Hub : Genes

Impa1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Impa1 0.07 0.06 2.5e-04 0.05 0.05 0.05 0.05 3.9e-05 1.0e-04 4.2e-05 3.9e-05
2 LHb mRNA stability Impa1 0.48 0.19 7.0e-06 0.1 0.04 0.1 0.09 2.2e-03 4.8e-02 2.3e-03 4.2e-03
3 BLA mRNA stability Impa1 0.07 0.06 4.3e-03 0.02 0.01 0.01 0.01 4.0e-02 6.7e-02 1.1e-01 6.7e-02
4 NAcc mRNA stability Impa1 0.11 0.08 4.2e-10 0.05 0.05 0.06 0.02 7.8e-08 1.1e-08 2.3e-09 2.6e-04
5 IL mRNA stability Impa1 0.35 0.18 8.4e-04 0.09 0.03 0.06 -0 4.4e-03 7.8e-02 1.7e-02 3.4e-01
6 pVTA mRNA stability Impa1 0.07 0.04 2.8e-05 0.05 0.04 0.05 0 7.4e-05 2.7e-04 8.5e-05 2.5e-01
7 Adipose mRNA stability Impa1 0.48 0.31 0.0e+00 0.14 0.14 0.14 0.14 2.6e-15 1.3e-15 3.6e-15 2.7e-15
8 PL mRNA stability Impa1 0.15 0.08 1.8e-12 0.1 0.09 0.09 0.1 6.0e-11 4.5e-10 3.9e-10 7.6e-11
9 Brain mRNA stability Impa1 0.32 0.14 0.0e+00 0.08 0.11 0.11 0.1 2.8e-08 4.0e-10 3.9e-10 1.2e-09
10 Eye isoform ratio XM_006232151.5 0.33 0.19 4.8e-03 0.06 0.06 0.04 0.06 5.1e-02 4.6e-02 9.4e-02 4.7e-02
11 BLA gene expression Impa1 0.07 0.06 9.3e-03 -0 -0 -0 -0 4.1e-01 5.2e-01 6.1e-01 9.8e-01
12 Liver mRNA stability Impa1 0.09 0.06 1.4e-07 0.05 0.05 0.05 0.05 3.8e-06 3.1e-06 2.6e-06 2.5e-06
13 Liver intron excision ratio chr2_93377686_93378734 0.04 0.03 1.7e-03 0 0.01 0.01 0.01 3.3e-01 6.9e-03 1.9e-02 4.5e-02
14 Liver intron excision ratio chr2_93378842_93380358 0.05 0.04 6.5e-04 0 0.02 0.01 0.01 2.1e-01 2.9e-03 8.6e-03 1.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.72.94.4-1.3-1.4-1.4-1.8-2.1-1.8-1.9-1.8-1.81.91.7-1.91.4-1.4
Area under the delay curve1.11.32.10.91.01.01.31.41.21.21.21.1-1.2-1.21.1-1.01.0
BMI with tail0.41.53.01.61.41.71.41.31.21.31.31.2-1.1-1.01.1-0.20.2
BMI without tail0.72.04.41.81.92.11.71.51.11.51.51.3-1.3-1.21.1-0.10.0
Body weight0.41.95.62.32.42.21.61.00.91.11.11.0-0.9-1.00.60.8-0.8
Weight adjusted by age0.10.20.50.20.60.70.3-0.30.1-0.1-0.50.30.1-0.1-0.00.7-0.7
Bone surface4.17.512.0-1.9-1.8-1.8-2.6-3.5-2.8-2.9-3.0-2.83.02.9-3.12.8-2.7
Bone volume3.86.911.1-1.7-1.6-1.6-2.5-3.3-2.8-2.8-3.0-2.62.92.6-3.02.8-2.7
Breakpoint value in progressive ratio session0.30.41.30.90.91.10.80.50.50.60.40.7-0.5-0.40.30.3-0.3
Number of licking bursts0.30.50.8-0.6-0.8-0.6-0.9-0.7-0.8-0.8-0.7-0.70.80.8-0.80.6-0.5
Context. condit. distance diff. score0.30.30.70.30.1-0.00.40.90.60.50.70.4-0.6-0.50.6-0.80.8
Locomotion velocity, session 11.61.73.21.81.71.61.61.21.51.31.21.4-1.3-1.21.1-0.20.2
Locomotion distance, session 10.40.51.81.31.31.20.80.20.40.50.40.5-0.4-0.30.10.7-0.7
Locomotion velocity, session 21.51.73.11.71.71.81.51.11.21.41.21.5-1.2-1.31.1-0.10.1
Locomotion distance, session 20.60.82.31.51.51.50.70.10.10.40.20.5-0.2-0.2-0.01.2-1.3
Locomotion velocity, session 30.00.10.30.10.1-0.00.10.50.20.20.10.2-0.2-0.30.3-0.30.3
Locomotion distance, session 30.50.50.9-0.5-0.5-0.4-0.7-0.5-0.9-0.8-0.9-0.80.80.8-0.80.8-0.8
Stereotopy head waving bouts, day 30.30.41.40.20.30.3-0.2-0.6-0.5-0.5-0.6-0.30.60.5-0.71.2-1.2
Stereotopy head waving duration, day 30.20.30.60.80.70.70.70.30.50.50.40.6-0.4-0.40.30.1-0.1
Locomotion velocity, session 77.98.610.9-1.8-2.1-2.2-3.1-2.9-3.3-3.2-3.1-3.33.33.3-3.32.9-2.9
Locomotion distance, session 74.75.97.9-2.3-2.5-2.6-2.8-2.3-2.7-2.7-2.5-2.82.62.6-2.51.4-1.4
Stereotopy head waving bouts, day 70.40.41.10.91.01.00.80.50.50.60.50.6-0.5-0.40.40.3-0.3
