Hub : Genes

Fosl1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Fosl1 0.03 0.02 6.8e-03 0 0 0 0 1.7e-01 7.2e-02 3.4e-01 3.1e-01
2 BLA gene expression Fosl1 0.12 0.07 2.8e-05 0.05 0.07 0.07 0.07 7.5e-04 8.5e-05 2.0e-04 1.6e-04
3 IC gene expression Fosl1 0.24 0.13 4.3e-07 0.14 0.12 0.16 0.16 1.9e-06 1.2e-05 3.5e-07 2.4e-07
4 pVTA gene expression Fosl1 0.35 0.15 2.5e-09 0.1 0.12 0.13 0.12 1.1e-08 3.9e-10 1.1e-10 1.5e-09
5 NAcc gene expression Fosl1 0.13 0.07 1.1e-16 0.09 0.11 0.1 0.11 5.1e-14 1.2e-16 3.8e-15 9.9e-16
6 Adipose gene expression Fosl1 0.07 0.04 1.6e-06 0.04 0.04 0.04 0.04 4.2e-05 1.8e-05 7.6e-05 1.2e-05
7 Brain gene expression Fosl1 0.09 0.05 1.2e-05 0.06 0.04 0.05 0.05 3.5e-06 9.5e-05 2.5e-05 1.3e-05
8 PL gene expression Fosl1 0.21 0.09 0.0e+00 0.17 0.16 0.17 0.17 6.6e-18 1.4e-17 4.9e-18 4.7e-18
9 OFC gene expression Fosl1 0.27 0.15 3.5e-03 0.14 0.04 0.08 0.1 4.5e-04 3.2e-02 6.1e-03 2.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density2.64.57.40.8-2.3-2.5-1.6-2.3-2.0-2.7-2.4-1.8
Area under the delay curve0.91.01.4-0.3-0.9-1.2-1.0-1.0-0.8-1.1-1.2-1.2
BMI with tail6.120.926.22.5-5.0-4.8-4.3-4.8-5.1-4.7-4.7-4.7
BMI without tail3.09.211.91.4-3.1-3.2-3.2-2.9-3.2-3.4-3.2-3.2
Body weight2.310.213.33.7-3.3-3.0-3.5-2.9-3.2-3.0-3.0-3.1
Weight adjusted by age0.20.32.61.6-0.2-0.2-0.0-0.1-0.2-0.3-0.1-0.1
Bone surface3.97.09.83.1-2.8-3.0-1.7-2.9-2.3-3.0-2.6-2.1
Bone volume2.64.66.31.9-2.4-2.5-1.2-2.5-2.1-2.4-2.2-1.8
Breakpoint value in progressive ratio session1.41.75.52.4-1.3-1.0-1.0-1.1-1.2-1.0-1.0-1.0
Number of licking bursts0.10.10.70.8-0.4-0.2-0.1-0.4-0.20.0-0.2-0.2
Context. condit. distance diff. score0.40.53.0-1.70.50.70.20.40.10.20.30.1
Locomotion velocity, session 10.20.20.5-0.20.60.5-0.20.70.40.60.50.3
Locomotion distance, session 12.12.73.70.6-1.6-1.8-1.9-1.5-1.8-1.7-1.8-1.6
Locomotion velocity, session 22.32.63.71.9-1.6-1.6-1.9-1.4-1.6-1.3-1.5-1.6
Locomotion distance, session 21.82.54.00.8-1.5-1.9-2.0-1.4-1.6-1.6-1.6-1.6
Locomotion velocity, session 30.60.71.3-0.4-0.8-0.7-1.0-0.8-1.0-0.3-0.9-1.1
Locomotion distance, session 30.00.00.1-0.1-0.00.1-0.10.00.00.30.1-0.0
Stereotopy head waving bouts, day 30.60.71.2-1.1-0.6-0.7-0.9-0.6-0.9-0.8-0.9-1.0
Stereotopy head waving duration, day 30.30.31.4-1.2-0.3-0.4-0.2-0.5-0.4-0.5-0.6-0.5
Locomotion velocity, session 71.82.02.9-0.4-1.4-1.3-1.2-1.4-1.7-1.7-1.5-1.7
Locomotion distance, session 70.91.12.0-0.2-0.9-0.7-1.4-0.7-1.1-1.3-1.1-1.3
Stereotopy head waving bouts, day 70.30.40.90.1-0.8-0.80.1-1.0-0.6-0.4-0.6-0.5
Stereotopy head waving duration, day 71.11.32.31.1-1.4-1.4-0.5-1.5-1.1-0.9-1.2-1.0
Locomotion velocity, session 80.10.20.70.80.20.0-0.70.30.2-0.30.00.3
