Dagla

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	isoform ratio	XM_039079770.2	0.1	0.06	3.2e-07	0.05	0.04	0.04	0.04	4.0e-06	2.5e-05	9.5e-06	1.3e-05
2	Brain	gene expression	Dagla	0.06	0.04	1.1e-04	0.05	0.04	0.04	0.05	1.1e-05	2.1e-04	1.8e-04	3.3e-05
3	pVTA	gene expression	Dagla	0.12	0.08	1.0e-05	0.05	0.06	0.05	0.05	4.8e-05	2.3e-05	6.6e-05	1.3e-04
4	Adipose	gene expression	Dagla	0.08	0.05	1.4e-05	0.04	0.02	0.03	0.03	4.0e-05	1.3e-03	2.5e-04	1.6e-04
5	Adipose	alternative TSS	XM_039079770.2	0.08	0.05	8.0e-06	0.04	0.03	0.04	0.04	2.4e-05	1.8e-04	7.9e-05	3.2e-05
6	Adipose	alternative TSS	XM_039079770.2	0.04	0.03	3.1e-03	0.02	0.01	0	0.01	2.4e-03	6.5e-02	1.2e-01	2.5e-02
7	Adipose	intron excision ratio	chr1_216330243_216331920	0.03	0.02	4.7e-03	0	0.01	-0	0	8.3e-02	2.1e-02	5.1e-01	1.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.3	0.5	0.7	0.5	-0.6	0.7	-0.7	0.9	0.9	0.6
Area under the delay curve	0.5	0.8	1.4	0.5	-0.5	0.9	-1.1	1.2	1.2	0.3
BMI with tail	0.8	2.7	13.1	1.4	-1.4	0.8	-0.7	0.6	0.6	3.6
BMI without tail	0.1	0.5	2.8	0.1	-0.4	0.1	0.4	-0.4	-0.4	1.7
Body weight	0.6	2.7	18.5	-0.0	-0.1	-0.0	-0.3	0.0	0.0	4.3
Weight adjusted by age	0.6	1.7	2.4	-0.5	0.7	-1.4	1.5	-1.5	-1.5	1.6
Bone surface	0.6	1.2	2.6	0.1	-0.4	0.7	-1.2	1.4	1.4	1.6
Bone volume	0.6	1.2	1.9	0.5	-0.8	1.0	-1.4	1.4	1.4	0.9
Breakpoint value in progressive ratio session	2.1	3.8	4.8	-2.2	2.0	-2.1	1.9	-1.9	-1.9	1.7
Number of licking bursts	0.1	0.2	0.4	-0.1	-0.4	0.2	-0.6	0.6	0.6	0.2
Context. condit. distance diff. score	0.0	0.0	0.3	0.5	0.1	0.2	-0.1	0.1	0.1	0.0
Locomotion velocity, session 1	0.2	0.2	0.4	0.2	0.2	-0.4	0.6	-0.6	-0.6	0.2
Locomotion distance, session 1	0.4	0.5	1.4	0.1	0.2	-0.6	0.7	-0.7	-0.7	1.2
Locomotion velocity, session 2	0.7	0.8	3.9	-0.6	0.7	-0.7	0.6	-0.4	-0.4	2.0
Locomotion distance, session 2	0.6	0.8	1.1	-0.4	0.6	-1.0	1.0	-1.0	-1.0	1.0
Locomotion velocity, session 3	1.0	1.2	1.7	1.3	-1.1	1.2	-1.1	1.0	1.0	1.0
Locomotion distance, session 3	0.3	0.3	0.5	0.4	-0.2	0.7	-0.7	0.6	0.6	-0.2
Stereotopy head waving bouts, day 3	0.8	1.0	2.1	1.3	-1.5	1.1	-0.9	0.6	0.6	0.3
Stereotopy head waving duration, day 3	0.2	0.2	0.6	0.6	-0.8	0.5	-0.4	0.2	0.2	0.5
Locomotion velocity, session 7	0.5	0.5	1.0	0.2	-0.4	0.7	-1.0	1.0	1.0	0.2
Locomotion distance, session 7	0.2	0.3	0.4	0.4	-0.4	0.6	-0.5	0.6	0.6	0.1
Stereotopy head waving bouts, day 7	0.0	0.0	0.2	0.1	-0.1	0.1	-0.1	-0.0	-0.0	0.5
Stereotopy head waving duration, day 7	0.3	0.3	1.6	-0.6	0.4	-0.3	0.1	-0.2	-0.2	1.3
Locomotion velocity, session 8	0.3	0.3	1.2	-0.7	1.1	-0.4	0.6	-0.3	-0.3	-0.1
Locomotion distance, session 8	0.1	0.2	0.7	0.8	-0.4	0.3	-0.3	0.3	0.3	0.1
Degree of sensitization distance	0.4	0.4	1.0	0.9	-1.0	0.3	-0.3	0.4	0.4	0.8
Degree of sensitization stereotypy	0.2	0.3	1.1	-0.4	0.3	-0.4	0.3	-0.3	-0.3	1.1
