-1.31.3-1.1-1.5-1.51.51.5-1.5-0.3
Reaction time num false alarms0.81.44.11.8-1.8-1.7-1.9-1.31.3-1.4-1.4-1.1-1.1-2.0-1.6-0.2-0.1-0.2-0.90.9-1.40.0-0.50.50.6-0.60.6
Reaction time num false alarms AUC0.81.95.62.1-2.1-2.1-2.2-1.71.8-1.8-1.9-1.6-1.5-2.4-1.20.1-0.40.3-0.50.5-0.90.5-0.10.10.2-0.20.3
Reaction time trials correct on left0.10.40.9-0.10.40.40.70.4-0.20.40.40.10.00.7-0.3-0.90.9-0.7-0.80.8-0.3-0.8-0.70.70.7-0.7-0.5
Reaction time trials on left0.10.40.9-0.10.40.40.70.5-0.30.50.40.10.00.7-0.3-0.91.0-0.7-0.80.8-0.3-0.8-0.80.80.7-0.7-0.5
Reaction time mean0.20.32.0-0.60.20.4-0.30.1-0.60.10.50.80.9-0.30.11.0-0.90.20.5-0.5-0.20.30.3-0.3-0.40.41.4
Reaction time mean AUC0.10.21.6-0.50.20.5-0.10.2-0.60.20.60.80.8-0.1-0.40.4-0.3-0.3-0.00.0-0.6-0.3-0.20.20.2-0.21.2
Median of all reaction times0.60.92.9-0.90.40.4-0.40.1-0.70.10.51.01.1-0.50.71.7-1.60.81.2-1.20.30.81.0-1.0-1.01.01.6
Reaction time omissions0.10.21.50.2-0.2-0.4-0.5-0.00.2-0.1-0.3-0.2-0.2-1.20.20.4-0.50.40.4-0.40.20.30.3-0.3-0.30.30.3
Reaction time false alarm rate1.31.85.41.9-2.0-2.0-2.3-1.81.7-1.8-1.8-1.4-1.3-2.3-1.00.5-0.80.6-0.10.1-0.70.80.2-0.2-0.10.10.6
Reaction time premature initiation rate0.50.82.2-1.10.90.70.90.5-0.60.40.50.50.50.61.50.7-0.50.71.0-1.01.40.71.1-1.1-1.11.1-0.4
Reaction time premature initiations0.10.41.8-1.01.00.91.30.8-0.70.70.70.50.51.00.8-0.20.4-0.10.2-0.20.8-0.10.2-0.2-0.20.2-0.7
Std. dev. reaction times0.10.41.30.5-0.6-0.2-0.4-0.30.2-0.4-0.0-0.0-0.0-0.4-1.1-0.50.4-0.7-0.70.7-1.1-0.6-0.80.80.8-0.80.6
Reaction time trials completed0.10.40.9-0.10.40.40.70.5-0.30.50.40.10.00.7-0.3-0.91.0-0.7-0.80.8-0.3-0.8-0.80.80.7-0.7-0.5
Reaction time trials AUC0.10.40.8-0.40.60.60.90.7-0.50.70.60.40.30.8-0.2-0.80.9-0.7-0.70.7-0.3-0.9-0.70.70.7-0.7-0.3
Run reversals in cocaine runway, females0.20.31.00.7-0.7-0.4-0.3-0.70.7-0.7-0.5-0.7-0.7-1.0-0.4-0.50.4-0.1-0.20.2-0.2-0.0-0.20.20.3-0.3-0.6
Run reversals in cocaine runway, males0.50.51.90.10.10.40.90.30.00.20.0-0.3-0.40.5-0.5-1.41.4-0.9-1.11.1-0.3-0.7-0.70.70.7-0.7-1.2
Latency to leave start box in cocaine runway0.40.51.00.2-0.4-0.4-0.5-0.70.5-0.7-0.6-0.5-0.40.30.80.8-0.81.00.9-0.90.91.00.9-0.9-0.90.9-0.4
Latency to leave start box in cocaine runway, F1.01.22.40.5-0.8-1.1-1.4-1.10.8-1.1-1.0-0.7-0.6-0.70.91.5-1.61.51.2-1.20.91.41.2-1.2-1.21.20.1