Stereotopy head waving duration, day 70.81.01.61.11.21.31.31.01.11.11.01.1-1.0-0.90.9-0.30.3
Locomotion velocity, session 83.44.05.52.32.32.22.32.22.12.12.02.1-2.0-2.12.0-0.80.8
Locomotion distance, session 80.81.12.51.61.41.21.21.31.01.01.10.9-0.9-0.90.9-0.00.0
Degree of sensitization distance0.30.30.6-0.5-0.6-0.8-0.7-0.8-0.6-0.6-0.4-0.70.50.5-0.60.2-0.2
Degree of sensitization stereotypy1.21.32.21.41.41.51.41.11.11.21.11.2-1.1-1.11.0-0.20.2
Conditioned locomotion0.10.10.20.50.40.40.40.10.20.30.20.4-0.3-0.30.20.0-0.0
Cocaine response after cond. corrected0.40.41.0-1.0-0.9-0.9-0.8-0.5-0.5-0.6-0.5-0.70.60.6-0.5-0.10.1
Cocaine response after cond. not corrected0.80.92.2-1.5-1.2-1.2-1.2-0.8-0.9-1.0-0.9-1.10.90.9-0.80.0-0.0
Cocaine response before conditioning0.40.50.8-0.7-0.5-0.4-0.7-0.6-0.9-0.8-0.9-0.70.80.7-0.70.7-0.7
Saline control response1.21.62.7-0.6-0.5-0.5-1.0-1.2-1.5-1.4-1.5-1.31.51.3-1.41.6-1.6
Bone: connectivity density1.82.93.7-1.4-1.7-1.8-1.8-1.9-1.7-1.9-1.7-1.91.81.8-1.81.1-1.1
Bone: cortical apparent density1.11.52.11.41.01.01.31.51.41.31.31.3-1.3-1.31.3-0.80.8
Bone: cortical area0.40.61.90.10.60.7-0.2-1.1-0.6-0.5-0.9-0.20.70.3-0.71.4-1.4
Bone: cortical porosity0.30.40.6-0.4-0.1-0.1-0.4-0.8-0.7-0.6-0.8-0.50.70.5-0.70.8-0.8
Bone: cortical porosity0.20.20.6-0.10.20.3-0.1-0.6-0.5-0.3-0.5-0.20.40.2-0.40.8-0.8
Bone: cortical thickness0.30.51.50.81.11.20.3-0.4-0.10.0-0.30.30.2-0.1-0.21.2-1.2
Bone: cortical thickness2.63.06.82.12.42.62.01.11.61.81.32.1-1.5-2.01.5-0.10.0
Bone: cortical tissue density1.21.62.31.41.01.01.31.51.41.31.41.3-1.4-1.41.4-0.90.9
Condit. Reinf. active minus inactive responses1.92.26.72.32.52.61.50.40.40.80.51.1-0.5-0.70.31.8-1.8
Condit. Reinf. active-inactive response ratio2.52.68.02.62.82.81.80.50.71.00.71.2-0.6-0.80.31.8-1.8
Condit. Reinf. active responses1.51.95.42.12.32.31.20.10.10.50.10.7-0.1-0.3-0.12.1-2.1
Condit. Reinf. inactive responses0.00.00.20.10.30.20.1-0.0-0.1-0.1-0.3-0.10.20.1-0.10.4-0.4
Incentive salience index mean1.92.47.12.52.72.71.50.50.50.80.51.1-0.5-0.60.21.9-1.9
Condit. Reinf. lever presses0.91.34.12.01.91.81.30.70.80.80.60.9-0.6-0.60.51.0-1.0
Condit. Reinf. active minus inactive responses4.55.87.8-1.6-1.3-1.3-2.2-2.7-2.6-2.6-2.8-2.52.72.6-2.82.7-2.7
Condit. Reinf. active-inactive response ratio2.73.14.8-1.0-0.8-0.7-1.5-2.0-1.9-1.8-2.0-1.82.01.9-2.12.2-2.2
Condit. Reinf. active responses5.88.111.3-2.0-1.6-1.6-2.6-3.4-3.0-3.0-3.3-3.03.23.0-3.33.0-3.0
Condit. Reinf. inactive responses0.50.61.1-0.5-0.3-0.4-0.6-1.0-0.8-0.8-0.9-0.80.90.8-0.90.9-0.9
Condit. Reinf. lever presses2.53.54.8-1.1-1.1-0.9-1.9-2.0-2.1-2.0-2.0-2.02.12.1-2.22.1-2.1
Condit. Reinf. lever reinforcers received6.08.311.6-2.1-1.7-1.6-2.7-3.4-3.1-3.1-3.3-3.03.23.0-3.33.0-3.0
Conditioned reinforcement - actives4.78.111.7-2.2-2.8-2.6-3.3-2.8-3.3-3.1-2.6-3.23.03.4-3.02.0-2.0
Conditioned reinforcement - inactives0.40.61.0-0.6-0.8-0.4-0.7-1.0-0.5-0.9-1.0-0.60.91.0-0.80.8-0.8
Conditioned locomotion3.34.27.1-1.3-2.2-1.9-2.4-1.9-2.3-2.3-1.7-2.32.22.7-2.11.6-1.6
Patch foraging indifference point 0 sec0.30.51.7-1.2-1.2-1.3-0.8-0.4-0.5-0.5-0.6-0.50.40.4-0.2-0.60.6
Patch foraging indifference point AUC0.30.40.60.50.60.40.60.40.70.60.60.7-0.7-0.80.7-0.50.5
Delay disc. indifference point, 0s delay0.10.10.3-0.2-0.4-0.5-0.20.1-0.0-0.10.2-0.3-0.00.20.0-0.40.4
Delay disc. indifference point, 16s delay0.91.01.70.80.90.91.11.31.01.11.11.0-1.1-1.10.9-0.80.8
