Dagla

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	intron excision ratio	chr1_206905365_206907042	0.03	0.02	3.8e-03	0.01	0.01	0	0.01	4.6e-02	1.7e-02	2.8e-01	5.0e-02
2	Adipose	isoform ratio	XM_039079770.1	0.09	0.05	2.7e-06	0.04	0.03	0.03	0.04	8.4e-06	4.0e-04	1.2e-04	7.2e-05
3	Adipose	alternative TSS	XM_039079770.1	0.06	0.04	7.8e-05	0.03	0.02	0.02	0.02	1.8e-04	2.7e-03	3.0e-03	1.3e-03
4	Brain	gene expression	Dagla	0.07	0.05	1.1e-04	0.06	0.04	0.05	0.05	5.0e-06	2.5e-04	1.6e-05	9.6e-06
5	Adipose	gene expression	Dagla	0.06	0.04	2.0e-04	0.03	0.02	0.01	0.02	6.0e-04	4.9e-03	7.3e-03	1.2e-03
6	Adipose	mRNA stability	Dagla	0.03	0.02	2.8e-03	0.01	0	0	0	3.1e-02	7.3e-02	2.5e-01	9.7e-02
7	Adipose	alternative TSS	XM_039079770.1	0.03	0.02	7.1e-03	0	0	-0	0	1.6e-01	2.8e-01	5.2e-01	2.6e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.3	0.5	0.8	0.3	0.6	0.6	-0.7	-0.9	-0.9	0.7
Area under the delay curve	0.7	0.7	1.6	0.2	0.5	0.4	-0.6	-1.2	-1.0	1.2
BMI with tail	0.7	2.3	11.1	3.3	1.2	1.2	-1.2	-0.4	-0.4	0.5
BMI without tail	0.4	0.8	3.3	1.8	-0.1	-0.1	0.1	0.9	0.5	-0.9
Body weight	0.6	2.6	16.9	4.1	-0.7	-0.7	0.7	0.3	0.1	-0.2
Weight adjusted by age	1.5	1.7	4.1	2.0	-0.5	-0.4	0.7	1.6	1.5	-1.5
Bone surface	0.4	0.8	1.5	1.2	0.1	0.2	-0.4	-1.1	-1.0	1.1
Bone volume	0.5	0.9	1.8	0.6	0.5	0.6	-0.8	-1.4	-1.3	1.2
Breakpoint value in progressive ratio session	3.2	3.5	4.5	1.5	-2.1	-2.0	1.9	1.9	1.8	-1.9
Number of licking bursts	0.2	0.2	0.6	0.1	0.1	0.1	-0.1	-0.8	-0.6	0.7
Context. condit. distance diff. score	0.1	0.1	0.4	-0.0	0.6	0.5	-0.3	-0.1	-0.4	0.0
Locomotion velocity, session 1	0.5	0.5	1.5	0.3	0.2	0.2	0.0	1.1	1.2	-0.8
Locomotion distance, session 1	0.5	0.6	1.5	1.2	0.2	0.1	0.2	0.9	1.2	-0.6
Locomotion velocity, session 2	0.8	1.0	4.2	2.0	-0.6	-0.6	0.8	0.6	0.7	-0.8
Locomotion distance, session 2	0.6	0.9	1.9	1.0	-0.3	-0.4	0.7	1.1	1.4	-1.0
Locomotion velocity, session 3	1.1	1.3	1.7	1.0	1.3	1.2	-1.0	-1.1	-1.2	1.1
Locomotion distance, session 3	0.2	0.2	0.5	-0.2	0.4	0.3	-0.2	-0.5	-0.7	0.6
Stereotopy head waving bouts, day 3	0.8	1.0	2.0	0.4	1.2	1.2	-1.4	-0.8	-0.5	0.9
Stereotopy head waving duration, day 3	0.3	0.3	0.6	0.4	0.7	0.6	-0.8	-0.5	-0.5	0.5
Locomotion velocity, session 7	0.6	0.6	1.7	0.0	0.4	0.3	-0.4	-1.3	-1.0	1.1
Locomotion distance, session 7	0.3	0.3	0.7	-0.1	0.6	0.5	-0.5	-0.8	-0.6	0.7
Stereotopy head waving bouts, day 7	0.1	0.1	0.4	0.6	0.1	0.0	-0.2	-0.1	-0.1	0.2
Stereotopy head waving duration, day 7	0.4	0.5	2.3	1.5	-0.7	-0.7	0.5	0.2	0.2	-0.2
Locomotion velocity, session 8	0.2	0.3	0.5	-0.1	-0.6	-0.7	0.7	0.3	0.5	-0.6
Locomotion distance, session 8	0.2	0.3	0.8	0.2	0.9	0.7	-0.5	-0.2	-0.2	0.4
Degree of sensitization distance	0.5	0.5	1.0	0.5	1.0	0.9	-1.0	-0.6	-0.1	0.4
Degree of sensitization stereotypy	0.3	0.3	1.2	1.1	-0.5	-0.6	0.4	0.4	0.2	-0.3