Conditioned locomotion	0.2	0.2	0.8	-0.6	0.4	-0.5	0.1	0.0	0.0	0.9
Cocaine response after cond. corrected	0.1	0.2	0.5	0.7	-0.4	-0.2	0.4	-0.4	-0.4	-0.2
Cocaine response after cond. not corrected	0.2	0.2	0.8	0.9	-0.8	-0.1	0.2	-0.2	-0.2	-0.2
Cocaine response before conditioning	0.0	0.0	0.0	-0.2	-0.2	-0.0	-0.1	0.0	0.0	0.0
Saline control response	1.4	1.9	2.9	-1.6	1.7	-1.3	1.1	-1.1	-1.1	1.7
Bone: connectivity density	0.2	0.4	2.3	0.1	-0.3	0.3	-0.1	0.3	0.3	1.5
Bone: cortical apparent density	0.7	1.1	1.3	-1.1	1.1	-1.0	1.2	-1.2	-1.2	0.4
Bone: cortical area	0.1	0.2	0.4	-0.2	0.2	0.2	-0.6	0.4	0.4	0.7
Bone: cortical porosity	0.9	1.0	2.1	-1.3	1.5	-1.2	0.7	-0.7	-0.7	0.0
Bone: cortical porosity	1.0	1.1	2.3	-1.3	1.5	-1.2	0.7	-0.8	-0.8	0.3
Bone: cortical thickness	2.8	4.7	6.9	-2.5	2.6	-2.2	1.8	-2.0	-2.0	1.6
Bone: cortical thickness	0.7	0.9	1.3	-0.9	1.0	-0.7	1.0	-1.1	-1.1	0.2
Bone: cortical tissue density	1.0	1.5	1.9	-1.3	1.3	-1.2	1.4	-1.3	-1.3	0.6
Condit. Reinf. active minus inactive responses	0.9	1.0	1.4	-0.2	0.7	-1.1	1.1	-1.2	-1.2	1.2
Condit. Reinf. active-inactive response ratio	2.0	2.1	3.2	-0.8	1.1	-1.7	1.8	-1.8	-1.8	0.8
Condit. Reinf. active responses	0.3	0.4	1.6	0.4	-0.0	-0.5	0.5	-0.6	-0.6	1.3
Condit. Reinf. inactive responses	0.7	0.9	1.9	1.3	-1.4	1.0	-0.9	0.8	0.8	0.2
Incentive salience index mean	0.2	0.3	1.4	0.3	0.0	-0.2	0.2	-0.4	-0.4	1.2
Condit. Reinf. lever presses	0.4	0.6	0.7	0.7	-0.7	0.8	-0.9	0.8	0.8	0.8
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	0.1	-0.2	-0.3	-0.1	-0.1	-0.1	-0.2
Condit. Reinf. active-inactive response ratio	0.3	0.6	1.4	0.9	-1.2	0.5	-0.7	0.7	0.7	0.1
Condit. Reinf. active responses	0.0	0.0	0.1	-0.2	0.2	-0.4	-0.1	0.1	0.1	0.2
Condit. Reinf. inactive responses	0.1	0.1	0.6	-0.4	0.8	-0.3	0.2	-0.1	-0.1	-0.3
Condit. Reinf. lever presses	0.2	0.3	1.2	0.2	-0.2	0.1	-0.4	0.6	0.6	1.1
Condit. Reinf. lever reinforcers received	0.1	0.2	0.5	-0.4	0.5	-0.7	0.2	-0.1	-0.1	0.5
Conditioned reinforcement - actives	0.0	0.1	0.2	0.2	-0.1	-0.2	0.3	-0.3	-0.3	-0.4
Conditioned reinforcement - inactives	0.3	0.8	1.3	1.1	-1.1	0.8	-0.9	0.9	0.9	0.2
Conditioned locomotion	2.4	3.6	4.6	2.1	-2.2	2.1	-1.9	1.9	1.9	-1.1
Patch foraging indifference point 0 sec	0.1	0.2	0.5	-0.6	0.6	-0.4	-0.1	0.0	0.0	0.7
Patch foraging indifference point AUC	0.4	0.9	1.4	-1.2	0.9	-1.0	0.8	-0.9	-0.9	1.1
Delay disc. indifference point, 0s delay	1.6	1.8	2.8	1.7	-1.7	1.4	-1.3	1.3	1.3	0.1
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	0.4	-0.2	0.4	-0.6	0.6	0.6	0.3
Delay disc. indifference point, 2s delay	2.7	3.0	4.0	1.7	-1.6	1.9	-2.0	2.0	2.0	-0.4
Delay disc. indifference point, 24s delay	0.1	0.1	0.3	0.0	-0.0	0.5	-0.4	0.4	0.4	0.2
Delay disc. indifference point, 4s delay	0.7	0.7	1.3	0.4	-0.3	1.0	-1.1	1.1	1.1	0.6
Delay disc. indifference point, 8s delay	0.3	0.5	1.0	0.1	-0.2	0.7	-0.8	1.0	1.0	-0.5
