Hub : Genes

Impa1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL alternative TSS XM_006232151.4 0.26 0.16 1.9e-03 0.09 0.05 0.04 0.06 3.6e-03 3.0e-02 3.1e-02 1.7e-02
2 LHb mRNA stability Impa1 0.41 0.17 4.4e-05 0.06 0.01 0 0.02 1.9e-02 2.0e-01 2.8e-01 9.0e-02
3 Brain mRNA stability Impa1 0.31 0.13 0.0e+00 0.09 0.11 0.11 0.11 1.3e-08 1.4e-10 3.2e-10 3.6e-10
4 IL alternative TSS NM_032057.2 0.29 0.18 1.1e-03 0.05 0.06 0.07 0.06 2.4e-02 1.7e-02 1.1e-02 1.2e-02
5 NAcc mRNA stability Impa1 0.15 0.1 2.4e-10 0.06 0.06 0.07 0.07 2.2e-07 4.9e-08 3.7e-08 8.6e-09
6 pVTA mRNA stability Impa1 0.08 0.06 4.3e-03 0.06 0.01 0.02 0.03 1.8e-03 9.4e-02 4.2e-02 2.3e-02
7 Eye isoform ratio XM_006232151.4 0.39 0.19 2.8e-03 0.06 0.04 0 0.06 3.8e-02 8.4e-02 2.7e-01 4.1e-02
8 Adipose mRNA stability Impa1 0.36 0.23 0.0e+00 0.14 0.14 0.14 0.14 2.2e-15 1.1e-15 8.2e-16 1.8e-15
9 IL mRNA stability Impa1 0.56 0.3 9.6e-04 0.08 0.01 0.01 0.01 5.9e-03 1.4e-01 1.9e-01 1.4e-01
10 Liver mRNA stability Impa1 0.09 0.06 1.8e-07 0.05 0.05 0.05 0.05 2.4e-06 3.1e-06 4.0e-06 3.0e-06
11 Eye isoform ratio NM_032057.2 0.36 0.19 5.6e-03 0.04 0.03 0.01 0.02 8.9e-02 1.0e-01 2.1e-01 1.6e-01
12 Liver intron excision ratio chr2_91470269_91471317 0.04 0.03 1.4e-03 0 0.02 -0 0.01 2.0e-01 5.9e-03 5.5e-01 4.4e-02
13 Liver intron excision ratio chr2_91471425_91472941 0.05 0.04 4.9e-04 0 0.02 0.01 0.01 1.5e-01 2.2e-03 8.2e-03 1.6e-02
14 PL mRNA stability Impa1 0.55 0.18 2.2e-12 0.06 0.07 0.09 0.08 1.0e-07 1.8e-08 3.7e-10 4.4e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.62.63.9-1.41.6-1.90.8-1.92.0-2.01.81.41.81.81.4-1.30.9
Area under the delay curve1.21.22.11.0-1.11.3-0.61.3-0.91.4-1.3-1.1-1.4-1.2-0.80.8-0.8
BMI with tail0.93.09.32.5-2.52.1-3.01.4-1.41.3-1.7-1.1-1.4-1.30.8-0.8-1.0
BMI without tail2.96.011.73.2-3.43.0-3.32.5-2.32.3-2.6-2.4-2.3-2.20.0-0.1-1.8
Body weight0.31.25.71.6-1.91.2-2.40.6-0.60.6-0.6-0.5-0.3-0.21.1-1.1-0.3
Weight adjusted by age0.10.20.60.4-0.70.2-0.80.2-0.0-0.1-0.40.2-0.6-0.40.3-0.30.3
Bone surface4.27.311.6-2.12.0-2.80.3-3.03.2-3.42.93.03.13.12.8-2.81.8
Bone volume3.96.610.2-1.91.9-2.70.4-2.93.1-3.22.72.82.82.82.7-2.71.8
Breakpoint value in progressive ratio session0.70.81.61.2-1.21.2-1.31.0-0.70.7-1.0-0.7-0.8-0.80.1-0.1-0.5
Number of licking bursts0.50.61.0-1.00.7-0.90.5-0.81.0-0.50.80.90.80.80.6-0.60.6
Context. condit. distance diff. score0.30.30.80.5-0.10.40.20.6-0.70.9-0.3-0.7-0.2-0.2-0.80.8-0.7
Locomotion velocity, session 11.71.93.01.5-1.71.7-1.71.4-1.51.4-1.5-1.1-1.3-1.3-0.30.3-1.3
Locomotion distance, session 10.60.73.31.4-1.30.9-1.80.4-0.60.3-0.5-0.4-0.4-0.40.8-0.8-0.0
Locomotion velocity, session 21.41.62.81.7-1.71.5-1.51.3-1.31.1-1.4-0.9-1.4-1.4-0.10.0-0.9
Locomotion distance, session 20.60.93.61.4-1.40.8-1.90.2-0.2-0.1-0.5-0.1-0.3-0.31.3-1.40.4
Locomotion velocity, session 30.10.10.7-0.2-0.00.1-0.10.2-0.30.3-0.2-0.2-0.2-0.2-0.30.3-0.9
Locomotion distance, session 30.40.40.6-0.60.4-0.7-0.2-0.80.7-0.70.70.80.70.70.8-0.8-0.0
Stereotopy head waving bouts, day 30.30.31.30.3-0.4-0.1-0.6-0.40.5-0.30.30.40.50.51.1-1.10.6
Stereotopy head waving duration, day 30.20.30.70.8-0.80.6-0.60.5-0.50.5-0.5-0.5-0.3-0.40.2-0.2-0.0
Locomotion velocity, session 77.48.111.4-1.92.2-2.90.2-3.33.2-3.23.23.23.33.43.0-2.92.2
Locomotion distance, session 74.05.17.0-2.12.4-2.61.2-2.62.4-2.52.62.32.62.61.5-1.41.8