Conditioned locomotion	0.2	0.3	0.9	0.9	-0.5	-0.6	0.4	0.2	0.4	-0.2
Cocaine response after cond. corrected	0.3	0.3	0.6	-0.2	0.8	0.7	-0.4	0.6	0.6	-0.6
Cocaine response after cond. not corrected	0.4	0.4	0.9	-0.3	0.9	0.9	-0.8	0.4	0.5	-0.4
Cocaine response before conditioning	0.0	0.0	0.1	-0.0	-0.2	-0.1	-0.2	-0.2	-0.1	0.0
Saline control response	1.4	1.8	2.6	1.6	-1.4	-1.3	1.4	1.0	1.4	-1.2
Bone: connectivity density	0.2	0.3	1.8	1.3	0.1	0.1	-0.3	-0.3	-0.3	0.3
Bone: cortical apparent density	0.7	1.0	1.4	0.7	-1.2	-1.1	1.0	0.9	0.8	-1.1
Bone: cortical area	0.1	0.1	0.4	0.6	-0.2	-0.1	0.1	-0.3	-0.3	0.4
Bone: cortical porosity	0.5	0.5	1.2	-0.0	-0.9	-0.9	1.1	0.6	0.6	-0.4
Bone: cortical porosity	1.0	1.1	2.3	0.3	-1.3	-1.2	1.5	0.9	1.0	-0.7
Bone: cortical thickness	2.5	4.0	5.8	1.6	-2.4	-2.3	2.3	1.8	1.7	-1.7
Bone: cortical thickness	0.8	0.9	1.7	0.3	-1.1	-1.1	1.2	0.8	0.5	-1.3
Bone: cortical tissue density	0.9	1.2	1.7	0.8	-1.3	-1.3	1.2	1.0	0.9	-1.2
Condit. Reinf. active minus inactive responses	0.9	1.0	2.3	1.1	-0.2	-0.3	0.3	1.3	1.5	-1.1
Condit. Reinf. active-inactive response ratio	1.8	2.0	4.7	0.7	-0.7	-0.8	0.8	1.8	2.2	-1.9
Condit. Reinf. active responses	0.4	0.5	1.5	1.2	0.3	0.3	-0.2	0.8	0.9	-0.4
Condit. Reinf. inactive responses	0.9	1.0	1.9	0.2	1.4	1.2	-1.2	-0.6	-0.9	1.0
Incentive salience index mean	0.3	0.3	1.3	1.1	0.2	0.3	-0.2	0.5	0.7	-0.2
Condit. Reinf. lever presses	0.5	0.6	1.0	0.6	0.7	0.8	-0.6	-0.8	-0.8	1.0
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.4	0.3	0.4	-0.6	0.2	0.4	-0.1
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.7	-0.0	0.9	1.0	-1.3	-0.5	-0.6	0.5
Condit. Reinf. active responses	0.0	0.0	0.1	-0.1	0.1	0.2	-0.3	0.0	0.4	0.1
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.5	-0.2	-0.1	0.4	0.1	0.4	-0.1
Condit. Reinf. lever presses	0.1	0.2	1.1	1.0	0.1	0.1	-0.2	-0.3	-0.3	0.2
Condit. Reinf. lever reinforcers received	0.1	0.1	0.4	0.3	-0.2	-0.1	0.1	0.4	0.6	-0.3
Conditioned reinforcement - actives	0.6	0.6	1.9	-1.4	0.9	0.8	-0.8	-0.1	-0.1	0.1
Conditioned reinforcement - inactives	1.3	1.4	2.1	-0.7	1.4	1.5	-1.4	-1.1	-1.1	1.0
Conditioned locomotion	2.1	2.5	3.6	-1.2	1.8	1.6	-1.9	-1.5	-1.5	1.4
Patch foraging indifference point 0 sec	0.2	0.3	0.7	0.8	-0.7	-0.7	0.6	0.0	0.4	0.1
Patch foraging indifference point AUC	0.8	0.9	1.8	1.3	-1.2	-1.1	0.6	0.7	0.7	-0.7
Delay disc. indifference point, 0s delay	1.5	1.6	2.7	0.2	1.5	1.3	-1.6	-1.4	-1.1	1.3
Delay disc. indifference point, 16s delay	0.4	0.4	0.7	0.3	0.6	0.5	-0.4	-0.8	-0.6	0.8
Delay disc. indifference point, 2s delay	2.0	2.2	3.6	-0.4	1.4	1.4	-1.5	-1.9	-1.5	1.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	0.1	-0.0	-0.1	0.0	-0.4	-0.4	0.4
Delay disc. indifference point, 4s delay	0.6	0.6	1.5	0.5	0.3	0.3	-0.4	-1.2	-1.1	1.1
Delay disc. indifference point, 8s delay	0.4	0.5	1.2	-0.4	0.1	-0.0	-0.2	-1.1	-0.8	1.1