Indifference point function ln k	1.0	3.1	5.7	2.4	-1.9	1.9	-1.4	1.5	1.5	-1.7
Indifference point function log k	1.0	3.1	5.7	2.4	-1.9	1.9	-1.4	1.5	1.5	-1.7
Patch foraging total patch changes 0 sec	0.1	0.4	0.9	-0.8	0.9	-0.7	0.3	-0.4	-0.4	0.7
Patch foraging total patch changes 12 sec	4.0	5.4	7.4	-2.7	2.4	-2.4	2.1	-2.0	-2.0	2.7
Patch foraging total patch changes 18 sec	0.3	0.8	1.2	-1.1	1.0	-1.1	0.6	-0.9	-0.9	0.7
Patch foraging total patch changes 24 sec	0.7	2.3	8.3	-1.5	1.5	-1.2	0.7	-0.7	-0.7	2.9
Patch foraging total patch changes 6 sec	0.2	0.3	1.1	-0.5	0.7	-0.2	-0.1	0.0	0.0	1.1
Patch foraging time to switch 0 sec	0.1	0.6	0.9	0.5	-0.7	0.6	-0.9	0.8	0.8	0.8
Patch foraging water rate 0 sec	0.1	0.3	1.4	0.0	0.2	0.0	0.5	-0.4	-0.4	-1.2
Patch foraging water rate 12 sec	0.2	0.6	2.6	1.0	-0.4	0.7	-0.1	0.0	0.0	-1.6
Patch foraging water rate 18 sec	0.2	0.4	0.8	0.8	-0.6	0.9	-0.2	0.3	0.3	-0.9
Patch foraging water rate 24 sec	0.3	0.4	2.0	0.6	-0.2	0.4	0.1	-0.1	-0.1	-1.4
Patch foraging water rate 6 sec	0.2	0.3	1.8	0.3	-0.0	0.4	0.1	-0.1	-0.1	-1.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.6	0.4	-0.5	0.5	-0.8	0.8	0.8	0.5
Distance traveled before self-admin	0.2	0.3	2.3	-0.0	0.2	-0.1	0.0	-0.0	-0.0	1.5
Distance traveled after self-admin	0.3	0.5	0.6	-0.8	0.8	-0.8	0.7	-0.7	-0.7	0.7
Extensor digitorum longus weight	1.8	7.2	27.7	-2.1	2.1	-2.1	1.7	-1.8	-1.8	5.3
Bone: elastic displacement	1.0	1.2	2.1	-0.7	0.9	-1.0	1.3	-1.4	-1.4	-0.7
Bone: elastic work	1.6	2.0	2.6	-1.4	1.5	-1.4	1.5	-1.6	-1.6	0.8
Bone: endosteal estimation	3.6	8.9	10.9	3.1	-3.0	3.1	-3.3	3.3	3.3	-1.1
Bone: endosteal perimeter	4.6	11.3	13.8	3.5	-3.4	3.6	-3.7	3.6	3.6	-1.4
Epididymis fat weight	1.7	8.5	10.6	2.9	-3.3	2.9	-3.2	3.2	3.2	-1.1
Delta time in closed arm before/after self-admin	2.1	2.0	2.4	-1.2	1.4	-1.3	1.4	-1.4	-1.4	1.6
Delta time in open arm before/after self-admin	0.7	0.8	1.8	-0.8	0.8	-1.0	0.7	-0.7	-0.7	1.3
Diff in mean of infusions in LGA sessions	1.4	2.6	3.8	-2.0	1.7	-1.7	1.3	-1.3	-1.3	1.8
Delay discount exponential model param	0.6	0.8	1.4	-0.5	0.5	-1.0	1.2	-1.2	-1.2	-0.3
Extinction: sum of active levers before priming	0.7	1.1	3.8	-1.2	1.0	-0.8	0.5	-0.5	-0.5	1.9
Active lever presses in extinction session 6	1.1	1.1	2.1	-1.1	1.3	-1.1	0.7	-0.7	-0.7	1.4
Bone: final force	0.2	0.3	1.6	-0.0	0.4	0.0	-0.3	0.2	0.2	1.3
Bone: final moment	0.2	0.3	1.6	-0.1	0.5	-0.0	-0.2	0.1	0.1	1.3
Food consumed during 24 hour testing period	0.0	0.1	0.6	0.1	-0.1	0.0	0.2	-0.2	-0.2	-0.8
Glucose	3.2	5.1	7.5	2.7	-2.7	2.4	-2.0	2.1	2.1	-1.7
Heart weight	2.2	3.5	5.0	1.9	-2.2	2.0	-2.1	2.0	2.0	-0.1
Delay discount hyperbolic model param	0.9	1.1	1.8	-0.7	0.7	-1.2	1.3	-1.3	-1.3	-0.2
Intermittent access intake day 1-15 change	0.2	0.9	2.1	0.9	-0.7	0.8	-0.8	0.8	0.8	-1.5
