Hub : Genes

Fosl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Fosl1 0.03 0.02 4.1e-03 0.01 0.01 0 0 4.5e-02 2.2e-02 7.9e-02 8.6e-02
2 BLA gene expression Fosl1 0.12 0.07 3.7e-05 0.06 0.08 0.06 0.07 5.2e-04 3.2e-05 2.5e-04 1.4e-04
3 Adipose gene expression Fosl1 0.08 0.04 2.8e-06 0.03 0.04 0.05 0.04 2.5e-04 4.3e-05 5.7e-06 4.6e-05
4 Brain gene expression Fosl1 0.09 0.05 9.5e-06 0.05 0.04 0.05 0.05 3.1e-05 1.6e-04 8.8e-06 8.8e-06
5 NAcc gene expression Fosl1 0.11 0.06 1.1e-11 0.11 0.11 0.12 0.12 6.1e-13 2.0e-12 2.7e-13 2.0e-13
6 PL gene expression Fosl1 0.2 0.08 0.0e+00 0.17 0.17 0.16 0.17 5.2e-18 6.2e-18 1.4e-17 3.6e-18
7 pVTA gene expression Fosl1 0.41 0.16 7.0e-10 0.21 0.2 0.21 0.21 1.7e-09 5.1e-09 1.4e-09 1.7e-09
8 OFC gene expression Fosl1 0.3 0.16 1.6e-03 0.09 0.05 0.06 0.11 3.3e-03 2.8e-02 1.6e-02 1.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density3.05.07.60.8-2.32.0-2.8-2.6-2.32.2-2.3
Area under the delay curve0.80.81.9-0.4-0.9-0.2-0.9-0.9-1.20.9-1.4
BMI with tail6.521.028.63.1-5.25.3-4.3-3.9-4.95.2-4.2
BMI without tail3.26.510.71.5-2.73.3-2.3-1.9-2.73.2-2.4
Body weight2.08.318.64.3-3.13.2-2.6-1.9-2.82.7-1.5
Weight adjusted by age0.50.63.51.9-0.40.9-0.4-0.2-0.3-0.10.4
Bone surface4.07.010.93.0-2.72.7-3.3-3.0-2.41.9-1.6
Bone volume2.94.97.61.8-2.42.3-2.7-2.8-2.11.6-1.7
Breakpoint value in progressive ratio session1.01.15.32.3-1.00.8-0.9-0.7-0.70.50.1
Number of licking bursts0.20.20.60.8-0.50.5-0.6-0.4-0.20.2-0.0
Context. condit. distance diff. score0.40.53.0-1.70.4-0.40.70.30.20.0-0.3
Locomotion velocity, session 10.30.30.8-0.10.6-0.40.70.90.4-0.30.4
Locomotion distance, session 11.92.43.70.7-1.61.5-1.9-1.3-1.81.9-1.6
Locomotion velocity, session 21.72.03.92.0-1.61.6-1.1-0.9-1.51.4-0.9
Locomotion distance, session 21.31.82.70.9-1.51.2-1.5-0.9-1.61.6-1.4
Locomotion velocity, session 30.60.71.4-0.3-0.90.9-0.6-0.6-1.01.2-1.2
Locomotion distance, session 30.00.00.0-0.2-0.0-0.20.1-0.1-0.00.1-0.1
Stereotopy head waving bouts, day 30.60.71.6-1.0-0.50.7-0.6-0.3-0.81.1-1.3
Stereotopy head waving duration, day 30.30.41.3-1.2-0.20.5-0.4-0.3-0.40.6-0.9
Locomotion velocity, session 71.51.62.8-0.4-1.51.3-0.9-1.0-1.41.6-1.7
Locomotion distance, session 70.50.61.5-0.2-0.80.6-0.3-0.3-1.01.2-0.9
Stereotopy head waving bouts, day 70.40.51.3-0.2-0.60.7-0.9-1.1-0.50.4-0.7
Stereotopy head waving duration, day 72.02.43.91.2-1.61.7-1.8-2.0-1.41.2-1.2
Locomotion velocity, session 80.10.10.70.90.2-0.20.10.40.00.10.3
Locomotion distance, session 80.30.40.7-0.4-0.70.7-0.4-0.4-0.70.8-0.9