Delay disc. indifference point, 2s delay0.40.41.31.10.90.80.4-0.1-0.10.00.1-0.00.10.2-0.31.1-1.1
Delay disc. indifference point, 24s delay0.20.30.50.00.40.50.60.70.30.50.40.6-0.5-0.60.5-0.50.5
Delay disc. indifference point, 4s delay2.22.33.21.41.41.41.71.81.81.61.51.6-1.6-1.61.6-1.01.0
Delay disc. indifference point, 8s delay0.40.51.0-0.10.10.40.60.80.70.70.50.7-0.7-0.80.7-1.01.0
Indifference point function ln k0.10.10.50.20.00.00.20.70.20.30.50.1-0.3-0.10.3-0.40.4
Indifference point function log k0.10.10.50.20.00.00.20.70.20.30.50.1-0.3-0.10.3-0.40.4
Patch foraging total patch changes 0 sec0.20.31.0-0.9-0.8-1.0-0.40.0-0.1-0.1-0.2-0.10.0-0.00.2-0.80.9
Patch foraging total patch changes 12 sec0.10.20.5-0.6-0.5-0.6-0.1-0.30.2-0.0-0.10.1-0.1-0.20.2-0.70.7
Patch foraging total patch changes 18 sec0.60.91.40.61.00.90.90.90.91.00.71.2-1.0-1.21.1-0.70.7
Patch foraging total patch changes 24 sec0.20.31.00.1-0.1-0.30.10.50.40.40.60.3-0.6-0.50.6-1.01.0
Patch foraging total patch changes 6 sec0.20.30.7-0.00.10.00.50.50.70.50.40.7-0.6-0.80.7-0.90.9
Patch foraging time to switch 0 sec0.40.93.21.51.41.80.80.4-0.00.20.10.20.00.1-0.21.5-1.5
Patch foraging water rate 0 sec0.30.61.9-0.4-0.2-0.70.40.30.90.50.60.6-0.7-0.90.7-1.41.4
Patch foraging water rate 12 sec0.61.23.0-1.7-1.4-1.7-1.3-0.9-1.0-1.0-1.0-1.10.90.8-0.9-0.20.2
Patch foraging water rate 18 sec0.20.30.6-0.8-0.7-0.7-0.6-0.8-0.5-0.6-0.5-0.60.50.5-0.60.1-0.1
Patch foraging water rate 24 sec0.50.82.2-0.2-0.1-0.20.41.00.70.71.00.6-0.9-0.90.9-1.51.5
Patch foraging water rate 6 sec1.21.84.4-1.8-1.8-2.1-1.5-1.2-1.2-1.4-1.3-1.41.21.1-1.10.1-0.0
Seeking ratio, delayed vs. immediate footshock5.26.311.1-3.3-3.3-3.3-2.9-2.6-2.3-2.7-2.5-2.52.42.4-2.00.4-0.3
Distance traveled before self-admin0.50.61.21.10.70.60.80.91.10.80.90.8-0.8-0.80.8-0.40.4
Distance traveled after self-admin0.00.00.1-0.4-0.3-0.3-0.10.00.1-0.1-0.1-0.10.0-0.00.1-0.30.3
Extensor digitorum longus weight6.927.350.57.16.96.66.34.95.15.45.25.3-4.9-4.94.3-0.70.6
Bone: elastic displacement0.60.72.10.10.20.3-0.4-0.6-0.9-0.7-0.8-0.70.90.9-0.91.5-1.5
Bone: elastic work0.91.23.0-0.2-0.00.1-0.7-1.2-1.2-1.0-1.2-1.01.21.2-1.31.7-1.7
Bone: endosteal estimation1.53.35.0-0.9-0.8-0.7-1.6-2.2-2.0-1.9-2.0-1.82.02.1-2.22.2-2.2
Bone: endosteal perimeter0.61.42.5-1.0-0.9-0.8-1.2-1.6-1.3-1.2-1.2-1.21.21.3-1.31.0-1.0
Epididymis fat weight0.41.43.41.31.21.11.11.31.01.31.81.0-1.3-1.21.1-0.90.9
Delta time in closed arm before/after self-admin0.20.20.6-0.0-0.3-0.4-0.10.30.20.30.70.0-0.4-0.20.4-0.80.8
Delta time in open arm before/after self-admin0.20.20.5-0.5-0.3-0.4-0.3-0.4-0.5-0.5-0.7-0.40.50.5-0.60.4-0.4
Diff in mean of infusions in LGA sessions0.60.72.41.21.41.60.80.2-0.10.40.20.5-0.2-0.2-0.11.1-1.1
Delay discount exponential model param1.01.11.7-0.8-0.8-0.9-1.2-1.3-1.1-1.1-1.1-1.11.11.1-1.00.9-0.9
Extinction: sum of active levers before priming0.10.10.40.20.50.60.2-0.5-0.2-0.1-0.40.10.2-0.1-0.20.6-0.6
Active lever presses in extinction session 60.10.10.4-0.5-0.3-0.2-0.00.30.00.10.10.2-0.2-0.20.3-0.60.6
Bone: final force0.40.62.20.20.60.8-0.2-1.1-0.7-0.4-0.8-0.20.70.4-0.81.5-1.5
Bone: final moment0.60.92.4-0.10.20.3-0.5-1.3-1.0-0.8-1.1-0.61.00.7-1.11.5-1.5
Food consumed during 24 hour testing period0.91.22.71.51.61.61.41.01.01.00.81.2-0.9-1.00.80.3-0.3
Glucose0.71.12.81.21.51.71.30.61.01.00.61.2-0.9-1.10.80.0-0.1