Stereotopy head waving bouts, day 70.20.20.80.5-0.90.5-0.90.3-0.1-0.0-0.40.0-0.2-0.20.6-0.6-0.2
Stereotopy head waving duration, day 70.80.91.60.9-1.31.2-0.81.2-1.00.9-1.2-0.8-1.1-1.1-0.40.4-0.9
Locomotion velocity, session 83.13.75.52.2-2.42.3-1.42.2-2.12.3-2.1-2.0-1.9-1.9-0.80.8-1.7
Locomotion distance, session 80.60.92.21.5-1.41.2-1.31.0-1.01.1-0.9-0.8-0.6-0.60.1-0.1-0.4
Degree of sensitization distance0.40.41.0-0.30.7-0.70.5-0.60.6-0.90.70.40.70.70.3-0.31.0
Degree of sensitization stereotypy1.01.12.10.9-1.51.4-1.01.3-1.10.7-1.3-0.7-1.2-1.1-0.20.2-0.9
Conditioned locomotion0.10.10.30.4-0.50.4-0.40.4-0.40.2-0.4-0.4-0.4-0.4-0.00.00.3
Cocaine response after cond. corrected0.50.61.7-1.31.0-0.90.9-0.70.6-0.70.80.70.80.8-0.10.10.4
Cocaine response after cond. not corrected1.11.23.4-1.81.3-1.31.3-1.01.0-1.01.11.21.01.00.1-0.10.9
Cocaine response before conditioning0.40.51.2-0.90.4-0.70.5-0.81.0-0.60.61.10.50.60.7-0.70.9
Saline control response2.22.94.0-1.11.1-1.6-0.1-1.92.0-1.81.81.91.92.02.0-1.91.6
Bone: connectivity density1.62.53.7-1.51.8-1.90.9-1.81.8-1.91.91.41.81.91.0-1.00.8
Bone: cortical apparent density1.21.62.71.5-0.91.3-0.51.3-1.41.5-1.2-1.6-1.3-1.2-0.90.9-1.5
Bone: cortical area0.50.82.2-0.30.1-0.6-0.6-0.91.1-1.20.60.90.80.81.5-1.50.3
Bone: cortical porosity0.20.30.8-0.10.0-0.3-0.3-0.40.7-0.60.30.60.40.50.9-0.90.2
Bone: cortical porosity0.10.20.50.1-0.2-0.1-0.5-0.30.4-0.40.10.40.20.20.7-0.70.0
Bone: cortical thickness0.20.41.50.5-0.60.1-1.0-0.30.5-0.4-0.00.10.20.21.2-1.2-0.1
Bone: cortical thickness2.02.34.41.9-2.11.7-1.31.6-1.11.0-1.9-1.6-1.7-1.7-0.00.0-1.4
Bone: cortical tissue density1.31.72.81.5-0.91.3-0.51.4-1.41.6-1.2-1.7-1.3-1.3-1.00.9-1.5
Condit. Reinf. active minus inactive responses2.22.510.22.3-2.51.5-3.20.9-0.30.3-1.10.1-0.9-0.81.9-1.9-0.9
Condit. Reinf. active-inactive response ratio3.03.313.12.7-2.81.8-3.61.1-0.60.4-1.4-0.2-1.0-1.11.8-1.9-1.2
Condit. Reinf. active responses1.82.29.32.0-2.31.2-3.00.50.0-0.1-0.80.3-0.6-0.52.1-2.2-0.5
Condit. Reinf. inactive responses0.00.00.2-0.0-0.30.0-0.2-0.10.2-0.0-0.00.00.00.10.5-0.50.3
Incentive salience index mean2.42.812.02.5-2.61.6-3.50.9-0.30.2-1.10.1-0.8-0.82.0-2.0-0.8
Condit. Reinf. lever presses1.01.35.01.9-1.81.3-2.20.8-0.60.3-0.9-0.2-0.6-0.71.0-1.1-0.5
Condit. Reinf. active minus inactive responses4.96.19.6-1.61.7-2.40.2-2.72.9-3.12.62.62.82.82.8-2.82.2
Condit. Reinf. active-inactive response ratio3.03.25.0-0.81.0-1.6-0.2-1.92.1-2.21.81.92.02.02.2-2.21.4
Condit. Reinf. active responses6.08.312.9-2.02.1-2.80.4-3.13.4-3.63.03.13.23.23.1-3.12.7
Condit. Reinf. inactive responses0.60.71.3-0.50.5-0.80.2-0.81.0-1.10.90.80.90.90.9-0.91.1
Condit. Reinf. lever presses2.73.65.9-1.31.2-1.80.5-2.12.1-2.11.91.92.12.12.1-2.12.4
Condit. Reinf. lever reinforcers received6.28.713.3-2.12.2-3.00.5-3.23.4-3.63.13.13.33.33.1-3.12.7
Conditioned reinforcement - actives3.53.55.9-1.72.4-2.21.4-2.41.5-1.72.31.72.32.21.2-1.11.3
Conditioned reinforcement - inactives0.20.21.0-0.30.6-0.40.1-0.21.0-0.40.30.50.50.40.4-0.40.7
Conditioned locomotion2.42.85.0-1.22.1-1.81.0-2.21.3-1.52.11.42.22.21.2-1.21.3
Patch foraging indifference point 0 sec0.40.62.5-1.31.1-0.81.6-0.50.5-0.70.50.50.30.3-0.70.70.3
Patch foraging indifference point AUC0.60.71.40.7-0.80.9-0.31.2-0.80.6-1.2-0.7-1.1-1.1-0.70.7-0.3
Delay disc. indifference point, 0s delay0.00.00.20.10.20.00.3-0.0-0.10.30.1-0.2-0.10.1-0.40.4-0.1