Indifference point function ln k	2.6	3.7	6.6	-1.7	2.6	2.5	-1.9	-1.5	-1.5	1.4
Indifference point function log k	2.6	3.7	6.6	-1.7	2.6	2.5	-1.9	-1.5	-1.5	1.4
Patch foraging total patch changes 0 sec	0.3	0.5	0.9	0.7	-0.9	-1.0	0.8	0.3	0.6	-0.2
Patch foraging total patch changes 12 sec	4.1	5.4	7.7	2.8	-2.8	-2.7	2.3	1.8	1.8	-1.7
Patch foraging total patch changes 18 sec	0.6	0.8	1.6	0.6	-1.2	-1.0	0.8	0.7	1.0	-0.5
Patch foraging total patch changes 24 sec	2.2	2.7	9.5	3.1	-1.8	-1.7	1.4	0.6	0.7	-0.5
Patch foraging total patch changes 6 sec	0.3	0.4	1.1	1.0	-0.8	-0.7	0.5	-0.2	-0.3	0.2
Patch foraging time to switch 0 sec	0.3	0.4	0.9	0.8	0.5	0.5	-0.5	-0.7	-0.6	0.9
Patch foraging water rate 0 sec	0.1	0.2	1.2	-1.1	-0.0	0.0	0.1	0.3	0.1	-0.3
Patch foraging water rate 12 sec	0.5	0.7	2.2	-1.5	1.0	1.0	-0.6	-0.2	-0.4	-0.1
Patch foraging water rate 18 sec	0.4	0.6	1.0	-1.0	1.0	0.9	-0.6	-0.5	-0.8	0.5
Patch foraging water rate 24 sec	0.3	0.4	1.8	-1.4	0.8	0.6	-0.1	0.0	-0.4	-0.0
Patch foraging water rate 6 sec	0.2	0.3	1.6	-1.3	0.5	0.5	-0.2	-0.1	-0.2	0.2
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.4	0.3	0.5	0.4	-0.4	-0.7	-0.6	0.6
Distance traveled before self-admin	0.8	0.8	1.9	1.4	-0.8	-1.0	0.9	0.6	0.7	-0.6
Distance traveled after self-admin	0.1	0.1	0.3	0.4	-0.6	-0.2	0.2	0.1	0.1	-0.1
Extensor digitorum longus weight	1.7	6.8	28.4	5.3	-2.1	-2.0	2.0	1.5	1.5	-1.6
Bone: elastic displacement	0.8	0.9	1.5	-0.9	-0.6	-0.6	0.6	1.2	1.1	-1.2
Bone: elastic work	1.5	1.9	2.4	0.7	-1.3	-1.4	1.4	1.5	1.5	-1.5
Bone: endosteal estimation	3.8	8.3	10.2	-1.2	3.2	3.1	-3.1	-3.0	-2.9	3.0
Bone: endosteal perimeter	5.1	10.6	12.3	-1.6	3.4	3.4	-3.5	-3.5	-3.5	3.5
Epididymis fat weight	1.7	3.9	5.7	-0.6	2.0	2.0	-1.9	-2.3	-2.4	2.0
Delta time in closed arm before/after self-admin	1.9	1.8	3.3	1.8	-0.9	-0.9	1.4	1.4	1.4	-1.4
Delta time in open arm before/after self-admin	0.9	0.9	1.5	1.2	-0.9	-1.2	0.9	0.8	0.8	-0.8
Diff in mean of infusions in LGA sessions	3.0	3.4	5.0	1.4	-2.0	-2.2	1.9	1.7	1.7	-1.7
Delay discount exponential model param	0.7	0.7	1.6	-0.1	-0.5	-0.4	0.6	1.3	1.0	-1.3
Extinction: sum of active levers before priming	1.4	1.4	3.3	1.8	-1.0	-1.2	1.3	0.9	0.9	-0.9
Active lever presses in extinction session 6	2.1	2.1	3.6	1.3	-1.6	-1.4	1.9	1.2	1.2	-1.2
Bone: final force	0.2	0.3	2.2	1.5	-0.2	-0.3	0.1	0.1	0.1	-0.0
Bone: final moment	0.2	0.3	2.0	1.4	-0.3	-0.3	0.1	0.2	0.2	-0.1
Food consumed during 24 hour testing period	0.1	0.1	0.6	-0.8	0.2	0.2	0.1	0.4	0.1	-0.1
Glucose	3.0	4.6	6.9	-2.0	2.3	2.4	-2.6	-2.0	-1.4	2.1
Heart weight	0.7	1.0	1.6	-0.7	1.1	1.1	-1.3	-0.9	-0.9	1.1
Delay discount hyperbolic model param	0.8	0.9	1.9	-0.2	-0.6	-0.5	0.7	1.4	1.1	-1.4
Intermittent access intake day 1-15 change	0.3	0.3	1.7	-1.3	0.1	-0.1	0.3	0.1	0.1	-0.1