Intermittent access intake escalation	0.2	1.0	2.4	1.1	-0.9	0.8	-0.8	0.8	0.8	-1.6
Intermittent access intake escalation 2	0.2	0.4	0.5	0.6	-0.4	0.5	-0.6	0.6	0.6	-0.7
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.7	0.7	-0.9	0.2	-0.0	0.0	0.0	-0.6
Intermitt. access day 15 inactive lever presses	0.4	2.3	2.7	1.6	-1.7	1.4	-1.5	1.5	1.5	1.3
Intermitt. access escalation Index	0.2	0.7	0.9	0.6	-0.5	0.9	-1.0	1.0	1.0	-0.9
Intermittent access day 1 total infusions	2.4	7.2	10.6	3.2	-3.1	2.8	-2.7	2.7	2.7	0.3
Intermittent access day 15 total infusions	3.3	8.2	11.5	3.4	-3.1	2.9	-2.9	2.9	2.9	-1.5
Intermittent access terminal intake (last 3 days)	3.7	6.4	9.7	3.1	-2.8	2.6	-2.6	2.6	2.6	-0.4
Intermittent access total infusions	6.0	7.1	10.1	3.2	-2.9	2.7	-2.8	2.8	2.8	-0.4
Intermittent access day 1 locomotion	1.5	2.8	4.5	2.1	-2.1	1.7	-1.6	1.6	1.6	0.5
Intermittent access day 15 total locomotion	1.0	3.8	6.2	2.4	-2.5	1.9	-1.9	1.9	1.9	0.5
Intermittent access total locomotion	7.6	9.1	13.7	3.7	-3.6	3.1	-3.0	3.0	3.0	0.5
Intermittent access standard deviation	0.0	0.1	0.4	0.5	-0.1	0.0	0.0	-0.0	-0.0	-0.7
Left kidney weight	0.9	6.8	9.5	2.2	-2.9	2.8	-3.1	2.9	2.9	-0.4
Right kidney weight	0.5	3.4	5.4	1.6	-2.3	1.9	-2.2	1.9	1.9	-0.3
Cocaine induced anxiety	0.1	0.4	0.6	-0.5	0.4	-0.7	0.8	-0.7	-0.7	0.1
Post-drug Anxiety	0.1	0.1	0.4	0.1	-0.1	-0.1	0.3	-0.2	-0.2	0.6
Baseline Anxiety	0.1	0.2	0.3	0.3	-0.2	0.5	-0.4	0.4	0.4	0.6
Tail length	0.4	2.3	3.4	-1.8	1.9	-1.4	1.4	-1.5	-1.5	0.7
Length with tail	0.4	1.9	5.3	-1.5	1.6	-1.0	0.7	-0.9	-0.9	2.3
Length without tail	0.4	2.3	9.1	-1.1	1.4	-1.1	0.7	-1.1	-1.1	3.0
Times rat made contact with spout	1.0	1.2	1.7	-1.1	1.0	-1.2	1.3	-1.2	-1.2	0.3
Lifetime Intake	3.9	4.8	7.5	2.7	-2.4	2.3	-2.3	2.3	2.3	-0.2
Liver weight, left	0.2	0.3	1.6	0.5	-0.7	0.3	-0.1	0.0	0.0	-1.3
Liver weight, right	1.4	2.4	3.2	1.8	-1.8	1.5	-1.4	1.4	1.4	-1.6
Locomotor activity	0.2	0.2	1.4	-0.3	0.1	-0.0	0.1	-0.3	-0.3	-1.2
Locomotor testing distance	0.1	0.2	1.3	0.4	-0.4	0.3	-0.0	-0.1	-0.1	-1.1
Locomotor testing rearing	0.1	0.2	1.5	0.4	0.0	0.0	0.2	-0.1	-0.1	-1.2
Locomotion in novel chamber	2.1	2.8	3.3	1.8	-1.5	1.7	-1.8	1.8	1.8	-1.4
Locomotion in novel chamber post-restriction	0.1	0.3	2.1	0.4	-0.4	0.1	0.0	-0.0	-0.0	-1.5
Fecal boli incidents, locomotor time 1	0.0	0.1	0.3	0.1	-0.5	-0.3	-0.0	-0.0	-0.0	-0.2
Change in fecal boli incidents, locomotor task	1.7	1.8	3.0	1.4	-1.3	1.7	-1.2	1.2	1.2	-1.2
Time >=10cm from walls, locomotor time 1	1.8	2.2	3.6	1.9	-1.7	1.3	-1.3	1.5	1.5	-1.0
Bouts of movement, locomotor time 1	4.2	5.5	8.3	-2.4	2.5	-2.9	2.4	-2.4	-2.4	0.8
Total resting periods, locomotor time 1	2.8	3.3	5.2	-1.9	2.0	-2.3	1.8	-1.8	-1.8	0.6
Rest time, locomotor task time 1	0.3	0.5	1.4	0.5	-0.6	0.2	-0.7	0.7	0.7	-1.2
Distance moved, locomotor task time 1	0.0	0.1	0.3	0.5	-0.2	0.5	-0.0	0.0	0.0	0.4