Heart weight0.61.01.50.70.70.60.91.21.11.01.10.9-1.1-1.11.1-0.90.9
Delay discount hyperbolic model param1.11.21.7-1.1-1.1-1.2-1.3-1.3-1.1-1.2-1.1-1.21.21.2-1.00.7-0.6
Intermittent access intake day 1-15 change1.53.04.9-2.2-2.1-2.1-2.0-1.8-2.0-1.8-1.6-1.71.71.6-1.40.4-0.3
Intermittent access intake escalation1.53.15.7-2.4-2.4-2.4-2.1-1.7-2.0-1.8-1.5-1.71.61.5-1.30.0-0.0
Intermittent access intake escalation 24.65.28.6-2.9-2.8-2.7-2.7-2.5-2.4-2.4-2.2-2.32.22.1-2.00.6-0.6
Intermitt. access day 1 inactive lever presses1.03.95.61.41.31.42.02.42.22.12.32.0-2.2-2.02.2-1.81.8
Intermitt. access day 15 inactive lever presses1.32.64.50.10.60.71.51.61.91.61.61.7-1.7-1.81.9-2.12.1
Intermitt. access escalation Index1.72.43.40.80.90.81.61.71.81.61.51.7-1.7-1.81.8-1.71.7
Intermittent access day 1 total infusions2.74.36.7-2.1-1.7-1.6-2.1-2.6-2.2-2.2-2.6-2.02.32.1-2.11.6-1.5
Intermittent access day 15 total infusions5.68.412.1-3.5-3.2-3.2-3.3-3.2-3.2-3.1-3.0-3.02.92.8-2.61.1-1.1
Intermittent access terminal intake (last 3 days)6.88.914.6-3.8-3.2-3.0-3.3-3.6-3.2-3.1-3.3-2.93.02.8-2.71.2-1.2
Intermittent access total infusions5.16.08.5-2.9-2.6-2.4-2.7-2.9-2.7-2.6-2.7-2.52.52.4-2.31.2-1.1
Intermittent access day 1 locomotion0.81.12.2-1.4-0.9-0.7-0.9-1.5-0.9-1.1-1.4-0.91.11.0-1.00.7-0.7
Intermittent access day 15 total locomotion1.01.83.7-1.4-1.1-0.8-1.3-1.9-1.5-1.4-1.6-1.21.51.4-1.31.1-1.1
Intermittent access total locomotion2.02.44.7-2.0-1.5-1.3-1.6-2.2-1.7-1.6-1.9-1.41.61.5-1.40.9-0.8
Intermittent access standard deviation1.73.67.5-2.7-2.7-2.7-2.3-1.8-1.8-1.9-1.5-2.01.71.6-1.3-0.20.2
Left kidney weight0.10.31.0-0.6-0.2-0.50.30.30.70.30.40.3-0.4-0.70.5-1.01.0
Right kidney weight0.10.61.20.30.70.51.00.51.10.80.60.8-0.8-1.10.8-0.70.6
Cocaine induced anxiety0.60.81.10.60.70.70.91.01.01.00.91.1-1.0-1.11.0-0.80.8
Post-drug Anxiety1.41.53.31.81.41.41.31.41.11.31.51.2-1.2-1.01.0-0.30.3
Baseline Anxiety0.20.20.60.80.50.40.0-0.0-0.4-0.10.0-0.20.20.4-0.20.8-0.8
Tail length0.21.03.21.31.81.41.20.90.60.90.90.7-0.7-0.90.50.3-0.4
Length with tail0.10.62.61.51.61.00.70.20.10.30.40.2-0.2-0.5-0.01.0-1.0
Length without tail0.20.71.40.1-0.2-0.6-0.8-0.9-0.9-1.0-0.8-0.90.90.8-1.01.2-1.2
Times rat made contact with spout0.00.00.1-0.4-0.2-0.2-0.2-0.1-0.1-0.2-0.3-0.10.20.2-0.20.0-0.0
Lifetime Intake3.34.07.1-2.7-2.4-2.2-2.3-2.3-2.1-2.1-2.1-2.02.01.9-1.70.5-0.5
Liver weight, left0.10.20.80.70.90.90.50.20.10.30.10.3-0.1-0.20.00.6-0.7
Liver weight, right0.61.12.00.40.50.30.90.91.21.01.01.2-1.1-1.41.3-1.31.3
Locomotor activity0.00.00.00.20.00.00.0-0.10.0-0.0-0.10.00.0-0.1-0.00.1-0.1
Locomotor testing distance0.00.00.10.30.20.20.0-0.0-0.1-0.1-0.2-0.00.1-0.0-0.10.3-0.3
Locomotor testing rearing0.40.71.7-1.3-0.9-1.0-0.9-0.6-0.9-0.9-1.2-0.80.90.5-0.60.2-0.1
Locomotion in novel chamber0.30.41.61.00.91.30.50.10.10.30.20.4-0.10.10.10.8-0.8
Locomotion in novel chamber post-restriction0.10.20.40.10.1-0.00.30.40.40.40.50.3-0.5-0.50.6-0.60.6
Fecal boli incidents, locomotor time 10.10.10.40.20.60.60.50.20.40.40.10.4-0.3-0.40.2-0.00.0
Change in fecal boli incidents, locomotor task2.12.03.9-1.6-1.8-2.0-1.7-1.4-1.4-1.6-1.5-1.51.41.4-1.00.4-0.4
Time >=10cm from walls, locomotor time 11.61.72.3-1.4-1.2-0.9-1.4-1.5-1.4-1.4-1.4-1.41.41.5-1.31.0-1.0
Bouts of movement, locomotor time 11.82.06.0-0.2-0.3-0.40.61.51.31.21.61.0-1.4-1.41.7-2.42.5