Intermittent access intake escalation	0.2	0.2	0.9	-0.9	0.0	-0.1	0.3	0.3	0.3	-0.3
Intermittent access intake escalation 2	0.3	0.3	0.8	-0.2	-0.6	-0.5	0.9	0.6	0.5	-0.5
Intermitt. access day 1 inactive lever presses	2.8	3.0	4.7	-0.7	1.9	2.0	-2.2	-1.6	-1.7	1.6
Intermitt. access day 15 inactive lever presses	2.5	2.8	3.5	0.5	1.8	1.8	-1.9	-1.8	-1.8	1.7
Intermitt. access escalation Index	1.7	1.5	2.1	-0.4	1.4	1.5	-0.9	-1.3	-1.3	1.4
Intermittent access day 1 total infusions	5.7	6.6	9.7	-0.2	3.1	2.9	-2.9	-2.6	-2.6	2.5
Intermittent access day 15 total infusions	4.1	4.6	7.4	-1.6	2.7	2.4	-2.1	-2.0	-2.0	2.0
Intermittent access terminal intake (last 3 days)	2.4	2.6	5.3	-0.4	2.3	1.9	-1.6	-1.5	-1.5	1.5
Intermittent access total infusions	3.3	3.7	5.8	-0.5	2.4	2.2	-2.0	-1.9	-1.9	1.9
Intermittent access day 1 locomotion	4.2	4.4	6.1	0.5	2.4	2.3	-2.5	-2.1	-2.2	2.0
Intermittent access day 15 total locomotion	1.7	1.8	3.1	0.4	1.6	1.4	-1.8	-1.3	-1.4	1.2
Intermittent access total locomotion	5.5	6.3	9.1	0.5	2.8	2.7	-3.0	-2.6	-2.6	2.5
Intermittent access standard deviation	0.8	0.8	1.5	-0.8	-0.1	-0.4	0.6	1.2	1.2	-1.2
Left kidney weight	0.6	1.8	3.6	0.4	0.8	0.8	-1.3	-1.7	-1.9	1.7
Right kidney weight	0.3	0.9	1.6	0.6	0.6	0.7	-1.0	-1.1	-1.3	1.3
Cocaine induced anxiety	0.3	0.3	0.6	0.6	-0.0	-0.1	0.3	0.7	0.7	-0.7
Post-drug Anxiety	0.4	0.5	0.8	0.9	-0.2	-0.1	0.4	0.9	0.9	-0.8
Baseline Anxiety	0.7	0.7	1.2	1.0	-1.1	-0.9	0.7	0.7	0.7	-0.7
Tail length	1.1	3.4	4.8	1.4	-2.2	-2.2	2.2	1.6	1.3	-1.9
Length with tail	0.6	2.2	7.5	2.7	-1.6	-1.6	1.6	0.3	0.1	-0.5
Length without tail	0.3	0.7	3.5	1.9	-0.4	-0.3	0.3	-0.7	-0.5	0.6
Times rat made contact with spout	0.8	0.9	1.4	0.3	-0.9	-0.9	1.0	1.1	1.2	-1.0
Lifetime Intake	2.5	2.9	5.1	-0.4	2.3	2.0	-1.8	-1.6	-1.5	1.5
Liver weight, left	0.2	0.3	1.3	-1.1	0.3	0.3	-0.2	-0.4	-0.4	0.7
Liver weight, right	0.2	0.3	0.7	-0.3	0.8	0.8	-0.6	-0.1	0.1	0.7
Locomotor activity	0.2	0.3	1.4	-1.2	-0.1	-0.1	0.1	0.4	0.6	0.0
Locomotor testing distance	0.2	0.3	1.2	-1.1	0.3	0.3	-0.4	0.5	0.7	0.1
Locomotor testing rearing	0.3	0.4	1.5	-1.2	0.5	0.5	-0.4	0.5	0.6	0.0
Locomotion in novel chamber	3.0	3.7	5.5	-1.6	2.4	2.1	-1.8	-1.8	-1.8	2.0
Locomotion in novel chamber post-restriction	0.3	0.4	2.1	-1.5	0.4	0.2	-0.1	0.2	0.2	-0.2
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	-0.2	0.4	0.4	-0.6	0.0	-0.0	-0.1
Change in fecal boli incidents, locomotor task	1.1	1.1	1.5	-0.9	1.1	1.1	-1.2	-0.9	-0.9	1.0
Time >=10cm from walls, locomotor time 1	2.8	2.8	4.0	-1.0	2.0	2.0	-1.8	-1.5	-1.7	1.5
Bouts of movement, locomotor time 1	4.1	4.5	5.8	0.8	-2.3	-2.3	2.4	2.1	2.1	-2.3
Total resting periods, locomotor time 1	2.4	2.6	3.8	0.7	-1.8	-1.9	2.0	1.5	1.5	-1.7
Rest time, locomotor task time 1	0.2	0.3	0.8	-0.9	0.2	0.2	-0.3	-0.5	-0.5	0.5
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.4	0.5	0.6	-0.2	-0.0	-0.1	-0.0