Latency to leave start box in cocaine runway, M0.20.21.4-0.30.30.60.90.2-0.10.20.3-0.0-0.11.20.2-0.70.8-0.3-0.30.30.3-0.3-0.20.20.2-0.2-1.0
Std. dev. time between licks in bursts0.61.12.40.5-0.30.00.20.10.10.10.1-0.1-0.20.2-1.5-1.51.5-1.4-1.61.6-1.4-1.4-1.61.61.6-1.6-0.2
Total sessions with >9 infusions0.30.31.10.5-0.8-0.8-1.1-0.70.5-0.9-0.5-0.3-0.2-0.5-0.10.8-0.80.60.5-0.5-0.10.60.3-0.5-0.40.40.7
Short access day 1 total inactive lever presses0.40.83.20.9-0.8-0.6-0.8-0.30.3-0.3-0.2-0.1-0.1-0.7-1.8-0.60.5-1.0-1.11.1-1.8-0.8-1.21.21.0-1.01.0
Short access day 10 total inactive lever presses0.10.51.9-0.60.60.40.20.7-0.90.90.81.01.0-0.5-0.60.1-0.1-0.6-0.50.5-0.9-0.6-0.40.60.4-0.41.4
Short access day 1 total infusions0.30.71.90.4-0.7-0.9-1.4-0.80.5-0.9-0.5-0.10.0-1.10.01.3-1.40.80.7-0.7-0.10.90.5-0.6-0.70.71.2
Short access day 10 total infusions0.50.81.90.4-0.7-1.0-1.2-0.80.6-0.9-0.6-0.3-0.2-1.10.31.3-1.41.00.9-0.90.31.10.8-0.9-1.01.00.9
Short access total infusions0.50.71.60.5-0.8-1.0-1.3-0.90.7-1.0-0.7-0.4-0.3-0.80.21.2-1.21.00.8-0.80.21.10.7-0.8-0.90.90.7
Short access day 1 locomotion0.61.03.41.1-1.4-1.5-1.8-1.21.0-1.3-1.0-0.6-0.5-1.7-0.51.0-1.10.70.4-0.4-0.50.80.2-0.3-0.40.41.0
Short access day 10 total locomotion0.00.20.50.3-0.3-0.5-0.1-0.30.5-0.4-0.5-0.6-0.6-0.30.50.1-0.10.50.4-0.40.60.40.4-0.4-0.40.4-0.7
Short access total locomotion0.20.30.50.6-0.7-0.7-0.6-0.70.7-0.7-0.6-0.6-0.6-0.70.10.3-0.30.50.3-0.30.20.50.2-0.3-0.40.4-0.2
One hour access (0.3 mA shock)1.21.53.61.4-1.0-0.6-0.2-0.40.9-0.3-0.6-1.0-1.10.2-1.6-1.91.7-1.2-1.51.5-1.3-1.1-1.61.61.5-1.5-0.7
Compulsive drug intake0.30.41.1-0.90.80.70.50.5-0.60.50.50.50.50.91.00.5-0.40.40.7-0.70.90.30.6-0.6-0.50.5-0.2
One hour access (shock baseline)0.92.56.31.4-1.1-0.6-0.2-0.20.7-0.3-0.4-0.7-0.90.0-2.5-2.22.0-1.8-2.12.1-2.3-1.6-2.22.22.0-2.0-0.1
Social response proportion0.30.41.70.8-1.1-0.7-0.6-1.30.9-1.3-0.7-0.8-0.8-0.6-0.4-0.10.10.2-0.40.4-0.20.4-0.10.10.0-0.0-0.3
Social responses0.70.92.31.2-1.4-1.2-1.0-1.51.4-1.5-1.3-1.4-1.3-0.80.0-0.0-0.10.70.1-0.10.30.80.2-0.2-0.30.3-0.9
Social time0.00.10.3-0.20.20.40.40.0-0.00.10.1-0.1-0.10.50.2-0.30.4-0.10.1-0.10.3-0.1-0.10.10.0-0.0-0.6
Soleus weight0.31.02.7-1.41.61.31.61.5-1.11.41.00.80.80.71.30.00.20.10.5-0.51.2-0.10.5-0.5-0.50.5-0.7
Bone: stiffness0.20.30.7-0.20.30.50.50.4-0.40.50.40.30.30.8-0.5-0.60.7-0.7-0.70.7-0.6-0.7-0.60.60.7-0.7-0.1