Locomotion distance, session 80.30.50.9-0.5-0.6-0.5-0.8-0.6-0.9-0.6-0.6-0.8
Degree of sensitization distance1.21.22.5-0.0-0.9-1.0-1.2-0.9-1.1-1.6-1.2-1.2
Degree of sensitization stereotypy0.50.61.11.0-1.0-0.80.0-1.1-0.7-0.3-0.6-0.6
Conditioned locomotion0.30.41.91.4-0.4-0.2-0.8-0.2-0.3-0.4-0.2-0.4
Cocaine response after cond. corrected0.40.52.2-1.50.70.70.00.80.40.60.40.2
Cocaine response after cond. not corrected0.30.31.5-1.20.60.50.10.60.40.60.30.1
Cocaine response before conditioning0.20.31.51.2-0.6-0.50.1-0.6-0.40.0-0.3-0.2
Saline control response1.31.74.82.2-1.0-1.2-1.6-0.8-0.7-1.4-1.2-0.8
Bone: connectivity density4.16.310.71.9-2.6-2.9-2.0-2.6-2.3-3.3-2.7-2.1
Bone: cortical apparent density0.20.21.00.40.30.40.00.40.31.00.60.3
Bone: cortical area0.20.22.01.4-0.30.0-0.0-0.2-0.2-0.00.1-0.1
Bone: cortical porosity0.50.61.00.3-0.8-1.0-0.7-0.8-0.7-0.5-0.9-0.7
Bone: cortical porosity0.80.81.30.6-0.9-1.1-0.9-0.9-0.9-0.7-1.0-0.9
Bone: cortical thickness0.61.05.82.40.40.7-0.50.80.50.70.70.5
Bone: cortical thickness0.30.40.90.60.60.7-0.50.90.60.70.50.4
Bone: cortical tissue density0.20.20.90.50.30.4-0.00.40.31.00.50.3
Condit. Reinf. active minus inactive responses0.50.50.70.5-0.8-0.8-0.8-0.6-0.7-0.6-0.8-0.8
Condit. Reinf. active-inactive response ratio0.10.10.10.2-0.3-0.3-0.3-0.2-0.2-0.2-0.3-0.3
Condit. Reinf. active responses0.50.60.90.4-0.9-0.8-0.7-0.7-0.9-0.6-0.7-0.9
Condit. Reinf. inactive responses0.30.40.80.0-0.7-0.5-0.4-0.6-0.9-0.4-0.6-0.8
Incentive salience index mean1.21.52.00.7-1.3-1.2-1.3-1.1-1.4-1.2-1.3-1.4
Condit. Reinf. lever presses0.71.01.61.1-1.1-0.7-0.8-1.0-1.3-1.0-0.8-1.2
Condit. Reinf. active minus inactive responses0.10.10.3-0.0-0.4-0.40.5-0.5-0.2-0.5-0.3-0.0
Condit. Reinf. active-inactive response ratio0.10.20.9-0.4-0.2-0.11.0-0.4-0.1-0.10.0-0.0
Condit. Reinf. active responses0.60.81.50.4-1.0-1.2-0.3-1.2-0.9-1.2-1.0-0.5
Condit. Reinf. inactive responses1.11.42.20.5-1.2-1.5-1.4-1.2-1.2-1.3-1.4-0.9
Condit. Reinf. lever presses1.11.64.22.0-1.4-1.3-0.4-1.4-1.0-1.4-1.0-0.7
Condit. Reinf. lever reinforcers received0.60.81.40.7-1.0-1.1-0.3-1.2-0.9-1.2-0.9-0.4
Conditioned reinforcement - actives0.50.83.30.30.60.61.80.50.80.70.81.0
Conditioned reinforcement - inactives1.62.47.4-1.71.21.22.71.01.41.11.31.5
Conditioned locomotion4.25.510.1-3.22.12.13.21.82.11.92.12.1
Patch foraging indifference point 0 sec0.00.10.1-0.2-0.3-0.2-0.2-0.4-0.4-0.1-0.3-0.3
Patch foraging indifference point AUC0.40.64.42.1-0.5-0.3-0.1-0.4-0.2-0.2-0.1-0.0
Delay disc. indifference point, 0s delay1.01.01.4-1.0-0.9-1.1-1.0-1.0-0.8-1.1-1.1-1.2
Delay disc. indifference point, 16s delay0.20.20.5-0.7-0.5-0.50.1-0.6-0.3-0.3-0.4-0.4
Delay disc. indifference point, 2s delay0.10.20.2-0.4-0.4-0.5-0.1-0.5-0.2-0.4-0.4-0.4