Vertical activity count, locomotor time 1	0.4	0.4	1.3	-1.1	0.7	0.8	-0.5	-0.4	-0.3	0.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.4	-0.6	-0.0	-0.1	-0.2	-0.0	-0.2	0.1
Bouts of movement, locomotor time 2	3.4	3.7	6.2	1.9	-1.3	-1.3	1.5	2.3	2.5	-2.3
Total resting periods, locomotor time 2	2.7	2.9	5.4	1.7	-1.0	-1.0	1.2	2.0	2.3	-2.1
Rest time, locomotor task time 2	0.7	0.8	1.6	-1.2	1.2	1.1	-0.8	-0.5	-0.4	0.5
Distance moved, locomotor task time 2	0.4	0.5	1.1	0.1	-1.0	-0.9	1.0	0.5	0.3	-0.5
Vertical activity count, locomotor time 2	0.9	1.0	1.4	-0.9	-1.2	-1.1	1.1	0.9	0.9	-0.9
Light reinforcement 1	0.1	0.1	0.5	-0.7	-0.1	-0.0	-0.2	0.1	0.3	0.3
Light reinforcement 2	1.8	2.4	3.9	-0.6	1.1	1.1	-1.7	-1.9	-2.0	1.9
Bone: marrow area	3.9	8.5	10.3	-1.4	3.2	3.1	-3.2	-3.1	-3.0	3.1
Bone: maximum diameter	0.5	1.0	1.8	0.3	0.6	0.8	-0.8	-1.3	-1.3	1.4
Bone: maximum force	0.5	0.9	3.4	1.9	0.5	0.4	-0.6	-0.9	-0.9	0.8
Bone: maximum moment	0.5	0.8	3.1	1.8	0.4	0.4	-0.5	-0.8	-0.8	0.7
Mean time between licks in bursts	0.9	1.3	1.7	1.1	-0.7	-0.7	1.3	1.3	1.3	-1.3
Mean num. licks in bursts	1.0	1.2	2.3	-0.2	-0.6	-0.6	0.8	1.5	1.5	-1.5
Cd content in liver	0.5	0.6	1.8	-1.3	0.8	0.9	-0.7	-0.3	0.1	0.6
Co content in liver	0.8	0.9	2.9	-1.7	-0.4	-0.4	0.6	0.9	0.8	-1.3
Cu content in liver	0.3	0.3	0.6	0.5	-0.8	-0.7	0.6	0.5	0.2	-0.5
Fe content in liver	0.0	0.0	0.2	0.2	-0.0	0.1	-0.0	0.4	0.0	-0.0
K content in liver	0.7	0.7	1.6	0.9	0.4	0.5	-0.4	-1.0	-0.8	1.3
Mg content in liver	0.8	0.8	1.5	0.6	1.1	1.1	-0.8	-0.8	-0.5	1.2
Mn content in liver	0.4	0.5	1.8	1.3	-0.7	-0.6	0.8	-0.3	-0.1	0.2
Na content in liver	0.1	0.1	0.3	0.5	0.0	0.0	-0.0	0.3	0.5	-0.1
Rb content in liver	1.0	1.2	1.9	-1.3	1.4	1.4	-1.0	-0.8	-0.9	0.8
Se content in liver	0.2	0.2	0.8	0.9	-0.0	0.0	-0.1	-0.7	-0.5	0.4
Sr content in liver	4.7	4.3	6.8	2.6	-1.8	-1.8	1.9	2.2	2.1	-2.0
Zn content in liver	2.2	2.4	5.4	2.3	-1.1	-1.0	1.2	1.7	1.6	-1.4
Bone: minimum diameter	3.2	6.0	7.7	-0.9	2.6	2.6	-2.8	-2.5	-2.4	2.8
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.2	0.4	0.3	-0.3	-0.3	-0.0	0.4
Time in novel zone, hab. session 1	0.3	0.3	1.5	-1.2	0.5	0.3	-0.2	0.2	-0.1	-0.2
Total zone transitions, hab. session 1	0.7	0.9	2.0	0.6	-0.8	-0.9	1.4	0.9	1.0	-0.9
Total locomotion distance, hab. session 1	0.1	0.2	0.6	0.3	0.8	0.8	-0.4	-0.1	-0.1	-0.1
Locomotion velocity, hab. session 1	0.2	0.2	0.6	0.8	0.1	0.1	0.3	0.4	0.5	-0.6
Time in familiar zone, hab. session 2	0.2	0.2	1.2	-1.1	0.0	-0.0	0.0	-0.1	0.3	-0.3
Time in novel zone, hab. session 2	0.2	0.2	1.0	1.0	0.1	0.1	-0.1	0.5	0.1	-0.1
Total zone transitions, hab. session 2	0.5	0.7	1.5	1.0	-0.2	-0.3	0.8	0.9	1.2	-0.8
Total locomotion distance, hab. session 2	0.2	0.2	0.4	0.5	0.6	0.6	-0.1	0.2	0.6	-0.3
Locomotion velocity, hab. session 2	0.2	0.3	0.7	0.4	0.8	0.8	-0.4	-0.1	0.3	0.0