Degree of sensitization distance0.70.71.2-0.1-0.90.7-0.7-0.5-1.11.1-1.0
Degree of sensitization stereotypy0.80.91.91.0-1.01.1-1.1-1.4-0.70.5-0.5
Conditioned locomotion0.30.32.11.4-0.20.4-0.10.50.00.10.4
Cocaine response after cond. corrected0.50.52.6-1.60.7-0.70.50.60.3-0.1-0.3
Cocaine response after cond. not corrected0.30.42.0-1.40.5-0.50.20.30.10.0-0.3
Cocaine response before conditioning0.30.41.21.1-0.60.6-0.4-0.8-0.40.10.1
Saline control response1.21.65.22.3-1.11.2-1.2-0.8-1.21.2-0.6
Bone: connectivity density4.26.611.01.9-2.62.4-3.3-2.8-2.62.4-2.2
Bone: cortical apparent density0.00.10.30.6-0.10.1-0.10.2-0.00.10.1
Bone: cortical area0.20.31.71.3-0.20.50.20.20.2-0.40.6
Bone: cortical porosity0.91.01.40.3-1.01.2-1.0-0.9-1.01.1-1.2
Bone: cortical porosity1.01.01.50.7-1.01.2-1.1-0.8-1.01.2-1.0
Bone: cortical thickness0.81.35.32.30.3-0.20.71.20.6-0.51.6
Bone: cortical thickness0.70.81.80.70.7-0.91.01.30.7-0.51.1
Bone: cortical tissue density0.00.10.40.6-0.00.1-0.10.20.00.00.1
Condit. Reinf. active minus inactive responses0.40.40.60.5-0.70.6-0.7-0.7-0.70.8-0.6
Condit. Reinf. active-inactive response ratio0.10.10.30.2-0.20.3-0.5-0.5-0.30.3-0.2
Condit. Reinf. active responses0.30.40.60.4-0.80.8-0.5-0.5-0.60.7-0.5
Condit. Reinf. inactive responses0.20.20.50.1-0.70.7-0.2-0.2-0.50.5-0.4
Incentive salience index mean0.91.11.50.7-1.21.2-0.9-0.9-1.11.2-0.9
Condit. Reinf. lever presses0.30.41.00.9-0.81.0-0.3-0.4-0.50.5-0.1
Condit. Reinf. active minus inactive responses0.30.31.1-0.1-0.4-0.0-1.0-1.1-0.30.1-0.4
Condit. Reinf. active-inactive response ratio0.10.10.4-0.4-0.30.0-0.5-0.60.1-0.3-0.3
Condit. Reinf. active responses1.01.43.40.3-1.10.6-1.8-1.7-1.10.9-1.1
Condit. Reinf. inactive responses1.41.72.90.4-1.10.8-1.7-1.6-1.61.5-1.3
Condit. Reinf. lever presses1.21.64.52.1-1.30.9-1.5-1.6-1.00.5-0.3
Condit. Reinf. lever reinforcers received0.91.33.30.6-1.10.6-1.8-1.7-1.10.7-0.9
Conditioned reinforcement - actives0.50.51.7-0.30.6-0.50.50.40.9-1.30.7
Conditioned reinforcement - inactives2.73.06.7-2.61.5-2.21.30.81.7-2.20.8
Conditioned locomotion5.06.011.0-3.32.4-2.52.42.02.5-2.61.4
Patch foraging indifference point 0 sec0.10.10.4-0.2-0.2-0.0-0.5-0.6-0.30.2-0.3
Patch foraging indifference point AUC0.91.05.52.3-0.80.7-0.9-0.3-0.40.10.2
Delay disc. indifference point, 0s delay0.70.82.5-1.0-0.7-0.1-0.5-0.3-1.10.9-1.6
Delay disc. indifference point, 16s delay0.50.51.5-0.8-0.6-0.3-0.6-1.2-0.50.3-0.9
Delay disc. indifference point, 2s delay0.00.10.1-0.3-0.2-0.0-0.2-0.0-0.30.2-0.3
Delay disc. indifference point, 24s delay0.20.20.8-0.50.4-0.90.40.20.1-0.1-0.1