Total resting periods, locomotor time 11.01.23.7-0.3-0.4-0.60.31.10.90.81.20.6-1.0-1.01.3-1.91.9
Rest time, locomotor task time 10.20.30.9-0.0-0.4-0.6-0.00.30.40.30.60.2-0.4-0.40.7-1.01.0
Distance moved, locomotor task time 10.00.00.10.30.30.40.10.20.00.10.10.1-0.00.0-0.20.2-0.2
Vertical activity count, locomotor time 10.30.61.90.30.10.3-0.4-0.6-0.9-0.6-0.6-0.60.80.9-1.11.4-1.4
Time >=10cm from walls, locomotor time 21.01.52.2-1.0-0.6-0.5-1.1-1.3-1.3-1.3-1.4-1.21.41.5-1.31.4-1.4
Bouts of movement, locomotor time 21.82.85.30.50.50.31.31.91.91.71.81.5-1.8-1.82.0-2.32.3
Total resting periods, locomotor time 21.73.05.80.50.50.31.42.01.91.71.91.6-1.9-1.92.1-2.42.4
Rest time, locomotor task time 20.60.71.20.50.30.20.71.00.80.80.90.8-0.9-1.01.1-1.11.1
Distance moved, locomotor task time 20.00.00.1-0.10.10.10.00.20.20.10.20.1-0.1-0.10.2-0.20.2
Vertical activity count, locomotor time 20.40.51.61.11.21.30.70.50.40.50.30.5-0.3-0.30.20.7-0.7
Light reinforcement 11.12.74.11.11.41.31.81.41.81.91.61.9-1.8-2.01.9-1.51.5
Light reinforcement 22.03.14.31.91.92.02.11.41.82.01.82.1-1.9-1.91.7-0.90.8
Bone: marrow area1.43.04.9-0.8-0.6-0.6-1.5-2.1-1.8-1.7-1.9-1.71.91.9-2.12.2-2.2
Bone: maximum diameter0.10.20.8-0.5-0.00.1-0.4-0.9-0.5-0.3-0.6-0.10.40.1-0.40.4-0.4
Bone: maximum force0.51.03.00.00.50.7-0.4-1.4-0.9-0.7-1.0-0.50.90.6-1.01.7-1.7
Bone: maximum moment0.81.43.2-0.30.10.2-0.8-1.6-1.2-1.0-1.3-0.91.21.0-1.31.8-1.8
Mean time between licks in bursts0.20.51.81.00.80.80.2-0.1-0.1-0.1-0.1-0.10.30.4-0.51.3-1.3
Mean num. licks in bursts0.20.30.50.30.60.40.70.60.70.60.50.6-0.6-0.60.6-0.50.5
Cd content in liver1.01.21.60.50.60.71.00.91.11.21.21.3-1.3-1.21.2-1.21.2
Co content in liver1.31.53.30.30.10.10.81.51.21.21.41.1-1.3-1.11.4-1.81.8
Cu content in liver1.51.84.3-2.1-2.0-2.0-1.5-1.1-1.1-1.2-1.2-1.31.01.0-0.9-0.40.4
Fe content in liver0.91.11.5-0.8-0.8-0.8-1.1-1.0-1.2-1.2-1.2-1.21.21.2-1.11.0-1.0
K content in liver0.20.21.0-0.7-0.8-1.0-0.50.2-0.2-0.3-0.1-0.50.10.1-0.1-0.60.6
Mg content in liver0.30.30.9-0.6-0.8-0.9-0.6-0.1-0.5-0.5-0.3-0.70.40.4-0.4-0.10.1
Mn content in liver0.10.10.50.30.2-0.10.30.70.50.30.40.1-0.4-0.40.3-0.40.4
Na content in liver0.50.61.6-1.3-1.0-1.3-0.8-0.6-0.5-0.7-0.7-0.90.60.2-0.5-0.30.3
Rb content in liver0.10.10.6-0.1-0.2-0.1-0.10.80.10.30.30.2-0.3-0.40.5-0.60.6
Se content in liver0.20.20.6-0.1-0.0-0.20.40.70.50.40.50.2-0.5-0.50.5-0.80.8
Sr content in liver0.20.10.40.60.2-0.10.2-0.2-0.1-0.3-0.1-0.50.30.4-0.50.6-0.6
Zn content in liver1.41.53.8-1.8-1.9-2.0-1.4-1.1-0.9-1.1-0.9-1.20.91.0-0.9-0.50.5
Bone: minimum diameter1.62.910.00.40.81.0-0.6-1.8-1.5-1.2-1.7-1.01.61.5-1.93.2-3.2
Time in familiar zone, hab. session 10.40.41.5-0.5-0.8-0.9-0.20.60.50.10.50.0-0.4-0.20.5-1.21.2
Time in novel zone, hab. session 10.10.10.2-0.20.30.40.1-0.5-0.5-0.1-0.4-0.00.20.0-0.20.5-0.5
Total zone transitions, hab. session 10.40.62.21.51.21.20.90.30.60.60.60.6-0.5-0.40.30.6-0.6
Total locomotion distance, hab. session 10.30.51.90.80.60.60.0-0.6-0.4-0.3-0.4-0.20.50.5-0.61.3-1.4
Locomotion velocity, hab. session 10.40.51.91.11.01.00.3-0.3-0.2-0.1-0.10.10.20.2-0.41.3-1.4
Time in familiar zone, hab. session 20.80.93.0-1.1-1.4-1.4-0.60.60.40.00.4-0.0-0.3-0.10.5-1.71.7
Time in novel zone, hab. session 20.70.72.30.30.80.70.1-1.0-0.7-0.4-0.7-0.30.60.4-0.71.5-1.5
Total zone transitions, hab. session 20.60.81.31.00.70.60.91.11.00.91.00.9-1.0-0.91.0-0.70.7