Vertical activity count, locomotor time 1	0.1	0.4	1.1	0.7	-0.4	0.9	-0.4	0.3	0.3	-1.0
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.3	-0.0	-0.2	-0.1	0.1	0.0	0.0	-0.5
Bouts of movement, locomotor time 2	1.1	3.7	5.3	-1.2	1.3	-2.3	2.1	-2.2	-2.2	1.8
Total resting periods, locomotor time 2	0.7	2.9	4.6	-0.9	1.1	-2.2	1.8	-2.0	-2.0	1.6
Rest time, locomotor task time 2	0.3	0.6	1.6	0.9	-0.8	0.3	-0.5	0.5	0.5	-1.3
Distance moved, locomotor task time 2	0.4	0.5	1.1	-0.9	1.1	-0.5	0.6	-0.6	-0.6	0.1
Vertical activity count, locomotor time 2	0.3	0.6	1.0	-0.9	1.0	-0.4	0.7	-0.8	-0.8	-0.8
Light reinforcement 1	0.0	0.1	0.3	0.2	-0.3	0.1	-0.5	0.4	0.4	-0.5
Light reinforcement 2	1.4	3.1	4.3	1.4	-1.9	1.7	-2.1	2.1	2.1	-0.5
Bone: marrow area	3.8	9.3	11.4	3.1	-3.1	3.2	-3.4	3.4	3.4	-1.2
Bone: maximum diameter	0.7	1.5	3.0	0.8	-0.9	1.2	-1.7	1.5	1.5	0.3
Bone: maximum force	0.5	0.9	3.4	0.4	-0.3	0.6	-1.0	0.9	0.9	1.8
Bone: maximum moment	0.4	0.8	3.3	0.3	-0.2	0.5	-0.9	0.7	0.7	1.8
Mean time between licks in bursts	0.1	0.9	1.2	-0.4	0.8	-1.0	1.1	-1.1	-1.1	0.7
Mean num. licks in bursts	0.5	1.4	2.4	-0.6	1.1	-1.1	1.6	-1.5	-1.5	-0.3
Cd content in liver	0.6	0.6	1.0	0.8	-0.7	0.7	-0.8	0.8	0.8	-1.0
Co content in liver	0.6	0.7	1.1	-0.6	0.7	-0.5	0.9	-0.9	-0.9	-1.1
Cu content in liver	0.1	0.1	0.2	-0.4	0.4	-0.1	0.2	-0.4	-0.4	-0.2
Fe content in liver	0.0	0.0	0.1	0.3	-0.1	0.1	0.2	-0.1	-0.1	0.0
K content in liver	0.4	0.4	0.6	0.4	-0.1	0.5	-0.8	0.8	0.8	0.5
Mg content in liver	0.4	0.4	0.7	0.8	-0.6	0.7	-0.8	0.4	0.4	0.0
Mn content in liver	0.8	0.9	3.3	-0.9	1.1	-0.7	0.4	-0.3	-0.3	1.8
Na content in liver	0.0	0.0	0.1	0.2	-0.0	-0.0	0.2	0.1	0.1	0.3
Rb content in liver	0.8	1.0	3.1	1.1	-0.7	0.9	-0.7	0.5	0.5	-1.8
Se content in liver	0.1	0.1	0.3	0.1	-0.1	0.1	-0.2	0.3	0.3	0.5
Sr content in liver	3.3	2.9	4.9	-1.6	1.5	-1.8	1.5	-1.6	-1.6	2.2
Zn content in liver	1.4	1.6	3.4	-1.1	1.0	-1.1	1.0	-1.3	-1.3	1.8
Bone: minimum diameter	3.3	6.3	8.8	2.6	-2.6	2.7	-3.0	2.7	2.7	-0.7
Time in familiar zone, hab. session 1	0.0	0.1	0.1	0.3	0.0	0.1	-0.2	0.3	0.3	0.1
Time in novel zone, hab. session 1	0.3	0.3	1.5	0.6	-0.5	0.4	-0.2	-0.1	-0.1	-1.2
Total zone transitions, hab. session 1	0.6	0.8	1.8	-0.9	1.3	-0.8	0.8	-0.9	-0.9	0.5
Total locomotion distance, hab. session 1	0.1	0.1	0.5	0.7	-0.4	0.3	-0.1	-0.1	-0.1	0.3
Locomotion velocity, hab. session 1	0.2	0.3	0.7	0.0	0.2	-0.3	0.5	-0.7	-0.7	0.8
Time in familiar zone, hab. session 2	0.2	0.2	1.2	0.0	0.3	-0.1	0.1	0.2	0.2	-1.1
Time in novel zone, hab. session 2	0.2	0.2	1.0	0.1	-0.3	0.0	-0.1	-0.4	-0.4	1.0
Total zone transitions, hab. session 2	0.3	0.4	0.9	-0.3	0.7	-0.5	0.3	-0.7	-0.7	1.0
Total locomotion distance, hab. session 2	0.1	0.1	0.3	0.5	-0.2	-0.1	-0.0	-0.3	-0.3	0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.5	0.7	-0.5	0.2	-0.3	-0.0	-0.0	0.4