Delay disc. indifference point, 4s delay0.50.51.1-0.7-0.4-0.3-0.5-0.4-1.00.9-1.0
Delay disc. indifference point, 8s delay0.40.41.1-0.4-0.4-0.7-0.5-0.3-0.90.7-1.0
Indifference point function ln k2.83.915.4-3.91.8-1.82.21.61.3-0.70.2
Indifference point function log k2.83.915.4-3.91.8-1.82.21.61.3-0.70.2
Patch foraging total patch changes 0 sec0.00.00.1-0.20.3-0.4-0.00.00.1-0.10.2
Patch foraging total patch changes 12 sec2.12.77.72.8-1.71.5-1.9-1.2-1.41.2-0.6
Patch foraging total patch changes 18 sec0.70.92.21.0-1.00.7-1.5-1.0-0.90.6-0.7
Patch foraging total patch changes 24 sec0.40.53.31.8-0.20.2-0.9-0.1-0.2-0.00.4
Patch foraging total patch changes 6 sec0.81.22.31.3-1.10.7-1.5-1.1-1.11.1-0.8
Patch foraging time to switch 0 sec3.65.57.72.0-2.82.4-2.3-2.6-2.42.1-2.0
Patch foraging water rate 0 sec4.87.710.1-2.83.2-3.02.62.73.0-2.72.3
Patch foraging water rate 12 sec7.211.118.5-4.33.9-3.43.33.33.3-2.62.0
Patch foraging water rate 18 sec2.12.86.4-2.51.9-2.01.51.51.4-1.00.9
Patch foraging water rate 24 sec4.05.58.0-2.82.7-2.32.62.42.3-1.91.6
Patch foraging water rate 6 sec3.95.78.2-2.82.9-2.82.12.52.3-1.81.6
Seeking ratio, delayed vs. immediate footshock0.60.61.2-0.1-0.90.4-0.7-0.8-1.10.9-1.1
Distance traveled before self-admin0.30.30.91.0-0.50.8-0.4-0.5-0.30.00.0
Distance traveled after self-admin0.10.10.40.6-0.20.5-0.2-0.2-0.0-0.10.2
Extensor digitorum longus weight2.59.736.26.0-3.13.6-2.1-1.4-2.62.3-0.4
Bone: elastic displacement2.73.14.4-1.32.0-2.11.62.11.8-1.41.5
Bone: elastic work0.50.61.70.70.7-0.60.61.30.6-0.31.0
Bone: endosteal estimation0.71.53.2-1.2-1.11.3-0.9-1.3-1.11.0-1.8
Bone: endosteal perimeter0.91.83.4-1.2-1.11.3-1.4-1.9-1.00.7-1.7
Epididymis fat weight0.41.06.7-2.60.4-0.70.2-0.00.5-0.5-0.4
Delta time in closed arm before/after self-admin0.20.20.5-0.20.3-0.60.20.7-0.10.6-0.2
Delta time in open arm before/after self-admin0.20.20.70.40.1-0.20.2-0.20.4-0.90.6
Diff in mean of infusions in LGA sessions0.30.30.70.80.3-0.90.00.20.4-0.50.7
Delay discount exponential model param0.60.61.30.30.80.30.80.71.1-0.81.2
Extinction: sum of active levers before priming3.43.46.72.6-2.02.1-1.8-1.6-1.71.7-0.9
Active lever presses in extinction session 60.90.93.31.80.30.00.40.60.7-0.91.4
Bone: final force1.01.75.82.4-1.31.6-0.9-0.8-1.00.9-0.3
Bone: final moment0.91.55.12.3-1.21.5-0.9-0.8-1.00.8-0.3
Food consumed during 24 hour testing period0.60.81.40.30.7-1.00.80.21.0-1.21.1
Glucose0.91.33.1-1.8-0.70.6-0.8-1.2-0.91.0-1.7
Heart weight0.71.06.2-2.50.6-1.10.1-0.20.1-0.1-0.7
Delay discount hyperbolic model param0.50.51.10.30.70.20.70.61.0-0.81.0