Delay disc. indifference point, 16s delay1.31.32.00.9-1.21.3-0.61.4-1.21.4-1.3-1.1-1.3-1.3-0.90.9-1.0
Delay disc. indifference point, 2s delay0.40.51.91.0-0.70.3-1.4-0.10.2-0.10.00.20.10.41.2-1.20.3
Delay disc. indifference point, 24s delay0.20.20.30.0-0.30.40.10.6-0.30.5-0.5-0.4-0.6-0.6-0.60.6-0.3
Delay disc. indifference point, 4s delay2.12.23.21.4-1.71.7-0.91.8-1.41.7-1.7-1.5-1.8-1.5-1.01.0-1.2
Delay disc. indifference point, 8s delay0.60.61.7-0.0-0.20.60.40.9-0.30.8-0.8-0.6-1.3-1.0-1.11.1-0.5
Indifference point function ln k0.20.21.10.4-0.20.40.00.3-0.71.1-0.1-0.9-0.2-0.3-0.50.5-0.2
Indifference point function log k0.20.21.10.4-0.20.40.00.3-0.71.1-0.1-0.9-0.2-0.3-0.50.5-0.2
Patch foraging total patch changes 0 sec0.30.52.3-1.00.7-0.41.50.00.1-0.2-0.00.0-0.2-0.2-1.11.1-0.0
Patch foraging total patch changes 12 sec0.30.31.4-0.80.7-0.31.20.20.2-0.4-0.10.3-0.2-0.2-0.90.90.2
Patch foraging total patch changes 18 sec0.70.92.00.6-0.91.00.01.1-0.80.8-1.4-0.9-1.3-1.4-0.90.9-0.5
Patch foraging total patch changes 24 sec0.40.51.50.10.10.30.70.4-0.80.6-0.5-0.9-0.4-0.5-1.21.2-0.5
Patch foraging total patch changes 6 sec0.30.51.2-0.3-0.20.50.60.9-0.40.2-0.9-0.3-0.9-0.9-1.11.1-0.7
Patch foraging time to switch 0 sec0.81.24.61.7-1.50.8-2.10.3-0.20.4-0.3-0.40.10.11.5-1.5-1.0
Patch foraging water rate 0 sec0.30.51.7-0.60.30.21.00.6-0.50.1-0.6-0.0-0.8-0.8-1.31.30.4
Patch foraging water rate 12 sec0.71.12.6-1.61.4-1.31.4-1.01.2-0.81.01.00.90.8-0.30.30.8
Patch foraging water rate 18 sec0.40.50.9-0.80.9-0.80.9-0.70.8-0.60.80.60.80.70.1-0.10.7
Patch foraging water rate 24 sec0.50.72.1-0.20.40.41.00.6-0.71.0-0.6-0.9-0.7-0.6-1.51.5-0.1
Patch foraging water rate 6 sec1.21.73.5-1.51.9-1.61.6-1.41.3-1.01.41.11.31.20.0-0.01.4
Seeking ratio, delayed vs. immediate footshock5.76.611.6-3.43.4-3.12.8-2.52.6-2.72.72.82.32.30.4-0.32.3
Distance traveled before self-admin0.10.10.3-0.10.5-0.10.4-0.0-0.30.30.2-0.20.40.5-0.30.30.2
Distance traveled after self-admin0.30.31.0-0.50.00.10.70.5-0.50.3-0.3-0.3-0.4-0.3-1.01.0-0.7
Extensor digitorum longus weight6.224.347.46.5-6.96.2-6.05.3-5.14.9-5.2-4.8-4.3-4.3-0.40.4-3.3
Bone: elastic displacement0.60.62.00.2-0.2-0.3-1.0-0.60.9-0.60.60.70.80.81.4-1.40.5
Bone: elastic work0.70.92.50.00.0-0.6-0.8-1.01.0-0.80.90.81.01.01.6-1.60.5
Bone: endosteal estimation1.94.16.3-1.21.0-1.7-0.7-2.22.1-2.32.12.52.32.22.5-2.51.8
Bone: endosteal perimeter0.81.62.4-1.11.1-1.30.0-1.51.4-1.61.51.51.51.41.2-1.10.8
Epididymis fat weight0.41.02.7-0.0-0.00.70.10.7-1.41.2-0.7-1.2-0.8-0.8-1.61.6-0.8
Delta time in closed arm before/after self-admin0.10.10.4-0.40.2-0.10.7-0.1-0.30.20.1-0.20.10.0-0.60.6-0.6
Delta time in open arm before/after self-admin0.00.00.1-0.20.0-0.10.10.10.2-0.1-0.10.1-0.2-0.2-0.10.10.1
Diff in mean of infusions in LGA sessions0.80.83.41.3-1.31.1-1.80.7-0.50.3-0.8-0.3-0.6-0.50.8-0.8-0.6
Delay discount exponential model param0.80.91.7-0.81.0-1.10.5-1.10.6-1.11.10.81.31.10.7-0.70.6
Extinction: sum of active levers before priming0.60.61.20.8-1.01.0-1.11.0-0.50.4-1.1-0.4-1.0-0.9-0.10.1-0.1
Active lever presses in extinction session 60.30.30.8-0.60.9-0.60.4-0.70.5-0.40.60.40.60.60.1-0.10.4
Bone: final force0.40.72.10.0-0.0-0.4-1.1-0.80.9-0.90.50.80.70.71.4-1.4-0.3
Bone: final moment0.61.02.2-0.30.4-0.8-0.7-1.11.2-1.10.90.91.11.01.5-1.50.0
Food consumed during 24 hour testing period1.11.33.01.5-1.61.3-1.71.2-0.80.9-1.2-0.9-1.0-1.00.2-0.2-1.2