Novel to familiar place preference ratio	0.6	0.6	2.4	1.5	-0.8	-0.8	0.6	0.2	-0.2	-0.2
Novelty place preference	0.4	0.4	1.5	1.2	-0.7	-0.7	0.4	-0.0	-0.4	-0.1
Time in novel zone, NPP test	0.4	0.4	2.0	1.4	-0.6	-0.7	0.4	0.2	-0.1	-0.3
Total zone transitions, NPP test	1.2	1.7	2.9	1.2	-0.9	-1.1	1.3	1.5	1.7	-1.4
Total locomotion distance, NPP test	0.1	0.2	0.5	0.4	0.0	-0.0	0.2	0.5	0.7	-0.5
Locomotion velocity, NPP test	0.1	0.1	0.3	0.1	-0.2	-0.2	0.4	0.3	0.6	-0.3
Intraocular pressure	0.3	0.4	1.1	-0.2	-0.6	-0.6	0.4	0.7	0.8	-1.0
Delta distance traveled before/after self-admin	0.2	0.2	0.8	-0.9	0.3	0.6	-0.4	-0.1	-0.1	0.1
Delta ambulatory time before/after self-admin	0.2	0.2	1.1	-1.0	0.2	0.5	-0.2	0.1	0.1	-0.1
Parametrial fat weight	4.2	8.2	12.2	-1.4	2.6	2.7	-2.8	-3.5	-3.4	3.2
Pavlov. Cond. lever latency	0.1	0.2	0.6	-0.8	-0.3	-0.3	0.1	0.4	0.2	-0.4
Pavlov. Cond. magazine entry latency	0.2	0.3	1.0	1.0	0.3	0.3	-0.3	-0.7	-0.3	0.4
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.3	0.2	0.2	-0.2	-0.3	-0.0	0.3
Pavlov. Cond. index score	0.0	0.0	0.3	0.5	-0.0	0.0	0.1	-0.2	-0.0	0.0
Pavlov. Cond. latency score	0.1	0.1	0.2	0.3	0.3	0.3	-0.1	-0.4	-0.2	0.3
Pavlov. Cond. lever contacts	0.2	0.2	0.4	0.1	0.4	0.5	-0.3	-0.6	-0.4	0.6
Pavlov. Cond. magazine entry number	0.2	0.2	0.5	-0.7	0.5	0.5	-0.7	-0.1	-0.3	0.3
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.0	-0.1	-0.9	-0.9	0.7	1.0	1.0	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.5	0.7	-0.2	-0.1	0.3	-0.0	0.1	-0.1
Pavlov. Cond. response bias	0.1	0.1	0.5	0.7	-0.1	-0.1	0.2	-0.1	-0.0	-0.0
Pavlov. Cond. lever latency	0.3	0.4	1.1	-1.0	-0.6	-0.7	0.7	0.3	0.4	-0.2
Pavlov. Cond. magazine entry latency	2.1	2.4	6.6	2.6	-1.1	-1.0	1.0	1.6	1.3	-1.7
Pavlov. Cond. change in total contacts	0.3	0.4	2.0	1.4	-0.0	0.0	-0.1	0.5	0.3	-0.4
Pavlov. Cond. index score	0.6	0.8	4.7	2.2	-0.3	-0.2	0.0	0.7	0.4	-0.7
Pavlov. Cond. latency score	0.5	0.7	4.3	2.1	-0.1	-0.0	-0.2	0.4	0.2	-0.5
Pavlov. Cond. lever contacts	0.2	0.3	0.9	1.0	0.0	0.1	0.0	0.7	0.6	-0.8
Pavlov. Cond. magazine entry number	2.9	3.6	11.4	-3.4	1.4	1.3	-1.2	-1.9	-1.3	1.8
Pavlov. Cond. intertrial magazine entries	0.6	0.8	3.0	-1.7	0.4	0.5	-0.8	-0.9	-0.3	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	5.0	2.2	-0.4	-0.3	0.2	0.8	0.5	-0.9
Pavlov. Cond. response bias	0.6	0.8	3.0	1.7	-0.3	-0.3	0.3	1.0	0.7	-1.0
Time in closed arm before self-admin	0.4	0.5	0.8	-0.2	0.5	0.5	-0.6	-0.9	-0.8	0.9
Time in closed arm after self-admin	0.2	0.2	0.5	-0.4	0.7	0.6	-0.2	-0.3	-0.3	0.3
Time in open arm before self-admin	0.3	0.3	1.3	-1.1	-0.1	0.2	0.2	0.5	0.4	-0.5
Time in open arm after self-admin	1.4	1.5	2.2	-0.2	-1.5	-1.5	1.4	1.2	1.2	-1.2
Bone: periosteal estimation	1.7	3.4	4.6	-0.2	1.8	1.8	-1.9	-2.1	-2.1	2.2
Bone: periosteal perimeter	0.8	1.3	1.8	-0.2	1.1	1.2	-1.3	-1.2	-1.1	1.3