Intermittent access intake day 1-15 change1.51.53.3-0.61.3-1.21.10.81.5-1.81.2
Intermittent access intake escalation0.80.82.0-0.60.9-1.00.70.61.0-1.40.7
Intermittent access intake escalation 21.31.32.8-0.21.1-1.01.11.01.3-1.71.2
Intermitt. access day 1 inactive lever presses0.50.62.4-1.50.5-0.70.5-0.30.6-0.80.1
Intermitt. access day 15 inactive lever presses0.80.92.0-1.40.7-1.30.4-0.00.8-1.40.3
Intermitt. access escalation Index0.90.84.1-2.0-0.2-0.4-0.10.0-0.40.7-1.2
Intermittent access day 1 total infusions1.82.16.6-2.6-1.00.1-1.2-1.4-0.90.8-2.1
Intermittent access day 15 total infusions1.51.79.0-3.00.7-1.40.2-0.20.8-1.2-0.4
Intermittent access terminal intake (last 3 days)0.91.05.7-2.40.2-0.9-0.2-0.60.4-0.9-0.6
Intermittent access total infusions1.11.24.8-2.2-0.6-0.3-1.0-1.2-0.40.0-1.4
Intermittent access day 1 locomotion2.12.24.5-2.1-1.10.5-1.4-1.4-1.21.4-2.1
Intermittent access day 15 total locomotion0.80.95.1-2.30.3-0.9-0.1-0.40.4-0.8-0.5
Intermittent access total locomotion1.51.76.6-2.6-0.80.0-1.0-1.4-0.60.2-1.8
Intermittent access standard deviation1.01.12.2-1.11.0-1.20.80.71.1-1.50.6
Left kidney weight0.30.81.2-1.10.7-0.51.00.91.0-1.00.5
Right kidney weight0.51.43.1-0.10.9-1.01.10.81.5-1.81.5
Cocaine induced anxiety0.20.20.60.10.3-0.10.40.30.5-0.70.6
Post-drug Anxiety0.60.72.01.40.30.70.50.40.6-1.01.2
Baseline Anxiety0.40.53.11.8-0.10.5-0.10.2-0.10.20.6
Tail length0.82.44.41.11.5-1.11.42.01.5-1.32.1
Length with tail0.51.78.62.90.3-0.40.30.90.5-0.81.6
Length without tail0.51.06.82.6-0.60.1-0.6-0.3-0.50.10.5
Times rat made contact with spout0.60.71.10.6-0.70.7-1.1-0.9-0.90.9-0.8
Lifetime Intake1.21.34.4-2.1-0.7-0.1-1.1-1.2-0.60.4-1.6
Liver weight, left0.10.20.7-0.30.20.60.80.50.20.00.0
Liver weight, right0.10.20.6-0.50.4-0.20.70.60.20.1-0.0
Locomotor activity2.03.25.2-2.02.1-2.31.61.81.6-1.41.3
Locomotor testing distance2.44.16.6-2.62.5-2.41.82.11.7-1.41.2
Locomotor testing rearing1.11.76.1-2.51.6-1.70.60.80.7-0.60.2
Locomotion in novel chamber1.82.25.6-2.41.2-1.71.20.61.4-1.90.5
Locomotion in novel chamber post-restriction1.11.33.8-2.00.9-1.61.00.60.8-1.00.2
Fecal boli incidents, locomotor time 10.20.30.70.5-0.20.1-0.2-0.80.3-0.80.6
Change in fecal boli incidents, locomotor task0.50.51.5-0.3-0.40.3-0.4-0.3-0.91.2-0.9
Time >=10cm from walls, locomotor time 11.31.33.4-0.5-1.30.3-1.4-1.8-0.80.6-1.5
Bouts of movement, locomotor time 10.30.42.11.4-0.3-0.2-0.5-0.6-0.3-0.10.3
Total resting periods, locomotor time 10.40.41.61.3-0.5-0.0-0.6-0.9-0.4-0.10.1
Rest time, locomotor task time 11.41.62.4-1.31.3-1.61.30.91.2-1.40.9