Glucose0.81.32.71.7-1.61.4-1.51.2-0.80.8-1.3-0.6-1.1-1.00.1-0.1-1.1
Heart weight0.81.12.3-1.51.4-1.21.5-1.00.8-0.51.20.61.10.9-0.50.50.7
Delay discount hyperbolic model param1.11.12.0-1.11.1-1.20.7-1.30.8-1.31.31.01.41.20.7-0.70.7
Intermittent access intake day 1-15 change2.32.36.1-2.52.5-1.82.5-1.40.9-1.11.41.10.71.0-0.60.60.7
Intermittent access intake escalation1.81.74.9-2.22.0-1.72.1-1.20.8-1.11.31.10.50.9-0.40.50.7
Intermittent access intake escalation 23.23.27.6-2.82.3-2.32.2-1.81.4-2.01.92.01.11.50.2-0.21.3
Intermitt. access day 1 inactive lever presses2.83.05.51.2-0.91.60.21.8-1.72.3-1.6-2.3-1.5-1.6-2.02.0-2.0
Intermitt. access day 15 inactive lever presses1.71.94.5-0.1-0.30.90.91.4-1.11.4-1.3-1.5-1.5-1.6-2.12.1-1.4
Intermitt. access escalation Index0.20.20.60.5-0.20.4-0.00.6-0.30.5-0.4-0.5-0.8-0.5-0.50.50.2
Intermittent access day 1 total infusions2.12.46.3-1.81.4-1.60.7-1.52.5-1.91.31.91.51.31.0-1.01.4
Intermittent access day 15 total infusions5.35.911.0-3.33.0-2.92.4-2.63.0-2.72.52.62.02.20.8-0.81.9
Intermittent access terminal intake (last 3 days)4.95.412.4-3.52.7-2.82.3-2.42.9-2.72.12.71.61.70.6-0.61.8
Intermittent access total infusions3.43.77.5-2.72.3-2.31.8-2.02.6-2.21.82.21.51.50.6-0.61.6
Intermittent access day 1 locomotion0.50.61.8-1.10.7-0.70.4-0.51.4-1.10.31.00.50.40.4-0.40.7
Intermittent access day 15 total locomotion1.11.12.4-1.31.1-1.10.4-1.01.3-1.50.91.50.70.90.9-0.90.8
Intermittent access total locomotion0.80.93.0-1.71.1-1.00.9-0.81.4-1.30.61.30.30.40.2-0.20.6
Intermittent access standard deviation1.92.07.3-2.32.3-1.62.7-0.90.9-0.61.10.50.40.6-1.31.30.4
Left kidney weight0.41.24.1-2.01.3-1.32.0-0.70.8-0.70.90.50.70.7-0.90.90.3
Right kidney weight0.30.72.4-1.30.6-0.41.50.1-0.00.10.1-0.4-0.3-0.3-1.51.6-0.8
Cocaine induced anxiety0.50.61.50.3-0.50.70.10.8-0.40.8-1.0-0.8-1.2-1.1-1.01.0-0.6
Post-drug Anxiety1.92.13.61.7-1.41.6-0.81.4-1.41.9-1.4-1.9-1.3-1.3-0.80.8-1.7
Baseline Anxiety0.20.20.50.5-0.2-0.0-0.5-0.1-0.2-0.10.50.10.70.70.7-0.7-0.2
Tail length0.41.12.31.1-1.51.2-1.21.2-0.91.2-1.0-1.3-0.7-0.7-0.40.4-1.0
Length with tail0.00.10.5-0.2-0.2-0.2-0.4-0.30.3-0.20.50.20.70.60.4-0.40.2
Length without tail1.02.23.4-1.21.2-1.50.3-1.71.3-1.61.81.81.91.71.2-1.21.5
Times rat made contact with spout0.10.10.4-0.30.2-0.30.4-0.10.3-0.00.1-0.00.10.1-0.00.0-0.7
Lifetime Intake2.93.37.4-2.72.4-2.11.9-1.82.4-2.01.61.91.31.30.3-0.31.3
Liver weight, left0.71.23.01.4-1.71.3-1.71.0-0.70.5-1.2-0.4-1.1-1.10.5-0.5-0.5
Liver weight, right0.40.61.20.6-0.60.8-0.10.9-0.80.8-1.0-0.4-1.1-1.1-0.70.7-0.8
Locomotor activity0.00.00.20.30.20.00.2-0.1-0.3-0.0-0.0-0.50.0-0.1-0.00.00.1
Locomotor testing distance0.10.10.60.40.1-0.10.3-0.1-0.10.00.1-0.30.20.10.2-0.20.8
Locomotor testing rearing0.50.72.1-0.81.1-1.11.4-0.80.8-0.70.80.30.60.60.0-0.01.3
Locomotion in novel chamber0.40.51.71.3-0.90.8-1.30.5-0.40.4-0.8-0.4-0.7-0.70.5-0.50.2
Locomotion in novel chamber post-restriction0.10.10.2-0.10.10.10.20.2-0.50.3-0.3-0.3-0.4-0.4-0.50.5-0.3
Fecal boli incidents, locomotor time 10.10.10.40.2-0.60.4-0.40.4-0.00.1-0.4-0.2-0.4-0.30.1-0.1-0.3
Change in fecal boli incidents, locomotor task2.01.83.7-1.41.9-1.61.1-1.41.5-1.21.51.41.31.30.5-0.51.6
Time >=10cm from walls, locomotor time 12.02.03.1-1.51.3-1.50.6-1.51.8-1.61.51.71.41.41.2-1.21.3
Bouts of movement, locomotor time 11.92.16.3-0.30.20.71.51.2-1.31.4-1.1-1.5-1.3-1.4-2.52.5-1.2