Total locomotion distance, hab. session 20.10.10.30.50.50.60.30.20.10.20.00.2-0.1-0.10.00.4-0.4
Locomotion velocity, hab. session 20.00.10.20.40.40.50.20.20.10.10.00.2-0.1-0.10.00.3-0.3
Novel to familiar place preference ratio0.10.10.4-0.10.20.1-0.1-0.4-0.4-0.3-0.3-0.30.40.3-0.40.6-0.6
Novelty place preference0.10.10.2-0.30.1-0.0-0.1-0.4-0.4-0.2-0.3-0.30.30.2-0.30.4-0.4
Time in novel zone, NPP test0.00.00.1-0.30.20.10.1-0.1-0.20.0-0.0-0.10.1-0.1-0.10.1-0.1
Total zone transitions, NPP test0.91.32.31.51.11.01.21.41.41.21.31.2-1.2-1.01.1-0.50.5
Total locomotion distance, NPP test0.20.20.80.90.80.80.40.00.10.20.10.3-0.1-0.1-0.00.7-0.7
Locomotion velocity, NPP test0.20.21.00.60.50.5-0.0-0.4-0.3-0.2-0.3-0.10.30.3-0.41.0-1.0
Intraocular pressure0.81.23.81.91.61.81.20.70.70.80.70.8-0.7-0.60.50.8-0.8
Delta distance traveled before/after self-admin3.23.35.1-2.2-1.8-1.9-1.9-2.0-2.0-1.9-2.0-2.01.91.8-1.80.9-0.9
Delta ambulatory time before/after self-admin2.73.35.4-2.3-1.9-1.8-1.9-2.0-2.0-1.9-2.0-1.91.91.8-1.80.9-0.8
Parametrial fat weight0.00.10.30.50.20.20.0-0.0-0.1-0.1-0.1-0.00.10.3-0.10.6-0.6
Pavlov. Cond. lever latency0.20.20.8-0.9-0.8-0.8-0.5-0.1-0.2-0.2-0.1-0.20.10.1-0.1-0.60.6
Pavlov. Cond. magazine entry latency0.10.20.50.70.60.60.20.00.10.10.00.10.00.1-0.10.7-0.7
Pavlov. Cond. change in total contacts1.11.23.11.71.71.81.20.60.80.90.71.0-0.7-0.70.50.7-0.7
Pavlov. Cond. index score0.40.51.21.11.01.00.80.50.60.60.50.7-0.5-0.50.50.3-0.3
Pavlov. Cond. latency score0.40.51.11.11.01.00.80.60.60.60.60.7-0.5-0.50.50.2-0.2
Pavlov. Cond. lever contacts0.30.31.11.00.90.80.4-0.1-0.00.0-0.10.00.10.1-0.21.1-1.1
Pavlov. Cond. magazine entry number0.50.61.3-1.2-1.1-1.1-0.9-0.6-0.8-0.8-0.7-0.80.70.7-0.6-0.10.1
Pavlov. Cond. intertrial magazine entries0.60.70.9-0.8-0.8-0.8-0.9-0.8-0.9-1.0-0.9-0.90.90.9-0.90.6-0.6
Pavlov. Cond. lever-magazine prob. diff.0.30.41.01.01.01.00.70.40.50.50.40.6-0.4-0.40.40.3-0.3
Pavlov. Cond. response bias0.30.41.21.11.01.00.60.10.30.30.10.3-0.1-0.10.00.8-0.8
Pavlov. Cond. lever latency1.11.62.11.21.41.11.51.41.31.41.31.4-1.3-1.31.3-0.60.6
Pavlov. Cond. magazine entry latency0.00.00.1-0.10.00.2-0.3-0.1-0.2-0.1-0.2-0.10.20.1-0.20.2-0.2
Pavlov. Cond. change in total contacts1.21.94.3-0.2-0.2-0.1-1.0-1.4-1.4-1.3-1.5-1.31.51.5-1.62.1-2.1
Pavlov. Cond. index score0.81.01.8-0.4-0.4-0.2-1.0-1.1-1.1-1.1-1.1-1.01.11.1-1.21.3-1.3
Pavlov. Cond. latency score0.81.11.5-0.6-0.6-0.4-1.1-1.2-1.1-1.1-1.1-1.11.21.2-1.21.1-1.1
Pavlov. Cond. lever contacts0.81.11.6-0.9-1.1-0.8-1.3-1.1-1.1-1.2-1.1-1.21.21.2-1.20.7-0.7
Pavlov. Cond. magazine entry number0.10.10.3-0.1-0.1-0.30.20.20.30.20.30.2-0.3-0.30.3-0.60.6
Pavlov. Cond. intertrial magazine entries0.10.10.40.60.50.50.3-0.1-0.10.00.00.00.10.1-0.20.7-0.7
Pavlov. Cond. lever-magazine prob. diff.0.71.01.5-0.4-0.5-0.3-1.0-1.1-1.0-1.1-1.1-1.01.11.1-1.21.2-1.2
Pavlov. Cond. response bias0.81.11.5-0.5-0.6-0.4-1.0-1.1-1.2-1.1-1.2-1.11.21.1-1.21.2-1.2
Time in closed arm before self-admin0.30.41.4-1.2-1.0-1.0-0.60.1-0.5-0.5-0.4-0.50.30.2-0.2-0.50.5
Time in closed arm after self-admin0.60.72.3-0.4-0.6-0.6-0.01.10.40.51.00.3-0.7-0.60.9-1.51.5
Time in open arm before self-admin0.40.51.20.00.10.0-0.4-1.1-0.6-0.6-0.7-0.50.70.7-0.81.1-1.1
Time in open arm after self-admin0.20.20.70.70.80.60.60.10.30.3-0.10.4-0.2-0.20.00.5-0.5
Bone: periosteal estimation1.32.77.0-0.20.20.3-1.0-2.1-1.6-1.4-1.8-1.21.71.5-1.92.6-2.6