Delay disc. indifference point, 24s delay0.10.10.2-0.40.40.3-0.20.50.40.20.10.1
Delay disc. indifference point, 4s delay0.70.71.1-0.6-0.6-0.9-1.1-0.6-0.6-1.0-1.0-1.1
Delay disc. indifference point, 8s delay0.50.50.9-0.4-0.5-0.8-0.9-0.6-0.5-0.9-0.9-0.9
Indifference point function ln k1.83.214.7-3.81.71.60.81.71.11.31.20.8
Indifference point function log k1.83.214.7-3.81.71.60.81.71.11.31.20.8
Patch foraging total patch changes 0 sec0.00.00.1-0.10.20.2-0.20.20.00.30.10.1
Patch foraging total patch changes 12 sec2.22.87.12.7-1.7-1.5-1.7-1.5-1.6-1.4-1.4-1.3
Patch foraging total patch changes 18 sec0.50.71.11.0-1.0-1.0-0.6-1.0-0.8-0.7-0.8-0.8
Patch foraging total patch changes 24 sec0.20.32.91.7-0.1-0.0-0.3-0.0-0.0-0.1-0.00.2
Patch foraging total patch changes 6 sec0.71.11.71.3-1.0-1.0-1.3-0.8-0.9-1.0-1.1-0.9
Patch foraging time to switch 0 sec3.16.38.21.9-2.8-2.9-1.9-2.8-2.6-2.4-2.5-2.5
Patch foraging water rate 0 sec4.39.111.3-2.73.33.42.73.22.92.83.03.0
Patch foraging water rate 12 sec6.112.718.6-4.34.03.52.83.83.73.03.33.4
Patch foraging water rate 18 sec2.03.26.0-2.52.01.71.02.01.81.71.51.5
Patch foraging water rate 24 sec4.56.48.0-2.82.82.72.02.72.42.42.52.2
Patch foraging water rate 6 sec4.76.99.6-2.93.12.81.73.12.82.32.42.4
Seeking ratio, delayed vs. immediate footshock0.60.81.3-0.3-0.9-1.0-0.6-0.9-0.9-0.7-1.0-1.1
Distance traveled before self-admin0.81.01.61.0-1.2-1.2-0.4-1.3-1.0-0.9-0.9-0.9
Distance traveled after self-admin0.10.10.40.6-0.3-0.3-0.1-0.4-0.2-0.2-0.2-0.2
Extensor digitorum longus weight2.811.136.06.0-3.0-2.2-3.7-2.4-2.9-2.8-2.4-2.9
Bone: elastic displacement2.73.25.0-1.12.12.01.02.21.91.71.81.8
Bone: elastic work0.30.41.01.00.50.6-0.80.80.40.20.40.3
Bone: endosteal estimation0.81.72.9-1.2-1.2-1.3-0.4-1.4-1.3-1.7-1.4-1.4
Bone: endosteal perimeter0.81.73.2-1.2-1.2-1.30.2-1.5-1.2-1.8-1.3-1.2
Epididymis fat weight1.13.810.9-3.31.51.82.71.11.21.71.71.3
Delta time in closed arm before/after self-admin0.30.21.60.00.1-0.2-1.30.3-0.1-0.4-0.3-0.3
Delta time in open arm before/after self-admin0.20.20.90.8-0.10.11.0-0.20.10.30.30.3
Diff in mean of infusions in LGA sessions0.10.10.90.9-0.0-0.1-0.30.00.1-0.1-0.00.1
Delay discount exponential model param0.70.81.10.20.81.00.90.80.71.01.11.1
Extinction: sum of active levers before priming2.83.13.92.0-1.9-1.7-1.6-1.7-1.8-1.7-1.6-1.7
Active lever presses in extinction session 60.60.64.72.2-0.6-0.2-0.1-0.6-0.4-0.0-0.2-0.2
Bone: final force1.01.74.72.2-1.2-1.1-1.1-1.1-1.1-1.4-1.0-1.0
Bone: final moment1.01.54.22.0-1.2-1.1-1.1-1.0-1.1-1.3-1.0-1.0
Food consumed during 24 hour testing period0.71.01.50.30.91.11.20.81.11.11.11.2
Glucose0.91.44.6-2.1-0.8-1.2-0.5-1.0-1.0-0.7-1.1-1.3
Heart weight1.72.73.4-1.6-1.4-1.8-1.8-1.4-1.4-1.6-1.8-1.8