Total resting periods, locomotor time 11.11.24.0-0.40.30.51.20.9-1.01.0-0.8-1.1-0.8-1.0-2.02.0-0.9
Rest time, locomotor task time 10.50.51.9-0.50.70.01.20.3-0.60.4-0.2-0.6-0.2-0.4-1.41.4-0.4
Distance moved, locomotor task time 10.00.00.10.1-0.1-0.2-0.2-0.30.1-0.10.20.2-0.10.10.3-0.30.2
Vertical activity count, locomotor time 10.80.82.40.2-0.1-0.5-0.8-0.90.8-0.80.90.90.90.91.5-1.50.6
Time >=10cm from walls, locomotor time 21.71.82.7-0.81.0-1.3-0.1-1.51.3-1.51.41.61.51.41.6-1.61.1
Bouts of movement, locomotor time 22.32.55.40.4-0.61.20.71.7-1.81.7-1.5-1.7-1.8-1.8-2.32.3-1.1
Total resting periods, locomotor time 22.52.75.70.4-0.61.30.71.8-1.91.7-1.6-1.8-2.0-1.9-2.42.4-1.1
Rest time, locomotor task time 20.70.81.60.4-0.40.80.11.0-0.90.9-1.0-0.9-1.3-1.2-1.11.1-0.5
Distance moved, locomotor task time 20.00.00.1-0.10.1-0.10.2-0.1-0.10.00.1-0.10.0-0.0-0.20.2-0.1
Vertical activity count, locomotor time 20.40.41.61.1-0.90.5-1.30.1-0.30.2-0.3-0.20.1-0.20.8-0.9-0.2
Light reinforcement 11.52.74.01.2-1.61.7-0.61.8-1.71.4-2.0-1.6-2.0-1.9-1.51.5-2.0
Light reinforcement 22.33.15.11.8-2.22.1-1.62.1-1.51.5-2.1-1.3-1.9-1.9-0.90.8-2.3
Bone: marrow area1.73.76.1-1.10.9-1.6-0.8-2.02.0-2.22.02.42.22.12.5-2.51.7
Bone: maximum diameter0.20.50.9-0.80.6-0.80.3-0.80.9-1.00.60.70.60.50.6-0.60.2
Bone: maximum force0.61.13.1-0.20.1-0.7-1.0-1.11.2-1.10.71.20.90.91.8-1.80.2
Bone: maximum moment0.91.63.3-0.60.5-1.1-0.6-1.41.5-1.41.21.41.31.41.8-1.80.5
Mean time between licks in bursts0.50.73.51.1-1.20.6-1.90.20.00.1-0.20.40.10.11.3-1.30.0
Mean num. licks in bursts0.40.40.80.6-0.50.6-0.10.7-0.70.5-0.7-0.9-0.7-0.7-0.70.6-0.8
Cd content in liver2.73.04.10.5-1.21.60.02.0-1.91.9-1.8-2.0-2.0-2.0-1.91.9-1.8
Co content in liver1.01.12.20.7-0.40.90.41.2-1.41.4-0.9-1.3-1.0-1.0-1.51.5-0.5
Cu content in liver2.22.76.4-2.52.2-2.02.4-1.51.6-1.61.61.71.31.3-0.20.20.8
Fe content in liver2.73.28.4-0.10.4-1.2-0.9-1.71.9-1.71.62.11.81.82.4-2.42.9
K content in liver0.30.31.1-0.80.8-0.51.1-0.30.00.20.50.20.40.4-0.60.6-0.1
Mg content in liver0.30.30.6-0.80.7-0.60.6-0.70.4-0.20.70.70.70.70.1-0.10.2
Mn content in liver0.20.30.80.9-0.60.6-0.70.7-0.50.8-0.4-0.3-0.2-0.2-0.20.2-0.4
Na content in liver0.40.41.4-1.01.2-0.81.0-0.60.4-0.50.70.40.50.5-0.40.4-0.2
Rb content in liver0.10.20.50.20.00.30.20.3-0.40.7-0.5-0.3-0.6-0.5-0.50.5-0.2
Se content in liver0.10.10.3-0.10.4-0.10.50.1-0.10.40.1-0.30.00.1-0.50.50.1
Sr content in liver0.50.51.31.2-1.00.7-1.10.6-0.60.4-0.1-0.60.10.10.1-0.1-1.0
Zn content in liver0.80.82.4-1.61.3-1.01.5-0.60.5-0.50.90.50.70.7-0.50.6-1.0
Bone: minimum diameter1.93.511.00.3-0.6-0.7-2.4-1.51.8-1.91.21.81.71.63.3-3.31.0
Time in familiar zone, hab. session 10.50.52.5-0.40.8-0.21.60.1-0.40.50.0-0.5-0.00.0-1.21.20.1
Time in novel zone, hab. session 10.10.10.6-0.1-0.30.1-0.8-0.00.3-0.3-0.10.3-0.2-0.20.4-0.4-0.3
Total zone transitions, hab. session 10.50.72.31.5-1.20.9-1.50.5-0.50.1-0.6-0.7-0.4-0.50.7-0.7-0.4
Total locomotion distance, hab. session 10.40.52.00.7-0.60.0-1.0-0.30.5-0.60.20.50.40.41.4-1.40.7
Locomotion velocity, hab. session 10.40.62.11.1-0.90.4-1.4-0.10.2-0.4-0.10.20.10.11.4-1.40.3
Time in familiar zone, hab. session 21.01.14.8-1.21.4-0.62.2-0.1-0.30.50.3-0.30.10.1-1.71.7-0.2
Time in novel zone, hab. session 20.70.72.30.6-0.80.1-1.5-0.20.6-0.80.10.60.20.21.5-1.50.3