Bone: periosteal perimeter0.50.92.5-0.7-0.3-0.2-0.8-1.6-0.9-0.9-1.1-0.71.00.8-1.11.1-1.1
Bone: post-yield work2.63.86.3-2.5-2.2-2.2-2.2-2.4-1.9-2.0-2.1-2.01.91.8-1.80.6-0.6
Progressive ratio test 1 active lever presses1.01.23.4-1.8-1.5-1.3-1.2-1.3-1.1-1.0-1.1-1.01.00.9-0.8-0.10.1
Progressive ratio test 1 breakpoint1.11.43.5-1.9-1.5-1.3-1.3-1.4-1.2-1.1-1.2-1.01.10.9-0.90.00.0
Progressive ratio test 1 inactive lever presses0.00.00.1-0.3-0.10.1-0.10.2-0.2-0.0-0.1-0.10.10.30.00.1-0.1
Progressive ratio test 2 active lever presses5.66.69.0-2.4-2.6-2.4-2.9-2.8-3.0-2.8-2.6-2.72.72.9-2.51.6-1.5
Progressive ratio test 2 breakpoint5.56.38.7-2.3-2.6-2.3-2.8-2.7-2.9-2.7-2.6-2.62.62.8-2.51.6-1.5
Progressive ratio test 2 inactive lever presses0.81.32.2-1.5-1.3-1.1-1.3-1.3-1.3-1.2-1.2-1.11.21.2-1.10.5-0.4
Incentive Sensitization - Responses4.56.49.1-1.5-1.9-1.7-2.6-2.8-3.0-2.7-2.7-2.62.73.0-2.72.4-2.4
Incentive Sensitization - Breakpoint4.86.28.9-1.5-2.0-1.8-2.6-2.8-3.0-2.7-2.6-2.62.73.0-2.72.3-2.3
Sum of active levers in priming session hrs 5-61.71.62.2-0.5-1.0-0.7-1.3-1.2-1.5-1.4-1.3-1.31.41.5-1.51.3-1.3
Progressive ratio0.40.62.2-1.1-0.9-1.1-0.10.00.40.10.20.2-0.3-0.60.7-1.51.5
Food seeking constrained by brief footshock1.31.55.42.32.02.21.20.60.60.91.00.9-0.6-0.40.21.1-1.1
Seeking ratio, punishment vs. effort1.01.45.22.31.82.10.80.50.10.50.60.4-0.20.1-0.31.6-1.6
Retroperitoneal fat weight0.10.51.21.11.00.80.60.80.40.71.00.6-0.6-0.60.6-0.10.1
Reaction time number correct0.91.72.4-0.7-0.7-0.6-1.3-1.2-1.5-1.3-1.3-1.41.51.5-1.41.5-1.5
Reaction time mean minus median1.84.46.51.81.82.32.42.12.42.21.92.6-2.2-2.32.3-1.41.4
Reaction time mean minus median AUC1.84.57.22.02.12.72.52.12.32.21.82.6-2.1-2.22.2-1.01.0
Reaction time num false alarms2.63.65.0-1.4-1.2-1.0-1.9-2.2-1.9-2.0-2.1-1.92.12.1-2.22.0-2.0
Reaction time num false alarms AUC2.23.54.8-1.5-1.3-1.0-1.9-2.2-1.9-2.0-2.1-1.92.12.0-2.11.9-1.8
Reaction time trials correct on left0.91.72.4-0.7-0.7-0.6-1.3-1.2-1.5-1.3-1.3-1.41.51.5-1.41.5-1.5
Reaction time trials on left0.81.52.4-0.6-0.6-0.5-1.2-1.2-1.4-1.3-1.2-1.31.41.5-1.41.5-1.5
Reaction time mean1.21.95.01.71.52.21.61.21.31.41.11.7-1.3-1.31.3-0.20.2
Reaction time mean AUC1.21.95.41.61.62.31.61.01.21.41.01.7-1.2-1.21.2-0.00.0
Median of all reaction times0.70.93.61.41.21.91.00.60.60.80.61.1-0.7-0.60.70.5-0.5
Reaction time omissions3.65.28.02.52.82.82.81.82.42.42.02.7-2.2-2.62.2-0.70.7
Reaction time false alarm rate0.30.40.7-0.7-0.6-0.4-0.6-0.8-0.5-0.6-0.7-0.50.60.6-0.70.3-0.3
Reaction time premature initiation rate0.60.82.3-1.4-1.5-1.5-0.8-0.8-0.4-0.6-0.5-0.80.40.4-0.4-0.90.9
Reaction time premature initiations0.71.32.7-1.5-1.6-1.6-1.2-1.2-1.0-1.1-1.0-1.31.01.0-0.9-0.10.1
Std. dev. reaction times1.52.84.51.41.42.11.91.51.81.81.42.1-1.8-1.81.9-1.11.1
Reaction time trials completed0.81.52.4-0.6-0.6-0.5-1.2-1.2-1.4-1.3-1.2-1.31.41.5-1.41.5-1.5
Reaction time trials AUC0.71.42.5-0.5-0.5-0.3-1.1-1.1-1.4-1.2-1.2-1.31.31.4-1.31.6-1.6
Run reversals in cocaine runway, females0.20.20.80.90.60.60.50.10.30.50.40.5-0.5-0.50.4-0.10.1
Run reversals in cocaine runway, males1.21.23.11.81.71.81.30.70.90.90.51.0-0.7-0.90.60.5-0.5
Latency to leave start box in cocaine runway0.60.61.2-1.1-1.0-1.0-0.8-0.8-0.7-0.9-0.8-0.80.80.8-0.60.2-0.2
Latency to leave start box in cocaine runway, F2.32.64.4-2.0-2.0-2.1-1.8-1.6-1.5-1.8-1.6-1.71.61.7-1.30.5-0.4