Bone: post-yield work	5.1	7.0	9.4	-0.4	2.7	2.6	-2.7	-3.1	-3.1	2.9
Progressive ratio test 1 active lever presses	1.0	1.1	1.3	-1.1	1.2	0.9	-0.9	-1.1	-1.0	1.0
Progressive ratio test 1 breakpoint	0.8	0.9	1.5	-1.2	1.1	0.7	-0.8	-0.9	-0.8	0.8
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.8	0.9	0.7	0.6	-0.8	-0.5	-0.5	0.4
Progressive ratio test 2 active lever presses	2.2	2.3	3.5	-1.0	1.9	1.6	-1.6	-1.5	-1.5	1.5
Progressive ratio test 2 breakpoint	2.3	2.6	3.4	-1.5	1.8	1.6	-1.6	-1.6	-1.6	1.6
Progressive ratio test 2 inactive lever presses	2.5	2.9	4.4	-0.2	2.1	2.0	-2.0	-1.7	-1.7	1.6
Incentive Sensitization - Responses	0.6	0.6	0.9	0.2	0.8	0.6	-0.7	-0.9	-0.9	0.9
Incentive Sensitization - Breakpoint	1.0	1.0	1.5	0.1	1.1	0.9	-1.0	-1.2	-1.2	1.2
Sum of active levers in priming session hrs 5-6	1.1	1.1	1.6	0.7	-1.2	-1.0	1.3	1.0	1.0	-1.0
Progressive ratio	0.3	0.4	0.7	0.1	0.8	0.8	-0.5	-0.6	-0.6	0.6
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.3	0.1	0.1	-0.3	0.5	0.5	-0.6
Seeking ratio, punishment vs. effort	0.3	0.4	0.7	-0.2	-0.5	-0.5	0.1	0.8	0.8	-0.8
Retroperitoneal fat weight	3.8	12.5	16.4	-2.6	3.2	3.2	-3.4	-4.1	-4.1	4.0
Reaction time number correct	0.4	0.6	1.0	0.5	-0.6	-0.5	0.8	1.0	0.8	-1.0
Reaction time mean minus median	0.7	0.9	1.3	0.6	-1.1	-1.1	0.7	0.9	1.1	-1.0
Reaction time mean minus median AUC	1.5	1.9	2.9	0.2	-1.5	-1.6	1.1	1.4	1.7	-1.7
Reaction time num false alarms	0.2	0.3	0.5	-0.5	-0.7	-0.7	0.6	0.5	0.4	-0.3
Reaction time num false alarms AUC	0.8	1.1	2.0	-0.1	-1.4	-1.4	1.2	0.9	0.9	-0.7
Reaction time trials correct on left	0.4	0.6	1.0	0.5	-0.6	-0.5	0.8	1.0	0.8	-1.0
Reaction time trials on left	0.5	0.7	1.2	0.5	-0.7	-0.6	0.9	1.1	0.9	-1.1
Reaction time mean	0.2	0.3	0.9	0.0	-0.2	-0.3	0.3	0.8	0.9	-0.7
Reaction time mean AUC	0.1	0.2	0.5	-0.2	0.1	-0.0	0.0	0.5	0.7	-0.5
Median of all reaction times	0.1	0.1	0.3	0.3	0.1	0.0	0.1	0.4	0.5	-0.3
Reaction time omissions	0.7	1.0	1.9	0.0	-1.3	-1.4	1.3	0.6	0.8	-0.8
Reaction time false alarm rate	0.1	0.1	0.4	-0.4	-0.6	-0.6	0.3	-0.0	-0.0	0.2
Reaction time premature initiation rate	0.7	0.9	4.8	2.2	-0.4	-0.4	0.4	-0.5	-0.9	0.5
Reaction time premature initiations	1.1	1.5	5.7	2.4	-1.2	-1.1	1.3	0.5	0.1	-0.6
Std. dev. reaction times	0.8	1.1	1.8	-0.3	-1.1	-1.2	0.9	1.1	1.3	-1.2
Reaction time trials completed	0.5	0.7	1.2	0.5	-0.7	-0.6	0.9	1.1	0.9	-1.1
Reaction time trials AUC	0.4	0.5	0.9	0.4	-0.5	-0.4	0.7	1.0	0.9	-0.9
Run reversals in cocaine runway, females	0.5	0.5	0.7	0.8	0.5	0.5	-0.7	-0.8	-0.8	0.8
Run reversals in cocaine runway, males	0.5	0.5	1.6	-1.3	-0.0	-0.1	0.0	-0.6	-0.6	0.9
Latency to leave start box in cocaine runway	3.3	3.5	5.3	-0.5	2.1	1.9	-1.3	-2.3	-2.3	2.1
Latency to leave start box in cocaine runway, F	0.8	0.9	1.3	0.2	0.9	0.9	-0.7	-1.1	-1.1	1.1