Total zone transitions, hab. session 20.50.61.20.9-0.60.9-0.30.8-1.10.7-0.8-1.0-0.9-0.8-0.60.60.1
Total locomotion distance, hab. session 20.10.10.60.5-0.50.3-0.80.1-0.1-0.1-0.20.1-0.2-0.10.5-0.50.4
Locomotion velocity, hab. session 20.10.10.30.3-0.40.2-0.60.0-0.1-0.1-0.20.2-0.1-0.10.4-0.40.5
Novel to familiar place preference ratio0.20.20.5-0.0-0.2-0.1-0.6-0.20.4-0.40.20.60.30.20.7-0.70.5
Novelty place preference0.10.10.3-0.3-0.0-0.2-0.3-0.20.4-0.30.20.50.20.20.5-0.50.5
Time in novel zone, NPP test0.00.00.1-0.2-0.1-0.0-0.20.00.2-0.10.00.2-0.0-0.10.1-0.10.2
Total zone transitions, NPP test0.71.01.61.1-1.11.2-0.81.1-1.30.9-1.0-1.3-1.0-0.9-0.50.4-0.4
Total locomotion distance, NPP test0.20.30.90.6-0.80.4-1.00.10.0-0.1-0.30.1-0.1-0.10.8-0.80.3
Locomotion velocity, NPP test0.20.31.10.2-0.50.0-0.8-0.30.4-0.50.10.50.20.31.0-1.00.7
Intraocular pressure1.01.44.61.8-1.81.4-2.11.0-0.90.7-1.0-0.9-0.6-0.50.7-0.7-0.9
Delta distance traveled before/after self-admin0.40.41.1-1.00.4-0.80.6-0.60.9-1.00.60.90.40.30.2-0.20.2
Delta ambulatory time before/after self-admin0.70.82.2-1.50.7-1.11.0-0.81.1-1.20.81.10.50.50.1-0.10.4
Parametrial fat weight0.30.71.80.9-0.50.9-0.30.9-0.91.4-0.7-1.1-0.8-0.6-0.70.7-0.6
Pavlov. Cond. lever latency0.30.41.7-1.31.0-0.61.3-0.40.10.10.4-0.10.20.3-0.60.60.3
Pavlov. Cond. magazine entry latency0.20.31.31.1-0.70.3-1.00.10.0-0.2-0.20.3-0.1-0.00.7-0.7-0.0
Pavlov. Cond. change in total contacts1.41.55.42.2-1.81.3-2.30.9-0.60.3-1.0-0.1-0.7-0.80.8-0.8-0.8
Pavlov. Cond. index score0.50.62.61.6-1.10.9-1.20.7-0.50.2-0.7-0.2-0.6-0.60.3-0.3-0.5
Pavlov. Cond. latency score0.50.62.61.6-1.10.9-1.20.7-0.50.3-0.7-0.3-0.6-0.60.2-0.2-0.6
Pavlov. Cond. lever contacts0.50.52.11.4-1.00.4-1.50.10.1-0.3-0.20.30.10.01.0-1.1-0.0
Pavlov. Cond. magazine entry number0.50.62.4-1.51.1-0.91.2-0.70.6-0.40.80.20.70.7-0.10.10.5
Pavlov. Cond. intertrial magazine entries0.60.71.2-1.10.9-0.90.6-0.90.9-0.50.90.91.00.90.5-0.50.9
Pavlov. Cond. lever-magazine prob. diff.0.50.62.51.6-1.10.8-1.30.7-0.50.2-0.7-0.2-0.5-0.60.3-0.3-0.6
Pavlov. Cond. response bias0.40.52.01.4-1.00.6-1.40.3-0.1-0.1-0.40.3-0.2-0.20.8-0.8-0.1
Pavlov. Cond. lever latency1.11.52.21.3-1.41.5-1.11.3-1.31.5-1.3-1.0-1.4-1.4-0.60.5-1.5
Pavlov. Cond. magazine entry latency0.00.00.1-0.2-0.0-0.2-0.1-0.20.3-0.10.10.10.20.20.3-0.30.3
Pavlov. Cond. change in total contacts1.52.04.6-0.10.3-1.1-0.7-1.41.6-1.41.31.31.61.62.2-2.21.4
Pavlov. Cond. index score0.91.22.1-0.50.5-1.0-0.2-1.21.3-1.11.01.01.31.31.4-1.41.2
Pavlov. Cond. latency score0.91.11.5-0.70.6-1.00.1-1.21.2-1.11.00.91.21.21.2-1.21.2
Pavlov. Cond. lever contacts0.91.32.0-0.91.2-1.30.7-1.31.2-1.31.20.91.41.40.8-0.81.4
Pavlov. Cond. magazine entry number0.10.20.5-0.10.10.20.30.3-0.50.2-0.2-0.2-0.4-0.4-0.70.7-0.6
Pavlov. Cond. intertrial magazine entries0.20.20.80.8-0.50.3-0.9-0.0-0.10.1-0.00.40.00.00.6-0.60.1
Pavlov. Cond. lever-magazine prob. diff.0.91.11.7-0.60.6-1.00.0-1.21.3-1.11.01.01.31.31.3-1.31.2
Pavlov. Cond. response bias1.11.52.1-0.70.8-1.20.0-1.31.4-1.41.21.11.51.51.4-1.41.4
Time in closed arm before self-admin0.20.20.6-0.60.6-0.50.8-0.20.2-0.10.40.10.30.4-0.40.4-0.5
Time in closed arm after self-admin0.40.41.2-0.60.5-0.21.10.1-0.50.50.1-0.40.0-0.0-1.11.1-1.0
Time in open arm before self-admin0.80.91.9-0.20.1-0.5-0.6-0.91.0-1.10.71.11.10.91.4-1.40.8
Time in open arm after self-admin0.50.51.41.0-1.20.9-1.20.7-0.40.5-0.9-0.5-0.7-0.70.3-0.3-0.1