Delay discount hyperbolic model param0.70.81.10.30.81.00.80.90.71.01.11.1
Intermittent access intake day 1-15 change1.02.04.7-1.11.21.32.21.11.31.41.41.4
Intermittent access intake escalation1.02.15.2-0.91.31.42.31.11.31.41.51.5
Intermittent access intake escalation 21.71.94.4-0.91.21.42.11.01.21.51.51.4
Intermitt. access day 1 inactive lever presses0.00.10.3-0.30.30.40.60.30.30.30.40.3
Intermitt. access day 15 inactive lever presses0.30.62.9-1.20.30.31.70.20.50.20.50.7
Intermitt. access escalation Index0.50.65.3-2.30.40.20.40.20.20.10.20.2
Intermittent access day 1 total infusions0.91.53.2-1.8-1.2-1.40.4-1.4-0.9-1.4-1.2-0.8
Intermittent access day 15 total infusions1.31.97.1-2.40.70.62.70.41.00.60.81.1
Intermittent access terminal intake (last 3 days)0.91.25.3-2.10.20.12.3-0.10.50.20.40.7
Intermittent access total infusions0.60.83.4-1.9-0.4-0.61.4-0.6-0.1-0.6-0.40.1
Intermittent access day 1 locomotion0.60.82.4-1.6-0.7-0.90.4-0.9-0.6-1.1-0.8-0.5
Intermittent access day 15 total locomotion0.71.36.3-2.00.30.32.50.00.60.40.50.8
Intermittent access total locomotion1.11.36.2-2.5-0.2-0.22.3-0.60.0-0.2-0.00.3
Intermittent access standard deviation0.81.73.5-1.31.21.11.91.11.31.01.21.4
Left kidney weight0.10.43.0-1.70.10.20.6-0.1-0.3-0.00.3-0.1
Right kidney weight0.21.01.5-1.20.91.21.10.80.71.11.10.7
Cocaine induced anxiety0.00.00.20.3-0.20.10.5-0.2-0.10.10.1-0.0
Post-drug Anxiety0.20.21.21.1-0.4-0.2-0.1-0.4-0.3-0.1-0.1-0.3
Baseline Anxiety0.10.10.50.50.2-0.0-0.70.20.10.20.10.1
Tail length0.10.51.11.00.80.7-0.41.00.80.30.60.6
Length with tail0.31.17.92.8-0.10.1-1.30.20.1-0.10.0-0.1
Length without tail0.30.96.02.40.10.3-1.20.40.20.40.20.2
Times rat made contact with spout0.60.61.40.5-0.7-0.9-1.0-0.6-0.5-1.2-0.9-0.6
Lifetime Intake0.50.62.7-1.6-0.5-0.70.9-0.6-0.2-0.8-0.5-0.1
Liver weight, left0.50.92.0-1.41.10.90.51.10.80.90.80.7
Liver weight, right0.91.55.9-2.41.31.10.41.31.00.90.80.8
Locomotor activity2.13.34.8-2.12.11.81.12.21.91.51.61.7
Locomotor testing distance2.24.06.1-2.52.41.91.12.42.21.51.71.9
Locomotor testing rearing1.12.26.6-2.61.70.90.81.61.70.60.91.4
Locomotion in novel chamber1.92.47.1-2.71.31.22.01.01.21.31.31.3
Locomotion in novel chamber post-restriction0.81.33.9-2.00.80.81.70.60.91.00.90.8
Fecal boli incidents, locomotor time 10.10.21.20.5-0.00.21.1-0.20.20.40.30.1
Change in fecal boli incidents, locomotor task0.40.41.5-0.3-0.4-0.6-1.2-0.3-0.6-0.7-0.7-0.6
Time >=10cm from walls, locomotor time 10.90.92.0-0.5-1.2-1.10.4-1.4-1.1-0.9-0.9-0.9
Bouts of movement, locomotor time 10.30.32.41.5-0.2-0.2-0.0-0.30.00.1-0.1-0.4
Total resting periods, locomotor time 10.20.31.81.3-0.3-0.30.1-0.4-0.1-0.0-0.1-0.4
Rest time, locomotor task time 11.21.52.3-1.31.21.31.51.01.21.21.21.0