Latency to leave start box in cocaine runway, M1.91.72.91.51.61.71.61.21.41.41.31.4-1.3-1.41.2-0.40.3
Std. dev. time between licks in bursts0.20.30.70.2-0.10.1-0.3-0.5-0.5-0.5-0.4-0.50.50.6-0.60.8-0.9
Total sessions with >9 infusions0.81.03.3-1.8-1.6-1.4-1.1-0.8-0.8-0.8-0.9-0.80.70.7-0.5-0.50.5
Short access day 1 total inactive lever presses0.50.61.8-1.3-1.3-1.2-0.50.20.0-0.10.2-0.2-0.1-0.10.4-1.31.4
Short access day 10 total inactive lever presses0.51.32.80.80.20.20.81.71.41.11.70.8-1.2-0.91.3-1.41.4
Short access day 1 total infusions0.81.13.4-1.6-1.8-1.6-1.3-0.8-0.8-0.9-0.6-0.90.70.7-0.4-0.70.7
Short access day 10 total infusions1.72.24.7-2.2-1.8-1.7-1.6-1.7-1.4-1.5-1.7-1.41.41.3-1.20.3-0.3
Short access total infusions1.11.33.6-1.9-1.6-1.4-1.3-1.2-1.1-1.1-1.2-1.11.00.9-0.8-0.10.1
Short access day 1 locomotion0.10.10.6-0.8-0.5-0.2-0.20.20.10.1-0.10.1-0.1-0.10.3-0.70.7
Short access day 10 total locomotion0.30.60.90.40.60.70.90.61.00.90.70.9-0.8-0.80.9-0.60.6
Short access total locomotion0.20.31.3-1.1-0.7-0.5-0.5-0.6-0.3-0.4-0.6-0.40.40.4-0.3-0.10.1
One hour access (0.3 mA shock)6.37.29.5-2.6-2.7-2.6-3.0-3.0-3.1-2.9-2.8-2.92.92.9-2.61.7-1.7
Compulsive drug intake0.80.92.31.20.90.61.01.51.01.01.30.7-1.0-0.80.8-0.70.7
One hour access (shock baseline)7.511.415.6-3.5-3.3-3.0-3.7-4.0-3.9-3.6-3.7-3.53.63.4-3.32.1-2.1
Social response proportion0.50.61.00.40.60.60.90.91.00.80.70.8-0.8-1.00.9-0.70.7
Social responses1.21.62.40.81.01.01.31.51.31.31.21.4-1.3-1.51.5-1.11.1
Social time0.10.10.4-0.50.20.50.1-0.4-0.3-0.1-0.60.00.2-0.0-0.20.4-0.4
Soleus weight0.61.73.61.61.91.91.51.01.01.31.11.4-1.1-1.41.00.0-0.0
Bone: stiffness0.10.20.70.20.60.70.1-0.7-0.1-0.1-0.50.10.3-0.1-0.30.8-0.8
Tibialis anterior weight4.615.733.35.85.85.64.83.33.63.93.63.9-3.4-3.42.80.5-0.6
Time to tail flick, vehicle, before self-admin0.80.81.8-0.3-0.8-0.7-1.1-0.7-1.3-1.0-0.6-1.11.01.1-1.00.8-0.8
Time to tail flick, vehicle, after self-admin2.02.74.3-1.7-2.1-2.1-2.0-1.6-1.8-1.7-1.2-1.81.51.8-1.50.5-0.4
Time to tail flick, test, before self-admin0.40.51.10.00.2-0.20.40.90.60.60.70.5-0.7-0.90.7-1.01.0
Time to tail flick, test, after self-admin0.70.73.0-1.7-1.0-1.3-0.9-0.7-0.7-0.7-0.8-0.70.70.4-0.3-0.30.3
Delta time to tail flick, vehicle, before/after SA1.91.83.3-1.8-1.8-1.7-1.5-1.4-1.1-1.4-1.3-1.41.31.4-1.10.2-0.2
Delta time to tail flick, test, before/after SA0.00.00.1-0.3-0.10.20.20.00.30.20.00.3-0.2-0.10.3-0.30.3
Tibia length0.61.63.5-1.8-1.8-1.9-1.7-0.9-1.2-1.2-0.8-1.41.11.0-0.9-0.30.3
Ambulatory time before self-admin0.81.12.41.51.11.11.11.11.41.01.01.1-1.0-1.01.1-0.30.3
Ambulatory time after self-admin0.50.61.1-0.7-0.6-0.6-0.7-0.9-0.6-0.9-1.0-0.80.80.7-0.80.7-0.7
Bone: tissue strength1.81.85.0-2.2-1.8-1.9-1.4-1.2-1.1-1.3-1.4-1.41.21.2-1.0-0.10.1
Total heroin consumption0.70.81.5-0.4-0.1-0.1-0.7-1.0-1.0-0.9-1.0-0.91.01.0-1.11.2-1.2
Bone: trabecular number0.61.02.1-0.9-1.0-1.0-1.2-1.4-1.1-1.1-1.1-1.01.10.8-1.10.7-0.7
Bone: trabecular spacing1.62.23.61.21.21.21.51.91.61.61.61.5-1.6-1.41.6-1.21.2
Bone: trabecular thickness3.24.06.6-1.5-1.5-1.2-2.1-2.6-2.3-2.1-2.3-1.92.22.0-2.21.9-1.9
Bone: trabecular tissue density2.84.25.71.82.22.22.32.02.12.21.92.4-2.1-2.42.2-1.21.2
Water consumed over 24 hours0.10.10.20.30.30.50.30.20.30.30.10.4-0.2-0.30.20.0-0.0
Number of responses in last shaping day0.30.30.9-0.9-0.8-0.7-0.6-0.6-0.5-0.6-0.7-0.50.50.4-0.3-0.10.1