Bone: periosteal estimation1.83.78.1-0.80.5-1.4-1.2-2.02.1-2.31.72.32.01.92.8-2.81.4
Bone: periosteal perimeter0.81.42.5-1.10.8-1.2-0.1-1.31.4-1.61.21.41.31.21.3-1.30.5
Bone: post-yield work2.33.14.8-1.92.1-2.21.5-2.02.0-2.11.91.91.81.80.6-0.60.9
Progressive ratio test 1 active lever presses1.41.45.1-2.21.8-1.02.3-0.41.0-0.50.30.50.2-0.1-1.31.40.1
Progressive ratio test 1 breakpoint1.41.45.3-2.31.8-1.12.1-0.51.3-0.70.30.70.3-0.0-1.11.10.2
Progressive ratio test 1 inactive lever presses0.50.51.3-0.20.20.20.90.60.10.9-0.4-0.9-0.4-0.6-1.11.1-1.0
Progressive ratio test 2 active lever presses2.32.54.6-2.22.0-1.91.6-1.81.9-1.71.61.71.41.30.5-0.50.9
Progressive ratio test 2 breakpoint2.42.74.3-2.02.1-1.91.4-1.82.0-1.91.71.81.61.50.8-0.71.2
Progressive ratio test 2 inactive lever presses1.21.43.1-1.81.5-1.41.2-1.21.5-1.31.11.30.80.90.3-0.30.7
Incentive Sensitization - Responses3.33.35.4-1.31.3-1.80.3-2.12.0-2.31.92.21.91.91.9-1.91.9
Incentive Sensitization - Breakpoint3.03.04.8-1.31.3-1.80.4-2.01.9-2.21.92.11.71.81.7-1.71.8
Sum of active levers in priming session hrs 5-60.60.61.0-0.20.6-0.6-0.2-0.90.8-0.90.70.90.80.81.0-1.01.0
Progressive ratio0.50.62.0-1.40.7-0.41.30.20.4-0.2-0.00.2-0.5-0.6-1.31.30.3
Food seeking constrained by brief footshock1.21.45.01.9-1.81.3-2.20.8-1.00.6-0.9-0.6-0.6-0.61.1-1.1-0.5
Seeking ratio, punishment vs. effort1.41.86.22.5-1.71.2-2.40.4-1.20.6-0.6-0.7-0.00.11.6-1.7-0.7
Retroperitoneal fat weight0.00.10.1-0.10.4-0.10.2-0.0-0.30.20.2-0.30.20.1-0.40.40.0
Reaction time number correct1.01.42.3-0.70.9-1.10.0-1.31.5-1.21.21.11.31.41.5-1.51.2
Reaction time mean minus median3.24.26.62.2-1.82.2-0.72.4-2.02.2-2.5-2.2-2.5-2.6-1.41.4-1.7
Reaction time mean minus median AUC3.34.36.82.3-2.12.2-1.02.5-1.72.2-2.5-2.2-2.6-2.6-1.01.0-1.8
Reaction time num false alarms2.43.24.8-1.41.0-1.80.0-2.02.2-2.01.92.01.91.92.1-2.11.4
Reaction time num false alarms AUC2.12.84.1-1.51.0-1.70.3-1.92.0-2.01.81.81.71.81.9-1.91.5
Reaction time trials correct on left1.01.42.3-0.70.9-1.10.0-1.31.5-1.21.21.11.31.41.5-1.51.2
Reaction time trials on left0.91.32.2-0.60.8-1.0-0.0-1.21.5-1.11.21.01.31.31.5-1.51.2
Reaction time mean1.42.03.41.9-1.61.7-1.31.5-1.31.3-1.8-1.2-1.7-1.5-0.20.2-1.0
Reaction time mean AUC1.41.93.31.8-1.71.7-1.41.5-1.21.2-1.8-1.2-1.7-1.5-0.10.1-1.1
Median of all reaction times0.91.22.61.6-1.41.3-1.51.0-1.00.9-1.3-0.7-1.1-1.00.3-0.3-0.6
Reaction time omissions3.75.08.22.2-2.62.5-1.42.6-2.22.1-2.8-2.4-2.9-2.7-1.00.9-1.7
Reaction time false alarm rate0.20.30.7-0.80.2-0.60.3-0.60.6-0.70.60.70.40.50.4-0.40.5
Reaction time premature initiation rate0.60.92.6-1.31.4-1.11.6-0.50.5-0.90.80.60.40.3-0.80.80.8
Reaction time premature initiations1.01.42.9-1.51.7-1.41.6-1.11.2-1.31.31.00.90.9-0.10.11.3
Std. dev. reaction times2.02.85.01.6-1.51.8-0.52.0-1.61.7-2.1-1.8-2.2-2.1-1.11.1-1.4
Reaction time trials completed0.91.32.2-0.60.8-1.0-0.0-1.21.5-1.11.21.01.31.31.5-1.51.2
Reaction time trials AUC0.91.22.3-0.50.7-0.9-0.2-1.21.4-1.11.11.01.31.31.5-1.51.1
Run reversals in cocaine runway, females0.60.61.30.9-0.61.0-0.70.8-1.10.7-1.0-0.7-0.9-0.8-0.40.4-0.3
Run reversals in cocaine runway, males1.61.54.81.8-1.81.5-2.21.2-0.80.8-1.3-0.8-1.0-1.00.6-0.6-0.1
Latency to leave start box in cocaine runway0.70.81.8-0.80.8-0.90.7-0.71.2-1.00.90.91.10.80.3-0.31.3
Latency to leave start box in cocaine runway, F2.42.63.9-1.81.6-1.91.6-1.41.8-1.71.81.71.81.60.5-0.52.0