Distance moved, locomotor task time 10.91.41.80.3-1.3-1.3-1.2-1.2-1.3-1.3-1.3-1.0
Vertical activity count, locomotor time 10.10.21.2-1.10.30.30.30.40.20.20.10.2
Time >=10cm from walls, locomotor time 20.10.10.20.4-0.3-0.20.4-0.4-0.4-0.10.0-0.1
Bouts of movement, locomotor time 20.20.40.70.9-0.6-0.7-0.4-0.6-0.4-0.5-0.6-0.7
Total resting periods, locomotor time 20.20.40.60.6-0.7-0.7-0.4-0.7-0.5-0.6-0.6-0.7
Rest time, locomotor task time 20.60.73.0-1.70.70.70.90.50.70.60.50.2
Distance moved, locomotor task time 20.20.21.71.3-0.3-0.2-0.5-0.1-0.2-0.1-0.10.1
Vertical activity count, locomotor time 21.01.42.6-0.11.41.40.51.61.21.31.21.2
Light reinforcement 10.10.20.5-0.50.50.30.40.50.50.30.40.7
Light reinforcement 20.61.03.4-0.70.70.91.80.50.90.51.01.2
Bone: marrow area0.91.93.2-1.3-1.2-1.3-0.5-1.4-1.4-1.8-1.5-1.5
Bone: maximum diameter0.10.10.60.8-0.10.30.7-0.20.0-0.00.20.2
Bone: maximum force2.85.07.62.8-2.4-2.2-1.8-2.3-2.3-2.3-2.0-2.1
Bone: maximum moment2.64.66.82.6-2.3-2.1-1.7-2.2-2.2-2.1-2.0-2.0
Mean time between licks in bursts0.00.10.70.20.30.1-0.80.40.20.0-0.1-0.1
Mean num. licks in bursts0.10.20.6-0.80.1-0.3-0.30.1-0.1-0.7-0.20.1
Cd content in liver0.60.62.0-1.00.40.51.40.10.51.00.60.7
Co content in liver2.73.24.6-1.52.12.10.92.21.81.71.81.6
Cu content in liver0.40.50.90.1-0.8-0.6-0.5-0.7-1.0-0.5-0.7-0.8
Fe content in liver0.20.20.30.40.50.50.20.50.50.30.40.6
K content in liver1.11.11.80.6-1.1-0.8-1.4-0.9-1.1-1.0-1.1-1.2
Mg content in liver0.20.30.5-0.7-0.4-0.3-0.7-0.3-0.6-0.1-0.5-0.6
Mn content in liver0.80.95.52.3-0.9-0.4-0.5-0.8-0.7-0.3-0.4-0.3
Na content in liver0.50.60.90.80.71.00.40.70.60.90.90.7
Rb content in liver0.40.43.3-1.80.2-0.3-0.00.20.0-0.4-0.20.2
Se content in liver0.10.10.8-0.1-0.0-0.10.9-0.10.1-0.00.10.4
Sr content in liver0.60.52.71.60.20.80.10.20.30.80.60.5
Zn content in liver0.30.40.60.5-0.6-0.4-0.8-0.5-0.8-0.5-0.6-0.6
Bone: minimum diameter1.63.04.5-0.9-1.7-2.0-0.8-1.9-1.9-2.1-1.9-1.8
Time in familiar zone, hab. session 10.20.20.3-0.4-0.4-0.4-0.2-0.5-0.5-0.2-0.4-0.5
Time in novel zone, hab. session 10.90.91.4-0.71.21.10.41.21.10.70.80.9
Total zone transitions, hab. session 10.70.91.31.2-1.0-0.9-0.9-0.9-1.1-0.9-0.8-0.8
Total locomotion distance, hab. session 10.20.30.8-0.5-0.5-0.4-0.5-0.6-0.9-0.4-0.4-0.7
Locomotion velocity, hab. session 10.30.51.0-0.0-0.7-0.6-0.7-0.7-1.0-0.7-0.6-0.8
Time in familiar zone, hab. session 20.40.40.9-0.30.80.6-0.20.90.60.60.60.6
Time in novel zone, hab. session 20.70.71.20.3-1.0-1.0-0.4-1.1-0.8-1.0-0.9-0.9
Total zone transitions, hab. session 25.36.810.11.1-2.7-3.2-2.6-2.7-2.6-2.8-2.9-2.5
Total locomotion distance, hab. session 22.33.14.0-0.2-1.7-2.0-1.8-1.7-2.0-1.6-1.9-2.0