Novel to familiar place preference ratio	0.4	0.5	2.3	-0.7	0.5	-0.2	0.4	-0.4	-0.4	1.5
Novelty place preference	0.2	0.3	1.4	-0.5	0.3	-0.0	0.2	-0.3	-0.3	1.2
Time in novel zone, NPP test	0.3	0.4	1.9	-0.5	0.3	-0.2	0.4	-0.4	-0.4	1.4
Total zone transitions, NPP test	1.0	1.5	2.0	-1.2	1.4	-1.3	1.1	-1.2	-1.2	1.2
Total locomotion distance, NPP test	0.1	0.2	0.3	-0.2	0.3	-0.3	0.5	-0.6	-0.6	0.4
Locomotion velocity, NPP test	0.1	0.1	0.2	-0.3	0.4	-0.2	0.4	-0.4	-0.4	0.1
Intraocular pressure	0.3	0.5	0.8	-0.6	0.4	-0.9	0.9	-0.8	-0.8	-0.2
Delta distance traveled before/after self-admin	0.5	0.5	0.7	-0.6	0.6	-0.7	0.9	-0.9	-0.9	-0.6
Delta ambulatory time before/after self-admin	0.4	0.6	0.8	-0.6	0.6	-0.7	0.9	-0.9	-0.9	-0.8
Parametrial fat weight	6.4	15.2	21.6	3.0	-3.6	4.1	-4.6	4.6	4.6	-1.6
Pavlov. Cond. lever latency	0.1	0.1	0.6	-0.1	0.2	-0.3	0.2	-0.2	-0.2	-0.7
Pavlov. Cond. magazine entry latency	0.2	0.3	1.1	0.4	-0.1	0.2	-0.4	0.5	0.5	1.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.2	-0.1	0.0	-0.1	0.2	0.2	0.5
Pavlov. Cond. index score	0.1	0.1	0.5	-0.1	0.2	-0.1	0.0	0.0	0.0	0.7
Pavlov. Cond. latency score	0.1	0.1	0.3	0.2	0.0	0.2	-0.2	0.2	0.2	0.5
Pavlov. Cond. lever contacts	0.2	0.2	0.3	0.4	-0.3	0.5	-0.4	0.5	0.5	0.4
Pavlov. Cond. magazine entry number	0.2	0.3	0.8	0.5	-0.7	0.6	-0.2	0.2	0.2	-0.9
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.8	-0.9	0.4	-0.7	0.7	-0.7	-0.7	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.6	-0.1	0.2	-0.2	0.1	-0.0	-0.0	0.7
Pavlov. Cond. response bias	0.1	0.1	0.8	-0.2	0.3	-0.3	0.1	-0.0	-0.0	0.9
Pavlov. Cond. lever latency	0.2	0.2	1.3	-0.5	0.2	0.1	0.0	-0.2	-0.2	-1.2
Pavlov. Cond. magazine entry latency	2.1	3.0	8.1	-1.2	1.2	-1.7	1.6	-1.5	-1.5	2.8
Pavlov. Cond. change in total contacts	0.2	0.4	2.3	0.1	0.1	-0.6	0.2	-0.3	-0.3	1.5
Pavlov. Cond. index score	0.7	1.0	5.3	-0.2	0.2	-0.9	0.7	-0.6	-0.6	2.3
Pavlov. Cond. latency score	0.5	0.9	5.0	-0.1	0.1	-0.7	0.5	-0.4	-0.4	2.2
Pavlov. Cond. lever contacts	0.2	0.2	1.2	0.3	-0.0	-0.4	0.3	-0.2	-0.2	1.1
Pavlov. Cond. magazine entry number	3.5	4.5	12.7	1.5	-1.4	2.1	-1.9	1.8	1.8	-3.6
Pavlov. Cond. intertrial magazine entries	0.4	0.9	2.9	0.3	-0.7	0.7	-0.7	0.9	0.9	-1.7
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.3	5.8	-0.4	0.4	-1.0	0.8	-0.7	-0.7	2.4
Pavlov. Cond. response bias	0.6	0.8	4.0	-0.1	0.3	-0.8	0.6	-0.4	-0.4	2.0
Time in closed arm before self-admin	0.6	1.1	1.6	1.1	-0.9	1.0	-1.3	1.3	1.3	-0.3
Time in closed arm after self-admin	0.3	0.4	0.6	0.8	-0.4	0.6	-0.6	0.6	0.6	-0.8
Time in open arm before self-admin	0.3	0.3	1.3	-0.2	0.3	0.1	0.5	-0.5	-0.5	-1.1
Time in open arm after self-admin	1.1	1.2	1.8	-1.3	1.3	-1.1	1.1	-1.1	-1.1	0.5
Bone: periosteal estimation	1.8	4.2	6.5	1.8	-1.8	2.2	-2.6	2.4	2.4	-0.1
Bone: periosteal perimeter	0.9	1.8	3.1	1.4	-1.3	1.4	-1.8	1.4	1.4	-0.2