Latency to leave start box in cocaine runway, M	3.2	3.0	4.2	-1.9	1.8	1.6	-0.9	-2.1	-2.0	1.7
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.5	0.5	0.5	-0.1	0.1	-0.2	0.2
Total sessions with >9 infusions	2.2	2.5	4.2	-0.6	1.9	1.8	-2.0	-1.5	-1.4	1.4
Short access day 1 total inactive lever presses	1.9	2.1	2.8	-0.6	1.6	1.7	-1.7	-1.5	-1.4	1.4
Short access day 10 total inactive lever presses	0.9	1.0	1.8	-1.3	1.1	1.2	-1.2	-0.5	-0.5	0.6
Short access day 1 total infusions	1.0	1.1	2.6	-0.5	1.6	1.3	-1.1	-0.8	-0.8	0.7
Short access day 10 total infusions	4.4	4.9	8.5	0.2	2.9	2.6	-2.3	-2.2	-2.1	2.1
Short access total infusions	1.6	1.8	3.6	0.0	1.9	1.7	-1.5	-1.2	-1.2	1.1
Short access day 1 locomotion	0.5	0.5	1.0	0.8	1.0	0.7	-0.8	-0.7	-0.6	0.5
Short access day 10 total locomotion	2.0	2.2	3.5	0.7	1.8	1.7	-1.9	-1.3	-1.4	1.2
Short access total locomotion	1.6	1.7	2.7	1.2	1.5	1.2	-1.6	-1.2	-1.2	1.1
One hour access (0.3 mA shock)	3.7	4.3	6.5	-1.7	2.5	2.4	-2.1	-1.9	-1.8	1.9
Compulsive drug intake	3.9	4.0	5.2	0.7	-2.3	-2.0	1.9	2.2	2.2	-2.1
One hour access (shock baseline)	4.8	5.6	7.5	-2.2	2.7	2.5	-2.1	-2.3	-2.3	2.3
Social response proportion	0.2	0.2	0.6	-0.3	0.1	0.1	-0.1	-0.8	-0.7	0.5
Social responses	0.3	0.4	0.9	-0.4	-1.0	-1.0	0.8	0.3	0.4	-0.3
Social time	1.3	1.7	2.5	-0.3	-1.2	-1.1	1.6	1.5	1.5	-1.5
Soleus weight	1.0	3.0	8.7	-2.9	1.7	1.7	-1.6	-1.0	-1.0	1.4
Bone: stiffness	0.3	0.4	0.9	0.7	0.3	0.3	-0.3	-0.9	-0.9	0.6
Tibialis anterior weight	4.4	15.1	35.1	5.9	-3.9	-3.8	3.6	2.9	3.3	-2.9
Time to tail flick, vehicle, before self-admin	0.8	0.8	0.9	0.9	1.0	0.8	-0.9	-0.9	-0.9	0.9
Time to tail flick, vehicle, after self-admin	0.2	0.2	1.1	1.1	0.3	0.2	0.0	0.1	0.1	-0.1
Time to tail flick, test, before self-admin	0.7	0.7	1.1	0.5	0.6	0.7	-0.9	-1.0	-1.0	1.0
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.6	-0.4	-0.3	0.2	0.1	0.0	-0.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	0.1	-0.4	-0.2	0.5	0.6	0.6	-0.6
Delta time to tail flick, test, before/after SA	2.2	2.0	2.5	-0.2	-1.5	-1.6	1.5	1.5	1.5	-1.5
Tibia length	0.2	0.7	3.6	1.9	-0.7	-0.6	0.3	-0.1	-0.3	0.0
Ambulatory time before self-admin	0.7	0.7	1.3	1.2	-0.9	-1.0	0.9	0.6	0.6	-0.6
Ambulatory time after self-admin	0.3	0.4	0.5	0.3	0.3	0.7	-0.7	-0.7	-0.7	0.7
Bone: tissue strength	0.3	0.3	0.7	-0.8	0.5	0.5	-0.4	-0.3	-0.3	0.4
Total heroin consumption	5.4	6.3	7.7	1.9	-2.8	-2.8	2.8	2.4	2.4	-2.4
Bone: trabecular number	0.3	0.5	0.8	0.9	0.4	0.4	-0.7	-0.8	-0.8	0.6
Bone: trabecular spacing	1.0	1.2	2.7	-0.6	-0.5	-0.5	0.9	1.6	1.6	-1.3
Bone: trabecular thickness	0.8	0.9	1.6	-0.7	0.8	0.8	-0.9	-1.2	-1.3	0.9
Bone: trabecular tissue density	0.9	1.3	5.7	-2.4	0.8	0.8	-0.7	-0.7	-0.7	0.8
Water consumed over 24 hours	0.3	0.3	0.8	0.4	-0.7	-0.7	0.9	0.4	-0.0	-0.4
Number of responses in last shaping day	0.2	0.3	0.5	0.3	-0.3	-0.3	0.4	0.6	0.6	-0.7