Locomotion velocity, hab. session 22.12.83.7-0.3-1.7-1.9-1.5-1.7-1.9-1.6-1.8-1.9
Novel to familiar place preference ratio0.70.82.01.4-1.1-0.8-0.1-1.2-0.7-0.6-0.6-0.6
Novelty place preference0.50.51.11.0-0.9-0.70.1-1.1-0.6-0.5-0.5-0.5
Time in novel zone, NPP test0.40.40.90.8-0.8-0.70.0-0.9-0.5-0.5-0.5-0.4
Total zone transitions, NPP test2.53.64.01.8-1.9-2.0-1.9-1.8-1.9-2.0-1.9-1.7
Total locomotion distance, NPP test1.21.62.30.2-1.2-1.3-1.4-1.1-1.5-1.5-1.3-1.4
Locomotion velocity, NPP test1.11.52.20.4-1.2-1.2-1.3-1.1-1.5-1.5-1.2-1.4
Intraocular pressure2.43.56.9-1.01.71.82.61.41.82.02.02.1
Delta distance traveled before/after self-admin0.50.51.0-0.50.90.90.01.00.80.60.70.7
Delta ambulatory time before/after self-admin0.30.40.8-0.30.80.8-0.10.90.70.50.60.6
Parametrial fat weight0.51.28.4-2.90.30.51.3-0.00.10.50.40.1
Pavlov. Cond. lever latency0.50.60.7-0.60.80.70.80.80.90.70.70.9
Pavlov. Cond. magazine entry latency1.41.82.40.7-1.5-1.4-1.1-1.6-1.6-1.3-1.3-1.5
Pavlov. Cond. change in total contacts0.60.61.20.7-1.0-0.7-0.1-1.1-1.0-0.4-0.6-0.9
Pavlov. Cond. index score0.20.30.50.7-0.6-0.4-0.3-0.6-0.6-0.3-0.3-0.6
Pavlov. Cond. latency score0.30.40.60.5-0.7-0.5-0.6-0.7-0.8-0.5-0.5-0.8
Pavlov. Cond. lever contacts0.50.60.80.4-0.8-0.7-0.8-0.7-0.9-0.7-0.7-0.9
Pavlov. Cond. magazine entry number0.10.10.8-0.90.40.2-0.10.40.3-0.1-0.00.2
Pavlov. Cond. intertrial magazine entries0.60.71.6-0.50.80.81.30.80.90.80.81.0
Pavlov. Cond. lever-magazine prob. diff.0.50.60.80.9-0.9-0.7-0.5-0.9-0.9-0.5-0.6-0.9
Pavlov. Cond. response bias0.10.10.60.8-0.4-0.1-0.0-0.4-0.40.1-0.1-0.3
Pavlov. Cond. lever latency0.10.21.4-1.20.30.1-0.30.30.10.20.0-0.0
Pavlov. Cond. magazine entry latency3.34.07.12.7-2.1-2.2-1.6-1.9-1.9-1.8-1.8-1.7
Pavlov. Cond. change in total contacts1.11.84.52.1-1.6-1.3-0.2-1.7-1.2-1.0-1.0-1.0
Pavlov. Cond. index score1.62.15.42.3-1.6-1.5-0.7-1.6-1.3-1.3-1.2-1.2
Pavlov. Cond. latency score1.41.84.82.2-1.5-1.3-0.6-1.4-1.3-1.2-1.1-1.1
Pavlov. Cond. lever contacts0.20.21.41.2-0.4-0.30.3-0.4-0.1-0.2-0.1-0.1
Pavlov. Cond. magazine entry number3.74.612.1-3.52.32.21.52.11.91.81.81.5
Pavlov. Cond. intertrial magazine entries0.50.81.7-1.30.81.01.00.70.90.80.70.7
Pavlov. Cond. lever-magazine prob. diff.1.92.56.32.5-1.7-1.6-0.8-1.7-1.4-1.4-1.3-1.2
Pavlov. Cond. response bias1.11.54.22.0-1.3-1.3-0.6-1.3-1.0-1.0-1.0-0.8
Time in closed arm before self-admin0.10.10.4-0.4-0.3-0.20.6-0.5-0.3-0.0-0.2-0.2
Time in closed arm after self-admin0.00.00.3-0.50.00.1-0.30.1-0.1-0.0-0.1-0.1
Time in open arm before self-admin0.40.41.3-0.90.60.3-1.20.90.40.10.10.0
Time in open arm after self-admin0.00.00.10.10.30.1-0.20.30.30.20.20.2
Bone: periosteal estimation0.30.61.10.2-0.9-0.7-0.1-0.9-0.9-1.0-0.7-0.9