Distance moved, locomotor task time 11.11.21.60.3-1.21.2-1.1-0.8-1.11.2-1.2
Vertical activity count, locomotor time 10.30.31.5-1.20.5-0.60.50.40.4-0.30.1
Time >=10cm from walls, locomotor time 20.10.10.30.3-0.40.6-0.3-0.50.0-0.0-0.2
Bouts of movement, locomotor time 20.30.30.80.9-0.60.2-0.6-0.7-0.50.3-0.2
Total resting periods, locomotor time 20.30.30.50.6-0.60.2-0.6-0.7-0.60.4-0.4
Rest time, locomotor task time 20.80.93.2-1.80.6-1.30.80.60.4-0.8-0.1
Distance moved, locomotor task time 20.30.41.61.2-0.31.0-0.20.1-0.10.30.3
Vertical activity count, locomotor time 21.31.42.3-0.21.5-0.81.41.51.3-0.91.4
Light reinforcement 10.20.30.5-0.70.7-0.60.40.50.6-0.50.2
Light reinforcement 20.71.02.3-0.80.8-0.90.90.31.3-1.50.9
Bone: marrow area0.81.73.5-1.3-1.11.3-1.0-1.3-1.11.1-1.9
Bone: maximum diameter0.10.20.60.8-0.00.30.1-0.20.4-0.70.5
Bone: maximum force3.15.37.82.8-2.62.6-2.5-2.2-2.11.9-1.4
Bone: maximum moment2.74.66.62.6-2.42.5-2.3-2.1-2.01.8-1.4
Mean time between licks in bursts0.10.10.40.40.3-0.0-0.00.6-0.20.50.0
Mean num. licks in bursts0.10.10.5-0.70.1-0.1-0.1-0.2-0.20.3-0.6
Cd content in liver1.61.73.0-1.11.3-1.51.20.91.5-1.71.0
Co content in liver2.73.15.3-1.72.0-1.92.12.31.6-1.21.0
Cu content in liver0.40.50.90.7-0.90.9-0.4-0.4-0.80.7-0.6
Fe content in liver0.10.10.20.40.2-0.10.10.20.3-0.40.4
K content in liver3.02.93.81.4-1.91.9-1.6-1.6-1.91.8-1.4
Mg content in liver4.24.35.50.4-2.22.2-2.1-2.2-2.32.3-2.2
Mn content in liver1.11.24.22.0-1.01.0-1.4-1.2-0.60.30.1
Na content in liver0.40.41.71.30.10.20.40.50.4-0.51.0
Rb content in liver0.81.02.2-1.5-0.60.5-0.6-0.8-0.91.0-1.4
Se content in liver0.40.51.90.3-0.70.3-1.4-1.2-0.4-0.1-0.5
Sr content in liver0.90.83.21.80.40.00.60.60.6-0.81.2
Zn content in liver0.80.81.81.3-1.11.1-0.7-0.7-0.80.9-0.4
Bone: minimum diameter1.63.05.0-0.9-1.71.9-1.5-1.9-1.71.7-2.2
Time in familiar zone, hab. session 10.30.20.5-0.4-0.40.6-0.2-0.7-0.50.5-0.5
Time in novel zone, hab. session 11.01.02.3-0.71.1-1.50.91.20.8-0.80.6
Total zone transitions, hab. session 10.50.71.41.2-1.00.8-1.0-0.5-0.80.7-0.4
Total locomotion distance, hab. session 10.10.20.4-0.5-0.50.3-0.1-0.2-0.40.4-0.7
Locomotion velocity, hab. session 10.20.30.4-0.0-0.70.6-0.4-0.3-0.50.6-0.7
Time in familiar zone, hab. session 20.50.51.0-0.40.9-0.70.81.00.5-0.20.6
Time in novel zone, hab. session 20.90.91.20.4-1.01.0-1.1-1.1-0.90.7-1.1
Total zone transitions, hab. session 25.47.011.71.3-2.62.5-3.4-2.6-2.82.8-2.7
Total locomotion distance, hab. session 22.22.94.2-0.1-1.71.5-2.0-1.6-1.92.0-2.1