Bone: post-yield work	3.8	6.6	8.9	2.5	-2.3	2.9	-3.0	2.9	2.9	-0.1
Progressive ratio test 1 active lever presses	0.4	0.7	1.1	1.1	-0.8	0.9	-0.9	0.9	0.9	-0.1
Progressive ratio test 1 breakpoint	0.4	0.7	1.1	1.0	-0.8	0.9	-0.9	0.9	0.9	-0.1
Progressive ratio test 1 inactive lever presses	0.2	0.5	2.6	0.5	-0.6	0.1	-0.2	0.2	0.2	1.6
Progressive ratio test 2 active lever presses	2.2	3.1	4.4	2.1	-1.9	1.8	-1.9	1.9	1.9	-0.5
Progressive ratio test 2 breakpoint	2.6	3.3	4.7	2.2	-2.0	1.9	-1.9	1.9	1.9	-0.4
Progressive ratio test 2 inactive lever presses	1.0	3.2	4.6	2.1	-2.1	1.8	-1.8	1.8	1.8	-0.1
Incentive Sensitization - Responses	0.4	1.0	1.2	1.1	-1.1	0.9	-1.0	1.0	1.0	0.9
Incentive Sensitization - Breakpoint	0.6	1.5	1.8	1.3	-1.3	1.1	-1.2	1.2	1.2	0.8
Sum of active levers in priming session hrs 5-6	1.2	1.1	1.9	-1.4	1.2	-1.3	0.9	-0.9	-0.9	0.6
Progressive ratio	0.4	1.2	2.2	1.5	-1.1	1.1	-1.1	1.1	1.1	0.2
Food seeking constrained by brief footshock	0.1	0.1	0.3	0.3	-0.6	0.1	0.3	-0.3	-0.3	-0.2
Seeking ratio, punishment vs. effort	0.2	0.5	0.9	-0.7	0.2	-0.6	0.9	-0.9	-0.9	-0.1
Retroperitoneal fat weight	4.2	18.7	22.3	4.0	-4.5	4.5	-4.7	4.6	4.6	-3.3
Reaction time number correct	0.2	0.6	0.9	-0.6	0.8	-0.7	0.8	-0.9	-0.9	0.4
Reaction time mean minus median	0.2	1.3	1.8	-1.2	1.0	-1.3	1.3	-1.2	-1.2	0.7
Reaction time mean minus median AUC	0.4	2.6	3.6	-1.6	1.4	-1.8	1.9	-1.8	-1.8	0.2
Reaction time num false alarms	0.1	0.2	0.4	-0.6	0.6	-0.3	0.2	-0.2	-0.2	-0.6
Reaction time num false alarms AUC	0.3	0.6	1.7	-1.3	1.1	-0.7	0.6	-0.5	-0.5	-0.2
Reaction time trials correct on left	0.2	0.6	0.9	-0.6	0.8	-0.7	0.8	-0.9	-0.9	0.4
Reaction time trials on left	0.2	0.7	1.0	-0.7	0.9	-0.8	0.9	-1.0	-1.0	0.4
Reaction time mean	0.2	0.5	0.9	-0.3	0.5	-0.9	0.9	-0.9	-0.9	0.1
Reaction time mean AUC	0.1	0.3	0.6	0.0	0.3	-0.6	0.8	-0.7	-0.7	-0.2
Median of all reaction times	0.1	0.1	0.2	0.1	0.3	-0.5	0.5	-0.5	-0.5	0.1
Reaction time omissions	0.7	1.1	2.1	-1.3	1.4	-1.2	1.0	-0.8	-0.8	0.4
Reaction time false alarm rate	0.1	0.1	0.2	-0.4	0.2	0.1	-0.2	0.3	0.3	-0.4
Reaction time premature initiation rate	0.6	0.9	5.5	-0.2	0.3	0.4	-0.4	0.6	0.6	2.3
Reaction time premature initiations	0.4	1.4	5.9	-1.1	1.2	-0.5	0.6	-0.5	-0.5	2.4
Std. dev. reaction times	0.5	1.5	2.1	-1.1	1.2	-1.4	1.5	-1.4	-1.4	-0.2
Reaction time trials completed	0.2	0.7	1.0	-0.7	0.9	-0.8	0.9	-1.0	-1.0	0.4
Reaction time trials AUC	0.1	0.5	0.8	-0.5	0.7	-0.6	0.8	-0.9	-0.9	0.3
Run reversals in cocaine runway, females	0.7	0.8	1.2	0.7	-0.8	1.1	-1.0	0.9	0.9	0.6
Run reversals in cocaine runway, males	0.5	0.6	1.4	-0.1	0.0	0.6	-0.8	0.8	0.8	-1.2
Latency to leave start box in cocaine runway	2.5	3.4	4.6	1.8	-1.4	2.1	-2.1	2.1	2.1	-0.6
Latency to leave start box in cocaine runway, F	0.6	0.8	1.2	0.8	-0.8	1.0	-1.1	1.0	1.0	0.2