Bone: periosteal perimeter0.40.81.40.6-1.0-0.7-0.3-1.1-0.9-1.2-0.9-0.9
Bone: post-yield work9.313.719.31.3-4.3-4.1-2.4-4.4-4.3-3.5-3.8-4.0
Progressive ratio test 1 active lever presses0.10.10.6-0.4-0.1-0.20.8-0.10.2-0.3-0.10.3
Progressive ratio test 1 breakpoint0.10.10.7-0.3-0.1-0.20.8-0.10.2-0.3-0.10.3
Progressive ratio test 1 inactive lever presses0.10.10.5-0.20.10.00.70.00.2-0.20.10.3
Progressive ratio test 2 active lever presses0.70.84.1-1.40.40.22.00.20.70.20.40.8
Progressive ratio test 2 breakpoint0.80.94.3-1.40.50.32.10.30.70.30.50.9
Progressive ratio test 2 inactive lever presses1.72.79.3-3.10.90.83.00.61.10.71.01.3
Incentive Sensitization - Responses0.30.40.80.1-0.8-0.80.2-0.8-0.6-0.9-0.7-0.5
Incentive Sensitization - Breakpoint0.20.30.6-0.1-0.6-0.70.3-0.7-0.5-0.8-0.5-0.4
Sum of active levers in priming session hrs 5-63.33.05.11.71.31.82.31.31.61.91.91.8
Progressive ratio3.65.67.41.1-2.7-2.7-1.9-2.7-2.4-2.3-2.6-2.4
Food seeking constrained by brief footshock0.00.10.20.3-0.0-0.2-0.40.10.0-0.3-0.3-0.2
Seeking ratio, punishment vs. effort2.53.65.7-1.52.32.11.12.42.01.61.91.8
Retroperitoneal fat weight2.510.748.0-6.92.82.53.32.32.21.82.22.2
Reaction time number correct0.30.61.30.60.70.80.30.80.81.10.80.7
Reaction time mean minus median0.71.86.92.6-1.4-1.1-0.5-1.4-1.2-0.4-1.0-1.2
Reaction time mean minus median AUC0.20.53.61.9-0.5-0.20.0-0.4-0.30.5-0.0-0.3
Reaction time num false alarms0.30.51.2-0.80.81.0-0.51.10.40.20.50.2
Reaction time num false alarms AUC0.10.20.8-0.10.40.7-0.90.70.1-0.00.2-0.1
Reaction time trials correct on left0.30.61.30.60.70.80.30.80.81.10.80.7
Reaction time trials on left0.30.71.40.70.80.90.30.80.81.20.90.7
Reaction time mean0.10.10.30.5-0.4-0.20.4-0.5-0.10.6-0.0-0.2
Reaction time mean AUC0.10.20.40.4-0.5-0.30.4-0.6-0.30.5-0.1-0.4
Median of all reaction times0.10.10.2-0.2-0.2-0.20.5-0.4-0.00.50.0-0.1
Reaction time omissions0.60.83.71.9-0.9-0.6-0.6-0.7-0.7-0.2-0.6-0.8
Reaction time false alarm rate0.10.20.5-0.70.30.4-0.70.5-0.1-0.4-0.1-0.2
Reaction time premature initiation rate0.50.73.01.5-0.3-0.4-1.7-0.0-0.3-0.4-0.6-0.5
Reaction time premature initiations0.40.84.32.10.20.1-1.40.50.20.3-0.1-0.0
Std. dev. reaction times0.30.52.21.5-0.8-0.50.0-0.8-0.50.2-0.4-0.5
Reaction time trials completed0.30.71.40.70.80.90.30.80.81.20.90.7
Reaction time trials AUC0.30.61.30.50.80.90.20.80.81.10.80.6
Run reversals in cocaine runway, females2.32.35.10.4-1.5-1.4-2.3-1.3-1.7-1.3-1.5-1.7
Run reversals in cocaine runway, males3.13.14.0-0.51.92.01.52.01.81.91.91.7
Latency to leave start box in cocaine runway0.91.01.6-0.1-1.2-1.1-0.7-1.2-1.3-0.9-1.0-1.0
Latency to leave start box in cocaine runway, F0.60.71.0-0.1-1.0-1.0-0.6-1.0-1.0-0.7-0.9-0.9