Locomotion velocity, hab. session 21.92.63.9-0.2-1.61.4-1.9-1.6-1.71.8-2.0
Novel to familiar place preference ratio1.01.02.01.4-1.11.1-1.0-1.3-0.70.3-0.4
Novelty place preference0.70.71.51.0-1.00.9-0.8-1.2-0.60.3-0.5
Time in novel zone, NPP test0.50.51.20.8-0.80.8-0.7-1.1-0.60.3-0.5
Total zone transitions, NPP test1.92.73.71.9-1.81.8-1.9-1.3-1.71.6-1.0
Total locomotion distance, NPP test0.60.91.30.3-1.10.9-1.0-0.7-1.11.2-1.1
Locomotion velocity, NPP test0.60.81.20.4-1.10.9-0.9-0.6-1.01.0-0.9
Intraocular pressure1.72.45.5-0.91.6-1.61.00.91.9-2.31.6
Delta distance traveled before/after self-admin0.10.10.3-0.20.4-0.50.20.40.3-0.00.2
Delta ambulatory time before/after self-admin0.10.10.3-0.20.4-0.50.30.50.20.10.1
Parametrial fat weight0.71.34.2-2.1-0.70.9-0.7-0.8-0.70.8-1.6
Pavlov. Cond. lever latency0.30.41.0-0.60.8-1.00.50.50.7-0.60.2
Pavlov. Cond. magazine entry latency1.51.92.80.5-1.51.5-1.7-1.6-1.41.4-1.2
Pavlov. Cond. change in total contacts0.60.61.30.5-1.01.1-0.8-1.1-0.60.4-0.2
Pavlov. Cond. index score0.10.20.40.5-0.50.6-0.4-0.5-0.30.20.1
Pavlov. Cond. latency score0.20.30.60.3-0.60.8-0.5-0.5-0.50.5-0.1
Pavlov. Cond. lever contacts0.10.10.20.1-0.40.5-0.2-0.2-0.40.4-0.0
Pavlov. Cond. magazine entry number0.10.10.6-0.70.2-0.20.30.4-0.10.2-0.4
Pavlov. Cond. intertrial magazine entries0.60.71.2-0.50.8-1.10.70.60.9-1.10.8
Pavlov. Cond. lever-magazine prob. diff.0.30.40.80.8-0.70.9-0.6-0.6-0.50.4-0.0
Pavlov. Cond. response bias0.10.10.20.5-0.30.2-0.2-0.3-0.0-0.10.4
Pavlov. Cond. lever latency0.20.31.2-1.10.7-0.40.40.80.4-0.10.0
Pavlov. Cond. magazine entry latency2.52.95.62.4-1.91.6-1.8-1.7-1.71.4-1.0
Pavlov. Cond. change in total contacts1.72.34.82.2-1.81.4-1.6-2.0-1.20.6-0.8
Pavlov. Cond. index score1.52.05.02.2-1.61.3-1.2-1.6-1.20.8-0.6
Pavlov. Cond. latency score1.31.74.22.0-1.51.3-1.1-1.4-1.10.7-0.6
Pavlov. Cond. lever contacts0.20.21.11.0-0.1-0.30.1-0.30.2-0.50.5
Pavlov. Cond. magazine entry number3.64.410.7-3.32.2-2.02.12.11.9-1.41.1
Pavlov. Cond. intertrial magazine entries0.50.61.9-1.40.8-0.80.70.50.7-0.70.4
Pavlov. Cond. lever-magazine prob. diff.1.82.35.82.4-1.71.4-1.3-1.7-1.30.9-0.7
Pavlov. Cond. response bias0.70.93.61.9-1.00.6-0.9-1.1-0.70.2-0.1
Time in closed arm before self-admin0.20.20.50.3-0.40.7-0.5-0.7-0.2-0.0-0.2
Time in closed arm after self-admin0.10.10.3-0.1-0.2-0.0-0.3-0.1-0.30.5-0.4
Time in open arm before self-admin0.40.41.3-1.10.4-0.30.50.8-0.10.7-0.5
Time in open arm after self-admin0.60.60.9-0.60.9-0.70.90.90.8-0.70.7
Bone: periosteal estimation0.20.31.10.2-0.71.0-0.3-0.6-0.40.2-0.5