Latency to leave start box in cocaine runway, M	2.5	2.4	3.1	1.6	-0.9	1.8	-1.6	1.6	1.6	-1.5
Std. dev. time between licks in bursts	0.1	0.1	0.2	0.5	-0.4	0.3	-0.3	0.2	0.2	-0.5
Total sessions with >9 infusions	0.4	0.5	1.0	1.0	-1.0	0.6	-0.5	0.5	0.5	-0.3
Short access day 1 total inactive lever presses	0.2	0.5	0.6	0.8	-0.8	0.7	-0.8	0.8	0.8	0.1
Short access day 10 total inactive lever presses	0.1	0.5	0.9	-0.1	0.1	-0.7	0.9	-0.9	-0.9	-0.6
Short access day 1 total infusions	0.5	1.0	1.7	1.3	-1.0	1.0	-0.9	0.9	0.9	-0.8
Short access day 10 total infusions	2.3	3.7	6.4	2.5	-2.2	2.0	-1.9	1.9	1.9	0.2
Short access total infusions	1.6	2.3	4.0	2.0	-1.6	1.6	-1.5	1.5	1.5	-0.1
Short access day 1 locomotion	0.1	0.2	0.3	0.4	-0.4	0.5	-0.5	0.5	0.5	-0.2
Short access day 10 total locomotion	0.5	1.9	4.2	2.1	-2.0	1.2	-1.0	1.0	1.0	0.8
Short access total locomotion	1.0	1.5	2.9	1.7	-1.7	1.2	-1.1	1.1	1.1	0.5
One hour access (0.3 mA shock)	3.5	4.2	5.3	2.3	-2.1	2.1	-2.2	2.2	2.2	-0.6
Compulsive drug intake	2.4	3.6	4.5	-1.9	1.8	-2.0	2.1	-2.1	-2.1	0.7
One hour access (shock baseline)	3.2	8.3	10.0	3.0	-2.7	3.0	-3.2	3.2	3.2	-1.6
Social response proportion	0.2	0.2	0.4	0.1	0.1	0.7	-0.4	0.5	0.5	-0.4
Social responses	0.5	0.7	2.1	-1.0	1.4	-0.5	0.7	-0.6	-0.6	-0.5
Social time	1.5	2.3	3.5	-1.4	1.9	-1.5	1.7	-1.7	-1.7	-0.3
Soleus weight	1.0	2.9	9.6	1.7	-1.6	1.4	-1.2	1.0	1.0	-3.1
Bone: stiffness	0.2	0.4	0.8	0.3	-0.1	0.6	-0.9	0.8	0.8	0.6
Tibialis anterior weight	4.2	14.4	31.5	-3.9	3.5	-3.7	3.0	-3.1	-3.1	5.6
Time to tail flick, vehicle, before self-admin	0.7	0.8	1.0	1.0	-0.9	0.9	-1.0	1.0	1.0	0.5
Time to tail flick, vehicle, after self-admin	0.1	0.2	1.1	0.5	-0.2	0.2	-0.2	0.2	0.2	1.1
Time to tail flick, test, before self-admin	0.9	1.0	1.4	0.9	-1.0	1.2	-1.1	1.1	1.1	0.5
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.3	0.3	-0.2	0.2	-0.2	-0.2	-0.1
Delta time to tail flick, vehicle, before/after SA	0.5	0.6	0.7	-0.5	0.7	-0.8	0.8	-0.8	-0.8	0.7
Delta time to tail flick, test, before/after SA	1.8	2.3	3.0	-1.6	1.7	-1.7	1.6	-1.6	-1.6	-0.1
Tibia length	0.2	0.6	3.2	-0.7	0.4	-0.1	-0.1	-0.1	-0.1	1.8
Ambulatory time before self-admin	0.1	0.2	1.5	-0.0	0.2	-0.1	-0.1	0.1	0.1	1.2
Ambulatory time after self-admin	0.0	0.0	0.1	0.1	-0.1	0.1	-0.2	0.2	0.2	0.4
Bone: tissue strength	0.2	0.2	1.0	0.5	-0.3	0.4	-0.3	0.2	0.2	-1.0
Total heroin consumption	6.7	7.9	10.7	-3.3	3.1	-2.9	2.6	-2.6	-2.6	2.4
Bone: trabecular number	0.2	0.4	1.5	0.3	-0.5	0.5	-0.5	0.6	0.6	1.2
Bone: trabecular spacing	0.9	1.3	2.4	-0.5	0.6	-1.1	1.2	-1.6	-1.6	-0.9
Bone: trabecular thickness	0.5	0.7	1.0	0.7	-0.7	0.9	-1.0	1.0	1.0	-0.5
Bone: trabecular tissue density	0.9	1.5	7.1	0.7	-0.8	0.7	-0.8	0.7	0.7	-2.7
Water consumed over 24 hours	0.3	0.5	1.0	-1.0	0.9	-0.6	0.8	-0.5	-0.5	0.6
Number of responses in last shaping day	0.9	1.2	1.5	-1.2	1.2	-1.0	1.1	-1.1	-1.1	0.8