Tibialis anterior weight3.712.933.5-5.85.44.94.24.8-5.14.74.75.05.13.23.22.4-1.70.11.8-1.82.0-0.11.8-1.8-1.81.82.5
Time to tail flick, vehicle, before self-admin0.91.14.60.4-0.5-0.3-0.7-0.4-0.1-0.10.30.50.50.4-2.0-0.50.4-1.2-1.31.3-2.2-1.1-1.31.31.3-1.31.6
Time to tail flick, vehicle, after self-admin0.40.82.3-1.10.90.70.80.7-0.60.50.50.50.60.41.50.8-0.70.81.1-1.11.40.71.1-1.1-1.11.1-0.2
Time to tail flick, test, before self-admin2.83.26.81.8-1.9-2.3-2.4-2.32.0-2.2-2.2-1.9-1.8-2.60.71.4-1.72.01.5-1.51.02.01.5-1.5-1.51.5-0.7
Time to tail flick, test, after self-admin2.02.13.61.3-1.3-1.6-1.4-1.81.7-1.6-1.8-1.7-1.7-1.91.00.8-0.91.71.3-1.31.41.71.3-1.3-1.31.3-1.3
Delta time to tail flick, vehicle, before/after SA0.91.03.8-1.00.90.81.10.7-0.40.40.30.10.10.11.90.5-0.30.91.2-1.21.90.81.2-1.2-1.21.2-1.2
Delta time to tail flick, test, before/after SA0.10.10.5-0.20.20.50.50.2-0.20.30.30.10.00.7-0.1-0.60.6-0.4-0.30.3-0.0-0.4-0.30.30.3-0.3-0.3
Tibia length0.00.00.10.1-0.2-0.0-0.1-0.20.1-0.3-0.1-0.1-0.10.10.10.1-0.10.10.1-0.10.10.10.0-0.0-0.10.1-0.1
Ambulatory time before self-admin0.61.73.0-1.21.41.71.51.7-1.61.71.61.51.41.3-0.7-0.91.1-1.5-1.11.1-1.0-1.5-1.11.21.1-1.10.7
Ambulatory time after self-admin0.50.81.7-0.50.30.0-0.20.1-0.20.1-0.10.20.3-0.81.21.3-1.31.11.2-1.21.11.01.2-1.2-1.21.20.2
Bone: tissue strength0.30.30.70.8-0.8-0.8-0.8-0.90.8-0.9-0.8-0.8-0.7-0.8-0.10.1-0.20.40.2-0.20.10.40.2-0.2-0.20.2-0.3
Total heroin consumption1.01.13.21.1-0.9-0.30.1-0.50.9-0.5-0.6-1.1-1.21.0-1.0-1.81.7-0.9-1.21.2-0.6-0.8-1.21.21.2-1.2-1.7
Bone: trabecular number0.20.40.9-0.20.1-0.2-0.3-0.10.1-0.1-0.2-0.00.0-0.20.80.9-0.90.90.9-0.90.80.80.9-0.9-0.90.90.1
Bone: trabecular spacing1.21.84.52.0-2.1-1.8-1.5-2.12.1-2.1-1.9-2.0-2.0-1.3-0.6-0.50.30.4-0.20.2-0.20.6-0.20.20.2-0.2-1.3
Bone: trabecular thickness0.50.71.7-1.31.21.00.91.1-1.21.01.11.21.21.00.60.5-0.4-0.00.4-0.40.3-0.10.3-0.3-0.40.40.7
Bone: trabecular tissue density0.81.53.31.7-1.6-1.8-1.5-1.61.8-1.6-1.8-1.8-1.8-1.7-0.00.0-0.30.90.4-0.40.40.90.3-0.3-0.40.4-1.1
Water consumed over 24 hours0.30.51.01.0-0.8-0.6-0.5-0.60.7-0.6-0.6-0.8-0.8-0.3-1.0-0.90.8-0.5-0.70.7-0.7-0.5-0.80.80.8-0.8-0.5
Number of responses in last shaping day1.72.25.11.8-1.9-2.0-2.1-2.12.0-2.1-1.9-1.8-1.7-2.20.10.7-0.91.30.8-0.80.41.40.7-0.7-0.80.8-0.6