Latency to leave start box in cocaine runway, M0.20.20.30.3-0.5-0.4-0.4-0.5-0.6-0.4-0.3-0.4
Std. dev. time between licks in bursts0.30.51.2-0.50.90.8-0.41.10.50.70.60.4
Total sessions with >9 infusions1.01.22.50.0-1.2-1.3-0.5-1.2-1.0-1.6-1.3-1.0
Short access day 1 total inactive lever presses0.40.53.1-1.80.50.30.60.40.40.20.30.4
Short access day 10 total inactive lever presses0.10.20.6-0.80.40.40.10.50.30.20.30.3
Short access day 1 total infusions0.40.62.0-1.4-0.6-0.60.1-0.7-0.5-0.9-0.7-0.5
Short access day 10 total infusions2.53.25.5-0.5-2.0-2.2-0.6-2.1-1.7-2.3-2.0-1.6
Short access total infusions1.01.32.6-0.6-1.2-1.4-0.4-1.2-1.0-1.6-1.3-1.0
Short access day 1 locomotion0.30.31.7-1.3-0.3-0.40.6-0.3-0.1-0.6-0.4-0.1
Short access day 10 total locomotion0.30.50.9-0.9-0.7-0.70.5-0.8-0.5-0.9-0.6-0.4
Short access total locomotion0.40.41.3-1.2-0.5-0.60.6-0.6-0.4-0.8-0.5-0.3
One hour access (0.3 mA shock)2.12.48.3-2.91.20.92.20.91.30.91.01.3
Compulsive drug intake0.40.52.61.10.50.3-1.60.70.30.10.10.0
One hour access (shock baseline)1.72.58.6-2.80.90.92.90.51.00.91.01.2
Social response proportion0.20.30.91.0-0.6-0.5-0.1-0.6-0.4-0.1-0.4-0.2
Social responses0.10.10.20.40.20.20.10.30.40.50.20.4
Social time0.10.10.20.50.40.40.00.40.50.30.30.4
Soleus weight1.54.314.3-3.82.01.92.01.81.51.41.81.5
Bone: stiffness2.64.25.22.3-2.3-2.1-1.4-2.3-2.0-2.1-1.9-1.8
Tibialis anterior weight1.75.742.16.5-1.3-0.5-2.0-0.8-1.0-0.8-0.5-0.9
Time to tail flick, vehicle, before self-admin0.60.60.90.4-0.9-0.9-0.5-0.9-0.8-0.9-0.8-0.8
Time to tail flick, vehicle, after self-admin2.73.64.70.5-1.9-2.0-2.2-1.8-2.0-1.8-2.0-2.1
Time to tail flick, test, before self-admin1.01.02.6-1.6-0.7-1.1-0.7-0.7-0.9-1.0-1.1-0.9
Time to tail flick, test, after self-admin0.10.10.40.30.20.30.60.10.30.30.40.4
Delta time to tail flick, vehicle, before/after SA1.11.01.90.4-1.0-1.1-1.4-0.9-1.0-0.8-1.1-1.1
Delta time to tail flick, test, before/after SA2.82.93.61.61.51.91.71.51.71.81.91.8
Tibia length0.41.05.32.3-0.10.11.2-0.10.30.90.80.7
Ambulatory time before self-admin0.60.91.71.0-1.2-1.1-0.1-1.3-1.0-0.8-0.8-0.8
Ambulatory time after self-admin0.10.20.5-0.2-0.5-0.40.2-0.7-0.4-0.3-0.4-0.4
Bone: tissue strength0.10.10.20.1-0.4-0.4-0.1-0.4-0.4-0.4-0.3-0.2
Total heroin consumption1.72.07.42.7-1.3-1.2-1.4-1.2-1.1-0.9-1.0-1.1
Bone: trabecular number2.33.75.81.2-2.2-2.3-1.1-2.2-1.9-2.4-2.1-1.5
Bone: trabecular spacing0.40.51.0-1.00.90.70.00.90.61.00.60.3
Bone: trabecular thickness0.50.60.9-0.5-0.9-0.8-0.3-0.9-0.8-0.8-1.0-0.7
Bone: trabecular tissue density2.53.75.8-2.41.92.02.21.81.71.72.01.7
Water consumed over 24 hours0.20.21.11.0-0.3-0.5-0.5-0.20.0-0.4-0.30.1
Number of responses in last shaping day0.10.10.2-0.30.50.40.00.50.50.10.30.4