Bone: periosteal perimeter0.40.61.00.5-0.81.0-1.0-1.0-0.60.3-0.7
Bone: post-yield work10.113.719.21.2-4.14.2-4.1-4.4-3.63.3-3.6
Progressive ratio test 1 active lever presses0.60.73.5-1.90.5-0.90.10.10.5-0.7-0.2
Progressive ratio test 1 breakpoint0.70.73.1-1.80.7-1.00.30.30.6-0.80.0
Progressive ratio test 1 inactive lever presses0.30.31.7-1.30.1-0.6-0.1-0.10.0-0.1-0.4
Progressive ratio test 2 active lever presses0.80.94.4-2.10.5-0.90.0-0.20.6-1.1-0.2
Progressive ratio test 2 breakpoint1.61.86.2-2.51.1-1.60.70.41.2-1.50.3
Progressive ratio test 2 inactive lever presses1.61.910.4-3.20.6-1.20.2-0.20.8-1.3-0.6
Incentive Sensitization - Responses0.10.10.4-0.5-0.2-0.0-0.5-0.60.0-0.2-0.3
Incentive Sensitization - Breakpoint0.10.10.4-0.6-0.0-0.2-0.3-0.50.2-0.4-0.2
Sum of active levers in priming session hrs 5-62.22.24.71.70.9-0.71.00.91.6-2.12.2
Progressive ratio5.05.87.31.7-2.72.5-2.6-2.4-2.72.3-2.2
Food seeking constrained by brief footshock0.00.00.10.30.10.20.10.3-0.20.30.1
Seeking ratio, punishment vs. effort3.34.05.5-1.82.4-2.12.22.22.0-1.61.6
Retroperitoneal fat weight0.93.019.0-4.41.0-1.20.70.20.9-0.7-0.7
Reaction time number correct0.40.51.10.60.7-0.80.20.70.7-0.81.0
Reaction time mean minus median1.31.76.32.5-1.41.1-1.1-1.4-1.00.3-0.2
Reaction time mean minus median AUC0.40.53.31.8-0.50.3-0.2-0.4-0.1-0.40.5
Reaction time num false alarms0.50.71.9-0.70.9-0.81.11.40.5-0.10.4
Reaction time num false alarms AUC0.20.31.10.00.5-0.50.81.10.20.10.4
Reaction time trials correct on left0.40.51.10.60.7-0.80.20.70.7-0.81.0
Reaction time trials on left0.40.61.30.70.7-0.80.30.80.8-0.81.1
Reaction time mean0.10.10.20.4-0.30.10.3-0.4-0.1-0.40.2
Reaction time mean AUC0.10.10.40.4-0.50.20.1-0.6-0.2-0.30.0
Median of all reaction times0.00.10.2-0.1-0.20.10.4-0.3-0.1-0.30.0
Reaction time omissions0.40.52.61.6-0.70.5-0.4-0.4-0.50.10.3
Reaction time false alarm rate0.20.30.8-0.60.3-0.30.90.80.00.2-0.0
Reaction time premature initiation rate0.30.42.21.50.00.2-0.10.5-0.40.60.3
Reaction time premature initiations0.50.84.42.10.4-0.30.00.90.1-0.00.9
Std. dev. reaction times0.30.42.01.4-0.70.4-0.2-0.8-0.4-0.20.1
Reaction time trials completed0.40.61.30.70.7-0.80.30.80.8-0.81.1
Reaction time trials AUC0.30.50.90.50.7-0.80.20.80.7-0.70.9
Run reversals in cocaine runway, females2.82.75.90.5-1.81.5-1.4-1.1-1.82.4-1.8
Run reversals in cocaine runway, males3.23.14.3-0.51.9-1.52.02.11.9-1.81.9
Latency to leave start box in cocaine runway1.01.12.00.1-1.20.9-1.1-1.4-1.11.1-1.1
Latency to leave start box in cocaine runway, F0.70.71.00.2-1.01.0-0.9-1.0-0.90.8-0.9