Latency to leave start box in cocaine runway, M1.21.12.31.5-1.31.4-1.41.2-0.70.9-1.3-1.0-0.9-1.2-0.10.1-0.7
Std. dev. time between licks in bursts0.30.30.80.40.1-0.3-0.7-0.50.5-0.50.60.30.70.70.9-0.90.6
Total sessions with >9 infusions0.50.62.4-1.61.1-0.61.4-0.20.7-0.4-0.10.40.0-0.2-0.90.9-0.1
Short access day 1 total inactive lever presses0.30.31.2-0.80.7-0.31.10.10.20.2-0.1-0.10.1-0.3-0.90.9-0.6
Short access day 10 total inactive lever presses1.31.43.30.7-0.10.90.61.1-1.21.8-0.7-1.7-1.2-1.0-1.61.6-1.3
Short access day 1 total infusions1.01.13.3-1.71.8-1.11.7-0.80.8-0.70.60.70.50.3-0.70.70.7
Short access day 10 total infusions1.31.54.7-2.21.7-1.41.8-0.91.4-1.20.91.10.80.6-0.40.40.6
Short access total infusions1.61.95.7-2.42.0-1.61.9-1.21.7-1.31.01.30.80.7-0.30.30.6
Short access day 1 locomotion0.30.30.8-0.70.5-0.10.90.20.00.2-0.5-0.2-0.6-0.5-0.90.9-0.6
Short access day 10 total locomotion1.31.52.60.7-1.01.3-0.51.5-1.11.2-1.6-1.2-1.6-1.5-1.01.0-1.2
Short access total locomotion0.30.31.4-1.20.6-0.40.8-0.20.7-0.4-0.10.40.10.0-0.40.4-0.2
One hour access (0.3 mA shock)4.75.48.1-2.52.9-2.71.7-2.62.5-2.42.62.42.52.41.2-1.12.2
Compulsive drug intake1.01.03.31.8-0.91.2-1.01.0-1.01.4-0.7-1.4-0.2-0.6-0.30.3-0.7
One hour access (shock baseline)5.86.812.6-3.63.2-3.12.5-2.82.9-3.02.62.92.12.30.8-0.82.2
Social response proportion0.40.51.0-0.1-0.40.60.20.9-0.81.0-0.8-0.7-0.8-0.8-0.70.7-0.5
Social responses1.11.42.40.5-0.91.20.01.4-1.11.5-1.5-1.5-1.5-1.4-1.11.1-1.0
Social time0.10.10.4-0.4-0.0-0.30.1-0.20.6-0.40.10.40.00.20.4-0.40.5
Soleus weight0.51.53.41.3-1.91.4-1.61.2-1.00.9-1.4-1.2-1.2-1.2-0.00.0-1.2
Bone: stiffness0.10.20.7-0.2-0.0-0.2-0.5-0.30.6-0.50.10.90.20.20.8-0.80.0
Tibialis anterior weight4.114.131.75.5-5.64.7-5.63.7-3.53.1-3.8-3.2-2.9-2.90.7-0.8-2.1
Time to tail flick, vehicle, before self-admin1.11.22.1-0.71.4-1.10.7-1.40.8-0.81.30.81.21.40.8-0.81.3
Time to tail flick, vehicle, after self-admin2.22.44.4-1.52.1-1.71.4-1.71.3-1.31.91.31.81.90.7-0.71.2
Time to tail flick, test, before self-admin0.80.82.00.1-0.20.50.50.9-0.91.1-0.9-1.1-0.8-0.9-1.41.4-0.8
Time to tail flick, test, after self-admin0.40.41.8-1.30.8-0.61.1-0.30.5-0.50.20.50.30.1-0.60.60.2
Delta time to tail flick, vehicle, before/after SA1.01.01.5-1.21.2-1.20.8-0.91.1-1.11.21.11.21.20.5-0.50.3
Delta time to tail flick, test, before/after SA0.10.10.3-0.40.10.10.50.3-0.20.0-0.3-0.0-0.3-0.3-0.50.6-0.2
Tibia length0.72.14.9-2.22.1-1.81.6-1.61.1-1.01.71.11.41.5-0.10.11.0
Ambulatory time before self-admin0.10.10.20.20.40.10.20.10.10.40.0-0.30.20.4-0.30.30.2
Ambulatory time after self-admin0.20.21.0-1.00.5-0.50.6-0.20.5-0.60.40.60.30.4-0.20.20.2
Bone: tissue strength1.11.12.5-1.51.6-1.41.4-0.91.2-0.71.11.00.80.9-0.30.30.1
Total heroin consumption0.10.20.60.2-0.1-0.0-0.6-0.30.3-0.30.20.20.40.30.8-0.80.0
Bone: trabecular number0.71.22.0-1.11.3-1.30.7-1.31.3-1.41.20.91.11.10.7-0.70.3
Bone: trabecular spacing1.41.82.71.0-1.41.6-0.51.6-1.61.5-1.6-1.3-1.6-1.5-1.11.1-0.6
Bone: trabecular thickness2.73.25.1-1.11.6-2.00.9-2.22.2-1.91.91.62.02.01.8-1.81.4
Bone: trabecular tissue density2.73.75.42.0-1.92.1-1.02.2-1.91.9-2.3-2.1-2.3-2.3-1.31.2-1.9
Water consumed over 24 hours0.10.10.20.3-0.40.3-0.30.3-0.10.3-0.3-0.3-0.3-0.30.1-0.1-0.4
Number of responses in last shaping day0.20.20.5-0.60.30.10.50.2-0.40.2-0.5-0.1-0.7-0.6-0.70.7-0.7