Latency to leave start box in cocaine runway, M0.00.00.10.1-0.30.0-0.2-0.3-0.10.2-0.1
Std. dev. time between licks in bursts0.70.82.7-0.61.0-0.61.21.70.6-0.20.4
Total sessions with >9 infusions0.60.72.1-1.5-0.50.0-0.6-0.7-0.60.7-1.2
Short access day 1 total inactive lever presses0.70.84.8-2.20.3-0.90.30.20.2-0.2-0.5
Short access day 10 total inactive lever presses1.11.24.9-2.21.0-1.21.10.60.8-0.40.1
Short access day 1 total infusions1.41.53.3-1.8-1.00.2-1.1-1.2-1.01.0-1.8
Short access day 10 total infusions3.43.87.0-1.1-2.00.9-2.4-2.2-2.01.8-2.6
Short access total infusions1.41.63.3-1.2-1.20.4-1.4-1.2-1.21.2-1.8
Short access day 1 locomotion1.31.42.8-1.7-0.90.3-1.2-1.4-0.91.0-1.6
Short access day 10 total locomotion1.41.53.1-1.3-1.10.6-1.3-1.3-1.11.2-1.8
Short access total locomotion1.51.52.9-1.2-1.10.7-1.3-1.3-1.21.3-1.7
One hour access (0.3 mA shock)2.83.213.2-3.61.4-2.10.90.41.4-1.7-0.0
Compulsive drug intake0.40.41.91.40.10.10.10.8-0.20.70.5
One hour access (shock baseline)2.22.69.9-3.11.1-1.70.7-0.21.4-2.00.1
Social response proportion0.60.71.41.1-0.70.4-1.1-1.2-0.70.3-0.5
Social responses0.00.00.20.40.3-0.2-0.0-0.00.1-0.20.2
Social time0.10.10.20.50.40.00.10.20.1-0.10.4
Soleus weight1.44.113.5-3.71.8-1.62.31.71.7-1.40.5
Bone: stiffness3.14.96.72.4-2.52.6-2.4-2.4-2.11.8-1.4
Tibialis anterior weight2.06.844.66.7-1.61.8-0.50.1-0.70.31.7
Time to tail flick, vehicle, before self-admin0.70.71.10.8-1.00.6-1.1-1.0-0.90.6-0.7
Time to tail flick, vehicle, after self-admin1.82.03.31.0-1.41.5-1.3-1.1-1.61.8-1.4
Time to tail flick, test, before self-admin1.41.33.4-0.9-1.00.4-1.0-0.9-1.31.4-1.8
Time to tail flick, test, after self-admin0.10.10.10.00.3-0.40.1-0.10.3-0.40.2
Delta time to tail flick, vehicle, before/after SA0.70.71.40.5-0.70.9-0.7-0.7-0.91.2-0.9
Delta time to tail flick, test, before/after SA2.32.14.71.11.4-0.71.31.01.6-1.72.2
Tibia length0.41.25.32.3-0.10.40.30.30.9-1.31.4
Ambulatory time before self-admin0.30.30.90.9-0.50.5-0.5-0.7-0.1-0.30.2
Ambulatory time after self-admin0.30.30.80.1-0.60.5-0.7-0.9-0.40.1-0.4
Bone: tissue strength0.20.20.60.3-0.40.4-0.8-0.7-0.30.2-0.3
Total heroin consumption2.02.48.42.9-1.31.9-1.3-0.9-1.11.2-0.1
Bone: trabecular number2.43.77.11.0-2.01.5-2.7-2.6-1.91.5-1.7
Bone: trabecular spacing0.40.50.9-0.70.7-0.61.00.90.5-0.20.2
Bone: trabecular thickness0.91.02.1-0.6-0.90.5-1.2-1.4-1.00.9-1.1
Bone: trabecular tissue density1.92.65.1-2.31.6-1.51.71.41.8-1.60.8
Water consumed over 24 hours0.20.20.70.8-0.20.0-0.6-0.5-0.30.20.1
Number of responses in last shaping day0.80.82.0-1.41.0-1.00.90.80.8-0.70.5